Xue, Song

Graduate Student

Positions

2018 - Faculty Member, Beijing University of Chemical Technology

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- Xue, S., Kallupi, M., Zhou, B., Smith, L. C., Miranda, P. O., George, O., Janda, K. D. An enzymatic advance in nicotine cessation therapy Chemical Communications 2018 54:1686-1689 DOI:10.1039/c7cc09134f PMID:29308799
- Kallupi, M., Xue, S., Zhou, B., Janda, K. D., George, O. An enzymatic approach reverses nicotine dependence, decreases compulsive-like intake, and prevents relapse Science Advances 2018 4 DOI:10.1126/sciadv.aat4751 PMID:30345354 PMCID:PMC6192681
- Tararina, M. A., Xue, S., Smith, L. C., Muellers, S. N., Miranda, P. O., Janda, K. D., Allen, K. N. Crystallography coupled with kinetic analysis provides mechanistic underpinnings of a nicotine-degrading enzyme Biochemistry 2018 57:3741-3751 DOI:10.1021/acs.biochem.8b00384 PMID:29812904
- Xue, S., Seki, H., Remes, M., Silhar, P., Janda, K. Examination of α-exosite inhibitors against Botulinum neurotoxin A protease through structure-activity relationship studies of chicoric acid Bioorganic & Medicinal Chemistry Letters 2017 27:4956-4959 DOI:10.1016/j.bmcl.2017.10.021 PMID:29050781 PMCID:PMC5667901
- Seki, H., Xue, S., Pellet, S., Silhar, P., Johnson, E. A., Janda, K. D. Cellular protection of SNAP-25 against botulinum neurotoxin/A: inhibition of thioredoxin reductase through a suicide substrate mechanism Journal of the American Chemical Society 2016 138:5568-5575 DOI:10.1021/jacs.5b12929 PMID:27070533 PMCID:PMC4881748
- Bremer, P. T., Xue, S., Janda, K. D. Picolinic acids as β-exosite inhibitors of botulinum neurotoxin A light chain Chemical Communications 2016 52:12521-12524 DOI:10.1039/c6cc06749b PMID:27722252 PMCID:PMC5085802
- Sue, S., Schlosburg, J. E., Janda, K. D. A new strategy for smoking cessation: characterization of a bacterial enzyme for the degradation of nicotine Journal of the American Chemical Society 2015 137:10136-10139 DOI:10.1021/jacs.5b06605 PMID:26237398
- Seki, H., Xue, S., Hixon, M. S., Pellett, S., Remes, M., Johnson, E. A., Janda, K. D. Toward the discovery of dual inhibitors for botulinum neurotoxin A: concomitant targeting of endocytosis and light chain protease activity Chemical Communications 2015 51:6226-6229 DOI:10.1039/c5cc00677e PMID:25759983
- Xue, S., Javor, S., Hixon, M. S., Janda, K. D. Probing BoNT/A protease exosites: implications for inhibitor design and light chain longevity Biochemistry 2014 53:6820-6824 DOI:10.1021/bi500950x PMID:25295706 PMCID:PMC4222541