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The rise of regulatory RNA

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Overview

authors

  • Morris, Kevin
  • Mattick, J. S.

publication date

  • June 2014

journal

  • Nature Reviews Genetics  Journal

abstract

  • Discoveries over the past decade portend a paradigm shift in molecular biology. Evidence suggests that RNA is not only functional as a messenger between DNA and protein but also involved in the regulation of genome organization and gene expression, which is increasingly elaborate in complex organisms. Regulatory RNA seems to operate at many levels; in particular, it plays an important part in the epigenetic processes that control differentiation and development. These discoveries suggest a central role for RNA in human evolution and ontogeny. Here, we review the emergence of the previously unsuspected world of regulatory RNA from a historical perspective.

subject areas

  • Animals
  • Epigenesis, Genetic
  • Evolution, Molecular
  • Genome, Human
  • Humans
  • RNA, Untranslated
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Identity

PubMed Central ID

  • PMC4314111

International Standard Serial Number (ISSN)

  • 1471-0056

Digital Object Identifier (DOI)

  • 10.1038/nrg3722

PubMed ID

  • 24776770
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Additional Document Info

start page

  • 423

end page

  • 437

volume

  • 15

issue

  • 6

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