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Practical asymmetric synthesis of a potent PDE4 inhibitor via stereoselective enolate alkylation of a chiral aryl-heteroaryl secondary tosylate

Academic Article
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Overview

authors

  • O'Shea, P. D.
  • Chen, C. Y.
  • Chen, W.
  • Dagneau, Philippe
  • Frey, L. F.
  • Grabowski, E. J. J.
  • Marcantonio, K. M.
  • Reamer, R. A.
  • Tan, L.
  • Tillyer, R. D.
  • Roy, A.
  • Wang, X.
  • Zhao, D.

publication date

  • April 2005

journal

  • Journal of Organic Chemistry  Journal

subject areas

  • 3',5'-Cyclic-AMP Phosphodiesterases
  • Combinatorial Chemistry Techniques
  • Cyclic N-Oxides
  • Cyclic Nucleotide Phosphodiesterases, Type 4
  • Enzyme Inhibitors
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Pyridines
  • Stereoisomerism
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Identity

International Standard Serial Number (ISSN)

  • 0022-3263

Digital Object Identifier (DOI)

  • 10.1021/jo048156v

PubMed ID

  • 15822960
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Additional Document Info

start page

  • 3021

end page

  • 3030

volume

  • 70

issue

  • 8

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