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Hypoxia-inducible factor (HIF)/vascular endothelial growth factor (VEGF) signaling in the retina

Academic Article
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Overview

authors

  • Kurihara, Toshihide
  • Westenskow, Peter
  • Friedlander, Martin

publication date

  • 2014

journal

  • Advances in Experimental Medicine and Biology  Journal

abstract

  • Over a span of two decades, it has become increasingly clear that vascular endothelial growth factor (VEGF) plays an important role in the pathogenesis of retinal diseases including age-related macular degeneration (AMD) and diabetic retinopathy (DR). Based on these observations, anti-VEGF therapies are being developed and approved for clinical use in the treatment of neovascular eye diseases. Hypoxia-inducible factors (HIFs) are transcriptional factors that are stabilized and activated under hypoxic conditions and induce expression of gene products, including VEGF, that are required for cell survival under hypoxia. Here we discuss recent findings from our lab and others that define roles of the HIF-VEGF axis in the retina.

subject areas

  • Aryl Hydrocarbon Receptor Nuclear Translocator
  • Humans
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • Macular Degeneration
  • Retinal Pigment Epithelium
  • Signal Transduction
  • Vascular Endothelial Growth Factor A
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Research

keywords

  • Age-related macular degeneration
  • Hypoxia-inducible factors
  • Retinal pigment epithelium
  • Vascular endothelial growth factor
  • von Hippel-Lindau tumor suppressor
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Identity

International Standard Serial Number (ISSN)

  • 0065-2598 (Print) 0065-2598 (Linking)

Digital Object Identifier (DOI)

  • 10.1007/978-1-4614-3209-8_35

PubMed ID

  • 24664708
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Additional Document Info

start page

  • 275

end page

  • 281

volume

  • 801

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