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Cultured granulosa cells produce two plasminogen activators and an antiactivator, each regulated differently by gonadotropins

Academic Article
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Overview

authors

  • Ny, T.
  • Bjersing, L.
  • Hsueh, A. J. W.
  • Loskutoff, David J.

publication date

  • 1985

journal

  • Endocrinology  Journal

abstract

  • Although treatment of cultured granulosa cells with gonadotropins increases their fibrinolytic activity, the biochemical nature of this effect is unclear. We have used sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and fibrin autography techniques to characterize the fibrinolytic components secreted by granulosa cells. The fibrinolytic activity of these cells results from the production of both a tissue-type plasminogen activator (t-PA) and a urokinase-like activator (u-PA). The cells also produce an inhibitor of fibrinolysis (antiactivator). FSH and LH stimulate t-PA activity and suppress antiactivator activity, while u-PA activity is not affected by the gonadotropins. The differential regulation of these molecules by the gonadotropins may be essential for ovulation.

subject areas

  • Animals
  • Cells, Cultured
  • Dexamethasone
  • Estradiol
  • Female
  • Fibrinolysis
  • Gonadotropins
  • Granulosa Cells
  • Molecular Weight
  • Plasminogen Activators
  • Plasminogen Inactivators
  • Promegestone
  • Rats
  • Rats, Inbred Strains
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Identity

International Standard Serial Number (ISSN)

  • 0013-7227

PubMed ID

  • 3918858
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Additional Document Info

start page

  • 1666

end page

  • 1668

volume

  • 116

issue

  • 4

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