recent publications
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academic article
- Chen, M. R., Kuhle, B., Diedrich, J., Liu, Z., Moresco, J. J., Yates III, J. R., Pan, T., Yang, X. L. Cross-editing by a tRNA synthetase allows vertebrates to abundantly express mischargeable tRNA without causing mistranslation Nucleic Acids Research 2020 48:6445-6457 DOI:10.1093/nar/gkaa469 PMID:32484512 PMCID:PMC7337962
- Wang, J., Vallee, I., Dutta, A., Wang, Y., Mo, Z., Liu, Z., Cui, H., Su, A. I., Yang, X. L. Multi-Omics Database Analysis of Aminoacyl-tRNA Synthetases in Cancer Genes 2020 11 DOI:10.3390/genes11111384 PMID:33266490 PMCID:PMC7700366
- Morelli, K. H., Griffin, L. B., Pyne, N. K., Wallace, L. M., Fowler, A. M., Oprescu, S. N., Takase, R., Wei, N., Meyer-Schuman, R., Mellacheruvu, D., Kitzman, J. O., Kocen, S. G., et al. Allele-specific RNA interference prevents neuropathy in Charcot-Marie-Tooth disease type 2D mouse models Journal of Clinical Investigation 2019 129:5568-5583 DOI:10.1172/jci130600 PMID:31557132 PMCID:PMC6877339
- Bervoets, S., Wei, N., Erfurth, M. L., Yusein-Myashkova, S., Ermanoska, B., Mateiu, L., Asselbergh, B., Blocquel, D., Kakad, P., Penserga, T., Thomas, F. P., Guergueltcheva, V., et al. Transcriptional dysregulation by a nucleus-localized aminoacyl-tRNA synthetase associated with Charcot-Marie-Tooth neuropathy Nature Communications 2019 10 DOI:10.1038/s41467-019-12909-9 PMID:31695036 PMCID:PMC6834567
- Blocquel, D., Sun, L., Matuszekc, Z., Li, S., Weber, T., Kuhle, B., Kooi, G., Wei, N., Baets, J., Pan, T., Schimmel, P., Yang, X. L. CMT disease severity correlates with mutation-induced open conformation of histidyl-tRNA synthetase, not aminoacylation loss, in patient cells Proceedings of the National Academy of Sciences of the United States of America 2019 116:19440-19448 DOI:10.1073/pnas.1908288116 PMID:31501329
- Wei, N., Zhang, Q., Yang, X. L. Neurodegenerative Charcot-Marie-Tooth disease as a case study to decipher novel functions of aminoacyl-tRNA synthetases Journal of Biological Chemistry 2019 294:5321-5339 DOI:10.1074/jbc.REV118.002955 PMID:30643024 PMCID:PMC6462521
- Kanaji, T., Vo, M. N., Kanaji, S., Zarpellon, A., Shapiro, R., Morodomi, Y., Yuzuriha, A., Eto, K., Belani, R., Do, M. H., Yang, X. L., Ruggeri, Z. M., et al. Tyrosyl-tRNA synthetase stimulates thrombopoietin-independent hematopoiesis accelerating recovery from thrombocytopenia Proceedings of the National Academy of Sciences of the United States of America 2018 115:EB228-EB235 DOI:10.1073/pnas.1807000115 PMID:30104364 PMCID:PMC6126720
- Chong, Y. E., Guo, M., Yang, X. L., Kuhle, B., Naganuma, M., Sekine, S., Yokoyama, S., Schimmel, P. Distinct ways of G:U recognition by conserved tRNA binding motifs Proceedings of the National Academy of Sciences of the United States of America 2018 115:7527-7532 DOI:10.1073/pnas.1807109115 PMID:29967150 PMCID:PMC6055181
- Xu, Z., Lo, W. S., Beck, D. B., Schuch, L. A., Olahova, M., Kopajtich, R., Chong, Y. E., Alston, C. L., Seidl, E., Zhai, L., Lau, C. F., Timchak, D., et al. Bi-allelic mutations in phe-tRNA synthetase associated with a multi-system pulmonary disease Support non-translational function American Journal of Human Genetics 2018 103:100-114 DOI:10.1016/j.ajhg.2018.06.006 PMID:29979980 PMCID:PMC6035289
