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Zhang, Yan Jessie
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Zhang, Yan Jessie

Graduate Student
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Positions

  • 2008 - Faculty Member, The University of Texas at Austin
  • 2004 - 2008 Postdoctoral Research Associate, Salk Institute for Biological Studies

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Publications

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    • Fischer, E. C., Hashimoto, K., Zhang, Y., Feldman, A. W., Dien, V. T., Karadeema, R. J., Adhikary, R., Ledbetter, M. P., Krishnamurthy, R., Romesberg, F. E. New codons for efficient production of unnatural proteins in a semisynthetic organism Nature Chemical Biology  2020 16:570-576  DOI:10.1038/s41589-020-0507-z  PMID:32251411
    • Loe, T. K., Li, J. S. Z., Zhang, Y., Azeroglu, B., Boddy, M. N., Denchi, E. L. Telomere length heterogeneity in ALT cells is maintained by PML-dependent localization of the BTR complex to telomeres Genes & Development  2020 34:650-662  DOI:10.1101/gad.333963.119  PMID:32217664  PMCID:PMC7197349
    • Burkholder, N. T., Sipe, S. N., Escobar, E. E., Venkatramani, M., Irani, S., Yang, W., Wu, H., Matthews, W. M., Brodbelt, J. S., Zhang, Y. Mapping RNAPII CTD phosphorylation reveals that the identity and modification of seventh heptad residues direct Tyr1 phosphorylation ACS Chemical Biology  2019 14:2264-2275  DOI:10.1021/acschembio.9b00610  PMID:31553563
    • Mayfield, J. E., Irani, S., Escobar, E. E., Zhang, Z., Burkholder, N. T., Robinson, M. R., Mehaffey, M. R., Sipe, S. N., Yang, W., Prescott, N. A., Kathuria, K. R., Liu, Z., et al. Tyr1 phosphorylation promotes phosphorylation of Ser2 on the C-terminal domain of eukaryotic RNA polymerase II by P-TEFb Elife  2019 8  DOI:10.7554/eLife.48725  PMID:31385803  PMCID:PMC6715403
    • Baas, B. J., Medellin, B. P., LeVieux, J. A., de Ruijter, M., Zhang, Y. J., Brown, S. D., Akiva, E., Babbitt, P. C., Whitman, C. P. Structural, kinetic, and mechanistic analysis of an asymmetric 4-oxalocrotonate tautomerase trimer Biochemistry  2019 58:2617-2627  DOI:10.1021/acs.biochem.9b00303  PMID:31074977
    • Irani, S., Sipe, S. N., Yang, W., Burkholder, N. T., Lin, B., Sim, K., Matthews, W. L., Brodbelt, J. S., Zhang, Y. Structural determinants for accurate dephosphorylation of RNA polymerase II by its cognate C-terminal domain (CTD) phosphatase during eukaryotic transcription Journal of Biological Chemistry  2019 294:8592-8605  DOI:10.1074/jbc.RA119.007697  PMID:30971428  PMCID:PMC6544836
    • Wang, S. A., Ko, Y., Zeng, J., Geng, Y., Ren, D. A., Ogasawara, Y., Irani, S., Zhang, Y., Liu, H. W. Identification of the Formycin A biosynthetic gene cluster from streptomyces kaniharaensis illustrates the interplay between biological pyrazolopyrimidine formation and de novo purine biosynthesis Journal of the American Chemical Society  2019 141:6127-6131  DOI:10.1021/jacs.9b00241  PMID:30942582  PMCID:PMC6612245
    • Burkholder, N. T., Mayfield, J. E., Yu, X., Irani, S., Arce, D. K., Jiang, F., Matthews, W. L., Xue, Y., Zhang, Y. J. Phosphatase activity of small C-terminal domain phosphatase 1 (SCP1) controls the stability of the key neuronal regulator RE1-silencing transcription factor (REST) Journal of Biological Chemistry  2018 293:16851-16861  DOI:10.1074/jbc.RA118.004722  PMID:30217818  PMCID:PMC6204920
