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Wong, Chi-Huey
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Wong, Chi-Huey

Faculty Member
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Positions

  • 2019 - Scripps Family Chair Professor, Chemistry , Scripps Research
  • 2016 - Distinguished Research Fellow, Genomics Research Center, Academia Sinica
  • 2007 - Distinguished Professor of Chemistry, National Tsing Hua University
  • 2006 - Distinguished Professor of Chemistry and Biochemical Sciences, National Taiwan University
  • 2006 - 2019 Professor of Chemistry, Chemistry , Scripps Research
  • 2006 - 2016 President, Academia Sinica
  • 1996 - 2006 Member, The Skaggs Institute for Chemical Biology , Scripps Research
  • 1989 - 2006 Ernest W. Hahn Professor of Chemistry, Chemistry , Scripps Research
  • 1989 - 2006 Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
  • 1991 - 1999 Head, Frontier Research Program on Glycotechnology, RIKEN: Institute of Physical and Chemical Research
  • 1987 - 1989 Professor of Chemistry, Texas A&M University
  • 1987 - 1989 Professor, Department of Biochemistry and Biophysics and the Institute of Biosciences and Technology, Texas A&M University
  • 1986 - 1987 Associate Professor of Chemistry, Texas A&M University
  • 1983 - 1986 Assistant Professor of Chemistry, Texas A&M University
  • 1982 - 1983 Postdoctoral Fellow with G.M. Whitesides, Harvard University
Dr. Chi-Huey Wong directed toward development of new tools for understanding the role of biological glycosylation in cancer progression, bacterial and viral infection, neurodegenerative disorder and immune response. The tools being developed include chemical and enzymatic synthesis of oligosaccharides glycoproteins; the design and synthesis of mechanism-based inhibitors of enzymes or receptors; the study of carbohydrate-based biological recognition and its intervention; and the investigation of reaction mechanisms.

Research Areas research areas

  • Arthritis (UMLS)
  • Glycoproteins (LCSH)
  • Oligosaccharides (LCSH)

Contact

  • wong@scripps.edu

Websites

  • Wong Laboratory website
  • Publications
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Publications

