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Wu, Peng
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Wu, Peng

Faculty Member
Graduate Student
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Positions

  • 2018 - Associate Professor Tenure, Molecular Medicine , Scripps Research
  • 2015 - Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
  • 2017 - 2018 Associate Professor, Molecular Medicine , Scripps Research
  • 2015 - 2017 Associate Professor, Chemical Physiology , Scripps Research
  • 2014 - 2015 Visiting Investigator, Chemistry , Scripps Research
  • 2013 - 2014 Associate Professor, Albert Einstein College of Medicine
  • 2011 - 2014 Scientific Director of the Chemical Biology Core Facility, Albert Einstein College of Medicine
  • 2013 Visiting Fellow, Pembroke College , University of Oxford
  • 2008 - 2013 Assistant Professor, Albert Einstein College of Medicine
  • 2005 - 2008 Postdoctoral Associate, University of California, Berkeley

The research in the Wu Laboratory integrates synthetic chemistry with biochemistry to explore the relevance of glycosylation in human disease. The glycome, defined as the full complement of glycans that a cell produces, is involved in a variety of physiological processes, including angiogenesis, fertilization, stem cell development and neuronal development. Changes in the glycome have also been shown to mark the onset of cancer and inflammation. The wealth of biological information encoded in the glycome has motivated researchers to develop methods for its retrieval.

Produced by the secondary metabolism rather than encoded in the genome, glycans are assembled in a step-wise fashion by multiple enzymes and thus by multiple genes. Therefore, genetic and biochemical tools alone cannot be used to define all aspects of the glycome. Rather, many complementary approaches must be applied in parallel in order to assemble a picture of the glycome both from the “bottom up” and from the “top down”.

The major goal of our lab is to develop chemical biology platforms to image and characterize the glycome in the immune system and in tumors. We are also interested in chemical tools that can be used to selectively enrich glycoproteins for their molecular identification. These new tools will facilitate the discovery of new biomarkers for diseases, and assist in the development of clinical diagnostics and therapeutics.

Key biological questions we are interested include: How does cell-surface glycosylation change during immune-cell activation and what is the underlying mechanism? How do tumor cells exploit glycan-lectin interactions to suppress immune-cell activation within the tumor microenvironment? How to boost activities of leukocytes by using small-molecule probes to control cell-surface glycan mediated signaling?

Contact

  • pengwu@scripps.edu

Websites

  • Peng Wu, Ph.D.
  • Doctoral Dissertation
  • Laboratory Website
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Publications

