Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Adrenal metastases in lung cancer: clinical implications of a mathematical model

Academic Article
uri icon
  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Bazhenova, L.
  • Newton, P.
  • Mason, J.
  • Bethel, Kelly
  • Nieva, Jorge Javier
  • Kuhn, Peter

publication date

  • April 2014

journal

  • Journal of Thoracic Oncology  Journal

abstract

  • Adrenal gland metastases are common in lung cancer. It is well recognized that aggressive treatment of solitary adrenal metastases leads to improved outcomes but the exact nature of adrenal deposits is not well understood. Controversy exists as to the routing of cancer cells to the adrenal gland with some believing that this transmission is lymphatic, in contrast to the more generally accepted theory of hematogenous spread. Recently published mathematical modeling of cancer progression strongly supports the lymphatic theory. With that in mind, we performed a literature review to look for biological plausibility of simulation results and believe that evidence supports the contention that metastases to the adrenal gland can be routed by means of lymphatic channels. This could explain improved survival for patients in whom solitary adrenal metastases are managed aggressively with surgical or radiation modalities. We are calling for clinical trials prospectively testing this hypothesis.

subject areas

  • Adrenal Gland Neoplasms
  • Humans
  • Lung Neoplasms
  • Models, Theoretical
  • Prognosis
  • Survival Rate
scroll to property group menus

Research

keywords

  • Adrenal metastasis
  • Lymphatogenous spread
  • Non-small-cell lung cancer
scroll to property group menus

Identity

PubMed Central ID

  • PMC3989547

International Standard Serial Number (ISSN)

  • 1556-0864

Digital Object Identifier (DOI)

  • 10.1097/jto.0000000000000133

PubMed ID

  • 24736064
scroll to property group menus

Additional Document Info

start page

  • 442

end page

  • 446

volume

  • 9

issue

  • 4

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support