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The plasminogen receptor, Plg-R(KT), and macrophage function

Academic Article
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Overview

authors

  • Miles, Lindsey
  • Lighvani, S.
  • Baik, N.
  • Andronicos, N. M.
  • Chen, E. I.
  • Parmer, C. M.
  • Khaldoyanidi, S.
  • Diggs, J. E.
  • Kiosses, W. B.
  • Kamps, M. P.
  • Yates III, John
  • Parmer, R. J.

publication date

  • 2012

journal

  • Journal of Biomedicine & Biotechnology  Journal

abstract

  • When plasminogen binds to cells its activation to plasmin is markedly enhanced compared to the reaction in solution. Thus, cells become armed with the broad spectrum proteolytic activity of plasmin. Cell-surface plasmin plays a key role in macrophage recruitment during the inflammatory response. Proteins exposing basic residues on the cell surface promote plasminogen activation on eukaryotic cells. We have used a proteomics approach combining targeted proteolysis with carboxypeptidase B and multidimensional protein identification technology, MudPIT, and a monocyte progenitor cell line to identify a novel transmembrane protein, the plasminogen receptor, Plg-R(KT). Plg-R(KT) exposes a C-terminal lysine on the cell surface in an orientation to bind plasminogen and promote plasminogen activation. Here we review the characteristics of this new protein, with regard to membrane topology, conservation of sequence across species, the role of its C-terminus in plasminogen binding, its function in plasminogen activation, cell migration, and its role in macrophage recruitment in the inflammatory response.

subject areas

  • Amino Acid Sequence
  • Animals
  • Conserved Sequence
  • Humans
  • Inflammation
  • Lysine
  • Macrophages
  • Molecular Sequence Data
  • Plasminogen
  • Receptors, Urokinase Plasminogen Activator
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Identity

PubMed Central ID

  • PMC3484331

International Standard Serial Number (ISSN)

  • 1110-7251 (Electronic) 1110-7243 (Linking)

Digital Object Identifier (DOI)

  • 10.1155/2012/250464

PubMed ID

  • 23125524
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Additional Document Info

start page

  • 250464

volume

  • 2012

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