    • LeVieux, J. A., Medellin, B., Johnson, W. H., Erwin, K., Li, W., Johnson, I. A., Zhang, Y. J., Whitman, C. P. Structural characterization of the hydratase-aldolases, NahE and PhdJ: implications for the specificity, catalysis, and N-acetylneuraminate lyase subgroup of the aldolase superfamily Biochemistry  2018 57:3524-3536  DOI:10.1021/acs.biochem.8b00532  PMID:29856600
    • Irani, S., Naowarojna, N., Tang, Y., Kathuria, K. R., Wang, S., Dhembi, A., Lee, N., Yan, W., Lyu, H., Costello, C. E., Liu, P., Zhang, Y. J. Snapshots of C-S cleavage in Egt2 reveals substrate specificity and reaction mechanism Cell Chemical Biology  2018 25:519-529  DOI:10.1016/j.chembiol.2018.02.002  PMID:29503207  PMCID:PMC5959753
    • Davidson, R., Baas, B. J., Akiva, E., Holliday, G. L., Polacco, B. J., LeVieux, J. A., Pullara, C. R., Zhang, Y. J., Whitman, C. P., Babbitt, P. C. A global view of structure-function relationships in the tautomerase superfamily Journal of Biological Chemistry  2018 293:2342-2357  DOI:10.1074/jbc.M117.815340  PMID:29184004  PMCID:PMC5818174
    • Stack, T. M. M., Li, W., Johnson, W. H., Zhang, Y. J., Whitman, C. P. Inactivation of 4-oxalocrotonate tautomerase by 5-Halo-2-hydroxy-2,4-pentadienoates Biochemistry  2018 57:1012-1021  DOI:10.1021/acs.biochem.7600899  PMID:29303557
    • Burkholder, N. T., Medellin, B., Irani, S., Matthews, W., Showalter, S. A., Zhang, Y. J. Chemical tools for studying the impact of cis/trans prolyl isomerization on signaling: a case study on RNA polymerase II phosphatase activity and specificity Methods in Enzymology  2018 607:269-297  DOI:10.1016/bs.mie.2018.04.020  PMID:30149861  PMCID:PMC6701646
    • LeVieux, J. A., Baas, B. J., Kaoud, T. S., Davidson, R., Babbitt, P. C., Zhang, Y. J., Whitman, C. P. Kinetic and structural characterization of a cis-3-Chloroacrylic acid dehalogenase homologue in Pseudomonas sp UW4: A potential step between subgroups in the tautomerase superfamily Archives of Biochemistry and Biophysics  2017 636:50-56  DOI:10.1016/j.abb.2017.10.018  PMID:29111295  PMCID:PMC5714680
    • Lee, C. H., Romain, G., Yan, W., Watanabe, M., Charab, W., Todorova, B., Lee, J., Triplett, K., Donkor, M., Lungu, O. I., Lux, A., Marshall, N., et al. IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector functions Nature Immunology  2017 18:889-+  DOI:10.1038/ni.3770  PMID:28604720  PMCID:PMC6015732
    • Gibbs, E. B., Lu, F., Portz, B., Fisher, M. J., Medellin, B. P., Laremore, T. N., Zhang, Y. J., Gilmour, D. S., Showalter, S. A. Phosphorylation induces sequence-specific conformational switches in the RNA polymerase II C-terminal domain Nature Communications  2017 8  DOI:10.1038/ncomms15233  PMID:28497798  PMCID:PMC5437310
    • Portz, B., Lu, F., Gibbs, E. B., Mayfield, J. E., Mehaffey, M. R., Zhang, Y. J., Brodbelt, J. S., Showalter, S. A., Gilmour, D. S. Structural heterogeneity in the intrinsically disordered RNA polymerase II C-terminal domain Nature Communications  2017 8  DOI:10.1038/ncomms15231  PMID:28497792  PMCID:PMC5437306
    • Yan, W., Stone, E., Zhang, Y. J. Structural snapshots of an engineered cystathionine-γ-lyase reveal the critical role of electrostatic interactions in the active site Biochemistry  2017 56:876-885  DOI:10.1021/acs.biochem.6b01172  PMID:28106980  PMCID:PMC5376214
    • Mayfield, J. E., Robinson, M. R., Cotham, V. C., Irani, S., Matthews, W. L., Ram, A., Gilmour, D. S., Cannon, J. R., Zhang, Y. J., Brodbelt, J. S. Mapping the phosphorylation pattern of Drosophila melanogaster RNA polymerase II carboxyl-terminal domain using ultraviolet photodissociation mass spectrometry ACS Chemical Biology  2017 12:153-162  DOI:10.1021/acschembio.6b00729  PMID:28103682  PMCID:PMC5376213
