recent publications
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academic article
- Lin, C. W., Xie, J., Zhang, D., Han, K. H., Grande, G., Wu, N. C., Yang, Z., Yea, K., Lerner, R. A. Immunity against cancer cells may promote their proliferation and metastasis Proceedings of the National Academy of Sciences of the United States of America 2020 117:426-431 DOI:10.1073/pnas.1916833117 PMID:31871166 PMCID:PMC6955299
- Wu, N. C., Xie, J., Zheng, T., Nycholat, C. M., Grande, G., Paulson, J. C., Lerner, R. A., Wilson, I. A. Diversity of functionally permissive sequences in the receptor-binding site of influenza hemagglutinin Cell Host & Microbe 2017 21:742-753 DOI:10.1016/j.chom.2017.05.011 PMID:28618270
- Xie, J., Sok, D., Wu, N. C., Zheng, T., Zhang, W., Burton, D. R., Lerner, R. A. Immunochemical engineering of cell surfaces to generate virus resistance Proceedings of the National Academy of Sciences of the United States of America 2017 114:4655-4660 DOI:10.1073/pnas.1702764114 PMID:28396429 PMCID:PMC5422804
- Wu, N. C., Grande, G., Turner, H. L., Ward, A. B., Xie, J., Lerner, R. A., Wilson, I. A. In vitro evolution of an influenza broadly neutralizing antibody is modulated by hemagglutinin receptor specificity Nature Communications 2017 8 DOI:10.1038/ncomms15371 PMID:28504265 PMCID:PMC5440694
- Blanchard, J. W., Xie, J., El-Mecharrafie, N., Gross, S., Lee, S., Lerner, R. A., Baldwin, K. K. Replacing reprogramming factors with antibodies selected from combinatorial antibody libraries Nature Biotechnology 2017 35:960-968 DOI:10.1038/nbt.3963 PMID:28892074
- Berton, F., Fallahi, M., Francesconi, W., Jones, T. M., Lerner, R. A., Lin, C. W., Sauer, K., Xie, J., Yea, K., Zhang, H. Agonist antibody that induces human malignant cells to kill one another Proceedings of the National Academy of Sciences of the United States of America 2015 112:E6158-E6165 DOI:10.1073/pnas.1519079112 PMID:26487683 PMCID:PMC4653151
- Lerner, R. A., Grover, R. K., Zhang, H., Xie, J., Han, K. H., Peng, Y., Yea, K. Antibodies from combinatorial libraries use functional receptor pleiotropism to regulate cell fates Quarterly Reviews of Biophysics 2015 48:389-394 DOI:10.1017/s0033583515000049 PMID:26537396
- Zhang, H., Sturchler, E., Zhu, J., Nieto, A., Cistrone, P. A., Xie, J., He, L., Yea, K., Jones, T., Turn, R., Di Stefano, P. S., Griffin, P. R., et al. Autocrine selection of a GLP-1R G-protein biased agonist with potent antidiabetic effects Nature Communications 2015 6:8918 DOI:10.1038/ncomms9918 PMID:26621478 PMCID:PMC4686834
- Yea, K., Xie, J., Zhang, H., Zhang, W., Lerner, R. A. Selection of multiple agonist antibodies from intracellular combinatorial libraries reveals that cellular receptors are functionally pleiotropic Current Opinion in Chemical Biology 2015 26:1-7 DOI:10.1016/j.cbpa.2015.01.002 PMID:25621729
- Lerner, R. A., Xie, J., Zhang, H. A proximity based general method for identification of ligand and receptor interactions in living cells Biochemical and Biophysical Research Communications 2014 454:251-255 DOI:10.1016/j.bbrc.2014.10.085 PMID:25451250
- Yea, K., Zhang, H., Moldt, B., He, L., Zhu, J., Lerner, R. A. Prevention of cell death by antibodies selected from intracellular combinatorial libraries Chemistry & Biology 2014 21:274-283 DOI:10.1016/j.chembiol.2013.12.006 PMID:24440080
- Xie, J., Zhang, H., Yea, K., Lerner, R. A. Autocrine signaling based selection of combinatorial antibodies that transdifferentiate human stem cells Proceedings of the National Academy of Sciences of the United States of America 2013 110:8099-8104 DOI:10.1073/pnas.1306263110 PMID:23613575 PMCID:PMC3657831
- Yea, K., Zhang, H. K., Xie, J., Jones, T. M., Yang, G., Song, B. D., Lerner, R. A. Converting stem cells to dendritic cells by agonist antibodies from unbiased morphogenic selections Proceedings of the National Academy of Sciences of the United States of America 2013 110:14966-14971 DOI:10.1073/pnas.1313671110 PMID:23980154 PMCID:PMC3773771
- Zhang, H., Yea, K., Ruiz, D., Wilson, I. A., Lerner, R. A. Selecting agonists from single cells infected with combinatorial antibody libraries Chemistry & Biology 2013 20:734-741 DOI:10.1016/j.chembiol.2013.04.012 PMID:23706638