recent publications
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academic article
- Hu, Q., Lu, H., Wang, H., Li, S., Truong, L., Li, J., Liu, S., Xiang, R., Wu, X. Break-induced replication plays a prominent role in long-range repeat-mediated deletion EMBO Journal 2019 DOI:10.15252/embj.2019101751 PMID:31571254
- Xu, Y., Li, N., Xiang, R., Sun, P. Emerging roles of the p38 MAPK and PI3K/AKT/mTOR pathways in oncogene-induced senescence Trends in Biochemical Sciences 2014 39:268-276 DOI:10.1016/j.tibs.2014.04.004 PMID:24818748 PMCID:PMC4358807
- Chen, S., Li, X., Lu, D., Xu, Y., Mou, W., Wang, L., Chen, Y., Liu, Y., Li, X., Li, L. Y., Liu, L., Stupack, D., et al. SOX2 regulates apoptosis through MAP4K4-survivin signaling pathway in human lung cancer cells Carcinogenesis 2014 35:613-623 DOI:10.1093/carcin/bgt371 PMID:24233838
- Kwong, J., Chen, M., Lv, D., Luo, N., Su, W. J., Xiang, R., Sun, P. Q. Induction of p38δ expression plays an essential role in oncogenic ras-induced senescence Molecular and Cellular Biology 2013 33:3780-3794 DOI:10.1128/mcb.00784-13 PMID:23878395 PMCID:PMC3811880
- Yang, J., Liao, D. B., Chen, C., Liu, Y., Chuang, T. H., Xiang, R., Markowitz, D., Reisfeld, R. A., Luo, Y. P. Tumor-associated macrophages regulate murine breast cancer stem cells through a novel paracrine egfr/stat3/sox-2 signaling pathway Stem Cells 2013 31:248-258 DOI:10.1002/stem.1281 PMID:23169551
- Zhang, Z. H., Yin, J., Zhang, C. Y., Liang, N., Bai, N., Chang, A. T., Liu, Y. H., Li, Z. J., Tan, X. Y., Li, N., Lv, D., Xiang, R., et al. Activating transcription factor 4 increases chemotherapeutics resistance of human hepatocellular carcinoma Cancer Biology & Therapy 2012 13:435-442 DOI:10.4161/cbt.13.6.19295 PMID:22338651
- Liu, J., Xu, C. F., Liu, Y. L., Matsuo, H., Hsieh, R. P. F., Lo, J. F., Tseng, P. H., Yuan, C. J., Luo, Y. P., Xiang, R., Chuang, T. H. Activation of rabbit tlr9 by different cpg-odn optimized for mouse and human tlr9 Comparative Immunology Microbiology and Infectious Diseases 2012 35:443-451 DOI:10.1016/j.cimid.2012.03.008 PMID:22560893
- Zhou, M. Q., Wang, L. N., Su, W. J., Tong, L. L., Liu, Y. H., Fan, Y., Luo, N., Zheng, Y. Z., Zhao, H., Xiang, R., Li, Z. J. Assessment of therapeutic efficacy of liposomal nanoparticles mediated gene delivery by molecular imaging for cancer therapy Journal of Biomedical Nanotechnology 2012 8:742-750 DOI:10.1166/jbn.2012.1442 PMID:22888744
- Wang, L. N., Su, W. J., Liu, Z., Zhou, M. Q., Chen, S., Chen, Y. A., Lu, D., Liu, Y. H., Fan, Y., Zheng, Y. Z., Han, Z. C., Kong, D. L., et al. Cd44 antibody-targeted liposomal nanoparticles for molecular imaging and therapy of hepatocellular carcinoma Biomaterials 2012 33:5107-5114 DOI:10.1016/j.biomaterials.2012.03.067 PMID:22494888
- Lu, D., Chen, S., Tan, X. Y., Li, N., Liu, C. H., Li, Z. J., Liu, Z., Stupack, D. G., Reisfeld, R. A., Xiang, R. Fra-1 promotes breast cancer chemosensitivity by driving cancer stem cells from dormancy Cancer Research 2012 72:3451-3456 DOI:10.1158/0008-5472.can-11-2536 PMID:22586064