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  • 119

recent publications
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    • Liao, H. Y., Wang, S. C., Ko, Y. A., Lin, K. I., Ma, C., Cheng, T. J. R., Wong, C. H. Chimeric hemagglutinin vaccine elicits broadly protective CD4 and CD8 T cell responses against multiple influenza strains and subtypes Proceedings of the National Academy of Sciences of the United States of America  2020 117:17757-17763  DOI:10.1073/pnas.2004783117  PMID:32669430  PMCID:PMC7395492
    • Dey, S., Lo, H. J., Wong, C. H. Programmable One-Pot Synthesis of Heparin Pentasaccharide Fondaparinux Organic Letters  2020 22:4638-4642  DOI:10.1021/acs.orglett.0c01386  PMID:32496799  PMCID:PMC7347301
    • Chiu, L. T., Sabbavarapu, N. M., Lin, W. C., Fan, C. Y., Wu, C. C., Cheng, T. J. R., Wong, C. H., Hung, S. C. Trisaccharide Sulfate and Its Sulfonamide as an Effective Substrate and Inhibitor of Human Endo-O-sulfatase-1 Journal of the American Chemical Society  2020 142:5282-5292  DOI:10.1021/jacs.0c00005  PMID:32083852
    • Woodring, J. L., Lu, S. H., Krasnova, L., Wang, S. C., Chen, J. B., Chou, C. C., Huang, Y. C., Cheng, T. J. R., Wu, Y. T., Chen, Y. H., Fang, J. M., Tsai, M. D., et al. Disrupting the conserved salt bridge in the trimerization of influenza A nucleoprotein Journal of Medicinal Chemistry  2020 63:205-215  DOI:10.1021/acs.jmedchem.9b01244  PMID:31769665
    • Wang, E. A., Chen, W. Y., Wong, C. H. Multiple Growth Factor Targeting by Engineered Insulin-like Growth Factor Binding Protein-3 Augments EGF Receptor Tyrosine Kinase Inhibitor Efficacy Scientific Reports  2020 10  DOI:10.1038/s41598-020-59466-6  PMID:32066763  PMCID:PMC7026407
    • Cheng, C. W., Wu, C. Y., Hsu, W. L., Wong, C. H. Programmable One-Pot Synthesis of Oligosaccharides Biochemistry  2020 59:3078-3088  DOI:10.1021/acs.biochem.9b00613  PMID:31454239
    • Pawar, S., Hsu, L., Reddy, T. N., Ravinder, M., Ren, C. T., Lin, Y. W., Cheng, Y. Y., Lin, T. W., Hsu, T. L., Wang, S. K., Wong, C. H., Wu, C. Y. Synthesis of Asymmetric N-Glycans as Common Core Substrates for Structural Diversification through Selective Enzymatic Glycosylation ACS Chemical Biology  2020 15:2382-2394  DOI:10.1021/acschembio.00359  PMID:32830946
    • Cheng, C. W., Zhou, Y., Pan, W. H., Dey, S., Wu, C. Y., Hsu, W. L., Wong, C. H. Hierarchical and programmable one-pot oligosaccharide synthesis Journal of Visualized Experiments : JoVE  2019  DOI:10.3791/59987  PMID:31545316
    • Dey, S., Lo, H. J., Wong, C. H. An efficient modular one-pot synthesis of heparin-based anticoagulant idraparinux Journal of the American Chemical Society  2019 141:10309-10314  DOI:10.1021/jacs.9b03266  PMID:31244187
    • Lo, H. J., Krasnova, L., Dey, S., Cheng, T., Liu, H., Tsai, T. I., Wu, K. B., Wu, C. Y., Wong, C. H. Synthesis of sialidase-resistant oligosaccharide and antibody glycoform containing α2,6-linked 3Fax-Neu5Ac Journal of the American Chemical Society  2019 141:6484-6488  DOI:10.1021/jacs.9b01991  PMID:30969765
    • Krasnova, L., Wong, C. H. Oligosaccharide synthesis and translational innovation Journal of the American Chemical Society  2019 141:3735-3754  DOI:10.1021/jacs.8b11005  PMID:30716271
    • Wong, C. H., Krasnova, L. Highlights in chemical glycobiology Israel Journal of Chemistry  2019 59:18-22  DOI:10.1002/ijch.201800139
    • Cheng, C. W., Zhou, Y., Pan, W. H., Dey, S., Wu, C. Y., Hsu, W. L., Wong, C. H. Hierarchical and programmable one-pot synthesis of oligosaccharides Nature Communications  2018 9  DOI:10.1038/s41467-018-07618-8  PMID:30523255  PMCID:PMC6283847
    • Wang, X., Krasnova, L., Wu, K. B., Wu, W. S., Cheng, T. J., Wong, C. H. Towards new antibiotics targeting bacterial transglycosylase: Synthesis of a Lipid II analog as stable transition-state mimic inhibitor Bioorganic & Medicinal Chemistry Letters  2018 28:2708-2712  DOI:10.1016/j.bmcl.2018.03.035  PMID:29602680
    • Dey, S., Wong, C. H. Programmable one-pot synthesis of heparin pentasaccharides enabling access to regiodefined sulfate derivatives Chemical Science  2018 9:6685-6691  DOI:10.1039/c8sc01743c
    • Shivatare, S. S., Huang, L. Y., Zeng, Y. F., Liao, J. Y., You, T. H., Wang, S. Y., Cheng, T., Chiu, C. W., Chao, P., Chen, L. T., Tsai, T. I., Huang, C. C., et al. Development of glycosynthases with broad glycan specificity for the efficient glyco-remodeling of antibodies Chemical Communications  2018 54:6161-6164  DOI:10.1039/c8cc03384f  PMID:29809215
    • Shivatare, V. S., Shivatare, S. S., Lee, C. C. D., Liang, C. H., Liao, K. S., Cheng, Y. Y., Saidachary, G., Wu, C. Y., Lin, N. H., Kwong, P. D., Burton, D. R., Wu, C. Y., et al. Unprecedented role of hybrid N-glycans as ligands for HIV-1 broadly neutralizing antibodies Journal of the American Chemical Society  2018 140:5202-5210  DOI:10.1021/jacs.8b00896  PMID:29578688
    • Zhou, T., Zheng, A., Baxa, U., Chuang, G. Y., Georgiev, I. S., Kong, R., O'Dell, S., Shahzad-Ul-Hussan, S., Shen, C. H., Tsybovsky, Y., Bailer, R. T., Gift, S. K., et al. A neutralizing antibody recognizing primarily N-linked glycan targets the silent face of the HIV envelope Immunity  2018 48:500-513  DOI:10.1016/j.immuni.2018.02.013  PMID:29548671
    • Liu, C. P., Tsai, T. I., Cheng, T., Shivatare, V. S., Wu, C. Y., Wu, C. Y., Wong, C. H. Glycoengineering of antibody (Herceptin) through yeast expression and in vitro enzymatic glycosylation Proceedings of the National Academy of Sciences of the United States of America  2018 115:720-725  DOI:10.1073/pnas.1718172115  PMID:29311294  PMCID:PMC5789950
    • Huang, Y. W., Yang, H. I., Wu, Y. T., Hsu, T. L., Lin, T. W., Kelly, J. W., Wong, C. H. Residues comprising the enhanced aromatic sequon influence protein N-glycosylation efficiency Journal of the American Chemical Society  2017 139:12947-12955  DOI:10.1021/jacs.7b03868  PMID:28820257
    • Shie, J. J., Liu, Y. C., Hsiao, J. C., Fang, J. M., Wong, C. H. A cell-permeable and triazole-forming fluorescent probe for glycoconjugate imaging in live cells Chemical Communications  2017 53:1490-1493  DOI:10.1039/c6cc08805h  PMID:28084480
    • Andrabi, R., Su, C. Y., Liang, C. H., Shivatare, S. S., Briney, B., Voss, J. E., Nawazi, S. K., Wu, C. Y., Wong, C. H., Burton, D. R. Glycans function as anchors for antibodies and help drive HIV broadly neutralizing antibody development Immunity  2017 47:524-537  DOI:10.1016/j.immuni.2017.08.006  PMID:28916265  PMCID:PMC5613947
    • Tsai, T. I., Li, S. T., Liu, C. P., Chen, K. Y., Shivatare, S. S., Lin, C. W., Liao, S. F., Lin, C. W., Hsu, T. L., Wu, Y. T., Tsai, M. H., Lai, M. Y., et al. An effective bacterial fucosidase for glycoprotein remodeling ACS Chemical Biology  2017 12:63-72  DOI:10.1021/acschembio.6b00821  PMID:28103685
    • Wu, T. N., Lin, K. H., Wu, Y. T., Huang, J. R., Hung, J. T., Wu, J. C., Chen, C. Y., Chu, K. C., Lin, N. H., Yu, A. L., Wong, C. H. Phenyl glycolipids with different glycosyl groups exhibit marked differences in murine and human iNKT cell activation ACS Chemical Biology  2016 11:3431-3441  DOI:10.1021/acschembio.6b00650  PMID:27782396
    • Krasnova, L., Wong, C. H. Exploring human glycosylation for better therapies Molecular Aspects of Medicine  2016 51:125-143  DOI:10.1016/j.mam.2016.05.003  PMID:27178988
    • Sok, D., Pauthner, M., Briney, B., Lee, J. H., Saye-Francisco, K. L., Hsueh, J., Ramos, A., Le, K. M., Jones, M., Jardine, J. G., Bastidas, R., Sarkar, A., et al. A prominent site of antibody vulnerability on HIV envelope incorporates a motif associated with CCR5 binding and its camouflaging glycans Immunity  2016 45:31-45  DOI:10.1016/j.immuni.2016.06.026  PMID:27438765  PMCID:PMC4990068
    • Hsu, C. H., Park, S., Mortenson, D. E., Foley, B. L., Wang, X., Woods, R. J., Case, D. A., Powers, E. T., Wong, C. H., Dyson, H. J., Kelly, J. W. The dependence of carbohydrate-aromatic interaction strengths on the structure of the carbohydrate Journal of the American Chemical Society  2016 138:7636-7648  DOI:10.1021/jacs.6b02879  PMID:27249581  PMCID:PMC4924591
    • Stewart-Jones, G. B. E., Soto, C., Lemmin, T., Chuang, G. Y., Druz, A., Kong, R., Thomas, P. V., Wagh, K., Zhou, T., Behrens, A. J., Bylund, T., Choi, C. W., et al. Trimeric HIV-1-Env structures define glycan shields from clades A, B, and G Cell  2016 165:813-826  DOI:10.1016/j.cell.2016.04.010  PMID:27114034
    • Shivatare, S. S., Chang, S. H., Tsai, T. I., Tseng, S. Y., Shivatare, V. S., Lin, Y. S., Cheng, Y. Y., Ren, C. T., Lee, C. C. D., Pawar, S., Tsai, C. S., Shih, H. W., et al. Modular synthesis of N-glycans and arrays for the hetero-ligand binding analysis of HIV antibodies Nature Chemistry  2016 8:338-346  DOI:10.1038/nchem.2463  PMID:27001729  PMCID:PMC4806563
    • Krasnova, L., Wong, C. H. Understanding the chemistry and biology of glycosylation with glycan synthesis Annual Review of Biochemistry  2016 85:599-630  DOI:10.1146/annurev-biochem-060614-034420  PMID:27145845
    • Li, X., Kawamura, A., Andrews, C. D., Miller, J. L., Wu, D., Tsao, T., Zhang, M., Oren, D., Padte, N. N., Porcelli, S. A., Wong, C. H., Kappe, S. H. I., et al. Colocalization of a CD1d-binding glycolipid with a radiation-attenuated sporozoite vaccine in lymph node-resident dendritic cells for a robust adjuvant effect Journal of Immunology  2015 195:2710-2721  DOI:10.4049/jimmunol.1403017  PMID:26254338  PMCID:PMC4561196
    • Danishefsky, S. J., Shue, Y. K., Chang, M. N., Wong, C. H. Development of globo-h cancer vaccine Accounts of Chemical Research  2015 48:643-652  DOI:10.1021/ar5004187  PMID:25665650
    • Hsu, C. H., Schelwies, M., Enck, S., Huang, L. Y., Huang, S. H., Chang, Y. F., Cheng, T. J. R., Cheng, W. C., Wong, C. H. Iminosugar C-glycoside analogues of alpha-D-GlcNAc-1-Phosphate: synthesis and bacterial transglycosylase inhibition Journal of Organic Chemistry  2014 79:8629-8637  DOI:10.1021/jo501340s  PMID:25137529  PMCID:PMC4168788
    • Falkowska, E., Le, K. M., Ramos, A., Doores, K. J., Lee, J. H., Blattner, C., Ramirez, A., Derking, R., van Gils, M. J., Liang, C. H., McBride, R., von Bredow, B., et al. Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the prefusion conformation of gp41 on cleaved envelope trimers Immunity  2014 40:657-668  DOI:10.1016/j.immuni.2014.04.009  PMID:24768347  PMCID:PMC4070425
    • Lin, J., Chang, Y., Yang, W. B., Yu, A. L., Wong, C. H. The multifaceted effects of polysaccharides isolated from Dendrobium huoshanense on immune functions with the induction of interleukin-1 receptor antagonist (IL-1ra) in monocytes PLoS One  2014 9:e94040  DOI:10.1371/journal.pone.0094040  PMID:24705413  PMCID:PMC3976396
    • Padte, N. N., Boente-Carrera, M., Andrews, C. D., McManus, J., Grasperge, B. F., Gettie, A., Coelho-dos-Reis, J. G., Li, X., Wu, D., Bruder, J. T., Sedegah, M., Patterson, N., et al. A glycolipid adjuvant, 7DW8-5, enhances CD8+T cell responses induced by an adenovirus-vectored malaria vaccine in non-human primates PLoS One  2013 8:e78407  DOI:10.1371/journal.pone.0078407  PMID:24205224  PMCID:PMC3808339
    • Liao, S. F., Liang, C. H., Ho, M. Y., Hsu, T. L., Tsai, T. I., Hsieh, Y. S., Tsai, C. M., Li, S. T., Cheng, Y. Y., Tsao, S. M., Lin, T. Y., Lin, Z. Y., et al. Immunization of fucose-containing polysaccharides from Reishi mushroom induces antibodies to tumor-associated Globo H-series epitopes Proceedings of the National Academy of Sciences of the United States of America  2013 110:13809-14  DOI:10.1073/pnas.1312457110  PMID:23908400  PMCID:PMC3752246
    • Chen, W., Enck, S., Price, J. L., Powers, D. L., Powers, E. T., Wong, C. H., Dyson, H. J., Kelly, J. W. Structural and energetic basis of carbohydrate-aromatic packing interactions in proteins Journal of the American Chemical Society  2013 135:9877-9884  DOI:10.1021/ja4040472  PMID:23742246  PMCID:PMC3715148
    • Huang, H. W., Chen, C. H., Lin, C. H., Wong, C. H., Lin, K. I. B-cell maturation antigen is modified by a single N-glycan chain that modulates ligand binding and surface retention Proceedings of the National Academy of Sciences of the United States of America  2013 110:10928-33  DOI:10.1073/pnas.1309417110  PMID:23776238  PMCID:PMC3704023
    • Doores, K. J., Huber, M., Le, K. M., Wang, S. K., Doyle-Cooper, C., Cooper, A., Pantophlet, R., Wong, C. H., Nemazee, D., Burton, D. R. 2G12-expressing B cell lines may aid in HIV carbohydrate vaccine design strategies Journal of Virology  2013 87:2234-2241  DOI:10.1128/jvi.02820-12  PMID:23221565  PMCID:PMC3571453
    • Al-Shareffi, E., Chaubard, J. L., Leonhard-Melief, C., Wang, S. K., Wong, C. H., Haltiwanger, R. S. 6-alkynyl fucose is a bioorthogonal analog for O-fucosylation of epidermal growth factor-like repeats and thrombospondin Type-1 repeats by protein O-fucosyltransferases 1 and 2 Glycobiology  2013 23:188-198  DOI:10.1093/glycob/cws140  PMID:23045360  PMCID:PMC3531295
    • Cheng, T. J. R., Weinheimer, S., Tarbet, E. B., Jan, J. T., Cheng, Y. S. E., Shie, J. J., Chen, C. L., Chen, C. A., Hsieh, W. C., Huang, P. W., Lin, W. H., Wang, S. Y., et al. Development of oseltamivir phosphonate congeners as anti-influenza agents Journal of Medicinal Chemistry  2012 55:8657-8670  DOI:10.1021/jm3008486  PMID:23009169  PMCID:PMC3492761
    • Liu, K. C., Fang, J. M., Jan, J. T., Cheng, T. J. R., Wang, S. Y., Yang, S. T., Cheng, Y. S. E., Wong, C. H. Enhanced anti-influenza agents conjugated with anti-inflammatory activity Journal of Medicinal Chemistry  2012 55:8493-8501  DOI:10.1021/jm3009844  PMID:22963087
    • Hsieh, M. H., Hung, J. T., Liw, Y. W., Lu, Y. J., Wong, C. H., Yu, A. L., Liang, P. H. Synthesis and evaluation of acyl-chain- and galactose-6 ''-modified analogues of alpha-galcer for nkt cell activation ChemBioChem  2012 13:1689-1697  DOI:10.1002/cbic.201200004  PMID:22730199
    • Zulueta, M. M. L., Lin, S. Y., Lin, Y. T., Huang, C. J., Wang, C. C., Ku, C. C., Shi, Z. H., Chyan, C. L., Irene, D., Lim, L. H., Tsai, T. I., Hu, Y. P., et al. Alpha-glycosylation by d-glucosamine-derived donors: Synthesis of heparosan and heparin analogues that interact with mycobacterial heparin-binding hemagglutinin Journal of the American Chemical Society  2012 134:8988-8995  DOI:10.1021/ja302640p  PMID:22587381
    • Huang, C. Y., Shih, H. W., Lin, L. Y., Tien, Y. W., Cheng, T. J. R., Cheng, W. C., Wong, C. H., Ma, C. Crystal structure of staphylococcus aureus transglycosylase in complex with a lipid ii analog and elucidation of peptidoglycan synthesis mechanism Proceedings of the National Academy of Sciences of the United States of America  2012 109:6496-6501  DOI:10.1073/pnas.1203900109  PMID:22493270  PMCID:PMC3340074
    • Hsu, Y., Lu, X. A., Zulueta, M. M. L., Tsai, C. M., Lin, K. I., Hung, S. C., Wong, C. H. Acyl and silyl group effects in reactivity-based one-pot glycosylation: Synthesis of embryonic stem cell surface carbohydrates lc(4) and iv(2)fuc-lc(4) Journal of the American Chemical Society  2012 134:4549-4552  DOI:10.1021/ja300284x  PMID:22390569
    • Chen, S. H., Hwang, D. R., Chen, G. H., Hsu, N. S., Wu, Y. T., Li, T. L., Wong, C. H. Engineering transaldolase in Pichia stipitis to improve bioethanol production ACS Chemical Biology  2012 7:481-486  DOI:10.1021/cb200396b  PMID:22148723
    • Lenger, J., Schroder, M., Ennemann, E. C., Muller, B., Wong, C. H., Noll, T., Dierks, T., Hanson, S. R., Sewald, N. Evaluation of sulfatase-directed quinone methide traps for proteomics Bioorganic & Medicinal Chemistry  2012 20:622-627  DOI:10.1016/j.bmc.2011.04.044  PMID:21570853  PMCID:PMC3396293
    • Shih, H. W., Chang, Y. F., Li, W. J., Meng, F. C., Huang, C. Y., Ma, C., Cheng, T. J. R., Wong, C. H., Cheng, W. C. Effect of the peptide moiety of lipid ii on bacterial transglycosylase Angewandte Chemie-International Edition  2012 51:10123-10126  DOI:10.1002/anie.201204038  PMID:22952114
    • Price, J. L., Culyba, E. K., Chen, W., Murray, A. N., Hanson, S. R., Wong, C. H., Powers, E. T., Kelly, J. W. N-glycosylation of enhanced aromatic sequons to increase glycoprotein stability Biopolymers  2012 98:195-211  DOI:10.1002/bip.22030  PMID:22782562  PMCID:PMC3539202
    • Punyadarsaniya, D., Liang, C. H., Winter, C., Petersen, H., Rautenschlein, S., Hennig-Pauka, I., Schwegmann-Wessels, C., Wu, C. Y., Wong, C. H., Herrler, G. Infection of differentiated porcine airway epithelial cells by influenza virus: Differential susceptibility to infection by porcine and avian viruses PLoS One  2011 6:e28429  DOI:10.1371/journal.pone.0028429  PMID:22174804  PMCID:PMC3235120
    • Pejchal, R., Doores, K. J., Walker, L. M., Khayat, R., Huang, P. S., Wang, S. K., Stanfield, R. L., Julien, J. P., Ramos, A., Crispin, M., Depetris, R., Katpally, U., et al. A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield Science  2011 334:1097-1103  DOI:10.1126/science.1213256  PMID:21998254  PMCID:PMC3280215
    • Shie, J. J., Fang, J. M., Lai, P. T., Wen, W. H., Wang, S. Y., Cheng, Y. S. E., Tsai, K. C., Yang, A. S., Wong, C. H. A practical synthesis of zanamivir phosphonate congeners with potent anti-influenza activity Journal of the American Chemical Society  2011 133:17959-17965  DOI:10.1021/ja207892q  PMID:21942552
    • Wu, T. N., Lin, K. H., Chang, Y. J., Huang, J. R., Cheng, J. Y., Yu, A. L., Wong, C. H. Avidity of cd1d-ligand-receptor ternary complex contributes to t-helper 1 (th1) polarization and anticancer efficacy Proceedings of the National Academy of Sciences of the United States of America  2011 108:17275-17280  DOI:10.1073/pnas.1114255108  PMID:21987790  PMCID:PMC3198369
    • Meng, F. C., Chen, K. T., Huang, L. Y., Shih, H. W., Chang, H. H., Nien, F. Y., Liang, P. H., Cheng, T. J. R., Wong, C. H., Cheng, W. C. Total synthesis of polyprenyl n-glycolyl lipid ii as a mycobacterial transglycosylase substrate Organic Letters  2011 13:5306-5309  DOI:10.1021/ol2021687  PMID:21913698
    • Shen, Y. F., Chen, Y. H., Chu, S. Y., Lin, M. I., Hsu, H. T., Wu, P. Y., Wu, C. J., Liu, H. W., Lin, F. Y., Lin, G., Hsu, P. H., Yang, A. S., et al. E339 ... R416 salt bridge of nucleoprotein as a feasible target for influenza virus inhibitors Proceedings of the National Academy of Sciences of the United States of America  2011 108:16515-16520  DOI:10.1073/pnas.1113107108  PMID:21930946  PMCID:PMC3189076
    • Kinjo, Y., Illarionov, P., Vela, J. L., Pei, B., Girardi, E., Li, X. M., Li, Y. L., Imamura, M., Kaneko, Y., Okawara, A., Miyazaki, Y., Gomez-Velasco, A., et al. Invariant natural killer t cells recognize glycolipids from pathogenic gram-positive bacteria Nature Immunology  2011 12:966-974  DOI:10.1038/ni.2096  PMID:21892173  PMCID:PMC3178673
    • Walker, L. M., Huber, M., Doores, K. J., Falkowska, E., Pejchal, R., Julien, J. P., Wang, S. K., Ramos, A., Chan-Hui, P. Y., Moyle, M., Mitcham, J. L., Hammond, P. W., et al. Broad neutralization coverage of HIV by multiple highly potent antibodies Nature  2011 477:466-470  DOI:10.1038/nature10373  PMID:21849977  PMCID:PMC3393110
    • Shih, H. W., Chen, K. T., Cheng, T. J. R., Wong, C. H., Cheng, W. C. A new synthetic approach toward bacterial transglycosylase substrates, lipid ii and lipid iv Organic Letters  2011 13:4600-4603  DOI:10.1021/ol201806d  PMID:21797279
    • Chen, J. R., Ma, C., Wong, C. H. Vaccine design of hemagglutinin glycoprotein against influenza Trends in Biotechnology  2011 29:426-434  DOI:10.1016/j.tibtech.2011.04.007  PMID:21640418
    • Yen, H. L., Liang, C. H., Wu, C. Y., Forrest, H. L., Ferguson, A., Choy, K. T., Jones, J., Wong, D. D. Y., Cheung, P. P. H., Hsu, C. H., Li, O. T., Yuen, K. M., et al. Hemagglutinin-neuraminidase balance confers respiratory-droplet transmissibility of the pandemic h1n1 influenza virus in ferrets Proceedings of the National Academy of Sciences of the United States of America  2011 108:14264-14269  DOI:10.1073/pnas.1111000108  PMID:21825167  PMCID:PMC3161546
    • Liu, K. C., Lee, P. S., Wang, S. Y., Cheng, Y. S. E., Fang, J. M., Wong, C. H. Intramolecular ion-pair prodrugs of zanamivir and guanidino-oseltamivir Bioorganic & Medicinal Chemistry  2011 19:4796-4802  DOI:10.1016/j.bmc.2011.06.080  PMID:21778065
    • Liu, Y. C., Yen, H. Y., Chen, C. Y., Chen, C. H., Cheng, P. F., Juan, Y. H., Khoo, K. H., Yu, C. J., Yang, P. C., Hsu, T. L., Wong, C. H. Sialylation and fucosylation of epidermal growth factor receptor suppress its dimerization and activation in lung cancer cells Proceedings of the National Academy of Sciences of the United States of America  2011 108:11332-11337  DOI:10.1073/pnas.1107385108  PMID:21709263  PMCID:PMC3136320
    • Schmaltz, R. M., Hanson, S. R., Wong, C. H. Enzymes in the synthesis of glycoconjugates Chemical Reviews  2011 111:4259-4307  DOI:10.1021/cr200113w  PMID:21749134
    • Chang, C. F., Pan, J. F., Wu, I. L., Wong, C. H., Lin, C. H. Rapid characterization of sugar-binding specificity by in-solution proximity binding with photosensitizers Glycobiology  2011 21:895-902  DOI:10.1093/glycob/cwr021  PMID:21325337
    • Tsai, B. L., Han, J. L., Ren, C. T., Wu, C. Y., Wong, C. H. Programmable one-pot synthesis of tumor-associated carbohydrate antigens lewis x dimer and kh-1 epitopes Tetrahedron Letters  2011 52:2132-2135  DOI:10.1016/j.tetlet.2010.11.055
    • Chou, C. Y., Ko, T. P., Wu, K. J., Huang, K. F., Wong, C. H., Wang, A. H. J., Lin, C. H. Modulation of substrate specificities of D-sialic acid aldolase through single mutations of Val-251 Journal of Biological Chemistry  2011 286:14057-14064  DOI:10.1074/jbc.M110.179465  PMID:21270125  PMCID:PMC3077606
    • Lee, R. T., Hsu, T. L., Huang, S. K., Hsieh, S. L., Wong, C. H., Lee, Y. C. Survey of immune-related, mannose/fucose-binding c-type lectin receptors reveals widely divergent sugar-binding specificities Glycobiology  2011 21:512-520  DOI:10.1093/glycob/cwq193  PMID:21112966  PMCID:PMC3055596
    • Chen, M. W., Liao, H. Y., Huang, Y. X., Jan, J. T., Huang, C. C., Ren, C. T., Wu, C. Y., Cheng, T. J. R., Ho, D. D., Wong, C. H. Broadly neutralizing DNA vaccine with specific mutation alters the antigenicity and sugar-binding activities of influenza hemagglutinin Proceedings of the National Academy of Sciences of the United States of America  2011 108:3510-3515  DOI:10.1073/pnas.1019744108  PMID:21321237  PMCID:PMC3048126
    • Culyba, E. K., Price, J. L., Hanson, S. R., Dhar, A., Wong, C. H., Gruebele, M., Powers, E. T., Kelly, J. W. Protein native-state stabilization by placing aromatic side chains in N-glycosylated reverse turns Science  2011 331:571-575  DOI:10.1126/science.1198461  PMID:21292975  PMCID:PMC3099596
    • Wu, C. Y., Wong, C. H. Chemistry and glycobiology Chemical Communications  2011 47:6201-6207  DOI:10.1039/c0cc04359a  PMID:21503322
    • Liang, C. H., Wang, S. K., Lin, C. W., Wang, C. C., Wong, C. H., Wu, C. Y. Effects of neighboring glycans on antibody-carbohydrate interaction Angewandte Chemie-International Edition  2011 50:1608-1612  DOI:10.1002/anie.201003482  PMID:21308915
    • Chu, K. C., Ren, C. T., Lu, C. P., Hsu, C. H., Sun, T. H., Han, J. L., Pal, B., Chao, T. A., Lin, Y. F., Wu, S. H., Wong, C. H., Wu, C. Y. Efficient and stereoselective synthesis of alpha(2 -> 9) oligosialic acids: From monomers to dodecamers Angewandte Chemie-International Edition  2011 50:9391-9395  DOI:10.1002/anie.201101794  PMID:21948436
    • Hsu, J. W., Huang, H. C., Chen, S. T., Wong, C. H., Juan, H. F. Ganoderma lucidum polysaccharides induce macrophage-like differentiation in human leukemia thp-1 cells via caspase and p53 activation Evidence-Based Complementary and Alternative Medicine  2011 1-13  DOI:10.1093/ecam/nep107  PMID:19696196  PMCID:PMC3135330
    • Hsu, C. H., Hung, S. C., Wu, C. Y., Wong, C. H. Toward automated oligosaccharide synthesis Angewandte Chemie-International Edition  2011 50:11872-11923  DOI:10.1002/anie.201100125  PMID:22127846
    • Chen, W. Y., Yang, W. B., Wong, C. H., Shih, D. T. B. Effect of reishi polysaccharides on human stem/progenitor cells Bioorganic & Medicinal Chemistry  2010 18:8583-8591  DOI:10.1016/j.bmc.2010.10.016  PMID:21055951
    • Cheng, T. J. R., Wu, Y. T., Yang, S. T., Lo, K. H., Chen, S. K., Chen, Y. H., Huang, W. I., Yuan, C. H., Guo, C. W., Huang, L. Y., Chen, K. T., Shih, H. W., et al. High-throughput identification of antibacterials against methicillin-resistant staphylococcus aureus (mrsa) and the transglycosylase Bioorganic & Medicinal Chemistry  2010 18:8512-8529  DOI:10.1016/j.bmc.2010.10.036  PMID:21075637
    • Lewis, J. C., Mantovani, S. M., Fu, Y., Snow, C. D., Komor, R. S., Wong, C. H., Arnold, F. H. Combinatorial alanine substitution enables rapid optimization of cytochrome p450(bm3) for selective hydroxylation of large substrates ChemBioChem  2010 11:2502-2505  DOI:10.1002/cbic.201000565  PMID:21108271  PMCID:PMC4447097
    • Schelwies, M., Brinson, D., Otsuki, S., Hong, Y. H., Lotz, M. K., Wong, C. H., Hanson, S. R. Glucosamine-6-sulfamate analogues of heparan sulfate as inhibitors of endosulfatases ChemBioChem  2010 11:2393-2397  DOI:10.1002/cbic.201000401  PMID:20973023  PMCID:PMC3086843
    • Su, C. Y., Cheng, T. J. R., Lin, M. I., Wang, S. Y., Huang, W. I., Lin-Chu, S. Y., Chen, Y. H., Wu, C. Y., Lai, M. M. C., Cheng, W. C., Wu, Y. T., Tsai, M. D., et al. High-throughput identification of compounds targeting influenza rna-dependent rna polymerase activity Proceedings of the National Academy of Sciences of the United States of America  2010 107:19151-19156  DOI:10.1073/pnas.1013592107  PMID:20974907  PMCID:PMC2984200
    • Liao, H. Y., Hsu, C. H., Wang, S. C., Liang, C. H., Yen, H. Y., Su, C. Y., Chen, C. H., Jan, J. T., Ren, C. T., Cheng, T. J. R., Wu, C. Y., Wong, C. H. Differential receptor binding affinities of influenza hemagglutinins on glycan arrays Journal of the American Chemical Society  2010 132:14849-14856  DOI:10.1021/ja104657b  PMID:20882975
    • Shie, J. J., Chen, C. A., Lin, C. C., Ku, A. F., Cheng, T. J. R., Fang, J. M., Wong, C. H. Regioselective synthesis of di-c-glycosylflavones possessing anti-inflammation activities Organic & Biomolecular Chemistry  2010 8:4451-4462  DOI:10.1039/c0ob00011f  PMID:20725659
    • Lin, K. H., Liang, J. J., Huang, W. I., Lin-Chu, S. Y., Su, C. Y., Lee, Y. L., Jan, J. T., Lin, Y. L., Cheng, Y. S. E., Wong, C. H. In vivo protection provided by a synthetic new alpha-galactosyl ceramide analog against bacterial and viral infections in murine models Antimicrobial Agents and Chemotherapy  2010 54:4129-4136  DOI:10.1128/aac.00368-10  PMID:20660669  PMCID:PMC2944612
    • Chang, S. H., Han, J. L., Tseng, S. Y., Lee, H. Y., Lin, C. W., Lin, Y. C., Jeng, W. Y., Wang, A. H. J., Wu, C. Y., Wong, C. H. Glycan array on aluminum oxide-coated glass slides through phosphonate chemistry Journal of the American Chemical Society  2010 132:13371-13380  DOI:10.1021/ja1046523  PMID:20822102
    • Li, X. M., Fujio, M., Imamura, M., Wu, D., Vasan, S., Wong, C. H., Ho, D. D., Tsuji, M. Design of a potent CD1d-binding NKT cell ligand as a vaccine adjuvant Proceedings of the National Academy of Sciences of the United States of America  2010 107:13010-13015  DOI:10.1073/pnas.1006662107  PMID:20616071  PMCID:PMC2919905
    • Wen, W. H., Wang, S. Y., Tsai, K. C., Cheng, Y. S. E., Yang, A. S., Fang, J. M., Wong, C. H. Analogs of zanamivir with modified c4-substituents as the inhibitors against the group-1 neuraminidases of influenza viruses Bioorganic & Medicinal Chemistry  2010 18:4074-4084  DOI:10.1016/j.bmc.2010.04.010  PMID:20452227
    • Otsuki, S., Hanson, S. R., Miyaki, S., Grogan, S. P., Kinoshita, M., Asahara, H., Wong, C. H., Lotz, M. K. Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways Proceedings of the National Academy of Sciences of the United States of America  2010 107:10202-10207  DOI:10.1073/pnas.0913897107  PMID:20479257  PMCID:PMC2890424
    • Astronomo, R. D., Kaltgrad, E., Udit, A. K., Wang, S. K., Doores, K. J., Huang, C. Y., Pantophlet, R., Paulson, J. C., Wong, C. H., Finn, M. G., Burton, D. R. Defining criteria for oligomannose immunogens for HIV using icosahedral virus capsid scaffolds Chemistry & Biology  2010 17:357-370  DOI:10.1016/j.chembiol.2010.03.012  PMID:20416507  PMCID:PMC2867452
    • Liu, C. Y., Guo, C. W., Chang, Y. F., Wang, J. T., Shih, H. W., Hsu, Y. F., Chen, C. W., Chen, S. K., Wang, Y. C., Cheng, T. J. R., Ma, C., Wong, C. H., et al. Synthesis and evaluation of a new fluorescent transglycosylase substrate: Lipid ii-based molecule possessing a dansyl-c20 polyprenyl moiety Organic Letters  2010 12:1608-1611  DOI:10.1021/ol100338v  PMID:20187630
    • Chang, C. C., Ku, A. F., Tseng, Y. Y., Yang, W. B., Fang, J. M., Wong, C. H. 6,8-di-C-glycosyl flavonoids from Dendrobium huoshanense Journal of Natural Products  2010 73:229-232  DOI:10.1021/np900252f  PMID:20055483
    • Payne, R. J., Wong, C. H. Advances in chemical ligation strategies for the synthesis of glycopeptides and glycoproteins Chemical Communications  2010 46:21-43  DOI:10.1039/b913845e  PMID:20024291
    • Shih, H. W., Chen, K. T., Chen, S. K., Huang, C. Y., Cheng, T. J. R., Ma, C., Wong, C. H., Cheng, W. C. Combinatorial approach toward synthesis of small molecule libraries as bacterial transglycosylase inhibitors Organic & Biomolecular Chemistry  2010 8:2586-2593  DOI:10.1039/c000622j  PMID:20485795
    • Tsai, C. S., Liu, P. Y., Yen, H. Y., Hsu, T. L., Wong, C. H. Development of trifunctional probes for glycoproteomic analysis Chemical Communications  2010 46:5575-5577  DOI:10.1039/c0cc00345j  PMID:20467665
    • Hsu, C. H., Chu, K. C., Lin, Y. S., Han, J. L., Peng, Y. S., Ren, C. T., Wu, C. Y., Wong, C. H. Highly alpha-selective sialyl phosphate donors for efficient preparation of natural sialosides Chemistry-a European Journal  2010 16:1754-1760  DOI:10.1002/chem.200903035  PMID:20066711
