Wong, Chi-Huey

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- Woodring, J. L., Lu, S. H., Krasnova, L., Wang, S. C., Chen, J. B., Chou, C. C., Huang, Y. C., Cheng, T. J. R., Wu, Y. T., Chen, Y. H., Fang, J. M., Tsai, M. D., et al. Disrupting the conserved salt bridge in the trimerization of influenza A nucleoprotein Journal of Medicinal Chemistry 2020 63:205-215 DOI:10.1021/acs.jmedchem.9b01244 PMID:31769665
- Dey, S., Lo, H. J., Wong, C. H. Programmable One-Pot Synthesis of Heparin Pentasaccharide Fondaparinux Organic Letters 2020 22:4638-4642 DOI:10.1021/acs.orglett.0c01386 PMID:32496799 PMCID:PMC7347301
- Chiu, L. T., Sabbavarapu, N. M., Lin, W. C., Fan, C. Y., Wu, C. C., Cheng, T. J. R., Wong, C. H., Hung, S. C. Trisaccharide Sulfate and Its Sulfonamide as an Effective Substrate and Inhibitor of Human Endo-O-sulfatase-1 Journal of the American Chemical Society 2020 142:5282-5292 DOI:10.1021/jacs.0c00005 PMID:32083852
- Dey, S., Lo, H. J., Wong, C. H. An efficient modular one-pot synthesis of heparin-based anticoagulant idraparinux Journal of the American Chemical Society 2019 141:10309-10314 DOI:10.1021/jacs.9b03266 PMID:31244187
- Cheng, C. W., Zhou, Y., Pan, W. H., Dey, S., Wu, C. Y., Hsu, W. L., Wong, C. H. Hierarchical and programmable one-pot oligosaccharide synthesis Journal of Visualized Experiments : JoVE 2019 DOI:10.3791/59987 PMID:31545316
- Wong, C. H., Krasnova, L. Highlights in chemical glycobiology Israel Journal of Chemistry 2019 59:18-22 DOI:10.1002/ijch.201800139
- Krasnova, L., Wong, C. H. Oligosaccharide synthesis and translational innovation Journal of the American Chemical Society 2019 141:3735-3754 DOI:10.1021/jacs.8b11005 PMID:30716271
- Lo, H. J., Krasnova, L., Dey, S., Cheng, T., Liu, H., Tsai, T. I., Wu, K. B., Wu, C. Y., Wong, C. H. Synthesis of sialidase-resistant oligosaccharide and antibody glycoform containing α2,6-linked 3Fax-Neu5Ac Journal of the American Chemical Society 2019 141:6484-6488 DOI:10.1021/jacs.9b01991 PMID:30969765
- Zhou, T., Zheng, A., Baxa, U., Chuang, G. Y., Georgiev, I. S., Kong, R., O'Dell, S., Shahzad-Ul-Hussan, S., Shen, C. H., Tsybovsky, Y., Bailer, R. T., Gift, S. K., et al. A neutralizing antibody recognizing primarily N-linked glycan targets the silent face of the HIV envelope Immunity 2018 48:500-513 DOI:10.1016/j.immuni.2018.02.013 PMID:29548671
- Shivatare, S. S., Huang, L. Y., Zeng, Y. F., Liao, J. Y., You, T. H., Wang, S. Y., Cheng, T., Chiu, C. W., Chao, P., Chen, L. T., Tsai, T. I., Huang, C. C., et al. Development of glycosynthases with broad glycan specificity for the efficient glyco-remodeling of antibodies Chemical Communications 2018 54:6161-6164 DOI:10.1039/c8cc03384f PMID:29809215
- Liu, C. P., Tsai, T. I., Cheng, T., Shivatare, V. S., Wu, C. Y., Wu, C. Y., Wong, C. H. Glycoengineering of antibody (Herceptin) through yeast expression and in vitro enzymatic glycosylation Proceedings of the National Academy of Sciences of the United States of America 2018 115:720-725 DOI:10.1073/pnas.1718172115 PMID:29311294 PMCID:PMC5789950
- Cheng, C. W., Zhou, Y., Pan, W. H., Dey, S., Wu, C. Y., Hsu, W. L., Wong, C. H. Hierarchical and programmable one-pot synthesis of oligosaccharides Nature Communications 2018 9 DOI:10.1038/s41467-018-07618-8 PMID:30523255 PMCID:PMC6283847
- Dey, S., Wong, C. H. Programmable one-pot synthesis of heparin pentasaccharides enabling access to regiodefined sulfate derivatives Chemical Science 2018 9:6685-6691 DOI:10.1039/c8sc01743c
- Wang, X., Krasnova, L., Wu, K. B., Wu, W. S., Cheng, T. J., Wong, C. H. Towards new antibiotics targeting bacterial transglycosylase: Synthesis of a Lipid II analog as stable transition-state mimic inhibitor Bioorganic & Medicinal Chemistry Letters 2018 28:2708-2712 DOI:10.1016/j.bmcl.2018.03.035 PMID:29602680
- Shivatare, V. S., Shivatare, S. S., Lee, C. C. D., Liang, C. H., Liao, K. S., Cheng, Y. Y., Saidachary, G., Wu, C. Y., Lin, N. H., Kwong, P. D., Burton, D. R., Wu, C. Y., et al. Unprecedented role of hybrid N-glycans as ligands for HIV-1 broadly neutralizing antibodies Journal of the American Chemical Society 2018 140:5202-5210 DOI:10.1021/jacs.8b00896 PMID:29578688