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    • Zheng, Q., Xu, H. T., Wang, H., Du, W. G. H., Wang, N., Xiong, H., Gu, Y., Noodleman, L., Sharpless, K. B., Yang, G., Wu, P. Sulfur [ 18 F]Fluoride Exchange Click Chemistry Enabled Ultrafast Late-Stage Radiosynthesis Journal of the American Chemical Society  2021 143:3753-3763  DOI:10.1021/jacs.0c09306  PMID:33630577
    • Kim, H., Zhao, J. Y., Bae, J., Klivansky, L. M., Dailing, E. A., Liu, Y., Cappiello, J. R., Sharpless, K. B., Wu, P. Chain-Growth Sulfur(VI) Fluoride Exchange Polycondensation: Molecular Weight Control and Synthesis of Degradable Polysulfates ACS Central Science  2021 7:1919-1928  DOI:10.1021/acscentsci.1c01015  PMID:34841062  PMCID:PMC8614101
    • Hong, S. L., Yu, C. H., Wang, P., Shi, Y., Cao, W. Q., Cheng, B., Chapla, D. G., Ma, Y. H., Li, J., Rodrigues, E., Narimatsu, Y., Yates III, J. R., et al. Glycoengineering of NK Cells with Glycan Ligands of CD22 and Selectins for B-Cell Lymphoma Therapy Angewandte Chemie-International Edition  2020 60:3603-3610  DOI:10.1002/anie.202005934  PMID:33314603
    • Liu, Z., Li, J. P., Chen, M., Wu, M., Shi, Y., Li, W., Teijaro, J. R., Wu, P. Detecting Tumor Antigen-Specific T Cells via Interaction-Dependent Fucosyl-Biotinylation Cell  2020 183:1117-1133  DOI:10.1016/j.cell.2020.09.048  PMID:33096019  PMCID:PMC7669731
    • Hong, S. L., Feng, L., Yang, Y., Jiang, H., Hou, X. M., Guo, P., Marlow, F. L., Stanley, P., Wu, P. In Situ Fucosylation of the Wnt Co-receptor LRP6 Increases Its Endocytosis and Reduces Wnt/β-Catenin Signaling Cell Chemical Biology  2020 27:1140-1150  DOI:10.1016/j.chembiol.2020.06.015  PMID:32649905  PMCID:PMC7543979
    • Cao, Z. L., Zhou, F., Gu, P. Y., Chen, D. Y., He, J. H., Cappiello, J. R., Wu, P., Xu, Q. F., Lu, J. M. Preparation of aryl polysulfonates via a highly efficient SuFEx click reaction, their controllable degradation and functionalized behavior Polymer Chemistry  2020 11:3120-3124  DOI:10.1039/d0py00435a
    • Hong, S. L., Grande, G., Yu, C. H., Chapla, D. G., Reigh, N., Yang, J. Y., Yang, Y., Izumori, K., Moremen, K. W., Xie, J., Wu, P. hFUT1-Based Live-Cell Assay To Profile α1-2-Fucoside-Enhanced Influenza Virus A Infection ACS Chemical Biology  2020 15:819-823  DOI:10.1021/acschembio.9b00869  PMID:32271008
    • Hong, S., Sahai-Hernandez, P., Chapla, D. G., Moremen, K. W., Traver, D., Wu, P. Direct visualization of live zebrafish glycans via single-step metabolic labeling with fluorophore-tagged nucleotide sugars Angewandte Chemie-International Edition  2019  DOI:10.1002/anie.201907410  PMID:31295389
    • Liu, F., Wang, H., Li, S., Bare, G. A. L., Chen, X., Wang, C., Moses, J. E., Wu, P., Sharpless, K. B. Biocompatible SuFEx click chemistry: thionyl tetrafluoride (SOF4)-derived connective hubs for bioconjugation to DNA and proteins Angewandte Chemie-International Edition  2019 58:8029-8033  DOI:10.1002/anie.201902489  PMID:30998840  PMCID:PMC6546515
    • Liu, Y., Hu, H., Wang, J., Zhou, Q., Wu, P., Yan, N., Wang, H. W., Wu, J. W., Sun, L. Cryo-EM structure of L-fucokinase/GDP-fucose pyrophosphorylase (FKP) in Bacteroides fragilis Protein & Cell  2019 10:365-369  DOI:10.1007/s13238-018-0576-x  PMID:30242642  PMCID:PMC6468028