    • Hsu, T. L., Cheng, S. C., Yang, W. B., Chin, S. W., Chen, B. H., Huang, M. T., Hsieh, S. L., Wong, C. H. Profiling carbohydrate-receptor interaction with recombinant innate immunity receptor-fc fusion proteins Journal of Biological Chemistry  2009 284:34479-34489  DOI:10.1074/jbc.M109.065961  PMID:19837675  PMCID:PMC2787309
    • Schiefner, A., Fujio, M., Wu, D., Wong, C. H., Wilson, I. A. Structural evaluation of potent NKT cell agonists: Implications for design of novel stimulatory ligands Journal of Molecular Biology  2009 394:71-82  DOI:10.1016/j.jmb.2009.08.061  PMID:19732779  PMCID:PMC2792987
    • Chuang, M. H., Chiou, S. H., Huang, C. H., Yang, W. B., Wong, C. H. The lifespan-promoting effect of acetic acid and reishi polysaccharide Bioorganic & Medicinal Chemistry  2009 17:7831-7840  DOI:10.1016/j.bmc.2009.09.002  PMID:19837596
    • Wang, C. C., Chen, J. R., Tseng, Y. C., Hsu, C. H., Hung, Y. F., Chen, S. W., Chen, C. M., Khoo, K. H., Cheng, T. J., Cheng, Y. S. E., Jan, J. T., Wu, C. Y., et al. Glycans on influenza hemagglutinin affect receptor binding and immune response Proceedings of the National Academy of Sciences of the United States of America  2009 106:18137-18142  DOI:10.1073/pnas.0909696106  PMID:19822741  PMCID:PMC2775302
    • Lewis, J. C., Bastian, S., Bennett, C. S., Fu, Y., Mitsuda, Y., Chen, M. M., Greenberg, W. A., Wong, C. H., Arnold, F. H. Chemoenzymatic elaboration of monosaccharides using engineered cytochrome p450(bm3) demethylases Proceedings of the National Academy of Sciences of the United States of America  2009 106:16550-16555  DOI:10.1073/pnas.0908954106  PMID:19805336  PMCID:PMC2757845
    • Liang, C. H., Wang, C. C., Lin, Y. C., Chen, C. H., Wong, C. H., Wu, C. Y. Iron oxide/gold core/shell nanoparticles for ultrasensitive detection of carbohydrate-protein interactions Analytical Chemistry  2009 81:7750-7756  DOI:10.1021/ac9012286  PMID:19689135
    • Wen, W. H., Lin, M. G., Su, C. Y., Wang, S. Y., Cheng, Y. S. E., Fang, J. M., Wong, C. H. Synergistic effect of zanamivir-porphyrin conjugates on inhibition of neuraminidase and inactivation of influenza virus Journal of Medicinal Chemistry  2009 52:4903-4910  DOI:10.1021/jm900515g  PMID:19522501
    • Hong, Z. Y., Liu, L., Sugiyama, M., Fu, Y., Wong, C. H. Concise synthesis of iminocyclitols via petasis-type aminocyclization Journal of the American Chemical Society  2009 131:8352-8353  DOI:10.1021/ja901656e  PMID:19530721  PMCID:PMC2900252
    • Sung, M. T., Lai, Y. T., Huang, C. Y., Chou, L. Y., Shih, H. W., Cheng, W. C., Wong, C. H., Ma, C. Crystal structure of the membrane-bound bifunctional transglycosylase pbp1b from escherichia coli Proceedings of the National Academy of Sciences of the United States of America  2009 106:8824-8829  DOI:10.1073/pnas.0904030106  PMID:19458048  PMCID:PMC2689995
    • Hanson, S. R., Culyba, E. K., Hsu, T. L., Wong, C. H., Kelly, J. W., Powers, E. T. The core trisaccharide of an N-linked glycoprotein intrinsically accelerates folding and enhances stability Proceedings of the National Academy of Sciences of the United States of America  2009 106:3131-3136  DOI:10.1073/pnas.0810318105  PMID:19204290  PMCID:PMC2651298
    • Wang, S. Y., Su, C. Y., Lin, M. G., Huang, S. Y., Huang, W. I., Wang, C. C., Wu, Y. T., Cheng, T. J. R., Yu, H. M., Ren, C. T., Wu, C. Y., Wong, C. H., et al. Ha-pseudotyped retroviral vectors for influenza antagonist screening Journal of Biomolecular Screening  2009 14:294-302  DOI:10.1177/1087057108330786  PMID:19211776
    • Motiei, L., Rahimipour, S., Thayer, D. A., Wong, C. H., Ghadiri, M. R. Antibacterial cyclic D,L-alpha-glycopeptides Chemical Communications  2009 3693-3695  DOI:10.1039/b902455g  PMID:19557251  PMCID:PMC2758689
    • Wong, C. H. Enzymes for glycoprotein synthesis Chimia  2009 63:318-326  DOI:10.2533/chimia.2009.318
    • Wu, C. Y., Liang, P. H., Wong, C. H. New development of glycan arrays Organic & Biomolecular Chemistry  2009 7:2247-2254  DOI:10.1039/b902510n  PMID:19462030
    • Tupin, E., Benhnia, M. R., Kinjo, Y., Patsey, R., Lena, C. J., Haller, M. C., Caimano, M. J., Imamura, M., Wong, C. H., Crotty, S., Radolf, J. D., Sellati, T. J., et al. Nkt cells prevent chronic joint inflammation after infection with borrelia burgdorferi Proceedings of the National Academy of Sciences of the United States of America  2008 105:19863-19868  DOI:10.1073/pnas.0810519105  PMID:19060201  PMCID:PMC2604993
    • Shi, C. S., Shi, G. Y., Hsiao, S. M., Kao, Y. C., Kuo, K. L., Ma, C. Y., Kuo, C. H., Chang, B. I., Chang, C. F., Wong, C. H., Wu, H. L., Lin, C. H. Lectin-like domain of thrombomodulin binds to its specific ligand Lewis Y antigen and neutralizes lipopolysaccharide-induced inflammatory response Blood  2008 112:3661-3670  DOI:10.1182/blood-2008-03-142760  PMID:18711002  PMCID:PMC2572793
    • Giffin, M. J., Heaslet, H., Brik, A., Lin, Y. C., Cauvi, G., Wong, C. H., McRee, D. E., Elder, J. H., Stout, C. D., Torbett, B. E. A copper(I)-catalyzed 1,2,3-triazole azide-alkyne click compound is a potent inhibitor of a multidrug-resistant HIV-1 protease variant Journal of Medicinal Chemistry  2008 51:6263-6270  DOI:10.1021/jm800149m  PMID:18823110  PMCID:PMC2744648
    • Liang, P. H., Imamura, M., Li, X. M., Wu, D., Fujio, M., Guy, R. T., Wu, B. C., Tsuji, M., Wong, C. H. Quantitative microarray analysis of intact glycolipid-CD1d interaction and correlation with cell-based cytokine production Journal of the American Chemical Society  2008 130:12348-12354  DOI:10.1021/ja8012787  PMID:18712867  PMCID:PMC4455950
    • Bennett, C. S., Dean, S. M., Payne, R. J., Ficht, S., Brik, A., Wong, C. H. Sugar-assisted glycopeptide ligation with complex oligosaccharides: Scope and limitations Journal of the American Chemical Society  2008 130:11945-11952  DOI:10.1021/ja8010513  PMID:18698778  PMCID:PMC2577756
    • Chen, M. W., Cheng, T. J. R., Huang, Y. X., Jan, J. T., Ma, S. H., Yu, A. L., Wong, C. H., Ho, D. D. A consensus-hemagglutinin-based DNA vaccine that protects mice against divergent H5N1 influenza viruses Proceedings of the National Academy of Sciences of the United States of America  2008 105:13538-13543  DOI:10.1073/pnas.0806901105  PMID:18765801  PMCID:PMC2533225
    • Su, C. Y., Wang, S. Y., Shie, J. J., Jeng, K. S., Temperton, N. J., Fang, J. M., Wong, C. H., Cheng, Y. S. E. In vitro evaluation of neuraminidase inhibitors using the neuraminidase-dependent release assay of hemagglutinin-pseudotyped viruses Antiviral Research  2008 79:199-205  DOI:10.1016/j.antiviral.2008.03.002  PMID:18453004
    • Wang, C. C., Huang, Y. L., Ren, C. T., Lin, C. W., Hung, J. T., Yu, J. C., Yu, A. L., Wu, C. Y., Wong, C. H. Glycan microarray of globo h and related structures for quantitative analysis of breast cancer Proceedings of the National Academy of Sciences of the United States of America  2008 105:11661-11666  DOI:10.1073/pnas.0804923105  PMID:18689688  PMCID:PMC2575271
    • Kinjo, Y., Pei, B., Bufali, S., Raju, R., Richardson, S. K., Imamura, M., Fujio, M., Wu, D., Khurana, A., Kawahara, K., Wong, C. H., Howell, A. R., et al. Natural sphingomonas glycolipids vary greatly in their ability to activate natural killer T cells Chemistry & Biology  2008 15:654-664  DOI:10.1016/j.chembiol.2008.05.012  PMID:18635002  PMCID:PMC2519143
    • Astronomo, R. D., Lee, H. K., Scanlan, C. N., Pantophlet, R., Huang, C. Y., Wilson, I. A., Blixt, O., Dwek, R. A., Wong, C. H., Burton, D. R. A glycoconjugate antigen based on the recognition motif of a broadly neutralizing human immunodeficiency virus antibody, 2g12, is immunogenic but elicits antibodies unable to bind to the self glycans of gp120 Journal of Virology  2008 82:6359-6368  DOI:10.1128/jvi.00293-08  PMID:18434393  PMCID:PMC2447108
    • Hsu, N. F., Tseng, S. Y., Wu, C. Y., Ren, C. T., Lee, Y. C., Wong, C. H., Chen, C. H. Desorption ionization of biomolecules on metals Analytical Chemistry  2008 80:5203-5210  DOI:10.1021/ac800435r  PMID:18489127
    • Sugiyama, M., Greenberg, W., Wong, C. H. Recent advances in aldolase-catalyzed synthesis of unnatural sugars and iminocyclitols Journal of Synthetic Organic Chemistry Japan  2008 66:605-615
    • Hsieh, Y. S. Y., Chien, C., Liao, S. K. S., Liao, S. F., Hung, W. T., Yang, W. B., Lin, C. C., Cheng, T. J. R., Chang, C. C., Fang, J. M., Wong, C. H. Structure and bioactivity of the polysaccharides in medicinal plant dendrobium huoshanense Bioorganic & Medicinal Chemistry  2008 16:6054-6068  DOI:10.1016/j.bmc.2008.04.042  PMID:18467102
    • Chen, S. T., Lin, Y. L., Huang, M. T., Wu, M. F., Cheng, S. C., Lei, H. Y., Lee, C. K., Chiou, T. W., Wong, C. H., Hsieh, S. L. Clec5a is critical for dengue-virus-induced lethal disease Nature  2008 453:672-676  DOI:10.1038/nature07013  PMID:18496526
    • Shao, Y. M., Yang, W. B., Kuo, T. H., Tsai, K. C., Yang, A. S., Liang, P. H., Wong, C. H., Lin, C. H. Design, synthesis, and evaluation of trifluoromethyl ketones as inhibitors of SARS-CoV 3CL protease Bioorganic & Medicinal Chemistry  2008 16:4652-4660  DOI:10.1016/j.bmc.2008.02.040  PMID:18329272
    • Northen, T. R., Lee, J. C., Hoang, L., Raymond, J., Hwang, D. R., Yannone, S. M., Wong, C. H., Siuzdak, G. A nanostructure-initiator mass spectrometry-based enzyme activity assay Proceedings of the National Academy of Sciences of the United States of America  2008 105:3678-3683  DOI:10.1073/pnas.0712332105  PMID:18319341  PMCID:PMC2268803
    • Wang, S. K., Liang, P. H., Astronomo, R. D., Hsu, T. L., Hsieh, S. L., Burton, D. R., Wong, C. H. Targeting the carbohydrates on HIV-1: Interaction of oligomannose dendrons with human monoclonal antibody 2G12 and DC-SIGN Proceedings of the National Academy of Sciences of the United States of America  2008 105:3690-3695  DOI:10.1073/pnas.0712326105  PMID:18310320  PMCID:PMC2268808
    • Liang, P. H., Wu, C. Y., Greenberg, W. A., Wong, C. H. Glycan arrays: Biological and medical applications Current Opinion in Chemical Biology  2008 12:86-92  DOI:10.1016/j.cbpa.2008.01.031  PMID:18258211
    • Wu, D., Fujio, M., Wong, C. H. Glycolipids as immunostimulating agents Bioorganic & Medicinal Chemistry  2008 16:1073-1083  DOI:10.1016/j.bmc.2007.10.026  PMID:18006319  PMCID:PMC2279229
    • Cheng, T. J. R., Sung, M. T., Liao, H. Y., Chang, Y. F., Chen, C. W., Huang, C. Y., Chou, L. Y., Wu, Y. D., Chen, Y., Cheng, Y. S. E., Wong, C. H., Ma, C., et al. Domain requirement of moenomycin binding to bifunctional transglycosylases and development of high-throughput discovery of antibiotics Proceedings of the National Academy of Sciences of the United States of America  2008 105:431-436  DOI:10.1073/pnas.0710868105  PMID:18182485  PMCID:PMC2206553
    • Shie, J. J., Fang, J. M., Wong, C. H. A concise and flexible synthesis of the potent anti-influenza agents tamiflu and tamiphosphor Angewandte Chemie-International Edition  2008 47:5788-5791  DOI:10.1002/anie.200801959  PMID:18613158
    • Payne, R. J., Ficht, S., Greenberg, W. A., Wong, C. H. Cysteine-free peptide and glycopeptide ligation by direct aminolysis Angewandte Chemie-International Edition  2008 47:4411-4415  DOI:10.1002/anie.200705298  PMID:18442150
    • Chang, W. W., Lee, C. H., Lee, P. S., Lin, J. W., Hsu, C. W., Hung, J. T., Lin, J. J., Yu, J. C., Shao, L. E., Wong, C. H., Yu, A. L. Expression of Globo H and SSEA3 in breast cancer stem cells and the involvement of fucosyl transferases 1 and 2 in Globo H synthesis Proceedings of the National Academy of Sciences of the United States of America  2008 105:11667-11672  DOI:10.1073/pnas.0804979105  PMID:18685093  PMCID:PMC2575305
    • Chen, M. L., Adak, A. K., Yeh, N. C., Yang, W. B., Chuang, Y. J., Wong, C. H., Hwang, K. C., Hwu, J. R. R., Hsieh, S. L., Lin, C. C. Fabrication of an oriented Fc-fused lectin microarray through boronate formation. Angewandte Chemie-International Edition  2008 47:8627-8630  DOI:10.1002/anie.200803377  PMID:18850623
    • Tseng, S. Y., Wang, C. C., Lin, C. W., Chen, C. L., Yu, W. Y., Chen, C. H., Wu, C. Y., Wong, C. H. Glycan arrays on aluminum-coated glass slides Chemistry-an Asian Journal  2008 3:1395-1405  DOI:10.1002/asia.200800154  PMID:18683161
    • Ficht, S., Payne, R. J., Guy, R. T., Wong, C. H. Solid-phase synthesis of peptide and glycopeptide thioesters through side-chain-anchoring strategies Chemistry-a European Journal  2008 14:3620-3629  DOI:10.1002/chem.200701978  PMID:18278777
    • Hanson, S. R., Greenberg, W. A., Wong, C. H. Probing glycans with the copper(i)-catalyzed 3+2 azide-alkyne cycloaddition QSAR & Combinatorial Science  2007 26:1243-1252  DOI:10.1002/qsar.200740112
    • Sugiyama, M., Hong, Z., Liang, P. H., Dean, S. M., Whalen, L. J., Greenberg, W. A., Wong, C. H. D-fructose-6-phosphate aldolase-catalyzed one-pot synthesis of iminocyclitols Journal of the American Chemical Society  2007 129:14811-14817  DOI:10.1021/ja073911i  PMID:17985886
    • Cheng, K. C., Huang, H. C., Chen, J. H., Hsu, J. W., Cheng, H. C., Ou, C. H., Yang, W. B., Chen, S. T., Wong, C. H., Juan, H. F. Ganoderma lucidum polysaccharides in human monocytic leukemia cells: From gene expression to network construction BMC Genomics  2007 8:411  DOI:10.1186/1471-2164-8-411  PMID:17996095  PMCID:PMC2211495
    • Payne, R. J., Ficht, S., Tang, S., Brik, A., Yang, Y. Y., Case, D. A., Wong, C. H. Extended sugar-assisted glycopeptide ligations: Development, scope, and applications Journal of the American Chemical Society  2007 129:13527-13536  DOI:10.1021/ja073653p  PMID:17935327
    • Polat, T., Wong, C. H. Anomeric reactivity-based one-pot synthesis of heparin-like oligosaccharides Journal of the American Chemical Society  2007 129:12795-12800  DOI:10.1021/ja073098r  PMID:17914818  PMCID:PMC2525852
    • Shie, J. J., Fang, J. M., Wang, S. Y., Tsai, K. C., Cheng, Y. S. E., Yang, A. S., Hsiao, S. C., Su, C. Y., Wong, C. H. Synthesis of tamiflu and its phosphonate congeners possessing potent anti-influenza activity Journal of the American Chemical Society  2007 129:11892-11893  DOI:10.1021/ja073992i  PMID:17850083
    • Shao, Y. M., Yang, W. B., Peng, H. P., Hsu, M. F., Tsa, K. C., Kuo, T. H., Wang, A. H. J., Liang, P. H., Yang, A. S., Wong, C. H., Lin, C. H. Structure-based design and synthesis of highly potent SARS-CoV 3CL protease inhibitors ChemBioChem  2007 8:1654-1657  DOI:10.1002/cbic.200700254  PMID:17722121
    • Liang, P. H., Wang, S. K., Wong, C. H. Quantitative analysis of carbohydrate-protein interactions using glycan microarrays: Determination of surface and solution dissociation constants Journal of the American Chemical Society  2007 129:11177-11184  DOI:10.1021/ja072931h  PMID:17705486
    • Sugiyama, M., Hong, Z. Y., Greenberg, W. A., Wong, C. H. In vivo selection for the directed evolution of l-rhamnulose aldolase from l-rhamnulose-1-phosphate aldolase (rhad) Bioorganic & Medicinal Chemistry  2007 15:5905-5911  DOI:10.1016/j.bmc.2007.05.062  PMID:17572092  PMCID:PMC1992742
    • Wei, M. T., Hua, K. F., Hsu, J., Karmenyan, A., Tseng, K. Y., Wong, C. H., Hsu, H. Y., Chiou, A. The interaction of lipopolysaccharide with membrane receptors on macrophages pre-treated with extract of reishi polysaccharides measured by optical tweezers Optics Express  2007 15:11020-11032  DOI:10.1364/oe.15.011020  PMID:19547459
    • Kaltgrad, E., Sen Gupta, S., Punna, S., Huang, C. Y., Chang, A., Wong, C. H., Finn, M. G., Blixt, O. Anti-carbohydrate antibodies elicited by polyvalent display on a viral scaffold ChemBioChem  2007 8:1455-1462  DOI:10.1002/cbic.200700225  PMID:17676704
    • Hua, K. F., Hsu, H. Y., Chao, L. K., Chen, S. T., Yang, W. B., Hsu, J., Wong, C. H. Ganoderma lucidum polysaccharides enhance cd14 endocytosis of lps and promote tlr4 signal transduction of cytokine expression Journal of Cellular Physiology  2007 212:537-550  DOI:10.1002/jcp.21050  PMID:17474083
    • Yang, Y. Y., Ficht, S., Brik, A., Wong, C. H. Sugar-assisted ligation in glycoprotein synthesis Journal of the American Chemical Society  2007 129:7690-7701  DOI:10.1021/ja0708971  PMID:17523644  PMCID:PMC2553000
    • Chang, Y. J., Huang, J. R., Tsai, Y. C., Hung, J. T., Wu, D., Fujio, M., Wong, C. H., Yu, A. L. Potent immune-modulating and anticancer effects of NKT cell stimulatory glycolipids Proceedings of the National Academy of Sciences of the United States of America  2007 104:10299-10304  DOI:10.1073/pnas.0703824104  PMID:17566107  PMCID:PMC1965507
    • Hanson, S. R., Hsu, T. L., Weerapana, E., Kishikawa, K., Simon, G. M., Cravatt, B. F., Wong, C. H. Tailored glycoproteomics and glycan site mapping using saccharide-selective bioorthogonal probes Journal of the American Chemical Society  2007 129:7266-7267  DOI:10.1021/ja0724083  PMID:17506567  PMCID:PMC2552998
    • Dean, S. M., Greenberg, W. A., Wong, C. H. Recent advances in aldolase-catalyzed asymmetric synthesis Advanced Synthesis & Catalysis  2007 349:1308-1320  DOI:10.1002/adsc.200700115
    • Michel, M. L., Keller, A. C., Paget, C., Fujio, M., Trottein, F., Savage, P. B., Wong, C. H., Schneider, E., Dy, M., Leite-De-Moraes, M. C. Identification of an il-17-producing nk1.1(neg) inkt cell population involved in airway neutrophilia Journal of Experimental Medicine  2007 204:995-1001  DOI:10.1084/jem.20061551  PMID:17470641  PMCID:PMC2118594
    • Hsu, T. L., Hanson, S. R., Kishikawa, K., Wang, S. K., Sawa, M., Wong, C. H. Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells Proceedings of the National Academy of Sciences of the United States of America  2007 104:2614-2619  DOI:10.1073/pnas.0611307104  PMID:17296930  PMCID:PMC1815231
    • Yu, Z. Q., Sawkar, A. R., Whalen, L. J., Wong, C. H., Kelly, J. W. Isofagomine- and 2,5-anhydro-2,5-imino-D-glucitol-based glucocerebrosidase pharmacological chaperones for Gaucher disease intervention Journal of Medicinal Chemistry  2007 50:94-100  DOI:10.1021/jm060677i  PMID:17201413  PMCID:PMC2543937
    • Bennett, C. S., Wong, C. H. Chemoenzymatic approaches to glycoprotein synthesis Chemical Society Reviews  2007 36:1227-1238  DOI:10.1039/b617709c  PMID:17619683
    • Thayer, D. A., Wong, C. H. Enzymatic synthesis of glycopeptides and glycoproteins Topics in Current Chemistry  2007 267:37-63  DOI:10.1007/128_032
    • Hsu, N. Y., Yang, W. B., Wong, C. H., Lee, Y. C., Lee, R. T., Wang, Y. S., Chen, C. H. Matrix-assisted laser desorption/ionization mass spectrometry of polysaccharides with 2',4',6'-trihydroxyacetophenone as matrix Rapid Communications in Mass Spectrometry  2007 21:2137-2146  DOI:10.1002/rcm.3072  PMID:17546658
    • Ficht, S., Payne, R. J., Brik, A., Wong, C. H. Second-generation sugar-assisted ligation: A method for the synthesis of cysteine-containing glycopeptides Angewandte Chemie-International Edition  2007 46:5975-5979  DOI:10.1002/anie.200700546  PMID:17607677
    • Brik, A., Wong, C. H. Sugar-assisted ligation for the synthesis of glycopeptides Chemistry-a European Journal  2007 13:5670-5675  DOI:10.1002/chem.200700330  PMID:17508364
    • Hanson, S. R., Whalen, L. J., Wong, C. H. Synthesis and evaluation of general mechanism-based inhibitors of sulfatases based on (difluoro)methyl phenyl sulfate and cyclic phenyl sulfamate motifs Bioorganic & Medicinal Chemistry  2006 14:8386-8395  DOI:10.1016/j.bmc.2006.09.002  PMID:17045481  PMCID:PMC2675284
    • Sugiyama, M., Hong, Z. Y., Whalen, L. J., Greenberg, W. A., Wong, C. H. Borate as a phosphate ester mimic in aldolase-catalyzed reactions: Practical synthesis of l-fructose and l-iminocyclitols Advanced Synthesis & Catalysis  2006 348:2555-2559  DOI:10.1002/adsc.200600356
    • Brik, A., Ficht, S., Wong, C. H. Strategies for the preparation of homogenous glycoproteins Current Opinion in Chemical Biology  2006 10:638-644  DOI:10.1016/j.cbpa.2006.10.003  PMID:17046315
    • Brik, A., Ficht, S., Yang, Y. Y., Bennett, C. S., Wong, C. H. Sugar-assisted ligation of N-linked glycopeptides with broad sequence tolerance at the ligation junction Journal of the American Chemical Society  2006 128:15026-15033  DOI:10.1021/ja065601q  PMID:17105315
    • Liu, H. T., Wong, C. H. Characterization of a transglycosylase domain of Streptococcus pneumoniae PBP1b Bioorganic & Medicinal Chemistry  2006 14:7187-7195  DOI:10.1016/j.bmc.2006.06.058  PMID:16870450
    • Cheng, Y. S. E., Lo, K. H., Hsu, H. H., Shao, Y. M., Yang, W. B., Wong, C. H., Lin, C. H. Screening for HIV protease inhibitors by protection against activity-mediated cytotoxicity in Escherichia coli Journal of Virological Methods  2006 137:82-87  DOI:10.1016/j.jviromet.2006.06.003  PMID:16849028
    • Huang, K. T., Wu, B. C., Lin, C. C., Luo, S. C., Chen, C. P., Wong, C. H. Multi-enzyme one-pot strategy for the synthesis of sialyl Lewis X-containing PSGL-1 glycopeptide Carbohydrate Research  2006 341:2151-2155  DOI:10.1016/j.carres.2006.04.047  PMID:16762328
    • Kinjo, Y., Tupin, E., Wu, D., Fujio, M., Garcia-Navarro, R., Benhnia, Mrei, Zajonc, D. M., Ben-Menachem, G., Ainge, G. D., Painter, G. F., Khurana, A., Hoebe, K., et al. Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria Nature Immunology  2006 7:978-986  DOI:10.1038/ni1380  PMID:16921381
    • Thayer, D. A., Wong, C. H. Vancomycin analogues containing monosaccharides exhibit improved antibiotic activity: A combined one-pot enzymatic glycosylation and chemical diversification strategy Chemistry-an Asian Journal  2006 1:445-452  DOI:10.1002/asia.200600084  PMID:17441081
    • Lin, K. I., Kao, Y. Y., Kuo, H. K., Yang, W. B., Chou, A., Lin, H. H., Yu, A. L., Wong, C. H. Reishi polysaccharides induce immunoglobulin production through the tlr4/tlr2-mediated induction of transcription factor blimp-1 Journal of Biological Chemistry  2006 281:24111-24123  DOI:10.1074/jbc.M601106200  PMID:16798741
    • Liang, F. S., Greenberg, W. A., Hammond, J. A., Hoffmann, J., Head, S. R., Wong, C. H. Evaluation of rna-binding specificity of aminoglycosides with DNA microarrays Proceedings of the National Academy of Sciences of the United States of America  2006 103:12311-12316  DOI:10.1073/pnas.0605264103  PMID:16891415  PMCID:PMC1567877
    • Sawa, M., Hsu, T. L., Itoh, T., Sugiyama, M., Hanson, S. R., Vogt, P. K., Wong, C. H. Glycoproteomic probes for fluorescent imaging of fucosylated glycans in vivo Proceedings of the National Academy of Sciences of the United States of America  2006 103:12371-12376  DOI:10.1073/pnas.0605418103  PMID:16895981  PMCID:PMC1567886
    • Lin, Y. C., Brik, A., de Parseval, A., Tam, K., Torbett, B. E., Wong, C. H., Elder, J. H. Altered gag polyprotein cleavage specificity of feline immunodeficiency virus/human immunodeficiency virus mutant proteases as demonstrated in a cell-based expression system Journal of Virology  2006 80:7832-7843  DOI:10.1128/jvi.00374-06  PMID:16873240  PMCID:PMC1563824
    • Sanna, M. G., Wang, S. K., Gonzalez-Cabrera, P. J., Don, A., Marsolais, D., Matheu, M. P., Wei, S. H., Parker, I., Jo, E. J., Cheng, W. C., Cahalan, M. D., Wong, C. H., et al. Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P(1) antagonist in vivo Nature Chemical Biology  2006 2:434-441  DOI:10.1038/nchembio804  PMID:16829954
    • Fujio, M., Wu, D. G., Garcia-Navarro, R., Ho, D. D., Tsuji, M., Wong, C. H. Structure-based discovery of glycolipids for CD1d-mediated NKT cell activation: Tuning the adjuvant versus immunosuppression activity Journal of the American Chemical Society  2006 128:9022-9023  DOI:10.1021/ja062740z  PMID:16834361
    • Qiu, H., Gabrielsen, A., Agardh, H. E., Wan, M., Wetterholm, A., Wong, C. H., Hedin, U., Swedenborg, J., Hansson, G. K., Samuelsson, B., Paulsson-Berne, G., Haeggstrom, J. Z. Expression of 5-lipoxygenase and leukotriene a(4) hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability Proceedings of the National Academy of Sciences of the United States of America  2006 103:8161-8166  DOI:10.1073/pnas.0602414103  PMID:16698924  PMCID:PMC1459628
    • Hsu, H. Y., Hua, K. F., Su, Y. C., Chu, L. C., Su, S. C., Chiu, H. W., Wong, C. H., Chen, S. T., Shieh, C. W., Yang, S. S., Chen, Y. M., Chao, L. K. Alkali-soluble polysaccharides of rhizoclonium riparium alga induce il-1 gene expression via protein kinase signaling pathways Journal of Agricultural and Food Chemistry  2006 54:3558-3565  DOI:10.1021/jf060442f  PMID:19127725
    • Brik, A., Yang, Y. Y., Ficht, S., Wong, C. H. Sugar-assisted glycopeptide ligation Journal of the American Chemical Society  2006 128:5626-5627  DOI:10.1021/ja061165w  PMID:16637616
    • Brigl, M., van den Elzen, P., Chen, X., Meyers, J. H., Wu, D., Wong, C. H., Reddington, F., Illarianov, P. A., Besra, G. S., Brenner, M. B., Gumperz, J. E. Conserved and heterogeneous lipid antigen specificities of CD1d-restricted NKT cell receptors Journal of Immunology  2006 176:3625-3634  PMID:16517731
    • Wu, D., Zajonc, D. M., Fujio, M., Sullivan, B. A., Kinjo, Y., Kronenberg, M., Wilson, I. A., Wong, C. H. Design of natural killer T cell activators: structure and function of a microbial glycosphingolipid bound to mouse CD1d Proceedings of the National Academy of Sciences of the United States of America  2006 103:3972-3977  DOI:10.1073/pnas.0600285103  PMID:16537470  PMCID:PMC1449630
    • Liu, L., Hong, Z. Y., Wong, C. H. Convergent glycopeptide synthesis by traceless staudinger ligation and enzymatic coupling ChemBioChem  2006 7:429-432  DOI:10.1002/cbic.200500437  PMID:16444769
    • Wu, C. Y., King, K. Y., Kuo, C. J., Fang, J. M., Wu, Y. T., Ho, M. Y., Liao, C. L., Shie, J. J., Liang, P. H., Wong, C. H. Stable benzotriazole esters as mechanism-based inactivators of the severe acute respiratory syndrome 3cl protease Chemistry & Biology  2006 13:261-268  DOI:10.1016/j.chembiol.2005.12.008  PMID:16638531
    • Chuang, M. H., Wu, M. S., Lo, W. L., Lin, J. T., Wong, C. H., Chiou, S. H. The antioxidant protein alkylhydroperoxide reductase of heliclobacter pylori switches from a peroxide reductase to a molecular chaperone function Proceedings of the National Academy of Sciences of the United States of America  2006 103:2552-2557  DOI:10.1073/pnas.0510770103  PMID:16481626  PMCID:PMC1413804
    • Liang, F. S., Brik, A., Lin, Y. C., Elder, J. H., Wong, C. H. Epoxide opening in water and screening in situ for rapid discovery of enzyme inhibitors in microtiter plates Bioorganic & Medicinal Chemistry  2006 14:1058-1062  DOI:10.1016/j.bmc.2005.09.026  PMID:16275107
    • Chow, H. F., Ng, K. F., Wang, Z. Y., Wong, C. H., Luk, T., Lo, C. M., Yang, Y. Y. Synthesis of new amphiphilic dendrons bearing aliphatic hydrocarbon surface sectors and a monocarboxylic or dicarboxylic acid focal point Organic Letters  2006 8:471-474  DOI:10.1021/ol0526928  PMID:16435862
    • Huang, C. Y., Thayer, D. A., Chang, A. Y., Best, M. D., Hoffmann, J., Head, S., Wong, C. H. Carbohydrate microarray for profiling the antibodies interacting with globo h tumor antigen Proceedings of the National Academy of Sciences of the United States of America  2006 103:15-20  DOI:10.1073/pnas.0509693102  PMID:16373501  PMCID:PMC1325001
    • Liu, L., Bennett, C. S., Wong, C. H. Advances in glycoprotein synthesis Chemical Communications  2006 21-33  DOI:10.1039/b513165k
    • Whalen, L. J., Wong, C. H. Enzymes in organic synthesis: Aldolase-mediated synthesis of iminocyclitols and novel heterocycles Aldrichimica Acta  2006 39:63-71
    • Brik, A., Wu, C. Y., Wong, C. H. Microtiter plate based chemistry and in situ screening: A useful approach for rapid inhibitor discovery Organic & Biomolecular Chemistry  2006 4:1446-1457  DOI:10.1039/b600055j  PMID:16604207
    • Liang, P. H., Cheng, W. C., Lee, Y. L., Yu, H. P., Wu, Y. T., Lin, Y. L., Wong, C. H. Novel five-membered iminocyclitol derivatives as selective and potent glycosidase inhibitors: New structures for antivirals and osteoarthritis ChemBioChem  2006 7:165-173  DOI:10.1002/cbic.200500321  PMID:16397876
    • Lee, J. C., Greenberg, W. A., Wong, C. H. Programmable reactivity-based one-pot oligosaccharide synthesis Nature Protocols  2006 1:3143-3152  DOI:10.1038/nprot.2006.489  PMID:17406577
    • Lee, J. C., Wit, C. Y., Apon, J. V., Siuzdak, G., Wong, C. H. Reactivity-based one-pot synthesis of the tumor-associated antigen n3 minor octasaccharide for the development of a photocleavable dios-ms sugar array Angewandte Chemie-International Edition  2006 45:2753-2757  DOI:10.1002/anie.200504067  PMID:16548041
    • Hong, Z. Y., Liu, L., Hsu, C. C., Wong, C. H. Three-step synthesis of sialic acids and derivatives Angewandte Chemie-International Edition  2006 45:7417-7421  DOI:10.1002/anie.200601555  PMID:17031889
    • Zajonc, D. M., Maricic, I., Wu, D., Halder, R., Roy, K., Wong, C. H., Kumar, V., Wilson, I. A. Structural basis for CD1d presentation of a sulfatide derived from myelin and its implications for autoimmunity Journal of Experimental Medicine  2005 202:1517-1526  DOI:10.1084/jem.20051625  PMID:16314439  PMCID:PMC2213337
    • Wei, S. H., Rosen, H., Matheu, M. P., Sanna, M. G., Wang, S. K., Jo, E. J., Wong, C. H., Parker, I., Cahalan, M. D. Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary t cells to lymphatic sinuses Nature Immunology  2005 6:1228-1235  DOI:10.1038/ni1269  PMID:16273098
    • Wu, C. Y., Brik, A., Wang, S. K., Chen, Y. H., Wong, C. H. Tetrabutylammonium fluoride-mediated rapid alkylation reaction in microtiter plates for the discovery of enzyme inhibitors in situ ChemBioChem  2005 6:2176-2180  DOI:10.1002/cbic.200500295  PMID:16270365
    • Sawkar, A. R., Adamski-Werner, S. L., Cheng, W. C., Wong, C. H., Beutler, E., Zimmer, K. P., Kelly, J. W. Gaucher disease-associated glucocerebrosidases show mutation-dependent chemical chaperoning profiles Chemistry & Biology  2005 12:1235-1244  DOI:10.1016/j.chembiol.2005.09.007  PMID:16298303