- Shie, J. J., Liu, Y. C., Hsiao, J. C., Fang, J. M., Wong, C. H. A cell-permeable and triazole-forming fluorescent probe for glycoconjugate imaging in live cells Chemical Communications 2017 53:1490-1493 DOI:10.1039/c6cc08805h PMID:28084480
- Tsai, T. I., Li, S. T., Liu, C. P., Chen, K. Y., Shivatare, S. S., Lin, C. W., Liao, S. F., Lin, C. W., Hsu, T. L., Wu, Y. T., Tsai, M. H., Lai, M. Y., et al. An effective bacterial fucosidase for glycoprotein remodeling ACS Chemical Biology 2017 12:63-72 DOI:10.1021/acschembio.6b00821 PMID:28103685
- Andrabi, R., Su, C. Y., Liang, C. H., Shivatare, S. S., Briney, B., Voss, J. E., Nawazi, S. K., Wu, C. Y., Wong, C. H., Burton, D. R. Glycans function as anchors for antibodies and help drive HIV broadly neutralizing antibody development Immunity 2017 47:524-537 DOI:10.1016/j.immuni.2017.08.006 PMID:28916265 PMCID:PMC5613947
- Huang, Y. W., Yang, H. I., Wu, Y. T., Hsu, T. L., Lin, T. W., Kelly, J. W., Wong, C. H. Residues comprising the enhanced aromatic sequon influence protein N-glycosylation efficiency Journal of the American Chemical Society 2017 139:12947-12955 DOI:10.1021/jacs.7b03868 PMID:28820257
- Sok, D., Pauthner, M., Briney, B., Lee, J. H., Saye-Francisco, K. L., Hsueh, J., Ramos, A., Le, K. M., Jones, M., Jardine, J. G., Bastidas, R., Sarkar, A., et al. A prominent site of antibody vulnerability on HIV envelope incorporates a motif associated with CCR5 binding and its camouflaging glycans Immunity 2016 45:31-45 DOI:10.1016/j.immuni.2016.06.026 PMID:27438765 PMCID:PMC4990068
- Krasnova, L., Wong, C. H. Exploring human glycosylation for better therapies Molecular Aspects of Medicine 2016 51:125-143 DOI:10.1016/j.mam.2016.05.003 PMID:27178988
- Shivatare, S. S., Chang, S. H., Tsai, T. I., Tseng, S. Y., Shivatare, V. S., Lin, Y. S., Cheng, Y. Y., Ren, C. T., Lee, C. C. D., Pawar, S., Tsai, C. S., Shih, H. W., et al. Modular synthesis of N-glycans and arrays for the hetero-ligand binding analysis of HIV antibodies Nature Chemistry 2016 8:338-346 DOI:10.1038/nchem.2463 PMID:27001729 PMCID:PMC4806563
- Wu, T. N., Lin, K. H., Wu, Y. T., Huang, J. R., Hung, J. T., Wu, J. C., Chen, C. Y., Chu, K. C., Lin, N. H., Yu, A. L., Wong, C. H. Phenyl glycolipids with different glycosyl groups exhibit marked differences in murine and human iNKT cell activation ACS Chemical Biology 2016 11:3431-3441 DOI:10.1021/acschembio.6b00650 PMID:27782396
- Hsu, C. H., Park, S., Mortenson, D. E., Foley, B. L., Wang, X., Woods, R. J., Case, D. A., Powers, E. T., Wong, C. H., Dyson, H. J., Kelly, J. W. The dependence of carbohydrate-aromatic interaction strengths on the structure of the carbohydrate Journal of the American Chemical Society 2016 138:7636-7648 DOI:10.1021/jacs.6b02879 PMID:27249581 PMCID:PMC4924591
- Stewart-Jones, G. B. E., Soto, C., Lemmin, T., Chuang, G. Y., Druz, A., Kong, R., Thomas, P. V., Wagh, K., Zhou, T., Behrens, A. J., Bylund, T., Choi, C. W., et al. Trimeric HIV-1-Env structures define glycan shields from clades A, B, and G Cell 2016 165:813-826 DOI:10.1016/j.cell.2016.04.010 PMID:27114034
- Krasnova, L., Wong, C. H. Understanding the chemistry and biology of glycosylation with glycan synthesis Annual Review of Biochemistry 2016 85:599-630 DOI:10.1146/annurev-biochem-060614-034420 PMID:27145845
- Li, X., Kawamura, A., Andrews, C. D., Miller, J. L., Wu, D., Tsao, T., Zhang, M., Oren, D., Padte, N. N., Porcelli, S. A., Wong, C. H., Kappe, S. H. I., et al. Colocalization of a CD1d-binding glycolipid with a radiation-attenuated sporozoite vaccine in lymph node-resident dendritic cells for a robust adjuvant effect Journal of Immunology 2015 195:2710-2721 DOI:10.4049/jimmunol.1403017 PMID:26254338 PMCID:PMC4561196
- Danishefsky, S. J., Shue, Y. K., Chang, M. N., Wong, C. H. Development of globo-h cancer vaccine Accounts of Chemical Research 2015 48:643-652 DOI:10.1021/ar5004187 PMID:25665650
- Falkowska, E., Le, K. M., Ramos, A., Doores, K. J., Lee, J. H., Blattner, C., Ramirez, A., Derking, R., van Gils, M. J., Liang, C. H., McBride, R., von Bredow, B., et al. Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the prefusion conformation of gp41 on cleaved envelope trimers Immunity 2014 40:657-668 DOI:10.1016/j.immuni.2014.04.009 PMID:24768347 PMCID:PMC4070425