    • Tomita, T., Wang, H., Wu, P., Weiss, L. M. Stage-specific and selective delivery of caged azidosugars into the intracellular parasite Toxoplasma gondii by using an esterase-ester pair technique MSphere  2019 4:e00142-19  DOI:10.1128/mSphere.00142-19  PMID:31142619  PMCID:PMC6541734
    • Hong, S., Shi, Y., Wu, N. C., Grande, G., Douthit, L., Wang, H., Zhou, W., Sharpless, K. B., Wilson, I. A., Xie, J., Wu, P. Bacterial glycosyltransferase-mediated cell-surface chemoenzymatic glycan modification Nature Communications  2019 10  DOI:10.1038/s41467-019-09608-w  PMID:30996301  PMCID:PMC6470217
    • Li, J., Chen, M., Liu, Z., Zhang, L., Felding, B. H., Moremen, K. W., Lauvau, G., Abadier, M., Ley, K., Wu, P. A single-step chemoenzymatic reaction for the construction of antibody-cell conjugates ACS Central Science  2018 4:1633-1641  DOI:10.1021/acscentsci.8b00552  PMID:30648147  PMCID:PMC6311947
    • Zheng, T., Xie, J., Yang, Z., Tao, P., Shi, B., Douthit, L., Wu, P., Lerner, R. A. Antibody selection using clonal cocultivation of Escherichia coli and eukaryotic cells in miniecosystems Proceedings of the National Academy of Sciences of the United States of America  2018 115:E6145-E6151  DOI:10.1073/pnas.1806718115  PMID:29915075
    • Rouhanifard, S. H., Aguilar, A. L., Meng, L., Moremen, K. W., Wu, P. Engineered glycocalyx regulates stem cell proliferation in murine crypt organoids Cell Chemical Biology  2018 25:439-446  DOI:10.1016/j.chembiol.2018.01.010  PMID:29429899  PMCID:PMC5910180
    • Aguilar, A. L., Meng, L., Hou, X., Li, W., Moremen, K. W., Wu, P. Sialyltransferase-based chemoenzymatic histology for the detection of N- and O-glycans Bioconjugate Chemistry  2018 29:1231-1239  DOI:10.1021/acs.bioconjchem.8b00021  PMID:29569918
    • Briard, J. G., Jiang, H., Moremen, K. W., Macauley, M. S., Wu, P. Cell-based glycan arrays for probing glycan-glycan binding protein interactions Nature Communications  2018 9  DOI:10.1038/s41467-018-03245-5  PMID:29491407  PMCID:PMC5830402
    • Liu, Z., Li, J., Li, S., Li, G., Sharpless, K. B., Wu, P. SuFEx click chemistry enabled late-stage drug functionalization Journal of the American Chemical Society  2018 140:2919-2925  DOI:10.1021/jacs.7b12788  PMID:29451783
    • Jiang, H., Lopez-Aguilar, A., Meng, L., Gao, Z., Liu, Y., Tian, X., Yu, G., Ovryn, B., Moremen, K. W., Wu, P. Modulating cell-surface receptor signaling and ion channel functions by in situ glycan editing Angewandte Chemie International Edition  2018 57:967-971  DOI:10.1002/anie.201706535  PMID:29292859  PMCID:PMC5779621
    • Schneider, M., Kumar, V., Nordstrom, L. U., Feng, L., Takeuchi, H., Hao, H., Luca, V. C., Garcia, K. C., Stanley, P., Wu, P., Haltiwanger, R. S. Inhibition of Delta-induced Notch signaling using fucose analogs Nature Chemical Biology  2018 14:65-71  DOI:10.1038/nchembio.2520  PMID:29176671  PMCID:PMC5726916
    • Aguilar, A. L., Hou, X., Wen, L., Wang, P. G., Wu, P. A chemoenzymatic histology method for O-GlcNAc detection ChemBioChem  2017 18:2416-2421  DOI:10.1002/cbic.201700515  PMID:29044951
