Wong, Chi-Huey

recent publications

All Publications

PubMed Display for Export

Publications without PubMed PMIDs

academic article
- Liao, H. Y., Wang, S. C., Ko, Y. A., Lin, K. I., Ma, C., Cheng, T. J. R., Wong, C. H. Chimeric hemagglutinin vaccine elicits broadly protective CD4 and CD8 T cell responses against multiple influenza strains and subtypes Proceedings of the National Academy of Sciences of the United States of America 2020 117:17757-17763 DOI:10.1073/pnas.2004783117 PMID:32669430 PMCID:PMC7395492
- Dey, S., Lo, H. J., Wong, C. H. Programmable One-Pot Synthesis of Heparin Pentasaccharide Fondaparinux Organic Letters 2020 22:4638-4642 DOI:10.1021/acs.orglett.0c01386 PMID:32496799 PMCID:PMC7347301
- Chiu, L. T., Sabbavarapu, N. M., Lin, W. C., Fan, C. Y., Wu, C. C., Cheng, T. J. R., Wong, C. H., Hung, S. C. Trisaccharide Sulfate and Its Sulfonamide as an Effective Substrate and Inhibitor of Human Endo-O-sulfatase-1 Journal of the American Chemical Society 2020 142:5282-5292 DOI:10.1021/jacs.0c00005 PMID:32083852
- Woodring, J. L., Lu, S. H., Krasnova, L., Wang, S. C., Chen, J. B., Chou, C. C., Huang, Y. C., Cheng, T. J. R., Wu, Y. T., Chen, Y. H., Fang, J. M., Tsai, M. D., et al. Disrupting the conserved salt bridge in the trimerization of influenza A nucleoprotein Journal of Medicinal Chemistry 2020 63:205-215 DOI:10.1021/acs.jmedchem.9b01244 PMID:31769665
- Wang, E. A., Chen, W. Y., Wong, C. H. Multiple Growth Factor Targeting by Engineered Insulin-like Growth Factor Binding Protein-3 Augments EGF Receptor Tyrosine Kinase Inhibitor Efficacy Scientific Reports 2020 10 DOI:10.1038/s41598-020-59466-6 PMID:32066763 PMCID:PMC7026407
- Cheng, C. W., Wu, C. Y., Hsu, W. L., Wong, C. H. Programmable One-Pot Synthesis of Oligosaccharides Biochemistry 2020 59:3078-3088 DOI:10.1021/acs.biochem.9b00613 PMID:31454239
- Pawar, S., Hsu, L., Reddy, T. N., Ravinder, M., Ren, C. T., Lin, Y. W., Cheng, Y. Y., Lin, T. W., Hsu, T. L., Wang, S. K., Wong, C. H., Wu, C. Y. Synthesis of Asymmetric N-Glycans as Common Core Substrates for Structural Diversification through Selective Enzymatic Glycosylation ACS Chemical Biology 2020 15:2382-2394 DOI:10.1021/acschembio.00359 PMID:32830946
- Cheng, C. W., Zhou, Y., Pan, W. H., Dey, S., Wu, C. Y., Hsu, W. L., Wong, C. H. Hierarchical and programmable one-pot oligosaccharide synthesis Journal of Visualized Experiments : JoVE 2019 DOI:10.3791/59987 PMID:31545316
- Dey, S., Lo, H. J., Wong, C. H. An efficient modular one-pot synthesis of heparin-based anticoagulant idraparinux Journal of the American Chemical Society 2019 141:10309-10314 DOI:10.1021/jacs.9b03266 PMID:31244187
- Lo, H. J., Krasnova, L., Dey, S., Cheng, T., Liu, H., Tsai, T. I., Wu, K. B., Wu, C. Y., Wong, C. H. Synthesis of sialidase-resistant oligosaccharide and antibody glycoform containing α2,6-linked 3Fax-Neu5Ac Journal of the American Chemical Society 2019 141:6484-6488 DOI:10.1021/jacs.9b01991 PMID:30969765
- Krasnova, L., Wong, C. H. Oligosaccharide synthesis and translational innovation Journal of the American Chemical Society 2019 141:3735-3754 DOI:10.1021/jacs.8b11005 PMID:30716271
- Wong, C. H., Krasnova, L. Highlights in chemical glycobiology Israel Journal of Chemistry 2019 59:18-22 DOI:10.1002/ijch.201800139
- Cheng, C. W., Zhou, Y., Pan, W. H., Dey, S., Wu, C. Y., Hsu, W. L., Wong, C. H. Hierarchical and programmable one-pot synthesis of oligosaccharides Nature Communications 2018 9 DOI:10.1038/s41467-018-07618-8 PMID:30523255 PMCID:PMC6283847
- Wang, X., Krasnova, L., Wu, K. B., Wu, W. S., Cheng, T. J., Wong, C. H. Towards new antibiotics targeting bacterial transglycosylase: Synthesis of a Lipid II analog as stable transition-state mimic inhibitor Bioorganic & Medicinal Chemistry Letters 2018 28:2708-2712 DOI:10.1016/j.bmcl.2018.03.035 PMID:29602680
- Dey, S., Wong, C. H. Programmable one-pot synthesis of heparin pentasaccharides enabling access to regiodefined sulfate derivatives Chemical Science 2018 9:6685-6691 DOI:10.1039/c8sc01743c
- Shivatare, S. S., Huang, L. Y., Zeng, Y. F., Liao, J. Y., You, T. H., Wang, S. Y., Cheng, T., Chiu, C. W., Chao, P., Chen, L. T., Tsai, T. I., Huang, C. C., et al. Development of glycosynthases with broad glycan specificity for the efficient glyco-remodeling of antibodies Chemical Communications 2018 54:6161-6164 DOI:10.1039/c8cc03384f PMID:29809215
- Shivatare, V. S., Shivatare, S. S., Lee, C. C. D., Liang, C. H., Liao, K. S., Cheng, Y. Y., Saidachary, G., Wu, C. Y., Lin, N. H., Kwong, P. D., Burton, D. R., Wu, C. Y., et al. Unprecedented role of hybrid N-glycans as ligands for HIV-1 broadly neutralizing antibodies Journal of the American Chemical Society 2018 140:5202-5210 DOI:10.1021/jacs.8b00896 PMID:29578688
- Zhou, T., Zheng, A., Baxa, U., Chuang, G. Y., Georgiev, I. S., Kong, R., O'Dell, S., Shahzad-Ul-Hussan, S., Shen, C. H., Tsybovsky, Y., Bailer, R. T., Gift, S. K., et al. A neutralizing antibody recognizing primarily N-linked glycan targets the silent face of the HIV envelope Immunity 2018 48:500-513 DOI:10.1016/j.immuni.2018.02.013 PMID:29548671
- Liu, C. P., Tsai, T. I., Cheng, T., Shivatare, V. S., Wu, C. Y., Wu, C. Y., Wong, C. H. Glycoengineering of antibody (Herceptin) through yeast expression and in vitro enzymatic glycosylation Proceedings of the National Academy of Sciences of the United States of America 2018 115:720-725 DOI:10.1073/pnas.1718172115 PMID:29311294 PMCID:PMC5789950
- Huang, Y. W., Yang, H. I., Wu, Y. T., Hsu, T. L., Lin, T. W., Kelly, J. W., Wong, C. H. Residues comprising the enhanced aromatic sequon influence protein N-glycosylation efficiency Journal of the American Chemical Society 2017 139:12947-12955 DOI:10.1021/jacs.7b03868 PMID:28820257
- Shie, J. J., Liu, Y. C., Hsiao, J. C., Fang, J. M., Wong, C. H. A cell-permeable and triazole-forming fluorescent probe for glycoconjugate imaging in live cells Chemical Communications 2017 53:1490-1493 DOI:10.1039/c6cc08805h PMID:28084480
- Andrabi, R., Su, C. Y., Liang, C. H., Shivatare, S. S., Briney, B., Voss, J. E., Nawazi, S. K., Wu, C. Y., Wong, C. H., Burton, D. R. Glycans function as anchors for antibodies and help drive HIV broadly neutralizing antibody development Immunity 2017 47:524-537 DOI:10.1016/j.immuni.2017.08.006 PMID:28916265 PMCID:PMC5613947
- Tsai, T. I., Li, S. T., Liu, C. P., Chen, K. Y., Shivatare, S. S., Lin, C. W., Liao, S. F., Lin, C. W., Hsu, T. L., Wu, Y. T., Tsai, M. H., Lai, M. Y., et al. An effective bacterial fucosidase for glycoprotein remodeling ACS Chemical Biology 2017 12:63-72 DOI:10.1021/acschembio.6b00821 PMID:28103685
- Wu, T. N., Lin, K. H., Wu, Y. T., Huang, J. R., Hung, J. T., Wu, J. C., Chen, C. Y., Chu, K. C., Lin, N. H., Yu, A. L., Wong, C. H. Phenyl glycolipids with different glycosyl groups exhibit marked differences in murine and human iNKT cell activation ACS Chemical Biology 2016 11:3431-3441 DOI:10.1021/acschembio.6b00650 PMID:27782396
- Krasnova, L., Wong, C. H. Exploring human glycosylation for better therapies Molecular Aspects of Medicine 2016 51:125-143 DOI:10.1016/j.mam.2016.05.003 PMID:27178988
- Sok, D., Pauthner, M., Briney, B., Lee, J. H., Saye-Francisco, K. L., Hsueh, J., Ramos, A., Le, K. M., Jones, M., Jardine, J. G., Bastidas, R., Sarkar, A., et al. A prominent site of antibody vulnerability on HIV envelope incorporates a motif associated with CCR5 binding and its camouflaging glycans Immunity 2016 45:31-45 DOI:10.1016/j.immuni.2016.06.026 PMID:27438765 PMCID:PMC4990068
- Hsu, C. H., Park, S., Mortenson, D. E., Foley, B. L., Wang, X., Woods, R. J., Case, D. A., Powers, E. T., Wong, C. H., Dyson, H. J., Kelly, J. W. The dependence of carbohydrate-aromatic interaction strengths on the structure of the carbohydrate Journal of the American Chemical Society 2016 138:7636-7648 DOI:10.1021/jacs.6b02879 PMID:27249581 PMCID:PMC4924591
- Stewart-Jones, G. B. E., Soto, C., Lemmin, T., Chuang, G. Y., Druz, A., Kong, R., Thomas, P. V., Wagh, K., Zhou, T., Behrens, A. J., Bylund, T., Choi, C. W., et al. Trimeric HIV-1-Env structures define glycan shields from clades A, B, and G Cell 2016 165:813-826 DOI:10.1016/j.cell.2016.04.010 PMID:27114034
- Shivatare, S. S., Chang, S. H., Tsai, T. I., Tseng, S. Y., Shivatare, V. S., Lin, Y. S., Cheng, Y. Y., Ren, C. T., Lee, C. C. D., Pawar, S., Tsai, C. S., Shih, H. W., et al. Modular synthesis of N-glycans and arrays for the hetero-ligand binding analysis of HIV antibodies Nature Chemistry 2016 8:338-346 DOI:10.1038/nchem.2463 PMID:27001729 PMCID:PMC4806563
- Krasnova, L., Wong, C. H. Understanding the chemistry and biology of glycosylation with glycan synthesis Annual Review of Biochemistry 2016 85:599-630 DOI:10.1146/annurev-biochem-060614-034420 PMID:27145845
- Li, X., Kawamura, A., Andrews, C. D., Miller, J. L., Wu, D., Tsao, T., Zhang, M., Oren, D., Padte, N. N., Porcelli, S. A., Wong, C. H., Kappe, S. H. I., et al. Colocalization of a CD1d-binding glycolipid with a radiation-attenuated sporozoite vaccine in lymph node-resident dendritic cells for a robust adjuvant effect Journal of Immunology 2015 195:2710-2721 DOI:10.4049/jimmunol.1403017 PMID:26254338 PMCID:PMC4561196
- Danishefsky, S. J., Shue, Y. K., Chang, M. N., Wong, C. H. Development of globo-h cancer vaccine Accounts of Chemical Research 2015 48:643-652 DOI:10.1021/ar5004187 PMID:25665650
- Hsu, C. H., Schelwies, M., Enck, S., Huang, L. Y., Huang, S. H., Chang, Y. F., Cheng, T. J. R., Cheng, W. C., Wong, C. H. Iminosugar C-glycoside analogues of alpha-D-GlcNAc-1-Phosphate: synthesis and bacterial transglycosylase inhibition Journal of Organic Chemistry 2014 79:8629-8637 DOI:10.1021/jo501340s PMID:25137529 PMCID:PMC4168788
- Falkowska, E., Le, K. M., Ramos, A., Doores, K. J., Lee, J. H., Blattner, C., Ramirez, A., Derking, R., van Gils, M. J., Liang, C. H., McBride, R., von Bredow, B., et al. Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the prefusion conformation of gp41 on cleaved envelope trimers Immunity 2014 40:657-668 DOI:10.1016/j.immuni.2014.04.009 PMID:24768347 PMCID:PMC4070425
- Lin, J., Chang, Y., Yang, W. B., Yu, A. L., Wong, C. H. The multifaceted effects of polysaccharides isolated from Dendrobium huoshanense on immune functions with the induction of interleukin-1 receptor antagonist (IL-1ra) in monocytes PLoS One 2014 9:e94040 DOI:10.1371/journal.pone.0094040 PMID:24705413 PMCID:PMC3976396
- Padte, N. N., Boente-Carrera, M., Andrews, C. D., McManus, J., Grasperge, B. F., Gettie, A., Coelho-dos-Reis, J. G., Li, X., Wu, D., Bruder, J. T., Sedegah, M., Patterson, N., et al. A glycolipid adjuvant, 7DW8-5, enhances CD8+T cell responses induced by an adenovirus-vectored malaria vaccine in non-human primates PLoS One 2013 8:e78407 DOI:10.1371/journal.pone.0078407 PMID:24205224 PMCID:PMC3808339
- Liao, S. F., Liang, C. H., Ho, M. Y., Hsu, T. L., Tsai, T. I., Hsieh, Y. S., Tsai, C. M., Li, S. T., Cheng, Y. Y., Tsao, S. M., Lin, T. Y., Lin, Z. Y., et al. Immunization of fucose-containing polysaccharides from Reishi mushroom induces antibodies to tumor-associated Globo H-series epitopes Proceedings of the National Academy of Sciences of the United States of America 2013 110:13809-14 DOI:10.1073/pnas.1312457110 PMID:23908400 PMCID:PMC3752246
- Chen, W., Enck, S., Price, J. L., Powers, D. L., Powers, E. T., Wong, C. H., Dyson, H. J., Kelly, J. W. Structural and energetic basis of carbohydrate-aromatic packing interactions in proteins Journal of the American Chemical Society 2013 135:9877-9884 DOI:10.1021/ja4040472 PMID:23742246 PMCID:PMC3715148
- Huang, H. W., Chen, C. H., Lin, C. H., Wong, C. H., Lin, K. I. B-cell maturation antigen is modified by a single N-glycan chain that modulates ligand binding and surface retention Proceedings of the National Academy of Sciences of the United States of America 2013 110:10928-33 DOI:10.1073/pnas.1309417110 PMID:23776238 PMCID:PMC3704023
- Doores, K. J., Huber, M., Le, K. M., Wang, S. K., Doyle-Cooper, C., Cooper, A., Pantophlet, R., Wong, C. H., Nemazee, D., Burton, D. R. 2G12-expressing B cell lines may aid in HIV carbohydrate vaccine design strategies Journal of Virology 2013 87:2234-2241 DOI:10.1128/jvi.02820-12 PMID:23221565 PMCID:PMC3571453
- Al-Shareffi, E., Chaubard, J. L., Leonhard-Melief, C., Wang, S. K., Wong, C. H., Haltiwanger, R. S. 6-alkynyl fucose is a bioorthogonal analog for O-fucosylation of epidermal growth factor-like repeats and thrombospondin Type-1 repeats by protein O-fucosyltransferases 1 and 2 Glycobiology 2013 23:188-198 DOI:10.1093/glycob/cws140 PMID:23045360 PMCID:PMC3531295
- Cheng, T. J. R., Weinheimer, S., Tarbet, E. B., Jan, J. T., Cheng, Y. S. E., Shie, J. J., Chen, C. L., Chen, C. A., Hsieh, W. C., Huang, P. W., Lin, W. H., Wang, S. Y., et al. Development of oseltamivir phosphonate congeners as anti-influenza agents Journal of Medicinal Chemistry 2012 55:8657-8670 DOI:10.1021/jm3008486 PMID:23009169 PMCID:PMC3492761
- Liu, K. C., Fang, J. M., Jan, J. T., Cheng, T. J. R., Wang, S. Y., Yang, S. T., Cheng, Y. S. E., Wong, C. H. Enhanced anti-influenza agents conjugated with anti-inflammatory activity Journal of Medicinal Chemistry 2012 55:8493-8501 DOI:10.1021/jm3009844 PMID:22963087
- Hsieh, M. H., Hung, J. T., Liw, Y. W., Lu, Y. J., Wong, C. H., Yu, A. L., Liang, P. H. Synthesis and evaluation of acyl-chain- and galactose-6 ''-modified analogues of alpha-galcer for nkt cell activation ChemBioChem 2012 13:1689-1697 DOI:10.1002/cbic.201200004 PMID:22730199
- Zulueta, M. M. L., Lin, S. Y., Lin, Y. T., Huang, C. J., Wang, C. C., Ku, C. C., Shi, Z. H., Chyan, C. L., Irene, D., Lim, L. H., Tsai, T. I., Hu, Y. P., et al. Alpha-glycosylation by d-glucosamine-derived donors: Synthesis of heparosan and heparin analogues that interact with mycobacterial heparin-binding hemagglutinin Journal of the American Chemical Society 2012 134:8988-8995 DOI:10.1021/ja302640p PMID:22587381
- Huang, C. Y., Shih, H. W., Lin, L. Y., Tien, Y. W., Cheng, T. J. R., Cheng, W. C., Wong, C. H., Ma, C. Crystal structure of staphylococcus aureus transglycosylase in complex with a lipid ii analog and elucidation of peptidoglycan synthesis mechanism Proceedings of the National Academy of Sciences of the United States of America 2012 109:6496-6501 DOI:10.1073/pnas.1203900109 PMID:22493270 PMCID:PMC3340074
- Hsu, Y., Lu, X. A., Zulueta, M. M. L., Tsai, C. M., Lin, K. I., Hung, S. C., Wong, C. H. Acyl and silyl group effects in reactivity-based one-pot glycosylation: Synthesis of embryonic stem cell surface carbohydrates lc(4) and iv(2)fuc-lc(4) Journal of the American Chemical Society 2012 134:4549-4552 DOI:10.1021/ja300284x PMID:22390569
- Chen, S. H., Hwang, D. R., Chen, G. H., Hsu, N. S., Wu, Y. T., Li, T. L., Wong, C. H. Engineering transaldolase in Pichia stipitis to improve bioethanol production ACS Chemical Biology 2012 7:481-486 DOI:10.1021/cb200396b PMID:22148723
- Lenger, J., Schroder, M., Ennemann, E. C., Muller, B., Wong, C. H., Noll, T., Dierks, T., Hanson, S. R., Sewald, N. Evaluation of sulfatase-directed quinone methide traps for proteomics Bioorganic & Medicinal Chemistry 2012 20:622-627 DOI:10.1016/j.bmc.2011.04.044 PMID:21570853 PMCID:PMC3396293
- Shih, H. W., Chang, Y. F., Li, W. J., Meng, F. C., Huang, C. Y., Ma, C., Cheng, T. J. R., Wong, C. H., Cheng, W. C. Effect of the peptide moiety of lipid ii on bacterial transglycosylase Angewandte Chemie-International Edition 2012 51:10123-10126 DOI:10.1002/anie.201204038 PMID:22952114
- Price, J. L., Culyba, E. K., Chen, W., Murray, A. N., Hanson, S. R., Wong, C. H., Powers, E. T., Kelly, J. W. N-glycosylation of enhanced aromatic sequons to increase glycoprotein stability Biopolymers 2012 98:195-211 DOI:10.1002/bip.22030 PMID:22782562 PMCID:PMC3539202
- Punyadarsaniya, D., Liang, C. H., Winter, C., Petersen, H., Rautenschlein, S., Hennig-Pauka, I., Schwegmann-Wessels, C., Wu, C. Y., Wong, C. H., Herrler, G. Infection of differentiated porcine airway epithelial cells by influenza virus: Differential susceptibility to infection by porcine and avian viruses PLoS One 2011 6:e28429 DOI:10.1371/journal.pone.0028429 PMID:22174804 PMCID:PMC3235120
- Pejchal, R., Doores, K. J., Walker, L. M., Khayat, R., Huang, P. S., Wang, S. K., Stanfield, R. L., Julien, J. P., Ramos, A., Crispin, M., Depetris, R., Katpally, U., et al. A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield Science 2011 334:1097-1103 DOI:10.1126/science.1213256 PMID:21998254 PMCID:PMC3280215
- Shie, J. J., Fang, J. M., Lai, P. T., Wen, W. H., Wang, S. Y., Cheng, Y. S. E., Tsai, K. C., Yang, A. S., Wong, C. H. A practical synthesis of zanamivir phosphonate congeners with potent anti-influenza activity Journal of the American Chemical Society 2011 133:17959-17965 DOI:10.1021/ja207892q PMID:21942552
- Wu, T. N., Lin, K. H., Chang, Y. J., Huang, J. R., Cheng, J. Y., Yu, A. L., Wong, C. H. Avidity of cd1d-ligand-receptor ternary complex contributes to t-helper 1 (th1) polarization and anticancer efficacy Proceedings of the National Academy of Sciences of the United States of America 2011 108:17275-17280 DOI:10.1073/pnas.1114255108 PMID:21987790 PMCID:PMC3198369
- Meng, F. C., Chen, K. T., Huang, L. Y., Shih, H. W., Chang, H. H., Nien, F. Y., Liang, P. H., Cheng, T. J. R., Wong, C. H., Cheng, W. C. Total synthesis of polyprenyl n-glycolyl lipid ii as a mycobacterial transglycosylase substrate Organic Letters 2011 13:5306-5309 DOI:10.1021/ol2021687 PMID:21913698
- Shen, Y. F., Chen, Y. H., Chu, S. Y., Lin, M. I., Hsu, H. T., Wu, P. Y., Wu, C. J., Liu, H. W., Lin, F. Y., Lin, G., Hsu, P. H., Yang, A. S., et al. E339 ... R416 salt bridge of nucleoprotein as a feasible target for influenza virus inhibitors Proceedings of the National Academy of Sciences of the United States of America 2011 108:16515-16520 DOI:10.1073/pnas.1113107108 PMID:21930946 PMCID:PMC3189076
- Kinjo, Y., Illarionov, P., Vela, J. L., Pei, B., Girardi, E., Li, X. M., Li, Y. L., Imamura, M., Kaneko, Y., Okawara, A., Miyazaki, Y., Gomez-Velasco, A., et al. Invariant natural killer t cells recognize glycolipids from pathogenic gram-positive bacteria Nature Immunology 2011 12:966-974 DOI:10.1038/ni.2096 PMID:21892173 PMCID:PMC3178673
- Walker, L. M., Huber, M., Doores, K. J., Falkowska, E., Pejchal, R., Julien, J. P., Wang, S. K., Ramos, A., Chan-Hui, P. Y., Moyle, M., Mitcham, J. L., Hammond, P. W., et al. Broad neutralization coverage of HIV by multiple highly potent antibodies Nature 2011 477:466-470 DOI:10.1038/nature10373 PMID:21849977 PMCID:PMC3393110
- Shih, H. W., Chen, K. T., Cheng, T. J. R., Wong, C. H., Cheng, W. C. A new synthetic approach toward bacterial transglycosylase substrates, lipid ii and lipid iv Organic Letters 2011 13:4600-4603 DOI:10.1021/ol201806d PMID:21797279
- Chen, J. R., Ma, C., Wong, C. H. Vaccine design of hemagglutinin glycoprotein against influenza Trends in Biotechnology 2011 29:426-434 DOI:10.1016/j.tibtech.2011.04.007 PMID:21640418
- Yen, H. L., Liang, C. H., Wu, C. Y., Forrest, H. L., Ferguson, A., Choy, K. T., Jones, J., Wong, D. D. Y., Cheung, P. P. H., Hsu, C. H., Li, O. T., Yuen, K. M., et al. Hemagglutinin-neuraminidase balance confers respiratory-droplet transmissibility of the pandemic h1n1 influenza virus in ferrets Proceedings of the National Academy of Sciences of the United States of America 2011 108:14264-14269 DOI:10.1073/pnas.1111000108 PMID:21825167 PMCID:PMC3161546
- Liu, K. C., Lee, P. S., Wang, S. Y., Cheng, Y. S. E., Fang, J. M., Wong, C. H. Intramolecular ion-pair prodrugs of zanamivir and guanidino-oseltamivir Bioorganic & Medicinal Chemistry 2011 19:4796-4802 DOI:10.1016/j.bmc.2011.06.080 PMID:21778065
- Liu, Y. C., Yen, H. Y., Chen, C. Y., Chen, C. H., Cheng, P. F., Juan, Y. H., Khoo, K. H., Yu, C. J., Yang, P. C., Hsu, T. L., Wong, C. H. Sialylation and fucosylation of epidermal growth factor receptor suppress its dimerization and activation in lung cancer cells Proceedings of the National Academy of Sciences of the United States of America 2011 108:11332-11337 DOI:10.1073/pnas.1107385108 PMID:21709263 PMCID:PMC3136320
- Schmaltz, R. M., Hanson, S. R., Wong, C. H. Enzymes in the synthesis of glycoconjugates Chemical Reviews 2011 111:4259-4307 DOI:10.1021/cr200113w PMID:21749134
- Chang, C. F., Pan, J. F., Wu, I. L., Wong, C. H., Lin, C. H. Rapid characterization of sugar-binding specificity by in-solution proximity binding with photosensitizers Glycobiology 2011 21:895-902 DOI:10.1093/glycob/cwr021 PMID:21325337
- Tsai, B. L., Han, J. L., Ren, C. T., Wu, C. Y., Wong, C. H. Programmable one-pot synthesis of tumor-associated carbohydrate antigens lewis x dimer and kh-1 epitopes Tetrahedron Letters 2011 52:2132-2135 DOI:10.1016/j.tetlet.2010.11.055
- Chou, C. Y., Ko, T. P., Wu, K. J., Huang, K. F., Wong, C. H., Wang, A. H. J., Lin, C. H. Modulation of substrate specificities of D-sialic acid aldolase through single mutations of Val-251 Journal of Biological Chemistry 2011 286:14057-14064 DOI:10.1074/jbc.M110.179465 PMID:21270125 PMCID:PMC3077606
- Lee, R. T., Hsu, T. L., Huang, S. K., Hsieh, S. L., Wong, C. H., Lee, Y. C. Survey of immune-related, mannose/fucose-binding c-type lectin receptors reveals widely divergent sugar-binding specificities Glycobiology 2011 21:512-520 DOI:10.1093/glycob/cwq193 PMID:21112966 PMCID:PMC3055596
- Chen, M. W., Liao, H. Y., Huang, Y. X., Jan, J. T., Huang, C. C., Ren, C. T., Wu, C. Y., Cheng, T. J. R., Ho, D. D., Wong, C. H. Broadly neutralizing DNA vaccine with specific mutation alters the antigenicity and sugar-binding activities of influenza hemagglutinin Proceedings of the National Academy of Sciences of the United States of America 2011 108:3510-3515 DOI:10.1073/pnas.1019744108 PMID:21321237 PMCID:PMC3048126