    • Calarese, D. A., Lee, H. K., Huang, C. Y., Best, M. D., Astronomo, R. D., Stanfield, R. L., Katinger, H., Burton, D. R., Wong, C. H., Wilson, I. A. Dissection of the carbohydrate specificity of the broadly neutralizing-anti-hiv-1 antibody 2g12 Proceedings of the National Academy of Sciences of the United States of America  2005 102:13372-13377  DOI:10.1073/pnas.0505763102  PMID:16174734  PMCID:PMC1224641
    • Shie, J. J., Fang, J. M., Kuo, T. H., Kuo, C. J., Liang, P. H., Huang, H. J., Wu, Y. T., Jan, J. T., Cheng, Y. S. E., Wong, C. H. Inhibition of the severe acute respiratory syndrome 3cl protease by peptidomimetic alpha,beta-unsaturated esters Bioorganic & Medicinal Chemistry  2005 13:5240-5252  DOI:10.1016/j.bmc.2005.05.065  PMID:15994085
    • Brik, A., Wu, C. Y., Best, M. D., Wong, C. H. Tetrabutylammonium fluoride-assisted rapid n-9-alkylation on purine ring: Application to combinatorial reactions in microtiter plates for the discovery of potent sulfotransferase inhibitors in situ Bioorganic & Medicinal Chemistry  2005 13:4622-4626  DOI:10.1016/j.bmc.2005.02.066  PMID:15953729
    • Brik, A., Alexandratos, J., Lin, Y. C., Elder, J. H., Olson, A. J., Wlodawer, A., Goodsell, D. S., Wong, C. H. 1,2,3-triazole as a peptide surrogate in the rapid synthesis of HIV-1 protease inhibitors ChemBioChem  2005 6:1167-1169  DOI:10.1002/cbic.200500101  PMID:15934050
    • Shie, J. J., Fang, J. M., Kuo, C. J., Kuo, T. H., Liang, P. H., Huang, H. J., Yang, W. B., Lin, C. H., Chen, J. L., Wu, Y. T., Wong, C. H. Discovery of potent anilide inhibitors against the severe acute respiratory syndrome 3CL protease Journal of Medicinal Chemistry  2005 48:4469-4473  DOI:10.1021/jm050184y  PMID:15974598
    • Hsu, C. C., Hong, Z. Y., Wada, M., Franke, D., Wong, C. H. Directed evolution of d-sialic acid aldolase to l-3-deoxy-manno-2-octulosonic acid (l-kdo) aldolase Proceedings of the National Academy of Sciences of the United States of America  2005 102:9122-9126  DOI:10.1073/pnas.0504033102  PMID:15967977  PMCID:PMC1166642
    • Numa, M. M. D., Lee, L. V., Hsu, C. C., Bower, K. E., Wong, C. H. Identification of novel anthrax lethal factor inhibitors generated by combinatorial pictet-spengler reaction followed by screening in situ ChemBioChem  2005 6:1002-1006  DOI:10.1002/cbic.20050000  PMID:15880659
    • Wong, C. H. Protein glycosylation: New challenges and opportunities Journal of Organic Chemistry  2005 70:4219-4225  DOI:10.1021/jo050278f  PMID:15903293
    • Xing, G. W., Wu, D., Poles, M. A., Horowitz, A., Tsuji, M., Ho, D. D., Wong, C. H. Synthesis and human NKT cell stimulating properties of 3-O-sulfo-α/β-galactosylceramides Bioorganic & Medicinal Chemistry  2005 13:2907-2916  DOI:10.1016/j.bmc.2005.02.018  PMID:15781400
    • Kinjo, Y., Wu, D., Kim, G. S., Xing, G. W., Poles, M. A., Ho, D. D., Tsuji, M., Kawahara, K., Wong, C. H., Kronenberg, M. Recognition of bacterial glycosphingolipids by natural killer T cells Nature  2005 434:520-525  DOI:10.1038/nature03407  PMID:15791257
    • Sinchaikul, S., Pan, F. M., Cheng, C. W., Wong, C. H., Fang, J. M., Tseng, M. J., Chen, S. T. Protein microarray using alpha-amino acids as metal tags on chips Bioorganic & Medicinal Chemistry Letters  2005 15:1413-1416  DOI:10.1016/j.bmcl.2005.01.001  PMID:15713398
    • Fan, G. T., Pan, Y. S., Lu, K. C., Cheng, Y. P., Lin, W. C., Lin, S., Lin, C. H., Wong, C. H., Fang, J. M., Lin, C. C. Synthesis of α-galactosyl ceramide and the related glycolipids for evaluation of their activities on mouse splenocytes Tetrahedron  2005 61:1855-1862  DOI:10.1016/j.tet.2004.12.027
    • Tolbert, T. J., Franke, D., Wong, C. H. A new strategy for glycoprotein synthesis: ligation of synthetic glycopeptides with truncated proteins expressed in E. coli as TEV protease cleavable fusion protein Bioorganic & Medicinal Chemistry  2005 13:909-915  DOI:10.1016/j.bmc.2004.06.047  PMID:15653356
    • Wu, D., Xing, G. W., Poles, M. A., Horowitz, A., Kinjo, Y., Sullivan, B., Bodmer-Narkevitch, V., Plettenburg, O., Kronenberg, M., Tsuji, M., Ho, D. D., Wong, C. H. Bacterial glycolipids and analogs as antigens for CD1d-restricted NKT cells Proceedings of the National Academy of Sciences of the United States of America  2005 102:1351-1356  DOI:10.1073/pnas.0408696102  PMID:15665086  PMCID:PMC547854
    • Thayer, D. A., Yu, H. N., Galan, M. C., Wong, C. H. A general strategy toward s-linked glycopeptides Angewandte Chemie-International Edition  2005 44:4596-4599  DOI:10.1002/anie.200500090  PMID:15991213
    • Scanlan, C., Lee, H. K., Blixt, O., Wong, C. H., Wilson, I., Burton, D., Dwek, R., Rudd, P. Antibody recognition of a carbohydrate epitope: a template for HIV vaccine design Advances in Experimental Medicine and Biology  2005 564:7-8  DOI:10.1007/0-387-25515-X_4  PMID:16400800
    • Fridman, M., Belakhov, V., Lee, L. V., Liang, F. S., Wong, C. H., Baasov, T. Dual effect of synthetic aminoglycosides: Antibacterial activity against bacillus anthracis and inhibition of anthrax lethal factor Angewandte Chemie-International Edition  2005 44:447-452  DOI:10.1002/anie.200462003  PMID:15624157
    • Mocharla, V. P., Colasson, B., Lee, L. V., Roper, S., Sharpless, K. B., Wong, C. H., Kolb, H. C. In situ click chemistry: Enzyme-generated inhibitors of carbonic anhydrase ii Angewandte Chemie-International Edition  2005 44:116-120  DOI:10.1002/anie.200461580
    • Nyffeler, P. T., Duron, S. G., Burkart, M. D., Vincent, S. P., Wong, C. H. Selectfluor: Mechanistic insight and applications Angewandte Chemie-International Edition  2005 44:192-212  DOI:10.1002/anie.200400648
    • Chen, J. H., Chang, Y. W., Yao, C. W., Chiueh, T. S., Huang, S. C., Chien, K. Y., Chen, A., Chang, F. Y., Wong, C. H., Chen, Y. J. Plasma proteome of severe acute respiratory syndrome analyzed by two-dimensional gel electrophoresis and mass spectrometry Proceedings of the National Academy of Sciences of the United States of America  2004 101:17039-17044  DOI:10.1073/pnas.0407992101  PMID:15572443  PMCID:PMC535397
    • Blixt, O., Head, S., Mondala, T., Scanlan, C., Huflejt, M. E., Alvarez, R., Bryan, M. C., Fazio, F., Calarese, D., Stevens, J., Razi, N., Stevens, D. J., et al. Printed covalent glycan array for ligand profiling of diverse glycan binding proteins Proceedings of the National Academy of Sciences of the United States of America  2004 101:17033-17038  DOI:10.1073/pnas.0407902101  PMID:15563589  PMCID:PMC534418
    • Hanson, S., Best, M., Bryan, M. C., Wong, C. H. Chemoenzymatic synthesis of oligosaccharides and glycoproteins Trends in Biochemical Sciences  2004 29:656-663  DOI:10.1016/j.tibs.2004.10.004  PMID:15544952
    • Lin, H., Thayer, D. A., Wong, C. H., Walsh, C. T. Macrolactamization of glycosylated peptide thioesters by the thioesterase domain of tyrocidine synthetase Chemistry & Biology  2004 11:1635-1642  DOI:10.1016/j.chembiol.2004.09.015  PMID:15610847
    • Hsu, H. Y., Hua, K. F., Lin, C. C., Lin, C. H., Hsu, J., Wong, C. H. Extract of Reishi polysaccharides induces cytokine expression via TLR4-modulated protein kinase signaling pathways Journal of Immunology  2004 173:5989-5999  PMID:15528333
    • Chien, C. A., Cheng, J. L., Chang, W. T., Tien, M. H., Tsao, C. M., Chang, Y. H., Chang, H. Y., Hsieh, J. F., Wong, C. H., Chen, S. T. Polysaccharides of ganoderma lucidum alter cell immunophenotypic expression and enhance cd56(+) nk-cell cytotoxicity in cord blood Bioorganic & Medicinal Chemistry  2004 12:5603-5609  DOI:10.1016/j.bmc.2004.08.004  PMID:15465338
    • Chen, H. S., Tsai, Y. F., Lin, S., Lin, C. C., Khoo, K. H., Lin, C. H., Wong, C. H. Studies on the immuno-modulating and anti-tumor activities of Ganoderma lucidum (Reishi) polysaccharides Bioorganic & Medicinal Chemistry  2004 12:5595-5601  DOI:10.1016/j.bmc.2004.08.003  PMID:15465337
    • Heine, A., Luz, J. G., Wong, C. H., Wilson, I. A. Analysis of the class i aldolase binding site architecture based on the crystal structure of 2-deoxyribose-5-phosphate aldolase at 0.99 Å resolution Journal of Molecular Biology  2004 343:1019-1034  DOI:10.1016/j.jmb.2004.08.066  PMID:15476818
    • Liu, J., Numa, M. M. D., Liu, H. T., Huang, S. J., Sears, P., Shikhman, A. R., Wong, C. H. Synthesis and high-throughput screening of N-acetyl-β-hexosaminidase inhibitor libraries targeting osteoarthritis Journal of Organic Chemistry  2004 69:6273-6283  DOI:10.1021/jo049355h  PMID:15357586
    • Bryan, M. C., Fazio, F., Lee, H. K., Huang, C. Y., Chang, A., Best, M. D., Calarese, D. A., Blixt, C., Paulson, J. C., Burton, D., Wilson, I. A., Wong, C. H. Covalent display of oligosaccharide arrays in microtiter plates Journal of the American Chemical Society  2004 126:8640-8641  DOI:10.1021/ja048433f  PMID:15250702
    • Wu, C. Y., Jan, J. T., Ma, S. H., Kuo, C. J., Juan, H. F., Cheng, Y. S. E., Hsu, H. H., Huang, H. C., Wu, D., Brik, A., Liang, F. S., Liu, R. S., et al. Small molecules targeting severe acute respiratory syndrome human coronavirus Proceedings of the National Academy of Sciences of the United States of America  2004 101:10012-10017  DOI:10.1073/pnas.0403596101  PMID:15226499  PMCID:PMC454157
    • Cheng, T. J., Brik, A., Wong, C. H., Kan, C. C. Model system for high-throughput screening of novel human immunodeficiency virus protease inhibitors in escherichia coli Antimicrobial Agents and Chemotherapy  2004 48:2437-2447  DOI:10.1128/aac.48.7.2437-2447.2004  PMID:15215092
    • Bryan, M. C., Lee, L. V., Wong, C. H. High-throughput identification of fucosyltransferase inhibitors using carbohydrate microarrays Bioorganic & Medicinal Chemistry Letters  2004 14:3185-3188  DOI:10.1016/j.bmcl.2004.04.001  PMID:15149672
    • Best, M. D., Brik, A., Chapman, E., Lee, L. V., Cheng, W. C., Wong, C. H. Rapid discovery of potent sulfotransferase inhibitors by diversity-oriented reaction in microplates followed by in situ screening ChemBioChem  2004 5:811-819  DOI:10.1002/cbic.200300841  PMID:15174164
    • Klostermeier, D., Sears, P., Wong, C. H., Millar, D. P., Williamson, J. R. A three-fluorophore FRET assay for high-throughput screening of small-molecule inhibitors of ribosome assembly Nucleic Acids Research  2004 32:2707-2715  DOI:10.1093/nar/gkh588  PMID:15148358  PMCID:PMC419595
    • Bryan, M. C., Wong, C. H. Aminoglycoside array for the high-throughput analysis of small molecule-rna interactions Tetrahedron Letters  2004 45:3639-3642  DOI:10.1016/j.tetlet.2004.03.035
    • Lee, L. V., Bower, K. E., Liang, F. S., Shi, J., Wu, D., Sucheck, S. J., Vogt, P. K., Wong, C. H. Inhibition of the proteolytic activity of anthrax lethal factor by aminoglycosides Journal of the American Chemical Society  2004 126:4774-4775  DOI:10.1021/ja0495359  PMID:15080670
    • Cheng, C. W., Lin, K. C., Pan, F. M., Sinchaikul, S., Wong, C. H., Su, W. C., Hsu, C. H., Chen, S. T. Facile synthesis of metal-chelating peptides on chip for protein array Bioorganic & Medicinal Chemistry Letters  2004 14:1987-1990  DOI:10.1016/j.bmcl.2004.01.084  PMID:15050643
    • Fazio, F., Bryan, M. C., Lee, H. K., Chang, A., Wong, C. H. Assembly of sugars on polystyrene plates: A new facile microarray fabrication technique Tetrahedron Letters  2004 45:2689-2692  DOI:10.1016/j.tetlet.2004.01.159
    • Liu, J., Hsu, C. C., Wong, C. H. Sequential aldol condensation catalyzed by dera mutant ser238asp and a formal total synthesis of atorvastatin Tetrahedron Letters  2004 45:2439-2441  DOI:10.1016/j.teltet.2004.01.110
    • Duron, S. G., Polat, T., Wong, C. H. N-(phenylthio)-epsilon-caprolactam: A new promoter for the activation of thioglycosides Organic Letters  2004 6:839-841  DOI:10.1021/ol0400084  PMID:14986988
    • Yu, H. N., Furukawa, J., Ikeda, T., Wong, C. H. Novel efficient routes to heparin monosaccharides and disaccharides achieved via regio- and stereoselective glycosidation Organic Letters  2004 6:723-726  DOI:10.1021/ol036390m  PMID:14986959
    • Heck, M. P., Vincent, S. P., Murray, B. W., Bellamy, F., Wong, C. H., Mioskowski, C. Cyclic amidine sugars as transition-state analogue inhibitors of glycosidases: Potent competitive inhibitors of mannosidases Journal of the American Chemical Society  2004 126:1971-1979  DOI:10.1021/ja037822r  PMID:14971930
    • Chou, C. H., Wu, C. S., Chen, C. H., Lu, L. D., Kulkarni, S. S., Wong, C. H., Hung, S. C. Regioselective glycosylation of neamine core: A facile entry to kanamycin b related analogues Organic Letters  2004 6:585-588  DOI:10.1021/ol0363927  PMID:14961629
    • Zhang, Z. W., Gildersleeve, J., Yang, Y. Y., Xu, R., Loo, J. A., Uryu, S., Wong, C. H., Schultz, P. G. A new strategy for the synthesis of glycoproteins Science  2004 303:371-373  DOI:10.1126/science.1089509  PMID:14726590
    • Nyffeler, P. T., Boyle, N. A., Eltepu, L., Wong, C. H., Eschenmoser, A., Lerner, R. A., Wentworth, P. Dihydrogen trioxide (hoooh) is generated during the thermal reaction between hydrogen peroxide and ozone Angewandte Chemie-International Edition  2004 43:4656-4659  DOI:10.1002/anie.200460457  PMID:15317003
    • Agnelli, T., Sucheck, S. J., Marby, K. A., Rabuka, D., Yao, S. L., Sears, P. S., Liang, F. S., Wong, C. H. Dimeric aminoglycosides as antibiotics Angewandte Chemie-International Edition  2004 43:1562-1566  DOI:10.1002/anie.200353225  PMID:15022234
    • Chang, C. F., Ho, C. W., Wu, C. Y., Chao, T. A., Wong, C. H., Lin, C. H. Discovery of picomolar slow tight-binding inhibitors of α-fucosidase Chemistry & Biology  2004 11:1301-1306  DOI:10.1016/j.chembiol.2004.07.009  PMID:15380190
    • Lee, H. K., Scanlan, C. N., Huang, C. Y., Chang, A. Y., Calarese, D. A., Dwek, R. A., Rudd, P. M., Burton, D. R., Wilson, I. A., Wong, C. H. Reactivity-based one-pot synthesis of oligomannoses: Defining antigens recognized by 2g12, a broadly neutralizing anti-hiv-1 antibody Angewandte Chemie-International Edition  2004 43:1000-1003  DOI:10.1002/anie.200353105  PMID:14966891
    • Hanson, S. R., Best, M. D., Wong, C. H. Sulfatases: Structure, mechanism, biological activity, inhibition, and synthetic utility Angewandte Chemie-International Edition  2004 43:5736-5763  DOI:10.1002/anie.200300632  PMID:15493058
    • Chapman, E., Best, M. D., Wong, C. H., Hanson, S. R. Sulfotransferases: Structure, mechanism, biological activity, inhibition, and synthetic utility Angewandte Chemie-International Edition  2004 43:3526-3548  DOI:10.1002/anie.200300631  PMID:15293241
    • Liang, F. S., Wang, S. K., Nakatani, T., Wong, C. H. Targeting RNAs with tobramycin analogues Angewandte Chemie-International Edition  2004 43:6496-6500  DOI:10.1002/anie.200460558  PMID:15578772
    • Fazio, F., Wong, C. H. Rucl3-promoted amide formation from azides and thioacids Tetrahedron Letters  2003 44:9083-9085  DOI:10.1016/j.tetlet.2003.10.054
    • Brik, A., Muldoon, J., Lin, Y. C., Elder, J. H., Goodsell, D. S., Olson, A. J., Fokin, V. V., Sharpless, K. B., Wong, C. H. Rapid diversity-oriented synthesis in microtiter plates for in situ screening of HIV protease inhibitors ChemBioChem  2003 4:1246-1248  DOI:10.1002/cbic.200300724  PMID:14613121
    • Feizi, T., Fazio, F., Chai, W. C., Wong, C. H. Carbohydrate microarrays - a new set of technologies at the frontiers of glycomics Current Opinion in Structural Biology  2003 13:637-645  DOI:10.1016/j.sbi.2003.09.002  PMID:14568620
    • Franke, D., Machajewski, T., Hsu, C. C., Wong, C. H. One-pot synthesis of l-fructose using coupled multienzyme systems based on rhamnulose-1-phosphate aldolase Journal of Organic Chemistry  2003 68:6828-6831  DOI:10.1021/jo030021m  PMID:12919060
    • Lee, L. V., Mitchell, M. L., Huang, S. J., Fokin, V. V., Sharpless, K. B., Wong, C. H. A potent and highly selective inhibitor of human α-1,3-fucosyltransferase via click chemistry Journal of the American Chemical Society  2003 125:9588-9589  DOI:10.1021/ja0302836  PMID:12904015
    • Liu, H., Ritter, T. K., Sadamoto, R., Sears, P. S., Wu, M., Wong, C. H. Acceptor specificity and inhibition of the bacterial cell-wall glycosyltransferase murg ChemBioChem  2003 4:603-609  DOI:10.1002/cbic.200300557  PMID:12851929
    • Mak, C. C., Brik, A., Lerner, D. L., Elder, J. H., Morris, G. M., Olson, A. J., Wong, C. H. Design and synthesis of broad-based mono- and bi-cyclic inhibitors of FIV and HIV proteases Bioorganic & Medicinal Chemistry  2003 11:2025-2040  DOI:10.1016/s0968-0896(03)00054-3  PMID:12670654
    • Wada, M., Hsu, C. C., Franke, D., Mitchell, M., Heine, A., Wilson, I., Wong, C. H. Directed evolution of N-acetylneuraminic acid aldolase to catalyze enantiomeric aldol reactions Bioorganic & Medicinal Chemistry  2003 11:2091-2098  DOI:10.1016/s0968-0896(03)00052-x  PMID:12670660
    • Mong, T. K. K., Huang, C. Y., Wong, C. H. A new reactivity-based one-pot synthesis of n-acetyllactosamine oligomers Journal of Organic Chemistry  2003 68:2135-2142  DOI:10.1021/jo0206420  PMID:12636372
    • Liu, H. T., Wang, L., Brock, A., Wong, C. H., Schultz, P. G. A method for the generation of glycoprotein mimetics Journal of the American Chemical Society  2003 125:1702-1703  DOI:10.1021/ja029433n  PMID:12580587
    • Chapman, E., Bryan, M. C., Wong, C. H. Mechanistic studies of beta-arylsulfotransferase iv Proceedings of the National Academy of Sciences of the United States of America  2003 100:910-915  DOI:10.1073/pnas.0337638100  PMID:12547913  PMCID:PMC298700
    • Mong, T. K. K., Lee, H. K., Duron, S. G., Wong, C. H. Reactivity-based one-pot total synthesis of fucose gm(1) oligosaccharide: A sialylated antigenic epitope of small-cell lung cancer Proceedings of the National Academy of Sciences of the United States of America  2003 100:797-802  DOI:10.1073/pnas.0337590100  PMID:12552090  PMCID:PMC298681
    • Wong, C. H., Bryan, M. C., Nyffeler, P. T., Liu, H. T., Chapman, E. Synthesis of carbohydrate-based antibiotics Pure and Applied Chemistry  2003 75:179-186  DOI:10.1351/pac200375020179
    • Brik, A., Wong, C. H. HIV-1 protease: Mechanism and drug discovery Organic & Biomolecular Chemistry  2003 1:5-14  DOI:10.1039/b208248a  PMID:12929379
    • DeSantis, G., Liu, J., Clark, D. P., Heine, A., Wilson, I. A., Wong, C. H. Structure-based mutagenesis approaches toward expanding the substrate specificity of d-2-deoxyribose-5-phosphate aldolase Bioorganic & Medicinal Chemistry  2003 11:43-52  DOI:10.1016/s0968-0896(02)00429-7  PMID:12467706
    • Ritter, T. K., Mong, K. K. T., Liu, H. T., Nakatani, T., Wong, C. H. A programmable one-pot oligosaccharide synthesis for diversifying the sugar domains of natural products: A case study of vancomycin Angewandte Chemie-International Edition  2003 42:4657-4660  DOI:10.1002/anie.200351534  PMID:14533156
    • Silvestri, M. G., Desantis, G., Mitchell, M., Wong, C. H. Asymmetric aldol reactions using aldolases Topics in Stereochemistry  2003 23:267-342
    • Wu, C. Y., Chang, C. F., Chen, J. S. Y., Wong, C. H., Lin, C. H. Rapid diversity-oriented synthesis in microtiter plates for in situ screening: Discovery of potent and selective α-fucosidase inhibitors Angewandte Chemie-International Edition  2003 42:4661-4664  DOI:10.1002/anie.200351823  PMID:14533157
    • Wong, C. H., Bryan, M. C. Sugar arrays in microtiter plates Recognition of Carbohydrates in Biological Systems Pt A: General Procedures  2003 362:218-225  PMID:12968366
    • Wong, C. H., Liang, F. S. Surface plasmon resonance study of RNA-aminoglycoside interactions Recognition of Carbohydrates in Biological Systems Pt A: General Procedures  2003 362:340-353  PMID:12968375
    • Chapman, E., Ding, S., Schultz, P. G., Wong, C. H. A potent and highly selective sulfotransferase inhibitor Journal of the American Chemical Society  2002 124:14524-14525  DOI:10.1021/ja021086u  PMID:12465948
    • Fazio, F., Bryan, M. C., Blixt, O., Paulson, J. C., Wong, C. H. Synthesis of sugar arrays in microtiter plate Journal of the American Chemical Society  2002 124:14397-14402  DOI:10.1021/ja020887u  PMID:12452714
    • Sawkar, A. R., Cheng, W. C., Beutler, E., Wong, C. H., Balch, W. E., Kelly, J. W. Chemical chaperones increase the cellular activity of N370S beta-glucosidase: a therapeutic strategy for Gaucher disease Proceedings of the National Academy of Sciences of the United States of America  2002 99:15428-15433  DOI:10.1073/pnas.192582899  PMID:12434014  PMCID:PMC137733
    • Nyffeler, P. T., Liang, C. H., Koeller, K. M., Wong, C. H. The chemistry of amine-azide interconversion: Catalytic diazotransfer and regioselective azide reduction Journal of the American Chemical Society  2002 124:10773-10778  DOI:10.1021/ja0264605  PMID:12207533
    • Sadamoto, R., Niikura, K., Sears, P. S., Liu, H. T., Wong, C. H., Suksomcheep, A., Tomita, F., Monde, K., Nishimura, S. I. Cell-wall engineering of living bacteria Journal of the American Chemical Society  2002 124:9018-9019  DOI:10.1021/ja026133x  PMID:12148983
    • Zhang, Z. Y., Wong, C. H. Regioselective benzoylation of sugars mediated by excessive bu2sno: Observation of temperature promoted migration Tetrahedron  2002 58:6513-6519  DOI:10.1016/s0040-4020(02)00661-0
    • Mitchell, M. L., Lee, L. V., Wong, C. H. Synthesis and evaluation of six-membered GDP-iminocyclitol Tetrahedron Letters  2002 43:5691-5693  DOI:10.1016/s0040-4039(02)01108-5
    • Brik, A., Lin, Y. C., Elder, J., Wong, C. H. A quick diversity-oriented amide-forming reaction to optimize p-subsite residues of hiv protease inhibitors Chemistry & Biology  2002 9:891-896  DOI:10.1016/s1074-5521(02)00184-9  PMID:12204688
    • Zhang, Z. Y., Niikura, K., Huang, X. F., Wong, C. H. A strategy for the one-pot synthesis of sialylated oligosaccharides Canadian Journal of Chemistry-Revue Canadienne De Chimie  2002 80:1051-1054  DOI:10.1139/v02-131
    • Thunnissen, Mmgm, Andersson, B., Samuelsson, B., Wong, C. H., Haeggstrom, J. Z. Crystal structures of leukotriene a(4) hydrolase in complex with captopril and two competitive tight-binding inhibitors FASEB Journal  2002 16:1648-1650  DOI:10.1096/fj.01-1017fje  PMID:12207002
    • Plettenburg, O., Mui, C., Bodmer-Narkevitch, V., Wong, C. H. Rapid preparation of glycolipid libraries by cross metathesis Advanced Synthesis & Catalysis  2002 344:622-626  DOI:10.1002/1615-4169(200208)344:6/7<622::aid-adsc622>3.0.co;2-w
    • Plettenburg, O., Bodmer-Narkevitch, V., Wong, C. H. Synthesis of alpha-galactosyl ceramide, a potent immunostimulatory agent Journal of Organic Chemistry  2002 67:4559-4564  DOI:10.1021/jo0201530  PMID:12076157
    • Bryan, M. C., Plettenburg, O., Sears, P., Rabuka, D., Wacowich-Sgarbi, S., Wong, C. H. Saccharide display on microtiter plates Chemistry & Biology  2002 9:713-720  DOI:10.1016/s1074-5521(02)00155-2  PMID:12079783
    • Liu, J., DeSantis, G., Wong, C. H. Structure-based rationalization of aldolase-catalyzed asymmetric synthesis Canadian Journal of Chemistry-Revue Canadienne De Chimie  2002 80:643-645  DOI:10.1139/v02-094
    • Liu, J., Wong, C. H. An efficient method for the cleavage of p-methoxybenzylidene (PMP), tetrahydropyranyl (THP) and 1,3-dithiane protecting groups by Selectfluor™ Tetrahedron Letters  2002 43:4037-4039  DOI:10.1016/s0040-4039(02)00740-2
    • Liu, J., Wong, C. H. Selectfluor ™-mediated allylstannation of aldehydes and imines Tetrahedron Letters  2002 43:3915-3917  DOI:10.1016/s0040-4039(02)00640-8
    • Liu, J., Huang, C. Y., Wong, C. H. An efficient method for the preparation of 2-hydroxy- and 2-aminoglycals from glycosyl sulfoxides Tetrahedron Letters  2002 43:3447-3448  DOI:10.1016/s0040-4039(02)00555-5
    • Kanemitsu, T., Wong, C. H., Kanie, O. Solid-phase synthesis of oligosaccharides and on-resin quantitative monitoring using gated decoupling c-13 NMR Journal of the American Chemical Society  2002 124:3591-3599  DOI:10.1021/ja0167396  PMID:11929248
    • Wang, Y. Y., Khoo, K. H., Chen, S. T., Lin, C. C., Wong, C. H., Lin, C. H. Studies on the immuno-modulating and antitumor activities of Ganoderma lucidum (Reishi) polysaccharides: functional and proteomic analyses of a fucose-containing glycoprotein fraction responsible for the activities Bioorganic & Medicinal Chemistry  2002 10:1057-1062  DOI:10.1016/s0968-0896(01)00377-7  PMID:11836115
    • Chapman, E., Wong, C. H. A ph sensitive colorometric assay for the high-throughput screening of enzyme inhibitors and substrates: A case study using kinases Bioorganic & Medicinal Chemistry  2002 10:551-555  DOI:10.1016/s0968-0896(01)00306-6  PMID:11814841
    • Guo, C. T., Sun, X. L., Kanie, O., Shortridge, K. F., Suzuki, T., Miyamoto, D., Hidari, Kipj, Wong, C. H., Suzuki, Y. An o-glycoside of sialic acid derivative that inhibits both hemagglutinin and sialidase activities of influenza viruses Glycobiology  2002 12:183-190  DOI:10.1093/glycob/12.3.183  PMID:11971862
    • Demura, M., Noda, M., Kajimoto, T., Uchiyama, T., Umemoto, K., Wong, C. H., Asakura, T. Solution structure of sialyl lewis x mimics studied by two-dimensional NMR Journal of Molecular Structure  2002 602:215-222  DOI:10.1016/s0022-2860(01)00678-0
    • Liu, J., Wong, C. H. Aldolase-catalyzed asymmetric synthesis of novel pyranose synthons as a new entry to heterocycles and epothilones Angewandte Chemie-International Edition  2002 41:1404-1407  DOI:10.1002/1521-3773(20020415)41:8<1404::aid-anie1404>3.0.co;2-g  PMID:19750780
    • Wong, C. K., White, H. D., Wilcox, R. G., Criger, D. A., Califf, R. M., Topol, E. J., Ohman, E. M., GUSTO III Investigators Management and outcome of patients with atrial fibrillation during acute myocardial infarction: the GUSTO-III experience. Global use of strategies to open occluded coronary arteries Heart  2002 88:357-362  DOI:10.1136/heart.88.4.357  PMID:12231591  PMCID:PMC1767360
    • Tolbert, T. J., Wong, C. H. New methods for proteomic research: Preparation of proteins with n-terminal cysteines for labeling and conjugation Angewandte Chemie-International Edition  2002 41:2171-2174  DOI:10.1002/1521-3773(20020617)41:12<2171::aid-anie2171>3.0.co;2-q  PMID:19746634
    • Mong, K. K. T., Wong, C. H. Reactivity-based one-pot synthesis of a lewis y carbohydrate hapten: A colon-rectal cancer antigen determinant Angewandte Chemie-International Edition  2002 41:4087-4090  DOI:10.1002/1521-3773(20021104)41:21<4087::aid-anie4087>3.0.co;2-x  PMID:12412090
    • Mitchell, M. L., Tian, F., Lee, L. V., Wong, C. H. Synthesis and evaluation of transition-state analogue inhibitors of α-1,3-fucosyltransferase Angewandte Chemie-International Edition  2002 41:3041-3044  DOI:10.1002/1521-3773(20020816)41:16<3041::aid-anie3041>3.0.co;2-v  PMID:12203452
    • Izumi, M., Shen, G. J., Wacowich-Sgarbi, S., Nakatani, T., Plettenburg, O., Wong, C. H. Microbial glycosyltransferases for carbohydrate synthesis: Alpha-2,3-sialyltransferase from neisseria gonorrheae Journal of the American Chemical Society  2001 123:10909-10918  DOI:10.1021/ja011382r  PMID:11686694
    • Saotome, C., Wong, C. H., Kanie, O. Combinatorial library of five-membered iminocyclitol and the inhibitory activities against glyco-enzymes Chemistry & Biology  2001 8:1061-1070  DOI:10.1016/s1074-5521(01)00074-6  PMID:11731297
    • Heine, A., DeSantis, G., Luz, J. G., Mitchell, M., Wong, C. H., Wilson, I. A. Observation of covalent intermediates in an enzyme mechanism at atomic resolution Science  2001 294:369-374  DOI:10.1126/science.1063601  PMID:11598300
    • Liu, H. T., Sadamoto, R., Sears, P. S., Wong, C. H. An efficient chemoenzymatic strategy for the synthesis of wild-type and vancomycin-resistant bacterial cell-wall precursors: UDP-N-acetylmuramyl-peptides Journal of the American Chemical Society  2001 123:9916-9917  DOI:10.1021/ja011708w  PMID:11583564
    • Kozlov, I. A., Mao, S. L., Xu, Y., Huang, X. F., Lee, L., Sears, P. S., Gao, C., Coyle, A. R., Janda, K. D., Wong, C. H. Synthesis of solid-supported mirror-image sugars: A novel method for selecting receptors for cellular-surface carbohydrates ChemBioChem  2001 2:741-746  DOI:10.1002/1439-7633(20011001)2:10<741::aid-cbic741>3.0.co;2-b  PMID:11948856
    • Buhler, B., Lin, Y. C., Morris, G., Olson, A. J., Wong, C. H., Richman, D. D., Elder, J. H., Torbett, B. E. Viral evolution in response to the broad-based retroviral protease inhibitor TL-3 Journal of Virology  2001 75:9502-9508  DOI:10.1128/jvi.75.19.9502-9508.2001  PMID:11533212  PMCID:PMC114517
    • Mitchell, M., Qaio, L., Wong, C. H. Chemical-enzymatic synthesis of iminocyclitol phosphonic acids Advanced Synthesis & Catalysis  2001 343:596-599  DOI:10.1002/1615-4169(200108)343:6/7<596::aid-adsc596>3.0.co;2-v
    • Huang, X. F., Witte, K. L., Bergbreiter, D. E., Wong, C. H. Homogenous enzymatic synthesis using a thermo-responsive water-soluble polymer support Advanced Synthesis & Catalysis  2001 343:675-681  DOI:10.1002/1615-4169(200108)343:6/7<675::aid-adsc675>3.0.co;2-2
    • Liu, J., Shikhman, A. R., Lotz, M. K., Wong, C. H. Hexosaminidase inhibitors as new drug candidates for the therapy of osteoarthritis Chemistry & Biology  2001 8:701-711  DOI:10.1016/s1074-5521(01)00045-x  PMID:11451670
    • Izumi, M., Wong, C. H. Microbial sialyltransferases for carbohydrate synthesis Trends in Glycoscience and Glycotechnology  2001 13:345-360
    • Le, V. D., Mak, C. C., Lin, Y. C., Elder, J. H., Wong, C. H. Structure-activity studies of fiv and hiv protease inhibitors containing allophenylnorstatine Bioorganic & Medicinal Chemistry  2001 9:1185-1195  DOI:10.1016/s0968-0896(00)00346-1  PMID:11377177
    • Sears, P., Wong, C. H. Toward automated synthesis of oligosaccharides and glycoproteins Science  2001 291:2344-2350  DOI:10.1126/science.1058899  PMID:11269314