- Wang, L. N., Chen, S., Zhang, M. N., Li, N., Chen, Y. N., Su, W. J., Liu, Y. H., Lu, D., Li, S. L., Yang, Y. X., Li, Z. J., Stupack, D., et al. Legumain: A biomarker for diagnosis and prognosis of human ovarian cancer Journal of Cellular Biochemistry 2012 113:2679-2686 DOI:10.1002/jcb.24143 PMID:22441772
- Chen, S., Xu, Y. X., Chen, Y. A., Li, X. F., Mou, W. J., Wang, L. N., Liu, Y. H., Reisfeld, R. A., Xiang, R., Lv, D., Li, N. Sox2 gene regulates the transcriptional network of oncogenes and affects tumorigenesis of human lung cancer cells PLoS One 2012 7:e36326 DOI:10.1371/journal.pone.0036326 PMID:22615765 PMCID:PMC3352903
- Yang, X., Niu, G. L., Cao, X. F., Wen, Y. K., Xiang, R., Duan, H. Q., Chen, Y. S. The preparation of functionalized graphene oxide for targeted intracellular delivery of siRNA Journal of Materials Chemistry 2012 22:6649-6654 DOI:10.1039/c2jm14718a
- Zhang, C. Y., Bai, N., Zhang, Z. H., Liang, N., Dong, L., Xiang, R., Liu, C. H. Tlr2 signaling subpathways regulate tlr9 signaling for the effective induction of il-12 upon stimulation by heat-killed brucella abortus Cellular & Molecular Immunology 2012 9:324-333 DOI:10.1038/cmi.2012.11 PMID:22635254 PMCID:PMC4012865
- Su, W. J., Zhou, M. Q., Zheng, Y. Z., Fan, Y., Wang, L. N., Han, Z. C., Kong, D. L., Zhao, R. C., Wu, J. C., Xiang, R., Li, Z. J. Bioluminescence reporter gene imaging characterize human embryonic stem cell-derived teratoma formation Journal of Cellular Biochemistry 2011 112:840-848 DOI:10.1002/jcb.22982 PMID:21328457 PMCID:PMC3138474
- Zhao, L. Z., Xiang, R., Ma, R. J., Wang, X., An, Y. L., Shi, L. Q. Chiral conversion and memory of tpps j-aggregates in complex micelles: Peg-b-pdmaema/tpps Langmuir 2011 27:11554-11559 DOI:10.1021/la201434r PMID:21846100
- Hu, J. J., Qin, K. H., Zhang, Y., Gong, J. B., Li, N., Lv, D., Xiang, R., Tan, X. Y. Downregulation of transcription factor oct4 induces an epithelial-to-mesenchymal transition via enhancement of ca2+ influx in breast cancer cells Biochemical and Biophysical Research Communications 2011 411:786-791 DOI:10.1016/j.bbrc.2011.07.025 PMID:21798248
- Xu, C. F., Liu, J., Hsu, L. C., Luo, Y. P., Xiang, R., Chuang, T. H. Functional interaction of heat shock protein 90 and beclin 1 modulates toll-like receptor-mediated autophagy FASEB Journal 2011 25:2700-2710 DOI:10.1096/fj.10-167676 PMID:21543763 PMCID:PMC3136344
- Hao, J. W., Campagnolo, D., Liu, R. L., Piao, W. H., Shi, S., Hu, B. Y., Xiang, R., Zhou, Q. H., Vollmer, T., Van Kaer, L., La Cava, A., Shi, F. D. Interleukin-2/interleukin-2 antibody therapy induces target organ natural killer cells that inhibit central nervous system inflammation Annals of Neurology 2011 69:721-734 DOI:10.1002/ana.22339 PMID:21425186 PMCID:PMC3082615
- Zhao, L. Z., Xiang, R., Zhang, L. Y., Wu, C. L., Ma, R. J., An, Y. L., Shi, L. Q. Micellization of copolymers via noncovalent interaction with tpps and aggregation of tpps Science China-Chemistry 2011 54:343-350 DOI:10.1007/s11426-010-4202-x