- Culyba, E. K., Price, J. L., Hanson, S. R., Dhar, A., Wong, C. H., Gruebele, M., Powers, E. T., Kelly, J. W. Protein native-state stabilization by placing aromatic side chains in N-glycosylated reverse turns Science 2011 331:571-575 DOI:10.1126/science.1198461 PMID:21292975 PMCID:PMC3099596
- Wu, C. Y., Wong, C. H. Chemistry and glycobiology Chemical Communications 2011 47:6201-6207 DOI:10.1039/c0cc04359a PMID:21503322
- Liang, C. H., Wang, S. K., Lin, C. W., Wang, C. C., Wong, C. H., Wu, C. Y. Effects of neighboring glycans on antibody-carbohydrate interaction Angewandte Chemie-International Edition 2011 50:1608-1612 DOI:10.1002/anie.201003482 PMID:21308915
- Chu, K. C., Ren, C. T., Lu, C. P., Hsu, C. H., Sun, T. H., Han, J. L., Pal, B., Chao, T. A., Lin, Y. F., Wu, S. H., Wong, C. H., Wu, C. Y. Efficient and stereoselective synthesis of alpha(2 -> 9) oligosialic acids: From monomers to dodecamers Angewandte Chemie-International Edition 2011 50:9391-9395 DOI:10.1002/anie.201101794 PMID:21948436
- Hsu, J. W., Huang, H. C., Chen, S. T., Wong, C. H., Juan, H. F. Ganoderma lucidum polysaccharides induce macrophage-like differentiation in human leukemia thp-1 cells via caspase and p53 activation Evidence-Based Complementary and Alternative Medicine 2011 1-13 DOI:10.1093/ecam/nep107 PMID:19696196 PMCID:PMC3135330
- Hsu, C. H., Hung, S. C., Wu, C. Y., Wong, C. H. Toward automated oligosaccharide synthesis Angewandte Chemie-International Edition 2011 50:11872-11923 DOI:10.1002/anie.201100125 PMID:22127846
- Chen, W. Y., Yang, W. B., Wong, C. H., Shih, D. T. B. Effect of reishi polysaccharides on human stem/progenitor cells Bioorganic & Medicinal Chemistry 2010 18:8583-8591 DOI:10.1016/j.bmc.2010.10.016 PMID:21055951
- Cheng, T. J. R., Wu, Y. T., Yang, S. T., Lo, K. H., Chen, S. K., Chen, Y. H., Huang, W. I., Yuan, C. H., Guo, C. W., Huang, L. Y., Chen, K. T., Shih, H. W., et al. High-throughput identification of antibacterials against methicillin-resistant staphylococcus aureus (mrsa) and the transglycosylase Bioorganic & Medicinal Chemistry 2010 18:8512-8529 DOI:10.1016/j.bmc.2010.10.036 PMID:21075637
- Lewis, J. C., Mantovani, S. M., Fu, Y., Snow, C. D., Komor, R. S., Wong, C. H., Arnold, F. H. Combinatorial alanine substitution enables rapid optimization of cytochrome p450(bm3) for selective hydroxylation of large substrates ChemBioChem 2010 11:2502-2505 DOI:10.1002/cbic.201000565 PMID:21108271 PMCID:PMC4447097
- Schelwies, M., Brinson, D., Otsuki, S., Hong, Y. H., Lotz, M. K., Wong, C. H., Hanson, S. R. Glucosamine-6-sulfamate analogues of heparan sulfate as inhibitors of endosulfatases ChemBioChem 2010 11:2393-2397 DOI:10.1002/cbic.201000401 PMID:20973023 PMCID:PMC3086843
- Su, C. Y., Cheng, T. J. R., Lin, M. I., Wang, S. Y., Huang, W. I., Lin-Chu, S. Y., Chen, Y. H., Wu, C. Y., Lai, M. M. C., Cheng, W. C., Wu, Y. T., Tsai, M. D., et al. High-throughput identification of compounds targeting influenza rna-dependent rna polymerase activity Proceedings of the National Academy of Sciences of the United States of America 2010 107:19151-19156 DOI:10.1073/pnas.1013592107 PMID:20974907 PMCID:PMC2984200
- Liao, H. Y., Hsu, C. H., Wang, S. C., Liang, C. H., Yen, H. Y., Su, C. Y., Chen, C. H., Jan, J. T., Ren, C. T., Cheng, T. J. R., Wu, C. Y., Wong, C. H. Differential receptor binding affinities of influenza hemagglutinins on glycan arrays Journal of the American Chemical Society 2010 132:14849-14856 DOI:10.1021/ja104657b PMID:20882975
- Shie, J. J., Chen, C. A., Lin, C. C., Ku, A. F., Cheng, T. J. R., Fang, J. M., Wong, C. H. Regioselective synthesis of di-c-glycosylflavones possessing anti-inflammation activities Organic & Biomolecular Chemistry 2010 8:4451-4462 DOI:10.1039/c0ob00011f PMID:20725659
- Lin, K. H., Liang, J. J., Huang, W. I., Lin-Chu, S. Y., Su, C. Y., Lee, Y. L., Jan, J. T., Lin, Y. L., Cheng, Y. S. E., Wong, C. H. In vivo protection provided by a synthetic new alpha-galactosyl ceramide analog against bacterial and viral infections in murine models Antimicrobial Agents and Chemotherapy 2010 54:4129-4136 DOI:10.1128/aac.00368-10 PMID:20660669 PMCID:PMC2944612
- Chang, S. H., Han, J. L., Tseng, S. Y., Lee, H. Y., Lin, C. W., Lin, Y. C., Jeng, W. Y., Wang, A. H. J., Wu, C. Y., Wong, C. H. Glycan array on aluminum oxide-coated glass slides through phosphonate chemistry Journal of the American Chemical Society 2010 132:13371-13380 DOI:10.1021/ja1046523 PMID:20822102
- Li, X. M., Fujio, M., Imamura, M., Wu, D., Vasan, S., Wong, C. H., Ho, D. D., Tsuji, M. Design of a potent CD1d-binding NKT cell ligand as a vaccine adjuvant Proceedings of the National Academy of Sciences of the United States of America 2010 107:13010-13015 DOI:10.1073/pnas.1006662107 PMID:20616071 PMCID:PMC2919905
- Wen, W. H., Wang, S. Y., Tsai, K. C., Cheng, Y. S. E., Yang, A. S., Fang, J. M., Wong, C. H. Analogs of zanamivir with modified c4-substituents as the inhibitors against the group-1 neuraminidases of influenza viruses Bioorganic & Medicinal Chemistry 2010 18:4074-4084 DOI:10.1016/j.bmc.2010.04.010 PMID:20452227
- Otsuki, S., Hanson, S. R., Miyaki, S., Grogan, S. P., Kinoshita, M., Asahara, H., Wong, C. H., Lotz, M. K. Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways Proceedings of the National Academy of Sciences of the United States of America 2010 107:10202-10207 DOI:10.1073/pnas.0913897107 PMID:20479257 PMCID:PMC2890424
- Astronomo, R. D., Kaltgrad, E., Udit, A. K., Wang, S. K., Doores, K. J., Huang, C. Y., Pantophlet, R., Paulson, J. C., Wong, C. H., Finn, M. G., Burton, D. R. Defining criteria for oligomannose immunogens for HIV using icosahedral virus capsid scaffolds Chemistry & Biology 2010 17:357-370 DOI:10.1016/j.chembiol.2010.03.012 PMID:20416507 PMCID:PMC2867452
- Liu, C. Y., Guo, C. W., Chang, Y. F., Wang, J. T., Shih, H. W., Hsu, Y. F., Chen, C. W., Chen, S. K., Wang, Y. C., Cheng, T. J. R., Ma, C., Wong, C. H., et al. Synthesis and evaluation of a new fluorescent transglycosylase substrate: Lipid ii-based molecule possessing a dansyl-c20 polyprenyl moiety Organic Letters 2010 12:1608-1611 DOI:10.1021/ol100338v PMID:20187630
- Chang, C. C., Ku, A. F., Tseng, Y. Y., Yang, W. B., Fang, J. M., Wong, C. H. 6,8-di-C-glycosyl flavonoids from Dendrobium huoshanense Journal of Natural Products 2010 73:229-232 DOI:10.1021/np900252f PMID:20055483
- Payne, R. J., Wong, C. H. Advances in chemical ligation strategies for the synthesis of glycopeptides and glycoproteins Chemical Communications 2010 46:21-43 DOI:10.1039/b913845e PMID:20024291
- Shih, H. W., Chen, K. T., Chen, S. K., Huang, C. Y., Cheng, T. J. R., Ma, C., Wong, C. H., Cheng, W. C. Combinatorial approach toward synthesis of small molecule libraries as bacterial transglycosylase inhibitors Organic & Biomolecular Chemistry 2010 8:2586-2593 DOI:10.1039/c000622j PMID:20485795
- Tsai, C. S., Liu, P. Y., Yen, H. Y., Hsu, T. L., Wong, C. H. Development of trifunctional probes for glycoproteomic analysis Chemical Communications 2010 46:5575-5577 DOI:10.1039/c0cc00345j PMID:20467665
- Hsu, C. H., Chu, K. C., Lin, Y. S., Han, J. L., Peng, Y. S., Ren, C. T., Wu, C. Y., Wong, C. H. Highly alpha-selective sialyl phosphate donors for efficient preparation of natural sialosides Chemistry-a European Journal 2010 16:1754-1760 DOI:10.1002/chem.200903035 PMID:20066711
- Hsu, T. L., Cheng, S. C., Yang, W. B., Chin, S. W., Chen, B. H., Huang, M. T., Hsieh, S. L., Wong, C. H. Profiling carbohydrate-receptor interaction with recombinant innate immunity receptor-fc fusion proteins Journal of Biological Chemistry 2009 284:34479-34489 DOI:10.1074/jbc.M109.065961 PMID:19837675 PMCID:PMC2787309
- Schiefner, A., Fujio, M., Wu, D., Wong, C. H., Wilson, I. A. Structural evaluation of potent NKT cell agonists: Implications for design of novel stimulatory ligands Journal of Molecular Biology 2009 394:71-82 DOI:10.1016/j.jmb.2009.08.061 PMID:19732779 PMCID:PMC2792987
- Chuang, M. H., Chiou, S. H., Huang, C. H., Yang, W. B., Wong, C. H. The lifespan-promoting effect of acetic acid and reishi polysaccharide Bioorganic & Medicinal Chemistry 2009 17:7831-7840 DOI:10.1016/j.bmc.2009.09.002 PMID:19837596
- Wang, C. C., Chen, J. R., Tseng, Y. C., Hsu, C. H., Hung, Y. F., Chen, S. W., Chen, C. M., Khoo, K. H., Cheng, T. J., Cheng, Y. S. E., Jan, J. T., Wu, C. Y., et al. Glycans on influenza hemagglutinin affect receptor binding and immune response Proceedings of the National Academy of Sciences of the United States of America 2009 106:18137-18142 DOI:10.1073/pnas.0909696106 PMID:19822741 PMCID:PMC2775302
- Lewis, J. C., Bastian, S., Bennett, C. S., Fu, Y., Mitsuda, Y., Chen, M. M., Greenberg, W. A., Wong, C. H., Arnold, F. H. Chemoenzymatic elaboration of monosaccharides using engineered cytochrome p450(bm3) demethylases Proceedings of the National Academy of Sciences of the United States of America 2009 106:16550-16555 DOI:10.1073/pnas.0908954106 PMID:19805336 PMCID:PMC2757845
- Liang, C. H., Wang, C. C., Lin, Y. C., Chen, C. H., Wong, C. H., Wu, C. Y. Iron oxide/gold core/shell nanoparticles for ultrasensitive detection of carbohydrate-protein interactions Analytical Chemistry 2009 81:7750-7756 DOI:10.1021/ac9012286 PMID:19689135
- Wen, W. H., Lin, M. G., Su, C. Y., Wang, S. Y., Cheng, Y. S. E., Fang, J. M., Wong, C. H. Synergistic effect of zanamivir-porphyrin conjugates on inhibition of neuraminidase and inactivation of influenza virus Journal of Medicinal Chemistry 2009 52:4903-4910 DOI:10.1021/jm900515g PMID:19522501
- Hong, Z. Y., Liu, L., Sugiyama, M., Fu, Y., Wong, C. H. Concise synthesis of iminocyclitols via petasis-type aminocyclization Journal of the American Chemical Society 2009 131:8352-8353 DOI:10.1021/ja901656e PMID:19530721 PMCID:PMC2900252
- Sung, M. T., Lai, Y. T., Huang, C. Y., Chou, L. Y., Shih, H. W., Cheng, W. C., Wong, C. H., Ma, C. Crystal structure of the membrane-bound bifunctional transglycosylase pbp1b from escherichia coli Proceedings of the National Academy of Sciences of the United States of America 2009 106:8824-8829 DOI:10.1073/pnas.0904030106 PMID:19458048 PMCID:PMC2689995
- Hanson, S. R., Culyba, E. K., Hsu, T. L., Wong, C. H., Kelly, J. W., Powers, E. T. The core trisaccharide of an N-linked glycoprotein intrinsically accelerates folding and enhances stability Proceedings of the National Academy of Sciences of the United States of America 2009 106:3131-3136 DOI:10.1073/pnas.0810318105 PMID:19204290 PMCID:PMC2651298
- Wang, S. Y., Su, C. Y., Lin, M. G., Huang, S. Y., Huang, W. I., Wang, C. C., Wu, Y. T., Cheng, T. J. R., Yu, H. M., Ren, C. T., Wu, C. Y., Wong, C. H., et al. Ha-pseudotyped retroviral vectors for influenza antagonist screening Journal of Biomolecular Screening 2009 14:294-302 DOI:10.1177/1087057108330786 PMID:19211776
- Motiei, L., Rahimipour, S., Thayer, D. A., Wong, C. H., Ghadiri, M. R. Antibacterial cyclic D,L-alpha-glycopeptides Chemical Communications 2009 3693-3695 DOI:10.1039/b902455g PMID:19557251 PMCID:PMC2758689
- Wong, C. H. Enzymes for glycoprotein synthesis Chimia 2009 63:318-326 DOI:10.2533/chimia.2009.318
- Wu, C. Y., Liang, P. H., Wong, C. H. New development of glycan arrays Organic & Biomolecular Chemistry 2009 7:2247-2254 DOI:10.1039/b902510n PMID:19462030
- Tupin, E., Benhnia, M. R., Kinjo, Y., Patsey, R., Lena, C. J., Haller, M. C., Caimano, M. J., Imamura, M., Wong, C. H., Crotty, S., Radolf, J. D., Sellati, T. J., et al. Nkt cells prevent chronic joint inflammation after infection with borrelia burgdorferi Proceedings of the National Academy of Sciences of the United States of America 2008 105:19863-19868 DOI:10.1073/pnas.0810519105 PMID:19060201 PMCID:PMC2604993
- Shi, C. S., Shi, G. Y., Hsiao, S. M., Kao, Y. C., Kuo, K. L., Ma, C. Y., Kuo, C. H., Chang, B. I., Chang, C. F., Wong, C. H., Wu, H. L., Lin, C. H. Lectin-like domain of thrombomodulin binds to its specific ligand Lewis Y antigen and neutralizes lipopolysaccharide-induced inflammatory response Blood 2008 112:3661-3670 DOI:10.1182/blood-2008-03-142760 PMID:18711002 PMCID:PMC2572793
- Giffin, M. J., Heaslet, H., Brik, A., Lin, Y. C., Cauvi, G., Wong, C. H., McRee, D. E., Elder, J. H., Stout, C. D., Torbett, B. E. A copper(I)-catalyzed 1,2,3-triazole azide-alkyne click compound is a potent inhibitor of a multidrug-resistant HIV-1 protease variant Journal of Medicinal Chemistry 2008 51:6263-6270 DOI:10.1021/jm800149m PMID:18823110 PMCID:PMC2744648
- Liang, P. H., Imamura, M., Li, X. M., Wu, D., Fujio, M., Guy, R. T., Wu, B. C., Tsuji, M., Wong, C. H. Quantitative microarray analysis of intact glycolipid-CD1d interaction and correlation with cell-based cytokine production Journal of the American Chemical Society 2008 130:12348-12354 DOI:10.1021/ja8012787 PMID:18712867 PMCID:PMC4455950
- Bennett, C. S., Dean, S. M., Payne, R. J., Ficht, S., Brik, A., Wong, C. H. Sugar-assisted glycopeptide ligation with complex oligosaccharides: Scope and limitations Journal of the American Chemical Society 2008 130:11945-11952 DOI:10.1021/ja8010513 PMID:18698778 PMCID:PMC2577756
- Chen, M. W., Cheng, T. J. R., Huang, Y. X., Jan, J. T., Ma, S. H., Yu, A. L., Wong, C. H., Ho, D. D. A consensus-hemagglutinin-based DNA vaccine that protects mice against divergent H5N1 influenza viruses Proceedings of the National Academy of Sciences of the United States of America 2008 105:13538-13543 DOI:10.1073/pnas.0806901105 PMID:18765801 PMCID:PMC2533225
- Su, C. Y., Wang, S. Y., Shie, J. J., Jeng, K. S., Temperton, N. J., Fang, J. M., Wong, C. H., Cheng, Y. S. E. In vitro evaluation of neuraminidase inhibitors using the neuraminidase-dependent release assay of hemagglutinin-pseudotyped viruses Antiviral Research 2008 79:199-205 DOI:10.1016/j.antiviral.2008.03.002 PMID:18453004
- Wang, C. C., Huang, Y. L., Ren, C. T., Lin, C. W., Hung, J. T., Yu, J. C., Yu, A. L., Wu, C. Y., Wong, C. H. Glycan microarray of globo h and related structures for quantitative analysis of breast cancer Proceedings of the National Academy of Sciences of the United States of America 2008 105:11661-11666 DOI:10.1073/pnas.0804923105 PMID:18689688 PMCID:PMC2575271
- Kinjo, Y., Pei, B., Bufali, S., Raju, R., Richardson, S. K., Imamura, M., Fujio, M., Wu, D., Khurana, A., Kawahara, K., Wong, C. H., Howell, A. R., et al. Natural sphingomonas glycolipids vary greatly in their ability to activate natural killer T cells Chemistry & Biology 2008 15:654-664 DOI:10.1016/j.chembiol.2008.05.012 PMID:18635002 PMCID:PMC2519143
- Astronomo, R. D., Lee, H. K., Scanlan, C. N., Pantophlet, R., Huang, C. Y., Wilson, I. A., Blixt, O., Dwek, R. A., Wong, C. H., Burton, D. R. A glycoconjugate antigen based on the recognition motif of a broadly neutralizing human immunodeficiency virus antibody, 2g12, is immunogenic but elicits antibodies unable to bind to the self glycans of gp120 Journal of Virology 2008 82:6359-6368 DOI:10.1128/jvi.00293-08 PMID:18434393 PMCID:PMC2447108
- Hsu, N. F., Tseng, S. Y., Wu, C. Y., Ren, C. T., Lee, Y. C., Wong, C. H., Chen, C. H. Desorption ionization of biomolecules on metals Analytical Chemistry 2008 80:5203-5210 DOI:10.1021/ac800435r PMID:18489127
- Sugiyama, M., Greenberg, W., Wong, C. H. Recent advances in aldolase-catalyzed synthesis of unnatural sugars and iminocyclitols Journal of Synthetic Organic Chemistry Japan 2008 66:605-615
- Hsieh, Y. S. Y., Chien, C., Liao, S. K. S., Liao, S. F., Hung, W. T., Yang, W. B., Lin, C. C., Cheng, T. J. R., Chang, C. C., Fang, J. M., Wong, C. H. Structure and bioactivity of the polysaccharides in medicinal plant dendrobium huoshanense Bioorganic & Medicinal Chemistry 2008 16:6054-6068 DOI:10.1016/j.bmc.2008.04.042 PMID:18467102
- Chen, S. T., Lin, Y. L., Huang, M. T., Wu, M. F., Cheng, S. C., Lei, H. Y., Lee, C. K., Chiou, T. W., Wong, C. H., Hsieh, S. L. Clec5a is critical for dengue-virus-induced lethal disease Nature 2008 453:672-676 DOI:10.1038/nature07013 PMID:18496526
- Shao, Y. M., Yang, W. B., Kuo, T. H., Tsai, K. C., Yang, A. S., Liang, P. H., Wong, C. H., Lin, C. H. Design, synthesis, and evaluation of trifluoromethyl ketones as inhibitors of SARS-CoV 3CL protease Bioorganic & Medicinal Chemistry 2008 16:4652-4660 DOI:10.1016/j.bmc.2008.02.040 PMID:18329272
- Northen, T. R., Lee, J. C., Hoang, L., Raymond, J., Hwang, D. R., Yannone, S. M., Wong, C. H., Siuzdak, G. A nanostructure-initiator mass spectrometry-based enzyme activity assay Proceedings of the National Academy of Sciences of the United States of America 2008 105:3678-3683 DOI:10.1073/pnas.0712332105 PMID:18319341 PMCID:PMC2268803
- Wang, S. K., Liang, P. H., Astronomo, R. D., Hsu, T. L., Hsieh, S. L., Burton, D. R., Wong, C. H. Targeting the carbohydrates on HIV-1: Interaction of oligomannose dendrons with human monoclonal antibody 2G12 and DC-SIGN Proceedings of the National Academy of Sciences of the United States of America 2008 105:3690-3695 DOI:10.1073/pnas.0712326105 PMID:18310320 PMCID:PMC2268808
- Liang, P. H., Wu, C. Y., Greenberg, W. A., Wong, C. H. Glycan arrays: Biological and medical applications Current Opinion in Chemical Biology 2008 12:86-92 DOI:10.1016/j.cbpa.2008.01.031 PMID:18258211
- Wu, D., Fujio, M., Wong, C. H. Glycolipids as immunostimulating agents Bioorganic & Medicinal Chemistry 2008 16:1073-1083 DOI:10.1016/j.bmc.2007.10.026 PMID:18006319 PMCID:PMC2279229
- Cheng, T. J. R., Sung, M. T., Liao, H. Y., Chang, Y. F., Chen, C. W., Huang, C. Y., Chou, L. Y., Wu, Y. D., Chen, Y., Cheng, Y. S. E., Wong, C. H., Ma, C., et al. Domain requirement of moenomycin binding to bifunctional transglycosylases and development of high-throughput discovery of antibiotics Proceedings of the National Academy of Sciences of the United States of America 2008 105:431-436 DOI:10.1073/pnas.0710868105 PMID:18182485 PMCID:PMC2206553
- Shie, J. J., Fang, J. M., Wong, C. H. A concise and flexible synthesis of the potent anti-influenza agents tamiflu and tamiphosphor Angewandte Chemie-International Edition 2008 47:5788-5791 DOI:10.1002/anie.200801959 PMID:18613158
- Payne, R. J., Ficht, S., Greenberg, W. A., Wong, C. H. Cysteine-free peptide and glycopeptide ligation by direct aminolysis Angewandte Chemie-International Edition 2008 47:4411-4415 DOI:10.1002/anie.200705298 PMID:18442150
- Chang, W. W., Lee, C. H., Lee, P. S., Lin, J. W., Hsu, C. W., Hung, J. T., Lin, J. J., Yu, J. C., Shao, L. E., Wong, C. H., Yu, A. L. Expression of Globo H and SSEA3 in breast cancer stem cells and the involvement of fucosyl transferases 1 and 2 in Globo H synthesis Proceedings of the National Academy of Sciences of the United States of America 2008 105:11667-11672 DOI:10.1073/pnas.0804979105 PMID:18685093 PMCID:PMC2575305
- Chen, M. L., Adak, A. K., Yeh, N. C., Yang, W. B., Chuang, Y. J., Wong, C. H., Hwang, K. C., Hwu, J. R. R., Hsieh, S. L., Lin, C. C. Fabrication of an oriented Fc-fused lectin microarray through boronate formation. Angewandte Chemie-International Edition 2008 47:8627-8630 DOI:10.1002/anie.200803377 PMID:18850623
- Tseng, S. Y., Wang, C. C., Lin, C. W., Chen, C. L., Yu, W. Y., Chen, C. H., Wu, C. Y., Wong, C. H. Glycan arrays on aluminum-coated glass slides Chemistry-an Asian Journal 2008 3:1395-1405 DOI:10.1002/asia.200800154 PMID:18683161
- Ficht, S., Payne, R. J., Guy, R. T., Wong, C. H. Solid-phase synthesis of peptide and glycopeptide thioesters through side-chain-anchoring strategies Chemistry-a European Journal 2008 14:3620-3629 DOI:10.1002/chem.200701978 PMID:18278777
- Hanson, S. R., Greenberg, W. A., Wong, C. H. Probing glycans with the copper(i)-catalyzed 3+2 azide-alkyne cycloaddition QSAR & Combinatorial Science 2007 26:1243-1252 DOI:10.1002/qsar.200740112
- Sugiyama, M., Hong, Z., Liang, P. H., Dean, S. M., Whalen, L. J., Greenberg, W. A., Wong, C. H. D-fructose-6-phosphate aldolase-catalyzed one-pot synthesis of iminocyclitols Journal of the American Chemical Society 2007 129:14811-14817 DOI:10.1021/ja073911i PMID:17985886
- Cheng, K. C., Huang, H. C., Chen, J. H., Hsu, J. W., Cheng, H. C., Ou, C. H., Yang, W. B., Chen, S. T., Wong, C. H., Juan, H. F. Ganoderma lucidum polysaccharides in human monocytic leukemia cells: From gene expression to network construction BMC Genomics 2007 8:411 DOI:10.1186/1471-2164-8-411 PMID:17996095 PMCID:PMC2211495
- Payne, R. J., Ficht, S., Tang, S., Brik, A., Yang, Y. Y., Case, D. A., Wong, C. H. Extended sugar-assisted glycopeptide ligations: Development, scope, and applications Journal of the American Chemical Society 2007 129:13527-13536 DOI:10.1021/ja073653p PMID:17935327
- Polat, T., Wong, C. H. Anomeric reactivity-based one-pot synthesis of heparin-like oligosaccharides Journal of the American Chemical Society 2007 129:12795-12800 DOI:10.1021/ja073098r PMID:17914818 PMCID:PMC2525852
- Shie, J. J., Fang, J. M., Wang, S. Y., Tsai, K. C., Cheng, Y. S. E., Yang, A. S., Hsiao, S. C., Su, C. Y., Wong, C. H. Synthesis of tamiflu and its phosphonate congeners possessing potent anti-influenza activity Journal of the American Chemical Society 2007 129:11892-11893 DOI:10.1021/ja073992i PMID:17850083
- Shao, Y. M., Yang, W. B., Peng, H. P., Hsu, M. F., Tsa, K. C., Kuo, T. H., Wang, A. H. J., Liang, P. H., Yang, A. S., Wong, C. H., Lin, C. H. Structure-based design and synthesis of highly potent SARS-CoV 3CL protease inhibitors ChemBioChem 2007 8:1654-1657 DOI:10.1002/cbic.200700254 PMID:17722121
- Liang, P. H., Wang, S. K., Wong, C. H. Quantitative analysis of carbohydrate-protein interactions using glycan microarrays: Determination of surface and solution dissociation constants Journal of the American Chemical Society 2007 129:11177-11184 DOI:10.1021/ja072931h PMID:17705486
- Sugiyama, M., Hong, Z. Y., Greenberg, W. A., Wong, C. H. In vivo selection for the directed evolution of l-rhamnulose aldolase from l-rhamnulose-1-phosphate aldolase (rhad) Bioorganic & Medicinal Chemistry 2007 15:5905-5911 DOI:10.1016/j.bmc.2007.05.062 PMID:17572092 PMCID:PMC1992742