    • Silvestri, M. G., Wong, C. H. Opening of thiiranes: Preparation of orthogonal protected 2-thioglyceraldehyde Journal of Organic Chemistry  2001 66:910-914  DOI:10.1021/jo001392v  PMID:11430112
    • Mak, C. C., Le, V. D., Lin, Y. C., Elder, J. H., Wong, C. H. Design, synthesis, and biological evaluation of hiv/fiv protease inhibitors incorporating a conformationally constrained macrocycle with a small p3 ' residue Bioorganic & Medicinal Chemistry Letters  2001 11:219-222  DOI:10.1016/s0960-894x(00)00641-7  PMID:11206463
    • Ritter, T. K., Wong, C. H. Synthesis of N-acetylglucosamine thiazoline/lipid II hybrids Tetrahedron Letters  2001 42:615-618  DOI:10.1016/s0040-4039(00)02020-7
    • Koeller, K. M., Wong, C. H. Enzymes for chemical synthesis Nature  2001 409:232-240  DOI:10.1038/35051706  PMID:11196651
    • Ritter, T. K., Wong, C. H. Carbohydrate-based antibiotics: a new approach to tackling the problem of resistance Angewandte Chemie-International Edition  2001 40:3508-3533  DOI:10.1002/1521-3773(20011001)40:19<3508::AID-ANIE3508>3.0.CO;2-I  PMID:11592183
    • Ye, X. S., Huang, X. F., Wong, C. H. Conversion of the carboxy group of sialic acid donors to a protected hydroxymethyl group yields an efficient reagent for the synthesis of the unnatural beta-linkage Chemical Communications  2001 974-975  DOI:10.1039/b102166b
    • Burkhart, F., Zhang, Z. Y., Wacowich-Sgarbi, S., Wong, C. H. Synthesis of the globo h hexasaccharide using the programmable reactivity-based one-pot strategy Angewandte Chemie-International Edition  2001 40:1274-1277  DOI:10.1002/1521-3773(20010401)40:7<1274::aid-anie1274>3.0.co;2-w  PMID:11301448
    • Yu, C. S., Niikura, K., Lin, C. C., Wong, C. H. The thioglycoside and glycosyl phosphite of 5-azido sialic acid: Excellent donors for the alpha-glycosylation of primary hydroxy groups Angewandte Chemie-International Edition  2001 40:2900-2903  DOI:10.1002/1521-3773(20010803)40:15<2900::aid-anie2900>3.0.co;2-4  PMID:11500903
    • Tsai, C. Y., Huang, X. F., Wong, C. H. Design and synthesis of cyclic sialyl lewis x mimetics: A remarkable enhancement of inhibition by pre-organizing all essential functional groups Tetrahedron Letters  2000 41:9499-9503  DOI:10.1016/s0040-4039(00)01653-1
    • Romero, A., Wong, C. H. Chemo-enzymatic total synthesis of 3-epiaustraline, australine, and 7-epialexine Journal of Organic Chemistry  2000 65:8264-8268  DOI:10.1021/jo000933d  PMID:11101383
    • Sucheck, S. J., Wong, C. H. Rna as a target for small molecules Current Opinion in Chemical Biology  2000 4:678-686  DOI:10.1016/s1367-5931(00)00142-3  PMID:11102874
    • Koeller, K. M., Wong, C. H. Synthesis of complex carbohydrates and glycoconjugates: Enzyme-based and programmable one-pot strategies Chemical Reviews  2000 100:4465-4493  DOI:10.1021/cr990297n  PMID:11749355
    • Koeller, K. M., Wong, C. H. Complex carbohydrate synthesis tools for glycobiologists: Enzyme-based approach and programmable one-pot strategies Glycobiology  2000 10:1157-1169  DOI:10.1093/glycob/10.11.1157  PMID:11087708
    • Fong, S., Machajewski, T. D., Mak, C. C., Wong, C. H. Directed evolution of d-2-keto-3-deoxy-6-phosphogluconate aldolase to new variants for the efficient synthesis of d- and l-sugars Chemistry & Biology  2000 7:873-883  DOI:10.1016/s1074-5521(00)00035-1  PMID:11094340
    • Flessner, T., Wong, C. H. Efficient synthesis of triazoles from d-arabinose and l-fucose Tetrahedron Letters  2000 41:7805-7808  DOI:10.1016/s0040-4039(00)01356-3
    • Duffels, A., Green, L. G., Lenz, R., Ley, S. V., Vincent, S. P., Wong, C. H. Chemoenzymatic synthesis of l-galactosylated dimeric sialyl lewis x structures employing alpha-1,3-fucosyltransferase v Bioorganic & Medicinal Chemistry  2000 8:2519-2525  DOI:10.1016/s0968-0896(00)00187-5  PMID:11058047
    • Burkart, M. D., Izumi, M., Chapman, E., Lin, C. H., Wong, C. H. Regeneration of PAPS for the enzymatic synthesis of sulfated oligosaccharides Journal of Organic Chemistry  2000 65:5565-5574  DOI:10.1021/jo000266o  PMID:10970295
    • Burkart, M. D., Vincent, S. P., Duffels, A., Murray, B. W., Ley, S. V., Wong, C. H. Chemo-enzymatic synthesis of fluorinated sugar nucleotide: Useful mechanistic probes for glycosyltransferases Bioorganic & Medicinal Chemistry  2000 8:1937-1946  DOI:10.1016/s0968-0896(00)00139-5  PMID:11003139
    • Koeller, K. M., Wong, C. H. Emerging themes in medicinal glycoscience Nature Biotechnology  2000 18:835-841  PMID:10932151
    • Vincent, S. P., Schleyer, A., Wong, C. H. Asymmetric strecker synthesis of c-glycopeptide Journal of Organic Chemistry  2000 65:4440-4443  DOI:10.1021/jo000034p  PMID:10891150
    • Sun, X. L., Kanie, Y., Guo, C. T., Kanie, O., Suzuki, Y., Wong, C. H. Syntheses of c-3-modified sialylglycosides as selective inhibitors of influenza hemagglutinin and neuraminidase European Journal of Organic Chemistry  2000 2643-2653
    • Takayanagi, M., Flessner, T., Wong, C. H. A strategy for the solution-phase parallel synthesis of n-(pyrrolidinylmethyl)hydroxamic acids Journal of Organic Chemistry  2000 65:3811-3815  DOI:10.1021/jo000186k  PMID:10864769
    • Tolbert, T. J., Wong, C. H. Intein-mediated synthesis of proteins containing carbohydrates and other molecular probes Journal of the American Chemical Society  2000 122:5421-5428  DOI:10.1021/ja0000192
    • Sucheck, S. J., Wong, A. L., Koeller, K. M., Boehr, D. D., Draker, K., Sears, P., Wright, G. D., Wong, C. H. Design of bifunctional antibiotics that target bacterial rRNA and inhibit resistance-causing enzymes Journal of the American Chemical Society  2000 122:5230-5231  DOI:10.1021/ja000575w
    • Koeller, K. M., Smith, M. E. B., Huang, R. F., Wong, C. H. Chemoenzymatic synthesis of a PSGL-1 N-terminal glycopeptide containing tyrosine sulfate and α-O-linked sialyl Lewis X Journal of the American Chemical Society  2000 122:4241-4242  DOI:10.1021/ja0004938
    • Lin, Y. C., Beck, Z., Le, V. D., Morris, G. M., Olson, A. J., Wong, C. H., Elder, J. H., Lee, T. Alteration of substrate and inhibitor specificity of feline immunodeficiency virus protease Journal of Virology  2000 74:4710-4720  DOI:10.1128/jvi.74.10.4710-4720.2000  PMID:10775609  PMCID:PMC111993
    • Koeller, K. M., Smith, M. E. B., Wong, C. H. Chemoenzymatic synthesis of PSGL-1 glycopeptides: sulfation on tyrosine affects glycosyltransferase-catalyzed synthesis of the O-glycan Bioorganic & Medicinal Chemistry  2000 8:1017-1025  DOI:10.1016/s0968-0896(00)00041-9  PMID:10882013
    • Ye, X. S., Wong, C. H. Anomeric reactivity-based one-pot oligosaccharide synthesis: A rapid route to oligosaccharide libraries Journal of Organic Chemistry  2000 65:2410-2431  DOI:10.1021/jo991558w  PMID:10789453
    • Shibata, K., Hiruma, K., Kanie, O., Wong, C. H. Synthesis of 1,1-linked galactosyl mannosides carrying a thiazine ring as mimetics of sialyl lewis x antigen: Investigation of the effect of carboxyl group orientation on p-selectin inhibition Journal of Organic Chemistry  2000 65:2393-2398  DOI:10.1021/jo991556b  PMID:10789451
    • Le, V. D., Wong, C. H. Synthesis of 2-substituted polyhydroxytetrahydropyrimidines (n-hydroxy cyclic guanidino-sugars): Transition state mimics of enzymatic glycosidic cleavage Journal of Organic Chemistry  2000 65:2399-2409  DOI:10.1021/jo9915574  PMID:10789452
    • Koeller, K. M., Wong, C. H. Chemoenzymatic synthesis of sialyl-trimeric-Lewis X Chemistry-a European Journal  2000 6:1243-1251  DOI:10.1002/(sici)1521-3765(20000403)6:7<1243::aid-chem1243>3.3.co;2-a  PMID:10785811
    • Nishide, K., Shibata, K., Fujita, T., Kajimoto, T., Wong, C. H., Node, M. An asymmetric total synthesis of a potent immunosuppressant, mycestericins D and F, through an aldol reaction using L-threonine aldolase Heterocycles  2000 52:1191-1201  DOI:10.3987/COM-99-S117
    • Koeller, K. M., Smith, M. E. B., Wong, C. H. Tyrosine sulfation on a psgl-1 glycopeptide influences the reactivity of glycosyltransferases responsible for synthesis of the attached o-glycan Journal of the American Chemical Society  2000 122:742-743  DOI:10.1021/ja993820o
    • Wittmann, V., Datta, A. K., Koeller, K. M., Wong, C. H. Chemoenzymatic synthesis and fluorescent visualization of cell-surface selectin-bound sialyl Lewis X derivatives Chemistry-a European Journal  2000 6:162-171  DOI:10.1002/(sici)1521-3765(20000103)6:1<162::aid-chem162>3.0.co;2-9  PMID:10747401
    • Sucheck, S. J., Greenberg, W. A., Tolbert, T. J., Wong, C. H. Design of small molecules that recognize rna: Development of aminoglycosides as potential antitumor agents that target oncogenic rna sequences Angewandte Chemie-International Edition  2000 39:1080-1084  DOI:10.1002/(sici)1521-3773(20000317)39:6<1080::aid-anie1080>3.0.co;2-b  PMID:10760928
    • Sheppard, T. L., Wong, C. H., Joyce, G. F. Nucleoglycoconjugates: Design and synthesis of a new class of DNA-carbohydrate conjugates Angewandte Chemie-International Edition  2000 39:3660-3663  DOI:10.1002/1521-3773(20001016)39:20<3660::aid-anie3660>3.0.co;2-l  PMID:11091431
    • Kanie, O., Grotenbreg, G., Wong, C. H. Removal of benzyl protecting groups from solid-supported compounds by hydrogenolysis using palladium nanoparticles Angewandte Chemie-International Edition  2000 39:4545-4547  DOI:10.1002/1521-3773(20001215)39:24<4545::aid-anie4545>3.3.co;2-m  PMID:11169665
    • Li, M., Morris, G. M., Lee, T., Laco, G. S., Wong, C. H., Olson, A. J., Elder, J. H., Wlodawer, A., Gustchina, A. Structural studies of FIV and HIV-1 proteases complexed with all efficient inhibitor of FIV protease Proteins-Structure Function and Genetics  2000 38:29-40  DOI:10.1002/(sici)1097-0134(20000101)38:1<29::aid-prot4>3.0.co;2-n  PMID:10651036
    • Machajewski, T. D., Wong, C. H. The catalytic asymmetric aldol reaction Angewandte Chemie-International Edition  2000 39:1352-1374  DOI:10.1002/(sici)1521-3773(20000417)39:8<1352::aid-anie1352>3.0.co;2-j  PMID:10777624
    • Shen, G. J., Datta, A. K., Izumi, M., Koeller, K. M., Wong, C. H. Expression of α2,8/2,9-polysialyltransferase from escherichia coli K92 - characterization of the enzyme and its reaction products Journal of Biological Chemistry  1999 274:35139-35146  DOI:10.1074/jbc.274.49.35139  PMID:10574996
    • Depre, D., Duffels, A., Green, L. G., Lenz, R., Ley, S. V., Wong, C. H. Synthesis of glycans from the glycodelins: Two undeca-, two deca-, three nona-, an octa- and a heptasaccharide Chemistry-a European Journal  1999 5:3326-3340  DOI:10.1002/(sici)1521-3765(19991105)5:11<3326::aid-chem3326>3.0.co;2-q
    • Burkart, M. D., Wong, C. H. A continuous assay for the spectrophotometric analysis of sulfotransferases using aryl sulfotransferase iv Analytical Biochemistry  1999 274:131-137  DOI:10.1006/abio.1999.4264  PMID:10527506
    • Koeller, K. M., Wong, C. H. Synthesis of biologically active glycopeptides Journal of the Chinese Chemical Society  1999 46:659-685
    • Hiranuma, S., Kanie, O., Wong, C. H. Formation of the 1,2,6-orthoester of mannose and its utilization in the glycosylation reaction Tetrahedron Letters  1999 40:6423-6426  DOI:10.1016/s0040-4039(99)01193-4
    • Burkart, M. D., Vincent, S. P., Wong, C. H. An efficient synthesis of cmp-3-fluoroneuraminic acid Chemical Communications  1999 1525-1526  DOI:10.1039/a903362i
    • Weitz-Schmidt, G., Gong, K. W., Wong, C. H. Selectin/glycoconjugate binding assays for the identification and optimization of selectin antagonists Analytical Biochemistry  1999 273:81-88  DOI:10.1006/abio.1999.4180  PMID:10452802
    • Greenberg, W. A., Priestley, E. S., Sears, P. S., Alper, P. B., Rosenbohm, C., Hendrix, M., Hung, S. C., Wong, C. H. Design and synthesis of new aminoglycoside antibiotics containing neamine as an optimal core structure: Correlation of antibiotic activity with in vitro inhibition of translation Journal of the American Chemical Society  1999 121:6527-6541  DOI:10.1021/ja9910356
    • Takebayashi, M., Hiranuma, S., Kanie, Y., Kajimoto, T., Kanie, O., Wong, C. H. A versatile synthetic strategy for the preparation and discovery of new iminocyclitols as inhibitors of glycosidases Journal of Organic Chemistry  1999 64:5280-5291  DOI:10.1021/jo9902446
    • Vincent, S. P., Burkart, M. D., Tsai, C. Y., Zhang, Z. Y., Wong, C. H. Electrophilic fluorination-nucleophilic addition reaction mediated by selectfluor: Mechanistic studies and new applications Journal of Organic Chemistry  1999 64:5264-5279  DOI:10.1021/jo990686h
    • Mao, S. L., Gao, C., Lo, C. H. L., Wirsching, P., Wong, C. H., Janda, K. D. Phage-display library selection of high-affinity human single-chain antibodies to tumor-associated carbohydrate antigens sialyl Lewis(x) and Lewis(x) Proceedings of the National Academy of Sciences of the United States of America  1999 96:6953-6958  DOI:10.1073/pnas.96.12.6953  PMID:10359820
    • Wong, C. H. Design and synthesis of carbohydrate mimetics: A new strategy for tackling the problem of carbohydrate-mediated biological recognition Journal of the Chinese Chemical Society  1999 46:271-281
    • Huwe, C. M., Woltering, T. J., Jiricek, J., Weitz-Schmidt, G., Wong, C. H. Design, synthesis and biological evaluation of aryl-substituted sialyl lewis x mimetics prepared via cross-metathesis of c-fucopeptides Bioorganic & Medicinal Chemistry  1999 7:773-788  DOI:10.1016/s0968-0896(98)00245-4  PMID:10400330
    • Zhang, X. D., Rosenthal, P. B., Formanowski, F., Fitz, W., Wong, C. H., Meier-Ewert, H., Skehel, J. J., Wiley, D. C. X-ray crystallographic determination of the structure of the influenza c virus haemagglutinin-esterase-fusion glycoprotein Acta Crystallographica Section D-Biological Crystallography  1999 55:945-961  DOI:10.1107/s0907444999000232  PMID:10216291
    • Wong, C. H. Mimics of complex carbohydrates recognized by receptors Accounts of Chemical Research  1999 32:376-385  DOI:10.1021/ar960237t
    • Wu, W. G., Pasternack, L., Huang, D. H., Koeller, K. M., Lin, C. C., Seitz, O., Wong, C. H. Structural study on O-glycopeptides: Glycosylation-induced conformational changes of O-GlcNAc, O-LacNAc, O-Sialyl-LacNAc, and O-Sialyl-Lewis-X peptides of the mucin domain of madcam-1 Journal of the American Chemical Society  1999 121:2409-2417  DOI:10.1021/ja983474v
    • Sears, P., Witte, K., Wong, C. H. The effect of counterion, water concentration, and stirring on the stability of subtilisin BPN′ in organic solvents Journal of Molecular Catalysis B-Enzymatic  1999 6:297-304  DOI:10.1016/s1381-1177(98)00085-x
    • Lin, C. C., Moris-Varas, F., Weitz-Schmidt, G., Wong, C. H. Synthesis of sialyl Lewis x mimetics as selectin inhibitors by enzymatic aldol condensation reactions Bioorganic & Medicinal Chemistry  1999 7:425-433  DOI:10.1016/s0968-0896(98)00242-9  PMID:10220028
    • Yuasa, H., Hashimoto, H., Abe, Y., Kajimoto, T., Wong, C. H. Studies on the unusual stability of cis-2,5-diethoxy-2,5-bis(hydroxymethyl)-1,4-dioxane Tetrahedron  1999 55:2193-2204  DOI:10.1016/s0040-4020(99)00003-4
    • Lee, T. Y., Le, V. D., Lim, D. Y., Lin, Y. C., Morris, G. M., Wong, A. L., Olson, A. J., Elder, J. H., Wong, C. H. Development of a new type of protease inhibitors, efficacious against FIV and HIV variants Journal of the American Chemical Society  1999 121:1145-1155  DOI:10.1021/ja982893p
    • Zhang, Z. Y., Ollmann, I. R., Ye, X. S., Wischnat, R., Baasov, T., Wong, C. H. Programmable one-pot oligosaccharide synthesis Journal of the American Chemical Society  1999 121:734-753  DOI:10.1021/ja982232s
    • Kidd, R. D., Sears, P., Huang, D. H., Witte, K., Wong, C. H., Farber, G. K. Breaking the low barrier hydrogen bond in a serine protease Protein Science  1999 8:410-417  DOI:10.1110/ps.8.2.410  PMID:10048334  PMCID:PMC2144249
    • Takayama, S., Chung, S. J., Igarashi, Y., Ichikawa, Y., Sepp, A., Lechler, R. I., Wu, J., Hayashi, T., Siuzdak, G., Wong, C. H. Selective inhibition of β-1,4- and α-1,3-galactosyltransferases: donor sugar-nucleotide based approach Bioorganic & Medicinal Chemistry  1999 7:401-409  DOI:10.1016/s0968-0896(98)00249-1  PMID:10218835
    • Takayama, S., Lee, S. T., Hung, S. C., Wong, C. H. Designing enzymatic resolution of amines Chemical Communications  1999 127-128  DOI:10.1039/a808028c
    • Sears, P., Wong, C. H. Carbohydrate mimetics: a new strategy for tackling the problem of carbohydrate-mediated biological recognition Angewandte Chemie-International Edition  1999 38:2300-2324  DOI:10.1002/(SICI)1521-3773(19990816)38:16<2300::AID-ANIE2300>3.0.CO;2-6  PMID:10458780
    • Machajewski, T. D., Wong, C. H. Chemoenzymatic synthesis of key epothilone fragments Synthesis-Stuttgart  1999 1469-1472
    • Burkart, M. D., Izumi, M., Wong, C. H. Enzymatic regeneration of 3 '-phosphoadenosine-5 '-phosphosulfate using aryl sulfotransferase for the preparative enzymatic synthesis of sulfated carbohydrates Angewandte Chemie-International Edition  1999 38:2747-2750  DOI:10.1002/(sici)1521-3773(19990917)38:18<2747::aid-anie2747>3.0.co;2-2  PMID:10508369
    • Hiruma, K., Kanie, O., Wong, C. H. Synthesis of analogs of 1,1-linked galactosyl mannoside as mimetics of sialyl lewis x tetrasaccharide Tetrahedron  1998 54:15781-15792  DOI:10.1016/s0040-4020(98)00990-9
    • Witte, K., Skolnick, J., Wong, C. H. A synthetic retrotransition (backward reading) sequence of the right-handed three-helix bundle domain (10-53) of protein a shows similarity in conformation as predicted by computation Journal of the American Chemical Society  1998 120:13042-13045  DOI:10.1021/ja982203h
    • Chung, S. J., Takayama, S., Wong, C. H. Acceptor substrate-based selective inhibition of galactosyltransferases Bioorganic & Medicinal Chemistry Letters  1998 8:3359-3364  DOI:10.1016/s0960-894x(98)00618-0  PMID:9873734
    • Wischnat, R., Martin, R., Takayama, S., Wong, C. H. Chemoenzymatic synthesis of iminocyclitol derivatives: A useful library strategy for the development of selective fucosyltransfer enzymes inhibitors Bioorganic & Medicinal Chemistry Letters  1998 8:3353-3358  DOI:10.1016/s0960-894x(98)00617-9  PMID:9873733
    • Simanek, E. E., Huang, D. H., Pasternack, L., Machajewski, T. D., Seitz, O., Millar, D. S., Dyson, H. J., Wong, C. H. Glycosylation of threonine of the repeating unit of RNA polymerase II with beta-linked N-acetylglucosame leads to a turnlike structure Journal of the American Chemical Society  1998 120:11567-11575  DOI:10.1021/ja982312w
    • Wischnat, R., Martin, R., Wong, C. H. Synthesis of a new class of n-linked lewis and lacnac analogues as potential inhibitors of human fucosyltransferases: A general method for the incorporation of an iminocyclitol as a transition-state mimetic of the donor sugar to the acceptor Journal of Organic Chemistry  1998 63:8361-8365  DOI:10.1021/jo981245l
    • Rosenthal, P. B., Zhang, X. D., Formanowski, F., Fitz, W., Wong, C. H., Meier-Ewert, H., Skehel, J. J., Wiley, D. C. Structure of the haemagglutinin-esterase-fusion glycoprotein of influenza c virus Nature  1998 396:92-96  PMID:9817207
    • Guo, C. T., Wong, C. H., Kajimoto, T., Miura, T., Ida, Y., Juneja, L. R., Kim, M. J., Masuda, H., Suzuki, T., Suzuki, Y. Synthetic sialylphosphatidylethanolamine derivatives bind to human influenza a viruses and inhibit viral infection Glycoconjugate Journal  1998 15:1099-1108  DOI:10.1023/a:1006961912465  PMID:10386895
    • Kanie, Y., Kirsch, A., Kanie, O., Wong, C. H. Enzymatic assay of galactosyltransferase by capillary electrophoresis Analytical Biochemistry  1998 263:240-245  DOI:10.1006/abio.1998.2762  PMID:9799537
    • Tsai, C. Y., Park, W. K. C., Weitz-Schmidt, G., Ernst, B., Wong, C. H. Synthesis of sialyl lewis x mimetics using the ugi four-component reaction Bioorganic & Medicinal Chemistry Letters  1998 8:2333-2338  DOI:10.1016/s0960-894x(98)00422-3  PMID:9873537
    • Vassilev, V. P., Simanek, E. E., Wood, M. R., Wong, C. H. Enzymatic synthesis of a chiral gelator with remarkably low molecular weight Chemical Communications  1998 1865-1866  DOI:10.1039/a803230k
    • Hogg, J. H., Ollmann, I. R., Wetterholm, A., Andberg, M. B., Haeggstrom, J., Samuelsson, B., Wong, C. H. Probing the activities and mechanisms of leukotriene a(4) hydrolase with synthetic inhibitors Chemistry-a European Journal  1998 4:1698-1713  DOI:10.1002/(sici)1521-3765(19980904)4:9<1698::aid-chem1698>3.3.co;2-a
    • Miura, T., Kajimoto, T., Jimbo, M., Yamagishi, K., Inokuchi, J. C., Wong, C. H. Synthesis and evaluation of morpholino- and pyrrolidinosphingolipids as inhibitors of glucosylceramide synthase Bioorganic & Medicinal Chemistry  1998 6:1481-1489  DOI:10.1016/s0968-0896(98)00077-7  PMID:9801819
    • Wong, C. H.*, Hendrix, M.*, Manning, D. D., Rosenbohm, C., Greenberg, W. A. A library approach to the discovery of small molecules that recognize rna: Use of a 1,3-hydroxyamine motif as core Journal of the American Chemical Society  1998 120:8319-8327  DOI:10.1021/ja980826p (* = equal contribution)
    • Martin, R., Witte, K. L., Wong, C. H. The synthesis and enzymatic incorporation of sialic acid derivatives for use as tools to study the structure, activity, and inhibition of glycoproteins and other glycoconjugates Bioorganic & Medicinal Chemistry  1998 6:1283-1292  DOI:10.1016/s0968-0896(98)00121-7  PMID:9784869
    • Wittmann, V., Takayama, S., Gong, K. W., Weitz-Schmidt, G., Wong, C. H. Ligand recognition by E- and P-selectin: Chemoenzymatic synthesis and inhibitory activity of bivalent sialyl Lewis x derivatives and sialyl Lewis x carboxylic acids Journal of Organic Chemistry  1998 63:5137-5143  DOI:10.1021/jo980350s
    • Wong, C. H., Ye, X. S., Zhang, Z. Y. Assembly of oligosaccharide libraries with a designed building block and an efficient orthogonal protection-deprotection strategy Journal of the American Chemical Society  1998 120:7137-7138  DOI:10.1021/ja9813616
    • Lampe, T. F. J., Weitz-Schmidt, G., Wong, C. H. Parallel synthesis of sialyl lewis x mimetics on a solid phase: Access to a library of fucopeptides Angewandte Chemie-International Edition  1998 37:1707-1711  DOI:10.1002/(sici)1521-3773(19980703)37:12<1707::aid-anie1707>3.3.co;2-m
    • Wong, C. H.*, Hendrix, M.*, Priestley, E. S., Greenberg, W. A. Specificity of aminoglycoside antibiotics for the a-site of the decoding region of ribosomal rna Chemistry & Biology  1998 5:397-406  DOI:10.1016/s1074-5521(98)90073-4  PMID:9662506 (* = equal contribution)
    • Kamitakahara, H., Suzuki, T., Nishigori, N., Suzuki, Y., Kanie, O., Wong, C. H. A lysoganglioside poly-l-glutamic acid conjugate as a picomolar inhibitor of influenza hemagglutinin Angewandte Chemie-International Edition  1998 37:1524-1528  DOI:10.1002/(sici)1521-3773(19980619)37:11<1524::aid-anie1524>3.3.co;2-4
    • Sears, P., Wong, C. H. Mechanism-based inhibition of carbohydrate-mediated biological recognitions Chemical Communications  1998 1161-1170  DOI:10.1039/a800838h
    • Anderson, C. M., Mandell, A. J., Selz, K. A., Terry, L. M., Wong, C. H., Robinson, S. R., Robertson, S. S., Smotherman, W. P. The development of nuchal atonia associated with active (rem) sleep in fetal sheep: Presence of recurrent fractal organization Brain Research  1998 787:351-357  DOI:10.1016/s0006-8993(98)00008-0  PMID:9518691
    • Alper, P. B., Hendrix, M., Sears, P., Wong, C. H. Probing the specificity of aminoglycoside ribosomal rna interactions with designed synthetic analogs Journal of the American Chemical Society  1998 120:1965-1978  DOI:10.1021/ja972599h
    • Witte, K., Seitz, O., Wong, C. H. Solution- and solid-phase synthesis of n-protected glycopeptide esters of the benzyl type as substrates for subtilisin-catalyzed glycopeptide couplings Journal of the American Chemical Society  1998 120:1979-1989  DOI:10.1021/ja9736727
    • Sears, P., Wong, C. H. Enzyme action in glycoprotein synthesis Cellular and Molecular Life Sciences  1998 54:223-252  DOI:10.1007/s000180050146  PMID:9575336
    • Simanek, E. E., McGarvey, G. J., Jablonowski, J. A., Wong, C. H. Selectin-carbohydrate interactions: From natural ligands to designed mimics Chemical Reviews  1998 98:833-862  DOI:10.1021/cr940226i  PMID:11848916
    • Lee, T., Laco, G. S., Torbett, B. E., Fox, H. S., Lerner, D. L., Elder, J. H., Wong, C. H. Analysis of the S3 and S3' subsite specificities of feline immunodeficiency virus (FIV) protease: development of a broad-based protease inhibitor efficacious against FIV, SIV, and HIV in vitro and ex vivo Proceedings of the National Academy of Sciences of the United States of America  1998 95:939-944  DOI:10.1073/pnas.95.3.939  PMID:9448264  PMCID:PMC18632
    • Kanemitsu, T., Kanie, O., Wong, C. H. Quantitative monitoring of solid-phase synthesis using gated decoupling c-13 NMR spectroscopy with a c-13-enriched protecting group and an internal standard in the synthesis of sialyl lewis(x) tetrasaccharide Angewandte Chemie-International Edition  1998 37:3415-3418  DOI:10.1002/(sici)1521-3773(19981231)37:24<3415::aid-anie3415>3.0.co;2-8
    • Burkart, M. D., Zhang, Z. Y., Hung, S. C., Wong, C. H. A new method for the synthesis of fluoro-carbohydrates and glycosides using selectfluor Journal of the American Chemical Society  1997 119:11743-11746  DOI:10.1021/ja9723904
    • Kimura, T., Vassilev, V. P., Shen, G. J., Wong, C. H. Enzymatic synthesis of beta-hydroxy-alpha-amino acids based on recombinant d- and l-threonine aldolases Journal of the American Chemical Society  1997 119:11734-11742  DOI:10.1021/ja9720422
    • Takayama, S., McGarvey, G. J., Wong, C. H. Enzymes in organic synthesis: Recent developments in aldol reactions and glycosylations Chemical Society Reviews  1997 26:407-415  DOI:10.1039/cs9972600407
    • Kaneko, M., Kanie, O., Kajimoto, T., Wong, C. H. Toward a transition state analog inhibitor of n-acetylglucosaminyl transferase v Bioorganic & Medicinal Chemistry Letters  1997 7:2809-2812  DOI:10.1016/s0960-894x(97)10087-7
    • Koketsu, M., Nitoda, T., Sugino, H., Juneja, L. R., Kim, M., Yamamoto, T., Abe, N., Kajimoto, T., Wong, C. H. Synthesis of a novel sialic acid derivative (sialylphospholipid) as an antirotaviral agent Journal of Medicinal Chemistry  1997 40:3332-3335  DOI:10.1021/jm9701280  PMID:9341907
    • Ikeda, T., Kajimoto, T., Kondo, H., Wong, C. H. Design and synthesis of an alpha-mannosyl terpenoid as selective inhibitor of p-selectin Bioorganic & Medicinal Chemistry Letters  1997 7:2485-2490  DOI:10.1016/s0960-894x(97)10022-1
    • Seitz, O., Wong, C. H. Chemoenzymatic solution- and solid-phase synthesis of o-glycopeptides of the mucin domain of madcam-1. A general route to o-lacnac, o-sialyl-lacnac, and o-sialyl-lewis-x peptides Journal of the American Chemical Society  1997 119:8766-8776  DOI:10.1021/ja971383c
    • Takayama, S., Martin, R., Wu, J., Laslo, K., Siuzdak, G., Wong, C. H. Chemoenzymatic preparation of novel cyclic imine sugars and rapid biological activity evaluation using electrospray mass spectrometry and kinetic analysis Journal of the American Chemical Society  1997 119:8146-8151  DOI:10.1021/ja971695f
    • Wong, C. H., MorisVara, F., Hung, S. C., Marron, T. G., Lin, C. C., Gong, K. W., WeitzSchmidt, G. Small molecules as structural and functional mimics of sialyl Lewis X tetrasaccharide in selectin inhibition: A remarkable enhancement of inhibition by additional negative charge and/or hydrophobic group Journal of the American Chemical Society  1997 119:8152-8158  DOI:10.1021/ja970920q
    • Wu, J., Takayama, S., Wong, C. H., Siuzdak, G. Quantitative electrospray mass spectrometry for the rapid assay of enzyme inhibitors Chemistry & Biology  1997 4:653-657  DOI:10.1016/s1074-5521(97)90220-9  PMID:9331404
    • Hung, S. C., Lin, C. C., Wong, C. H. One-pot synthesis of 1-allyl- and 1-allenyl-6-O-acetyl-2,3,4-tri-O-benzyl-α-D-glycosides from methyl tetra-O-benzyl-α-D-glycosides Tetrahedron Letters  1997 38:5419-5422  DOI:10.1016/s0040-4039(97)01204-5
    • Takayama, S., Wong, C. H. Chemo-enzymatic approach to carbohydrate recognition Current Organic Chemistry  1997 1:109-126
    • McGarvey, G. J., Wong, C. H. Chemical, enzymatic and structural studies in molecular glycobiology Liebigs Annalen-Recueil  1997 1059-1074
    • Kim, M. J., Lim, I. T., Kim, H. J., Wong, C. H. Enzymatic single aldol reactions of remote dialdehydes Tetrahedron-Asymmetry  1997 8:1507-1509  DOI:10.1016/s0957-4166(97)00139-0
    • Moree, W. J., Sears, P., Kawashiro, K., Witte, K., Wong, C. H. Exploitation of subtilisin bpn' as catalyst for the synthesis of peptides containing noncoded amino acids, peptide mimetics and peptide conjugates Journal of the American Chemical Society  1997 119:3942-3947  DOI:10.1021/ja964399w
    • Hendrix, M., Priestley, E. S., Joyce, G. F., Wong, C. H. Direct observation of aminoglycoside-RNA interactions by surface plasmon resonance Journal of the American Chemical Society  1997 119:3641-3648  DOI:10.1021/ja964290o  PMID:11540136
    • Lin, C. C., Lin, C. H., Wong, C. H. Sialic acid aldolase-catalyzed condensation of pyruvate and N-substituted mannosamine: A useful method for the synthesis of N-substituted sialic acids Tetrahedron Letters  1997 38:2649-2652  DOI:10.1016/s0040-4039(97)00442-5
    • Wittmann, V., Wong, C. H. 1H-tetrazole as catalyst in phosphomorpholidate coupling reactions: efficient synthesis of GDP-fucose, GDP-mannose, and UDP-galactose Journal of Organic Chemistry  1997 62:2144-2147  DOI:10.1021/jo9620066  PMID:11671520
    • Wang, R., Steensma, D. H., Takaoka, Y., Yun, J. W., Kajimoto, T., Wong, C. H. A search for pyrophosphate mimics for the development of substrates and inhibitors of glycosyltransferases Bioorganic & Medicinal Chemistry  1997 5:661-672  DOI:10.1016/s0968-0896(97)00005-9  PMID:9158864