    • Cramer, S. L., Saha, A., Liu, J., Tadi, S., Tiziani, S., Yan, W., Triplett, K., Lamb, C., Alters, S. E., Rowlinson, S., Zhang, Y. J., Keating, M. J., et al. Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth Nature Medicine  2017 23:120-127  DOI:10.1038/nm.4232 https://www.nature.com/articles/nm.4232#supplementary-information  PMID:27869804  PMCID:PMC5218918
    • Mayfield, J. E., Burkholder, N. T., Zhang, Y. J. Dephosphorylating eukaryotic RNA polymerase II Biochimica Et Biophysica Acta-Proteins and Proteomics  2016 1864:372-387  DOI:10.1016/j.bbapap.2016.01.007  PMID:26779935  PMCID:PMC4761483
    • Irani, S., Yogesha, S. D., Mayfield, J., Zhang, M., Zhang, Y., Matthews, W. L., Nie, G., Prescott, N. A., Zhang, Y. J. Structure of Saccharomyces cerevisiae Rtr1 reveals an active site for an atypical phosphatase Science Signaling  2016 9  DOI:10.1126/scisignal.aad4805  PMID:26933063  PMCID:PMC4801511
    • Li, W., Irani, S., Crutchfield, A., Hodge, K., Matthews, W., Patel, P., Zhang, Y. J., Stone, E. Intramolecular cleavage of the hASRGL1 homodimer occurs in two stages Biochemistry  2016 55:960-969  DOI:10.1021/acs.biochem.5b01157  PMID:26780688  PMCID:PMC4809669
    • LeVieux, J. A., Johnson, W. H., Erwin, K., Li, W., Zhang, Y. J., Whitman, C. P. The bacterial catabolism of polycyclic aromatic hydrocarbons: Characterization of three hydratase-aldolase-catalyzed reactions Perspectives in Science  2016 9:33-41  DOI:https://doi.org/10.1016/j.pisc.2016.03.025
    • Bapat, S. P., Myoung Suh, J., Fang, S., Liu, S., Zhang, Y., Cheng, A., Zhou, C., Liang, Y., LeBlanc, M., Liddle, C., Atkins, A. R., Yu, R. T., et al. Depletion of fat-resident T-reg cells prevents age-associated insulin resistance Nature  2015 528:137-141  DOI:10.1038/nature16151  PMID:26580014  PMCID:PMC4670283
    • Yan, W., Song, H., Song, F., Guo, Y., Wu, C. H., Sae Her, A., Pu, Y., Wang, S., Naowarojna, N., Weitz, A., Hendrich, M. P., Costello, C. E., et al. Endoperoxide formation by an α-ketoglutarate-dependent mononuclear non-haem iron enzyme Nature  2015 527:539-543  DOI:10.1038/nature15519  PMID:26524521  PMCID:PMC4804460
    • Mayfield, J. E., Fan, S., Wei, S., Zhang, M., Li, B., Ellington, A. D., Etzkorn, F. A., Zhang, Y. J. Chemical tools to decipher regulation of phosphatases by proline isomerization on eukaryotic RNA polymerase II ACS Chemical Biology  2015 10:2405-2414  DOI:10.1021/acschembio.5b00296  PMID:26332362  PMCID:PMC4788383
    • He, Y., Guo, X., Yu, Z. H., Wu, L., Gunawan, A. M., Zhang, Y., Dixon, J. E., Zhang, Z. Y. A potent and selective inhibitor for the UBLCP1 proteasome phosphatase Bioorganic & Medicinal Chemistry  2015 23:2798-2809  DOI:10.1016/j.bmc.2015.03.066  PMID:25907364  PMCID:PMC4451428
    • Chen, C. H., Li, W., Sultana, R., You, M. H., Kondo, A., Shahpasand, K., Kim, B. M., Luo, M. L., Nechama, M., Lin, Y. M., Yao, Y., Lee, T. H., et al. Pin1 cysteine-113 oxidation inhibits its catalytic activity and cellular function in Alzheimer's disease Neurobiology of Disease  2015 76:13-23  DOI:10.1016/j.nbd.2014.12.027  PMID:25576397  PMCID:PMC4423621
    • O'Brien, J. P., Li, W., Zhang, Y., Brodbelt, J. S. Characterization of native protein complexes using ultraviolet photodissociation mass spectrometry Journal of the American Chemical Society  2014 136:12920-12928  DOI:10.1021/ja505217w  PMID:25148649  PMCID:PMC4351866