- Jia, X. P., Li, X. F., Xu, Y. X., Zhang, S., Mou, W. J., Liu, Y. H., Liu, Y., Lv, D., Liu, C. H., Tan, X. Y., Xiang, R., Li, N. Sox2 promotes tumorigenesis and increases the anti-apoptotic property of human prostate cancer cell Journal of Molecular Cell Biology 2011 3:230-238 DOI:10.1093/jmcb/mjr002 PMID:21415100
- Liu, J., Xu, C. F., Hsu, L. C., Luo, Y. P., Xiang, R., Chuang, T. H. A five-amino-acid motif in the undefined region of the tlr8 ectodomain is required for species-specific ligand recognition Molecular Immunology 2010 47:1083-1090 DOI:10.1016/j.molimm.2009.11.003 PMID:20004021 PMCID:PMC2815190
- Hao, J. W., Liu, R. L., Piao, W. H., Zhou, Q. H., Vollmer, T. L., Campagnolo, D. I., Xiang, R., La Cava, A., Van Kaer, L., Shi, F. D. Central nervous system (cns)-resident natural killer cells suppress th17 responses and cns autoimmune pathology Journal of Experimental Medicine 2010 207:1907-1921 DOI:10.1084/jem.20092749 PMID:20696699 PMCID:PMC2931174
- Wang, Q. S., Ni, H., Lan, L., Wei, X. L., Xiang, R., Wang, Y. Fra-1 protooncogene regulates il-6 expression in macrophages and promotes the generation of m2d macrophages Cell Research 2010 20:701-712 DOI:10.1038/cr.2010.52 PMID:20386569
- Li, Y. J., Jiang, M., Liu, W., Zhang, L. H., Zhang, S., Zhao, X. P., Xiang, R., Liu, Y. Loop-mediated isothermal amplification method targets to the phop gene for detection of yersinia enterocolitica Molecular and Cellular Probes 2010 24:68-71 DOI:10.1016/j.mcp.2009.10.003 PMID:19833197
- Li, X. F., Zhang, S., Zhang, H. W., Zhang, L. H., Tao, H. T., Yu, J., Zheng, W. J., Liu, C. H., Lu, D., Xiang, R., Liu, Y. A loop-mediated isothermal amplification method targets the phop gene for the detection of salmonella in food samples International Journal of Food Microbiology 2009 133:252-258 DOI:10.1016/j.ijfoodmicro.2009.05.027 PMID:19540609
- Zhang, W. Y., Xu, F. Q., Shan, C. L., Xiang, R., Ye, L. H., Zhang, X. D. Gene expression profiles of human liver cells mediated by hepatitis b virus x protein Acta Pharmacologica Sinica 2009 30:424-434 DOI:10.1038/aps.2009.22 PMID:19343061 PMCID:PMC4002275
- Wei, X. L., Ni, H., Wang, Q. S., Xiang, R., Wang, Y. Impact of stat4 gene silencing on the expression profile of proteins in el-4 cells Chinese Science Bulletin 2009 54:3265-3270 DOI:10.1007/s11434-009-0468-9
- Lee, J., Hayashi, M., Lo, J. F., Fearns, C., Chu, W. M., Luo, Y. P., Xiang, R., Chuang, T. H. Nuclear factor kappa B (NF-kappa B) activation primes cells to a pro-inflammatory polarized response to a Toll-like receptor 7 (TLR7) agonist Biochemical Journal 2009 421:301-310 DOI:10.1042/bj20090013 PMID:19426145 PMCID:PMC2746977
- Tang, K. F., Xie, J., Chen, M., Liu, Q., Zhou, X. Y., Zeng, W., Huang, A. L., Zuo, G. Q., Wang, Y., Xiang, R., Ren, H. Knockdown of damage-specific DNA binding protein 1 (ddb1) enhances the hbx-sirna-mediated inhibition of hbv replication Biologicals 2008 36:177-183 DOI:10.1016/j.biologicals.2007.11.002 PMID:18289873
- Zeng, Y., Jiang, J., Huebener, N., Wenkel, J., Gaedicke, G., Xiang, R., Lode, H. N. Fractalkine gene therapy for neuroblastoma is more effective in combination with targeted il-2 Cancer Letters 2005 228:187-193 DOI:10.1016/j.canlet.2005.01.057 PMID:15953676