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Zheng, Qinheng

Graduate Student

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• 13

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  • Zheng, Q., Xu, H. T., Wang, H., Du, W. G. H., Wang, N., Xiong, H., Gu, Y., Noodleman, L., Sharpless, K. B., Yang, G., Wu, P. Sulfur [ 18 F]Fluoride Exchange Click Chemistry Enabled Ultrafast Late-Stage Radiosynthesis Journal of the American Chemical Society  2021 143:3753-3763  DOI:10.1021/jacs.0c09306  PMID:33630577
  • Kitamura, S., Zheng, Q., Woehl, J. L., Solania, A., Chen, E., Dillon, N., Hull, M. V., Kotaniguchi, M., Cappiello, J. R., Kitamura, S., Nizet, V., Sharpless, K. B., et al. Sulfur(VI) Fluoride Exchange (SuFEx)-Enabled High-Throughput Medicinal Chemistry Journal of the American Chemical Society  2020 142:10899-10904  DOI:10.1021/jacs.9b13652  PMID:32479075
  • Zheng, Q., Woehl, J. L., Kitamura, S., Santos-Martins, D., Smedley, C. J., Li, G., Forli, S., Moses, J. E., Wolan, D. W., Sharpless, K. B. SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase Proceedings of the National Academy of Sciences of the United States of America  2019  DOI:10.1073/pnas.1909972116  PMID:31484779
  • Barrow, A. S., Smedley, C. J., Zheng, Q., Li, S., Dong, J., Moses, J. E. The growing applications of SuFEx click chemistry Chemical Society Reviews  2019 48:4731-4758  DOI:10.1039/c8cs00960k  PMID:31364998
  • Smedley, C. J., Zheng, Q., Gao, B., Li, S., Molino, A., Duivenvoorden, H. M., Parker, B. S., Wilson, D. J. D., Sharpless, K. B., Moses, J. E. Bifluoride ion mediated SuFEx trifluoromethylation of sulfonyl fluorides and iminosulfur oxydifluorides Angewandte Chemie-International Edition  2019 58:4552-4556  DOI:10.1002/anie.201813761  PMID:30740848
  • Gahtory, D., Sen, R., Pujari, S., Li, S., Zheng, Q., Moses, J. E., Sharpless, K. B., Zuilhof, H. Quantitative and orthogonal formation and reactivity of SuFEx platforms Chemistry-a European Journal  2018 24:10550-10556  DOI:10.1002/chem.201802356  PMID:29949211
  • Gao, B., Zhang, L., Zheng, Q., Zhou, F., Klivansky, L. M., Lu, J., Liu, Y., Dong, J., Wu, P., Sharpless, K. B. Bifluoride-catalysed sulfur(VI) fluoride exchange reaction for the synthesis of polysulfates and polysulfonates Nature Chemistry  2017 9:1083-1088  DOI:10.1038/nchem.2796  PMID:29064495
  • Wang, H., Zhou, F., Ren, G., Zheng, Q., Chen, H., Gao, B., Klivansky, L., Liu, Y., Wu, B., Xu, Q., Lu, J., Sharpless, K. B., et al. SuFEx-based polysulfonate formation from ethenesulfonyl fluoride-amine adducts Angewandte Chemie-International Edition  2017 56:11203-11208  DOI:10.1002/anie.201701160  PMID:28792119
  • Zha, G. F., Zheng, Q., Leng, J., Wu, P., Qin, H. L., Sharpless, K. B. Palladium-catalyzed fluorosulfonylvinylation of organic iodides Angewandte Chemie-International Edition  2017 56:4849-4852  DOI:10.1002/anie.201701162  PMID:28370917
  • Ren, G., Zheng, Q., Wang, H. Aryl fluorosulfate trapped staudinger reduction Organic Letters  2017 19:1582-1585  DOI:10.1021/acs.orglett.7b00406  PMID:28332844
  • Zheng, Q., Dong, J., Sharpless, K. B. Ethenesulfonyl fluoride (ESF): an on-water procedure for the kilogram-scale preparation Journal of Organic Chemistry  2016 81:11360-11362  DOI:10.1021/acsjoc.6b01423  PMID:27764941
  • Qin, H. L., Zheng, Q., Bare, G. A. L., Wu, P., Sharpless, K. B. A Heck-Matsuda process for the synthesis of β-arylethenesulfonyl fluorides: selectively addressable bis-electrophiles for SuFEx click chemistry Angewandte Chemie-International Edition  2016 55:14155-14158  DOI:10.1002/anie.201608807  PMID:27723200  PMCID:PMC5102157
  • Jiang, G. J., Zheng, Q., Dou, M., Zhuo, L. G., Meng, W., Yu, Z. X. Mild-condition synthesis of allenes from alkynes and aldehydes mediated by tetrahydroisoquinoline (THIQ) Journal of Organic Chemistry  2013 78:11783-11793  DOI:10.1021/jo4018183  PMID:24266693
  • Zheng, Q., Meng, W., Jiang, G. J., Yu, Z. X. CuI-catalyzed C1-alkynylation of tetrahydroisoquinolines (THIQs) by A3 reaction with tunable iminium ions Organic Letters  2013 15:5928-5931  DOI:10.1021/ol402517e  PMID:24237286

Background

education and training

• Ph.D. in Chemistry, Scripps Research 2014 -
• B.Sc. in Chemistry, Peking University 2010 - 2014

advisee of

• graduate advising relationship

  • Sharpless, K. Barry, Ph.D.  candidacy, 2015 -

Contact

full name

• Qinheng Zheng

geographic location

• Scripps California 

Identity

ORCID iD

• http://orcid.org/0000-0002-8440-8673