    • Aguilar, A. L., Gao, Y., Hou, X., Lauvau, G., Yates III, J. R., Wu, P. Profiling of protein O-GIcNAcylation in murine CD8(+) effector- and memory-like T cells ACS Chemical Biology  2017 12:3031-3038  DOI:10.1021/acschembio.7b00869  PMID:29125738
    • Gao, B., Zhang, L., Zheng, Q., Zhou, F., Klivansky, L. M., Lu, J., Liu, Y., Dong, J., Wu, P., Sharpless, K. B. Bifluoride-catalysed sulfur(VI) fluoride exchange reaction for the synthesis of polysulfates and polysulfonates Nature Chemistry  2017 9:1083-1088  DOI:10.1038/nchem.2796  PMID:29064495
    • Zhu, H., Chen, D., Li, N., Xu, Q., Li, H., He, J., Wang, H., Wu, P., Lu, J. Fabrication of photocontrolled surfaces for oil/water separation through sulfur(VI) fluoride exchange Chemistry-a European Journal  2017 23:14712-14717  DOI:10.1002/chem.201703309  PMID:28881405
    • Hamadani, K. M., Howe, J., Jensen, M. K., Wu, P., Cate, J. H. D., Marqusee, S. An in vitro tag-and-modify protein sample generation method for single-molecule fluorescence resonance energy transfer Journal of Biological Chemistry  2017 292:15636-15648  DOI:10.1074/jbc.M117.791723  PMID:28754692  PMCID:PMC5612098
    • Wang, H., Zhou, F., Ren, G., Zheng, Q., Chen, H., Gao, B., Klivansky, L., Liu, Y., Wu, B., Xu, Q., Lu, J., Sharpless, K. B., et al. SuFEx-based polysulfonate formation from ethenesulfonyl fluoride-amine adducts Angewandte Chemie-International Edition  2017 56:11203-11208  DOI:10.1002/anie.201701160  PMID:28792119
    • Ovryn, B., Li, J., Hong, S., Wu, P. Visualizing glycans on single cells and tissues-Visualizing glycans on single cells and tissues Current Opinion in Chemical Biology  2017 39:39-45  DOI:10.1016/j.cbpa.2017.04.018  PMID:28578260
    • Zha, G. F., Zheng, Q., Leng, J., Wu, P., Qin, H. L., Sharpless, K. B. Palladium-catalyzed fluorosulfonylvinylation of organic iodides Angewandte Chemie-International Edition  2017 56:4849-4852  DOI:10.1002/anie.201701162  PMID:28370917
    • Lopez Aguilar, A., Briard, J. G., Yang, L., Ovryn, B., Macauley, M. S., Wu, P. Tools for studying glycans: Recent advances in chemoenzymatic glycan labeling ACS Chemical Biology  2017 12:611-621  DOI:10.1021/acschembio.6b01089  PMID:28301937
    • Qin, H. L., Zheng, Q., Bare, G. A. L., Wu, P., Sharpless, K. B. A Heck-Matsuda process for the synthesis of β-arylethenesulfonyl fluorides: selectively addressable bis-electrophiles for SuFEx click chemistry Angewandte Chemie-International Edition  2016 55:14155-14158  DOI:10.1002/anie.201608807  PMID:27723200  PMCID:PMC5102157
    • Boons, G. J., Wu, P. Chemical Glycobiology Introduction Glycobiology  2016 26:788-788  DOI:10.1093/glycob/cww072  PMID:27496763
    • Cook, I., Wang, T., Wang, W., Kopp, F., Wu, P., Leyh, T. S. Controlling sulfuryl-transfer biology Cell Chemical Biology  2016 23:579-586  DOI:10.1016/j.chembiol.2016.04.009  PMID:27203377  PMCID:PMC4898890
    • Zhang, E., Tang, J., Li, S., Wu, P., Moses, J. E., Sharpless, K. B. Chemoselective synthesis of polysubstituted pyridines from heteroaryl fluorosulfates Chemistry-a European Journal  2016 22:5692-5697  DOI:10.1002/chem.201600167  PMID:26990693  PMCID:PMC4929982