- Hsu, C. H., Schelwies, M., Enck, S., Huang, L. Y., Huang, S. H., Chang, Y. F., Cheng, T. J. R., Cheng, W. C., Wong, C. H. Iminosugar C-glycoside analogues of alpha-D-GlcNAc-1-Phosphate: synthesis and bacterial transglycosylase inhibition Journal of Organic Chemistry 2014 79:8629-8637 DOI:10.1021/jo501340s PMID:25137529 PMCID:PMC4168788
- Lin, J., Chang, Y., Yang, W. B., Yu, A. L., Wong, C. H. The multifaceted effects of polysaccharides isolated from Dendrobium huoshanense on immune functions with the induction of interleukin-1 receptor antagonist (IL-1ra) in monocytes PLoS One 2014 9:e94040 DOI:10.1371/journal.pone.0094040 PMID:24705413 PMCID:PMC3976396
- Huang, H. W., Chen, C. H., Lin, C. H., Wong, C. H., Lin, K. I. B-cell maturation antigen is modified by a single N-glycan chain that modulates ligand binding and surface retention Proceedings of the National Academy of Sciences of the United States of America 2013 110:10928-33 DOI:10.1073/pnas.1309417110 PMID:23776238 PMCID:PMC3704023
- Liao, S. F., Liang, C. H., Ho, M. Y., Hsu, T. L., Tsai, T. I., Hsieh, Y. S., Tsai, C. M., Li, S. T., Cheng, Y. Y., Tsao, S. M., Lin, T. Y., Lin, Z. Y., et al. Immunization of fucose-containing polysaccharides from Reishi mushroom induces antibodies to tumor-associated Globo H-series epitopes Proceedings of the National Academy of Sciences of the United States of America 2013 110:13809-14 DOI:10.1073/pnas.1312457110 PMID:23908400 PMCID:PMC3752246
- Doores, K. J., Huber, M., Le, K. M., Wang, S. K., Doyle-Cooper, C., Cooper, A., Pantophlet, R., Wong, C. H., Nemazee, D., Burton, D. R. 2G12-expressing B cell lines may aid in HIV carbohydrate vaccine design strategies Journal of Virology 2013 87:2234-2241 DOI:10.1128/jvi.02820-12 PMID:23221565 PMCID:PMC3571453
- Al-Shareffi, E., Chaubard, J. L., Leonhard-Melief, C., Wang, S. K., Wong, C. H., Haltiwanger, R. S. 6-alkynyl fucose is a bioorthogonal analog for O-fucosylation of epidermal growth factor-like repeats and thrombospondin Type-1 repeats by protein O-fucosyltransferases 1 and 2 Glycobiology 2013 23:188-198 DOI:10.1093/glycob/cws140 PMID:23045360 PMCID:PMC3531295
- Padte, N. N., Boente-Carrera, M., Andrews, C. D., McManus, J., Grasperge, B. F., Gettie, A., Coelho-dos-Reis, J. G., Li, X., Wu, D., Bruder, J. T., Sedegah, M., Patterson, N., et al. A glycolipid adjuvant, 7DW8-5, enhances CD8+T cell responses induced by an adenovirus-vectored malaria vaccine in non-human primates PLoS One 2013 8:e78407 DOI:10.1371/journal.pone.0078407 PMID:24205224 PMCID:PMC3808339
- Chen, W., Enck, S., Price, J. L., Powers, D. L., Powers, E. T., Wong, C. H., Dyson, H. J., Kelly, J. W. Structural and energetic basis of carbohydrate-aromatic packing interactions in proteins Journal of the American Chemical Society 2013 135:9877-9884 DOI:10.1021/ja4040472 PMID:23742246 PMCID:PMC3715148
- Hsu, Y., Lu, X. A., Zulueta, M. M. L., Tsai, C. M., Lin, K. I., Hung, S. C., Wong, C. H. Acyl and silyl group effects in reactivity-based one-pot glycosylation: Synthesis of embryonic stem cell surface carbohydrates lc(4) and iv(2)fuc-lc(4) Journal of the American Chemical Society 2012 134:4549-4552 DOI:10.1021/ja300284x PMID:22390569
- Zulueta, M. M. L., Lin, S. Y., Lin, Y. T., Huang, C. J., Wang, C. C., Ku, C. C., Shi, Z. H., Chyan, C. L., Irene, D., Lim, L. H., Tsai, T. I., Hu, Y. P., et al. Alpha-glycosylation by d-glucosamine-derived donors: Synthesis of heparosan and heparin analogues that interact with mycobacterial heparin-binding hemagglutinin Journal of the American Chemical Society 2012 134:8988-8995 DOI:10.1021/ja302640p PMID:22587381
- Huang, C. Y., Shih, H. W., Lin, L. Y., Tien, Y. W., Cheng, T. J. R., Cheng, W. C., Wong, C. H., Ma, C. Crystal structure of staphylococcus aureus transglycosylase in complex with a lipid ii analog and elucidation of peptidoglycan synthesis mechanism Proceedings of the National Academy of Sciences of the United States of America 2012 109:6496-6501 DOI:10.1073/pnas.1203900109 PMID:22493270 PMCID:PMC3340074
- Cheng, T. J. R., Weinheimer, S., Tarbet, E. B., Jan, J. T., Cheng, Y. S. E., Shie, J. J., Chen, C. L., Chen, C. A., Hsieh, W. C., Huang, P. W., Lin, W. H., Wang, S. Y., et al. Development of oseltamivir phosphonate congeners as anti-influenza agents Journal of Medicinal Chemistry 2012 55:8657-8670 DOI:10.1021/jm3008486 PMID:23009169 PMCID:PMC3492761
