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The de-guanidinylated derivative of peramivir remains a potent inhibitor of influenza neuraminidase

Academic Article
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  • Overview
  • Research
  • Identity
  • Additional Document Info
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Overview

authors

  • Bromba, C. M.
  • Mason, Jeremy William
  • Brant, M. G.
  • Chan, T.
  • Lunke, M. D.
  • Petric, M.
  • Boulanger, M. J.
  • Wulff, J. E.

publication date

  • December 2011

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

subject areas

  • Antiviral Agents
  • Crystallography, X-Ray
  • Cyclopentanes
  • Dose-Response Relationship, Drug
  • Drug Design
  • Enzyme Inhibitors
  • Guanidines
  • Humans
  • Influenza A virus
  • Inhibitory Concentration 50
  • Models, Molecular
  • Molecular Structure
  • Neuraminidase
  • Protein Binding
  • Recombinant Proteins
  • Zanamivir
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Research

keywords

  • Guanidine
  • Influenza
  • Inhibitor
  • Neuraminidase
  • Oral availability
  • Peramivir
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2011.09.076

PubMed ID

  • 22001088
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Additional Document Info

start page

  • 7137

end page

  • 7141

volume

  • 21

issue

  • 23

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