    • Chen, W., Dong, J., Li, S., Wang, Y., Yoon, L., Wu, P., Sharpless, K. B., Kelly, J. W. Synthesis of sulfotyrosine-containing peptides by incorporating fluorosulfated tyrosine using an Fmoc-based solid-phase strategy Angewandte Chemie-International Edition  2016 55:1835-1838  DOI:10.1002/anie.201509016  PMID:26696445  PMCID:PMC4928576
    • Jiang, H., English, B. P., Hazan, R. B., Wu, P., Ovryn, B. Tracking surface glycans on live cancer cells with single-molecule sensitivity Angewandte Chemie-International Edition  2015 54:1765-1769  DOI:10.1002/anie.201407976  PMID:25515330  PMCID:PMC4465920
    • Rouhanifard, S. H., Lopez-Aguilar, A., Wu, P. CHoMP: a chemoenzymatic histology method using clickable probes ChemBioChem  2014 15:2667-2673  DOI:10.1002/cbic.201402433  PMID:25403986  PMCID:PMC4278937
    • Feng, L., Jiang, H., Wu, P., Marlow, F. L. Negative feedback regulation of Wnt signaling via N-linked fucosylation in zebrafish Developmental Biology  2014 395:268-286  DOI:10.1016/j.ydbio.2014.09.010  PMID:25238963  PMCID:PMC4259045
    • Yang, M., Jalloh, A. S., Wei, W., Zhao, J., Wu, P., Chen, P. R. Biocompatible click chemistry enabled compartment-specific pH measurement inside E-coli Nature Communications  2014 5:4981  DOI:10.1038/ncomms5981  PMID:25236616  PMCID:PMC4174402
    • Jiang, H., Zheng, T., Lopez-Aguilar, A., Feng, L., Kopp, F., Marlow, F. L., Wu, P. Monitoring dynamic glycosylation in vivo using supersensitive click chemistry Bioconjugate Chemistry  2014 25:698-706  DOI:10.1021/bc400502d  PMID:24499412  PMCID:PMC3993875
    • Bertozzi, C. R., Wu, P. In vivo chemistry Current Opinion in Chemical Biology  2013 17:717-718  DOI:10.1016/j.cbpa.2013.10.012  PMID:24156981
    • Zheng, T., Jiang, H., Wu, P. Single-stranded DNA as a cleavable linker for bioorthogonal click chemistry-based proteomics Bioconjugate Chemistry  2013 24:859-864  DOI:10.1021/bc400093x  PMID:23627610  PMCID:PMC4078914
    • Rouhanifard, S. H., Nordstrom, L. U., Zheng, T., Wu, P. Chemical probing of glycans in cells and organisms Chemical Society Reviews  2013 42:4284-4296  DOI:10.1039/c2cs35416k  PMID:23257905  PMCID:PMC3641795
    • Rouhanifard, S. H., Xie, R., Zhang, G., Sun, X., Chen, X., Wu, P. Detection and isolation of dendritic cells using Lewis X-functionalized magnetic nanoparticles Biomacromolecules  2012 13:3039-3045  DOI:10.1021/bm3007506  PMID:22901307  PMCID:PMC3470862
    • Lakshmanan, V., Rhee, K. Y., Wang, W., Yu, Y., Khafizov, K., Fiser, A., Wu, P., Ndir, O., Mboup, S., Ndiaye, D., Daily, J. P. Metabolomic analysis of patient plasma yields evidence of plant-like α-linolenic acid metabolism in Plasmodium falciparum Journal of Infectious Diseases  2012 206:238-248  DOI:10.1093/infdis/jis339  PMID:22566569  PMCID:PMC3490690
    • Zheng, T., Rouhanifard, S. H., Jalloh, A. S., Wu, P. Click triazoles for bioconjugation Topics in Heterocyclic Chemistry  2012 28:163-183  DOI:10.1007/7081_2011_72  PMID:25431628  PMCID:PMC4243930
    • Li, B., Mock, F., Wu, P. Imaging the glycome in living systems Methods in Enzymology  2012 401-419  DOI:10.1016/b978-0-12-388448-0.00029-2  PMID:22289465  PMCID:PMC5014494
