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Treatment responses to tooth whitening in twins

Academic Article
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Overview

authors

  • Corby, P. M. A.
  • Biesbrock, A.
  • Gerlach, R.
  • Corby, A. L.
  • Moreira, A.
  • Schork, Nicholas
  • Bretz, W. A.

publication date

  • February 2014

journal

  • Twin Research and Human Genetics  Journal

abstract

  • The aim of this study was to determine heritability estimates of treatment responses to a 10% hydrogen peroxide strip-based whitening system in twins. Eighty-five twin pairs were randomly assigned to 10% hydrogen peroxide whitening strips or placebo strips without peroxide. Both twins (monozygotic or dizygotic) received the same treatment. Maxillary teeth were treated for 30 minutes twice daily for 7 days. Efficacy was measured objectively as L* (light-dark), a* (red-green), and b* (yellow-blue) color change from digital images at baseline (?) and day 8. Heritability estimates for tooth whitening treatment responses for changes from day 8 to baseline were obtained using variance-component methodologies. Whitening treatment responses were highly heritable (h(2) = 71.0) for ?b* and ?a*(p < .0001), but not for ?L* (h(2) = 27.0), which was essentially modulated by environmental factors. This study has demonstrated that both genetic and environmental factors significantly contributed to seven-day whitening treatment responses achieved with 10% hydrogen peroxide strips.
  • The aim of this study was to determine heritability estimates of treatment responses to a 10% hydrogen peroxide strip-based whitening system in twins. Eighty-five twin pairs were randomly assigned to 10% hydrogen peroxide whitening strips or placebo strips without peroxide. Both twins (monozygotic or dizygotic) received the same treatment. Maxillary teeth were treated for 30 minutes twice daily for 7 days. Efficacy was measured objectively as L* (light-dark), a* (red-green), and b* (yellow-blue) color change from digital images at baseline (∆) and day 8. Heritability estimates for tooth whitening treatment responses for changes from day 8 to baseline were obtained using variance-component methodologies. Whitening treatment responses were highly heritable (h(2) = 71.0) for ∆b* and ∆a*(p < .0001), but not for ∆L* (h(2) = 27.0), which was essentially modulated by environmental factors. This study has demonstrated that both genetic and environmental factors significantly contributed to seven-day whitening treatment responses achieved with 10% hydrogen peroxide strips.

subject areas

  • Adolescent
  • Adult
  • Child
  • Humans
  • Hydrogen Peroxide
  • Tooth Bleaching
  • Twins, Dizygotic
  • Twins, Monozygotic
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Research

keywords

  • heritability
  • tooth whitening
  • treatment responses
  • twins
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Identity

International Standard Serial Number (ISSN)

  • 1832-4274

Digital Object Identifier (DOI)

  • 10.1017/thg.2013.87

PubMed ID

  • 24429255
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Additional Document Info

start page

  • 23

end page

  • 26

volume

  • 17

issue

  • 1

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