- Shih, H. W., Chang, Y. F., Li, W. J., Meng, F. C., Huang, C. Y., Ma, C., Cheng, T. J. R., Wong, C. H., Cheng, W. C. Effect of the peptide moiety of lipid ii on bacterial transglycosylase Angewandte Chemie-International Edition 2012 51:10123-10126 DOI:10.1002/anie.201204038 PMID:22952114
- Chen, S. H., Hwang, D. R., Chen, G. H., Hsu, N. S., Wu, Y. T., Li, T. L., Wong, C. H. Engineering transaldolase in Pichia stipitis to improve bioethanol production ACS Chemical Biology 2012 7:481-486 DOI:10.1021/cb200396b PMID:22148723
- Liu, K. C., Fang, J. M., Jan, J. T., Cheng, T. J. R., Wang, S. Y., Yang, S. T., Cheng, Y. S. E., Wong, C. H. Enhanced anti-influenza agents conjugated with anti-inflammatory activity Journal of Medicinal Chemistry 2012 55:8493-8501 DOI:10.1021/jm3009844 PMID:22963087
- Lenger, J., Schroder, M., Ennemann, E. C., Muller, B., Wong, C. H., Noll, T., Dierks, T., Hanson, S. R., Sewald, N. Evaluation of sulfatase-directed quinone methide traps for proteomics Bioorganic & Medicinal Chemistry 2012 20:622-627 DOI:10.1016/j.bmc.2011.04.044 PMID:21570853 PMCID:PMC3396293
- Price, J. L., Culyba, E. K., Chen, W., Murray, A. N., Hanson, S. R., Wong, C. H., Powers, E. T., Kelly, J. W. N-glycosylation of enhanced aromatic sequons to increase glycoprotein stability Biopolymers 2012 98:195-211 DOI:10.1002/bip.22030 PMID:22782562 PMCID:PMC3539202
- Hsieh, M. H., Hung, J. T., Liw, Y. W., Lu, Y. J., Wong, C. H., Yu, A. L., Liang, P. H. Synthesis and evaluation of acyl-chain- and galactose-6 ''-modified analogues of alpha-galcer for nkt cell activation ChemBioChem 2012 13:1689-1697 DOI:10.1002/cbic.201200004 PMID:22730199
- Schmaltz, R. M., Hanson, S. R., Wong, C. H. Enzymes in the synthesis of glycoconjugates Chemical Reviews 2011 111:4259-4307 DOI:10.1021/cr200113w PMID:21749134
- Shih, H. W., Chen, K. T., Cheng, T. J. R., Wong, C. H., Cheng, W. C. A new synthetic approach toward bacterial transglycosylase substrates, lipid ii and lipid iv Organic Letters 2011 13:4600-4603 DOI:10.1021/ol201806d PMID:21797279
- Pejchal, R., Doores, K. J., Walker, L. M., Khayat, R., Huang, P. S., Wang, S. K., Stanfield, R. L., Julien, J. P., Ramos, A., Crispin, M., Depetris, R., Katpally, U., et al. A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield Science 2011 334:1097-1103 DOI:10.1126/science.1213256 PMID:21998254 PMCID:PMC3280215
- Shie, J. J., Fang, J. M., Lai, P. T., Wen, W. H., Wang, S. Y., Cheng, Y. S. E., Tsai, K. C., Yang, A. S., Wong, C. H. A practical synthesis of zanamivir phosphonate congeners with potent anti-influenza activity Journal of the American Chemical Society 2011 133:17959-17965 DOI:10.1021/ja207892q PMID:21942552
- Wu, T. N., Lin, K. H., Chang, Y. J., Huang, J. R., Cheng, J. Y., Yu, A. L., Wong, C. H. Avidity of cd1d-ligand-receptor ternary complex contributes to t-helper 1 (th1) polarization and anticancer efficacy Proceedings of the National Academy of Sciences of the United States of America 2011 108:17275-17280 DOI:10.1073/pnas.1114255108 PMID:21987790 PMCID:PMC3198369
- Walker, L. M., Huber, M., Doores, K. J., Falkowska, E., Pejchal, R., Julien, J. P., Wang, S. K., Ramos, A., Chan-Hui, P. Y., Moyle, M., Mitcham, J. L., Hammond, P. W., et al. Broad neutralization coverage of HIV by multiple highly potent antibodies Nature 2011 477:466-470 DOI:10.1038/nature10373 PMID:21849977 PMCID:PMC3393110
- Chen, M. W., Liao, H. Y., Huang, Y. X., Jan, J. T., Huang, C. C., Ren, C. T., Wu, C. Y., Cheng, T. J. R., Ho, D. D., Wong, C. H. Broadly neutralizing DNA vaccine with specific mutation alters the antigenicity and sugar-binding activities of influenza hemagglutinin Proceedings of the National Academy of Sciences of the United States of America 2011 108:3510-3515 DOI:10.1073/pnas.1019744108 PMID:21321237 PMCID:PMC3048126
- Wu, C. Y., Wong, C. H. Chemistry and glycobiology Chemical Communications 2011 47:6201-6207 DOI:10.1039/c0cc04359a PMID:21503322
