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GDC-0449-A potent inhibitor of the hedgehog pathway

Academic Article
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Overview

authors

  • Robarge, K. D.
  • Brunton, S. A.
  • Castanedo, G. M.
  • Cui, Y.
  • Dina, M. S.
  • Goldsmith, R.
  • Gould, S. E.
  • Guichert, O.
  • Gunzner, Janet Lorraine
  • Halladay, J.
  • Jia, W.
  • Khojasteh, C.
  • Koehler, M. F. T.
  • Kotkow, K.
  • La, H.
  • LaLonde, R. L.
  • Lau, K.
  • Lee, L.
  • Marshall, D.
  • Marsters, J. C.
  • Murray, L. J.
  • Qian, C.
  • Rubin, L. L.
  • Salphati, L.
  • Stanley, M. S.
  • Stibbard, J. H. A.
  • Sutherlin, D. P.
  • Ubhayaker, S.
  • Wang, S.
  • Wong, S.
  • Xie, M.

publication date

  • 2009

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

subject areas

  • Amides
  • Anilides
  • Animals
  • Benzimidazoles
  • Carcinoma, Basal Cell
  • Cell Line
  • Cerebellar Neoplasms
  • Hedgehog Proteins
  • Humans
  • Medulloblastoma
  • Mice
  • Mice, Nude
  • Pyridines
  • Signal Transduction
  • Structure-Activity Relationship
  • Xenograft Model Antitumor Assays
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Research

keywords

  • GDC-0449
  • Hedgehog pathway
  • Small molecule inhibitor
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2009.08.049

PubMed ID

  • 19716296
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Additional Document Info

start page

  • 5576

end page

  • 5581

volume

  • 19

issue

  • 19

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