- Wei, M. T., Hua, K. F., Hsu, J., Karmenyan, A., Tseng, K. Y., Wong, C. H., Hsu, H. Y., Chiou, A. The interaction of lipopolysaccharide with membrane receptors on macrophages pre-treated with extract of reishi polysaccharides measured by optical tweezers Optics Express 2007 15:11020-11032 DOI:10.1364/oe.15.011020 PMID:19547459
- Kaltgrad, E., Sen Gupta, S., Punna, S., Huang, C. Y., Chang, A., Wong, C. H., Finn, M. G., Blixt, O. Anti-carbohydrate antibodies elicited by polyvalent display on a viral scaffold ChemBioChem 2007 8:1455-1462 DOI:10.1002/cbic.200700225 PMID:17676704
- Hua, K. F., Hsu, H. Y., Chao, L. K., Chen, S. T., Yang, W. B., Hsu, J., Wong, C. H. Ganoderma lucidum polysaccharides enhance cd14 endocytosis of lps and promote tlr4 signal transduction of cytokine expression Journal of Cellular Physiology 2007 212:537-550 DOI:10.1002/jcp.21050 PMID:17474083
- Yang, Y. Y., Ficht, S., Brik, A., Wong, C. H. Sugar-assisted ligation in glycoprotein synthesis Journal of the American Chemical Society 2007 129:7690-7701 DOI:10.1021/ja0708971 PMID:17523644 PMCID:PMC2553000
- Chang, Y. J., Huang, J. R., Tsai, Y. C., Hung, J. T., Wu, D., Fujio, M., Wong, C. H., Yu, A. L. Potent immune-modulating and anticancer effects of NKT cell stimulatory glycolipids Proceedings of the National Academy of Sciences of the United States of America 2007 104:10299-10304 DOI:10.1073/pnas.0703824104 PMID:17566107 PMCID:PMC1965507
- Hanson, S. R., Hsu, T. L., Weerapana, E., Kishikawa, K., Simon, G. M., Cravatt, B. F., Wong, C. H. Tailored glycoproteomics and glycan site mapping using saccharide-selective bioorthogonal probes Journal of the American Chemical Society 2007 129:7266-7267 DOI:10.1021/ja0724083 PMID:17506567 PMCID:PMC2552998
- Dean, S. M., Greenberg, W. A., Wong, C. H. Recent advances in aldolase-catalyzed asymmetric synthesis Advanced Synthesis & Catalysis 2007 349:1308-1320 DOI:10.1002/adsc.200700115
- Michel, M. L., Keller, A. C., Paget, C., Fujio, M., Trottein, F., Savage, P. B., Wong, C. H., Schneider, E., Dy, M., Leite-De-Moraes, M. C. Identification of an il-17-producing nk1.1(neg) inkt cell population involved in airway neutrophilia Journal of Experimental Medicine 2007 204:995-1001 DOI:10.1084/jem.20061551 PMID:17470641 PMCID:PMC2118594
- Hsu, T. L., Hanson, S. R., Kishikawa, K., Wang, S. K., Sawa, M., Wong, C. H. Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells Proceedings of the National Academy of Sciences of the United States of America 2007 104:2614-2619 DOI:10.1073/pnas.0611307104 PMID:17296930 PMCID:PMC1815231
- Yu, Z. Q., Sawkar, A. R., Whalen, L. J., Wong, C. H., Kelly, J. W. Isofagomine- and 2,5-anhydro-2,5-imino-D-glucitol-based glucocerebrosidase pharmacological chaperones for Gaucher disease intervention Journal of Medicinal Chemistry 2007 50:94-100 DOI:10.1021/jm060677i PMID:17201413 PMCID:PMC2543937
- Bennett, C. S., Wong, C. H. Chemoenzymatic approaches to glycoprotein synthesis Chemical Society Reviews 2007 36:1227-1238 DOI:10.1039/b617709c PMID:17619683
- Thayer, D. A., Wong, C. H. Enzymatic synthesis of glycopeptides and glycoproteins Topics in Current Chemistry 2007 267:37-63 DOI:10.1007/128_032
- Hsu, N. Y., Yang, W. B., Wong, C. H., Lee, Y. C., Lee, R. T., Wang, Y. S., Chen, C. H. Matrix-assisted laser desorption/ionization mass spectrometry of polysaccharides with 2',4',6'-trihydroxyacetophenone as matrix Rapid Communications in Mass Spectrometry 2007 21:2137-2146 DOI:10.1002/rcm.3072 PMID:17546658
- Ficht, S., Payne, R. J., Brik, A., Wong, C. H. Second-generation sugar-assisted ligation: A method for the synthesis of cysteine-containing glycopeptides Angewandte Chemie-International Edition 2007 46:5975-5979 DOI:10.1002/anie.200700546 PMID:17607677
- Brik, A., Wong, C. H. Sugar-assisted ligation for the synthesis of glycopeptides Chemistry-a European Journal 2007 13:5670-5675 DOI:10.1002/chem.200700330 PMID:17508364
- Hanson, S. R., Whalen, L. J., Wong, C. H. Synthesis and evaluation of general mechanism-based inhibitors of sulfatases based on (difluoro)methyl phenyl sulfate and cyclic phenyl sulfamate motifs Bioorganic & Medicinal Chemistry 2006 14:8386-8395 DOI:10.1016/j.bmc.2006.09.002 PMID:17045481 PMCID:PMC2675284
- Sugiyama, M., Hong, Z. Y., Whalen, L. J., Greenberg, W. A., Wong, C. H. Borate as a phosphate ester mimic in aldolase-catalyzed reactions: Practical synthesis of l-fructose and l-iminocyclitols Advanced Synthesis & Catalysis 2006 348:2555-2559 DOI:10.1002/adsc.200600356
- Brik, A., Ficht, S., Wong, C. H. Strategies for the preparation of homogenous glycoproteins Current Opinion in Chemical Biology 2006 10:638-644 DOI:10.1016/j.cbpa.2006.10.003 PMID:17046315
- Brik, A., Ficht, S., Yang, Y. Y., Bennett, C. S., Wong, C. H. Sugar-assisted ligation of N-linked glycopeptides with broad sequence tolerance at the ligation junction Journal of the American Chemical Society 2006 128:15026-15033 DOI:10.1021/ja065601q PMID:17105315
- Liu, H. T., Wong, C. H. Characterization of a transglycosylase domain of Streptococcus pneumoniae PBP1b Bioorganic & Medicinal Chemistry 2006 14:7187-7195 DOI:10.1016/j.bmc.2006.06.058 PMID:16870450
- Cheng, Y. S. E., Lo, K. H., Hsu, H. H., Shao, Y. M., Yang, W. B., Wong, C. H., Lin, C. H. Screening for HIV protease inhibitors by protection against activity-mediated cytotoxicity in Escherichia coli Journal of Virological Methods 2006 137:82-87 DOI:10.1016/j.jviromet.2006.06.003 PMID:16849028
- Huang, K. T., Wu, B. C., Lin, C. C., Luo, S. C., Chen, C. P., Wong, C. H. Multi-enzyme one-pot strategy for the synthesis of sialyl Lewis X-containing PSGL-1 glycopeptide Carbohydrate Research 2006 341:2151-2155 DOI:10.1016/j.carres.2006.04.047 PMID:16762328
- Kinjo, Y., Tupin, E., Wu, D., Fujio, M., Garcia-Navarro, R., Benhnia, Mrei, Zajonc, D. M., Ben-Menachem, G., Ainge, G. D., Painter, G. F., Khurana, A., Hoebe, K., et al. Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria Nature Immunology 2006 7:978-986 DOI:10.1038/ni1380 PMID:16921381
- Thayer, D. A., Wong, C. H. Vancomycin analogues containing monosaccharides exhibit improved antibiotic activity: A combined one-pot enzymatic glycosylation and chemical diversification strategy Chemistry-an Asian Journal 2006 1:445-452 DOI:10.1002/asia.200600084 PMID:17441081
- Lin, K. I., Kao, Y. Y., Kuo, H. K., Yang, W. B., Chou, A., Lin, H. H., Yu, A. L., Wong, C. H. Reishi polysaccharides induce immunoglobulin production through the tlr4/tlr2-mediated induction of transcription factor blimp-1 Journal of Biological Chemistry 2006 281:24111-24123 DOI:10.1074/jbc.M601106200 PMID:16798741
- Liang, F. S., Greenberg, W. A., Hammond, J. A., Hoffmann, J., Head, S. R., Wong, C. H. Evaluation of rna-binding specificity of aminoglycosides with DNA microarrays Proceedings of the National Academy of Sciences of the United States of America 2006 103:12311-12316 DOI:10.1073/pnas.0605264103 PMID:16891415 PMCID:PMC1567877
- Sawa, M., Hsu, T. L., Itoh, T., Sugiyama, M., Hanson, S. R., Vogt, P. K., Wong, C. H. Glycoproteomic probes for fluorescent imaging of fucosylated glycans in vivo Proceedings of the National Academy of Sciences of the United States of America 2006 103:12371-12376 DOI:10.1073/pnas.0605418103 PMID:16895981 PMCID:PMC1567886
- Lin, Y. C., Brik, A., de Parseval, A., Tam, K., Torbett, B. E., Wong, C. H., Elder, J. H. Altered gag polyprotein cleavage specificity of feline immunodeficiency virus/human immunodeficiency virus mutant proteases as demonstrated in a cell-based expression system Journal of Virology 2006 80:7832-7843 DOI:10.1128/jvi.00374-06 PMID:16873240 PMCID:PMC1563824
- Sanna, M. G., Wang, S. K., Gonzalez-Cabrera, P. J., Don, A., Marsolais, D., Matheu, M. P., Wei, S. H., Parker, I., Jo, E. J., Cheng, W. C., Cahalan, M. D., Wong, C. H., et al. Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P(1) antagonist in vivo Nature Chemical Biology 2006 2:434-441 DOI:10.1038/nchembio804 PMID:16829954
- Fujio, M., Wu, D. G., Garcia-Navarro, R., Ho, D. D., Tsuji, M., Wong, C. H. Structure-based discovery of glycolipids for CD1d-mediated NKT cell activation: Tuning the adjuvant versus immunosuppression activity Journal of the American Chemical Society 2006 128:9022-9023 DOI:10.1021/ja062740z PMID:16834361
- Qiu, H., Gabrielsen, A., Agardh, H. E., Wan, M., Wetterholm, A., Wong, C. H., Hedin, U., Swedenborg, J., Hansson, G. K., Samuelsson, B., Paulsson-Berne, G., Haeggstrom, J. Z. Expression of 5-lipoxygenase and leukotriene a(4) hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability Proceedings of the National Academy of Sciences of the United States of America 2006 103:8161-8166 DOI:10.1073/pnas.0602414103 PMID:16698924 PMCID:PMC1459628
- Hsu, H. Y., Hua, K. F., Su, Y. C., Chu, L. C., Su, S. C., Chiu, H. W., Wong, C. H., Chen, S. T., Shieh, C. W., Yang, S. S., Chen, Y. M., Chao, L. K. Alkali-soluble polysaccharides of rhizoclonium riparium alga induce il-1 gene expression via protein kinase signaling pathways Journal of Agricultural and Food Chemistry 2006 54:3558-3565 DOI:10.1021/jf060442f PMID:19127725
- Brik, A., Yang, Y. Y., Ficht, S., Wong, C. H. Sugar-assisted glycopeptide ligation Journal of the American Chemical Society 2006 128:5626-5627 DOI:10.1021/ja061165w PMID:16637616
- Brigl, M., van den Elzen, P., Chen, X., Meyers, J. H., Wu, D., Wong, C. H., Reddington, F., Illarianov, P. A., Besra, G. S., Brenner, M. B., Gumperz, J. E. Conserved and heterogeneous lipid antigen specificities of CD1d-restricted NKT cell receptors Journal of Immunology 2006 176:3625-3634 PMID:16517731
- Wu, D., Zajonc, D. M., Fujio, M., Sullivan, B. A., Kinjo, Y., Kronenberg, M., Wilson, I. A., Wong, C. H. Design of natural killer T cell activators: structure and function of a microbial glycosphingolipid bound to mouse CD1d Proceedings of the National Academy of Sciences of the United States of America 2006 103:3972-3977 DOI:10.1073/pnas.0600285103 PMID:16537470 PMCID:PMC1449630
- Liu, L., Hong, Z. Y., Wong, C. H. Convergent glycopeptide synthesis by traceless staudinger ligation and enzymatic coupling ChemBioChem 2006 7:429-432 DOI:10.1002/cbic.200500437 PMID:16444769
- Wu, C. Y., King, K. Y., Kuo, C. J., Fang, J. M., Wu, Y. T., Ho, M. Y., Liao, C. L., Shie, J. J., Liang, P. H., Wong, C. H. Stable benzotriazole esters as mechanism-based inactivators of the severe acute respiratory syndrome 3cl protease Chemistry & Biology 2006 13:261-268 DOI:10.1016/j.chembiol.2005.12.008 PMID:16638531
- Chuang, M. H., Wu, M. S., Lo, W. L., Lin, J. T., Wong, C. H., Chiou, S. H. The antioxidant protein alkylhydroperoxide reductase of heliclobacter pylori switches from a peroxide reductase to a molecular chaperone function Proceedings of the National Academy of Sciences of the United States of America 2006 103:2552-2557 DOI:10.1073/pnas.0510770103 PMID:16481626 PMCID:PMC1413804
- Liang, F. S., Brik, A., Lin, Y. C., Elder, J. H., Wong, C. H. Epoxide opening in water and screening in situ for rapid discovery of enzyme inhibitors in microtiter plates Bioorganic & Medicinal Chemistry 2006 14:1058-1062 DOI:10.1016/j.bmc.2005.09.026 PMID:16275107
- Chow, H. F., Ng, K. F., Wang, Z. Y., Wong, C. H., Luk, T., Lo, C. M., Yang, Y. Y. Synthesis of new amphiphilic dendrons bearing aliphatic hydrocarbon surface sectors and a monocarboxylic or dicarboxylic acid focal point Organic Letters 2006 8:471-474 DOI:10.1021/ol0526928 PMID:16435862
- Huang, C. Y., Thayer, D. A., Chang, A. Y., Best, M. D., Hoffmann, J., Head, S., Wong, C. H. Carbohydrate microarray for profiling the antibodies interacting with globo h tumor antigen Proceedings of the National Academy of Sciences of the United States of America 2006 103:15-20 DOI:10.1073/pnas.0509693102 PMID:16373501 PMCID:PMC1325001
- Liu, L., Bennett, C. S., Wong, C. H. Advances in glycoprotein synthesis Chemical Communications 2006 21-33 DOI:10.1039/b513165k
- Whalen, L. J., Wong, C. H. Enzymes in organic synthesis: Aldolase-mediated synthesis of iminocyclitols and novel heterocycles Aldrichimica Acta 2006 39:63-71
- Brik, A., Wu, C. Y., Wong, C. H. Microtiter plate based chemistry and in situ screening: A useful approach for rapid inhibitor discovery Organic & Biomolecular Chemistry 2006 4:1446-1457 DOI:10.1039/b600055j PMID:16604207
- Liang, P. H., Cheng, W. C., Lee, Y. L., Yu, H. P., Wu, Y. T., Lin, Y. L., Wong, C. H. Novel five-membered iminocyclitol derivatives as selective and potent glycosidase inhibitors: New structures for antivirals and osteoarthritis ChemBioChem 2006 7:165-173 DOI:10.1002/cbic.200500321 PMID:16397876
- Lee, J. C., Greenberg, W. A., Wong, C. H. Programmable reactivity-based one-pot oligosaccharide synthesis Nature Protocols 2006 1:3143-3152 DOI:10.1038/nprot.2006.489 PMID:17406577
- Lee, J. C., Wit, C. Y., Apon, J. V., Siuzdak, G., Wong, C. H. Reactivity-based one-pot synthesis of the tumor-associated antigen n3 minor octasaccharide for the development of a photocleavable dios-ms sugar array Angewandte Chemie-International Edition 2006 45:2753-2757 DOI:10.1002/anie.200504067 PMID:16548041
- Hong, Z. Y., Liu, L., Hsu, C. C., Wong, C. H. Three-step synthesis of sialic acids and derivatives Angewandte Chemie-International Edition 2006 45:7417-7421 DOI:10.1002/anie.200601555 PMID:17031889
- Zajonc, D. M., Maricic, I., Wu, D., Halder, R., Roy, K., Wong, C. H., Kumar, V., Wilson, I. A. Structural basis for CD1d presentation of a sulfatide derived from myelin and its implications for autoimmunity Journal of Experimental Medicine 2005 202:1517-1526 DOI:10.1084/jem.20051625 PMID:16314439 PMCID:PMC2213337
- Wei, S. H., Rosen, H., Matheu, M. P., Sanna, M. G., Wang, S. K., Jo, E. J., Wong, C. H., Parker, I., Cahalan, M. D. Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary t cells to lymphatic sinuses Nature Immunology 2005 6:1228-1235 DOI:10.1038/ni1269 PMID:16273098
- Wu, C. Y., Brik, A., Wang, S. K., Chen, Y. H., Wong, C. H. Tetrabutylammonium fluoride-mediated rapid alkylation reaction in microtiter plates for the discovery of enzyme inhibitors in situ ChemBioChem 2005 6:2176-2180 DOI:10.1002/cbic.200500295 PMID:16270365
- Sawkar, A. R., Adamski-Werner, S. L., Cheng, W. C., Wong, C. H., Beutler, E., Zimmer, K. P., Kelly, J. W. Gaucher disease-associated glucocerebrosidases show mutation-dependent chemical chaperoning profiles Chemistry & Biology 2005 12:1235-1244 DOI:10.1016/j.chembiol.2005.09.007 PMID:16298303
- Calarese, D. A., Lee, H. K., Huang, C. Y., Best, M. D., Astronomo, R. D., Stanfield, R. L., Katinger, H., Burton, D. R., Wong, C. H., Wilson, I. A. Dissection of the carbohydrate specificity of the broadly neutralizing-anti-hiv-1 antibody 2g12 Proceedings of the National Academy of Sciences of the United States of America 2005 102:13372-13377 DOI:10.1073/pnas.0505763102 PMID:16174734 PMCID:PMC1224641
- Shie, J. J., Fang, J. M., Kuo, T. H., Kuo, C. J., Liang, P. H., Huang, H. J., Wu, Y. T., Jan, J. T., Cheng, Y. S. E., Wong, C. H. Inhibition of the severe acute respiratory syndrome 3cl protease by peptidomimetic alpha,beta-unsaturated esters Bioorganic & Medicinal Chemistry 2005 13:5240-5252 DOI:10.1016/j.bmc.2005.05.065 PMID:15994085
- Brik, A., Wu, C. Y., Best, M. D., Wong, C. H. Tetrabutylammonium fluoride-assisted rapid n-9-alkylation on purine ring: Application to combinatorial reactions in microtiter plates for the discovery of potent sulfotransferase inhibitors in situ Bioorganic & Medicinal Chemistry 2005 13:4622-4626 DOI:10.1016/j.bmc.2005.02.066 PMID:15953729
- Brik, A., Alexandratos, J., Lin, Y. C., Elder, J. H., Olson, A. J., Wlodawer, A., Goodsell, D. S., Wong, C. H. 1,2,3-triazole as a peptide surrogate in the rapid synthesis of HIV-1 protease inhibitors ChemBioChem 2005 6:1167-1169 DOI:10.1002/cbic.200500101 PMID:15934050
- Shie, J. J., Fang, J. M., Kuo, C. J., Kuo, T. H., Liang, P. H., Huang, H. J., Yang, W. B., Lin, C. H., Chen, J. L., Wu, Y. T., Wong, C. H. Discovery of potent anilide inhibitors against the severe acute respiratory syndrome 3CL protease Journal of Medicinal Chemistry 2005 48:4469-4473 DOI:10.1021/jm050184y PMID:15974598
- Hsu, C. C., Hong, Z. Y., Wada, M., Franke, D., Wong, C. H. Directed evolution of d-sialic acid aldolase to l-3-deoxy-manno-2-octulosonic acid (l-kdo) aldolase Proceedings of the National Academy of Sciences of the United States of America 2005 102:9122-9126 DOI:10.1073/pnas.0504033102 PMID:15967977 PMCID:PMC1166642
- Numa, M. M. D., Lee, L. V., Hsu, C. C., Bower, K. E., Wong, C. H. Identification of novel anthrax lethal factor inhibitors generated by combinatorial pictet-spengler reaction followed by screening in situ ChemBioChem 2005 6:1002-1006 DOI:10.1002/cbic.20050000 PMID:15880659
- Wong, C. H. Protein glycosylation: New challenges and opportunities Journal of Organic Chemistry 2005 70:4219-4225 DOI:10.1021/jo050278f PMID:15903293
- Xing, G. W., Wu, D., Poles, M. A., Horowitz, A., Tsuji, M., Ho, D. D., Wong, C. H. Synthesis and human NKT cell stimulating properties of 3-O-sulfo-α/β-galactosylceramides Bioorganic & Medicinal Chemistry 2005 13:2907-2916 DOI:10.1016/j.bmc.2005.02.018 PMID:15781400
- Kinjo, Y., Wu, D., Kim, G. S., Xing, G. W., Poles, M. A., Ho, D. D., Tsuji, M., Kawahara, K., Wong, C. H., Kronenberg, M. Recognition of bacterial glycosphingolipids by natural killer T cells Nature 2005 434:520-525 DOI:10.1038/nature03407 PMID:15791257
- Sinchaikul, S., Pan, F. M., Cheng, C. W., Wong, C. H., Fang, J. M., Tseng, M. J., Chen, S. T. Protein microarray using alpha-amino acids as metal tags on chips Bioorganic & Medicinal Chemistry Letters 2005 15:1413-1416 DOI:10.1016/j.bmcl.2005.01.001 PMID:15713398
- Fan, G. T., Pan, Y. S., Lu, K. C., Cheng, Y. P., Lin, W. C., Lin, S., Lin, C. H., Wong, C. H., Fang, J. M., Lin, C. C. Synthesis of α-galactosyl ceramide and the related glycolipids for evaluation of their activities on mouse splenocytes Tetrahedron 2005 61:1855-1862 DOI:10.1016/j.tet.2004.12.027
- Tolbert, T. J., Franke, D., Wong, C. H. A new strategy for glycoprotein synthesis: ligation of synthetic glycopeptides with truncated proteins expressed in E. coli as TEV protease cleavable fusion protein Bioorganic & Medicinal Chemistry 2005 13:909-915 DOI:10.1016/j.bmc.2004.06.047 PMID:15653356
- Wu, D., Xing, G. W., Poles, M. A., Horowitz, A., Kinjo, Y., Sullivan, B., Bodmer-Narkevitch, V., Plettenburg, O., Kronenberg, M., Tsuji, M., Ho, D. D., Wong, C. H. Bacterial glycolipids and analogs as antigens for CD1d-restricted NKT cells Proceedings of the National Academy of Sciences of the United States of America 2005 102:1351-1356 DOI:10.1073/pnas.0408696102 PMID:15665086 PMCID:PMC547854
- Thayer, D. A., Yu, H. N., Galan, M. C., Wong, C. H. A general strategy toward s-linked glycopeptides Angewandte Chemie-International Edition 2005 44:4596-4599 DOI:10.1002/anie.200500090 PMID:15991213
- Scanlan, C., Lee, H. K., Blixt, O., Wong, C. H., Wilson, I., Burton, D., Dwek, R., Rudd, P. Antibody recognition of a carbohydrate epitope: a template for HIV vaccine design Advances in Experimental Medicine and Biology 2005 564:7-8 DOI:10.1007/0-387-25515-X_4 PMID:16400800
- Fridman, M., Belakhov, V., Lee, L. V., Liang, F. S., Wong, C. H., Baasov, T. Dual effect of synthetic aminoglycosides: Antibacterial activity against bacillus anthracis and inhibition of anthrax lethal factor Angewandte Chemie-International Edition 2005 44:447-452 DOI:10.1002/anie.200462003 PMID:15624157
- Mocharla, V. P., Colasson, B., Lee, L. V., Roper, S., Sharpless, K. B., Wong, C. H., Kolb, H. C. In situ click chemistry: Enzyme-generated inhibitors of carbonic anhydrase ii Angewandte Chemie-International Edition 2005 44:116-120 DOI:10.1002/anie.200461580
- Nyffeler, P. T., Duron, S. G., Burkart, M. D., Vincent, S. P., Wong, C. H. Selectfluor: Mechanistic insight and applications Angewandte Chemie-International Edition 2005 44:192-212 DOI:10.1002/anie.200400648
- Chen, J. H., Chang, Y. W., Yao, C. W., Chiueh, T. S., Huang, S. C., Chien, K. Y., Chen, A., Chang, F. Y., Wong, C. H., Chen, Y. J. Plasma proteome of severe acute respiratory syndrome analyzed by two-dimensional gel electrophoresis and mass spectrometry Proceedings of the National Academy of Sciences of the United States of America 2004 101:17039-17044 DOI:10.1073/pnas.0407992101 PMID:15572443 PMCID:PMC535397
- Blixt, O., Head, S., Mondala, T., Scanlan, C., Huflejt, M. E., Alvarez, R., Bryan, M. C., Fazio, F., Calarese, D., Stevens, J., Razi, N., Stevens, D. J., et al. Printed covalent glycan array for ligand profiling of diverse glycan binding proteins Proceedings of the National Academy of Sciences of the United States of America 2004 101:17033-17038 DOI:10.1073/pnas.0407902101 PMID:15563589 PMCID:PMC534418
- Hanson, S., Best, M., Bryan, M. C., Wong, C. H. Chemoenzymatic synthesis of oligosaccharides and glycoproteins Trends in Biochemical Sciences 2004 29:656-663 DOI:10.1016/j.tibs.2004.10.004 PMID:15544952
- Lin, H., Thayer, D. A., Wong, C. H., Walsh, C. T. Macrolactamization of glycosylated peptide thioesters by the thioesterase domain of tyrocidine synthetase Chemistry & Biology 2004 11:1635-1642 DOI:10.1016/j.chembiol.2004.09.015 PMID:15610847
- Hsu, H. Y., Hua, K. F., Lin, C. C., Lin, C. H., Hsu, J., Wong, C. H. Extract of Reishi polysaccharides induces cytokine expression via TLR4-modulated protein kinase signaling pathways Journal of Immunology 2004 173:5989-5999 PMID:15528333
- Chien, C. A., Cheng, J. L., Chang, W. T., Tien, M. H., Tsao, C. M., Chang, Y. H., Chang, H. Y., Hsieh, J. F., Wong, C. H., Chen, S. T. Polysaccharides of ganoderma lucidum alter cell immunophenotypic expression and enhance cd56(+) nk-cell cytotoxicity in cord blood Bioorganic & Medicinal Chemistry 2004 12:5603-5609 DOI:10.1016/j.bmc.2004.08.004 PMID:15465338
- Chen, H. S., Tsai, Y. F., Lin, S., Lin, C. C., Khoo, K. H., Lin, C. H., Wong, C. H. Studies on the immuno-modulating and anti-tumor activities of Ganoderma lucidum (Reishi) polysaccharides Bioorganic & Medicinal Chemistry 2004 12:5595-5601 DOI:10.1016/j.bmc.2004.08.003 PMID:15465337