- Shen, Y. F., Chen, Y. H., Chu, S. Y., Lin, M. I., Hsu, H. T., Wu, P. Y., Wu, C. J., Liu, H. W., Lin, F. Y., Lin, G., Hsu, P. H., Yang, A. S., et al. E339 ... R416 salt bridge of nucleoprotein as a feasible target for influenza virus inhibitors Proceedings of the National Academy of Sciences of the United States of America 2011 108:16515-16520 DOI:10.1073/pnas.1113107108 PMID:21930946 PMCID:PMC3189076
- Liang, C. H., Wang, S. K., Lin, C. W., Wang, C. C., Wong, C. H., Wu, C. Y. Effects of neighboring glycans on antibody-carbohydrate interaction Angewandte Chemie-International Edition 2011 50:1608-1612 DOI:10.1002/anie.201003482 PMID:21308915
- Chu, K. C., Ren, C. T., Lu, C. P., Hsu, C. H., Sun, T. H., Han, J. L., Pal, B., Chao, T. A., Lin, Y. F., Wu, S. H., Wong, C. H., Wu, C. Y. Efficient and stereoselective synthesis of alpha(2 -> 9) oligosialic acids: From monomers to dodecamers Angewandte Chemie-International Edition 2011 50:9391-9395 DOI:10.1002/anie.201101794 PMID:21948436
- Hsu, J. W., Huang, H. C., Chen, S. T., Wong, C. H., Juan, H. F. Ganoderma lucidum polysaccharides induce macrophage-like differentiation in human leukemia thp-1 cells via caspase and p53 activation Evidence-Based Complementary and Alternative Medicine 2011 1-13 DOI:10.1093/ecam/nep107 PMID:19696196 PMCID:PMC3135330
- Yen, H. L., Liang, C. H., Wu, C. Y., Forrest, H. L., Ferguson, A., Choy, K. T., Jones, J., Wong, D. D. Y., Cheung, P. P. H., Hsu, C. H., Li, O. T., Yuen, K. M., et al. Hemagglutinin-neuraminidase balance confers respiratory-droplet transmissibility of the pandemic h1n1 influenza virus in ferrets Proceedings of the National Academy of Sciences of the United States of America 2011 108:14264-14269 DOI:10.1073/pnas.1111000108 PMID:21825167 PMCID:PMC3161546
- Punyadarsaniya, D., Liang, C. H., Winter, C., Petersen, H., Rautenschlein, S., Hennig-Pauka, I., Schwegmann-Wessels, C., Wu, C. Y., Wong, C. H., Herrler, G. Infection of differentiated porcine airway epithelial cells by influenza virus: Differential susceptibility to infection by porcine and avian viruses PLoS One 2011 6:e28429 DOI:10.1371/journal.pone.0028429 PMID:22174804 PMCID:PMC3235120
- Liu, K. C., Lee, P. S., Wang, S. Y., Cheng, Y. S. E., Fang, J. M., Wong, C. H. Intramolecular ion-pair prodrugs of zanamivir and guanidino-oseltamivir Bioorganic & Medicinal Chemistry 2011 19:4796-4802 DOI:10.1016/j.bmc.2011.06.080 PMID:21778065
- Kinjo, Y., Illarionov, P., Vela, J. L., Pei, B., Girardi, E., Li, X. M., Li, Y. L., Imamura, M., Kaneko, Y., Okawara, A., Miyazaki, Y., Gomez-Velasco, A., et al. Invariant natural killer t cells recognize glycolipids from pathogenic gram-positive bacteria Nature Immunology 2011 12:966-974 DOI:10.1038/ni.2096 PMID:21892173 PMCID:PMC3178673
- Chou, C. Y., Ko, T. P., Wu, K. J., Huang, K. F., Wong, C. H., Wang, A. H. J., Lin, C. H. Modulation of substrate specificities of D-sialic acid aldolase through single mutations of Val-251 Journal of Biological Chemistry 2011 286:14057-14064 DOI:10.1074/jbc.M110.179465 PMID:21270125 PMCID:PMC3077606
- Tsai, B. L., Han, J. L., Ren, C. T., Wu, C. Y., Wong, C. H. Programmable one-pot synthesis of tumor-associated carbohydrate antigens lewis x dimer and kh-1 epitopes Tetrahedron Letters 2011 52:2132-2135 DOI:10.1016/j.tetlet.2010.11.055
- Culyba, E. K., Price, J. L., Hanson, S. R., Dhar, A., Wong, C. H., Gruebele, M., Powers, E. T., Kelly, J. W. Protein native-state stabilization by placing aromatic side chains in N-glycosylated reverse turns Science 2011 331:571-575 DOI:10.1126/science.1198461 PMID:21292975 PMCID:PMC3099596
- Chang, C. F., Pan, J. F., Wu, I. L., Wong, C. H., Lin, C. H. Rapid characterization of sugar-binding specificity by in-solution proximity binding with photosensitizers Glycobiology 2011 21:895-902 DOI:10.1093/glycob/cwr021 PMID:21325337
- Liu, Y. C., Yen, H. Y., Chen, C. Y., Chen, C. H., Cheng, P. F., Juan, Y. H., Khoo, K. H., Yu, C. J., Yang, P. C., Hsu, T. L., Wong, C. H. Sialylation and fucosylation of epidermal growth factor receptor suppress its dimerization and activation in lung cancer cells Proceedings of the National Academy of Sciences of the United States of America 2011 108:11332-11337 DOI:10.1073/pnas.1107385108 PMID:21709263 PMCID:PMC3136320