- Limsakul, P., Peng, Q., Wu, Y., Allen, M. E., Liang, J., Remacle, A. G., Lopez, T., Ge, X., Kay, B. K., Zhao, H. M., Strongin, A. Y., Yang, X. L., et al. Directed evolution to engineer monobody for FRET biosensor assembly and imaging at live-cell surface Cell Chemical Biology 2018 25:370-+ DOI:10.1016/j.chembiol.2018.01.002 PMID:29396288 PMCID:PMC5910193
- Mo, Z., Zhao, X., Liu, H., Hu, Q., Chen, X. Q., Pham, J., Wei, N., Liu, Z., Zhou, J., Burgess, R. W., Pfaff, S. L., Caskey, C. T., et al. Aberrant GlyRS-HDAC6 interaction linked to axonal transport deficits in Charcot-Marie-Tooth neuropathy Nature Communications 2018 9 DOI:10.1038/s41467-018-03461-z PMID:29520015 PMCID:PMC5843656
- Xu, X., Zhou, H., Zhou, Q., Hong, F., Vo, M. N., Niu, W., Wang, Z., Xiong, X., Nakamura, K., Wakasugi, K., Schimmel, P., Yang, X. L. An alternative conformation of human TrpRS suggests a role of zinc in activating non-enzymatic function Rna Biology 2018 15:649-658 DOI:10.1080/15476286.2017.1377868 PMID:28910573 PMCID:PMC6103731
- Sleigh, J. N., Gomez-Martin, A., Wei, N., Bai, G., Yang, X. L., Schiavo, G. Neuropilin 1 sequestration by neuropathogenic mutant glycyl-tRNA synthetase is permissive to vascular homeostasis Scientific Reports 2017 7 DOI:10.1038/s41598-017-10005-w
- Blocquel, D., Li, S., Wei, N., Daub, H., Sajish, M., Erfurth, M. L., Kooi, G., Zhou, J., Bai, G., Schimmel, P., Jordanova, A., Yang, X. L. Alternative stable conformation capable of protein misinteraction links tRNA synthetase to peripheral neuropathy Nucleic Acids Research 2017 45:8091-8104 DOI:10.1093/nar/gkx455 PMID:28531329
- Sleigh, J. N., Dawes, J. M., West, S. J., Wei, N., Spauldingd, E. L., Gomez-Martin, A., Zhang, Q., Burgess, R. W., Cader, M. Z., Talbot, K., Yang, X. L., Bennett, D. L., et al. Trk receptor signaling and sensory neuron fate are perturbed in human neuropathy caused by Gars mutations Proceedings of the National Academy of Sciences of the United States of America 2017 114:E3324-E3333 DOI:10.1073/pnas.1614557114 PMID:28351971 PMCID:PMC5402433
- Shi, Y., Wei, N., Yang, X. L. Studying nuclear functions of aminoacyl tRNA synthetases Methods 2017 113:105-110 DOI:10.1016/j.ymeth.2016.09.011 PMID:27664293 PMCID:PMC5300860
- Sun, L., Song, Y., Blocquel, D., Yang, X. L., Schimmel, P. Two crystal structures reveal design for repurposing the C-Ala domain of human AlaRS Proceedings of the National Academy of Sciences of the United States of America 2016 113:14300-14305 DOI:10.1073/pnas.1617316113 PMID:27911835 PMCID:PMC5167178
- Sun, L., Gomes, A. C., He, W., Zhou, H., Wang, X., Pan, D. W., Schimmel, P., Pan, T., Yang, X. L. Evolutionary gain of alanine mischarging to noncognate tRNAs with a G4:U69 base pair Journal of the American Chemical Society 2016 138:12948-12955 DOI:10.1021/jacs.6b07121 PMID:27622773
- Mo, Z., Zhang, Q., Liu, Z., Lauer, J., Shi, Y., Sun, L., Griffin, P. R. Neddylation requires glycyl-tRNA synthetase to protect activated E2 Nature Structural & Molecular Biology 2016 23:730-737 DOI:10.1038/nsmb.3250 PMID:27348078 PMCID:PMC4972647