    • Wang, W., Hong, S., Andrew, T., Jiang, H., Triano, R., Liu, Y., Chen, X., Wu, P. Sulfated ligands for the copper(I)-catalyzed azide-alkyne cycloaddition Chemistry-an Asian Journal  2011 6:2796-2802  DOI:10.1002/asia.201100385  PMID:21905231  PMCID:PMC3568503
    • Besanceney-Webler, C., Jiang, H., Wang, W., Baughn, A. D., Wu, P. Metabolic labeling of fucosylated glycoproteins in Bacteroidales species Bioorganic & Medicinal Chemistry Letters  2011 21:4989-4992  DOI:10.1016/j.bmcl.2011.05.038  PMID:21676614  PMCID:PMC3156311
    • Jiang, H., Feng, L., Soriano del Amo, D., Seidel III, R. D., Marlow, F. L., Wu, P. Imaging glycans in zebrafish embryos by metabolic labeling and bioorthogonal click chemistry Journal of Visualized Experiments : JoVE  2011 pii: 2686  DOI:10.3791/2686  PMID:21673647  PMCID:PMC3197039
    • Dehnert, K. W., Beahm, B. J., Huynh, T. T., Baskin, J. M., Laughlin, S. T., Wang, W., Wu, P., Amacher, S. L., Bertozzi, C. R. Metabolic labeling of fucosylated glycans in developing zebrafish ACS Chemical Biology  2011 6:547-552  DOI:10.1021/cb100284d  PMID:21425872  PMCID:PMC3117394
    • Besanceney-Webler, C., Jiang, H., Zheng, T., Feng, L., Soriano del Amo, D., Wang, W., Klivansky, Liana M., Marlow, F. L., Liu, Y., Wu, P. Increasing the efficacy of bioorthogonal click reactions for bioconjugation: a comparative study Angewandte Chemie-International Edition  2011 50:8051-8056  DOI:10.1002/anie.201101817  PMID:21761519  PMCID:PMC3465470
    • Zheng, T., Jiang, H., Gros, M., Soriano del Amo, D., Sundaram, S., Lauvau, G., Marlow, F. L., Liu, Y., Stanley, P., Wu, P. Tracking N-acetyllactosamine on cell-surface glycans in vivo Angewandte Chemie-International Edition  2011 50:4113-4118  DOI:10.1002/anie.201100265  PMID:21472942  PMCID:PMC3136350
    • Yap, M. C., Kostiuk, M. A., Martin, Dale D. O., Perinpanayagam, M. A., Hak, P. G., Siddam, A., Majjigapu, J. R., Rajaiah, G., Keller, B. O., Prescher, J. A., Wu, P., Bertozzi, C. R., et al. Rapid and selective detection of fatty acylated proteins using omega-alkynyl-fatty acids and click chemistry Journal of Lipid Research  2010 51:1566-1580  DOI:10.1194/jlr.D002790  PMID:20028662  PMCID:PMC3035521
    • Breidenbach, M. A., Gallagher, J. E. G., King, D. S., Smart, B. P., Wu, P., Bertozzi, C. R. Targeted metabolic labeling of yeast N-glycans with unnatural sugars Proceedings of the National Academy of Sciences of the United States of America  2010 107:3988-3993  DOI:10.1073/pnas.0911247107  PMID:20142501  PMCID:PMC2840165
    • Soriano Del Amo, D., Wang, W., Jiang, H., Besanceney, C., Yan, A. C., Levy, M., Liu, Y., Marlow, F. L., Wu, P. Biocompatible copper(I) catalysts for in vivo imaging of glycans Journal of the American Chemical Society  2010 132:16893-16899  DOI:10.1021/ja106553e  PMID:21062072  PMCID:PMC3021957
    • Soriano del Amo, D., Wang, W., Besanceney, C., Zheng, T., He, Y., Gerwe, B., Seidel III, R. D., Wu, P. Chemoenzymatic synthesis of the sialyl Lewis X glycan and its derivatives Carbohydrate Research  2010 345:1107-13  DOI:10.1016/j.carres.2010.03.032  PMID:20435300  PMCID:PMC2945603
    • Wang, W., Hu, T., Frantom, P. A., Zheng, T., Gerwe, B., Soriano del Amo, D., Garret, S., Seidel III, R. D., Wu, P. Chemoenzymatic synthesis of GDP-L-fucose and the Lewis X glycan derivatives Proceedings of the National Academy of Sciences of the United States of America  2009 106:16096-16101  DOI:10.1073/pnas.0908248106  PMID:19805264  PMCID:PMC2752511
