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Discovery of selective, orally bioavailable, N-linked arylsulfonamide Na(v)1.7 inhibitors with pain efficacy in mice

Academic Article
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Overview

authors

  • Roecker, Anthony
  • Egbertson, M.
  • Jones, K. L. G.
  • Gomez, R.
  • Kraus, R. L.
  • Li, Y.
  • Koser, A. J.
  • Urban, M. O.
  • Klein, R.
  • Clements, M.
  • Panigel, J.
  • Daley, C.
  • Wang, J.
  • Finger, E. N.
  • Majercak, J.
  • Santarelli, V.
  • Gregan, I.
  • Cato, M.
  • Filzen, T.
  • Jovanovska, A.
  • Wang, Y. H.
  • Wang, D.
  • Joyce, L. A.
  • Sherer, E. C.
  • Peng, X.
  • Wang, X.
  • Sun, H.
  • Coleman, P. J.
  • Houghton, A. K.
  • Layton, M. E.

publication date

  • May 2017

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

subject areas

  • Administration, Oral
  • Animals
  • Disease Models, Animal
  • Drug Evaluation, Preclinical
  • Half-Life
  • Inhibitory Concentration 50
  • Mice
  • NAV1.7 Voltage-Gated Sodium Channel
  • Nitrogen
  • Pain
  • Protein Isoforms
  • Rats
  • Structure-Activity Relationship
  • Sulfonamides
  • Voltage-Gated Sodium Channel Blockers
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Research

keywords

  • Arylsulfonamide
  • Ion channel
  • Na(v)1.7
  • Pain
  • Selectivity
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmc1.2017.03.085

PubMed ID

  • 28389149
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Additional Document Info

start page

  • 2087

end page

  • 2093

volume

  • 27

issue

  • 10

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