- Lee, R. T., Hsu, T. L., Huang, S. K., Hsieh, S. L., Wong, C. H., Lee, Y. C. Survey of immune-related, mannose/fucose-binding c-type lectin receptors reveals widely divergent sugar-binding specificities Glycobiology 2011 21:512-520 DOI:10.1093/glycob/cwq193 PMID:21112966 PMCID:PMC3055596
- Meng, F. C., Chen, K. T., Huang, L. Y., Shih, H. W., Chang, H. H., Nien, F. Y., Liang, P. H., Cheng, T. J. R., Wong, C. H., Cheng, W. C. Total synthesis of polyprenyl n-glycolyl lipid ii as a mycobacterial transglycosylase substrate Organic Letters 2011 13:5306-5309 DOI:10.1021/ol2021687 PMID:21913698
- Hsu, C. H., Hung, S. C., Wu, C. Y., Wong, C. H. Toward automated oligosaccharide synthesis Angewandte Chemie-International Edition 2011 50:11872-11923 DOI:10.1002/anie.201100125 PMID:22127846
- Chen, J. R., Ma, C., Wong, C. H. Vaccine design of hemagglutinin glycoprotein against influenza Trends in Biotechnology 2011 29:426-434 DOI:10.1016/j.tibtech.2011.04.007 PMID:21640418
- Chang, C. C., Ku, A. F., Tseng, Y. Y., Yang, W. B., Fang, J. M., Wong, C. H. 6,8-di-C-glycosyl flavonoids from Dendrobium huoshanense Journal of Natural Products 2010 73:229-232 DOI:10.1021/np900252f PMID:20055483
- Payne, R. J., Wong, C. H. Advances in chemical ligation strategies for the synthesis of glycopeptides and glycoproteins Chemical Communications 2010 46:21-43 DOI:10.1039/b913845e PMID:20024291
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- Tsai, C. Y., Huang, X. F., Wong, C. H. Design and synthesis of cyclic sialyl lewis x mimetics: A remarkable enhancement of inhibition by pre-organizing all essential functional groups Tetrahedron Letters 2000 41:9499-9503 DOI:10.1016/s0040-4039(00)01653-1
- Sucheck, S. J., Wong, A. L., Koeller, K. M., Boehr, D. D., Draker, K., Sears, P., Wright, G. D., Wong, C. H. Design of bifunctional antibiotics that target bacterial rRNA and inhibit resistance-causing enzymes Journal of the American Chemical Society 2000 122:5230-5231 DOI:10.1021/ja000575w
- Sucheck, S. J., Greenberg, W. A., Tolbert, T. J., Wong, C. H. Design of small molecules that recognize rna: Development of aminoglycosides as potential antitumor agents that target oncogenic rna sequences Angewandte Chemie-International Edition 2000 39:1080-1084 DOI:10.1002/(sici)1521-3773(20000317)39:6<1080::aid-anie1080>3.0.co;2-b PMID:10760928
- Fong, S., Machajewski, T. D., Mak, C. C., Wong, C. H. Directed evolution of d-2-keto-3-deoxy-6-phosphogluconate aldolase to new variants for the efficient synthesis of d- and l-sugars Chemistry & Biology 2000 7:873-883 DOI:10.1016/s1074-5521(00)00035-1 PMID:11094340
- Flessner, T., Wong, C. H. Efficient synthesis of triazoles from d-arabinose and l-fucose Tetrahedron Letters 2000 41:7805-7808 DOI:10.1016/s0040-4039(00)01356-3
- Koeller, K. M., Wong, C. H. Emerging themes in medicinal glycoscience Nature Biotechnology 2000 18:835-841 PMID:10932151
- Tolbert, T. J., Wong, C. H. Intein-mediated synthesis of proteins containing carbohydrates and other molecular probes Journal of the American Chemical Society 2000 122:5421-5428 DOI:10.1021/ja0000192
- Sheppard, T. L., Wong, C. H., Joyce, G. F. Nucleoglycoconjugates: Design and synthesis of a new class of DNA-carbohydrate conjugates Angewandte Chemie-International Edition 2000 39:3660-3663 DOI:10.1002/1521-3773(20001016)39:20<3660::aid-anie3660>3.0.co;2-l PMID:11091431
- Burkart, M. D., Izumi, M., Chapman, E., Lin, C. H., Wong, C. H. Regeneration of PAPS for the enzymatic synthesis of sulfated oligosaccharides Journal of Organic Chemistry 2000 65:5565-5574 DOI:10.1021/jo000266o PMID:10970295
- Kanie, O., Grotenbreg, G., Wong, C. H. Removal of benzyl protecting groups from solid-supported compounds by hydrogenolysis using palladium nanoparticles Angewandte Chemie-International Edition 2000 39:4545-4547 DOI:10.1002/1521-3773(20001215)39:24<4545::aid-anie4545>3.3.co;2-m PMID:11169665
- Sucheck, S. J., Wong, C. H. Rna as a target for small molecules Current Opinion in Chemical Biology 2000 4:678-686 DOI:10.1016/s1367-5931(00)00142-3 PMID:11102874
- Li, M., Morris, G. M., Lee, T., Laco, G. S., Wong, C. H., Olson, A. J., Elder, J. H., Wlodawer, A., Gustchina, A. Structural studies of FIV and HIV-1 proteases complexed with all efficient inhibitor of FIV protease Proteins-Structure Function and Genetics 2000 38:29-40 DOI:10.1002/(sici)1097-0134(20000101)38:1<29::aid-prot4>3.0.co;2-n PMID:10651036
