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The radiomimetic enediyne, 20'-deschloro-C-1027 induces inter-strand DNA crosslinks in hypoxic cells and overcomes cytotoxic radioresistance

Academic Article
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Overview

authors

  • Beerman, T. A.
  • Gawron, L. S.
  • Shen, Ben
  • Kennedy, D. R.

publication date

  • September 2014

journal

  • DNA Repair  Journal

subject areas

  • Aminoglycosides
  • Antibiotics, Antineoplastic
  • Cell Hypoxia
  • Cross-Linking Reagents
  • DNA Breaks
  • Enediynes
  • HCT116 Cells
  • Humans
  • Radiation Tolerance
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Research

keywords

  • C-1027
  • DNA inter-strand crosslinks
  • DNA strand breaks
  • Hypoxia
  • Radiomimetic drugs
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Identity

PubMed Central ID

  • PMC4126566

International Standard Serial Number (ISSN)

  • 1568-7864

Digital Object Identifier (DOI)

  • 10.1016/j.dnarep.2014.06.001

PubMed ID

  • 24986640
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Additional Document Info

start page

  • 165

end page

  • 170

volume

  • 21

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