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Melanopsin (Opn4) requirement for normal light-induced circadian phase shifting

Academic Article
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Overview

authors

  • Panda, Satchidananda
  • Sato, T. K.
  • Castrucci, A. M.
  • Rollag, M. D.
  • DeGrip, W. J.
  • Hogenesch, J. B.
  • Provencio, I.
  • Kay, Steve A.

publication date

  • December 2002

journal

  • Science  Journal

abstract

  • The master circadian oscillator in the hypothalamic suprachiasmatic nucleus is entrained to the day/night cycle by retinal photoreceptors. Melanopsin (Opn4), an opsin-based photopigment, is a primary candidate for photoreceptor-mediated entrainment. To investigate the functional role of melanopsin in light resetting of the oscillator, we generated melanopsin-null mice (Opn4-/-). These mice entrain to a light/dark cycle and do not exhibit any overt defect in circadian activity rhythms under constant darkness. However, they display severely attenuated phase resetting in response to brief pulses of monochromatic light, highlighting the critical role of melanopsin in circadian photoentrainment in mammals.

subject areas

  • Animals
  • Biological Clocks
  • Circadian Rhythm
  • Darkness
  • Female
  • Gene Targeting
  • Light
  • Light Signal Transduction
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Motor Activity
  • Retinal Ganglion Cells
  • Rod Opsins
  • Suprachiasmatic Nucleus
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Identity

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.1076848

PubMed ID

  • 12481141
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Additional Document Info

start page

  • 2213

end page

  • 2216

volume

  • 298

issue

  • 5601

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