    • Witte, K., Sears, P., Martin, R., Wong, C. H. Enzymatic glycoprotein synthesis: Preparation of ribonuclease glycoforms via enzymatic glycopeptide condensation and glycosylation Journal of the American Chemical Society  1997 119:2114-2118  DOI:10.1021/ja961846z
    • Wong, C. H. A chemo-enzymatic approach to the study of carbohydrate-based biological recognitions Pure and Applied Chemistry  1997 69:419-422  DOI:10.1351/pac199769030419
    • Hayashi, T., Murray, B. W., Wang, R., Wong, C. H. A chemoenzymatic synthesis of UDP-(2-deoxy-2-fluoro)-galactose and evaluation of its interaction with galactosyltransferase Bioorganic & Medicinal Chemistry  1997 5:497-500  DOI:10.1016/s0968-0896(96)00263-5  PMID:9113327
    • Janda, K. D., Lo, L. C., Lo, C. H. L., Sim, M. M., Wang, R., Wong, C. H., Lerner, R. A. Chemical selection for catalysis in combinatorial antibody libraries Science  1997 275:945-948  DOI:10.1126/science.275.5302.945  PMID:9020070
    • Murray, B. W., Wittmann, V., Burkart, M. D., Hung, S. C., Wong, C. H. Mechanism of human alpha-1,3-fucosyltransferase v: Glycosidic cleavage occurs prior to nucleophilic attack Biochemistry  1997 36:823-831  DOI:10.1021/bi962284z  PMID:9020780
    • Lin, C. H., Murray, B. W., Ollmann, I. R., Wong, C. H. Why is CMP-ketodeoxyoctonate highly unstable? Biochemistry  1997 36:780-785  DOI:10.1021/bi962055c  PMID:9020775
    • Hendrix, M., Alper, P. B., Priestley, E. S., Wong, C. H. Hydroxyamines as a new motif for the molecular recognition of phosphodiesters: Implications for aminoglycoside-rna interactions Angewandte Chemie-International Edition  1997 36:95-98  DOI:10.1002/anie.199700951
    • Takayama, S., McGarvey, G. J., Wong, C. H. Microbial aldolases and transketolases: New biocatalytic approaches to simple and complex sugars Annual Review of Microbiology  1997 51:285-310  DOI:10.1146/annurev.micro.51.1.285  PMID:9343352
    • Cappi, M. W., Moree, W. J., Qiao, L., Marron, T. G., WeitzSchmidt, G., Wong, C. H. Synthesis of novel 6-amido-6-deoxy-l-galactose derivatives as sialyl lewis x mimetics Bioorganic & Medicinal Chemistry  1997 5:283-296  DOI:10.1016/s0968-0896(96)00236-2  PMID:9061193
    • Takayama, S., Livingston, P. O., Wong, C. H. Synthesis of the melanoma-associated ganglioside 9-O-acetyl GD3 through regioselective enzymatic acetylation of GD3 using subtilisin Tetrahedron Letters  1996 37:9271-9274  DOI:10.1016/s0040-4039(97)82939-5
    • Woltering, T. J., WeitzSchmidt, G., Wong, C. H. C-fucopeptides as selectin antagonists: Attachment of lipid moieties enhances the activity Tetrahedron Letters  1996 37:9033-9036  DOI:10.1016/s0040-4039(96)02121-1
    • Marron, T. G., Woltering, T. J., WeitzSchmidt, G., Wong, C. H. C-mannose derivatives as potent mimics of sialyl lewis x Tetrahedron Letters  1996 37:9037-9040  DOI:10.1016/s0040-4039(96)02124-7
    • Qian, X. H., MorisVaras, F., Fitzgerald, M. C., Wong, C. H. C-2-symmetrical tetrahydroxyazepanes as inhibitors of glycosidases and hiv/fiv proteases Bioorganic & Medicinal Chemistry  1996 4:2055-2069  DOI:10.1016/s0968-0896(96)00218-0  PMID:9022971
    • Lin, C. C., Kimura, T., Wu, S. H., WeitzSchmidt, G., Wong, C. H. Liposome-like fucopeptides as sialyl Lewis X mimetics Bioorganic & Medicinal Chemistry Letters  1996 6:2755-2760  DOI:10.1016/s0960-894x(96)00509-4
    • Hendrix, M., Wong, C. H. A chemoenzymatic approach to carbohydrate-mediated cell adhesion Pure and Applied Chemistry  1996 68:2081-2087  DOI:10.1351/pac199668112081
    • Sears, P., Wong, C. H. Intervention of carbohydrate recognition by proteins and nucleic acids Proceedings of the National Academy of Sciences of the United States of America  1996 93:12086-12093  DOI:10.1073/pnas.93.22.12086  PMID:8901537
    • Park, W. K. C., Auer, M., Jaksche, H., Wong, C. H. Rapid combinatorial synthesis of aminoglycoside antibiotic mimetics: Use of a polyethylene glycol-linked amine and a neamine-derived aldehyde in multiple component condensation as a strategy for the discovery of new inhibitors of the hiv rna rev responsive element Journal of the American Chemical Society  1996 118:10150-10155  DOI:10.1021/ja9612817
    • Hiruma, K., Kajimoto, T., WeitzSchmidt, G., Ollmann, I., Wong, C. H. Rational design and synthesis of a 1,1-linked disaccharide that is 5 times as active as sialyl lewis x in binding to e-selectin Journal of the American Chemical Society  1996 118:9265-9270  DOI:10.1021/ja9611093
    • Murray, B. W., Takayama, S., Schultz, J., Wong, C. H. Mechanism and specificity of human α-1,3-fucosyltransferase V Biochemistry  1996 35:11183-11195  DOI:10.1021/bi961065a  PMID:8780523
    • Takayama, S., Moree, W. J., Wong, C. H. Enzymatic resolution of amines and amino alcohols using pent-4-enoyl derivatives Tetrahedron Letters  1996 37:6287-6290  DOI:10.1016/0040-4039(96)01378-0
    • MorisVaras, F., Qian, X. H., Wong, C. H. Enzymatic/chemical synthesis and biological evaluation of seven-membered iminocyclitols Journal of the American Chemical Society  1996 118:7647-7652  DOI:10.1021/ja960975c
    • Qiao, L., Murray, B. W., Shimazaki, M., Schultz, J., Wong, C. H. Synergistic inhibition of human alpha-1,3-fucosyltransferase v Journal of the American Chemical Society  1996 118:7653-7662  DOI:10.1021/ja960274f
    • Alper, P. B., Hung, S. C., Wong, C. H. Metal catalyzed diazo transfer for the synthesis of azides from amines Tetrahedron Letters  1996 37:6029-6032  DOI:10.1016/0040-4039(96)01307-x
    • Fitz, W., Rosenthal, P. B., Wong, C. H. Synthesis and inhibitory properties of a thiomethylmercuric sialic acid with application to the x-ray structure determination of 9-o-acetylsialic acid esterase from influenza c virus Bioorganic & Medicinal Chemistry  1996 4:1349-1353  DOI:10.1016/0968-0896(96)00123-x  PMID:8879557
    • Wang, R., Wong, C. H. Synthesis of sialyl Lewis X mimetics: Use of O-α-fucosyl-(1R, 2R)-2-aminocyclohexanol as core structure Tetrahedron Letters  1996 37:5427-5430  DOI:10.1016/0040-4039(96)01114-8
    • Lin, C. C., Shimazaki, M., Heck, M. P., Aoki, S., Wang, R., Kimura, T., Ritzen, H., Takayama, S., Wu, S. H., WeitzSchmidt, G., Wong, C. H. Synthesis of sialyl Lewis X mimetics and related structures using the glycosyl phosphite methodology and evaluation of E-selectin inhibition Journal of the American Chemical Society  1996 118:6826-6840  DOI:10.1021/ja952265x
    • Hung, S. C., Wong, C. H. Synthesis of glycosyl chlorides with acid-labile protecting groups Tetrahedron Letters  1996 37:4903-4906  DOI:10.1016/0040-4039(96)01006-4
    • Uchiyama, T., Woltering, T. J., Wong, W. C., Lin, C. C., Kajimoto, T., Takebayashi, M., WeitzSchmidt, G., Asakura, T., Noda, M., Wong, C. H. Design and synthesis of C-linked fucosides as inhibitors of E-selectin Bioorganic & Medicinal Chemistry  1996 4:1149-1165  DOI:10.1016/0968-0896(96)00127-7  PMID:8831987
    • Sears, P., Wong, C. H. Engineering enzymes for bioorganic synthesis: Peptide bond formation Biotechnology Progress  1996 12:423-433  DOI:10.1021/bp9500730
    • Patterson, J. E., Ollmann, I. R., Cravatt, B. F., Boger, D. L., Wong, C. H., Lerner, R. A. Inhibition of oleamide hydrolase catalyzed hydrolysis of the endogenous sleep-inducing lipid cis-9-octadecenamide Journal of the American Chemical Society  1996 118:5938-5945  DOI:10.1021/ja954064z
    • Qian, X. H., MorisVaras, F., Wong, C. H. Synthesis of c-2-symmetrical polyhydroxyazepanes as inhibitors of glycosidases Bioorganic & Medicinal Chemistry Letters  1996 6:1117-1122
    • Takayama, S., Shimazaki, M., Qiao, L., Wong, C. H. Synthesis of lactosamine derivatives using beta-d-galactosidase from bacillus circulans Bioorganic & Medicinal Chemistry Letters  1996 6:1123-1126  DOI:10.1016/0960-894x(96)00184-9
    • Jeong, J. H., Murray, B. W., Takayama, S., Wong, C. H. Cyclic guanidino-sugars with low pKa as transition-state analog inhibitors of glycosidases: Neutral instead of charged species are the active forms Journal of the American Chemical Society  1996 118:4227-4234  DOI:10.1021/ja951602z
    • Shibata, K., Shingu, K., Vassilev, V. P., Nishide, K., Fujita, T., Node, M., Kajimoto, T., Wong, C. H. Kinetic and thermodynamic control of l-threonine aldolase catalyzed reaction and its application to the synthesis of mycestericin d Tetrahedron Letters  1996 37:2791-2794  DOI:10.1016/0040-4039(96)00430-3
    • Wong, C. H. Chemoenzymatic synthesis: Application to the study of carbohydrate recognition Acta Chemica Scandinavica  1996 50:211-218  DOI:10.3891/acta.chem.scand.50-0211  PMID:8901174
    • Kidd, R. D., Yennawar, H. P., Sears, P., Wong, C. H., Farber, G. K. A weak calcium binding site in subtilisin BPN' has a dramatic effect on protein stability Journal of the American Chemical Society  1996 118:1645-1650  DOI:10.1021/ja953443p
    • Orsat, B., Alper, P. B., Moree, W., Mak, C. P., Wong, C. H. Homocarbonates as substrates for the enantioselective enzymatic protection of amines Journal of the American Chemical Society  1996 118:712-713  DOI:10.1021/ja9533048
    • Hendrix, M., Wong, C. H. A chemo-enzymatic approach to the study of carbohydrate recognition in biological systems Enantiomer  1996 1:305-310  PMID:9676274
    • Kimura, T., Takayama, S., Huang, H. M., Wong, C. H. A practical method for the synthesis of N-acetyl-D-lactosamine derivatives by the tandem use of galactose oxidase and β-galactosidase Angewandte Chemie-International Edition  1996 35:2348-2350  DOI:10.1002/anie.199623481
    • DeLuca, C., Lansing, M., Crescenzi, F., Martini, I., Shen, G. J., Oregan, M., Wong, C. H. Overexpression, one-step purification and characterization of udp-glucose dehydrogenase and udp-n-acetylglucosamine pyrophosphorylase Bioorganic & Medicinal Chemistry  1996 4:131-141  DOI:10.1016/0968-0896(95)00159-x  PMID:8689233
    • Gijsen, H. J. M., Qiao, L., Fitz, W., Wong, C. H. Recent advances in the chemoenzymatic synthesis of carbohydrates and carbohydrate mimetics Chemical Reviews  1996 96:443-473  DOI:10.1021/cr950031q  PMID:11848760
    • Hung, S. C., Wong, C. H. Samarium diiodide mediated coupling of glycosyl phosphates with carbon radical or anion acceptors - synthesis of c-glycosides Angewandte Chemie-International Edition  1996 35:2671-2674  DOI:10.1002/anie.199626711
    • Wu, S. H., Shimazaki, M., Lin, C. C., Qiao, L., Moree, W. J., WeitzSchmidt, G., Wong, C. H. Synthesis of fucopeptides as sialyl lewis X mimetics Angewandte Chemie-International Edition  1996 35:88-90  DOI:10.1002/anie.199600881
    • Cappi, M. W., Moree, W. J., Qiao, L., Marron, T. G., WeitzSchmidt, G., Wong, C. H. The synthesis of novel 6-amido-6-deoxy-l-galactose derivatives as potent sialyl lewis(x) mimetics Angewandte Chemie-International Edition  1996 35:2346-2348  DOI:10.1002/anie.199623461
    • Slee, D. H., Laslo, K. L., Elder, J. H., Ollmann, I. R., Gustchina, A., Kervinen, J., Zdanov, A., Wlodawer, A., Wong, C. H. Selectivity in the inhibition of HIV and FIV protease - inhibitory and mechanistic studies of pyrrolidine-containing alpha-keto amide and hydroxyethylamine core structures Journal of the American Chemical Society  1995 117:11867-11878  DOI:10.1021/ja00153a008
    • Lin, C. H., Shimazaki, M., Wong, C. H., Koketsu, M., Juneja, L. R., Kim, M. Enzymatic synthesis of a sialyl Lewis X dimer from egg yolk as an inhibitor of E-selectin Bioorganic & Medicinal Chemistry  1995 3:1625-1630  DOI:10.1016/0968-0896(95)00150-6  PMID:8770386
    • Hiranuma, S., Shimizu, T., Nakata, T., Kajimoto, T., Wong, C. H. Synthesis and inhibition analysis of 5-membered homoazasugars from d-arabinofuranose via an sn2 reaction of the chloromethylsulfonate Tetrahedron Letters  1995 36:8247-8250  DOI:10.1016/0040-4039(95)01769-e
    • Wong, C. H., Alajarin, R., Morisvaras, F., Blanco, O., Garciajunceda, E. Enzymatic-synthesis of l-fucose and analogs Journal of Organic Chemistry  1995 60:7360-7363  DOI:10.1021/jo00127a052
    • Garciajunceda, E., Shen, G. J., Alajarin, R., Wong, C. H. Cloning and overexpression of rhamnose isomerase and fucose isomerase Bioorganic & Medicinal Chemistry  1995 3:1349-1355  DOI:10.1016/0968-0896(95)00119-2  PMID:8564401
    • Wong, C. H. Enzymatic and chemoenzymatic synthesis of carbohydrates Pure and Applied Chemistry  1995 67:1609-1616  DOI:10.1351/pac199567101609
    • Wetterholm, A., Haeggstrom, J. Z., Samuelsson, B., Yuan, W., Munoz, B., Wong, C. H. Potent and selective inhibitors of leukotriene a(4) hydrolase - effects on purified enzyme and human polymorphonuclear leukocytes Journal of Pharmacology and Experimental Therapeutics  1995 275:31-37  PMID:7562564
    • Gijsen, H. J. M., Wong, C. H. Synthesis of a cyclitol via a tandem enzymatic aldol - intramolecular horner-wadsworth-emmons reaction Tetrahedron Letters  1995 36:7057-7060  DOI:10.1016/0040-4039(95)01483-x
    • Lin, C. H., Shen, G. J., Garciajunceda, E., Wong, C. H. Enzymatic-synthesis and regeneration of 3'-phosphoadenosine 5'-phosphosulfate (PAPS) for regioselective sulfation of oligosaccharides Journal of the American Chemical Society  1995 117:8031-8032  DOI:10.1021/ja00135a028
    • Gijsen, H. J. M., Wong, C. H. Sequential 3-substrate and 4-substrate aldol reactions catalyzed by aldolases Journal of the American Chemical Society  1995 117:7585-7591  DOI:10.1021/ja00134a001
    • Vassilev, V. P., Uchiyama, T., Kajimoto, T., Wong, C. H. An efficient chemoenzymatic synthesis of alpha-amino-beta-hydroxy-gamma-butyrolactone Tetrahedron Letters  1995 36:5063-5064  DOI:10.1016/00404-0399(50)09242-
    • Garciajunceda, E., Shen, G. J., Sugai, T., Wong, C. H. A new strategy for the cloning, overexpression and one-step purification of 3 dhap-dependent aldolases - rhamnulose-1-phosphate aldolase, fuculose-1-phosphate aldolase and tagatose-1,6-diphosphate aldolase Bioorganic & Medicinal Chemistry  1995 3:945-953  DOI:10.1016/0968-0896(95)00077-t  PMID:7582972
    • Alajarin, R., Garciajunceda, E., Wong, C. H. A short enzymatic-synthesis of l-glucose from dihydroxyacetone phosphate and l-glyceraldehyde Journal of Organic Chemistry  1995 60:4294-4295  DOI:10.1021/jo00118a058
    • Fitz, W., Schwark, J. R., Wong, C. H. Aldotetroses and c(3)-modified aldohexoses as substrates for n-acetylneuraminic acid aldolase - a model for the explanation of the normal and the inversed stereoselectivity Journal of Organic Chemistry  1995 60:3663-3670  DOI:10.1021/jo00117a016
    • Vassilev, V. P., Uchiyama, T., Kajimoto, T., Wong, C. H. L-threonine aldolase in organic-synthesis - preparation of novel beta-hydroxy-alpha-amino acids Tetrahedron Letters  1995 36:4081-4084  DOI:10.1016/0040-4039(95)00720-w
    • Deluca, C., Lansing, M., Martini, I., Crescenzi, F., Shen, G. J., Oregan, M., Wong, C. H. Enzymatic-synthesis of hyaluronic-acid with regeneration of sugar nucleotides Journal of the American Chemical Society  1995 117:5869-5870  DOI:10.1021/ja00126a034
    • Huang, H. M., Wong, C. H. Synthesis of biologically-active sialyl-lewis-x mimetics Journal of Organic Chemistry  1995 60:3100-3106  DOI:10.1021/jo00115a027
    • Uchiyama, T., Vassilev, V. P., Kajimoto, T., Wong, W. C., Huang, H. M., Lin, C. C., Wong, C. H. Design and synthesis of sialyl-Lewis X mimetics Journal of the American Chemical Society  1995 117:5395-5396  DOI:10.1021/ja00124a037
    • Chou, W. C., Fotsch, C., Wong, C. H. Synthesis of nitrocyclitols based on enzymatic aldol reaction and intramolecular nitroaldol reaction Journal of Organic Chemistry  1995 60:2916-2917  DOI:10.1021/jo00114a051
    • Stura, E. A., Ghosh, S., Garciajunceda, E., Chen, L. R., Wong, C. H., Wilson, I. A. Crystallization and preliminary crystallographic data for class-i deoxyribose-5-phosphate aldolase from escherichia-coli - an application of reverse screening Proteins-Structure Function and Genetics  1995 22:67-72  DOI:10.1002/prot.340220110  PMID:7675789
    • Wang, P. G., Fitz, W., Wong, C. H. Making complex carbohydrates via enzymatic routes ChemTech  1995 25:22-32
    • Wong, C. H., Garciajunceda, E., Chen, L. R., Blanco, O., Gijsen, H. J. M., Steensma, D. H. Recombinant 2-deoxyribose-5-phosphate aldolase in organic-synthesis - use of sequential 2-substrate and 3-substrate aldol reactions Journal of the American Chemical Society  1995 117:3333-3339  DOI:10.1021/ja00117a003
    • Gijsen, H. J. M., Wong, C. H. Sequential one-pot aldol reactions catalyzed by 2-deoxyribose-5-phosphate aldolase and fructose-1,6-diphosphate aldolase Journal of the American Chemical Society  1995 117:2947-2948  DOI:10.1021/ja00115a038
    • Wong, C. H., Halcomb, R. L., Ichikawa, Y., Kajimoto, T. Enzymes in organic-synthesis - application to the problems of carbohydrate-recognition .1 Angewandte Chemie-International Edition  1995 34:412-432  DOI:10.1002/anie.199504121
    • Wong, C. H., Halcomb, R. L., Ichikawa, Y., Kajimoto, T. Enzymes in organic-synthesis - application to the problems of carbohydrate-recognition .2 Angewandte Chemie-International Edition  1995 34:521-546  DOI:10.1002/anie.199505211
    • Sugai, T., Lin, C. H., Shen, G. J., Wong, C. H. CMP-KDO synthetase: overproduction and application to the synthesis of CMP-KDO and analogs Bioorganic & Medicinal Chemistry  1995 3:313-320  DOI:10.1016/0968-0896(95)00023-a  PMID:7606392
    • Ikeda, T., Kajimoto, T., Nohara, T., Kinjo, J., Wong, C. H. Preparation of a neoglycolipid carrying the oligosaccharide component of saponin from albizzia julibrissin Tetrahedron Letters  1995 36:1509-1510  DOI:10.1016/0040-4039(95)00072-k
    • Defrees, S. A., Kosch, W., Way, W., Paulson, J. C., Sabesan, S., Halcomb, R. L., Huang, D. H., Ichikawa, Y., Wong, C. H. Ligand recognition by e-selectin - synthesis, inhibitory activity, and conformational-analysis of bivalent sialyl-lewis-x analogs Journal of the American Chemical Society  1995 117:66-79  DOI:10.1021/ja00106a008
    • Hogg, J. H., Ollmann, I. R., Haeggstrom, J. Z., Wetterholm, A., Samuelsson, B., Wong, C. H. Amino hydroxamic acids as potent inhibitors of leukotriene A4 hydrolase Bioorganic & Medicinal Chemistry  1995 3:1405-1415  DOI:10.1016/0968-0896(95)00128-4  PMID:8564408
    • Fang, J. M., Lin, C. H., Bradshaw, C. W., Wong, C. H. Enzymes in organic-synthesis - oxidoreductions Journal of the Chemical Society-Perkin Transactions 1  1995 967-978  DOI:10.1039/p19950000967
    • Ollmann, I. R., Hogg, J. H., Munoz, B., Haeggstrom, J. Z., Samuelsson, B., Wong, C. H. Investigation of the inhibition of leukotriene A4 hydrolase Bioorganic & Medicinal Chemistry  1995 3:969-995  DOI:10.1016/0968-0896(95)00078-u  PMID:7582974
    • Wong, C. H., Provencher, L., Porco, J. A., Jung, S. H., Wang, Y. F., Chen, L. R., Wang, R., Steensma, D. H. Synthesis and evaluation of homoaza sugars as glycosidase inhibitors Journal of Organic Chemistry  1995 60:1492-1501  DOI:10.1021/jo00111a007
    • Fitz, W., Wong, C. H. Combined use of subtilisin and n-acetylneuraminic acid aldolase for the synthesis of a fluorescent sialic-acid Journal of Organic Chemistry  1994 59:8279-8280  DOI:10.1021/jo00105a057
    • Siuzdak, G., Zheng, Z. L., Rhamphal, J. Y., Ichikawa, Y., Nicolaou, K. C., Gaeta, F. C. A., Chatman, K. S., Wong, C. H. Examination of the sialyl-lewis-x calcium complex by electrospray mass-spectrometry Bioorganic & Medicinal Chemistry Letters  1994 4:2863-2866  DOI:10.1016/s0960-894x(01)80829-5
    • Halcomb, R. L., Huang, H. M., Wong, C. H. Solution-phase and solid-phase synthesis of inhibitors of helicobacter-pylori attachment and e-selectin-mediated leukocyte adhesion Journal of the American Chemical Society  1994 116:11315-11322  DOI:10.1021/ja00104a011
    • Halcomb, R. L., Fitz, W., Wong, C. H. Enzymatic-synthesis of 7-deoxy-n-acetylneuraminic acid and 7-o-methyl-n-acetylneuraminic acid Tetrahedron-Asymmetry  1994 5:2437-2442  DOI:10.1016/s0957-4166(00)80390-0
    • Jung, S. H., Jeong, J. H., Miller, P., Wong, C. H. An efficient multigram-scale preparation of dihydroxyacetone phosphate Journal of Organic Chemistry  1994 59:7182-7184  DOI:10.1021/jo00102a060
    • Yuasa, H., Kajimoto, T., Wong, C. H. Synthesis of iminothiasugar as a potential transition-state analog inhibitor of glycosyltransfer reactions Tetrahedron Letters  1994 35:8243-8246  DOI:10.1016/0040-4039(94)88293-2
    • Herrmann, G. F., Wang, P., Shen, G. J., Garciajunceda, E., Khan, S. H., Matta, K. L., Wong, C. H. Large-scale production of recombinant alpha-1,2-mannosyltransferase from escherichia-coli for the study of acceptor specificity and use of the recombinant whole cells in synthesis Journal of Organic Chemistry  1994 59:6356-6362  DOI:10.1021/jo00100a043
    • Gijsen, H. J. M., Wong, C. H. Unprecedented asymmetric aldol reactions with 3 aldehyde substrates catalyzed by 2-deoxyribose-5-phosphate aldolase Journal of the American Chemical Society  1994 116:8422-8423  DOI:10.1021/ja00097a082
    • Marquardt, J. L., Brown, E. D., Lane, W. S., Haley, T. M., Ichikawa, Y., Wong, C. H., Walsh, C. T. Kinetics, stoichiometry, and identification of the reactive thiolate in the inactivation of udp-glcnac enolpyruvoyl transferase by the antibiotic fosfomycin Biochemistry  1994 33:10646-10651  DOI:10.1021/bi00201a011  PMID:8075065
    • Sears, P., Schuster, M., Wang, P., Witte, K., Wong, C. H. Engineering subtilisin for peptide coupling - studies on the effects of counterions and site-specific modifications on the stability and specificity of the enzyme Journal of the American Chemical Society  1994 116:6521-6530  DOI:10.1021/ja00094a005
    • Hiranuma, S., Kajimoto, T., Wong, C. H. A facile synthesis of 1-thiopentofuranoside Tetrahedron Letters  1994 35:5257-5260  DOI:10.1016/s0040-4039(00)77078-x
    • Chou, W. C., Chen, L. H., Fang, J. M., Wong, C. H. A new route to deoxythiosugars based on aldolases Journal of the American Chemical Society  1994 116:6191-6194  DOI:10.1021/ja00093a018
    • Fang, J. M., Wong, C. H. Enzymes in organic-synthesis - alteration of reversible-reactions to irreversible-processes Synlett  1994 393-402
    • Fotsch, C. H., Wong, C. H. Synthesis of a guanidino-sugar as a glycosyl cation mimic Tetrahedron Letters  1994 35:3481-3484  DOI:10.1016/s0040-4039(00)73215-1
    • Kondo, H., Aoki, S., Ichikawa, Y., Halcomb, R. L., Ritzen, H., Wong, C. H. Glycosyl phosphites as glycosylation reagents - scope and mechanism Journal of Organic Chemistry  1994 59:864-877  DOI:10.1021/jo00083a032
    • Schuster, M., Wang, P., Paulson, J. C., Wong, C. H. Solid-phase chemical-enzymatic synthesis of glycopeptides and oligosaccharides Journal of the American Chemical Society  1994 116:1135-1136  DOI:10.1021/ja00082a047
    • Ichikawa, Y., Halcomb, R. L., Wong, C. H. Sticky solutions Chemistry in Britain  1994 30:117-118, 120
    • Henderson, I., Sharpless, K. B., Wong, C. H. Synthesis of carbohydrates via tandem use of the osmium-catalyzed asymmetric dihydroxylation and enzyme-catalyzed aldol addition-reactions Journal of the American Chemical Society  1994 116:558-561  DOI:10.1021/ja00081a016
    • Henderson, I., Laslo, K., Wong, C. H. Chemoenzymatic synthesis of homoazasugars Tetrahedron Letters  1994 35:359-362  DOI:10.1016/0040-4039(94)85053-4
    • Aoki, S., Kondo, H., Wong, C. H. Glycosyl phosphites as glycosylation reagents Neoglycoconjugates, Pt B  1994 247:193-211  PMID:7898353
    • Herrmann, G. F., Wang, P., Shen, G. J., Wong, C. H. Recombinant whole cells as catalysts for the enzymatic-synthesis of oligosaccharides and glycopeptides Angewandte Chemie-International Edition  1994 33:1241-1242  DOI:10.1002/anie.199412411
    • Ichikawa, Y., Wang, R., Wong, C. H. Regeneration of sugar nucleotide for enzymatic oligosaccharide synthesis Neoglycoconjugates, Pt B  1994 247:107-127  PMID:7898347
    • Wang, Y. F., Takaoka, Y., Wong, C. H. Remarkable stereoselectivity in the inhibition of alpha-galactosidase from coffee bean by a new polyhydroxypyrrolidine inhibitor Angewandte Chemie-International Edition  1994 33:1242-1244  DOI:10.1002/anie.199412421
    • Wang, P., Schuster, M., Wang, Y. F., Wong, C. H. Synthesis of phospholipid inhibitor conjugates by enzymatic transphosphatidylation with phospholipase-d Journal of the American Chemical Society  1993 115:10487-10491  DOI:10.1021/ja00076a004
    • Halcomb, R. L., Wong, C. H. Synthesis of oligosaccharides, glycopeptides, and glycolipids Current Opinion in Structural Biology  1993 3:694-700  DOI:10.1016/0959-440x(93)90052-m
    • Takaoka, Y., Kajimoto, T., Wong, C. H. Inhibition of n-acetylglucosaminyltransfer enzymes - chemical-enzymatic synthesis of new 5-membered acetamido azasugars Journal of Organic Chemistry  1993 58:4809-4812  DOI:10.1021/jo00070a013
    • Defrees, S. A., Gaeta, F. C. A., Lin, Y. C., Ichikawa, Y., Wong, C. H. Ligand recognition by e-selectin - analysis of conformation and activity of synthetic monomeric and bivalent sialyl lewis-x analogs Journal of the American Chemical Society  1993 115:7549-7550  DOI:10.1021/ja00069a083
    • Look, G. C., Ichikawa, Y., Shen, G. J., Cheng, P. W., Wong, C. H. A combined chemical and enzymatic strategy for the construction of carbohydrate-containing antigen core units Journal of Organic Chemistry  1993 58:4326-4330  DOI:10.1021/jo00068a030
    • Wang, P., Shen, G. J., Wang, Y. F., Ichikawa, Y., Wong, C. H. Enzymes in oligosaccharide synthesis - active-domain overproduction, specificity study, and synthetic use of an alpha-1,2-mannosyltransferase with regeneration of gdp-man Journal of Organic Chemistry  1993 58:3985-3990  DOI:10.1021/jo00067a035
    • Wong, C. H., Schuster, M., Wang, P., Sears, P. Enzymatic-synthesis of N-linked and O-linked glycopeptides Journal of the American Chemical Society  1993 115:5893-5901  DOI:10.1021/ja00067a001
    • Herrmann, G. F., Ichikawa, Y., Wandrey, C., Gaeta, F. C. A., Paulson, J. C., Wong, C. H. A new multienzyme system for a one-pot synthesis of sialyl oligosaccharides - combined use of beta-galactosidase and alpha(2,6)-sialyltransferase coupled with regeneration insitu of cmp-sialic acid Tetrahedron Letters  1993 34:3091-3094  DOI:10.1016/s0040-4039(00)93387-2
    • Sugai, T., Ritzen, H., Wong, C. H. Towards the chemoenzymatic synthesis of lipid-a Tetrahedron-Asymmetry  1993 4:1051-1058  DOI:10.1016/s0957-4166(00)80153-6
    • Siuzdak, G., Ichikawa, Y., Caulfield, T. J., Munoz, B., Wong, C. H., Nicolaou, K. C. Evidence of ca2+-dependent carbohydrate association through ion spray mass-spectrometry Journal of the American Chemical Society  1993 115:2877-2881  DOI:10.1021/ja00060a040
    • Wong, C. H. Development of enzymes for chemoenzymatic synthesis Chimia  1993 47:127-132
    • Look, G. C., Fotsch, C. H., Wong, C. H. Enzyme-catalyzed organic-synthesis - practical routes to aza sugars and their analogs for use as glycoprocessing inhibitors Accounts of Chemical Research  1993 26:182-190  DOI:10.1021/ar00028a008
    • Wong, C. H., Ichikawa, Y., Kajimoto, T., Liu, K. K. C., Shen, G. J., Lin, C. H., Wang, Y. F., Dumas, D. P., Lin, Y. C., Wang, R., Look, G. C. Practical synthesis of carbohydrates based on aldolases and glycosyl transferases Pure and Applied Chemistry  1993 65:803-808  DOI:10.1351/pac199365040803
    • Sim, M. M., Kondo, H., Wong, C. H. Synthesis and use of glycosyl phosphites - an effective route to glycosyl phosphates, sugar nucleotides, and glycosides Journal of the American Chemical Society  1993 115:2260-2267  DOI:10.1021/ja00059a023
    • Schuster, M., Munoz, B., Yuan, W., Wong, C. H. Papain-catalyzed synthesis of peptide isosteres Tetrahedron Letters  1993 34:1247-1250  DOI:10.1016/s0040-4039(00)91765-9
    • Sugai, T., Shen, G. J., Ichikawa, Y., Wong, C. H. Synthesis of 3-deoxy-d-manno-2-octulosonic acid (kdo) and its analogs based on kdo aldolase-catalyzed reactions Journal of the American Chemical Society  1993 115:413-421  DOI:10.1021/ja00055a008
    • Wei, Y. A., Munoz, B., Wong, C. H., Haeggstrom, J. Z., Wetterholm, A., Samuelsson, B. Development of selective tight-binding inhibitors of leukotriene-a4 hydrolase Journal of Medicinal Chemistry  1993 36:211-220  PMID:8423594
    • Wang, Y. F., Dumas, D. P., Wong, C. H. Chemoenzymatic synthesis of 5-membered azasugars as inhibitors of fucosidase and fucosyl-transferase - an issue regarding the stereochemistry discrimination at transition-states Tetrahedron Letters  1993 34:403-406
    • Wong, C. H., Liu, K. K. C., Kajimoto, T., Chen, L., Zhong, Z., Dumas, D. P., Liu, J. L. C., Ichikawa, Y. Enzymes for carbohydrate and peptide syntheses Indian Journal of Chemistry Section B-Organic Chemistry Including Medicinal Chemistry  1993 32:135-139
    • Fu, H., Kondo, H., Ichikawa, Y., Look, G. C., Wong, C. H. Chloroperoxidase-catalyzed asymmetric-synthesis - enantioselective reactions of chiral hydroperoxides with sulfides and bromohydration of glycals Journal of Organic Chemistry  1992 57:7265-7270  DOI:10.1021/jo00052a048
    • Lin, C. H., Sugai, T., Halcomb, R. L., Ichikawa, Y., Wong, C. H. Unusual stereoselectivity in sialic-acid aldolase-catalyzed aldol condensations - synthesis of both enantiomers of high-carbon monosaccharides Journal of the American Chemical Society  1992 114:10138-10145  DOI:10.1021/ja00052a008
    • Wong, C. H., Liu, K. K. C., Kajimoto, T., Chen, L. R., Zhong, Z. Y., Ichikawa, Y., Shen, G. J. Developing better enzymes for organic-synthesis Annals of the New York Academy of Sciences  1992 672:343-351  DOI:10.1111/j.1749-6632.1992.tb35644.x  PMID:1476380
    • Ichikawa, Y., Lin, Y. C., Dumas, D. P., Shen, G. J., Garciajunceda, E., Williams, M. A., Bayer, R., Ketcham, C., Walker, L. E., Paulson, J. C., Wong, C. H. Chemical-enzymatic synthesis and conformational-analysis of sialyl lewis-x and derivatives Journal of the American Chemical Society  1992 114:9283-9298  DOI:10.1021/ja00050a007