    • Perrine, C. L., Ganguli, A., Wu, P., Bertozzi, C. R., Fritz, T. A., Raman, J., Tabak, L. A., Gerken, T. A. Glycopeptide-preferring polypeptide GalNAc transferase 10 (ppGalNAc T10), involved in mucin-type O-glycosylation, has a unique GalNAc-O-Ser/Thr-binding site in its catalytic domain not found in ppGalNAc T1 or T2 Journal of Biological Chemistry  2009 284:20387-20397  DOI:10.1074/jbc.M109.017236  PMID:19460755  PMCID:PMC2740463
    • Wu, P., Shui, W., Carlson, B. L., Hu, N., Rabuka, D., Lee, J., Bertozzi, C. R. Site-specific chemical modification of recombinant proteins produced in mammalian cells by using the genetically encoded aldehyde tag Proceedings of the National Academy of Sciences of the United States of America  2009 106:3000-3005  DOI:10.1073/pnas.0807820106  PMID:19202059  PMCID:PMC2651276
    • Chen, X., Wu, P., Rousseas, M., Okawa, D., Gartner, Z., Zettl, A., Bertozzi, C. R. Boron nitride nanotubes are noncytotoxic and can be functionalized for interaction with proteins and cells Journal of the American Chemical Society  2009 131:890-891  DOI:10.1021/ja807334b  PMID:19119844  PMCID:PMC2657038
    • Chang, P. V., Chen, X., Smyrniotis, C., Xenakis, A., Hu, T., Bertozzi, C. R., Wu, P. Metabolic labeling of sialic acids in living animals with alkynyl sugars Angewandte Chemie-International Edition  2009 48:4030-4033  DOI:10.1002/anie.200806319  PMID:19388017  PMCID:PMC2868584
    • Wu, P., Chen, X., Hu, N., Tam, U. C., Blixt, O., Zettl, A., Bertozzi, C. R. Biocompatible carbon nanotubes generated by functionalization with glycodendrimers Angewandte Chemie-International Edition  2008 47:5022-5025  DOI:10.1002/anie.200705363  PMID:18509843  PMCID:PMC2847391
    • degree-related publication Vestberg, R., Malkoch, M., Kade, M., Wu, P., Fokin, V. V., Sharpless, K. B., Drockenmuller, E., Hawker, C. J. Role of architecture and molecular weight in the formation of tailor-made ultrathin multilayers using dendritic macromolecules and click chemistry Journal of Polymer Science Part A-Polymer Chemistry  2007 45:2835-2846  DOI:10.1002/pola.22178
    • Rinaldo-Matthis, A., Wing, C., Ghanem, M., Deng, H., Wu, P., Gupta, A., Tyler, P. C., Evans, G. B., Furneaux, R. H., Almo, S. C., Wang, C. C., Schramm, V. L. Inhibition and structure of Trichomonas vaginalis purine nucleoside phosphorylase with picomolar transition state analogues Biochemistry  2007 46:659-668  DOI:10.1021/bi061515r  PMID:17223688  PMCID:PMC2517847
    • degree-related publication Wu, P., Fokin, V. V. Catalytic azide-alkyne cycloaddition: reactivity and applications Aldrichimica Acta  2007 40:7-17
    • degree-related publication Wu, P., Hilgraf, R., Fokin, V. V. Osmium-catalyzed olefin dihydroxylation and aminohydroxylation in the second catalytic cycle Advanced Synthesis & Catalysis  2006 348:1079-1085  DOI:10.1002/adsc.200505252
    • degree-related publication Fokin, V. V., Wu, P. Epoxides and aziridines in click chemistry Aziridines and Epoxides in Organic Synthesis  2006 443-477  DOI:10.1002/3527607862.ch12
