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RNA transport and long-term memory storage

Academic Article
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Overview

authors

  • Puthanveettil, Sathyanarayanan

publication date

  • 2013

journal

  • RNA Biology  Journal

abstract

  • Several studies have shown that synthesis of new proteins at the synapse is a prerequisite for the storage of long-term memories. Relatively little is known about the availability of distinct mRNA populations for translation at specific synapses, the process that determines mRNA localization, and the temporal designations of localized mRNA translation during memory storage. Techniques such as synaptosome preparation and microdissection of distal neuronal processes of cultured neurons and dendritic layers in brain slices are general approaches used to identify localized RNAs. Exploration of the association of RNA-binding proteins to the axonal transport machinery has led to the development of a strategy to identify RNAs that are transported from the cell body to synapses by molecular motor kinesin. In this article, RNA localization at the synapse, as well as its mechanisms and significance in understanding long-term memory storage, are discussed.

subject areas

  • Animals
  • Dendrites
  • Kinesin
  • Memory, Long-Term
  • Neurons
  • RNA Transport
  • RNA-Binding Proteins
  • Synapses
  • Transcriptome
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Identity

PubMed Central ID

  • PMC3917979

International Standard Serial Number (ISSN)

  • 1547-6286

Digital Object Identifier (DOI)

  • 10.4161/rna.27391

PubMed ID

  • 24356491
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Additional Document Info

start page

  • 1765

end page

  • 1770

volume

  • 10

issue

  • 12

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