    • Yogesha, S. D., Mayfield, J. E., Zhang, Y. Cross-talk of phosphorylation and prolyl isomerization of the C-terminal domain of RNA Polymerase II Molecules  2014 19:1481-1511  DOI:10.3390/molecules19021481  PMID:24473209  PMCID:PMC4350670
    • Zhang, M., Yogesha, S. D., Mayfield, J. E., Gill, G. N., Zhang, Y. Viewing serine/threonine protein phosphatases through the eyes of drug designers FEBS Journal  2013 280:4739-4760  DOI:10.1111/febs.12481  PMID:23937612
    • Luo, Y., Yogesha, S. D., Cannon, J. R., Yan, W., Ellington, A. D., Brodbelt, J. S., Zhang, Y. Novel modifications on C-terminal domain of RNA polymerase II can fine-tune the phosphatase activity of Ssu72 ACS Chemical Biology  2013 8:2042-2052  DOI:10.1021/cb400229c  PMID:23844594
    • Shaw, J. B., Li, W., Holden, D. D., Zhang, Y., Griep-Raming, J., Fellers, R. T., Early, B. P., Thomas, P. M., Kelleher, N. L., Brodbelt, J. S. Complete protein characterization using top-down mass spectrometry and ultraviolet photodissociation Journal of the American Chemical Society  2013 135:12646-12651  DOI:10.1021/ja4029654  PMID:23697802  PMCID:PMC3757099
    • Li, W., Cantor, J. R., Yogesha, S. D., Yang, S., Chantranupong, L., Liu, J. Q., Agnello, G., Georgiou, G., Stone, E. M., Zhang, Y. Uncoupling intramolecular processing and substrate hydrolysis in the N-terminal nucleophile hydrolase hASRGL1 by circular permutation ACS Chemical Biology  2012 7:1840-1847  DOI:10.1021/cb300232n  PMID:22891768  PMCID:PMC3514461
    • Zhang, M., Wang, X. J., Chen, X., Bowman, M. E., Luo, Y., Noel, J. P., Ellington, A. D., Etzkorn, F. A., Zhang, Y. Structural and kinetic analysis of prolyl-isomerization/phosphorylation cross-talk in the CTD code ACS Chemical Biology  2012 7:1462-1470  DOI:10.1021/cb3000887  PMID:22670809  PMCID:PMC3423551
    • Tavares, C. D. J., O'Brien, J. P., Abramczyk, O., Devkota, A. K., Shores, K. S., Ferguson, S. B., Kaoud, T. S., Warthaka, M., Marshall, K. D., Keller, K. M., Zhang, Y., Brodbelt, J. S., et al. Calcium/calmodulin stimulates the autophosphorylation of elongation factor 2 kinase on Thr-348 and Ser-500 to regulate its activity and calcium dependence Biochemistry  2012 51:2232-2245  DOI:10.1021/bi201788e  PMID:22329831  PMCID:PMC3401519
    • Burks, E. A., Yan, W., Johnson Jr., W. H., Li, W., Schroeder, G. K., Min, C., Gerratana, B., Zhang, Y., Whitman, C. P. Kinetic, crystallographic, and mechanistic characterization of TomN: elucidation of a function for a 4-oxalocrotonate tautomerase homologue in the tomaymycin biosynthetic pathway Biochemistry  2011 50:7600-7611  DOI:10.1021/bi200947w  PMID:21809870  PMCID:PMC3164527
    • Zhang, M., Cho, E. J., Burstein, G., Siegel, D., Zhang, Y. Selective inactivation of a human neuronal silencing phosphatase by a small molecule inhibitor ACS Chemical Biology  2011 6:511-519  DOI:10.1021/cb100357t  PMID:21348431
    • Lee, T. H., Chen, C. H., Suizu, F., Huang, P., Schiene-Fischer, C., Daum, S., Zhang, Y. J., Goate, A., Chen, R. H., Zhou, X. Z., Lu, K. P. Death-associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function Molecular Cell  2011 42:147-159  DOI:10.1016/j.molcel.2011.03.005  PMID:21497122  PMCID:PMC3088080
    • Zhang, Y., Zhang, M., Zhang, Y. Crystal structure of Ssu72, an essential eukaryotic phosphatase specific for the C-terminal domain of RNA polymerase II, in complex with a transition state analogue Biochemical Journal  2011 434:435-444  DOI:10.1042/bj20101471  PMID:21204787