- Sun, X. L., Kanie, Y., Guo, C. T., Kanie, O., Suzuki, Y., Wong, C. H. Syntheses of c-3-modified sialylglycosides as selective inhibitors of influenza hemagglutinin and neuraminidase European Journal of Organic Chemistry 2000 2643-2653
- Shibata, K., Hiruma, K., Kanie, O., Wong, C. H. Synthesis of 1,1-linked galactosyl mannosides carrying a thiazine ring as mimetics of sialyl lewis x antigen: Investigation of the effect of carboxyl group orientation on p-selectin inhibition Journal of Organic Chemistry 2000 65:2393-2398 DOI:10.1021/jo991556b PMID:10789451
- Le, V. D., Wong, C. H. Synthesis of 2-substituted polyhydroxytetrahydropyrimidines (n-hydroxy cyclic guanidino-sugars): Transition state mimics of enzymatic glycosidic cleavage Journal of Organic Chemistry 2000 65:2399-2409 DOI:10.1021/jo9915574 PMID:10789452
- Koeller, K. M., Wong, C. H. Synthesis of complex carbohydrates and glycoconjugates: Enzyme-based and programmable one-pot strategies Chemical Reviews 2000 100:4465-4493 DOI:10.1021/cr990297n PMID:11749355
- Machajewski, T. D., Wong, C. H. The catalytic asymmetric aldol reaction Angewandte Chemie-International Edition 2000 39:1352-1374 DOI:10.1002/(sici)1521-3773(20000417)39:8<1352::aid-anie1352>3.0.co;2-j PMID:10777624
- Koeller, K. M., Smith, M. E. B., Wong, C. H. Tyrosine sulfation on a psgl-1 glycopeptide influences the reactivity of glycosyltransferases responsible for synthesis of the attached o-glycan Journal of the American Chemical Society 2000 122:742-743 DOI:10.1021/ja993820o
- Burkart, M. D., Wong, C. H. A continuous assay for the spectrophotometric analysis of sulfotransferases using aryl sulfotransferase iv Analytical Biochemistry 1999 274:131-137 DOI:10.1006/abio.1999.4264 PMID:10527506
- Takebayashi, M., Hiranuma, S., Kanie, Y., Kajimoto, T., Kanie, O., Wong, C. H. A versatile synthetic strategy for the preparation and discovery of new iminocyclitols as inhibitors of glycosidases Journal of Organic Chemistry 1999 64:5280-5291 DOI:10.1021/jo9902446
- Burkart, M. D., Vincent, S. P., Wong, C. H. An efficient synthesis of cmp-3-fluoroneuraminic acid Chemical Communications 1999 1525-1526 DOI:10.1039/a903362i
- Kidd, R. D., Sears, P., Huang, D. H., Witte, K., Wong, C. H., Farber, G. K. Breaking the low barrier hydrogen bond in a serine protease Protein Science 1999 8:410-417 DOI:10.1110/ps.8.2.410 PMID:10048334 PMCID:PMC2144249
- Sears, P., Wong, C. H. Carbohydrate mimetics: a new strategy for tackling the problem of carbohydrate-mediated biological recognition Angewandte Chemie-International Edition 1999 38:2300-2324 DOI:10.1002/(SICI)1521-3773(19990816)38:16<2300::AID-ANIE2300>3.0.CO;2-6 PMID:10458780
- Machajewski, T. D., Wong, C. H. Chemoenzymatic synthesis of key epothilone fragments Synthesis-Stuttgart 1999 1469-1472
- Wong, C. H. Design and synthesis of carbohydrate mimetics: A new strategy for tackling the problem of carbohydrate-mediated biological recognition Journal of the Chinese Chemical Society 1999 46:271-281
- Greenberg, W. A., Priestley, E. S., Sears, P. S., Alper, P. B., Rosenbohm, C., Hendrix, M., Hung, S. C., Wong, C. H. Design and synthesis of new aminoglycoside antibiotics containing neamine as an optimal core structure: Correlation of antibiotic activity with in vitro inhibition of translation Journal of the American Chemical Society 1999 121:6527-6541 DOI:10.1021/ja9910356
- Huwe, C. M., Woltering, T. J., Jiricek, J., Weitz-Schmidt, G., Wong, C. H. Design, synthesis and biological evaluation of aryl-substituted sialyl lewis x mimetics prepared via cross-metathesis of c-fucopeptides Bioorganic & Medicinal Chemistry 1999 7:773-788 DOI:10.1016/s0968-0896(98)00245-4 PMID:10400330
- Takayama, S., Lee, S. T., Hung, S. C., Wong, C. H. Designing enzymatic resolution of amines Chemical Communications 1999 127-128 DOI:10.1039/a808028c
- Lee, T. Y., Le, V. D., Lim, D. Y., Lin, Y. C., Morris, G. M., Wong, A. L., Olson, A. J., Elder, J. H., Wong, C. H. Development of a new type of protease inhibitors, efficacious against FIV and HIV variants Journal of the American Chemical Society 1999 121:1145-1155 DOI:10.1021/ja982893p
