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Mechanism of interaction of novel uncharged, centrally active reactivators with OP-hAChE conjugates

Academic Article
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  • Research
  • Identity
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Overview

authors

  • Radic, Z.
  • Sit, R. K.
  • Garcia, E.
  • Zhang, L.
  • Berend, S.
  • Kovarik, Z.
  • Amitai, G.
  • Fokin, Valery
  • Sharpless, K. Barry
  • Taylor, P.

publication date

  • March 2013

journal

  • Chemico-Biological Interactions  Journal

subject areas

  • Acetamides
  • Acetylcholinesterase
  • Cholinesterase Inhibitors
  • Cholinesterase Reactivators
  • Drug Evaluation, Preclinical
  • GPI-Linked Proteins
  • Humans
  • Kinetics
  • Models, Molecular
  • Organophosphates
  • Organophosphorus Compounds
  • Oximes
  • Paraoxon
  • Sarin
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Research

keywords

  • CNS AChE reactivation
  • Molecular modeling
  • Organophosphate intoxication
  • Oxime reactivation
  • Peripheral site
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Identity

PubMed Central ID

  • PMC3561488

International Standard Serial Number (ISSN)

  • 1872-7786 (Electronic) 0009-2797 (Linking)

Digital Object Identifier (DOI)

  • 10.1016/j.cbi.2012.08.014

PubMed ID

  • 22975155
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Additional Document Info

start page

  • 67

end page

  • 71

volume

  • 203

issue

  • 1

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