    • Kondo, H., Ichikawa, Y., Wong, C. H. Beta-sialyl phosphite and phosphoramidite - synthesis and application to the chemoenzymatic synthesis of cmp-sialic acid and sialyl oligosaccharides Journal of the American Chemical Society  1992 114:8748-8750  DOI:10.1021/ja00048a085
    • Danishefsky, S. J., Gervay, J., Peterson, J. M., McDonald, F. E., Koseki, K., Oriyama, T., Griffith, D. A., Wong, C. H., Dumas, D. P. Remarkable regioselectivity in the chemical glycosylation of glycal acceptors - a concise solution to the synthesis of sialyl-lewis-x glycal Journal of the American Chemical Society  1992 114:8329-8331  DOI:10.1021/ja00047a077
    • Liu, K. K. C., Wong, C. H. A new strategy for the synthesis of nucleoside analogs based on enzyme-catalyzed aldol reactions Journal of Organic Chemistry  1992 57:4789-4791  DOI:10.1021/jo00044a005
    • Wong, C. H., Dumas, D. P., Ichikawa, Y., Koseki, K., Danishefsky, S. J., Weston, B. W., Lowe, J. B. Specificity, inhibition, and synthetic utility of a recombinant human alpha-1,3-fucosyl-transferase Journal of the American Chemical Society  1992 114:7321-7322  DOI:10.1021/ja00044a068
    • Wong, C. H., Liu, K. K. C., Kajimoto, T., Chen, L. H., Zhong, Z. Y., Dumas, D. P., Liu, J. L. C., Ichikawa, Y. Enzymes for carbohydrate and peptide syntheses Pure and Applied Chemistry  1992 64:1197-1202  DOI:10.1351/pac199264081197
    • Fernholz, E., Schloeder, D., Liu, K. K. C., Bradshaw, C. W., Huang, H. M., Janda, K., Lerner, R. A., Wong, C. H. Specificity of antibody-catalyzed transesterifications using enol esters - a comparison with lipase reactions Journal of Organic Chemistry  1992 57:4756-4761  DOI:10.1021/jo00043a042
    • Yuan, W., Wong, C. H., Haeggstrom, J. Z., Wetterholm, A., Samuelsson, B. Novel tight-binding inhibitors of leukotriene-a(4) hydrolase Journal of the American Chemical Society  1992 114:6552-6553  DOI:10.1021/ja00042a041
    • Look, G. C., Wong, C. H. A facile enzymatic-synthesis of gal-beta-1,3glucal - a key intermediate for the synthesis of le(a) and sialyl le(a) Tetrahedron Letters  1992 33:4253-4256  DOI:10.1016/s0040-4039(00)74231-6
    • Liu, K. K. C., Wong, C. H. Enzymatic halohydration of glycals Journal of Organic Chemistry  1992 57:3748-3750  DOI:10.1021/jo00039a050
    • Lin, Y. C., Hummel, C. W., Huang, D. H., Ichikawa, Y., Nicolaou, K. C., Wong, C. H. Conformational studies of sialyl lewis-x in aqueous-solution Journal of the American Chemical Society  1992 114:5452-5454  DOI:10.1021/ja00039a082
    • Ichikawa, Y., Sim, M. M., Wong, C. H. Efficient chemical synthesis of gdp-fucose Journal of Organic Chemistry  1992 57:2943-2946  DOI:10.1021/jo00036a036
    • Liu, J. L. C., Shen, G. J., Ichikawa, Y., Rutan, J. F., Zapata, G., Vann, W. F., Wong, C. H. Overproduction of cmp-sialic acid synthetase for organic-synthesis Journal of the American Chemical Society  1992 114:3901-3910  DOI:10.1021/ja00036a044
    • Ichikawa, Y., Look, G. C., Wong, C. H. Enzyme-catalyzed oligosaccharide synthesis Analytical Biochemistry  1992 202:215-238  DOI:10.1016/0003-2697(92)90099-s  PMID:1519746
    • Ichikawa, Y., Look, G. C., Wong, C. H., Kajimoto, T. Synthesis of oligosaccharides using glycosyltransferases Journal of Synthetic Organic Chemistry Japan  1992 50:441-450
    • Bradshaw, C. W., Lalonde, J. J., Wong, C. H. Enzymatic-synthesis of (r) and (s) 1-deuterohexanol Applied Biochemistry and Biotechnology  1992 33:15-24  DOI:10.1007/bf02922180  PMID:1416953
    • Bradshaw, C. W., Fu, H., Shen, G. J., Wong, C. H. A pseudomonas sp alcohol-dehydrogenase with broad substrate-specificity and unusual stereospecificity for organic-synthesis Journal of Organic Chemistry  1992 57:1526-1532  DOI:10.1021/jo00031a036
    • Bradshaw, C. W., Hummel, W., Wong, C. H. Lactobacillus-kefir alcohol-dehydrogenase - a useful catalyst for synthesis Journal of Organic Chemistry  1992 57:1532-1536  DOI:10.1021/jo00031a037
    • Chen, L. R., Dumas, D. P., Wong, C. H. Deoxyribose-5-phosphate aldolase as a catalyst in asymmetric aldol condensation Journal of the American Chemical Society  1992 114:741-748  DOI:10.1021/ja00028a050
    • Wong, C. H.*, Wang, R.*, Ichikawa, Y. Regeneration of sugar nucleotide for enzymic oligosaccharide synthesis: use of Gal-1-phosphate uridyltransferase in the regeneration of UDP-galactose, UDP-2-deoxygalactose, and UDP-galactosamine Journal of Organic Chemistry  1992 57:4343-4344  DOI:10.1021/jo00042a008 (* = equal contribution)
    • Dumas, D. P., Kajimoto, T., Liu, K. K. C., Wong, C. H., Berkowitz, D. B., Danishefsky, S. J. Azasugar and glycal inhibitors of alpha-l-fucosidase Bioorganic & Medicinal Chemistry Letters  1992 2:33-36  DOI:10.1016/s0960-894x(00)80649-6
    • Bradshaw, C. W., Shen, G. J., Wong, C. H. A new alcohol-dehydrogenase with unique stereospecificity from pseudomonas sp Bioorganic Chemistry  1991 19:398-417  DOI:10.1016/0045-2068(91)90022-h
    • Wong, C. H., Wang, K. T. New developments in enzymatic peptide-synthesis Experientia  1991 47:1123-1129  DOI:10.1007/bf01918376  PMID:1765124
    • Liu, K. K. C., Pederson, R. L., Wong, C. H. Fructose 1,6-diphosphate aldolase-catalyzed stereoselective c-c bond formation Journal of the Chemical Society-Perkin Transactions 1  1991 2669-2673  DOI:10.1039/p19910002669
    • Liu, K. K. C., Kajimoto, T., Chen, L. R., Zhong, Z. Y., Ichikawa, Y., Wong, C. H. Use of dihydroxyacetone phosphate dependent aldolases in the synthesis of deoxyazasugars Journal of Organic Chemistry  1991 56:6280-6289  DOI:10.1021/jo00022a013
    • Wong, C. H., Ichikawa, Y., Krach, T., Gautheronlenarvor, C., Dumas, D. P., Look, G. C. Probing the acceptor specificity of beta-1,4-galactosyltransferase for the development of enzymatic-synthesis of novel oligosaccharides Journal of the American Chemical Society  1991 113:8137-8145  DOI:10.1021/ja00021a045
    • Gautheronlenarvor, C., Ichikawa, Y., Wong, C. H. A complete change of stereoselectivity in sialic-acid aldolase reactions - a novel synthetic route to the kdo type of 9-carbon-l sugars Journal of the American Chemical Society  1991 113:7816-7818  DOI:10.1021/ja00020a084
    • Wong, C. H., Krach, T., Gautheronlenarvor, C., Ichikawa, Y., Look, G. C., Gaeta, F., Thompson, D., Nicolaou, K. C. Synthesis of novel disaccharides based on glycosyltransferases - beta-1,4galactosyltransferase Tetrahedron Letters  1991 32:4867-4870  DOI:10.1016/s0040-4039(00)93482-8
    • Barbas, C. F., Wong, C. H. Overexpression and substrate-specificity studies of phosphodeoxyribomutase and thymidine phosphorylase Bioorganic Chemistry  1991 19:261-269  DOI:10.1016/0045-2068(91)90051-p
    • Gautheronlenarvor, C., Wong, C. H. Glycosyltransferase-catalyzed stereoselective glycosidation of monosaccharide-based glycosidase inhibitors - a new approach to the synthesis of sequence-specific glycosidase inhibitors Journal of the Chemical Society-Chemical Communications  1991 1130-1131  DOI:10.1039/c39910001130
    • Kajimoto, T., Chen, L. R., Liu, K. K. C., Wong, C. H. Palladium-mediated stereocontrolled reductive amination of azido sugars prepared from enzymatic aldol condensation - a general-approach to the synthesis of deoxy aza sugars Journal of the American Chemical Society  1991 113:6678-6680  DOI:10.1021/ja00017a052
    • Ichikawa, Y., Liu, J. L. C., Shen, G. J., Wong, C. H. A highly efficient multienzyme system for the one-step synthesis of a sialyl trisaccharide - insitu generation of sialic-acid and n-acetyllactosamine coupled with regeneration of udp-glucose, udp-galactose, and cmp-sialic acid Journal of the American Chemical Society  1991 113:6300-6302  DOI:10.1021/ja00016a073
    • Kajimoto, T., Liu, K. K. C., Pederson, R. L., Zhong, Z. Y., Ichikawa, Y., Porco, J. A., Wong, C. H. Enzyme-catalyzed aldol condensation for asymmetric-synthesis of azasugars - synthesis, evaluation, and modeling of glycosidase inhibitors Journal of the American Chemical Society  1991 113:6187-6196  DOI:10.1021/ja00016a039
    • Fu, H., Newcomb, M., Wong, C. H. Pseudomonas-oleovorans monooxygenase catalyzed asymmetric epoxidation of allyl alcohol derivatives and hydroxylation of a hypersensitive radical probe with the radical ring-opening rate exceeding the oxygen rebound rate Journal of the American Chemical Society  1991 113:5878-5880  DOI:10.1021/ja00015a061
    • Drueckhammer, D. G., Hennen, W. J., Pederson, R. L., Barbas, C. F., Gautheron, C. M., Krach, T., Wong, C. H. Enzyme catalysis in synthetic carbohydrate-chemistry Synthesis-Stuttgart  1991 499-525
    • Nicolaou, K. C., Hummel, C. W., Bockovich, N. J., Wong, C. H. Stereocontrolled synthesis of sialyl lex, the oligosaccharide binding ligand to elam-1 (sialyl = n-acetylneuramin) Journal of the Chemical Society-Chemical Communications  1991 870-872  DOI:10.1039/c39910000870
    • Ichikawa, Y., Shen, G. J., Wong, C. H. Enzyme-catalyzed synthesis of sialyl oligosaccharide with insitu regeneration of cmp-sialic acid Journal of the American Chemical Society  1991 113:4698-4700  DOI:10.1021/ja00012a058
    • Fu, H., Shen, G. J., Wong, C. H. Asymmetric epoxidation of allyl alcohol derivatives by omega-hydroxylase from Pseudomonas oleovorans Recueil des Travaux Chimiques des Pays-Bas  1991 110:167-170  DOI:10.1002/recl.19911100506
    • Pederson, R. L., Esker, J., Wong, C. H. An improved synthesis of dihydroxyacetone phosphate Tetrahedron  1991 47:2643-2648  DOI:10.1016/s0040-4020(01)81796-8
    • Zhong, Z., Bibbs, J. A., Yuan, W., Wong, C. H. Active-site-directed modification of subtilisin Journal of the American Chemical Society  1991 113:2259-2263  DOI:10.1021/ja00006a052
    • Bradshaw, C. W., Wong, C. H., Hummel, W., Kula, M. R. Enzyme-catalyzed asymmetric-synthesis of (s)-2-amino-4-phenylbutanoic acid and (r)-2-hydroxy-4-phenylbutanoic acid Bioorganic Chemistry  1991 19:29-39  DOI:10.1016/0045-2068(91)90041-m
    • Zhong, Z. Y., Liu, J. L. C., Dinterman, L. M., Finkelman, M. A. J., Mueller, W. T., Rollence, M. L., Whitlow, M., Wong, C. H. Engineering subtilisin for reaction in dimethylformamide Journal of the American Chemical Society  1991 113:683-684  DOI:10.1021/ja00002a051
    • Wong, C. H. Aldolases in synthesis of fluorosugars ACS Symposium Series  1991 456:156-162  DOI:10.1021/bk-1991-0456.ch010
    • Zhong, Z. Y., Wong, C. H. Development of new enzymatic catalysts for peptide-synthesis in aqueous and organic-solvents Biomedica Biochimica Acta  1991 50:S9-S14  PMID:1820067
    • Wong, C. H., Shen, G. J., Pederson, R. L., Wang, Y. F., Hennen, W. J. Enzymatic catalysis in organic-synthesis Methods in Enzymology  1991 202:591-620  DOI:10.1016/0076-6879(91)02028-8  PMID:1784190
    • Dumas, D. P., Ichikawa, Y., Wong, C. H., Lowe, J. B., Nair, R. P. Enzymatic-synthesis of sialyl lex and derivatives based on a recombinant fucosyl-transferase Bioorganic & Medicinal Chemistry Letters  1991 1:425-428  DOI:10.1016/s0960-894x(00)80270-x
    • Wong, C. H. Microbial aldolases in carbohydrate synthesis ACS Symposium Series  1991 466:23-37  DOI:10.1021/bk-1991-0466.ch002
    • Yuan, W., Zhong, Z., Wong, C. H. Probing the inhibition of leukotriene-a4 hydrolase based on its aminopeptidase activity Bioorganic & Medicinal Chemistry Letters  1991 1:551-556  DOI:10.1016/s0960-894x(01)80464-9
    • Vonderosten, C. H., Gioannetti, C., Barbas, C., Pederson, R. L., Wang, Y. F., Wong, C. H., Ozaki, A., Toone, E., Whitesides, G. M., Sinskey, A. J. Molecular-cloning of aldolases for synthetic applications Annals of the New York Academy of Sciences  1990 613:771-775  PMID:2076016
    • Pederson, R. L., Liu, K. K. C., Rutan, J. F., Chen, L., Wong, C. H. Enzymes in organic-synthesis - synthesis of highly enantiomerically pure 1,2-epoxy aldehydes, epoxy alcohols, thiirane, aziridine, and glyceraldehyde-3-phosphate Journal of Organic Chemistry  1990 55:4897-4901  DOI:10.1021/jo00303a026
    • West, J. B., Hennen, W. J., Lalonde, J. L., Bibbs, J. A., Zhong, Z. Y., Meyer, E. F., Wong, C. H. Enzymes as synthetic catalysts - mechanistic and active-site considerations of natural and modified chymotrypsin Journal of the American Chemical Society  1990 112:5313-5320  DOI:10.1021/ja00169a043
    • Babiak, K. A., Ng, J. S., Dygos, J. H., Weyker, C. L., Wang, Y. F., Wong, C. H. Lipase-catalyzed irreversible transesterification using enol esters - resolution of prostaglandin synthons 4-hydroxy-2-alkyl-2-cyclopentenones and inversion of the 4s enantiomer to the 4r enantiomer Journal of Organic Chemistry  1990 55:3377-3381  DOI:10.1021/jo00297a073
    • Shen, G. J., Wang, Y. F., Bradshaw, C., Wong, C. H. A new nad-dependent alcohol-dehydrogenase with opposite facial selectivity useful for asymmetric reduction and cofactor regeneration Journal of the Chemical Society-Chemical Communications  1990 677-679  DOI:10.1039/c39900000677
    • Barbas, C. F., Wang, Y. F., Wong, C. H. Deoxyribose-5-phosphate aldolase as a synthetic catalyst Journal of the American Chemical Society  1990 112:2013-2014  DOI:10.1021/ja00161a064
    • Wong, C. H., Chen, S. T., Hennen, W. J., Bibbs, J. A., Wang, Y. F., Liu, J. L. C., Pantoliano, M. W., Whitlow, M., Bryan, P. N. Enzymes in organic synthesis: use of subtilisin and a highly stable mutant derived from multiple site-specific mutations Journal of the American Chemical Society  1990 112:945-953  DOI:10.1021/ja00159a006
    • Hsu, S. H., Wu, S. S., Wang, Y. F., Wong, C. H. Lipase-catalyzed irreversible transesterification using enol esters - xad-8 immobilized lipoprotein lipase-catalyzed resolution of secondary alcohols Tetrahedron Letters  1990 31:6403-6406  DOI:10.1016/s0040-4039(00)97076-x
    • Vonderosten, C. H., Barbas, C. F., Wong, C. H., Sinskey, A. J. Molecular-cloning, nucleotide-sequence and fine-structural analysis of the corynebacterium-glutamicum fda gene - structural comparison of corynebacterium-glutamicum fructose-1,6-biphosphate aldolase to class-i and class-ii aldolases Molecular Microbiology  1989 3:1625-1637  PMID:2615658
    • Wang, Y. F., Wong, C. H. Enantioselective syntheses of platelet-activating factor and a phospholipase-a2 inhibitor from chiral synthons prepared enzymatically Journal of the Chinese Chemical Society  1989 36:463-468
    • Chen, S. T., Wong, C. H. Studies on angiotensin-converting enzyme-inhibitors - protease catalyzed resolution of aryl 3-mercapto-2-methylpropionic ester Journal of the Chinese Chemical Society  1989 36:451-458
    • Hennen, W. J., Wong, C. H. A new method for the enzymatic-synthesis of nucleosides using purine nucleoside phosphorylase Journal of Organic Chemistry  1989 54:4692-4695  DOI:10.1021/jo00280a046
    • Wong, C. H. Enzymatic catalysts in organic-synthesis Science  1989 244:1145-1152  DOI:10.1126/science.2658059  PMID:2658059
    • Vonderosten, C. H., Sinskey, A. J., Barbas, C. F., Pederson, R. L., Wang, Y. F., Wong, C. H. Use of a recombinant bacterial fructose-1,6-diphosphate aldolase in aldol reactions - preparative syntheses of 1-deoxynojirimycin, 1-deoxymannojirimycin, 1,4-dideoxy-1,4-imino-d-arabinitol, and fagomine Journal of the American Chemical Society  1989 111:3924-3927  DOI:10.1021/ja00193a025
    • Drueckhammer, D. G., Durrwachter, J. R., Pederson, R. L., Crans, D. C., Daniels, L., Wong, C. H. Reversible and insitu formation of organic arsenates and vanadates as organic phosphate mimics in enzymatic-reactions - mechanistic investigation of aldol reactions and synthetic applications Journal of Organic Chemistry  1989 54:70-77  DOI:10.1021/jo00262a021
    • Pederson, R. L., Wong, C. H. Enzymatic aldol condensation as a route to heterocycles: synthesis of 1,4-dideoxy-1,4-imino-D-arabinitol, fagomine, 1-deoxynojirimycin and 1-deoxymannojirimycin Heterocycles  1989 28:477-480  DOI:10.3987/COM-88-S99
    • Wong, C. H., Drueckhammer, D. G., Durrwachter, J. R., Lacher, B., Chauvet, C. J., Wang, Y. F., Sweers, H. M., Smith, G. L., Yang, L. J. S., Hennen, W. J. Enzyme-catalyzed synthesis of carbohydrates ACS Symposium Series  1989 386:317-335  DOI:10.1021/bk-1989-0386.ch018
    • Wang, Y. F., Chen, S. T., Liu, K. K. C., Wong, C. H. Lipase-catalyzed irreversible trans-esterification using enol esters - resolution of cyanohydrins and syntheses of ethyl (r)-2-hydroxy-4-phenylbutyrate and (s)-propranolol Tetrahedron Letters  1989 30:1917-1920  DOI:10.1016/s0040-4039(00)99613-8
    • Hennen, W. J., Sweers, H. M., Wang, Y. F., Wong, C. H. Enzymes in carbohydrate synthesis - lipase-catalyzed selective acylation and deacylation of furanose and pyranose derivatives Journal of Organic Chemistry  1988 53:4939-4945  DOI:10.1021/jo00256a008
    • Wang, Y. F., Lalonde, J. J., Momongan, M., Bergbreiter, D. E., Wong, C. H. Lipase-catalyzed irreversible transesterifications using enol esters as acylating reagents - preparative enantioselective and regioselective syntheses of alcohols, glycerol derivatives, sugars, and organometallics Journal of the American Chemical Society  1988 110:7200-7205  DOI:10.1021/ja00229a041
    • Kim, M. J., Hennen, W. J., Sweers, H. M., Wong, C. H. Enzymes in carbohydrate synthesis - n-acetylneuraminic acid aldolase catalyzed-reactions and preparation of n-acetyl-2-deoxy-d-neuraminic acid-derivatives Journal of the American Chemical Society  1988 110:6481-6486  DOI:10.1021/ja00227a031
    • Durrwachter, J. R., Wong, C. H. Fructose 1,6-diphosphate aldolase catalyzed stereoselective synthesis of c-alkyl and n-containing sugars - thermodynamically controlled c-c bond formations Journal of Organic Chemistry  1988 53:4175-4181  DOI:10.1021/jo00253a004
    • Barbas, C. F., Matos, J. R., West, J. B., Wong, C. H. A search for peptide ligase: cosolvent-mediated conversion of proteases to esterases for irreversible synthesis of peptides Journal of the American Chemical Society  1988 110:5162-5166  DOI:10.1021/ja00223a042
    • West, J. B., Scholten, J., Stolowich, N. J., Hogg, J. L., Scott, A. I., Wong, C. H. Modification of proteases to esterases for peptide-synthesis - methylchymotrypsin Journal of the American Chemical Society  1988 110:3709-3710  DOI:10.1021/ja00219a083
    • Lalonde, J. J., Bergbreiter, D. E., Wong, C. H. Enzymatic kinetic resolution of alpha-nitro alpha-methyl carboxylic-acids Journal of Organic Chemistry  1988 53:2323-2327  DOI:10.1021/jo00245a036
    • Drueckhammer, D. G., Barbas, C. F., Nozaki, K., Wong, C. H., Wood, C. Y., Ciufolini, M. A. Chemoenzymic synthesis of chiral furan-derivatives - useful building-blocks for optically-active structures Journal of Organic Chemistry  1988 53:1607-1611  DOI:10.1021/jo00243a003
    • Pederson, R. L., Kim, M. J., Wong, C. H. A combined chemical and enzymatic procedure for the synthesis of 1-deoxynojirimycin and 1-deoxymannojirimycin Tetrahedron Letters  1988 29:4645-4648  DOI:10.1016/s0040-4039(00)80570-5
    • Wong, C. H., Dreckhammer, D. G., Sweers, H. M. Chemoenzymatic synthesis of fluorosugars ACS Symposium Series  1988 374:29-42  DOI:10.1021/bk-1988-0374.ch003
    • Barbas, C. F., Wong, C. H. One-pot tripeptide syntheses from 3 single amino-acid derivatives catalyzed by papain Tetrahedron Letters  1988 29:2907-2910  DOI:10.1016/0040-4039(88)85044-5
    • Drueckhammer, D. G., Sadozai, S. K., Wong, C. H., Roberts, S. M. Biphasic one-pot synthesis of two useful and separable compounds using nicotinamide cofactor-requiring enzymes: syntheses of (S)-4-hydroxyhexanoate and its lactone Enzyme and Microbial Technology  1987 9:564-570  DOI:10.1016/0141-0229(87)90089-5
    • Barbas, C. F., Wong, C. H. Papain catalyzed peptide-synthesis - control of amidase activity and the introduction of unusual amino-acids Journal of the Chemical Society-Chemical Communications  1987 533-534  DOI:10.1039/c39870000533
    • Matos, J. R., West, J. B., Wong, C. H. Lipase catalyzed synthesis of peptides - preparation of a penicillin-g precursor and other peptides Biotechnology Letters  1987 9:233-236  DOI:10.1007/bf01027155
    • Matos, J. R., Wong, C. H. S-adenosylmethionine - stability and stabilization Bioorganic Chemistry  1987 15:71-80  DOI:10.1016/0045-2068(87)90008-3
    • Matos, J. R., Raushel, F. M., Wong, C. H. S-adenosylmethionine - studies on chemical and enzymatic-synthesis Biotechnology and Applied Biochemistry  1987 9:39-52  PMID:3566918
    • Crans, D. C., Kazlauskas, R. J., Hirschbein, B. L., Wong, C. H., Abril, O., Whitesides, G. M. Enzymatic regeneration of adenosine 5'-triphosphate: acetyl phosphate, phosphoenolpyruvate, methoxycarbonyl phosphate, dihydroxyacetone phosphate, 5-phospho-alpha-D-ribosyl pyrophosphate, uridine-5'-diphosphoglucose Methods in Enzymology  1987 136:263-280  DOI:10.1016/S0076-6879(87)36027-6  PMID:2446104
    • West, J. B., Wong, C. H. Use of nonproteases in peptide-synthesis Tetrahedron Letters  1987 28:1629-1632  DOI:10.1016/s0040-4039(00)95377-2
    • Durrwachter, J. R., Drueckhammer, D. G., Nozaki, K., Sweers, H. M., Wong, C. H. Enzymatic aldol condensation isomerization as a route to unusual sugar-derivatives Journal of the American Chemical Society  1986 108:7812-7818  DOI:10.1021/ja00284a053  PMID:22283291
    • Chen, S. T., Wang, K. T., Wong, C. H. Chirally selective hydrolysis of d,l-amino acid-esters by alkaline protease Journal of the Chemical Society-Chemical Communications  1986 1514-1516  DOI:10.1039/c39860001514
    • Sweers, H. M., Wong, C. H. Enzyme-catalyzed regioselective deacylation of protected sugars in carbohydrate synthesis Journal of the American Chemical Society  1986 108:6421-6422  DOI:10.1021/ja00280a068
    • West, J. B., Wong, C. H. Enzyme-catalyzed irreversible formation of peptides containing d-amino acids Journal of Organic Chemistry  1986 51:2728-2735  DOI:10.1021/jo00364a021
    • Matos, J. R., Wong, C. H. Biphasic one-pot synthesis of 2 useful and separable compounds using cofactor-requiring enzymatic-reactions - glutamate-dehydrogenase catalyzed synthesis of l-alpha-aminoadipate coupled with alcohol-dehydrogenase catalyzed synthesis of a chiral lactone Journal of Organic Chemistry  1986 51:2388-2389  DOI:10.1021/jo00362a045
    • West, J. B., Wong, C. H. Enzyme-catalyzed synthesis of peptides containing d-amino acids Journal of the Chemical Society-Chemical Communications  1986 417-418  DOI:10.1039/c39860000417
    • Durrwachter, J. R., Sweers, H. M., Nozaki, K., Wong, C. H. Enzymatic aldol reaction isomerization as a route to unusual sugars Tetrahedron Letters  1986 27:1261-1264  DOI:10.1016/s0040-4039(00)84233-1
    • Drueckhammer, D. G., Riddle, V. W., Wong, C. H. Fmn reductase catalyzed regeneration of nad(p) for use in enzymatic-synthesis Journal of Organic Chemistry  1985 50:5387-5389  DOI:10.1021/jo00225a080
    • Wong, C. H., Matos, J. R. Enantioselective oxidation of 1,2-diols to l-alpha-hydroxy acids using coimmobilized alcohol and aldehyde dehydrogenases as catalysts Journal of Organic Chemistry  1985 50:1992-1994  DOI:10.1021/jo00211a046
    • Matos, J. R., Smith, M. B., Wong, C. H. Enantioselectivity of alcohol dehydrogenase-catalyzed oxidation of 1,2-diols and aminoalcohols Bioorganic Chemistry  1985 13:121-130  DOI:10.1016/0045-2068(85)90014-8
    • Wong, C. H., Drueckhammer, D. G. Enzymatic synthesis of chiral hydroxy compounds using immobilized glucose dehydrogenase from Bacillus cereus for NAD(P)H regeneration Bio-Technology  1985 3:649-651  DOI:10.1038/nbt0785-649
    • Wong, C. H., Drueckhammer, D. G., Sweers, H. M. Enzymatic vs fermentative synthesis - thermostable glucose-dehydrogenase catalyzed regeneration of nad(p)h for use in enzymatic-synthesis Journal of the American Chemical Society  1985 107:4028-4031  DOI:10.1021/ja00299a044
    • Root, R. L., Durrwachter, J. R., Wong, C. H. Enzymatic-synthesis of unusual sugars - galactose-oxidase catalyzed stereospecific oxidation of polyols Journal of the American Chemical Society  1985 107:2997-2999  DOI:10.1021/ja00296a041
    • Whitesides, G. M., Wong, C. H. Enzymes as catalysts in synthetic organic-chemistry Angewandte Chemie-International Edition  1985 24:617-638  DOI:10.1002/anie.198506173
    • Wong, C. H., Mazenod, F. P., Whitesides, G. M. Chemical and enzymatic syntheses of 6-deoxyhexoses - conversion to 2,5-dimethyl-4-hydroxy-2,3-dihydrofuran-3-one (furaneol) and analogs Journal of Organic Chemistry  1983 48:3493-3497  DOI:10.1021/jo00168a023
    • Wong, C. H., Whitesides, G. M. Enzyme-catalyzed organic-synthesis - regeneration of deuterated nicotinamide cofactors for use in large-scale enzymatic-synthesis of deuterated substances Journal of the American Chemical Society  1983 105:5012-5014  DOI:10.1021/ja00353a026
    • Wong, C. H., Haynie, S. L., Whitesides, G. M. Preparation of a mixture of nucleoside triphosphates from yeast rna - use in enzymatic-synthesis requiring nucleoside triphosphate regeneration and conversion to nucleoside diphosphate sugars Journal of the American Chemical Society  1983 105:115-117  DOI:10.1021/ja00339a021
    • Wong, C. H., Whitesides, G. M. Synthesis of sugars by aldolase-catalyzed condensation-reactions Journal of Organic Chemistry  1983 48:3199-3205  DOI:10.1021/jo00167a012
    • Whitesides, G. M., Wong, C. H., Pollak, A. Asymmetric synthesis using cofactor-requiring enzymes ACS Symposium Series  1982 185:205-218  DOI:10.1021/bk-1982-0185.ch015
    • Wong, C. H., Haynie, S. L., Whitesides, G. M. Enzyme-catalyzed synthesis of n-acetyllactosamine with insitu regeneration of uridine 5'-diphosphate glucose and uridine 5'-diphosphate galactose Journal of Organic Chemistry  1982 47:5416-5418  DOI:10.1021/jo00148a045
    • Wong, C. H., Whitesides, G. M. Enzyme-catalyzed transhydrogenation between nicotinamide cofactors and its application in organic-synthesis Journal of the American Chemical Society  1982 104:3542-3544  DOI:10.1021/ja00376a067
    • Wong, C. H., Pollak, A., McCurry, S. D., Sue, J. M., Knowles, J. R., Whitesides, G. M. Synthesis of ribulose 1,5-bisphosphate - routes from glucose-6-phosphate (via 6-phosphogluconate) and from adenosine-monophosphate (via ribose 5-phosphate) Methods in Enzymology  1982 89:108-121  PMID:7144568
    • Dicosimo, R., Wong, C. H., Daniels, L., Whitesides, G. M. Enzyme-catalyzed organic synthesis: electrochemical regeneration of NAD(P)H from NAD(P) using methyl viologen and flavoenzymes Journal of Organic Chemistry  1981 46:4622-4623  DOI:10.1021/jo00335a078
    • Wong, C. H., Whitesides, G. M. Enzyme-catalyzed organic-synthesis - nad(p)h cofactor regeneration by using glucose-6-phosphate and the glucose-6-phosphate-dehydrogenase from leuconostoc-mesenteroides Journal of the American Chemical Society  1981 103:4890-4899  DOI:10.1021/ja00406a037
    • Wong, C. H., Daniels, L., Ormejohnson, W. H., Whitesides, G. M. Enzyme-catalyzed organic-synthesis - nad(p)h regeneration using dihydrogen and the hydrogenase from methanobacterium-thermoautotrophicum Journal of the American Chemical Society  1981 103:6227-6228  DOI:10.1021/ja00410a049
    • Wong, C. H., Gordon, J., Cooney, C. L., Whitesides, G. M. Regeneration of nad(p)h using glucose 6-sulfate and glucose-6-phosphate-dehydrogenase Journal of Organic Chemistry  1981 46:4676-4679  DOI:10.1021/jo00336a009
    • Wong, C. H., McCurry, S. D., Whitesides, G. M. Practical enzymatic syntheses of ribulose 1,5-bisphosphate and ribose 5-phosphate Journal of the American Chemical Society  1980 102:7938-7939  DOI:10.1021/ja00547a023
    • Chou, S. H., Wong, C. H., Chen, S. T., Wang, K. T. Enzymatic-synthesis of oligopeptide .2. Synthesis of bis-(n-protected amino-acid) hydrazides by papain Journal of the Chinese Chemical Society  1979 26:11-15
    • Wong, C. H., Chen, S. T., Wang, K. T. Enzymic-synthesis of opioid peptides Biochimica et Biophysica Acta  1979 576:247-249  DOI:10.1016/0005-2795(79)90500-2  PMID:760808
    • Wong, C. H. Resolution of rs-mandelic acid Journal of the Chinese Chemical Society  1979 26:75-78
    • Wong, C. H., Wang, K. T. Electrochemistry in organic-synthesis .1. Large-scale preparation of cysteine from cystine Journal of the Chinese Chemical Society  1978 25:149-151
    • Chou, S. H., Chen, S. T., Wong, C. H., Wang, K. T. Enzymatic-synthesis of oligopeptide .1. Papain-catalyzed synthesis of dipeptide, tripeptide and tetrapeptide Journal of the Chinese Chemical Society  1978 25:215-218
    • Wong, C. H., Wang, K. T. Mutual resolution of (+)-ephedrine and z-dl-amino acid-induced by seeding chiral salt Tetrahedron Letters  1978 3813-3816
    • Wong, C. H., Wang, K. T. Mutual resolution of dl-ephedrine and n-benzyloxycarbonyl-dl-amino acids Journal of the Chinese Chemical Society  1978 25:209-214
    • Wong, C. H., Ho, M. F., Wang, K. T. Preparation of optically pure n-tert-butyloxycarbonyl-o-benzyl-l-serine and its antipode Journal of Organic Chemistry  1978 43:3604-3604  DOI:10.1021/jo00412a042
    • Wong, C. H., Ho, C. L., Wang, K. T. Purification of synthetic cardiotoxin by affinity chromatography Journal of Chromatography  1978 154:25-32  PMID:670366
    • Wong, C. H., Chen, Y. H., Hung, M. C., Wang, K. T., Ho, C. L., Lo, T. B. Renaturation of a reduced taiwan cobra cardiotoxin Biochimica et Biophysica Acta  1978 533:105-111  DOI:10.1016/0005-2795(78)90553-6  PMID:76481
    • Wong, C. H., Chen, S. T., Ho, C. L., Wang, K. T. Synthesis of a fully active snake-venom cardiotoxin by fragment condensation on solid polymer Biochimica et Biophysica Acta  1978 536:376-389  DOI:10.1016/0005-2795(78)90496-8  PMID:81691
    • Wong, C. H., Chen, S. T., Wang, K. T. Resolution of amino-acids by enzymes .1. Proteolytic-enzyme bromelain for hydrolysis of l-amino-acid methyl-esters Journal of the Chinese Chemical Society  1977 24:129-133
    • Kong, F. T., Lin, T. C., Wong, C. H., Wang, K. T. Synthesis of taiwan cobra venom cardiotoxin .2. Synthesis of protected hexapeptide, sequence 44-49 and protected tripeptide, sequence 50-52 Journal of the Chinese Chemical Society  1976 23:155-164
  • chapter

