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Immunology: Toll-like receptors and antibody responses

Academic Article
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Overview

authors

  • Nemazee, David
  • Gavin, Amanda
  • Hoebe, K.
  • Beutler, Bruce

publication date

  • 2006

journal

  • Nature  Journal

abstract

  • Microbial components, such as lipopolysaccharides, augment immune responses by activating Toll-like receptors (TLRs). Some have interpreted this to mean that TLR signalling might not only help to initiate the adaptive immune response, but may also be required for it. The expanded view is shared by Pasare and Medzhitov, who conclude from an analysis of mice deficient in MyD88 (a TLR-signalling adaptor protein) that the generation of T-dependent antigen-specific antibody responses requires activation of TLRs in B cells. However, we show here that robust antibody responses can be elicited even in the absence of TLR signals. This appreciable TLR-independence of immune responses should be taken into account in the rational design of immunogenic and toleragenic vaccines.

subject areas

  • Adaptor Proteins, Signal Transducing
  • Animals
  • Antibodies
  • Antibody Formation
  • B-Lymphocytes
  • Humans
  • Immunity, Innate
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Models, Immunological
  • Myeloid Differentiation Factor 88
  • Reproducibility of Results
  • Signal Transduction
  • T-Lymphocytes
  • Toll-Like Receptors
  • Vaccines
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Identity

PubMed Central ID

  • PMC3787862

International Standard Serial Number (ISSN)

  • 0028-0836

Digital Object Identifier (DOI)

  • 10.1038/nature04875

PubMed ID

  • 16710369
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Additional Document Info

start page

  • E4

volume

  • 441

issue

  • 7091

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