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Xie, Jia
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Xie, Jia

Non-Faculty Academic
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Positions

  • 2017 - Senior Staff Scientist, Molecular Medicine , Scripps Research
  • 2016 - 2017 Senior Staff Scientist, Cell and Molecular Biology (CMB) , Scripps Research
  • 2011 - 2015 Postdoctoral Fellow, Cell and Molecular Biology (CMB) , Scripps Research

Contact

  • jiaxie@scripps.edu

Websites

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Publications

recent publications
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  • academic article

    • Meng, B., Lan, K., Xie, J., Lerner, R. A., Wilson, I. A., Yang, B. Inhibitory antibodies identify unique sites of therapeutic vulnerability in rhinovirus and other enteroviruses Proceedings of the National Academy of Sciences of the United States of America  2020 117:13499-13508  DOI:10.1073/pnas.1918844117  PMID:32467165  PMCID:PMC7306783
    • Hong, S. L., Grande, G., Yu, C. H., Chapla, D. G., Reigh, N., Yang, J. Y., Yang, Y., Izumori, K., Moremen, K. W., Xie, J., Wu, P. hFUT1-Based Live-Cell Assay To Profile α1-2-Fucoside-Enhanced Influenza Virus A Infection ACS Chemical Biology  2020 15:819-823  DOI:10.1021/acschembio.9b00869  PMID:32271008
    • Lin, C. W., Xie, J., Zhang, D., Han, K. H., Grande, G., Wu, N. C., Yang, Z., Yea, K., Lerner, R. A. Immunity against cancer cells may promote their proliferation and metastasis Proceedings of the National Academy of Sciences of the United States of America  2020 117:426-431  DOI:10.1073/pnas.1916833117  PMID:31871166  PMCID:PMC6955299
    • Blanchard, J. W., Xie, J., El-Mecharrafie, N., Gross, S., Lee, S., Lerner, R. A., Baldwin, K. K. Replacing reprogramming factors with antibodies selected from combinatorial antibody libraries Nature Biotechnology  2017 35:960-968  DOI:10.1038/nbt.3963  PMID:28892074
    • Wu, N. C., Grande, G., Turner, H. L., Ward, A. B., Xie, J., Lerner, R. A., Wilson, I. A. In vitro evolution of an influenza broadly neutralizing antibody is modulated by hemagglutinin receptor specificity Nature Communications  2017 8  DOI:10.1038/ncomms15371  PMID:28504265  PMCID:PMC5440694
    • Xie, J., Sok, D., Wu, N. C., Zheng, T., Zhang, W., Burton, D. R., Lerner, R. A. Immunochemical engineering of cell surfaces to generate virus resistance Proceedings of the National Academy of Sciences of the United States of America  2017 114:4655-4660  DOI:10.1073/pnas.1702764114  PMID:28396429  PMCID:PMC5422804
    • Wu, N. C., Xie, J., Zheng, T., Nycholat, C. M., Grande, G., Paulson, J. C., Lerner, R. A., Wilson, I. A. Diversity of functionally permissive sequences in the receptor-binding site of influenza hemagglutinin Cell Host & Microbe  2017 21:742-753  DOI:10.1016/j.chom.2017.05.011  PMID:28618270
    • Zhang, H., Sturchler, E., Zhu, J., Nieto, A., Cistrone, P. A., Xie, J., He, L., Yea, K., Jones, T., Turn, R., Di Stefano, P. S., Griffin, P. R., et al. Autocrine selection of a GLP-1R G-protein biased agonist with potent antidiabetic effects Nature Communications  2015 6:8918  DOI:10.1038/ncomms9918  PMID:26621478  PMCID:PMC4686834
    • Berton, F., Fallahi, M., Francesconi, W., Jones, T. M., Lerner, R. A., Lin, C. W., Sauer, K., Xie, J., Yea, K., Zhang, H. Agonist antibody that induces human malignant cells to kill one another Proceedings of the National Academy of Sciences of the United States of America  2015 112:E6158-E6165  DOI:10.1073/pnas.1519079112  PMID:26487683  PMCID:PMC4653151
    • Lerner, R. A., Grover, R. K., Zhang, H., Xie, J., Han, K. H., Peng, Y., Yea, K. Antibodies from combinatorial libraries use functional receptor pleiotropism to regulate cell fates Quarterly Reviews of Biophysics  2015 48:389-394  DOI:10.1017/s0033583515000049  PMID:26537396
    • Yea, K., Xie, J., Zhang, H., Zhang, W., Lerner, R. A. Selection of multiple agonist antibodies from intracellular combinatorial libraries reveals that cellular receptors are functionally pleiotropic Current Opinion in Chemical Biology  2015 26:1-7  DOI:10.1016/j.cbpa.2015.01.002  PMID:25621729
    • Lerner, R. A., Xie, J., Zhang, H. A proximity based general method for identification of ligand and receptor interactions in living cells Biochemical and Biophysical Research Communications  2014 454:251-255  DOI:10.1016/j.bbrc.2014.10.085  PMID:25451250
    • Yea, K., Zhang, H., Moldt, B., He, L., Zhu, J., Lerner, R. A. Prevention of cell death by antibodies selected from intracellular combinatorial libraries Chemistry & Biology  2014 21:274-283  DOI:10.1016/j.chembiol.2013.12.006  PMID:24440080
    • Yea, K., Zhang, H. K., Xie, J., Jones, T. M., Yang, G., Song, B. D., Lerner, R. A. Converting stem cells to dendritic cells by agonist antibodies from unbiased morphogenic selections Proceedings of the National Academy of Sciences of the United States of America  2013 110:14966-14971  DOI:10.1073/pnas.1313671110  PMID:23980154  PMCID:PMC3773771
    • Zhang, H., Yea, K., Ruiz, D., Wilson, I. A., Lerner, R. A. Selecting agonists from single cells infected with combinatorial antibody libraries Chemistry & Biology  2013 20:734-741  DOI:10.1016/j.chembiol.2013.04.012  PMID:23706638
    • Xie, J., Zhang, H., Yea, K., Lerner, R. A. Autocrine signaling based selection of combinatorial antibodies that transdifferentiate human stem cells Proceedings of the National Academy of Sciences of the United States of America  2013 110:8099-8104  DOI:10.1073/pnas.1306263110  PMID:23613575  PMCID:PMC3657831
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Background

education and training

  • Ph.D. in Cell and Molecular Biology, The University of Connecticut Health Center 2006 - 2011
  • M.S. in Biochemistry and Molecular Biology, Nankai University 2003 - 2006
  • B.E. in Bioengineering, Hebei University of Technology 1999 - 2003
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Contact

full name

  • Jia Xie

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