    • Calarese, D., Scanlan, C., Lee, H. K., Rudd, P., Dwek, R. Toward a carbohydrate-based HIV-1 vaccine ACS Symposium Series. 161-185. 2006  DOI:10.1021/bk-2006-0932.ch007

featured in

  • AIDS Researchers Isolate New Potent and Broadly Effective Antibodies Against HIV  News Release
  • Chi-Huey Wong Wins Prestigious Wolf Prize in Chemistry  Newsletter
  • Scientists Reveal Surprising Picture of How Powerful Antibody Neutralizes HIV  News Release
  • Scripps Research Scientists Develop Powerful New Methodology for Stabilizing Proteins  News Release
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Research

research overview

  • Research in the Wong lab encompasses a broad spectrum of bioorganic and synthetic chemistry. Development of small molecules targeting RNA and design and synthesis of inhibitors to enzymes and receptors are being performed to investigate how small molecules interact with biologically important molecules and in turn, learn more about the function of those molecules. Development of both synthetic and bioorganic strategies is also paramount to our research. Programmable one-pot reactions can be used for the synthesis of complex oligosaccharides and glycoarrays, and compliment development of new enzymatic catalysts for glycoprotein synthesis and other organic reactions.
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Teaching

advisees

  • graduate advising relationship

    • Dean, Stephen M, Ph.D.  candidate, 2005 - 2011
    • Wang, Sheng-Kai, Ph.D.  candidate, 2003 - 2008
    • Hanson, Sarah, Ph.D.  candidate, 2003 - 2007
    • Yang, Yu-Ying, Ph.D.  candidate, 2002 - 2007
    • Thayer, Desiree, Ph.D.  candidate, 2002 - 2006
    • Wu, Douglass, Ph.D.  candidate, 2002 - 2006
    • Huang, Cheng-Yuan, Ph.D.  candidate, 2001 - 2005
    • Liang, Fu-Sen, Ph.D.  candidate, 2001 - 2005
    • Liu, Haitian, Ph.D.  candidate, 2000 - 2005
    • Bryan, Marian C, Ph.D.  candidate, 2000 - 2004
    • Lin, David Wei, Ph.D.  candidate, 2002 - 2004
    • Nyffeler, Paul, Ph.D.  candidate, 2000 - 2004
    • Ritter, Thomas Kurt, Ph.D.  candidate, 1999 - 2003
    • Chapman, Eli, Ph.D.  candidate, 1998 - 2002
    • Liu, Junjie, Ph.D.  candidate, 1998 - 2002
    • Mitchell, Michael, Ph.D.  candidate, 1998 - 2002
    • Koeller, Kathryn, Ph.D.  candidate, 1997 - 2000
    • Burkart, Michael David, Ph.D.  candidate, 1995 - 1999
    • Alper, Phillip, Ph.D.  candidate, 1994 - 1998
    • Ollmann, Ian Russell, Ph.D.  candidate, 1993 - 1998
    • Takayama, Shuichi, Ph.D.  candidate, 1995 - 1998
    • Witte, Krista Leah, Ph.D.  candidate, 1993 - 1998
    • Hendrix, Martin, Ph.D.  candidate, 1994 - 1997
    • Hogg, Heather, Ph.D.  candidate, 1992 - 1997
    • Laslo, Karen, Ph.D.  candidate, 1993 - 1997
    • Lin, Chun-Cheng, Ph.D.  candidate, 1994 - 1997
    • Sears, Pamela, Ph.D.  candidate, 1992 - 1996
    • Huang, Hongmei, Ph.D.  candidate, 1992 - 1995
    • Lin, Chun-Hung, Ph.D.  candidate, 1991 - 1995
    • Sim, Mui Mui, Ph.D.  candidate, 1991 - 1995
    • Steensma, Ruo Wang, Ph.D.  candidate, 1991 - 1995
  • postdoc or fellow advising relationship

    • Wang, Sheng-Kai, Ph.D.  candidate, 2008 - 2013
    • Liu, Junjie, Ph.D.  candidate, 2003 - 2004
    • Sears, Pamela, Ph.D.  candidate, 1996 - 1997
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Background

education and training

  • Ph.D. in Organic Chemistry, Massachusetts Institute of Technology , with G.M. Whitesides 1982
  • M.S. in Biochemical Sciences, National Taiwan University 1977
  • B.S. in Chemistry & Biochemical Sciences, National Taiwan University 1970

awards and honors

  • Wolf Prize in Chemistry, conferred by Wolf Foundation, 2014
  • Arthur C. Cope Scholar Award, 2012
  • Member (National Academy of Sciences), 2002
  • Member (American Academy of Arts and Sciences), 1996
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Contact

full name

  • Chi-Huey Wong

geographic location

  • Scripps California 

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