- Wei, Z., Xu, Z., Liu, X., Lo, W. S., Ye, F., Lau, C. F., Wang, F., Zhou, J. J., Nangle, L. A., Yang, X. L., Zhang, M., Schimmel, P. Alternative splicing creates two new architectures for human tyrosyl-tRNA synthetase Nucleic Acids Research 2016 44:1247-1255 DOI:10.1093/nar/gkw002 PMID:26773056 PMCID:PMC4756856
- He, W., Bai, G., Zhou, H., Wei, N., White, N. M., Lauer, J., Liu, H., Shi, Y., Dumitru, C. D., Lettieri, K., Shubayev, V., Jordanova, A., et al. CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase Nature 2015 526:710-714 DOI:10.1038/nature15510 PMID:26503042 PMCID:PMC4754353
- Niehues, S., Bussmann, J., Steffes, G., Erdmann, I., Kohrer, C., Sun, L., Wagner, M., Schafer, K., Wang, G., Koerdt, S. N., Stum, M., RajBhandary, U. L., et al. Impaired protein translation in Drosophila models for Charcot-Marie-Tooth neuropathy caused by mutant tRNA synthetases Nature Communications 2015 6:7520 DOI:10.1038/ncomms8520 PMID:26138142 PMCID:PMC4506996
- Yang, X. L. tRNA-derived G-quadruplex protects motor neurons Proceedings of the National Academy of Sciences of the United States of America 2014 111:18108-18109 DOI:10.1073/pnas.1420838111 PMID:25512555 PMCID:PMC4280617
- Wei, N., Shi, Y., Truong, L. N., Fisch, K. M., Xu, T., Gardiner, E., Fu, G., Hsu, Y. S. O., Kishi, S., Su, A. I., Wu, X., Yang, X. L. Oxidative stress diverts tRNA synthetase to nucleus for protection against DNA damage Molecular Cell 2014 56:323-332 DOI:10.1016/j.molcel.2014.09.006 PMID:25284223 PMCID:PMC4224670
- Ishimura, R., Nagy, G., Dotu, I., Zhou, H., Yang, X. L., Schimmel, P., Senju, S., Nishimura, Y., Chuang, J. H., Ackerman, S. L. Ribosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration Science 2014 345:455-459 DOI:10.1126/science.1249749 PMID:25061210 PMCID:PMC4281038
- Lo, W. S., Gardiner, E., Xu, Z., Lau, C. F., Wang, F., Zhou, J. J., Mendlein, J. D., Nangle, L. A., Chiang, K. P., Yang, X. L., Au, K. F., Wong, W. H., et al. Human tRNA synthetase catalytic nulls with diverse functions Science 2014 345:328-332 DOI:10.1126/science.1252943 PMID:25035493 PMCID:PMC4188629
- Zhou, J. J., Wang, F., Xu, Z., Lo, W. S., Lau, C. F., Chiang, K. P., Nangle, L. A., Ashlock, M. A., Mendlein, J. D., Yang, X. L., Zhang, M., Schimmel, P. Secreted histidyl-tRNA synthetase splice variants elaborate major epitopes for autoantibodies in inflammatory myositis Journal of Biological Chemistry 2014 289:19269-19275 DOI:10.1074/jbc.C114.571026 PMID:24898250 PMCID:PMC4094037
- Naganuma, M., Sekine, S., Chong, Y. E., Guo, M., Yang, X. L., Gamper, H., Hou, Y. M., Schimmel, P., Yokoyama, S. The selective tRNA aminoacylation mechanism based on a single G.U pair Nature 2014 510:507-511 DOI:10.1038/nature13440 PMID:24919148 PMCID:PMC4323281
- Shi, Y., Xu, X., Zhang, Q., Fu, G., Mo, Z., Wang, G. S., Kishi, S., Yang, X. L. tRNA synthetase counteracts c-Myc to develop functional vasculature Elife 2014 3:e02349 DOI:10.7554/eLife.02349 PMID:24940000 PMCID:PMC4057782
- Guo, M., Yang, X. L. Architecture and metamorphosis Topics in Current Chemistry 2014 344:89-118 DOI:10.1007/128_2013_424 PMID:23536245 PMCID:PMC3864538
- Xu, X., Shi, Y., Yang, X. L. Crystal structure of human seryl-tRNA synthetase and Ser-SA complex reveals a molecular lever specific to higher eukaryotes Structure 2013 21:2078-2086 DOI:10.1016/j.str.2013.08.021 PMID:24095058 PMCID:PMC3825832
