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Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the central ring system

Academic Article
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Overview

authors

  • Hughes, Robert Owen
  • Walker, J. K.
  • Cubbage, J. W.
  • Fobian, Y. M.
  • Rogier, D. J.
  • Heasley, S. E.
  • Blevis-Bal, R. M.
  • Benson, A. G.
  • Owen, D. R.
  • Jacobsen, E. J.
  • Freskos, J. N.
  • Molyneaux, J. M.
  • Brown, D. L.
  • Stallings, W. C.
  • Acker, B. A.
  • Maddux, T. M.
  • Tollefson, M. B.
  • Williams, J. M.
  • Moon, J. B.
  • Mischke, B. V.
  • Rumsey, J. M.
  • Zheng, Y.
  • MacInnes, A.
  • Bond, B. R.
  • Yu, Y.

publication date

  • August 2009

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

subject areas

  • Administration, Oral
  • Aminopyridines
  • Animals
  • Chemistry, Pharmaceutical
  • Cyclic GMP
  • Cyclic Nucleotide Phosphodiesterases, Type 5
  • Drug Design
  • Humans
  • Hydrogen-Ion Concentration
  • Hypertension
  • Microsomes
  • Models, Chemical
  • Phosphodiesterase 5 Inhibitors
  • Phosphodiesterase Inhibitors
  • Pyrazines
  • Rats
  • Rats, Sprague-Dawley
  • Solubility
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Research

keywords

  • Aminopyrazinone
  • Lead optimization
  • PDE5
  • Pi-pi interaction
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2009.06.004

PubMed ID

  • 19539468
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Additional Document Info

start page

  • 4092

end page

  • 4096

volume

  • 19

issue

  • 15

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