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Limited hepatitis B virus replication space in the chronically hepatitis C virus-infected liver

Academic Article
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Overview

authors

  • Wieland, Stefan
  • Asabe, S.
  • Engle, R. E.
  • Purcell, R. H.
  • Chisari, Francis

publication date

  • May 2014

journal

  • Journal of Virology  Journal

abstract

  • We compared the kinetics and magnitude of hepatitis B virus (HBV) infection in hepatitis C virus (HCV)-naive and chronically HCV-infected chimpanzees in whose livers type I interferon-stimulated gene (ISG) expression is strongly induced. HBV infection was delayed and attenuated in the HCV-infected animals, and the number of HBV-infected hepatocytes was drastically reduced. These results suggest that establishment of HBV infection and its replication space is limited by the antiviral effects of type I interferon in the chronically HCV-infected liver.

subject areas

  • Animals
  • Coinfection
  • Disease Models, Animal
  • Hepacivirus
  • Hepatitis B
  • Hepatitis B virus
  • Hepatitis C, Chronic
  • Hepatocytes
  • Interferon Type I
  • Liver
  • Pan troglodytes
  • Virus Replication
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Identity

PubMed Central ID

  • PMC3993806

International Standard Serial Number (ISSN)

  • 0022-538X

Digital Object Identifier (DOI)

  • 10.1128/jvi.03553-13

PubMed ID

  • 24522924
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Additional Document Info

start page

  • 5184

end page

  • 5188

volume

  • 88

issue

  • 9

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