Regulation of cell adhesion by PAI-1

Academic Article

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Overview

authors

• Loskutoff, David J.
• Curriden, S. A.
• Hu, G.
• Deng, G.

publication date

• January 1999

journal

• APMIS  Journal

abstract

• Type I plasminogen activator inhibitor (PAI-1) is the primary inhibitor of tissue- and urokinase-type plasminogen activators. It circulates in plasma complexed with vitronectin (VN), the primary PAI-1 binding protein. The somatomedin B (SMB) domain of VN contains both the high affinity PAI-1 binding site and the specific site for urokinase plasminogen activator receptor (uPAR). PAI-1 is able to regulate uPAR-mediated cell adhesion by competing with uPAR for VN binding. Binding of PAI-1 to SMD may also affect integrin-mediated cell adhesion to VN by hindering integrin binding to the RGD sequence adjacent to the uPAR binding site.

subject areas

• Animals
• Binding Sites
• Cell Adhesion
• Humans
• Plasminogen Activator Inhibitor 1
• Receptors, Cell Surface
• Receptors, Urokinase Plasminogen Activator
• Vitronectin

Research

keywords

• Type I plasminogen activator inhibitor (PAI-1)
• cell adhesion
• integrins
• urokinase plasminogen activator receptor (uPAR)
• vitronectin (VN)

Identity

International Standard Serial Number (ISSN)

• 0903-4641

PubMed ID

• 10190280

Additional Document Info

start page

• 54

end page

• 61

volume

• 107

issue

• 1