- Heine, A., Luz, J. G., Wong, C. H., Wilson, I. A. Analysis of the class i aldolase binding site architecture based on the crystal structure of 2-deoxyribose-5-phosphate aldolase at 0.99 Å resolution Journal of Molecular Biology 2004 343:1019-1034 DOI:10.1016/j.jmb.2004.08.066 PMID:15476818
- Liu, J., Numa, M. M. D., Liu, H. T., Huang, S. J., Sears, P., Shikhman, A. R., Wong, C. H. Synthesis and high-throughput screening of N-acetyl-β-hexosaminidase inhibitor libraries targeting osteoarthritis Journal of Organic Chemistry 2004 69:6273-6283 DOI:10.1021/jo049355h PMID:15357586
- Bryan, M. C., Fazio, F., Lee, H. K., Huang, C. Y., Chang, A., Best, M. D., Calarese, D. A., Blixt, C., Paulson, J. C., Burton, D., Wilson, I. A., Wong, C. H. Covalent display of oligosaccharide arrays in microtiter plates Journal of the American Chemical Society 2004 126:8640-8641 DOI:10.1021/ja048433f PMID:15250702
- Wu, C. Y., Jan, J. T., Ma, S. H., Kuo, C. J., Juan, H. F., Cheng, Y. S. E., Hsu, H. H., Huang, H. C., Wu, D., Brik, A., Liang, F. S., Liu, R. S., et al. Small molecules targeting severe acute respiratory syndrome human coronavirus Proceedings of the National Academy of Sciences of the United States of America 2004 101:10012-10017 DOI:10.1073/pnas.0403596101 PMID:15226499 PMCID:PMC454157
- Cheng, T. J., Brik, A., Wong, C. H., Kan, C. C. Model system for high-throughput screening of novel human immunodeficiency virus protease inhibitors in escherichia coli Antimicrobial Agents and Chemotherapy 2004 48:2437-2447 DOI:10.1128/aac.48.7.2437-2447.2004 PMID:15215092
- Bryan, M. C., Lee, L. V., Wong, C. H. High-throughput identification of fucosyltransferase inhibitors using carbohydrate microarrays Bioorganic & Medicinal Chemistry Letters 2004 14:3185-3188 DOI:10.1016/j.bmcl.2004.04.001 PMID:15149672
- Best, M. D., Brik, A., Chapman, E., Lee, L. V., Cheng, W. C., Wong, C. H. Rapid discovery of potent sulfotransferase inhibitors by diversity-oriented reaction in microplates followed by in situ screening ChemBioChem 2004 5:811-819 DOI:10.1002/cbic.200300841 PMID:15174164
- Klostermeier, D., Sears, P., Wong, C. H., Millar, D. P., Williamson, J. R. A three-fluorophore FRET assay for high-throughput screening of small-molecule inhibitors of ribosome assembly Nucleic Acids Research 2004 32:2707-2715 DOI:10.1093/nar/gkh588 PMID:15148358 PMCID:PMC419595
- Bryan, M. C., Wong, C. H. Aminoglycoside array for the high-throughput analysis of small molecule-rna interactions Tetrahedron Letters 2004 45:3639-3642 DOI:10.1016/j.tetlet.2004.03.035
- Lee, L. V., Bower, K. E., Liang, F. S., Shi, J., Wu, D., Sucheck, S. J., Vogt, P. K., Wong, C. H. Inhibition of the proteolytic activity of anthrax lethal factor by aminoglycosides Journal of the American Chemical Society 2004 126:4774-4775 DOI:10.1021/ja0495359 PMID:15080670
- Cheng, C. W., Lin, K. C., Pan, F. M., Sinchaikul, S., Wong, C. H., Su, W. C., Hsu, C. H., Chen, S. T. Facile synthesis of metal-chelating peptides on chip for protein array Bioorganic & Medicinal Chemistry Letters 2004 14:1987-1990 DOI:10.1016/j.bmcl.2004.01.084 PMID:15050643
- Fazio, F., Bryan, M. C., Lee, H. K., Chang, A., Wong, C. H. Assembly of sugars on polystyrene plates: A new facile microarray fabrication technique Tetrahedron Letters 2004 45:2689-2692 DOI:10.1016/j.tetlet.2004.01.159
- Liu, J., Hsu, C. C., Wong, C. H. Sequential aldol condensation catalyzed by dera mutant ser238asp and a formal total synthesis of atorvastatin Tetrahedron Letters 2004 45:2439-2441 DOI:10.1016/j.teltet.2004.01.110
- Duron, S. G., Polat, T., Wong, C. H. N-(phenylthio)-epsilon-caprolactam: A new promoter for the activation of thioglycosides Organic Letters 2004 6:839-841 DOI:10.1021/ol0400084 PMID:14986988
- Yu, H. N., Furukawa, J., Ikeda, T., Wong, C. H. Novel efficient routes to heparin monosaccharides and disaccharides achieved via regio- and stereoselective glycosidation Organic Letters 2004 6:723-726 DOI:10.1021/ol036390m PMID:14986959
- Heck, M. P., Vincent, S. P., Murray, B. W., Bellamy, F., Wong, C. H., Mioskowski, C. Cyclic amidine sugars as transition-state analogue inhibitors of glycosidases: Potent competitive inhibitors of mannosidases Journal of the American Chemical Society 2004 126:1971-1979 DOI:10.1021/ja037822r PMID:14971930
- Chou, C. H., Wu, C. S., Chen, C. H., Lu, L. D., Kulkarni, S. S., Wong, C. H., Hung, S. C. Regioselective glycosylation of neamine core: A facile entry to kanamycin b related analogues Organic Letters 2004 6:585-588 DOI:10.1021/ol0363927 PMID:14961629
- Zhang, Z. W., Gildersleeve, J., Yang, Y. Y., Xu, R., Loo, J. A., Uryu, S., Wong, C. H., Schultz, P. G. A new strategy for the synthesis of glycoproteins Science 2004 303:371-373 DOI:10.1126/science.1089509 PMID:14726590
- Nyffeler, P. T., Boyle, N. A., Eltepu, L., Wong, C. H., Eschenmoser, A., Lerner, R. A., Wentworth, P. Dihydrogen trioxide (hoooh) is generated during the thermal reaction between hydrogen peroxide and ozone Angewandte Chemie-International Edition 2004 43:4656-4659 DOI:10.1002/anie.200460457 PMID:15317003
- Agnelli, T., Sucheck, S. J., Marby, K. A., Rabuka, D., Yao, S. L., Sears, P. S., Liang, F. S., Wong, C. H. Dimeric aminoglycosides as antibiotics Angewandte Chemie-International Edition 2004 43:1562-1566 DOI:10.1002/anie.200353225 PMID:15022234
- Chang, C. F., Ho, C. W., Wu, C. Y., Chao, T. A., Wong, C. H., Lin, C. H. Discovery of picomolar slow tight-binding inhibitors of α-fucosidase Chemistry & Biology 2004 11:1301-1306 DOI:10.1016/j.chembiol.2004.07.009 PMID:15380190
- Lee, H. K., Scanlan, C. N., Huang, C. Y., Chang, A. Y., Calarese, D. A., Dwek, R. A., Rudd, P. M., Burton, D. R., Wilson, I. A., Wong, C. H. Reactivity-based one-pot synthesis of oligomannoses: Defining antigens recognized by 2g12, a broadly neutralizing anti-hiv-1 antibody Angewandte Chemie-International Edition 2004 43:1000-1003 DOI:10.1002/anie.200353105 PMID:14966891
- Hanson, S. R., Best, M. D., Wong, C. H. Sulfatases: Structure, mechanism, biological activity, inhibition, and synthetic utility Angewandte Chemie-International Edition 2004 43:5736-5763 DOI:10.1002/anie.200300632 PMID:15493058
- Chapman, E., Best, M. D., Wong, C. H., Hanson, S. R. Sulfotransferases: Structure, mechanism, biological activity, inhibition, and synthetic utility Angewandte Chemie-International Edition 2004 43:3526-3548 DOI:10.1002/anie.200300631 PMID:15293241
- Liang, F. S., Wang, S. K., Nakatani, T., Wong, C. H. Targeting RNAs with tobramycin analogues Angewandte Chemie-International Edition 2004 43:6496-6500 DOI:10.1002/anie.200460558 PMID:15578772
- Fazio, F., Wong, C. H. Rucl3-promoted amide formation from azides and thioacids Tetrahedron Letters 2003 44:9083-9085 DOI:10.1016/j.tetlet.2003.10.054
- Brik, A., Muldoon, J., Lin, Y. C., Elder, J. H., Goodsell, D. S., Olson, A. J., Fokin, V. V., Sharpless, K. B., Wong, C. H. Rapid diversity-oriented synthesis in microtiter plates for in situ screening of HIV protease inhibitors ChemBioChem 2003 4:1246-1248 DOI:10.1002/cbic.200300724 PMID:14613121
- Feizi, T., Fazio, F., Chai, W. C., Wong, C. H. Carbohydrate microarrays - a new set of technologies at the frontiers of glycomics Current Opinion in Structural Biology 2003 13:637-645 DOI:10.1016/j.sbi.2003.09.002 PMID:14568620
- Franke, D., Machajewski, T., Hsu, C. C., Wong, C. H. One-pot synthesis of l-fructose using coupled multienzyme systems based on rhamnulose-1-phosphate aldolase Journal of Organic Chemistry 2003 68:6828-6831 DOI:10.1021/jo030021m PMID:12919060
- Lee, L. V., Mitchell, M. L., Huang, S. J., Fokin, V. V., Sharpless, K. B., Wong, C. H. A potent and highly selective inhibitor of human α-1,3-fucosyltransferase via click chemistry Journal of the American Chemical Society 2003 125:9588-9589 DOI:10.1021/ja0302836 PMID:12904015
- Liu, H., Ritter, T. K., Sadamoto, R., Sears, P. S., Wu, M., Wong, C. H. Acceptor specificity and inhibition of the bacterial cell-wall glycosyltransferase murg ChemBioChem 2003 4:603-609 DOI:10.1002/cbic.200300557 PMID:12851929
- Mak, C. C., Brik, A., Lerner, D. L., Elder, J. H., Morris, G. M., Olson, A. J., Wong, C. H. Design and synthesis of broad-based mono- and bi-cyclic inhibitors of FIV and HIV proteases Bioorganic & Medicinal Chemistry 2003 11:2025-2040 DOI:10.1016/s0968-0896(03)00054-3 PMID:12670654
- Wada, M., Hsu, C. C., Franke, D., Mitchell, M., Heine, A., Wilson, I., Wong, C. H. Directed evolution of N-acetylneuraminic acid aldolase to catalyze enantiomeric aldol reactions Bioorganic & Medicinal Chemistry 2003 11:2091-2098 DOI:10.1016/s0968-0896(03)00052-x PMID:12670660
- Mong, T. K. K., Huang, C. Y., Wong, C. H. A new reactivity-based one-pot synthesis of n-acetyllactosamine oligomers Journal of Organic Chemistry 2003 68:2135-2142 DOI:10.1021/jo0206420 PMID:12636372
- Liu, H. T., Wang, L., Brock, A., Wong, C. H., Schultz, P. G. A method for the generation of glycoprotein mimetics Journal of the American Chemical Society 2003 125:1702-1703 DOI:10.1021/ja029433n PMID:12580587
- Chapman, E., Bryan, M. C., Wong, C. H. Mechanistic studies of beta-arylsulfotransferase iv Proceedings of the National Academy of Sciences of the United States of America 2003 100:910-915 DOI:10.1073/pnas.0337638100 PMID:12547913 PMCID:PMC298700
- Mong, T. K. K., Lee, H. K., Duron, S. G., Wong, C. H. Reactivity-based one-pot total synthesis of fucose gm(1) oligosaccharide: A sialylated antigenic epitope of small-cell lung cancer Proceedings of the National Academy of Sciences of the United States of America 2003 100:797-802 DOI:10.1073/pnas.0337590100 PMID:12552090 PMCID:PMC298681
- Wong, C. H., Bryan, M. C., Nyffeler, P. T., Liu, H. T., Chapman, E. Synthesis of carbohydrate-based antibiotics Pure and Applied Chemistry 2003 75:179-186 DOI:10.1351/pac200375020179
- Brik, A., Wong, C. H. HIV-1 protease: Mechanism and drug discovery Organic & Biomolecular Chemistry 2003 1:5-14 DOI:10.1039/b208248a PMID:12929379
- DeSantis, G., Liu, J., Clark, D. P., Heine, A., Wilson, I. A., Wong, C. H. Structure-based mutagenesis approaches toward expanding the substrate specificity of d-2-deoxyribose-5-phosphate aldolase Bioorganic & Medicinal Chemistry 2003 11:43-52 DOI:10.1016/s0968-0896(02)00429-7 PMID:12467706
- Ritter, T. K., Mong, K. K. T., Liu, H. T., Nakatani, T., Wong, C. H. A programmable one-pot oligosaccharide synthesis for diversifying the sugar domains of natural products: A case study of vancomycin Angewandte Chemie-International Edition 2003 42:4657-4660 DOI:10.1002/anie.200351534 PMID:14533156
- Silvestri, M. G., Desantis, G., Mitchell, M., Wong, C. H. Asymmetric aldol reactions using aldolases Topics in Stereochemistry 2003 23:267-342
- Wu, C. Y., Chang, C. F., Chen, J. S. Y., Wong, C. H., Lin, C. H. Rapid diversity-oriented synthesis in microtiter plates for in situ screening: Discovery of potent and selective α-fucosidase inhibitors Angewandte Chemie-International Edition 2003 42:4661-4664 DOI:10.1002/anie.200351823 PMID:14533157
- Wong, C. H., Bryan, M. C. Sugar arrays in microtiter plates Recognition of Carbohydrates in Biological Systems Pt A: General Procedures 2003 362:218-225 PMID:12968366
- Wong, C. H., Liang, F. S. Surface plasmon resonance study of RNA-aminoglycoside interactions Recognition of Carbohydrates in Biological Systems Pt A: General Procedures 2003 362:340-353 PMID:12968375
- Chapman, E., Ding, S., Schultz, P. G., Wong, C. H. A potent and highly selective sulfotransferase inhibitor Journal of the American Chemical Society 2002 124:14524-14525 DOI:10.1021/ja021086u PMID:12465948
- Fazio, F., Bryan, M. C., Blixt, O., Paulson, J. C., Wong, C. H. Synthesis of sugar arrays in microtiter plate Journal of the American Chemical Society 2002 124:14397-14402 DOI:10.1021/ja020887u PMID:12452714
- Sawkar, A. R., Cheng, W. C., Beutler, E., Wong, C. H., Balch, W. E., Kelly, J. W. Chemical chaperones increase the cellular activity of N370S beta-glucosidase: a therapeutic strategy for Gaucher disease Proceedings of the National Academy of Sciences of the United States of America 2002 99:15428-15433 DOI:10.1073/pnas.192582899 PMID:12434014 PMCID:PMC137733
- Nyffeler, P. T., Liang, C. H., Koeller, K. M., Wong, C. H. The chemistry of amine-azide interconversion: Catalytic diazotransfer and regioselective azide reduction Journal of the American Chemical Society 2002 124:10773-10778 DOI:10.1021/ja0264605 PMID:12207533
- Sadamoto, R., Niikura, K., Sears, P. S., Liu, H. T., Wong, C. H., Suksomcheep, A., Tomita, F., Monde, K., Nishimura, S. I. Cell-wall engineering of living bacteria Journal of the American Chemical Society 2002 124:9018-9019 DOI:10.1021/ja026133x PMID:12148983
- Zhang, Z. Y., Wong, C. H. Regioselective benzoylation of sugars mediated by excessive bu2sno: Observation of temperature promoted migration Tetrahedron 2002 58:6513-6519 DOI:10.1016/s0040-4020(02)00661-0
- Mitchell, M. L., Lee, L. V., Wong, C. H. Synthesis and evaluation of six-membered GDP-iminocyclitol Tetrahedron Letters 2002 43:5691-5693 DOI:10.1016/s0040-4039(02)01108-5
- Brik, A., Lin, Y. C., Elder, J., Wong, C. H. A quick diversity-oriented amide-forming reaction to optimize p-subsite residues of hiv protease inhibitors Chemistry & Biology 2002 9:891-896 DOI:10.1016/s1074-5521(02)00184-9 PMID:12204688
- Zhang, Z. Y., Niikura, K., Huang, X. F., Wong, C. H. A strategy for the one-pot synthesis of sialylated oligosaccharides Canadian Journal of Chemistry-Revue Canadienne De Chimie 2002 80:1051-1054 DOI:10.1139/v02-131
- Thunnissen, Mmgm, Andersson, B., Samuelsson, B., Wong, C. H., Haeggstrom, J. Z. Crystal structures of leukotriene a(4) hydrolase in complex with captopril and two competitive tight-binding inhibitors FASEB Journal 2002 16:1648-1650 DOI:10.1096/fj.01-1017fje PMID:12207002
- Plettenburg, O., Mui, C., Bodmer-Narkevitch, V., Wong, C. H. Rapid preparation of glycolipid libraries by cross metathesis Advanced Synthesis & Catalysis 2002 344:622-626 DOI:10.1002/1615-4169(200208)344:6/7<622::aid-adsc622>3.0.co;2-w
- Plettenburg, O., Bodmer-Narkevitch, V., Wong, C. H. Synthesis of alpha-galactosyl ceramide, a potent immunostimulatory agent Journal of Organic Chemistry 2002 67:4559-4564 DOI:10.1021/jo0201530 PMID:12076157
- Bryan, M. C., Plettenburg, O., Sears, P., Rabuka, D., Wacowich-Sgarbi, S., Wong, C. H. Saccharide display on microtiter plates Chemistry & Biology 2002 9:713-720 DOI:10.1016/s1074-5521(02)00155-2 PMID:12079783
- Liu, J., DeSantis, G., Wong, C. H. Structure-based rationalization of aldolase-catalyzed asymmetric synthesis Canadian Journal of Chemistry-Revue Canadienne De Chimie 2002 80:643-645 DOI:10.1139/v02-094
- Liu, J., Wong, C. H. An efficient method for the cleavage of p-methoxybenzylidene (PMP), tetrahydropyranyl (THP) and 1,3-dithiane protecting groups by Selectfluor™ Tetrahedron Letters 2002 43:4037-4039 DOI:10.1016/s0040-4039(02)00740-2
- Liu, J., Wong, C. H. Selectfluor ™-mediated allylstannation of aldehydes and imines Tetrahedron Letters 2002 43:3915-3917 DOI:10.1016/s0040-4039(02)00640-8
- Liu, J., Huang, C. Y., Wong, C. H. An efficient method for the preparation of 2-hydroxy- and 2-aminoglycals from glycosyl sulfoxides Tetrahedron Letters 2002 43:3447-3448 DOI:10.1016/s0040-4039(02)00555-5
- Kanemitsu, T., Wong, C. H., Kanie, O. Solid-phase synthesis of oligosaccharides and on-resin quantitative monitoring using gated decoupling c-13 NMR Journal of the American Chemical Society 2002 124:3591-3599 DOI:10.1021/ja0167396 PMID:11929248
- Wang, Y. Y., Khoo, K. H., Chen, S. T., Lin, C. C., Wong, C. H., Lin, C. H. Studies on the immuno-modulating and antitumor activities of Ganoderma lucidum (Reishi) polysaccharides: functional and proteomic analyses of a fucose-containing glycoprotein fraction responsible for the activities Bioorganic & Medicinal Chemistry 2002 10:1057-1062 DOI:10.1016/s0968-0896(01)00377-7 PMID:11836115
- Chapman, E., Wong, C. H. A ph sensitive colorometric assay for the high-throughput screening of enzyme inhibitors and substrates: A case study using kinases Bioorganic & Medicinal Chemistry 2002 10:551-555 DOI:10.1016/s0968-0896(01)00306-6 PMID:11814841
- Guo, C. T., Sun, X. L., Kanie, O., Shortridge, K. F., Suzuki, T., Miyamoto, D., Hidari, Kipj, Wong, C. H., Suzuki, Y. An o-glycoside of sialic acid derivative that inhibits both hemagglutinin and sialidase activities of influenza viruses Glycobiology 2002 12:183-190 DOI:10.1093/glycob/12.3.183 PMID:11971862
- Demura, M., Noda, M., Kajimoto, T., Uchiyama, T., Umemoto, K., Wong, C. H., Asakura, T. Solution structure of sialyl lewis x mimics studied by two-dimensional NMR Journal of Molecular Structure 2002 602:215-222 DOI:10.1016/s0022-2860(01)00678-0
- Liu, J., Wong, C. H. Aldolase-catalyzed asymmetric synthesis of novel pyranose synthons as a new entry to heterocycles and epothilones Angewandte Chemie-International Edition 2002 41:1404-1407 DOI:10.1002/1521-3773(20020415)41:8<1404::aid-anie1404>3.0.co;2-g PMID:19750780
- Wong, C. K., White, H. D., Wilcox, R. G., Criger, D. A., Califf, R. M., Topol, E. J., Ohman, E. M., GUSTO III Investigators Management and outcome of patients with atrial fibrillation during acute myocardial infarction: the GUSTO-III experience. Global use of strategies to open occluded coronary arteries Heart 2002 88:357-362 DOI:10.1136/heart.88.4.357 PMID:12231591 PMCID:PMC1767360
- Tolbert, T. J., Wong, C. H. New methods for proteomic research: Preparation of proteins with n-terminal cysteines for labeling and conjugation Angewandte Chemie-International Edition 2002 41:2171-2174 DOI:10.1002/1521-3773(20020617)41:12<2171::aid-anie2171>3.0.co;2-q PMID:19746634
- Mong, K. K. T., Wong, C. H. Reactivity-based one-pot synthesis of a lewis y carbohydrate hapten: A colon-rectal cancer antigen determinant Angewandte Chemie-International Edition 2002 41:4087-4090 DOI:10.1002/1521-3773(20021104)41:21<4087::aid-anie4087>3.0.co;2-x PMID:12412090
- Mitchell, M. L., Tian, F., Lee, L. V., Wong, C. H. Synthesis and evaluation of transition-state analogue inhibitors of α-1,3-fucosyltransferase Angewandte Chemie-International Edition 2002 41:3041-3044 DOI:10.1002/1521-3773(20020816)41:16<3041::aid-anie3041>3.0.co;2-v PMID:12203452
- Izumi, M., Shen, G. J., Wacowich-Sgarbi, S., Nakatani, T., Plettenburg, O., Wong, C. H. Microbial glycosyltransferases for carbohydrate synthesis: Alpha-2,3-sialyltransferase from neisseria gonorrheae Journal of the American Chemical Society 2001 123:10909-10918 DOI:10.1021/ja011382r PMID:11686694
- Saotome, C., Wong, C. H., Kanie, O. Combinatorial library of five-membered iminocyclitol and the inhibitory activities against glyco-enzymes Chemistry & Biology 2001 8:1061-1070 DOI:10.1016/s1074-5521(01)00074-6 PMID:11731297
- Heine, A., DeSantis, G., Luz, J. G., Mitchell, M., Wong, C. H., Wilson, I. A. Observation of covalent intermediates in an enzyme mechanism at atomic resolution Science 2001 294:369-374 DOI:10.1126/science.1063601 PMID:11598300
- Liu, H. T., Sadamoto, R., Sears, P. S., Wong, C. H. An efficient chemoenzymatic strategy for the synthesis of wild-type and vancomycin-resistant bacterial cell-wall precursors: UDP-N-acetylmuramyl-peptides Journal of the American Chemical Society 2001 123:9916-9917 DOI:10.1021/ja011708w PMID:11583564
- Kozlov, I. A., Mao, S. L., Xu, Y., Huang, X. F., Lee, L., Sears, P. S., Gao, C., Coyle, A. R., Janda, K. D., Wong, C. H. Synthesis of solid-supported mirror-image sugars: A novel method for selecting receptors for cellular-surface carbohydrates ChemBioChem 2001 2:741-746 DOI:10.1002/1439-7633(20011001)2:10<741::aid-cbic741>3.0.co;2-b PMID:11948856
- Buhler, B., Lin, Y. C., Morris, G., Olson, A. J., Wong, C. H., Richman, D. D., Elder, J. H., Torbett, B. E. Viral evolution in response to the broad-based retroviral protease inhibitor TL-3 Journal of Virology 2001 75:9502-9508 DOI:10.1128/jvi.75.19.9502-9508.2001 PMID:11533212 PMCID:PMC114517
- Mitchell, M., Qaio, L., Wong, C. H. Chemical-enzymatic synthesis of iminocyclitol phosphonic acids Advanced Synthesis & Catalysis 2001 343:596-599 DOI:10.1002/1615-4169(200108)343:6/7<596::aid-adsc596>3.0.co;2-v
- Huang, X. F., Witte, K. L., Bergbreiter, D. E., Wong, C. H. Homogenous enzymatic synthesis using a thermo-responsive water-soluble polymer support Advanced Synthesis & Catalysis 2001 343:675-681 DOI:10.1002/1615-4169(200108)343:6/7<675::aid-adsc675>3.0.co;2-2
- Liu, J., Shikhman, A. R., Lotz, M. K., Wong, C. H. Hexosaminidase inhibitors as new drug candidates for the therapy of osteoarthritis Chemistry & Biology 2001 8:701-711 DOI:10.1016/s1074-5521(01)00045-x PMID:11451670
- Izumi, M., Wong, C. H. Microbial sialyltransferases for carbohydrate synthesis Trends in Glycoscience and Glycotechnology 2001 13:345-360
- Le, V. D., Mak, C. C., Lin, Y. C., Elder, J. H., Wong, C. H. Structure-activity studies of fiv and hiv protease inhibitors containing allophenylnorstatine Bioorganic & Medicinal Chemistry 2001 9:1185-1195 DOI:10.1016/s0968-0896(00)00346-1 PMID:11377177
- Sears, P., Wong, C. H. Toward automated synthesis of oligosaccharides and glycoproteins Science 2001 291:2344-2350 DOI:10.1126/science.1058899 PMID:11269314
- Silvestri, M. G., Wong, C. H. Opening of thiiranes: Preparation of orthogonal protected 2-thioglyceraldehyde Journal of Organic Chemistry 2001 66:910-914 DOI:10.1021/jo001392v PMID:11430112
- Mak, C. C., Le, V. D., Lin, Y. C., Elder, J. H., Wong, C. H. Design, synthesis, and biological evaluation of hiv/fiv protease inhibitors incorporating a conformationally constrained macrocycle with a small p3 ' residue Bioorganic & Medicinal Chemistry Letters 2001 11:219-222 DOI:10.1016/s0960-894x(00)00641-7 PMID:11206463