    • Xu, G. G., Zhang, Y., Mercedes-Camacho, A. Y., Etzkorn, F. A. A reduced-amide inhibitor of Pin1 binds in a conformation resembling a twisted-amide transition state Biochemistry  2011 50:9545-9550  DOI:10.1021/bi201055c  PMID:21980916  PMCID:PMC3289549
    • Zhang, M., Liu, J., Kim, Y., Dixon, J. E., Pfaff, S. L., Gill, G. N., Noel, J. P., Zhang, Y. Structural and functional analysis of the phosphoryl transfer reaction mediated by the human small C-terminal domain phosphatase, Scp1 Protein Science  2010 19:974-986  DOI:10.1002/pro.375  PMID:20222012  PMCID:PMC2868240
    • Zhang, M., Gill, G. N., Zhang, Y. Bio-molecular architects: a scaffold provided by the C-terminal domain of eukaryotic RNA polymerase II Nano Reviews  2010 1  DOI:10.3402/nano.v1i0.5502  PMID:22110856  PMCID:PMC3215212
    • Zhang, Y., Daum, S., Wildemann, D., Zhou, X. Z., Verdecia, M. A., Bowman, M. E., Lucke, C., Hunter, T., Lu, K. P., Fischer, G., Noel, J. P. Structural basis for high-affinity peptide inhibition of human Pin1 ACS Chemical Biology  2007 2:320-328  DOI:10.1021/cb7000044  PMID:17518432  PMCID:PMC2692202
    • Zhang, Y., Ki, Y., Genoud, N., Gao, J. M., Kelly, J. W., Pfaff, S. L., Gill, G. N., Dixon, J. E., Noel, J. P. Determinants for dephosphorylation of the RNA polymerase II C-terminal domain by Scp1 Molecular Cell  2006 24:759-770  DOI:10.1016/j.molcel.2006.10.027  PMID:17157258  PMCID:PMC2859291
    • Jager, M., Zhang, Y., Bieschke, J., Nguyen, H., Dendle, M., Bowman, M. E., Noel, J. P., Gruebele, M., Kelly, J. W. Structure-function-folding relationship in a WW domain Proceedings of the National Academy of Sciences of the United States of America  2006 103:10648-10653  DOI:10.1073/pnas.0600511103  PMID:16807295  PMCID:PMC1502286
    • degree-related publication Cheng, H., Chong, Y. H., Hwang, I., Tavassoli, A., Zhang, Y., Wilson, I. A., Benkovic, S. J., Boger, D. L. Design, synthesis, and biological evaluation of 10-methanesulfonyl-DDACTHF, 10-methanesulfonyl-5-DACTHF, and 10-methylthio-DDACTHF as potent inhibitors of GAR Tfase and the de novo purine biosynthetic pathway Bioorganic & Medicinal Chemistry  2005 13:3577-3585  DOI:10.1016/j.bmc.2004.12.004  PMID:15848770
    • degree-related publication Cheng, H., Hwang, I., Chong, Y. H., Tavassoli, A., Webb, M. E., Zhang, Y., Wilson, I. A., Benkovic, S. J., Boger, D. L. Synthesis and biological evaluation of N-{4- 5-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(2,2,2-trifluoro acetyl)pentyl)benzoyl}-L-glutamic acid as a potential inhibitor of GAR Tfase and the de novo purine biosynthetic pathway Bioorganic & Medicinal Chemistry  2005 13:3593-3599  DOI:10.1016/j.bme.2004.11.049  PMID:15848772
    • degree-related publication Chong, Y., Hwang, I., Tavassoli, A., Zhang, Y., Wilson, I. A., Benkovic, S. J., Boger, D. L. Synthesis and biological evaluation of α- and γ-carboxamide derivatives of 10-CF3CO-DDACTHF Bioorganic & Medicinal Chemistry  2005 13:3587-3592  DOI:10.1016/j.bme.2004.11.050  PMID:15848771
    • degree-related publication Zhang, Y., Wang, L., Schultz, P. G., Wilson, I. A. Crystal structures of apo wild-type M. jannaschii tyrosyl-tRNA synthetase (TyrRS) and an engineered TyrRS specific for O-methyl-L-tyrosine Protein Science  2005 14:1340-1349  DOI:10.1110/ps.041239305  PMID:15840835  PMCID:PMC2253270
