Cu(II)-mediated ortho C-H alkynylation of (hetero)arenes with terminal alkynes

Academic Article
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publication date

  • 2014

abstract

  • Cu(II)-promoted ortho alkynylation of arenes and heteroarenes with terminal alkynes has been developed to prepare aryl alkynes. A variety of arenes and terminal alkynes bearing different substituents are compatible with this reaction, thus providing an alternative disconnection to Sonogashira coupling.