- Ritter, T. K., Wong, C. H. Synthesis of N-acetylglucosamine thiazoline/lipid II hybrids Tetrahedron Letters 2001 42:615-618 DOI:10.1016/s0040-4039(00)02020-7
- Koeller, K. M., Wong, C. H. Enzymes for chemical synthesis Nature 2001 409:232-240 DOI:10.1038/35051706 PMID:11196651
- Ritter, T. K., Wong, C. H. Carbohydrate-based antibiotics: a new approach to tackling the problem of resistance Angewandte Chemie-International Edition 2001 40:3508-3533 DOI:10.1002/1521-3773(20011001)40:19<3508::AID-ANIE3508>3.0.CO;2-I PMID:11592183
- Ye, X. S., Huang, X. F., Wong, C. H. Conversion of the carboxy group of sialic acid donors to a protected hydroxymethyl group yields an efficient reagent for the synthesis of the unnatural beta-linkage Chemical Communications 2001 974-975 DOI:10.1039/b102166b
- Burkhart, F., Zhang, Z. Y., Wacowich-Sgarbi, S., Wong, C. H. Synthesis of the globo h hexasaccharide using the programmable reactivity-based one-pot strategy Angewandte Chemie-International Edition 2001 40:1274-1277 DOI:10.1002/1521-3773(20010401)40:7<1274::aid-anie1274>3.0.co;2-w PMID:11301448
- Yu, C. S., Niikura, K., Lin, C. C., Wong, C. H. The thioglycoside and glycosyl phosphite of 5-azido sialic acid: Excellent donors for the alpha-glycosylation of primary hydroxy groups Angewandte Chemie-International Edition 2001 40:2900-2903 DOI:10.1002/1521-3773(20010803)40:15<2900::aid-anie2900>3.0.co;2-4 PMID:11500903
- Tsai, C. Y., Huang, X. F., Wong, C. H. Design and synthesis of cyclic sialyl lewis x mimetics: A remarkable enhancement of inhibition by pre-organizing all essential functional groups Tetrahedron Letters 2000 41:9499-9503 DOI:10.1016/s0040-4039(00)01653-1
- Romero, A., Wong, C. H. Chemo-enzymatic total synthesis of 3-epiaustraline, australine, and 7-epialexine Journal of Organic Chemistry 2000 65:8264-8268 DOI:10.1021/jo000933d PMID:11101383
- Sucheck, S. J., Wong, C. H. Rna as a target for small molecules Current Opinion in Chemical Biology 2000 4:678-686 DOI:10.1016/s1367-5931(00)00142-3 PMID:11102874
- Koeller, K. M., Wong, C. H. Synthesis of complex carbohydrates and glycoconjugates: Enzyme-based and programmable one-pot strategies Chemical Reviews 2000 100:4465-4493 DOI:10.1021/cr990297n PMID:11749355
- Koeller, K. M., Wong, C. H. Complex carbohydrate synthesis tools for glycobiologists: Enzyme-based approach and programmable one-pot strategies Glycobiology 2000 10:1157-1169 DOI:10.1093/glycob/10.11.1157 PMID:11087708
- Fong, S., Machajewski, T. D., Mak, C. C., Wong, C. H. Directed evolution of d-2-keto-3-deoxy-6-phosphogluconate aldolase to new variants for the efficient synthesis of d- and l-sugars Chemistry & Biology 2000 7:873-883 DOI:10.1016/s1074-5521(00)00035-1 PMID:11094340
- Flessner, T., Wong, C. H. Efficient synthesis of triazoles from d-arabinose and l-fucose Tetrahedron Letters 2000 41:7805-7808 DOI:10.1016/s0040-4039(00)01356-3
- Duffels, A., Green, L. G., Lenz, R., Ley, S. V., Vincent, S. P., Wong, C. H. Chemoenzymatic synthesis of l-galactosylated dimeric sialyl lewis x structures employing alpha-1,3-fucosyltransferase v Bioorganic & Medicinal Chemistry 2000 8:2519-2525 DOI:10.1016/s0968-0896(00)00187-5 PMID:11058047
- Burkart, M. D., Izumi, M., Chapman, E., Lin, C. H., Wong, C. H. Regeneration of PAPS for the enzymatic synthesis of sulfated oligosaccharides Journal of Organic Chemistry 2000 65:5565-5574 DOI:10.1021/jo000266o PMID:10970295
- Burkart, M. D., Vincent, S. P., Duffels, A., Murray, B. W., Ley, S. V., Wong, C. H. Chemo-enzymatic synthesis of fluorinated sugar nucleotide: Useful mechanistic probes for glycosyltransferases Bioorganic & Medicinal Chemistry 2000 8:1937-1946 DOI:10.1016/s0968-0896(00)00139-5 PMID:11003139
- Koeller, K. M., Wong, C. H. Emerging themes in medicinal glycoscience Nature Biotechnology 2000 18:835-841 PMID:10932151
- Vincent, S. P., Schleyer, A., Wong, C. H. Asymmetric strecker synthesis of c-glycopeptide Journal of Organic Chemistry 2000 65:4440-4443 DOI:10.1021/jo000034p PMID:10891150
- Sun, X. L., Kanie, Y., Guo, C. T., Kanie, O., Suzuki, Y., Wong, C. H. Syntheses of c-3-modified sialylglycosides as selective inhibitors of influenza hemagglutinin and neuraminidase European Journal of Organic Chemistry 2000 2643-2653
- Takayanagi, M., Flessner, T., Wong, C. H. A strategy for the solution-phase parallel synthesis of n-(pyrrolidinylmethyl)hydroxamic acids Journal of Organic Chemistry 2000 65:3811-3815 DOI:10.1021/jo000186k PMID:10864769
- Tolbert, T. J., Wong, C. H. Intein-mediated synthesis of proteins containing carbohydrates and other molecular probes Journal of the American Chemical Society 2000 122:5421-5428 DOI:10.1021/ja0000192
- Sucheck, S. J., Wong, A. L., Koeller, K. M., Boehr, D. D., Draker, K., Sears, P., Wright, G. D., Wong, C. H. Design of bifunctional antibiotics that target bacterial rRNA and inhibit resistance-causing enzymes Journal of the American Chemical Society 2000 122:5230-5231 DOI:10.1021/ja000575w
- Koeller, K. M., Smith, M. E. B., Huang, R. F., Wong, C. H. Chemoenzymatic synthesis of a PSGL-1 N-terminal glycopeptide containing tyrosine sulfate and α-O-linked sialyl Lewis X Journal of the American Chemical Society 2000 122:4241-4242 DOI:10.1021/ja0004938
- Lin, Y. C., Beck, Z., Le, V. D., Morris, G. M., Olson, A. J., Wong, C. H., Elder, J. H., Lee, T. Alteration of substrate and inhibitor specificity of feline immunodeficiency virus protease Journal of Virology 2000 74:4710-4720 DOI:10.1128/jvi.74.10.4710-4720.2000 PMID:10775609 PMCID:PMC111993
- Koeller, K. M., Smith, M. E. B., Wong, C. H. Chemoenzymatic synthesis of PSGL-1 glycopeptides: sulfation on tyrosine affects glycosyltransferase-catalyzed synthesis of the O-glycan Bioorganic & Medicinal Chemistry 2000 8:1017-1025 DOI:10.1016/s0968-0896(00)00041-9 PMID:10882013
- Ye, X. S., Wong, C. H. Anomeric reactivity-based one-pot oligosaccharide synthesis: A rapid route to oligosaccharide libraries Journal of Organic Chemistry 2000 65:2410-2431 DOI:10.1021/jo991558w PMID:10789453
- Shibata, K., Hiruma, K., Kanie, O., Wong, C. H. Synthesis of 1,1-linked galactosyl mannosides carrying a thiazine ring as mimetics of sialyl lewis x antigen: Investigation of the effect of carboxyl group orientation on p-selectin inhibition Journal of Organic Chemistry 2000 65:2393-2398 DOI:10.1021/jo991556b PMID:10789451
- Le, V. D., Wong, C. H. Synthesis of 2-substituted polyhydroxytetrahydropyrimidines (n-hydroxy cyclic guanidino-sugars): Transition state mimics of enzymatic glycosidic cleavage Journal of Organic Chemistry 2000 65:2399-2409 DOI:10.1021/jo9915574 PMID:10789452
- Koeller, K. M., Wong, C. H. Chemoenzymatic synthesis of sialyl-trimeric-Lewis X Chemistry-a European Journal 2000 6:1243-1251 DOI:10.1002/(sici)1521-3765(20000403)6:7<1243::aid-chem1243>3.3.co;2-a PMID:10785811
- Nishide, K., Shibata, K., Fujita, T., Kajimoto, T., Wong, C. H., Node, M. An asymmetric total synthesis of a potent immunosuppressant, mycestericins D and F, through an aldol reaction using L-threonine aldolase Heterocycles 2000 52:1191-1201 DOI:10.3987/COM-99-S117
- Koeller, K. M., Smith, M. E. B., Wong, C. H. Tyrosine sulfation on a psgl-1 glycopeptide influences the reactivity of glycosyltransferases responsible for synthesis of the attached o-glycan Journal of the American Chemical Society 2000 122:742-743 DOI:10.1021/ja993820o
- Wittmann, V., Datta, A. K., Koeller, K. M., Wong, C. H. Chemoenzymatic synthesis and fluorescent visualization of cell-surface selectin-bound sialyl Lewis X derivatives Chemistry-a European Journal 2000 6:162-171 DOI:10.1002/(sici)1521-3765(20000103)6:1<162::aid-chem162>3.0.co;2-9 PMID:10747401
- Sucheck, S. J., Greenberg, W. A., Tolbert, T. J., Wong, C. H. Design of small molecules that recognize rna: Development of aminoglycosides as potential antitumor agents that target oncogenic rna sequences Angewandte Chemie-International Edition 2000 39:1080-1084 DOI:10.1002/(sici)1521-3773(20000317)39:6<1080::aid-anie1080>3.0.co;2-b PMID:10760928
- Sheppard, T. L., Wong, C. H., Joyce, G. F. Nucleoglycoconjugates: Design and synthesis of a new class of DNA-carbohydrate conjugates Angewandte Chemie-International Edition 2000 39:3660-3663 DOI:10.1002/1521-3773(20001016)39:20<3660::aid-anie3660>3.0.co;2-l PMID:11091431
- Kanie, O., Grotenbreg, G., Wong, C. H. Removal of benzyl protecting groups from solid-supported compounds by hydrogenolysis using palladium nanoparticles Angewandte Chemie-International Edition 2000 39:4545-4547 DOI:10.1002/1521-3773(20001215)39:24<4545::aid-anie4545>3.3.co;2-m PMID:11169665
- Li, M., Morris, G. M., Lee, T., Laco, G. S., Wong, C. H., Olson, A. J., Elder, J. H., Wlodawer, A., Gustchina, A. Structural studies of FIV and HIV-1 proteases complexed with all efficient inhibitor of FIV protease Proteins-Structure Function and Genetics 2000 38:29-40 DOI:10.1002/(sici)1097-0134(20000101)38:1<29::aid-prot4>3.0.co;2-n PMID:10651036
- Machajewski, T. D., Wong, C. H. The catalytic asymmetric aldol reaction Angewandte Chemie-International Edition 2000 39:1352-1374 DOI:10.1002/(sici)1521-3773(20000417)39:8<1352::aid-anie1352>3.0.co;2-j PMID:10777624
- Shen, G. J., Datta, A. K., Izumi, M., Koeller, K. M., Wong, C. H. Expression of α2,8/2,9-polysialyltransferase from escherichia coli K92 - characterization of the enzyme and its reaction products Journal of Biological Chemistry 1999 274:35139-35146 DOI:10.1074/jbc.274.49.35139 PMID:10574996
- Depre, D., Duffels, A., Green, L. G., Lenz, R., Ley, S. V., Wong, C. H. Synthesis of glycans from the glycodelins: Two undeca-, two deca-, three nona-, an octa- and a heptasaccharide Chemistry-a European Journal 1999 5:3326-3340 DOI:10.1002/(sici)1521-3765(19991105)5:11<3326::aid-chem3326>3.0.co;2-q
- Burkart, M. D., Wong, C. H. A continuous assay for the spectrophotometric analysis of sulfotransferases using aryl sulfotransferase iv Analytical Biochemistry 1999 274:131-137 DOI:10.1006/abio.1999.4264 PMID:10527506
- Koeller, K. M., Wong, C. H. Synthesis of biologically active glycopeptides Journal of the Chinese Chemical Society 1999 46:659-685
- Hiranuma, S., Kanie, O., Wong, C. H. Formation of the 1,2,6-orthoester of mannose and its utilization in the glycosylation reaction Tetrahedron Letters 1999 40:6423-6426 DOI:10.1016/s0040-4039(99)01193-4
- Burkart, M. D., Vincent, S. P., Wong, C. H. An efficient synthesis of cmp-3-fluoroneuraminic acid Chemical Communications 1999 1525-1526 DOI:10.1039/a903362i
- Weitz-Schmidt, G., Gong, K. W., Wong, C. H. Selectin/glycoconjugate binding assays for the identification and optimization of selectin antagonists Analytical Biochemistry 1999 273:81-88 DOI:10.1006/abio.1999.4180 PMID:10452802
- Greenberg, W. A., Priestley, E. S., Sears, P. S., Alper, P. B., Rosenbohm, C., Hendrix, M., Hung, S. C., Wong, C. H. Design and synthesis of new aminoglycoside antibiotics containing neamine as an optimal core structure: Correlation of antibiotic activity with in vitro inhibition of translation Journal of the American Chemical Society 1999 121:6527-6541 DOI:10.1021/ja9910356
- Takebayashi, M., Hiranuma, S., Kanie, Y., Kajimoto, T., Kanie, O., Wong, C. H. A versatile synthetic strategy for the preparation and discovery of new iminocyclitols as inhibitors of glycosidases Journal of Organic Chemistry 1999 64:5280-5291 DOI:10.1021/jo9902446
- Vincent, S. P., Burkart, M. D., Tsai, C. Y., Zhang, Z. Y., Wong, C. H. Electrophilic fluorination-nucleophilic addition reaction mediated by selectfluor: Mechanistic studies and new applications Journal of Organic Chemistry 1999 64:5264-5279 DOI:10.1021/jo990686h
- Mao, S. L., Gao, C., Lo, C. H. L., Wirsching, P., Wong, C. H., Janda, K. D. Phage-display library selection of high-affinity human single-chain antibodies to tumor-associated carbohydrate antigens sialyl Lewis(x) and Lewis(x) Proceedings of the National Academy of Sciences of the United States of America 1999 96:6953-6958 DOI:10.1073/pnas.96.12.6953 PMID:10359820
- Wong, C. H. Design and synthesis of carbohydrate mimetics: A new strategy for tackling the problem of carbohydrate-mediated biological recognition Journal of the Chinese Chemical Society 1999 46:271-281
- Huwe, C. M., Woltering, T. J., Jiricek, J., Weitz-Schmidt, G., Wong, C. H. Design, synthesis and biological evaluation of aryl-substituted sialyl lewis x mimetics prepared via cross-metathesis of c-fucopeptides Bioorganic & Medicinal Chemistry 1999 7:773-788 DOI:10.1016/s0968-0896(98)00245-4 PMID:10400330
- Zhang, X. D., Rosenthal, P. B., Formanowski, F., Fitz, W., Wong, C. H., Meier-Ewert, H., Skehel, J. J., Wiley, D. C. X-ray crystallographic determination of the structure of the influenza c virus haemagglutinin-esterase-fusion glycoprotein Acta Crystallographica Section D-Biological Crystallography 1999 55:945-961 DOI:10.1107/s0907444999000232 PMID:10216291
- Wong, C. H. Mimics of complex carbohydrates recognized by receptors Accounts of Chemical Research 1999 32:376-385 DOI:10.1021/ar960237t
- Wu, W. G., Pasternack, L., Huang, D. H., Koeller, K. M., Lin, C. C., Seitz, O., Wong, C. H. Structural study on O-glycopeptides: Glycosylation-induced conformational changes of O-GlcNAc, O-LacNAc, O-Sialyl-LacNAc, and O-Sialyl-Lewis-X peptides of the mucin domain of madcam-1 Journal of the American Chemical Society 1999 121:2409-2417 DOI:10.1021/ja983474v
- Sears, P., Witte, K., Wong, C. H. The effect of counterion, water concentration, and stirring on the stability of subtilisin BPN′ in organic solvents Journal of Molecular Catalysis B-Enzymatic 1999 6:297-304 DOI:10.1016/s1381-1177(98)00085-x
- Lin, C. C., Moris-Varas, F., Weitz-Schmidt, G., Wong, C. H. Synthesis of sialyl Lewis x mimetics as selectin inhibitors by enzymatic aldol condensation reactions Bioorganic & Medicinal Chemistry 1999 7:425-433 DOI:10.1016/s0968-0896(98)00242-9 PMID:10220028
- Yuasa, H., Hashimoto, H., Abe, Y., Kajimoto, T., Wong, C. H. Studies on the unusual stability of cis-2,5-diethoxy-2,5-bis(hydroxymethyl)-1,4-dioxane Tetrahedron 1999 55:2193-2204 DOI:10.1016/s0040-4020(99)00003-4
- Lee, T. Y., Le, V. D., Lim, D. Y., Lin, Y. C., Morris, G. M., Wong, A. L., Olson, A. J., Elder, J. H., Wong, C. H. Development of a new type of protease inhibitors, efficacious against FIV and HIV variants Journal of the American Chemical Society 1999 121:1145-1155 DOI:10.1021/ja982893p
- Zhang, Z. Y., Ollmann, I. R., Ye, X. S., Wischnat, R., Baasov, T., Wong, C. H. Programmable one-pot oligosaccharide synthesis Journal of the American Chemical Society 1999 121:734-753 DOI:10.1021/ja982232s
- Kidd, R. D., Sears, P., Huang, D. H., Witte, K., Wong, C. H., Farber, G. K. Breaking the low barrier hydrogen bond in a serine protease Protein Science 1999 8:410-417 DOI:10.1110/ps.8.2.410 PMID:10048334 PMCID:PMC2144249
- Takayama, S., Chung, S. J., Igarashi, Y., Ichikawa, Y., Sepp, A., Lechler, R. I., Wu, J., Hayashi, T., Siuzdak, G., Wong, C. H. Selective inhibition of β-1,4- and α-1,3-galactosyltransferases: donor sugar-nucleotide based approach Bioorganic & Medicinal Chemistry 1999 7:401-409 DOI:10.1016/s0968-0896(98)00249-1 PMID:10218835
- Takayama, S., Lee, S. T., Hung, S. C., Wong, C. H. Designing enzymatic resolution of amines Chemical Communications 1999 127-128 DOI:10.1039/a808028c
- Sears, P., Wong, C. H. Carbohydrate mimetics: a new strategy for tackling the problem of carbohydrate-mediated biological recognition Angewandte Chemie-International Edition 1999 38:2300-2324 DOI:10.1002/(SICI)1521-3773(19990816)38:16<2300::AID-ANIE2300>3.0.CO;2-6 PMID:10458780
- Machajewski, T. D., Wong, C. H. Chemoenzymatic synthesis of key epothilone fragments Synthesis-Stuttgart 1999 1469-1472
- Burkart, M. D., Izumi, M., Wong, C. H. Enzymatic regeneration of 3 '-phosphoadenosine-5 '-phosphosulfate using aryl sulfotransferase for the preparative enzymatic synthesis of sulfated carbohydrates Angewandte Chemie-International Edition 1999 38:2747-2750 DOI:10.1002/(sici)1521-3773(19990917)38:18<2747::aid-anie2747>3.0.co;2-2 PMID:10508369
- Hiruma, K., Kanie, O., Wong, C. H. Synthesis of analogs of 1,1-linked galactosyl mannoside as mimetics of sialyl lewis x tetrasaccharide Tetrahedron 1998 54:15781-15792 DOI:10.1016/s0040-4020(98)00990-9
- Witte, K., Skolnick, J., Wong, C. H. A synthetic retrotransition (backward reading) sequence of the right-handed three-helix bundle domain (10-53) of protein a shows similarity in conformation as predicted by computation Journal of the American Chemical Society 1998 120:13042-13045 DOI:10.1021/ja982203h
- Chung, S. J., Takayama, S., Wong, C. H. Acceptor substrate-based selective inhibition of galactosyltransferases Bioorganic & Medicinal Chemistry Letters 1998 8:3359-3364 DOI:10.1016/s0960-894x(98)00618-0 PMID:9873734
- Wischnat, R., Martin, R., Takayama, S., Wong, C. H. Chemoenzymatic synthesis of iminocyclitol derivatives: A useful library strategy for the development of selective fucosyltransfer enzymes inhibitors Bioorganic & Medicinal Chemistry Letters 1998 8:3353-3358 DOI:10.1016/s0960-894x(98)00617-9 PMID:9873733
- Simanek, E. E., Huang, D. H., Pasternack, L., Machajewski, T. D., Seitz, O., Millar, D. S., Dyson, H. J., Wong, C. H. Glycosylation of threonine of the repeating unit of RNA polymerase II with beta-linked N-acetylglucosame leads to a turnlike structure Journal of the American Chemical Society 1998 120:11567-11575 DOI:10.1021/ja982312w
- Wischnat, R., Martin, R., Wong, C. H. Synthesis of a new class of n-linked lewis and lacnac analogues as potential inhibitors of human fucosyltransferases: A general method for the incorporation of an iminocyclitol as a transition-state mimetic of the donor sugar to the acceptor Journal of Organic Chemistry 1998 63:8361-8365 DOI:10.1021/jo981245l
- Rosenthal, P. B., Zhang, X. D., Formanowski, F., Fitz, W., Wong, C. H., Meier-Ewert, H., Skehel, J. J., Wiley, D. C. Structure of the haemagglutinin-esterase-fusion glycoprotein of influenza c virus Nature 1998 396:92-96 PMID:9817207
- Guo, C. T., Wong, C. H., Kajimoto, T., Miura, T., Ida, Y., Juneja, L. R., Kim, M. J., Masuda, H., Suzuki, T., Suzuki, Y. Synthetic sialylphosphatidylethanolamine derivatives bind to human influenza a viruses and inhibit viral infection Glycoconjugate Journal 1998 15:1099-1108 DOI:10.1023/a:1006961912465 PMID:10386895
- Kanie, Y., Kirsch, A., Kanie, O., Wong, C. H. Enzymatic assay of galactosyltransferase by capillary electrophoresis Analytical Biochemistry 1998 263:240-245 DOI:10.1006/abio.1998.2762 PMID:9799537
- Tsai, C. Y., Park, W. K. C., Weitz-Schmidt, G., Ernst, B., Wong, C. H. Synthesis of sialyl lewis x mimetics using the ugi four-component reaction Bioorganic & Medicinal Chemistry Letters 1998 8:2333-2338 DOI:10.1016/s0960-894x(98)00422-3 PMID:9873537
- Vassilev, V. P., Simanek, E. E., Wood, M. R., Wong, C. H. Enzymatic synthesis of a chiral gelator with remarkably low molecular weight Chemical Communications 1998 1865-1866 DOI:10.1039/a803230k
- Hogg, J. H., Ollmann, I. R., Wetterholm, A., Andberg, M. B., Haeggstrom, J., Samuelsson, B., Wong, C. H. Probing the activities and mechanisms of leukotriene a(4) hydrolase with synthetic inhibitors Chemistry-a European Journal 1998 4:1698-1713 DOI:10.1002/(sici)1521-3765(19980904)4:9<1698::aid-chem1698>3.3.co;2-a
- Miura, T., Kajimoto, T., Jimbo, M., Yamagishi, K., Inokuchi, J. C., Wong, C. H. Synthesis and evaluation of morpholino- and pyrrolidinosphingolipids as inhibitors of glucosylceramide synthase Bioorganic & Medicinal Chemistry 1998 6:1481-1489 DOI:10.1016/s0968-0896(98)00077-7 PMID:9801819
- Wong, C. H.*, Hendrix, M.*, Manning, D. D., Rosenbohm, C., Greenberg, W. A. A library approach to the discovery of small molecules that recognize rna: Use of a 1,3-hydroxyamine motif as core Journal of the American Chemical Society 1998 120:8319-8327 DOI:10.1021/ja980826p (* = equal contribution)
- Martin, R., Witte, K. L., Wong, C. H. The synthesis and enzymatic incorporation of sialic acid derivatives for use as tools to study the structure, activity, and inhibition of glycoproteins and other glycoconjugates Bioorganic & Medicinal Chemistry 1998 6:1283-1292 DOI:10.1016/s0968-0896(98)00121-7 PMID:9784869
- Wittmann, V., Takayama, S., Gong, K. W., Weitz-Schmidt, G., Wong, C. H. Ligand recognition by E- and P-selectin: Chemoenzymatic synthesis and inhibitory activity of bivalent sialyl Lewis x derivatives and sialyl Lewis x carboxylic acids Journal of Organic Chemistry 1998 63:5137-5143 DOI:10.1021/jo980350s
- Wong, C. H., Ye, X. S., Zhang, Z. Y. Assembly of oligosaccharide libraries with a designed building block and an efficient orthogonal protection-deprotection strategy Journal of the American Chemical Society 1998 120:7137-7138 DOI:10.1021/ja9813616
- Lampe, T. F. J., Weitz-Schmidt, G., Wong, C. H. Parallel synthesis of sialyl lewis x mimetics on a solid phase: Access to a library of fucopeptides Angewandte Chemie-International Edition 1998 37:1707-1711 DOI:10.1002/(sici)1521-3773(19980703)37:12<1707::aid-anie1707>3.3.co;2-m
- Wong, C. H.*, Hendrix, M.*, Priestley, E. S., Greenberg, W. A. Specificity of aminoglycoside antibiotics for the a-site of the decoding region of ribosomal rna Chemistry & Biology 1998 5:397-406 DOI:10.1016/s1074-5521(98)90073-4 PMID:9662506 (* = equal contribution)
- Kamitakahara, H., Suzuki, T., Nishigori, N., Suzuki, Y., Kanie, O., Wong, C. H. A lysoganglioside poly-l-glutamic acid conjugate as a picomolar inhibitor of influenza hemagglutinin Angewandte Chemie-International Edition 1998 37:1524-1528 DOI:10.1002/(sici)1521-3773(19980619)37:11<1524::aid-anie1524>3.3.co;2-4
- Sears, P., Wong, C. H. Mechanism-based inhibition of carbohydrate-mediated biological recognitions Chemical Communications 1998 1161-1170 DOI:10.1039/a800838h
- Anderson, C. M., Mandell, A. J., Selz, K. A., Terry, L. M., Wong, C. H., Robinson, S. R., Robertson, S. S., Smotherman, W. P. The development of nuchal atonia associated with active (rem) sleep in fetal sheep: Presence of recurrent fractal organization Brain Research 1998 787:351-357 DOI:10.1016/s0006-8993(98)00008-0 PMID:9518691
