Ligand-enabled gamma-C-H olefination and carbonylation: construction of beta-quaternary carbon centers

Academic Article
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publication date

  • 2014

abstract

  • Monoselective γ-C-H olefination and carbonylation of aliphatic acids has been accomplished by using a combination of a quinoline-based ligand and a weakly coordinating amide directing group. The reaction provides a new route for constructing richly functionalized all-carbon quaternary carbon centers at the β-position of aliphatic acids.