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Yue, Eddy W
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Yue, Eddy W

Graduate Student
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Positions

  • 2004 - Scientist, Incyte Genomics

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  • Doctoral Dissertation
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Publications

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  • academic article

    • Yue, E. W., Sparks, R., Polam, P., Modi, D., Douty, B., Wayland, B., Glass, B., Takvorian, A., Glenn, J., Zhu, W., Bower, M., Liu, X., et al. INCB24360 (epacadostat), a highly potent and selective indoleamine-2,3-dioxygenase 1 (ID01) inhibitor for immunooncology ACS Medicinal Chemistry Letters  2017 8:486-491  DOI:10.1021/acsmedchemlett.6b00391  PMID:28523098  PMCID:PMC5430407
    • Liu, X., Shin, N., Koblish, H. K., Yang, G., Wang, Q., Wang, K., Leffet, L., Hansbury, M. J., Thomas, B., Rupar, M., Waeltz, P., Bowman, K. J., et al. Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity Blood  2010 115:3520-3530  DOI:10.1182/blood-2009-09-246124  PMID:20197554
    • Hu, Z., Jiang, X., Albright, C. F., Graciani, N., Yue, E., Zhang, M., Zhang, S. Y., Bruckner, R., Diamond, M., Dowling, R., Rafalski, M., Yeleswaram, S., et al. Discovery of matrix metalloproteases selective and activated peptide-doxorubicin prodrugs as anti-tumor agents Bioorganic & Medicinal Chemistry Letters  2010 20:853-856  DOI:10.1016/j.bmcl.2009.12.084  PMID:20060717
    • Koblish, H. K., Hansbury, M. J., Bowman, K. J., Yang, G., Neilan, C. L., Haley, P. J., Burn, T. C., Waeltz, P., Sparks, R. B., Yue, E. W., Combs, A. P., Scherle, P. A., et al. Hydroxyamidine inhibitors of indoleamine-2,3-dioxygenase potently suppress systemic tryptophan catabolism and the growth of IDO-expressing tumors Molecular Cancer Therapeutics  2010 9:489-498  DOI:10.1158/1535-7163.mct-09-0628  PMID:20124451
    • Yue, E. W., Douty, B., Wayland, B., Bower, M., Liu, X., Leffet, L., Wang, Q., Bowman, K. J., Hansbury, M. J., Liu, C., Wei, M., Li, Y., et al. Discovery of potent competitive inhibitors of indoleamine 2,3-dioxygenase with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model Journal of Medicinal Chemistry  2009 52:7364-7367  DOI:10.1021/jm900518f  PMID:19507862
    • Hartz, R. A., Ahuja, V. T., Arvanitis, A. G., Rafalski, M., Yue, E. W., Denhart, D. J., Schmitz, W. D., Ditta, J. L., Deskus, J. A., Brenner, A. B., Hobbs, F. W., Payne, J., et al. Synthesis, structure-activity relationships, and in vivo evaluation of N3-phenylpyrazinones as novel corticotropin-releasing factor-1 (CRF1) receptor antagonists Journal of Medicinal Chemistry  2009 52:4173-4191  DOI:10.1021/jm900301y  PMID:19552437
    • Hartz, R. A., Ahuja, V. T., Rafalski, M., Schmitz, W. D., Brenner, A. B., Denhart, D. J., Ditta, J. L., Deskus, J. A., Yue, E. W., Arvanitis, A. G., Lelas, S., Li, Y. W., et al. In vitro intrinsic clearance-based optimization of N3-phenylpyrazinones as corticotropin-releasing factor-1 (CRF1) receptor antagonists Journal of Medicinal Chemistry  2009 52:4161-4172  DOI:10.1021/jm900302q  PMID:19552436
    • Douty, B., Wayland, B., Ala, P. J., Bower, M. J., Pruitt, J., Bostrom, L., Wei, M., Klabe, R., Gonneville, L., Wynn, R., Burn, T. C., Liu, P. C. C., et al. Isothiazolidinone inhibitors of PTP1B containing imidazoles and imidazolines Bioorganic & Medicinal Chemistry Letters  2008 18:66-71  DOI:10.1016/j.bmcl.2007.11.012  PMID:18037290
    • Ala, P. J., Gonneville, L., Hillman, M., Becker-Pasha, M., Yue, E. W., Douty, B., Wayland, B., Polam, P., Crawley, M. L., McLaughlin, E., Sparks, R. B., Glass, B., et al. Structural insights into the design of nonpeptidic isothiazolidinone-containing inhibitors of protein-tyrosine phosphatase 1B Journal of Biological Chemistry  2006 281:38013-38021  DOI:10.1074/jbc.M607913200  PMID:17028182
    • Ala, P. J., Gonneville, L., Hillman, M. C., Becker-Pasha, M., Wei, M., Reid, B. G., Klabe, R., Yue, E. W., Wayland, B., Douty, B., Polam, P., Wasserman, Z., et al. Structural basis for inhibition of protein-tyrosine phosphatase 1B by isothiazolidinone heterocyclic phosphonate mimetics Journal of Biological Chemistry  2006 281:32784-32795  DOI:10.1074/jbc.M606873200  PMID:16916797
    • Yue, E. W., Wayland, B., Douty, B., Crawley, M. L., McLaughlin, E., Takvorian, A., Wasserman, Z., Bower, M. J., Wei, M., Li, Y., Ala, P. J., Gonneville, L., et al. Isothiazolidinone heterocycles as inhibitors of protein tyrosine phosphatases: Synthesis and structure-activity relationships of a peptide scaffold Bioorganic & Medicinal Chemistry  2006 14:5833-5849  DOI:10.1016/j.bmc.2006.05.032  PMID:16769216