- Alper, P. B., Hendrix, M., Sears, P., Wong, C. H. Probing the specificity of aminoglycoside ribosomal rna interactions with designed synthetic analogs Journal of the American Chemical Society 1998 120:1965-1978 DOI:10.1021/ja972599h
- Witte, K., Seitz, O., Wong, C. H. Solution- and solid-phase synthesis of n-protected glycopeptide esters of the benzyl type as substrates for subtilisin-catalyzed glycopeptide couplings Journal of the American Chemical Society 1998 120:1979-1989 DOI:10.1021/ja9736727
- Sears, P., Wong, C. H. Enzyme action in glycoprotein synthesis Cellular and Molecular Life Sciences 1998 54:223-252 DOI:10.1007/s000180050146 PMID:9575336
- Simanek, E. E., McGarvey, G. J., Jablonowski, J. A., Wong, C. H. Selectin-carbohydrate interactions: From natural ligands to designed mimics Chemical Reviews 1998 98:833-862 DOI:10.1021/cr940226i PMID:11848916
- Lee, T., Laco, G. S., Torbett, B. E., Fox, H. S., Lerner, D. L., Elder, J. H., Wong, C. H. Analysis of the S3 and S3' subsite specificities of feline immunodeficiency virus (FIV) protease: development of a broad-based protease inhibitor efficacious against FIV, SIV, and HIV in vitro and ex vivo Proceedings of the National Academy of Sciences of the United States of America 1998 95:939-944 DOI:10.1073/pnas.95.3.939 PMID:9448264 PMCID:PMC18632
- Kanemitsu, T., Kanie, O., Wong, C. H. Quantitative monitoring of solid-phase synthesis using gated decoupling c-13 NMR spectroscopy with a c-13-enriched protecting group and an internal standard in the synthesis of sialyl lewis(x) tetrasaccharide Angewandte Chemie-International Edition 1998 37:3415-3418 DOI:10.1002/(sici)1521-3773(19981231)37:24<3415::aid-anie3415>3.0.co;2-8
- Burkart, M. D., Zhang, Z. Y., Hung, S. C., Wong, C. H. A new method for the synthesis of fluoro-carbohydrates and glycosides using selectfluor Journal of the American Chemical Society 1997 119:11743-11746 DOI:10.1021/ja9723904
- Kimura, T., Vassilev, V. P., Shen, G. J., Wong, C. H. Enzymatic synthesis of beta-hydroxy-alpha-amino acids based on recombinant d- and l-threonine aldolases Journal of the American Chemical Society 1997 119:11734-11742 DOI:10.1021/ja9720422
- Takayama, S., McGarvey, G. J., Wong, C. H. Enzymes in organic synthesis: Recent developments in aldol reactions and glycosylations Chemical Society Reviews 1997 26:407-415 DOI:10.1039/cs9972600407
- Kaneko, M., Kanie, O., Kajimoto, T., Wong, C. H. Toward a transition state analog inhibitor of n-acetylglucosaminyl transferase v Bioorganic & Medicinal Chemistry Letters 1997 7:2809-2812 DOI:10.1016/s0960-894x(97)10087-7
- Koketsu, M., Nitoda, T., Sugino, H., Juneja, L. R., Kim, M., Yamamoto, T., Abe, N., Kajimoto, T., Wong, C. H. Synthesis of a novel sialic acid derivative (sialylphospholipid) as an antirotaviral agent Journal of Medicinal Chemistry 1997 40:3332-3335 DOI:10.1021/jm9701280 PMID:9341907
- Ikeda, T., Kajimoto, T., Kondo, H., Wong, C. H. Design and synthesis of an alpha-mannosyl terpenoid as selective inhibitor of p-selectin Bioorganic & Medicinal Chemistry Letters 1997 7:2485-2490 DOI:10.1016/s0960-894x(97)10022-1
- Seitz, O., Wong, C. H. Chemoenzymatic solution- and solid-phase synthesis of o-glycopeptides of the mucin domain of madcam-1. A general route to o-lacnac, o-sialyl-lacnac, and o-sialyl-lewis-x peptides Journal of the American Chemical Society 1997 119:8766-8776 DOI:10.1021/ja971383c
- Takayama, S., Martin, R., Wu, J., Laslo, K., Siuzdak, G., Wong, C. H. Chemoenzymatic preparation of novel cyclic imine sugars and rapid biological activity evaluation using electrospray mass spectrometry and kinetic analysis Journal of the American Chemical Society 1997 119:8146-8151 DOI:10.1021/ja971695f
- Wong, C. H., MorisVara, F., Hung, S. C., Marron, T. G., Lin, C. C., Gong, K. W., WeitzSchmidt, G. Small molecules as structural and functional mimics of sialyl Lewis X tetrasaccharide in selectin inhibition: A remarkable enhancement of inhibition by additional negative charge and/or hydrophobic group Journal of the American Chemical Society 1997 119:8152-8158 DOI:10.1021/ja970920q
- Wu, J., Takayama, S., Wong, C. H., Siuzdak, G. Quantitative electrospray mass spectrometry for the rapid assay of enzyme inhibitors Chemistry & Biology 1997 4:653-657 DOI:10.1016/s1074-5521(97)90220-9 PMID:9331404
- Hung, S. C., Lin, C. C., Wong, C. H. One-pot synthesis of 1-allyl- and 1-allenyl-6-O-acetyl-2,3,4-tri-O-benzyl-α-D-glycosides from methyl tetra-O-benzyl-α-D-glycosides Tetrahedron Letters 1997 38:5419-5422 DOI:10.1016/s0040-4039(97)01204-5
- Takayama, S., Wong, C. H. Chemo-enzymatic approach to carbohydrate recognition Current Organic Chemistry 1997 1:109-126
- McGarvey, G. J., Wong, C. H. Chemical, enzymatic and structural studies in molecular glycobiology Liebigs Annalen-Recueil 1997 1059-1074
- Kim, M. J., Lim, I. T., Kim, H. J., Wong, C. H. Enzymatic single aldol reactions of remote dialdehydes Tetrahedron-Asymmetry 1997 8:1507-1509 DOI:10.1016/s0957-4166(97)00139-0
- Moree, W. J., Sears, P., Kawashiro, K., Witte, K., Wong, C. H. Exploitation of subtilisin bpn' as catalyst for the synthesis of peptides containing noncoded amino acids, peptide mimetics and peptide conjugates Journal of the American Chemical Society 1997 119:3942-3947 DOI:10.1021/ja964399w
- Hendrix, M., Priestley, E. S., Joyce, G. F., Wong, C. H. Direct observation of aminoglycoside-RNA interactions by surface plasmon resonance Journal of the American Chemical Society 1997 119:3641-3648 DOI:10.1021/ja964290o PMID:11540136
- Lin, C. C., Lin, C. H., Wong, C. H. Sialic acid aldolase-catalyzed condensation of pyruvate and N-substituted mannosamine: A useful method for the synthesis of N-substituted sialic acids Tetrahedron Letters 1997 38:2649-2652 DOI:10.1016/s0040-4039(97)00442-5
- Wittmann, V., Wong, C. H. 1H-tetrazole as catalyst in phosphomorpholidate coupling reactions: efficient synthesis of GDP-fucose, GDP-mannose, and UDP-galactose Journal of Organic Chemistry 1997 62:2144-2147 DOI:10.1021/jo9620066 PMID:11671520
- Wang, R., Steensma, D. H., Takaoka, Y., Yun, J. W., Kajimoto, T., Wong, C. H. A search for pyrophosphate mimics for the development of substrates and inhibitors of glycosyltransferases Bioorganic & Medicinal Chemistry 1997 5:661-672 DOI:10.1016/s0968-0896(97)00005-9 PMID:9158864
- Witte, K., Sears, P., Martin, R., Wong, C. H. Enzymatic glycoprotein synthesis: Preparation of ribonuclease glycoforms via enzymatic glycopeptide condensation and glycosylation Journal of the American Chemical Society 1997 119:2114-2118 DOI:10.1021/ja961846z
- Wong, C. H. A chemo-enzymatic approach to the study of carbohydrate-based biological recognitions Pure and Applied Chemistry 1997 69:419-422 DOI:10.1351/pac199769030419
- Hayashi, T., Murray, B. W., Wang, R., Wong, C. H. A chemoenzymatic synthesis of UDP-(2-deoxy-2-fluoro)-galactose and evaluation of its interaction with galactosyltransferase Bioorganic & Medicinal Chemistry 1997 5:497-500 DOI:10.1016/s0968-0896(96)00263-5 PMID:9113327
- Janda, K. D., Lo, L. C., Lo, C. H. L., Sim, M. M., Wang, R., Wong, C. H., Lerner, R. A. Chemical selection for catalysis in combinatorial antibody libraries Science 1997 275:945-948 DOI:10.1126/science.275.5302.945 PMID:9020070
- Murray, B. W., Wittmann, V., Burkart, M. D., Hung, S. C., Wong, C. H. Mechanism of human alpha-1,3-fucosyltransferase v: Glycosidic cleavage occurs prior to nucleophilic attack Biochemistry 1997 36:823-831 DOI:10.1021/bi962284z PMID:9020780
- Lin, C. H., Murray, B. W., Ollmann, I. R., Wong, C. H. Why is CMP-ketodeoxyoctonate highly unstable? Biochemistry 1997 36:780-785 DOI:10.1021/bi962055c PMID:9020775
- Hendrix, M., Alper, P. B., Priestley, E. S., Wong, C. H. Hydroxyamines as a new motif for the molecular recognition of phosphodiesters: Implications for aminoglycoside-rna interactions Angewandte Chemie-International Edition 1997 36:95-98 DOI:10.1002/anie.199700951
- Takayama, S., McGarvey, G. J., Wong, C. H. Microbial aldolases and transketolases: New biocatalytic approaches to simple and complex sugars Annual Review of Microbiology 1997 51:285-310 DOI:10.1146/annurev.micro.51.1.285 PMID:9343352
- Cappi, M. W., Moree, W. J., Qiao, L., Marron, T. G., WeitzSchmidt, G., Wong, C. H. Synthesis of novel 6-amido-6-deoxy-l-galactose derivatives as sialyl lewis x mimetics Bioorganic & Medicinal Chemistry 1997 5:283-296 DOI:10.1016/s0968-0896(96)00236-2 PMID:9061193
- Takayama, S., Livingston, P. O., Wong, C. H. Synthesis of the melanoma-associated ganglioside 9-O-acetyl GD3 through regioselective enzymatic acetylation of GD3 using subtilisin Tetrahedron Letters 1996 37:9271-9274 DOI:10.1016/s0040-4039(97)82939-5
- Woltering, T. J., WeitzSchmidt, G., Wong, C. H. C-fucopeptides as selectin antagonists: Attachment of lipid moieties enhances the activity Tetrahedron Letters 1996 37:9033-9036 DOI:10.1016/s0040-4039(96)02121-1
- Marron, T. G., Woltering, T. J., WeitzSchmidt, G., Wong, C. H. C-mannose derivatives as potent mimics of sialyl lewis x Tetrahedron Letters 1996 37:9037-9040 DOI:10.1016/s0040-4039(96)02124-7
- Qian, X. H., MorisVaras, F., Fitzgerald, M. C., Wong, C. H. C-2-symmetrical tetrahydroxyazepanes as inhibitors of glycosidases and hiv/fiv proteases Bioorganic & Medicinal Chemistry 1996 4:2055-2069 DOI:10.1016/s0968-0896(96)00218-0 PMID:9022971
- Lin, C. C., Kimura, T., Wu, S. H., WeitzSchmidt, G., Wong, C. H. Liposome-like fucopeptides as sialyl Lewis X mimetics Bioorganic & Medicinal Chemistry Letters 1996 6:2755-2760 DOI:10.1016/s0960-894x(96)00509-4
- Hendrix, M., Wong, C. H. A chemoenzymatic approach to carbohydrate-mediated cell adhesion Pure and Applied Chemistry 1996 68:2081-2087 DOI:10.1351/pac199668112081
- Sears, P., Wong, C. H. Intervention of carbohydrate recognition by proteins and nucleic acids Proceedings of the National Academy of Sciences of the United States of America 1996 93:12086-12093 DOI:10.1073/pnas.93.22.12086 PMID:8901537
- Park, W. K. C., Auer, M., Jaksche, H., Wong, C. H. Rapid combinatorial synthesis of aminoglycoside antibiotic mimetics: Use of a polyethylene glycol-linked amine and a neamine-derived aldehyde in multiple component condensation as a strategy for the discovery of new inhibitors of the hiv rna rev responsive element Journal of the American Chemical Society 1996 118:10150-10155 DOI:10.1021/ja9612817
- Hiruma, K., Kajimoto, T., WeitzSchmidt, G., Ollmann, I., Wong, C. H. Rational design and synthesis of a 1,1-linked disaccharide that is 5 times as active as sialyl lewis x in binding to e-selectin Journal of the American Chemical Society 1996 118:9265-9270 DOI:10.1021/ja9611093
- Murray, B. W., Takayama, S., Schultz, J., Wong, C. H. Mechanism and specificity of human α-1,3-fucosyltransferase V Biochemistry 1996 35:11183-11195 DOI:10.1021/bi961065a PMID:8780523
- Takayama, S., Moree, W. J., Wong, C. H. Enzymatic resolution of amines and amino alcohols using pent-4-enoyl derivatives Tetrahedron Letters 1996 37:6287-6290 DOI:10.1016/0040-4039(96)01378-0
- MorisVaras, F., Qian, X. H., Wong, C. H. Enzymatic/chemical synthesis and biological evaluation of seven-membered iminocyclitols Journal of the American Chemical Society 1996 118:7647-7652 DOI:10.1021/ja960975c
- Qiao, L., Murray, B. W., Shimazaki, M., Schultz, J., Wong, C. H. Synergistic inhibition of human alpha-1,3-fucosyltransferase v Journal of the American Chemical Society 1996 118:7653-7662 DOI:10.1021/ja960274f
- Alper, P. B., Hung, S. C., Wong, C. H. Metal catalyzed diazo transfer for the synthesis of azides from amines Tetrahedron Letters 1996 37:6029-6032 DOI:10.1016/0040-4039(96)01307-x
- Fitz, W., Rosenthal, P. B., Wong, C. H. Synthesis and inhibitory properties of a thiomethylmercuric sialic acid with application to the x-ray structure determination of 9-o-acetylsialic acid esterase from influenza c virus Bioorganic & Medicinal Chemistry 1996 4:1349-1353 DOI:10.1016/0968-0896(96)00123-x PMID:8879557
- Wang, R., Wong, C. H. Synthesis of sialyl Lewis X mimetics: Use of O-α-fucosyl-(1R, 2R)-2-aminocyclohexanol as core structure Tetrahedron Letters 1996 37:5427-5430 DOI:10.1016/0040-4039(96)01114-8
- Lin, C. C., Shimazaki, M., Heck, M. P., Aoki, S., Wang, R., Kimura, T., Ritzen, H., Takayama, S., Wu, S. H., WeitzSchmidt, G., Wong, C. H. Synthesis of sialyl Lewis X mimetics and related structures using the glycosyl phosphite methodology and evaluation of E-selectin inhibition Journal of the American Chemical Society 1996 118:6826-6840 DOI:10.1021/ja952265x
- Hung, S. C., Wong, C. H. Synthesis of glycosyl chlorides with acid-labile protecting groups Tetrahedron Letters 1996 37:4903-4906 DOI:10.1016/0040-4039(96)01006-4
- Uchiyama, T., Woltering, T. J., Wong, W. C., Lin, C. C., Kajimoto, T., Takebayashi, M., WeitzSchmidt, G., Asakura, T., Noda, M., Wong, C. H. Design and synthesis of C-linked fucosides as inhibitors of E-selectin Bioorganic & Medicinal Chemistry 1996 4:1149-1165 DOI:10.1016/0968-0896(96)00127-7 PMID:8831987
- Sears, P., Wong, C. H. Engineering enzymes for bioorganic synthesis: Peptide bond formation Biotechnology Progress 1996 12:423-433 DOI:10.1021/bp9500730
- Patterson, J. E., Ollmann, I. R., Cravatt, B. F., Boger, D. L., Wong, C. H., Lerner, R. A. Inhibition of oleamide hydrolase catalyzed hydrolysis of the endogenous sleep-inducing lipid cis-9-octadecenamide Journal of the American Chemical Society 1996 118:5938-5945 DOI:10.1021/ja954064z
- Qian, X. H., MorisVaras, F., Wong, C. H. Synthesis of c-2-symmetrical polyhydroxyazepanes as inhibitors of glycosidases Bioorganic & Medicinal Chemistry Letters 1996 6:1117-1122
- Takayama, S., Shimazaki, M., Qiao, L., Wong, C. H. Synthesis of lactosamine derivatives using beta-d-galactosidase from bacillus circulans Bioorganic & Medicinal Chemistry Letters 1996 6:1123-1126 DOI:10.1016/0960-894x(96)00184-9
- Jeong, J. H., Murray, B. W., Takayama, S., Wong, C. H. Cyclic guanidino-sugars with low pKa as transition-state analog inhibitors of glycosidases: Neutral instead of charged species are the active forms Journal of the American Chemical Society 1996 118:4227-4234 DOI:10.1021/ja951602z
- Shibata, K., Shingu, K., Vassilev, V. P., Nishide, K., Fujita, T., Node, M., Kajimoto, T., Wong, C. H. Kinetic and thermodynamic control of l-threonine aldolase catalyzed reaction and its application to the synthesis of mycestericin d Tetrahedron Letters 1996 37:2791-2794 DOI:10.1016/0040-4039(96)00430-3
- Wong, C. H. Chemoenzymatic synthesis: Application to the study of carbohydrate recognition Acta Chemica Scandinavica 1996 50:211-218 DOI:10.3891/acta.chem.scand.50-0211 PMID:8901174
- Kidd, R. D., Yennawar, H. P., Sears, P., Wong, C. H., Farber, G. K. A weak calcium binding site in subtilisin BPN' has a dramatic effect on protein stability Journal of the American Chemical Society 1996 118:1645-1650 DOI:10.1021/ja953443p
- Orsat, B., Alper, P. B., Moree, W., Mak, C. P., Wong, C. H. Homocarbonates as substrates for the enantioselective enzymatic protection of amines Journal of the American Chemical Society 1996 118:712-713 DOI:10.1021/ja9533048
- Hendrix, M., Wong, C. H. A chemo-enzymatic approach to the study of carbohydrate recognition in biological systems Enantiomer 1996 1:305-310 PMID:9676274
- Kimura, T., Takayama, S., Huang, H. M., Wong, C. H. A practical method for the synthesis of N-acetyl-D-lactosamine derivatives by the tandem use of galactose oxidase and β-galactosidase Angewandte Chemie-International Edition 1996 35:2348-2350 DOI:10.1002/anie.199623481
- DeLuca, C., Lansing, M., Crescenzi, F., Martini, I., Shen, G. J., Oregan, M., Wong, C. H. Overexpression, one-step purification and characterization of udp-glucose dehydrogenase and udp-n-acetylglucosamine pyrophosphorylase Bioorganic & Medicinal Chemistry 1996 4:131-141 DOI:10.1016/0968-0896(95)00159-x PMID:8689233
- Gijsen, H. J. M., Qiao, L., Fitz, W., Wong, C. H. Recent advances in the chemoenzymatic synthesis of carbohydrates and carbohydrate mimetics Chemical Reviews 1996 96:443-473 DOI:10.1021/cr950031q PMID:11848760
- Hung, S. C., Wong, C. H. Samarium diiodide mediated coupling of glycosyl phosphates with carbon radical or anion acceptors - synthesis of c-glycosides Angewandte Chemie-International Edition 1996 35:2671-2674 DOI:10.1002/anie.199626711
- Wu, S. H., Shimazaki, M., Lin, C. C., Qiao, L., Moree, W. J., WeitzSchmidt, G., Wong, C. H. Synthesis of fucopeptides as sialyl lewis X mimetics Angewandte Chemie-International Edition 1996 35:88-90 DOI:10.1002/anie.199600881
- Cappi, M. W., Moree, W. J., Qiao, L., Marron, T. G., WeitzSchmidt, G., Wong, C. H. The synthesis of novel 6-amido-6-deoxy-l-galactose derivatives as potent sialyl lewis(x) mimetics Angewandte Chemie-International Edition 1996 35:2346-2348 DOI:10.1002/anie.199623461
- Slee, D. H., Laslo, K. L., Elder, J. H., Ollmann, I. R., Gustchina, A., Kervinen, J., Zdanov, A., Wlodawer, A., Wong, C. H. Selectivity in the inhibition of HIV and FIV protease - inhibitory and mechanistic studies of pyrrolidine-containing alpha-keto amide and hydroxyethylamine core structures Journal of the American Chemical Society 1995 117:11867-11878 DOI:10.1021/ja00153a008
- Lin, C. H., Shimazaki, M., Wong, C. H., Koketsu, M., Juneja, L. R., Kim, M. Enzymatic synthesis of a sialyl Lewis X dimer from egg yolk as an inhibitor of E-selectin Bioorganic & Medicinal Chemistry 1995 3:1625-1630 DOI:10.1016/0968-0896(95)00150-6 PMID:8770386
- Hiranuma, S., Shimizu, T., Nakata, T., Kajimoto, T., Wong, C. H. Synthesis and inhibition analysis of 5-membered homoazasugars from d-arabinofuranose via an sn2 reaction of the chloromethylsulfonate Tetrahedron Letters 1995 36:8247-8250 DOI:10.1016/0040-4039(95)01769-e
- Wong, C. H., Alajarin, R., Morisvaras, F., Blanco, O., Garciajunceda, E. Enzymatic-synthesis of l-fucose and analogs Journal of Organic Chemistry 1995 60:7360-7363 DOI:10.1021/jo00127a052
- Garciajunceda, E., Shen, G. J., Alajarin, R., Wong, C. H. Cloning and overexpression of rhamnose isomerase and fucose isomerase Bioorganic & Medicinal Chemistry 1995 3:1349-1355 DOI:10.1016/0968-0896(95)00119-2 PMID:8564401
- Wong, C. H. Enzymatic and chemoenzymatic synthesis of carbohydrates Pure and Applied Chemistry 1995 67:1609-1616 DOI:10.1351/pac199567101609
- Wetterholm, A., Haeggstrom, J. Z., Samuelsson, B., Yuan, W., Munoz, B., Wong, C. H. Potent and selective inhibitors of leukotriene a(4) hydrolase - effects on purified enzyme and human polymorphonuclear leukocytes Journal of Pharmacology and Experimental Therapeutics 1995 275:31-37 PMID:7562564
- Gijsen, H. J. M., Wong, C. H. Synthesis of a cyclitol via a tandem enzymatic aldol - intramolecular horner-wadsworth-emmons reaction Tetrahedron Letters 1995 36:7057-7060 DOI:10.1016/0040-4039(95)01483-x
- Lin, C. H., Shen, G. J., Garciajunceda, E., Wong, C. H. Enzymatic-synthesis and regeneration of 3'-phosphoadenosine 5'-phosphosulfate (PAPS) for regioselective sulfation of oligosaccharides Journal of the American Chemical Society 1995 117:8031-8032 DOI:10.1021/ja00135a028
- Gijsen, H. J. M., Wong, C. H. Sequential 3-substrate and 4-substrate aldol reactions catalyzed by aldolases Journal of the American Chemical Society 1995 117:7585-7591 DOI:10.1021/ja00134a001
- Vassilev, V. P., Uchiyama, T., Kajimoto, T., Wong, C. H. An efficient chemoenzymatic synthesis of alpha-amino-beta-hydroxy-gamma-butyrolactone Tetrahedron Letters 1995 36:5063-5064 DOI:10.1016/00404-0399(50)09242-
- Garciajunceda, E., Shen, G. J., Sugai, T., Wong, C. H. A new strategy for the cloning, overexpression and one-step purification of 3 dhap-dependent aldolases - rhamnulose-1-phosphate aldolase, fuculose-1-phosphate aldolase and tagatose-1,6-diphosphate aldolase Bioorganic & Medicinal Chemistry 1995 3:945-953 DOI:10.1016/0968-0896(95)00077-t PMID:7582972
- Alajarin, R., Garciajunceda, E., Wong, C. H. A short enzymatic-synthesis of l-glucose from dihydroxyacetone phosphate and l-glyceraldehyde Journal of Organic Chemistry 1995 60:4294-4295 DOI:10.1021/jo00118a058
- Fitz, W., Schwark, J. R., Wong, C. H. Aldotetroses and c(3)-modified aldohexoses as substrates for n-acetylneuraminic acid aldolase - a model for the explanation of the normal and the inversed stereoselectivity Journal of Organic Chemistry 1995 60:3663-3670 DOI:10.1021/jo00117a016
- Vassilev, V. P., Uchiyama, T., Kajimoto, T., Wong, C. H. L-threonine aldolase in organic-synthesis - preparation of novel beta-hydroxy-alpha-amino acids Tetrahedron Letters 1995 36:4081-4084 DOI:10.1016/0040-4039(95)00720-w
- Deluca, C., Lansing, M., Martini, I., Crescenzi, F., Shen, G. J., Oregan, M., Wong, C. H. Enzymatic-synthesis of hyaluronic-acid with regeneration of sugar nucleotides Journal of the American Chemical Society 1995 117:5869-5870 DOI:10.1021/ja00126a034
- Huang, H. M., Wong, C. H. Synthesis of biologically-active sialyl-lewis-x mimetics Journal of Organic Chemistry 1995 60:3100-3106 DOI:10.1021/jo00115a027
- Uchiyama, T., Vassilev, V. P., Kajimoto, T., Wong, W. C., Huang, H. M., Lin, C. C., Wong, C. H. Design and synthesis of sialyl-Lewis X mimetics Journal of the American Chemical Society 1995 117:5395-5396 DOI:10.1021/ja00124a037
- Chou, W. C., Fotsch, C., Wong, C. H. Synthesis of nitrocyclitols based on enzymatic aldol reaction and intramolecular nitroaldol reaction Journal of Organic Chemistry 1995 60:2916-2917 DOI:10.1021/jo00114a051
- Stura, E. A., Ghosh, S., Garciajunceda, E., Chen, L. R., Wong, C. H., Wilson, I. A. Crystallization and preliminary crystallographic data for class-i deoxyribose-5-phosphate aldolase from escherichia-coli - an application of reverse screening Proteins-Structure Function and Genetics 1995 22:67-72 DOI:10.1002/prot.340220110 PMID:7675789
