Translation silenced by fused pair of tRNA synthetases

Academic Article

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Overview

authors

• Schimmel, Paul
• Ewalt, K.

publication date

• 2004

journal

• Cell  Journal

abstract

• In this issue of Cell, discover gene-specific translational silencing as a novel function of the fused glutamyl- and prolyl-tRNA synthetase (GluProRS). GluProRS is released from a multisynthetase translation complex in response to gamma-interferon and forms a four-protein GAIT complex that silences translation of ceruloplasmin (Cp), a protein linked to the inflammatory response.

subject areas

• Amino Acyl-tRNA Synthetases
• Ceruloplasmin
• Gene Expression Regulation
• Gene Silencing
• Interferon-gamma
• Protein Biosynthesis

Identity

International Standard Serial Number (ISSN)

• 0092-8674

Digital Object Identifier (DOI)

• 10.1016/j.cell.2004.10.001

PubMed ID

• 15479630

Additional Document Info

start page

• 147

end page

• 148

volume

• 119

issue

• 2