- Gonzalez, M., McLaughlin, H., Houlden, H., Guo, M., Yo-Tsen, L., Hadjivassilious, M., Speziani, F., Yang, X. L., Antonellis, A., Reilly, M. M., Zuchner, S., Inherited Neuropathy Consortium (INC) Exome sequencing identifies a significant variant in methionyl-tRNA synthetase (MARS) in a family with late-onset CMT2 Journal of Neurology Neurosurgery and Psychiatry 2013 84:1247-1249 DOI:10.1136/jnnp-2013-305049 PMID:23729695 PMCID:PMC3796032
- Wang, F., Xu, Z., Zhou, J., Lo, W. S., Lau, C. F., Nangle, L. A., Yang, X. L., Zhang, M., Schimmel, P. Regulated capture by exosomes of mRNAs for cytoplasmic tRNA synthetases Journal of Biological Chemistry 2013 288:29223-29228 DOI:10.1074/jbc.C113.490599 PMID:24003230 PMCID:PMC3795223
- Yang, X. L. Structural disorder in expanding the functionome of aminoacyl-tRNA synthetases Chemistry & Biology 2013 20:1093-1099 DOI:10.1016/j.chembiol.2013.07.013 PMID:24054183 PMCID:PMC3782743
- Zhou, H. H., Sun, L. T., Yang, X. L., Schimmel, P. ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase Nature 2013 494:121-124 DOI:10.1038/nature11774 PMID:23263184 PMCID:PMC3569068
- Ofir-Birin, Y., Fang, P. F., Bennett, S. P., Zhang, H. M., Wang, J., Rachmin, I., Shapiro, R., Song, J., Dagan, A., Pozo, J., Kim, S., Marshall, A. G., et al. Structural switch of lysyl-tRNA synthetase between translation and transcription Molecular Cell 2013 49:30-42 DOI:10.1016/j.molcel.2012.10.010 PMID:23159739 PMCID:PMC3766370
- Xu, Z. W., Wei, Z. Y., Zhou, J. J., Ye, F., Lo, W. S., Wang, F., Lau, C. F., Wu, J. J., Nangle, L. A., Chiang, K. P., Yang, X. L., Zhang, M. J., et al. Internally deleted human tRNA synthetase suggests evolutionary pressure for repurposing Structure 2012 20:1470-1477 DOI:10.1016/j.str.2012.08.001 PMID:22958643 PMCID:PMC3485694
- Lee, P. S., Zhang, H. M., Marshall, A. G., Yang, X. L., Schimmel, P. Uncovering of a short internal peptide activates a tRNA synthetase procytokine Journal of Biological Chemistry 2012 287:20504-20508 DOI:10.1074/jbc.C112.369439 PMID:22549774 PMCID:PMC3370235
- Sajish, M., Zhou, Q. S., Kishi, S., Valdez, D. M., Kapoor, M., Guo, M., Lee, S., Kim, S., Yang, X. L., Schimmel, P. Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling Nature Chemical Biology 2012 8:547-554 DOI:10.1038/nchembio.937 PMID:22504299 PMCID:PMC3780985
- Fu, G. S., Xu, T., Shi, Y., Wei, N., Yang, X. L. tRNA-controlled nuclear import of a human tRNA synthetase Journal of Biological Chemistry 2012 287:9330-9334 DOI:10.1074/jbc.C111.325902 PMID:22291016 PMCID:PMC3308776
- Park, M. C., Kang, T., Jin, D., Han, J. M., Kim, S. B., Park, Y. J., Cho, K., Park, Y. W., Guo, M., He, W., Yang, X. L., Schimmel, P., et al. Secreted human glycyl-tRNA synthetase implicated in defense against ERK-activated tumorigenesis Proceedings of the National Academy of Sciences of the United States of America 2012 109:E640-E647 DOI:10.1073/pnas.1200194109 PMID:22345558 PMCID:PMC3306665
- Xu, X. L., Shi, Y., Zhang, H. M., Swindell, E. C., Marshall, A. G., Guo, M., Kishi, S., Yang, X. L. Unique domain appended to vertebrate tRNA synthetase is essential for vascular development Nature Communications 2012 3:681 DOI:10.1038/ncomms1686 PMID:22353712 PMCID:PMC3293412