- Wang, P. G., Fitz, W., Wong, C. H. Making complex carbohydrates via enzymatic routes ChemTech 1995 25:22-32
- Wong, C. H., Garciajunceda, E., Chen, L. R., Blanco, O., Gijsen, H. J. M., Steensma, D. H. Recombinant 2-deoxyribose-5-phosphate aldolase in organic-synthesis - use of sequential 2-substrate and 3-substrate aldol reactions Journal of the American Chemical Society 1995 117:3333-3339 DOI:10.1021/ja00117a003
- Gijsen, H. J. M., Wong, C. H. Sequential one-pot aldol reactions catalyzed by 2-deoxyribose-5-phosphate aldolase and fructose-1,6-diphosphate aldolase Journal of the American Chemical Society 1995 117:2947-2948 DOI:10.1021/ja00115a038
- Wong, C. H., Halcomb, R. L., Ichikawa, Y., Kajimoto, T. Enzymes in organic-synthesis - application to the problems of carbohydrate-recognition .1 Angewandte Chemie-International Edition 1995 34:412-432 DOI:10.1002/anie.199504121
- Wong, C. H., Halcomb, R. L., Ichikawa, Y., Kajimoto, T. Enzymes in organic-synthesis - application to the problems of carbohydrate-recognition .2 Angewandte Chemie-International Edition 1995 34:521-546 DOI:10.1002/anie.199505211
- Sugai, T., Lin, C. H., Shen, G. J., Wong, C. H. CMP-KDO synthetase: overproduction and application to the synthesis of CMP-KDO and analogs Bioorganic & Medicinal Chemistry 1995 3:313-320 DOI:10.1016/0968-0896(95)00023-a PMID:7606392
- Ikeda, T., Kajimoto, T., Nohara, T., Kinjo, J., Wong, C. H. Preparation of a neoglycolipid carrying the oligosaccharide component of saponin from albizzia julibrissin Tetrahedron Letters 1995 36:1509-1510 DOI:10.1016/0040-4039(95)00072-k
- Defrees, S. A., Kosch, W., Way, W., Paulson, J. C., Sabesan, S., Halcomb, R. L., Huang, D. H., Ichikawa, Y., Wong, C. H. Ligand recognition by e-selectin - synthesis, inhibitory activity, and conformational-analysis of bivalent sialyl-lewis-x analogs Journal of the American Chemical Society 1995 117:66-79 DOI:10.1021/ja00106a008
- Hogg, J. H., Ollmann, I. R., Haeggstrom, J. Z., Wetterholm, A., Samuelsson, B., Wong, C. H. Amino hydroxamic acids as potent inhibitors of leukotriene A4 hydrolase Bioorganic & Medicinal Chemistry 1995 3:1405-1415 DOI:10.1016/0968-0896(95)00128-4 PMID:8564408
- Fang, J. M., Lin, C. H., Bradshaw, C. W., Wong, C. H. Enzymes in organic-synthesis - oxidoreductions Journal of the Chemical Society-Perkin Transactions 1 1995 967-978 DOI:10.1039/p19950000967
- Ollmann, I. R., Hogg, J. H., Munoz, B., Haeggstrom, J. Z., Samuelsson, B., Wong, C. H. Investigation of the inhibition of leukotriene A4 hydrolase Bioorganic & Medicinal Chemistry 1995 3:969-995 DOI:10.1016/0968-0896(95)00078-u PMID:7582974
- Wong, C. H., Provencher, L., Porco, J. A., Jung, S. H., Wang, Y. F., Chen, L. R., Wang, R., Steensma, D. H. Synthesis and evaluation of homoaza sugars as glycosidase inhibitors Journal of Organic Chemistry 1995 60:1492-1501 DOI:10.1021/jo00111a007
- Fitz, W., Wong, C. H. Combined use of subtilisin and n-acetylneuraminic acid aldolase for the synthesis of a fluorescent sialic-acid Journal of Organic Chemistry 1994 59:8279-8280 DOI:10.1021/jo00105a057
- Siuzdak, G., Zheng, Z. L., Rhamphal, J. Y., Ichikawa, Y., Nicolaou, K. C., Gaeta, F. C. A., Chatman, K. S., Wong, C. H. Examination of the sialyl-lewis-x calcium complex by electrospray mass-spectrometry Bioorganic & Medicinal Chemistry Letters 1994 4:2863-2866 DOI:10.1016/s0960-894x(01)80829-5
- Halcomb, R. L., Huang, H. M., Wong, C. H. Solution-phase and solid-phase synthesis of inhibitors of helicobacter-pylori attachment and e-selectin-mediated leukocyte adhesion Journal of the American Chemical Society 1994 116:11315-11322 DOI:10.1021/ja00104a011
- Halcomb, R. L., Fitz, W., Wong, C. H. Enzymatic-synthesis of 7-deoxy-n-acetylneuraminic acid and 7-o-methyl-n-acetylneuraminic acid Tetrahedron-Asymmetry 1994 5:2437-2442 DOI:10.1016/s0957-4166(00)80390-0
- Jung, S. H., Jeong, J. H., Miller, P., Wong, C. H. An efficient multigram-scale preparation of dihydroxyacetone phosphate Journal of Organic Chemistry 1994 59:7182-7184 DOI:10.1021/jo00102a060
- Yuasa, H., Kajimoto, T., Wong, C. H. Synthesis of iminothiasugar as a potential transition-state analog inhibitor of glycosyltransfer reactions Tetrahedron Letters 1994 35:8243-8246 DOI:10.1016/0040-4039(94)88293-2
- Herrmann, G. F., Wang, P., Shen, G. J., Garciajunceda, E., Khan, S. H., Matta, K. L., Wong, C. H. Large-scale production of recombinant alpha-1,2-mannosyltransferase from escherichia-coli for the study of acceptor specificity and use of the recombinant whole cells in synthesis Journal of Organic Chemistry 1994 59:6356-6362 DOI:10.1021/jo00100a043
- Gijsen, H. J. M., Wong, C. H. Unprecedented asymmetric aldol reactions with 3 aldehyde substrates catalyzed by 2-deoxyribose-5-phosphate aldolase Journal of the American Chemical Society 1994 116:8422-8423 DOI:10.1021/ja00097a082
- Marquardt, J. L., Brown, E. D., Lane, W. S., Haley, T. M., Ichikawa, Y., Wong, C. H., Walsh, C. T. Kinetics, stoichiometry, and identification of the reactive thiolate in the inactivation of udp-glcnac enolpyruvoyl transferase by the antibiotic fosfomycin Biochemistry 1994 33:10646-10651 DOI:10.1021/bi00201a011 PMID:8075065
- Sears, P., Schuster, M., Wang, P., Witte, K., Wong, C. H. Engineering subtilisin for peptide coupling - studies on the effects of counterions and site-specific modifications on the stability and specificity of the enzyme Journal of the American Chemical Society 1994 116:6521-6530 DOI:10.1021/ja00094a005
- Hiranuma, S., Kajimoto, T., Wong, C. H. A facile synthesis of 1-thiopentofuranoside Tetrahedron Letters 1994 35:5257-5260 DOI:10.1016/s0040-4039(00)77078-x
- Chou, W. C., Chen, L. H., Fang, J. M., Wong, C. H. A new route to deoxythiosugars based on aldolases Journal of the American Chemical Society 1994 116:6191-6194 DOI:10.1021/ja00093a018
- Fang, J. M., Wong, C. H. Enzymes in organic-synthesis - alteration of reversible-reactions to irreversible-processes Synlett 1994 393-402
- Fotsch, C. H., Wong, C. H. Synthesis of a guanidino-sugar as a glycosyl cation mimic Tetrahedron Letters 1994 35:3481-3484 DOI:10.1016/s0040-4039(00)73215-1
- Kondo, H., Aoki, S., Ichikawa, Y., Halcomb, R. L., Ritzen, H., Wong, C. H. Glycosyl phosphites as glycosylation reagents - scope and mechanism Journal of Organic Chemistry 1994 59:864-877 DOI:10.1021/jo00083a032
- Schuster, M., Wang, P., Paulson, J. C., Wong, C. H. Solid-phase chemical-enzymatic synthesis of glycopeptides and oligosaccharides Journal of the American Chemical Society 1994 116:1135-1136 DOI:10.1021/ja00082a047
- Ichikawa, Y., Halcomb, R. L., Wong, C. H. Sticky solutions Chemistry in Britain 1994 30:117-118, 120
- Henderson, I., Sharpless, K. B., Wong, C. H. Synthesis of carbohydrates via tandem use of the osmium-catalyzed asymmetric dihydroxylation and enzyme-catalyzed aldol addition-reactions Journal of the American Chemical Society 1994 116:558-561 DOI:10.1021/ja00081a016
- Henderson, I., Laslo, K., Wong, C. H. Chemoenzymatic synthesis of homoazasugars Tetrahedron Letters 1994 35:359-362 DOI:10.1016/0040-4039(94)85053-4
- Aoki, S., Kondo, H., Wong, C. H. Glycosyl phosphites as glycosylation reagents Neoglycoconjugates, Pt B 1994 247:193-211 PMID:7898353
- Herrmann, G. F., Wang, P., Shen, G. J., Wong, C. H. Recombinant whole cells as catalysts for the enzymatic-synthesis of oligosaccharides and glycopeptides Angewandte Chemie-International Edition 1994 33:1241-1242 DOI:10.1002/anie.199412411
- Ichikawa, Y., Wang, R., Wong, C. H. Regeneration of sugar nucleotide for enzymatic oligosaccharide synthesis Neoglycoconjugates, Pt B 1994 247:107-127 PMID:7898347
- Wang, Y. F., Takaoka, Y., Wong, C. H. Remarkable stereoselectivity in the inhibition of alpha-galactosidase from coffee bean by a new polyhydroxypyrrolidine inhibitor Angewandte Chemie-International Edition 1994 33:1242-1244 DOI:10.1002/anie.199412421
- Wang, P., Schuster, M., Wang, Y. F., Wong, C. H. Synthesis of phospholipid inhibitor conjugates by enzymatic transphosphatidylation with phospholipase-d Journal of the American Chemical Society 1993 115:10487-10491 DOI:10.1021/ja00076a004
- Halcomb, R. L., Wong, C. H. Synthesis of oligosaccharides, glycopeptides, and glycolipids Current Opinion in Structural Biology 1993 3:694-700 DOI:10.1016/0959-440x(93)90052-m
- Takaoka, Y., Kajimoto, T., Wong, C. H. Inhibition of n-acetylglucosaminyltransfer enzymes - chemical-enzymatic synthesis of new 5-membered acetamido azasugars Journal of Organic Chemistry 1993 58:4809-4812 DOI:10.1021/jo00070a013
- Defrees, S. A., Gaeta, F. C. A., Lin, Y. C., Ichikawa, Y., Wong, C. H. Ligand recognition by e-selectin - analysis of conformation and activity of synthetic monomeric and bivalent sialyl lewis-x analogs Journal of the American Chemical Society 1993 115:7549-7550 DOI:10.1021/ja00069a083
- Look, G. C., Ichikawa, Y., Shen, G. J., Cheng, P. W., Wong, C. H. A combined chemical and enzymatic strategy for the construction of carbohydrate-containing antigen core units Journal of Organic Chemistry 1993 58:4326-4330 DOI:10.1021/jo00068a030
- Wang, P., Shen, G. J., Wang, Y. F., Ichikawa, Y., Wong, C. H. Enzymes in oligosaccharide synthesis - active-domain overproduction, specificity study, and synthetic use of an alpha-1,2-mannosyltransferase with regeneration of gdp-man Journal of Organic Chemistry 1993 58:3985-3990 DOI:10.1021/jo00067a035
- Wong, C. H., Schuster, M., Wang, P., Sears, P. Enzymatic-synthesis of N-linked and O-linked glycopeptides Journal of the American Chemical Society 1993 115:5893-5901 DOI:10.1021/ja00067a001
- Herrmann, G. F., Ichikawa, Y., Wandrey, C., Gaeta, F. C. A., Paulson, J. C., Wong, C. H. A new multienzyme system for a one-pot synthesis of sialyl oligosaccharides - combined use of beta-galactosidase and alpha(2,6)-sialyltransferase coupled with regeneration insitu of cmp-sialic acid Tetrahedron Letters 1993 34:3091-3094 DOI:10.1016/s0040-4039(00)93387-2
- Sugai, T., Ritzen, H., Wong, C. H. Towards the chemoenzymatic synthesis of lipid-a Tetrahedron-Asymmetry 1993 4:1051-1058 DOI:10.1016/s0957-4166(00)80153-6
- Siuzdak, G., Ichikawa, Y., Caulfield, T. J., Munoz, B., Wong, C. H., Nicolaou, K. C. Evidence of ca2+-dependent carbohydrate association through ion spray mass-spectrometry Journal of the American Chemical Society 1993 115:2877-2881 DOI:10.1021/ja00060a040
- Wong, C. H. Development of enzymes for chemoenzymatic synthesis Chimia 1993 47:127-132
- Look, G. C., Fotsch, C. H., Wong, C. H. Enzyme-catalyzed organic-synthesis - practical routes to aza sugars and their analogs for use as glycoprocessing inhibitors Accounts of Chemical Research 1993 26:182-190 DOI:10.1021/ar00028a008
- Wong, C. H., Ichikawa, Y., Kajimoto, T., Liu, K. K. C., Shen, G. J., Lin, C. H., Wang, Y. F., Dumas, D. P., Lin, Y. C., Wang, R., Look, G. C. Practical synthesis of carbohydrates based on aldolases and glycosyl transferases Pure and Applied Chemistry 1993 65:803-808 DOI:10.1351/pac199365040803
- Sim, M. M., Kondo, H., Wong, C. H. Synthesis and use of glycosyl phosphites - an effective route to glycosyl phosphates, sugar nucleotides, and glycosides Journal of the American Chemical Society 1993 115:2260-2267 DOI:10.1021/ja00059a023
- Schuster, M., Munoz, B., Yuan, W., Wong, C. H. Papain-catalyzed synthesis of peptide isosteres Tetrahedron Letters 1993 34:1247-1250 DOI:10.1016/s0040-4039(00)91765-9
- Sugai, T., Shen, G. J., Ichikawa, Y., Wong, C. H. Synthesis of 3-deoxy-d-manno-2-octulosonic acid (kdo) and its analogs based on kdo aldolase-catalyzed reactions Journal of the American Chemical Society 1993 115:413-421 DOI:10.1021/ja00055a008
- Wei, Y. A., Munoz, B., Wong, C. H., Haeggstrom, J. Z., Wetterholm, A., Samuelsson, B. Development of selective tight-binding inhibitors of leukotriene-a4 hydrolase Journal of Medicinal Chemistry 1993 36:211-220 PMID:8423594
- Wang, Y. F., Dumas, D. P., Wong, C. H. Chemoenzymatic synthesis of 5-membered azasugars as inhibitors of fucosidase and fucosyl-transferase - an issue regarding the stereochemistry discrimination at transition-states Tetrahedron Letters 1993 34:403-406
- Wong, C. H., Liu, K. K. C., Kajimoto, T., Chen, L., Zhong, Z., Dumas, D. P., Liu, J. L. C., Ichikawa, Y. Enzymes for carbohydrate and peptide syntheses Indian Journal of Chemistry Section B-Organic Chemistry Including Medicinal Chemistry 1993 32:135-139
- Fu, H., Kondo, H., Ichikawa, Y., Look, G. C., Wong, C. H. Chloroperoxidase-catalyzed asymmetric-synthesis - enantioselective reactions of chiral hydroperoxides with sulfides and bromohydration of glycals Journal of Organic Chemistry 1992 57:7265-7270 DOI:10.1021/jo00052a048
- Lin, C. H., Sugai, T., Halcomb, R. L., Ichikawa, Y., Wong, C. H. Unusual stereoselectivity in sialic-acid aldolase-catalyzed aldol condensations - synthesis of both enantiomers of high-carbon monosaccharides Journal of the American Chemical Society 1992 114:10138-10145 DOI:10.1021/ja00052a008
- Wong, C. H., Liu, K. K. C., Kajimoto, T., Chen, L. R., Zhong, Z. Y., Ichikawa, Y., Shen, G. J. Developing better enzymes for organic-synthesis Annals of the New York Academy of Sciences 1992 672:343-351 DOI:10.1111/j.1749-6632.1992.tb35644.x PMID:1476380
- Ichikawa, Y., Lin, Y. C., Dumas, D. P., Shen, G. J., Garciajunceda, E., Williams, M. A., Bayer, R., Ketcham, C., Walker, L. E., Paulson, J. C., Wong, C. H. Chemical-enzymatic synthesis and conformational-analysis of sialyl lewis-x and derivatives Journal of the American Chemical Society 1992 114:9283-9298 DOI:10.1021/ja00050a007
- Kondo, H., Ichikawa, Y., Wong, C. H. Beta-sialyl phosphite and phosphoramidite - synthesis and application to the chemoenzymatic synthesis of cmp-sialic acid and sialyl oligosaccharides Journal of the American Chemical Society 1992 114:8748-8750 DOI:10.1021/ja00048a085
- Danishefsky, S. J., Gervay, J., Peterson, J. M., McDonald, F. E., Koseki, K., Oriyama, T., Griffith, D. A., Wong, C. H., Dumas, D. P. Remarkable regioselectivity in the chemical glycosylation of glycal acceptors - a concise solution to the synthesis of sialyl-lewis-x glycal Journal of the American Chemical Society 1992 114:8329-8331 DOI:10.1021/ja00047a077
- Liu, K. K. C., Wong, C. H. A new strategy for the synthesis of nucleoside analogs based on enzyme-catalyzed aldol reactions Journal of Organic Chemistry 1992 57:4789-4791 DOI:10.1021/jo00044a005
- Wong, C. H., Dumas, D. P., Ichikawa, Y., Koseki, K., Danishefsky, S. J., Weston, B. W., Lowe, J. B. Specificity, inhibition, and synthetic utility of a recombinant human alpha-1,3-fucosyl-transferase Journal of the American Chemical Society 1992 114:7321-7322 DOI:10.1021/ja00044a068
- Wong, C. H., Liu, K. K. C., Kajimoto, T., Chen, L. H., Zhong, Z. Y., Dumas, D. P., Liu, J. L. C., Ichikawa, Y. Enzymes for carbohydrate and peptide syntheses Pure and Applied Chemistry 1992 64:1197-1202 DOI:10.1351/pac199264081197
- Fernholz, E., Schloeder, D., Liu, K. K. C., Bradshaw, C. W., Huang, H. M., Janda, K., Lerner, R. A., Wong, C. H. Specificity of antibody-catalyzed transesterifications using enol esters - a comparison with lipase reactions Journal of Organic Chemistry 1992 57:4756-4761 DOI:10.1021/jo00043a042
- Yuan, W., Wong, C. H., Haeggstrom, J. Z., Wetterholm, A., Samuelsson, B. Novel tight-binding inhibitors of leukotriene-a(4) hydrolase Journal of the American Chemical Society 1992 114:6552-6553 DOI:10.1021/ja00042a041
- Look, G. C., Wong, C. H. A facile enzymatic-synthesis of gal-beta-1,3glucal - a key intermediate for the synthesis of le(a) and sialyl le(a) Tetrahedron Letters 1992 33:4253-4256 DOI:10.1016/s0040-4039(00)74231-6
- Liu, K. K. C., Wong, C. H. Enzymatic halohydration of glycals Journal of Organic Chemistry 1992 57:3748-3750 DOI:10.1021/jo00039a050
- Lin, Y. C., Hummel, C. W., Huang, D. H., Ichikawa, Y., Nicolaou, K. C., Wong, C. H. Conformational studies of sialyl lewis-x in aqueous-solution Journal of the American Chemical Society 1992 114:5452-5454 DOI:10.1021/ja00039a082
- Ichikawa, Y., Sim, M. M., Wong, C. H. Efficient chemical synthesis of gdp-fucose Journal of Organic Chemistry 1992 57:2943-2946 DOI:10.1021/jo00036a036
- Liu, J. L. C., Shen, G. J., Ichikawa, Y., Rutan, J. F., Zapata, G., Vann, W. F., Wong, C. H. Overproduction of cmp-sialic acid synthetase for organic-synthesis Journal of the American Chemical Society 1992 114:3901-3910 DOI:10.1021/ja00036a044
- Ichikawa, Y., Look, G. C., Wong, C. H. Enzyme-catalyzed oligosaccharide synthesis Analytical Biochemistry 1992 202:215-238 DOI:10.1016/0003-2697(92)90099-s PMID:1519746
- Ichikawa, Y., Look, G. C., Wong, C. H., Kajimoto, T. Synthesis of oligosaccharides using glycosyltransferases Journal of Synthetic Organic Chemistry Japan 1992 50:441-450
- Bradshaw, C. W., Lalonde, J. J., Wong, C. H. Enzymatic-synthesis of (r) and (s) 1-deuterohexanol Applied Biochemistry and Biotechnology 1992 33:15-24 DOI:10.1007/bf02922180 PMID:1416953
- Bradshaw, C. W., Fu, H., Shen, G. J., Wong, C. H. A pseudomonas sp alcohol-dehydrogenase with broad substrate-specificity and unusual stereospecificity for organic-synthesis Journal of Organic Chemistry 1992 57:1526-1532 DOI:10.1021/jo00031a036
- Bradshaw, C. W., Hummel, W., Wong, C. H. Lactobacillus-kefir alcohol-dehydrogenase - a useful catalyst for synthesis Journal of Organic Chemistry 1992 57:1532-1536 DOI:10.1021/jo00031a037
- Chen, L. R., Dumas, D. P., Wong, C. H. Deoxyribose-5-phosphate aldolase as a catalyst in asymmetric aldol condensation Journal of the American Chemical Society 1992 114:741-748 DOI:10.1021/ja00028a050
- Wong, C. H.*, Wang, R.*, Ichikawa, Y. Regeneration of sugar nucleotide for enzymic oligosaccharide synthesis: use of Gal-1-phosphate uridyltransferase in the regeneration of UDP-galactose, UDP-2-deoxygalactose, and UDP-galactosamine Journal of Organic Chemistry 1992 57:4343-4344 DOI:10.1021/jo00042a008 (* = equal contribution)
- Dumas, D. P., Kajimoto, T., Liu, K. K. C., Wong, C. H., Berkowitz, D. B., Danishefsky, S. J. Azasugar and glycal inhibitors of alpha-l-fucosidase Bioorganic & Medicinal Chemistry Letters 1992 2:33-36 DOI:10.1016/s0960-894x(00)80649-6
- Bradshaw, C. W., Shen, G. J., Wong, C. H. A new alcohol-dehydrogenase with unique stereospecificity from pseudomonas sp Bioorganic Chemistry 1991 19:398-417 DOI:10.1016/0045-2068(91)90022-h
- Wong, C. H., Wang, K. T. New developments in enzymatic peptide-synthesis Experientia 1991 47:1123-1129 DOI:10.1007/bf01918376 PMID:1765124
- Liu, K. K. C., Pederson, R. L., Wong, C. H. Fructose 1,6-diphosphate aldolase-catalyzed stereoselective c-c bond formation Journal of the Chemical Society-Perkin Transactions 1 1991 2669-2673 DOI:10.1039/p19910002669
- Liu, K. K. C., Kajimoto, T., Chen, L. R., Zhong, Z. Y., Ichikawa, Y., Wong, C. H. Use of dihydroxyacetone phosphate dependent aldolases in the synthesis of deoxyazasugars Journal of Organic Chemistry 1991 56:6280-6289 DOI:10.1021/jo00022a013
- Wong, C. H., Ichikawa, Y., Krach, T., Gautheronlenarvor, C., Dumas, D. P., Look, G. C. Probing the acceptor specificity of beta-1,4-galactosyltransferase for the development of enzymatic-synthesis of novel oligosaccharides Journal of the American Chemical Society 1991 113:8137-8145 DOI:10.1021/ja00021a045
- Gautheronlenarvor, C., Ichikawa, Y., Wong, C. H. A complete change of stereoselectivity in sialic-acid aldolase reactions - a novel synthetic route to the kdo type of 9-carbon-l sugars Journal of the American Chemical Society 1991 113:7816-7818 DOI:10.1021/ja00020a084
- Wong, C. H., Krach, T., Gautheronlenarvor, C., Ichikawa, Y., Look, G. C., Gaeta, F., Thompson, D., Nicolaou, K. C. Synthesis of novel disaccharides based on glycosyltransferases - beta-1,4galactosyltransferase Tetrahedron Letters 1991 32:4867-4870 DOI:10.1016/s0040-4039(00)93482-8
- Barbas, C. F., Wong, C. H. Overexpression and substrate-specificity studies of phosphodeoxyribomutase and thymidine phosphorylase Bioorganic Chemistry 1991 19:261-269 DOI:10.1016/0045-2068(91)90051-p
- Gautheronlenarvor, C., Wong, C. H. Glycosyltransferase-catalyzed stereoselective glycosidation of monosaccharide-based glycosidase inhibitors - a new approach to the synthesis of sequence-specific glycosidase inhibitors Journal of the Chemical Society-Chemical Communications 1991 1130-1131 DOI:10.1039/c39910001130
- Kajimoto, T., Chen, L. R., Liu, K. K. C., Wong, C. H. Palladium-mediated stereocontrolled reductive amination of azido sugars prepared from enzymatic aldol condensation - a general-approach to the synthesis of deoxy aza sugars Journal of the American Chemical Society 1991 113:6678-6680 DOI:10.1021/ja00017a052
- Ichikawa, Y., Liu, J. L. C., Shen, G. J., Wong, C. H. A highly efficient multienzyme system for the one-step synthesis of a sialyl trisaccharide - insitu generation of sialic-acid and n-acetyllactosamine coupled with regeneration of udp-glucose, udp-galactose, and cmp-sialic acid Journal of the American Chemical Society 1991 113:6300-6302 DOI:10.1021/ja00016a073
- Kajimoto, T., Liu, K. K. C., Pederson, R. L., Zhong, Z. Y., Ichikawa, Y., Porco, J. A., Wong, C. H. Enzyme-catalyzed aldol condensation for asymmetric-synthesis of azasugars - synthesis, evaluation, and modeling of glycosidase inhibitors Journal of the American Chemical Society 1991 113:6187-6196 DOI:10.1021/ja00016a039
- Fu, H., Newcomb, M., Wong, C. H. Pseudomonas-oleovorans monooxygenase catalyzed asymmetric epoxidation of allyl alcohol derivatives and hydroxylation of a hypersensitive radical probe with the radical ring-opening rate exceeding the oxygen rebound rate Journal of the American Chemical Society 1991 113:5878-5880 DOI:10.1021/ja00015a061
- Drueckhammer, D. G., Hennen, W. J., Pederson, R. L., Barbas, C. F., Gautheron, C. M., Krach, T., Wong, C. H. Enzyme catalysis in synthetic carbohydrate-chemistry Synthesis-Stuttgart 1991 499-525