    • degree-related publication Sharpless, W. D., Wu, P., Hansen, T. V., Lindberg, J. G. Just click it: Undergraduate procedures for the copper(I)-catalyzed formation of 1,2,3-triazoles from azides and terminal acetylenes Journal of Chemical Education  2005 82:1833-1836
    • degree-related publication Hansen, T. V., Wu, P., Fokin, V. V. One-pot copper(I)-catalyzed synthesis of 3,5-disubstituted isoxazoles Journal of Organic Chemistry  2005 70:7761-7764  DOI:10.1021/jo050163b  PMID:16149810
    • degree-related publication Malkoch, M., Schleicher, K., Drockenmuller, E., Hawker, C. J., Russell, T. P., Wu, P., Fokin, V. V. Structurally diverse dendritic libraries: a highly efficient functionalization approach using click chemistry Macromolecules  2005 38:3663-3678  DOI:10.1021/ma047657f
    • degree-related publication Wu, P., Malkoch, M., Hunt, J. N., Vestberg, R., Kaltgrad, E., Finn, M. G., Fokin, V. V., Sharpless, K. B., Hawker, C. J. Multivalent, bifunctional dendrimers prepared by click chemistry Chemical Communications  2005 5775-5777  DOI:10.1039/b512021g  PMID:16307142
    • Ferrando-Miguel, G., Wu, P., Huffman, J. C., Caulton, K. G. New d(4) dihydrides of Ru(IV) and Os(IV) with pi-donor ligands: M(H)(2)(chelate)((PPr3)-Pr-i)(2) with chelate = ortho-XYC6H4 with X, Y = O, NR; R = H or CH3 New Journal of Chemistry  2005 29:193-204  DOI:10.1039/b411487f
    • degree-related publication Wu, P., Feldman, A. K., Nugent, A. K., Hawker, C. J., Scheel, A., Voit, B., Pyun, J., Frechet, J. M. J., Sharpless, K. B., Fokin, V. V. Efficiency and fidelity in a click-chemistry route to triazole dendrimers by the copper(I)-catalyzed ligation of azides and alkynes Angewandte Chemie-International Edition  2004 43:3928-3932  DOI:10.1002/anie.200454078  PMID:15274216
    • Vedernikov, A. N., Wu, P., Huffman, J. C., Caulton, K. G. Cu(I) and Cu(II) complexes of a pyridine-based pincer ligand Inorganica Chimica Acta  2002 330:103-110  DOI:10.1016/s0020-1693(01)00825-8
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Teaching

advisees

  • graduate advising relationship

    • Yang, Zhuo, Ph.D.  candidate, 2019 -
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Background

education and training

  • Ph.D. in Chemistry, Scripps Research 2001 - 2005
  • M.S. in Chemistry, Indiana University 1999 - 2001
  • B.S. in Chemistry, Peking University 1995 - 1999

awards and honors

  • Kavli Fellow, conferred by US National Academy of Sciences and The Kavli Foundation, 2014
  • David Y. Gin Young Investigator Award, conferred by Division of Carbohydrate Chemistry, American Chemical Society, 2013
  • DuPont Young Professor Award, 2011 - 2014
  • NIH Pathway to Independence Award, conferred by National Institutes of Health, 2007 - 2012
  • Distinguished Faculty Award, conferred by Chinese-American Chemistry and Chemical Biology Professors Association Biomatik

advisee of

  • graduate advising relationship

    • Sharpless, K. Barry, Ph.D.  candidacy, 2002 - 2005
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Contact

full name

  • Peng Wu

geographic location

  • Scripps California 

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