- Motley, W. W., Seburn, K. L., Nawaz, M. H., Miers, K. E., Cheng, J., Antonellis, A., Green, E. D., Talbot, K., Yang, X. L., Fischbeck, K. H., Burgess, R. W. Charcot-Marie-Tooth-linked mutant GARS is toxic to peripheral neurons independent of wild-type GARS levels PLoS Genetics 2011 7:e1002399 DOI:10.1371/journal.pgen.1002399 PMID:22144914 PMCID:PMC3228828
- Yang, X. L., Schimmel, P. Functional expansion of the tRNA world under stress Molecular Cell 2011 43:500-502 DOI:10.1016/j.molcel.2011.08.004 PMID:21855789 PMCID:PMC3163667
- He, W., Zhang, H. M., Chong, Y. E., Guo, M., Marshall, A. G., Yang, X. L. Dispersed disease-causing neomorphic mutations on a single protein promote the same localized conformational opening Proceedings of the National Academy of Sciences of the United States of America 2011 108:12307-12312 DOI:10.1073/pnas.1104293108 PMID:21737751 PMCID:PMC3145702
- Fang, P. F., Zhang, H. M., Shapiro, R., Marshall, A. G., Schimmel, P., Yang, X. L., Guo, M. Structural context for mobilization of a human tRNA synthetase from its cytoplasmic complex Proceedings of the National Academy of Sciences of the United States of America 2011 108:8239-8244 DOI:10.1073/pnas.1100224108 PMID:21536907 PMCID:PMC3100937
- Vo, M. N., Yang, X. L., Schimmel, P. Dissociating quaternary structure regulates cell-signaling functions of a secreted human tRNA synthetase Journal of Biological Chemistry 2011 286:11563-11568 DOI:10.1074/jbc.C110.213876 PMID:21310955 PMCID:PMC3064210
- Nawaz, M. H., Merriman, E., Yang, X. L., Schimmel, P. p23(H) implicated as cis/trans regulator of AlaXp-directed editing for mammalian cell homeostasis Proceedings of the National Academy of Sciences of the United States of America 2011 108:2723-2728 DOI:10.1073/pnas.1019400108 PMID:21285375 PMCID:PMC3041069
- Guo, M., Shapiro, R., Morris, G. M., Yang, X. L., Schimmel, P. Packaging HIV virion components through dynamic equilibria of a human tRNA synthetase Journal of Physical Chemistry B 2010 114:16273-16279 DOI:10.1021/jp1082517 PMID:21058683 PMCID:PMC3042951
- Han, G. W., Yang, X. L., McMullan, D., Chong, Y. E., Krishna, S. S., Rife, C. L., Weekes, D., Brittain, S. M., Abdubek, P., Ambing, E., Astakhova, T., Axelrod, H. L., et al. Structure of a tryptophanyl-tRNA synthetase containing an iron-sulfur cluster Acta Crystallographica Section F-Structural Biology and Crystallization Communications 2010 66:1326-1334 DOI:10.1107/s1744309110037619 PMID:20944229 PMCID:PMC2954223
- Guo, M., Yang, X. L., Schimmel, P. New functions of aminoacyl-tRNA synthetases beyond translation Nature Reviews Molecular Cell Biology 2010 11:668-674 DOI:10.1038/nrm2956 PMID:20700144 PMCID:PMC3042954
- Guo, M., Shapiro, R., Schimmel, P., Yang, X. L. Introduction of a leucine half-zipper engenders multiple high-quality crystals of a recalcitrant tRNA synthetase Acta Crystallographica Section D-Biological Crystallography 2010 66:243-250 DOI:10.1107/s0907444909055462 PMID:20179335 PMCID:PMC2827346
- Guo, M., Schimmel, P., Yang, X. L. Functional expansion of human tRNA synthetases achieved by structural inventions FEBS Letters 2010 584:434-442 DOI:10.1016/j.febslet.2009.11.064 PMID:19932696 PMCID:PMC2826164