    • degree-related publication Marsilje, T. H., Hedrick, M. P., Desharnais, J., Capps, K., Tavassoli, A., Zhang, Y., Wilson, I. A., Benkovic, S. J., Boger, D. L. 10-(2-benzoxazolcarbonyl)-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid: a potential inhibitor of GAR transformylase and AICAR transformylase Bioorganic & Medicinal Chemistry  2003 11:4503-4509  DOI:10.1016/s0968-0896(03)00457-7  PMID:13129586
    • degree-related publication Desharnais, J., Hwang, I., Zhang, Y., Tavassoli, A., Baboval, J., Benkovic, S. J., Wilson, I. A., Boger, D. L. Design, synthesis and biological evaluation of 10-CF3CO-DDACTHF analogues and derivatives as inhibitors of GAR Tfase and the de novo purine biosynthetic pathway Bioorganic & Medicinal Chemistry  2003 11:4511-4521  DOI:10.1016/s0968-0896(03)00458-9  PMID:13129587
    • degree-related publication Marsilje, T. H., Hedrick, M. P., Desharnais, J., Tavassoli, A., Zhang, Y., Wilson, I. A., Benkovic, S. J., Boger, D. L. Design, synthesis, and biological evaluation of simplified alpha-keto heterocycle, trifluoromethyl ketone, and formyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase Bioorganic & Medicinal Chemistry  2003 11:4487-4501  DOI:10.1016/s0968-0896(03)00456-5  PMID:13129585
    • degree-related publication Zhang, Y., Desharnais, J., Marsilje, T. H., Li, C. L., Hedrick, M. P., Gooljarsingh, L. T., Tavassoli, A., Benkovic, S. J., Olson, A. J., Boger, D. L., Wilson, I. A. Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid Biochemistry  2003 42:6043-6056  DOI:10.1021/bi034219c  PMID:12755606
    • Peters, R. J., Carter, O. A., Zhang, Y., Matthews, B. W., Croteau, R. B. Bifunctional abletadiene synthase: mutual structural dependence of the active sites for protonation-initiated and ionization-initiated cyclizations Biochemistry  2003 42:2700-2707  DOI:10.1021/bi020492n  PMID:12614165
    • degree-related publication Zhang, Y., Desharnais, J., Greasley, S. E., Beardsley, G. P., Boger, D. L., Wilson, I. A. Crystal structures of human GAR Tfase at low and high pH and with substrate β-GAR Biochemistry  2002 41:14206-14215  DOI:10.1021/bi020522m  PMID:12450384
    • degree-related publication Marsilje, T. H., Labroli, M. A., Hedrick, M. P., Jin, Q., Desharnais, J., Baker, S. J., Gooljarsingh, L. T., Ramcharan, J., Tavassoli, A., Zhang, Y., Wilson, I. A., Beardsley, G. P., et al. 10-formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway Bioorganic & Medicinal Chemistry  2002 10:2739-2749  DOI:10.1016/s0968-0896(02)00102-5  PMID:12057663
    • Lowther, W. T., Zhang, Y., Sampson, P. B., Honek, J. F., Matthews, B. W. Insights into the mechanism of Escherichia coli methionine aminopeptidase from the structural analysis of reaction products and phosphorus-based transition-state analogues Biochemistry  1999 38:14810-14819  DOI:10.1021/bi991711g  PMID:10555963
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Background

education and training

  • Ph.D. in Biology, Scripps Research 2001 - 2004
  • M.S. in Chemistry, University of Oregon 1998 - 2000
  • B.S. in Chemistry, Tsinghua University 1993 - 1997

advisee of

  • graduate advising relationship

    • Wilson, Ian, Ph.D.  candidacy, 2002 - 2004
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Contact

full name

  • Yan Jessie Zhang

geographic location

  • Scripps California 
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Identity

ORCID iD

  • ORCID iD http://orcid.org/0000-0002-9360-5388

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