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Translation silenced by fused pair of tRNA synthetases

Academic Article
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Overview

authors

  • Schimmel, Paul
  • Ewalt, K.

publication date

  • October 2004

journal

  • Cell  Journal

abstract

  • In this issue of Cell, discover gene-specific translational silencing as a novel function of the fused glutamyl- and prolyl-tRNA synthetase (GluProRS). GluProRS is released from a multisynthetase translation complex in response to gamma-interferon and forms a four-protein GAIT complex that silences translation of ceruloplasmin (Cp), a protein linked to the inflammatory response.

subject areas

  • Amino Acyl-tRNA Synthetases
  • Ceruloplasmin
  • Gene Expression Regulation
  • Gene Silencing
  • Interferon-gamma
  • Protein Biosynthesis
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Identity

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/j.cell.2004.10.001

PubMed ID

  • 15479630
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Additional Document Info

start page

  • 147

end page

  • 148

volume

  • 119

issue

  • 2

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