- Zhou, Q. S., Kapoor, M., Guo, M., Belani, R., Xu, X. L., Kiosses, W. B., Hanan, M., Park, C., Armour, E., Do, M. H., Nangle, L. A., Schimmel, P., et al. Orthogonal use of a human tRNA synthetase active site to achieve multifunctionality Nature Structural & Molecular Biology 2010 17:57-61 DOI:10.1038/nsmb.1706 PMID:20010843 PMCID:PMC3042952
- Guo, M., Chong, Y. E., Shapiro, R., Beebe, K., Yang, X. L., Schimmel, P. Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma Nature 2009 462:808-812 DOI:10.1038/nature08612 PMID:20010690 PMCID:PMC2799227
- Guo, R. T., Chong, Y. E., Guo, M., Yang, X. L. Crystal structures and biochemical analyses suggest a unique mechanism and role for human glycyl-tRNA synthetase in Ap4A homeostasis Journal of Biological Chemistry 2009 284:28968-28976 DOI:10.1074/jbc.M109.030692 PMID:19710017 PMCID:PMC2781443
- Storkebaum, E., Leitao-Goncalves, R., Godenschwege, T., Nangle, L., Mejia, M., Bosmans, I., Ooms, T., Jacobs, A., Van Dijck, P., Yang, X. L., Schimmel, P., Norga, K., et al. Dominant mutations in the tyrosyl-tRNA synthetase gene recapitulate in Drosophila features of human Charcot-Marie-Tooth neuropathy Proceedings of the National Academy of Sciences of the United States of America 2009 106:11782-11787 DOI:10.1073/pnas.0905339106 PMID:19561293 PMCID:PMC2702257
- Kapoor, M., Otero, F. J., Slike, B. M., Ewalt, K. L., Yang, X. L. Mutational separation of aminoacylation and cytokine activities of human tyrosyl-tRNA synthetase Chemistry & Biology 2009 16:531-539 DOI:10.1016/j.chembiol.2009.03.006 PMID:19477417 PMCID:PMC2706086
- Guo, M., Chong, Y. E., Beebe, K., Shapiro, R., Yang, X. L., Schimmel, P. The C-Ala domain brings together editing and aminoacylation functions on one tRNA Science 2009 325:744-747 DOI:10.1126/science.1174343 PMID:19661429 PMCID:PMC4559334
- Chong, Y. E., Yang, X. L., Schimmel, P. Natural homolog of tRNA synthetase editing domain rescues conditional lethality caused by mistranslation Journal of Biological Chemistry 2008 283:30073-30078 DOI:10.1074/jbc.M805943200 PMID:18723508 PMCID:PMC2573062
- Cheng, G., Zhang, H., Yang, X. L., Tzima, E., Ewalt, K. L., Schimmel, P., Faber, J. E. Effect of mini-tyrosyl-tRNA synthetase on ischemic angiogenesis, leukocyte recruitment, and vascular permeability American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2008 295:R1138-R1146 DOI:10.1152/ajpregu.90519.2008 PMID:18753262
- Greenberg, Y., King, M., Kiosses, W. B., Ewalt, K., Yang, X., Schimmel, P., Reader, J. S., Tzima, E. The novel fragment of tyrosyl tRNA synthetase, mini-TyrRS, is secreted to induce an angiogenic response in endothelial cells FASEB Journal 2008 22:1597-1605 DOI:10.1096/fj.07-9973com PMID:18165356
- Guo, M., Ignatov, M., Musier-Forsyth, K., Schimmel, P., Yang, X. L. Crystal structure of tetrameric form of human lysyl-tRNA synthetase: implications for multisynthetase complex formation Proceedings of the National Academy of Sciences of the United States of America 2008 105:2331-2336 DOI:10.1073/pnas.0712072105 PMID:18272479 PMCID:PMC2268136