- Nicolaou, K. C., Hummel, C. W., Bockovich, N. J., Wong, C. H. Stereocontrolled synthesis of sialyl lex, the oligosaccharide binding ligand to elam-1 (sialyl = n-acetylneuramin) Journal of the Chemical Society-Chemical Communications 1991 870-872 DOI:10.1039/c39910000870
- Ichikawa, Y., Shen, G. J., Wong, C. H. Enzyme-catalyzed synthesis of sialyl oligosaccharide with insitu regeneration of cmp-sialic acid Journal of the American Chemical Society 1991 113:4698-4700 DOI:10.1021/ja00012a058
- Fu, H., Shen, G. J., Wong, C. H. Asymmetric epoxidation of allyl alcohol derivatives by omega-hydroxylase from Pseudomonas oleovorans Recueil des Travaux Chimiques des Pays-Bas 1991 110:167-170 DOI:10.1002/recl.19911100506
- Pederson, R. L., Esker, J., Wong, C. H. An improved synthesis of dihydroxyacetone phosphate Tetrahedron 1991 47:2643-2648 DOI:10.1016/s0040-4020(01)81796-8
- Zhong, Z., Bibbs, J. A., Yuan, W., Wong, C. H. Active-site-directed modification of subtilisin Journal of the American Chemical Society 1991 113:2259-2263 DOI:10.1021/ja00006a052
- Bradshaw, C. W., Wong, C. H., Hummel, W., Kula, M. R. Enzyme-catalyzed asymmetric-synthesis of (s)-2-amino-4-phenylbutanoic acid and (r)-2-hydroxy-4-phenylbutanoic acid Bioorganic Chemistry 1991 19:29-39 DOI:10.1016/0045-2068(91)90041-m
- Zhong, Z. Y., Liu, J. L. C., Dinterman, L. M., Finkelman, M. A. J., Mueller, W. T., Rollence, M. L., Whitlow, M., Wong, C. H. Engineering subtilisin for reaction in dimethylformamide Journal of the American Chemical Society 1991 113:683-684 DOI:10.1021/ja00002a051
- Wong, C. H. Aldolases in synthesis of fluorosugars ACS Symposium Series 1991 456:156-162 DOI:10.1021/bk-1991-0456.ch010
- Zhong, Z. Y., Wong, C. H. Development of new enzymatic catalysts for peptide-synthesis in aqueous and organic-solvents Biomedica Biochimica Acta 1991 50:S9-S14 PMID:1820067
- Wong, C. H., Shen, G. J., Pederson, R. L., Wang, Y. F., Hennen, W. J. Enzymatic catalysis in organic-synthesis Methods in Enzymology 1991 202:591-620 DOI:10.1016/0076-6879(91)02028-8 PMID:1784190
- Dumas, D. P., Ichikawa, Y., Wong, C. H., Lowe, J. B., Nair, R. P. Enzymatic-synthesis of sialyl lex and derivatives based on a recombinant fucosyl-transferase Bioorganic & Medicinal Chemistry Letters 1991 1:425-428 DOI:10.1016/s0960-894x(00)80270-x
- Wong, C. H. Microbial aldolases in carbohydrate synthesis ACS Symposium Series 1991 466:23-37 DOI:10.1021/bk-1991-0466.ch002
- Yuan, W., Zhong, Z., Wong, C. H. Probing the inhibition of leukotriene-a4 hydrolase based on its aminopeptidase activity Bioorganic & Medicinal Chemistry Letters 1991 1:551-556 DOI:10.1016/s0960-894x(01)80464-9
- Vonderosten, C. H., Gioannetti, C., Barbas, C., Pederson, R. L., Wang, Y. F., Wong, C. H., Ozaki, A., Toone, E., Whitesides, G. M., Sinskey, A. J. Molecular-cloning of aldolases for synthetic applications Annals of the New York Academy of Sciences 1990 613:771-775 PMID:2076016
- Pederson, R. L., Liu, K. K. C., Rutan, J. F., Chen, L., Wong, C. H. Enzymes in organic-synthesis - synthesis of highly enantiomerically pure 1,2-epoxy aldehydes, epoxy alcohols, thiirane, aziridine, and glyceraldehyde-3-phosphate Journal of Organic Chemistry 1990 55:4897-4901 DOI:10.1021/jo00303a026
- West, J. B., Hennen, W. J., Lalonde, J. L., Bibbs, J. A., Zhong, Z. Y., Meyer, E. F., Wong, C. H. Enzymes as synthetic catalysts - mechanistic and active-site considerations of natural and modified chymotrypsin Journal of the American Chemical Society 1990 112:5313-5320 DOI:10.1021/ja00169a043
- Babiak, K. A., Ng, J. S., Dygos, J. H., Weyker, C. L., Wang, Y. F., Wong, C. H. Lipase-catalyzed irreversible transesterification using enol esters - resolution of prostaglandin synthons 4-hydroxy-2-alkyl-2-cyclopentenones and inversion of the 4s enantiomer to the 4r enantiomer Journal of Organic Chemistry 1990 55:3377-3381 DOI:10.1021/jo00297a073
- Shen, G. J., Wang, Y. F., Bradshaw, C., Wong, C. H. A new nad-dependent alcohol-dehydrogenase with opposite facial selectivity useful for asymmetric reduction and cofactor regeneration Journal of the Chemical Society-Chemical Communications 1990 677-679 DOI:10.1039/c39900000677
- Barbas, C. F., Wang, Y. F., Wong, C. H. Deoxyribose-5-phosphate aldolase as a synthetic catalyst Journal of the American Chemical Society 1990 112:2013-2014 DOI:10.1021/ja00161a064
- Wong, C. H., Chen, S. T., Hennen, W. J., Bibbs, J. A., Wang, Y. F., Liu, J. L. C., Pantoliano, M. W., Whitlow, M., Bryan, P. N. Enzymes in organic synthesis: use of subtilisin and a highly stable mutant derived from multiple site-specific mutations Journal of the American Chemical Society 1990 112:945-953 DOI:10.1021/ja00159a006
- Hsu, S. H., Wu, S. S., Wang, Y. F., Wong, C. H. Lipase-catalyzed irreversible transesterification using enol esters - xad-8 immobilized lipoprotein lipase-catalyzed resolution of secondary alcohols Tetrahedron Letters 1990 31:6403-6406 DOI:10.1016/s0040-4039(00)97076-x
- Vonderosten, C. H., Barbas, C. F., Wong, C. H., Sinskey, A. J. Molecular-cloning, nucleotide-sequence and fine-structural analysis of the corynebacterium-glutamicum fda gene - structural comparison of corynebacterium-glutamicum fructose-1,6-biphosphate aldolase to class-i and class-ii aldolases Molecular Microbiology 1989 3:1625-1637 PMID:2615658
- Wang, Y. F., Wong, C. H. Enantioselective syntheses of platelet-activating factor and a phospholipase-a2 inhibitor from chiral synthons prepared enzymatically Journal of the Chinese Chemical Society 1989 36:463-468
- Chen, S. T., Wong, C. H. Studies on angiotensin-converting enzyme-inhibitors - protease catalyzed resolution of aryl 3-mercapto-2-methylpropionic ester Journal of the Chinese Chemical Society 1989 36:451-458
- Hennen, W. J., Wong, C. H. A new method for the enzymatic-synthesis of nucleosides using purine nucleoside phosphorylase Journal of Organic Chemistry 1989 54:4692-4695 DOI:10.1021/jo00280a046
- Wong, C. H. Enzymatic catalysts in organic-synthesis Science 1989 244:1145-1152 DOI:10.1126/science.2658059 PMID:2658059
- Vonderosten, C. H., Sinskey, A. J., Barbas, C. F., Pederson, R. L., Wang, Y. F., Wong, C. H. Use of a recombinant bacterial fructose-1,6-diphosphate aldolase in aldol reactions - preparative syntheses of 1-deoxynojirimycin, 1-deoxymannojirimycin, 1,4-dideoxy-1,4-imino-d-arabinitol, and fagomine Journal of the American Chemical Society 1989 111:3924-3927 DOI:10.1021/ja00193a025
- Drueckhammer, D. G., Durrwachter, J. R., Pederson, R. L., Crans, D. C., Daniels, L., Wong, C. H. Reversible and insitu formation of organic arsenates and vanadates as organic phosphate mimics in enzymatic-reactions - mechanistic investigation of aldol reactions and synthetic applications Journal of Organic Chemistry 1989 54:70-77 DOI:10.1021/jo00262a021
- Pederson, R. L., Wong, C. H. Enzymatic aldol condensation as a route to heterocycles: synthesis of 1,4-dideoxy-1,4-imino-D-arabinitol, fagomine, 1-deoxynojirimycin and 1-deoxymannojirimycin Heterocycles 1989 28:477-480 DOI:10.3987/COM-88-S99
- Wong, C. H., Drueckhammer, D. G., Durrwachter, J. R., Lacher, B., Chauvet, C. J., Wang, Y. F., Sweers, H. M., Smith, G. L., Yang, L. J. S., Hennen, W. J. Enzyme-catalyzed synthesis of carbohydrates ACS Symposium Series 1989 386:317-335 DOI:10.1021/bk-1989-0386.ch018
- Wang, Y. F., Chen, S. T., Liu, K. K. C., Wong, C. H. Lipase-catalyzed irreversible trans-esterification using enol esters - resolution of cyanohydrins and syntheses of ethyl (r)-2-hydroxy-4-phenylbutyrate and (s)-propranolol Tetrahedron Letters 1989 30:1917-1920 DOI:10.1016/s0040-4039(00)99613-8
- Hennen, W. J., Sweers, H. M., Wang, Y. F., Wong, C. H. Enzymes in carbohydrate synthesis - lipase-catalyzed selective acylation and deacylation of furanose and pyranose derivatives Journal of Organic Chemistry 1988 53:4939-4945 DOI:10.1021/jo00256a008
- Wang, Y. F., Lalonde, J. J., Momongan, M., Bergbreiter, D. E., Wong, C. H. Lipase-catalyzed irreversible transesterifications using enol esters as acylating reagents - preparative enantioselective and regioselective syntheses of alcohols, glycerol derivatives, sugars, and organometallics Journal of the American Chemical Society 1988 110:7200-7205 DOI:10.1021/ja00229a041
- Kim, M. J., Hennen, W. J., Sweers, H. M., Wong, C. H. Enzymes in carbohydrate synthesis - n-acetylneuraminic acid aldolase catalyzed-reactions and preparation of n-acetyl-2-deoxy-d-neuraminic acid-derivatives Journal of the American Chemical Society 1988 110:6481-6486 DOI:10.1021/ja00227a031
- Durrwachter, J. R., Wong, C. H. Fructose 1,6-diphosphate aldolase catalyzed stereoselective synthesis of c-alkyl and n-containing sugars - thermodynamically controlled c-c bond formations Journal of Organic Chemistry 1988 53:4175-4181 DOI:10.1021/jo00253a004
- Barbas, C. F., Matos, J. R., West, J. B., Wong, C. H. A search for peptide ligase: cosolvent-mediated conversion of proteases to esterases for irreversible synthesis of peptides Journal of the American Chemical Society 1988 110:5162-5166 DOI:10.1021/ja00223a042
- West, J. B., Scholten, J., Stolowich, N. J., Hogg, J. L., Scott, A. I., Wong, C. H. Modification of proteases to esterases for peptide-synthesis - methylchymotrypsin Journal of the American Chemical Society 1988 110:3709-3710 DOI:10.1021/ja00219a083
- Lalonde, J. J., Bergbreiter, D. E., Wong, C. H. Enzymatic kinetic resolution of alpha-nitro alpha-methyl carboxylic-acids Journal of Organic Chemistry 1988 53:2323-2327 DOI:10.1021/jo00245a036
- Drueckhammer, D. G., Barbas, C. F., Nozaki, K., Wong, C. H., Wood, C. Y., Ciufolini, M. A. Chemoenzymic synthesis of chiral furan-derivatives - useful building-blocks for optically-active structures Journal of Organic Chemistry 1988 53:1607-1611 DOI:10.1021/jo00243a003
- Pederson, R. L., Kim, M. J., Wong, C. H. A combined chemical and enzymatic procedure for the synthesis of 1-deoxynojirimycin and 1-deoxymannojirimycin Tetrahedron Letters 1988 29:4645-4648 DOI:10.1016/s0040-4039(00)80570-5
- Wong, C. H., Dreckhammer, D. G., Sweers, H. M. Chemoenzymatic synthesis of fluorosugars ACS Symposium Series 1988 374:29-42 DOI:10.1021/bk-1988-0374.ch003
- Barbas, C. F., Wong, C. H. One-pot tripeptide syntheses from 3 single amino-acid derivatives catalyzed by papain Tetrahedron Letters 1988 29:2907-2910 DOI:10.1016/0040-4039(88)85044-5
- Drueckhammer, D. G., Sadozai, S. K., Wong, C. H., Roberts, S. M. Biphasic one-pot synthesis of two useful and separable compounds using nicotinamide cofactor-requiring enzymes: syntheses of (S)-4-hydroxyhexanoate and its lactone Enzyme and Microbial Technology 1987 9:564-570 DOI:10.1016/0141-0229(87)90089-5
- Barbas, C. F., Wong, C. H. Papain catalyzed peptide-synthesis - control of amidase activity and the introduction of unusual amino-acids Journal of the Chemical Society-Chemical Communications 1987 533-534 DOI:10.1039/c39870000533
- Matos, J. R., West, J. B., Wong, C. H. Lipase catalyzed synthesis of peptides - preparation of a penicillin-g precursor and other peptides Biotechnology Letters 1987 9:233-236 DOI:10.1007/bf01027155
- Matos, J. R., Wong, C. H. S-adenosylmethionine - stability and stabilization Bioorganic Chemistry 1987 15:71-80 DOI:10.1016/0045-2068(87)90008-3
- Matos, J. R., Raushel, F. M., Wong, C. H. S-adenosylmethionine - studies on chemical and enzymatic-synthesis Biotechnology and Applied Biochemistry 1987 9:39-52 PMID:3566918
- Crans, D. C., Kazlauskas, R. J., Hirschbein, B. L., Wong, C. H., Abril, O., Whitesides, G. M. Enzymatic regeneration of adenosine 5'-triphosphate: acetyl phosphate, phosphoenolpyruvate, methoxycarbonyl phosphate, dihydroxyacetone phosphate, 5-phospho-alpha-D-ribosyl pyrophosphate, uridine-5'-diphosphoglucose Methods in Enzymology 1987 136:263-280 DOI:10.1016/S0076-6879(87)36027-6 PMID:2446104
- West, J. B., Wong, C. H. Use of nonproteases in peptide-synthesis Tetrahedron Letters 1987 28:1629-1632 DOI:10.1016/s0040-4039(00)95377-2
- Durrwachter, J. R., Drueckhammer, D. G., Nozaki, K., Sweers, H. M., Wong, C. H. Enzymatic aldol condensation isomerization as a route to unusual sugar-derivatives Journal of the American Chemical Society 1986 108:7812-7818 DOI:10.1021/ja00284a053 PMID:22283291
- Chen, S. T., Wang, K. T., Wong, C. H. Chirally selective hydrolysis of d,l-amino acid-esters by alkaline protease Journal of the Chemical Society-Chemical Communications 1986 1514-1516 DOI:10.1039/c39860001514
- Sweers, H. M., Wong, C. H. Enzyme-catalyzed regioselective deacylation of protected sugars in carbohydrate synthesis Journal of the American Chemical Society 1986 108:6421-6422 DOI:10.1021/ja00280a068
- West, J. B., Wong, C. H. Enzyme-catalyzed irreversible formation of peptides containing d-amino acids Journal of Organic Chemistry 1986 51:2728-2735 DOI:10.1021/jo00364a021
- Matos, J. R., Wong, C. H. Biphasic one-pot synthesis of 2 useful and separable compounds using cofactor-requiring enzymatic-reactions - glutamate-dehydrogenase catalyzed synthesis of l-alpha-aminoadipate coupled with alcohol-dehydrogenase catalyzed synthesis of a chiral lactone Journal of Organic Chemistry 1986 51:2388-2389 DOI:10.1021/jo00362a045
- West, J. B., Wong, C. H. Enzyme-catalyzed synthesis of peptides containing d-amino acids Journal of the Chemical Society-Chemical Communications 1986 417-418 DOI:10.1039/c39860000417
- Durrwachter, J. R., Sweers, H. M., Nozaki, K., Wong, C. H. Enzymatic aldol reaction isomerization as a route to unusual sugars Tetrahedron Letters 1986 27:1261-1264 DOI:10.1016/s0040-4039(00)84233-1
- Drueckhammer, D. G., Riddle, V. W., Wong, C. H. Fmn reductase catalyzed regeneration of nad(p) for use in enzymatic-synthesis Journal of Organic Chemistry 1985 50:5387-5389 DOI:10.1021/jo00225a080
- Wong, C. H., Matos, J. R. Enantioselective oxidation of 1,2-diols to l-alpha-hydroxy acids using coimmobilized alcohol and aldehyde dehydrogenases as catalysts Journal of Organic Chemistry 1985 50:1992-1994 DOI:10.1021/jo00211a046
- Matos, J. R., Smith, M. B., Wong, C. H. Enantioselectivity of alcohol dehydrogenase-catalyzed oxidation of 1,2-diols and aminoalcohols Bioorganic Chemistry 1985 13:121-130 DOI:10.1016/0045-2068(85)90014-8
- Wong, C. H., Drueckhammer, D. G. Enzymatic synthesis of chiral hydroxy compounds using immobilized glucose dehydrogenase from Bacillus cereus for NAD(P)H regeneration Bio-Technology 1985 3:649-651 DOI:10.1038/nbt0785-649
- Wong, C. H., Drueckhammer, D. G., Sweers, H. M. Enzymatic vs fermentative synthesis - thermostable glucose-dehydrogenase catalyzed regeneration of nad(p)h for use in enzymatic-synthesis Journal of the American Chemical Society 1985 107:4028-4031 DOI:10.1021/ja00299a044
- Root, R. L., Durrwachter, J. R., Wong, C. H. Enzymatic-synthesis of unusual sugars - galactose-oxidase catalyzed stereospecific oxidation of polyols Journal of the American Chemical Society 1985 107:2997-2999 DOI:10.1021/ja00296a041
- Whitesides, G. M., Wong, C. H. Enzymes as catalysts in synthetic organic-chemistry Angewandte Chemie-International Edition 1985 24:617-638 DOI:10.1002/anie.198506173
- Wong, C. H., Mazenod, F. P., Whitesides, G. M. Chemical and enzymatic syntheses of 6-deoxyhexoses - conversion to 2,5-dimethyl-4-hydroxy-2,3-dihydrofuran-3-one (furaneol) and analogs Journal of Organic Chemistry 1983 48:3493-3497 DOI:10.1021/jo00168a023
- Wong, C. H., Whitesides, G. M. Enzyme-catalyzed organic-synthesis - regeneration of deuterated nicotinamide cofactors for use in large-scale enzymatic-synthesis of deuterated substances Journal of the American Chemical Society 1983 105:5012-5014 DOI:10.1021/ja00353a026
- Wong, C. H., Haynie, S. L., Whitesides, G. M. Preparation of a mixture of nucleoside triphosphates from yeast rna - use in enzymatic-synthesis requiring nucleoside triphosphate regeneration and conversion to nucleoside diphosphate sugars Journal of the American Chemical Society 1983 105:115-117 DOI:10.1021/ja00339a021
- Wong, C. H., Whitesides, G. M. Synthesis of sugars by aldolase-catalyzed condensation-reactions Journal of Organic Chemistry 1983 48:3199-3205 DOI:10.1021/jo00167a012
- Whitesides, G. M., Wong, C. H., Pollak, A. Asymmetric synthesis using cofactor-requiring enzymes ACS Symposium Series 1982 185:205-218 DOI:10.1021/bk-1982-0185.ch015
- Wong, C. H., Haynie, S. L., Whitesides, G. M. Enzyme-catalyzed synthesis of n-acetyllactosamine with insitu regeneration of uridine 5'-diphosphate glucose and uridine 5'-diphosphate galactose Journal of Organic Chemistry 1982 47:5416-5418 DOI:10.1021/jo00148a045
- Wong, C. H., Whitesides, G. M. Enzyme-catalyzed transhydrogenation between nicotinamide cofactors and its application in organic-synthesis Journal of the American Chemical Society 1982 104:3542-3544 DOI:10.1021/ja00376a067
- Wong, C. H., Pollak, A., McCurry, S. D., Sue, J. M., Knowles, J. R., Whitesides, G. M. Synthesis of ribulose 1,5-bisphosphate - routes from glucose-6-phosphate (via 6-phosphogluconate) and from adenosine-monophosphate (via ribose 5-phosphate) Methods in Enzymology 1982 89:108-121 PMID:7144568
- Dicosimo, R., Wong, C. H., Daniels, L., Whitesides, G. M. Enzyme-catalyzed organic synthesis: electrochemical regeneration of NAD(P)H from NAD(P) using methyl viologen and flavoenzymes Journal of Organic Chemistry 1981 46:4622-4623 DOI:10.1021/jo00335a078
- Wong, C. H., Whitesides, G. M. Enzyme-catalyzed organic-synthesis - nad(p)h cofactor regeneration by using glucose-6-phosphate and the glucose-6-phosphate-dehydrogenase from leuconostoc-mesenteroides Journal of the American Chemical Society 1981 103:4890-4899 DOI:10.1021/ja00406a037
- Wong, C. H., Daniels, L., Ormejohnson, W. H., Whitesides, G. M. Enzyme-catalyzed organic-synthesis - nad(p)h regeneration using dihydrogen and the hydrogenase from methanobacterium-thermoautotrophicum Journal of the American Chemical Society 1981 103:6227-6228 DOI:10.1021/ja00410a049
- Wong, C. H., Gordon, J., Cooney, C. L., Whitesides, G. M. Regeneration of nad(p)h using glucose 6-sulfate and glucose-6-phosphate-dehydrogenase Journal of Organic Chemistry 1981 46:4676-4679 DOI:10.1021/jo00336a009
- Wong, C. H., McCurry, S. D., Whitesides, G. M. Practical enzymatic syntheses of ribulose 1,5-bisphosphate and ribose 5-phosphate Journal of the American Chemical Society 1980 102:7938-7939 DOI:10.1021/ja00547a023
- Chou, S. H., Wong, C. H., Chen, S. T., Wang, K. T. Enzymatic-synthesis of oligopeptide .2. Synthesis of bis-(n-protected amino-acid) hydrazides by papain Journal of the Chinese Chemical Society 1979 26:11-15
- Wong, C. H., Chen, S. T., Wang, K. T. Enzymic-synthesis of opioid peptides Biochimica et Biophysica Acta 1979 576:247-249 DOI:10.1016/0005-2795(79)90500-2 PMID:760808
- Wong, C. H. Resolution of rs-mandelic acid Journal of the Chinese Chemical Society 1979 26:75-78
- Wong, C. H., Wang, K. T. Electrochemistry in organic-synthesis .1. Large-scale preparation of cysteine from cystine Journal of the Chinese Chemical Society 1978 25:149-151
- Chou, S. H., Chen, S. T., Wong, C. H., Wang, K. T. Enzymatic-synthesis of oligopeptide .1. Papain-catalyzed synthesis of dipeptide, tripeptide and tetrapeptide Journal of the Chinese Chemical Society 1978 25:215-218
- Wong, C. H., Wang, K. T. Mutual resolution of (+)-ephedrine and z-dl-amino acid-induced by seeding chiral salt Tetrahedron Letters 1978 3813-3816
- Wong, C. H., Wang, K. T. Mutual resolution of dl-ephedrine and n-benzyloxycarbonyl-dl-amino acids Journal of the Chinese Chemical Society 1978 25:209-214
- Wong, C. H., Ho, M. F., Wang, K. T. Preparation of optically pure n-tert-butyloxycarbonyl-o-benzyl-l-serine and its antipode Journal of Organic Chemistry 1978 43:3604-3604 DOI:10.1021/jo00412a042
- Wong, C. H., Ho, C. L., Wang, K. T. Purification of synthetic cardiotoxin by affinity chromatography Journal of Chromatography 1978 154:25-32 PMID:670366
- Wong, C. H., Chen, Y. H., Hung, M. C., Wang, K. T., Ho, C. L., Lo, T. B. Renaturation of a reduced taiwan cobra cardiotoxin Biochimica et Biophysica Acta 1978 533:105-111 DOI:10.1016/0005-2795(78)90553-6 PMID:76481
- Wong, C. H., Chen, S. T., Ho, C. L., Wang, K. T. Synthesis of a fully active snake-venom cardiotoxin by fragment condensation on solid polymer Biochimica et Biophysica Acta 1978 536:376-389 DOI:10.1016/0005-2795(78)90496-8 PMID:81691
- Wong, C. H., Chen, S. T., Wang, K. T. Resolution of amino-acids by enzymes .1. Proteolytic-enzyme bromelain for hydrolysis of l-amino-acid methyl-esters Journal of the Chinese Chemical Society 1977 24:129-133
- Kong, F. T., Lin, T. C., Wong, C. H., Wang, K. T. Synthesis of taiwan cobra venom cardiotoxin .2. Synthesis of protected hexapeptide, sequence 44-49 and protected tripeptide, sequence 50-52 Journal of the Chinese Chemical Society 1976 23:155-164
chapter
- Calarese, D., Scanlan, C., Lee, H. K., Rudd, P., Dwek, R. Toward a carbohydrate-based HIV-1 vaccine ACS Symposium Series. 161-185. 2006 DOI:10.1021/bk-2006-0932.ch007

Scripps VIVO

Wong, Chi-Huey

Positions

Research Areas

Contact

Websites

Publications

h-index

recent publications

All Publications

PubMed Display for Export

Publications without PubMed PMIDs

academic article

chapter

featured in

Research

research overview

Teaching

advisees

graduate advising relationship

postdoc or fellow advising relationship

Background

education and training

awards and honors

Contact

full name

geographic location

Positions

Research Areas

Contact

Websites

Publications

h-index

recent publications All Publications PubMed Display for Export Publications without PubMed PMIDs

academic article

chapter

featured in

Research

research overview

Teaching

advisees

graduate advising relationship

postdoc or fellow advising relationship

Background

education and training

awards and honors

Contact

full name

geographic location

recent publications

All Publications

PubMed Display for Export

Publications without PubMed PMIDs