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Genomic instability in pluripotent stem cells: implications for clinical applications

Academic Article
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Overview

authors

  • Peterson, S. E.
  • Loring, Jeanne

publication date

  • February 2014

journal

  • Journal of Biological Chemistry  Journal

abstract

  • Human pluripotent stem cells (hPSCs) are known to acquire genomic changes as they proliferate and differentiate. Despite concerns that these changes will compromise the safety of hPSC-derived cell therapy, there is currently scant evidence linking the known hPSC genomic abnormalities with malignancy. For the successful use of hPSCs for clinical applications, we will need to learn to distinguish between innocuous genomic aberrations and those that may cause tumors. To minimize any effects of acquired mutations on cell therapy, we strongly recommend that cells destined for transplant be monitored throughout their preparation using a high-resolution method such as SNP genotyping.

subject areas

  • Carcinogenesis
  • Clinical Trials as Topic
  • Genetic Variation
  • Genomic Instability
  • Humans
  • Pluripotent Stem Cells
  • Translational Medical Research
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Research

keywords

  • Cell Differentiation
  • Cell Therapy
  • Embryonic Stem Cell
  • Genomics
  • Induced Pluripotent Stem Cells
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Identity

PubMed Central ID

  • PMC3931019

International Standard Serial Number (ISSN)

  • 0021-9258

Digital Object Identifier (DOI)

  • 10.1074/jbc.R113.516419

PubMed ID

  • 24362040
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Additional Document Info

start page

  • 4578

end page

  • 4584

volume

  • 289

issue

  • 8

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