- Kapoor, M., Zhou, Q., Otero, F., Myers, C. A., Bates, A., Belani, R., Liu, J., Luo, J. K., Tzima, E., Zhang, D. E., Yang, X. L., Schimmel, P. Evidence for annexin II-S100A10 complex and plasmin in mobilization of cytokine activity of human TrpRS Journal of Biological Chemistry 2008 283:2070-2077 DOI:10.1074/jbc.M706028200 PMID:17999956
- Yang, X. L., Kapoor, M., Otero, F. J., Slike, B. M., Tsuruta, H., Frausto, R., Bates, A., Ewalt, K. L., Cheresh, D. A., Schimmel, P. Gain-of-function mutational activation of human tRNA synthetase procytokine Chemistry & Biology 2007 14:1323-1333 DOI:10.1016/j.chembiol.2007.10.016 PMID:18096501 PMCID:PMC2693404
- Nangle, L. A., Zhang, W., Xie, W., Yang, X. L., Schimmel, P. Charcot-Marie-Tooth disease-associated mutant tRNA synthetases linked to altered dimer interface and neurite distribution defect Proceedings of the National Academy of Sciences of the United States of America 2007 104:11239-11244 DOI:10.1073/pnas.0705055104 PMID:17595294 PMCID:PMC2040883
- Yang, X. L., Guo, M., Kapoor, M., Ewalt, K. L., Otero, F. J., Skene, R. J., McRee, D. E., Schimmel, P. Functional and crystal structure analysis of active site adaptations of a potent anti-angiogenic human tRNA synthetase Structure 2007 15:793-805 DOI:10.1016/j.str.2007.05.009 PMID:17637340 PMCID:PMC2104486
- Xie, W., Nangle, L. A., Zhang, W., Schimmel, P., Yang, X. L. Long-range structural effects of a Charcot-Marie-Tooth disease-causing mutation in human glycyl-tRNA synthetase Proceedings of the National Academy of Sciences of the United States of America 2007 104:9976-9981 DOI:10.1073/pnas.0703908104 PMID:17545306 PMCID:PMC1891255
- Xie, W., Schimmel, P., Yang, X. L. Crystallization and preliminary X-ray analysis of a native human tRNA synthetase whose allelic variants are associated with Charcot-Marie-Tooth disease Acta Crystallographica Section F-Structural Biology and Crystallization Communications 2006 62:1243-1246 DOI:10.1107/s1744309106046434 PMID:17142907 PMCID:PMC2225372
- Schimmel, P., Yang, X. L. Perfecting the genetic code with an RNP complex Structure 2006 14:1729-1730 DOI:10.1016/j.str.2006.11.002 PMID:17161363
- Yang, X. L., Otero, F. J., Ewalt, K. L., Liu, J. M., Swairjo, M. A., Kohrer, C., RajBhandary, U. L., Skene, R. J., McRee, D. E., Schimmel, P. Two conformations of a crystalline human tRNA synthetase–tRNA complex: implications for protein synthesis EMBO Journal 2006 25:2919-2929 DOI:10.1038/sj.emboj.7601154 PMID:16724112 PMCID:PMC1500858
- Ewalt, K. L., Yang, X. L., Otero, F. J., Liu, J. M., Slike, B., Schimmel, P. Variant of human enzyme sequesters reactive intermediate Biochemistry 2005 44:4216-4221 DOI:10.1021/bi048116l PMID:15766249
- Yang, X. L., Schimmel, P., Ewalt, K. L. Relationship of two human tRNA synthetases used in cell signaling Trends in Biochemical Sciences 2004 29:250-256 DOI:10.1016/j.tibs.2004.03.002 PMID:15130561
- Swairjo, M. A., Otero, F. J., Yang, X. L., Lovato, M. A., Skene, R. J., McRee, D. E., Ribas de Pouplana, L., Schimmel, P. Alanyl-tRNA synthetase crystal structure and design for acceptor-stem recognition Molecular Cell 2004 13:829-841 DOI:10.1016/s1097-2765(04)00126-1 PMID:15053876
- Schimmel, P., Yang, X. L. Two classes give lessons about CCA Nature Structural & Molecular Biology 2004 11:807-808 DOI:10.1038/nsmb0904-807 PMID:15332079
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