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A screening-based approach to circumvent tumor microenvironment-driven intrinsic resistance to BCR-ABL+ inhibitors in Ph+ acute lymphoblastic leukemia

Academic Article
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Overview

authors

  • Singh, H.
  • Shelat, A. A.
  • Singh, A.
  • Boulos, N.
  • Williams, R. T.
  • Guy, Rodney Kiplin

publication date

  • January 2014

journal

  • Journal of Biomolecular Screening  Journal

subject areas

  • Animals
  • Antineoplastic Agents
  • Cytokines
  • Drug Discovery
  • Drug Resistance, Neoplasm
  • Drug Screening Assays, Antitumor
  • Fusion Proteins, bcr-abl
  • High-Throughput Screening Assays
  • Humans
  • Mice
  • Neoplastic Stem Cells
  • Phenotype
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Protein Kinase Inhibitors
  • Tumor Microenvironment
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Research

keywords

  • cancer and cancer drugs
  • cell-based assays
  • kinases
  • phenotypic drug discovery
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Identity

PubMed Central ID

  • PMC3963394

International Standard Serial Number (ISSN)

  • 1087-0571

Digital Object Identifier (DOI)

  • 10.1177/1087057113501081

PubMed ID

  • 23989453
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Additional Document Info

start page

  • 158

end page

  • 167

volume

  • 19

issue

  • 1

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