Dr. Chi-Huey Wong directed toward development of new tools for understanding the role of biological glycosylation in cancer progression, bacterial and viral infection, neurodegenerative disorder and immune response. The tools being developed include chemical and enzymatic synthesis of oligosaccharides glycoproteins; the design and synthesis of mechanism-based inhibitors of enzymes or receptors; the study of carbohydrate-based biological recognition and its intervention; and the investigation of reaction mechanisms.
Wong, C. H., Liu, K. K. C., Kajimoto, T., Chen, L., Zhong, Z., Dumas, D. P., Liu, J. L. C., Ichikawa, Y.
Enzymes for carbohydrate and peptide synthesesIndian Journal of Chemistry Section B-Organic Chemistry Including Medicinal Chemistry1993
Research in the Wong lab encompasses a broad spectrum of bioorganic and synthetic chemistry. Development of small molecules targeting RNA and design and synthesis of inhibitors to enzymes and receptors are being performed to investigate how small molecules interact with biologically important molecules and in turn, learn more about the function of those molecules. Development of both synthetic and bioorganic strategies is also paramount to our research. Programmable one-pot reactions can be used for the synthesis of complex oligosaccharides and glycoarrays, and compliment development of new enzymatic catalysts for glycoprotein synthesis and other organic reactions.