    • Combs, A. P., Zhu, W., Crawley, M. L., Glass, B., Polam, P., Sparks, R. B., Modi, D., Takvorian, A., McLaughlin, E., Yue, E. W., Wasserman, Z., Bower, M., et al. Potent benzimidazole sulfonamide protein tyrosine phosphatase 1B inhibitors containing the heterocyclic (S)-isothiazolidinone phosphotyrosine mimetic Journal of Medicinal Chemistry  2006 49:3774-3789  DOI:10.1021/jm0600904  PMID:16789735
    • Combs, A. P., Yue, E. W., Bower, M., Ala, P. J., Wayland, B., Douty, B., Takvorian, A., Polam, P., Wasserman, Z., Zhu, W., Crawley, M. L., Pruitt, J., et al. Structure-based design and discovery of protein tyrosine phosphatase inhibitors incorporating novel isothiazolidinone heterocyclic phosphotyrosine mimetics Journal of Medicinal Chemistry  2005 48:6544-6548  DOI:10.1021/jm.0504555  PMID:16220970
    • Albright, C. F., Graciani, N., Han, W., Yue, E., Stein, R., Lai, Z., Diamond, M., Dowling, R., Grimminger, L., Zhang, S. Y., Behrens, D., Musselman, A., et al. Matrix metalloproteinase-activated doxorubicin prodrugs inhibit HT1080 xenograft growth doxorubicin with less toxicity Molecular Cancer Therapeutics  2005 4:751-760  DOI:10.1158/1535-7163.mct-05-0006  PMID:15897239
    • Yue, E. W., DiMeo, S. V., Higley, C. A., Markwalder, J. A., Burton, C. R., Benfield, P. A., Grafstrom, R. H., Cox, S., Muckelbauer, J. K., Smallwood, A. M., Chen, H., Chang, C. H., et al. Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. Part 4: Heterocycles at C3 Bioorganic & Medicinal Chemistry Letters  2004 14:343-346  DOI:10.1016/j.bmcl.2003.11.008  PMID:14698155
    • Yue, E. W., Higley, C. A., DiMeo, S. V., Carini, D. J., Nugiel, D. A., Benware, C., Benfield, P. A., Burton, C. R., Cox, S., Grafstrom, R. H., Sharp, D. M., Sisk, L. M., et al. Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. 3. Structure activity relationships at C3 Journal of Medicinal Chemistry  2002 45:5233-5248  DOI:10.1021/jm0201722  PMID:12431051
    • degree-related publication Nicolaou, K. C.*, Yue, E. W.* Total synthesis of selected natural products Pure and Applied Chemistry  1997 69:413-418  DOI:10.1351/pac199769030413 (* = equal contribution)
    • degree-related publication Nicolaou, K. C., Postema, M. H. D., Yue, E. W., Nadin, A. An olefin metathesis based strategy for the construction of the JKL, OPQ, and UVW ring systems of maitotoxin Journal of the American Chemical Society  1996 118:10335-10336  DOI:10.1021/ja962862z
    • degree-related publication Nicolaou, K. C.*, Yue, E. W.*, Lagreca, S., Nadin, A., Yang, Z., Leresche, J. E., Tsuri, T., Naniwa, Y., Dericcardis, F. Synthesis of zaragozic acid A/squalestatin S1 Chemistry-a European Journal  1995 1:467-494  DOI:10.1002/chem.19950010712 (* = equal contribution)
    • degree-related publication Nicolaou, K. C., Nadin, A., Leresche, J. E., Lagreca, S., Tsuri, T., Yue, E. W., Yang, Z. Synthesis of the first fully functionalized core of the zaragozic acids squalestatins Angewandte Chemie-International Edition  1994 33:2187-2190  DOI:10.1002/anie.199421871
    • degree-related publication Nicolaou, K. C., Nadin, A., Leresche, J. E., Yue, E. W., Lagreca, S. Total synthesis of zaragozic-acid-A squalestatin-S1 Angewandte Chemie-International Edition  1994 33:2190-2191  DOI:10.1002/anie.199421901
    • degree-related publication Nicolaou, K. C.*, Yue, E. W.*, Naniwa, Y., Dericcardis, F., Nadin, A., Leresche, J. E., Lagreca, S., Yang, Z. Zaragozic-acid-A squalestatin-S1 - synthetic and retrosynthetic studies Angewandte Chemie-International Edition  1994 33:2184-2187  DOI:10.1002/anie.199421841 (* = equal contribution)
    • degree-related publication Nicolaou, K. C., Smith, A. L., Yue, E. W. Chemistry and biology of natural and designed enediynes Proceedings of the National Academy of Sciences of the United States of America  1993 90:5881-5888  DOI:10.1073/pnas.90.13.5881  PMID:8327459
    • Yue, E. W., Gerdes, J. M., Mathis, C. A. Synthesis of 2,3-dimethoxy-5-iodobenzoic acid Journal of Organic Chemistry  1991 56:5451-5456  DOI:10.1021/jo00018a048
  • chapter

    • Nicolaou, K. C., Yue, E. W., Oshima, T. New roads to molecular complexity The New Chemistry. 168-198. 2000
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Background

education and training

  • Ph.D. in Organic Chemistry, Scripps Research 1991 - 1996

advisee of

  • graduate advising relationship

    • Nicolaou, K.C., Ph.D.  candidacy, 1992 - 1996
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Contact

full name

  • Eddy Wai Tsun Yue

geographic location

  • Scripps California 

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