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Lycopodium clavatum exine microcapsules enable safe oral delivery of 3,4-diaminopyridine for treatment of botulinum neurotoxin A intoxication

Academic Article
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Overview

authors

  • Harris, T. L.
  • Wenthur, C. J.
  • Diego-Taboada, A.
  • Mackenzie, G.
  • Corbitt, T. S.
  • Janda, Kim

publication date

  • 2016

journal

  • Chemical Communications  Journal

abstract

  • 3,4-Diaminopyridine has shown promise in reversing botulinum intoxication, but poor pharmacokinetics and a narrow therapeutic window limit its clinical utility. Thus, we developed a pH-dependent oral delivery platform using club moss spore exines. These exine microcapsules slowed 3,4-diaminopyridine absorption, limited its seizure activity, and enabled delivery of doses which prolonged mouse survival after botulism neurotoxin A intoxication.

subject areas

  • 4-Aminopyridine
  • Administration, Oral
  • Botulinum Toxins, Type A
  • Capsules
  • Lycopodium
  • Microscopy, Electron, Scanning
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Identity

International Standard Serial Number (ISSN)

  • 1359-7345

Digital Object Identifier (DOI)

  • 10.1039/c6cc00615a

PubMed ID

  • 26906286
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Additional Document Info

start page

  • 4187

end page

  • 4190

volume

  • 52

issue

  • 22

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