- Vincent, S. P., Burkart, M. D., Tsai, C. Y., Zhang, Z. Y., Wong, C. H. Electrophilic fluorination-nucleophilic addition reaction mediated by selectfluor: Mechanistic studies and new applications Journal of Organic Chemistry 1999 64:5264-5279 DOI:10.1021/jo990686h
- Burkart, M. D., Izumi, M., Wong, C. H. Enzymatic regeneration of 3 '-phosphoadenosine-5 '-phosphosulfate using aryl sulfotransferase for the preparative enzymatic synthesis of sulfated carbohydrates Angewandte Chemie-International Edition 1999 38:2747-2750 DOI:10.1002/(sici)1521-3773(19990917)38:18<2747::aid-anie2747>3.0.co;2-2 PMID:10508369
- Shen, G. J., Datta, A. K., Izumi, M., Koeller, K. M., Wong, C. H. Expression of α2,8/2,9-polysialyltransferase from escherichia coli K92 - characterization of the enzyme and its reaction products Journal of Biological Chemistry 1999 274:35139-35146 DOI:10.1074/jbc.274.49.35139 PMID:10574996
- Hiranuma, S., Kanie, O., Wong, C. H. Formation of the 1,2,6-orthoester of mannose and its utilization in the glycosylation reaction Tetrahedron Letters 1999 40:6423-6426 DOI:10.1016/s0040-4039(99)01193-4
- Wong, C. H. Mimics of complex carbohydrates recognized by receptors Accounts of Chemical Research 1999 32:376-385 DOI:10.1021/ar960237t
- Mao, S. L., Gao, C., Lo, C. H. L., Wirsching, P., Wong, C. H., Janda, K. D. Phage-display library selection of high-affinity human single-chain antibodies to tumor-associated carbohydrate antigens sialyl Lewis(x) and Lewis(x) Proceedings of the National Academy of Sciences of the United States of America 1999 96:6953-6958 DOI:10.1073/pnas.96.12.6953 PMID:10359820
- Zhang, Z. Y., Ollmann, I. R., Ye, X. S., Wischnat, R., Baasov, T., Wong, C. H. Programmable one-pot oligosaccharide synthesis Journal of the American Chemical Society 1999 121:734-753 DOI:10.1021/ja982232s
- Weitz-Schmidt, G., Gong, K. W., Wong, C. H. Selectin/glycoconjugate binding assays for the identification and optimization of selectin antagonists Analytical Biochemistry 1999 273:81-88 DOI:10.1006/abio.1999.4180 PMID:10452802
- Takayama, S., Chung, S. J., Igarashi, Y., Ichikawa, Y., Sepp, A., Lechler, R. I., Wu, J., Hayashi, T., Siuzdak, G., Wong, C. H. Selective inhibition of β-1,4- and α-1,3-galactosyltransferases: donor sugar-nucleotide based approach Bioorganic & Medicinal Chemistry 1999 7:401-409 DOI:10.1016/s0968-0896(98)00249-1 PMID:10218835
- Wu, W. G., Pasternack, L., Huang, D. H., Koeller, K. M., Lin, C. C., Seitz, O., Wong, C. H. Structural study on O-glycopeptides: Glycosylation-induced conformational changes of O-GlcNAc, O-LacNAc, O-Sialyl-LacNAc, and O-Sialyl-Lewis-X peptides of the mucin domain of madcam-1 Journal of the American Chemical Society 1999 121:2409-2417 DOI:10.1021/ja983474v
- Yuasa, H., Hashimoto, H., Abe, Y., Kajimoto, T., Wong, C. H. Studies on the unusual stability of cis-2,5-diethoxy-2,5-bis(hydroxymethyl)-1,4-dioxane Tetrahedron 1999 55:2193-2204 DOI:10.1016/s0040-4020(99)00003-4
- Koeller, K. M., Wong, C. H. Synthesis of biologically active glycopeptides Journal of the Chinese Chemical Society 1999 46:659-685
- Depre, D., Duffels, A., Green, L. G., Lenz, R., Ley, S. V., Wong, C. H. Synthesis of glycans from the glycodelins: Two undeca-, two deca-, three nona-, an octa- and a heptasaccharide Chemistry-a European Journal 1999 5:3326-3340 DOI:10.1002/(sici)1521-3765(19991105)5:11<3326::aid-chem3326>3.0.co;2-q
- Lin, C. C., Moris-Varas, F., Weitz-Schmidt, G., Wong, C. H. Synthesis of sialyl Lewis x mimetics as selectin inhibitors by enzymatic aldol condensation reactions Bioorganic & Medicinal Chemistry 1999 7:425-433 DOI:10.1016/s0968-0896(98)00242-9 PMID:10220028
- Sears, P., Witte, K., Wong, C. H. The effect of counterion, water concentration, and stirring on the stability of subtilisin BPN′ in organic solvents Journal of Molecular Catalysis B-Enzymatic 1999 6:297-304 DOI:10.1016/s1381-1177(98)00085-x
- Zhang, X. D., Rosenthal, P. B., Formanowski, F., Fitz, W., Wong, C. H., Meier-Ewert, H., Skehel, J. J., Wiley, D. C. X-ray crystallographic determination of the structure of the influenza c virus haemagglutinin-esterase-fusion glycoprotein Acta Crystallographica Section D-Biological Crystallography 1999 55:945-961 DOI:10.1107/s0907444999000232 PMID:10216291
- Wong, C. H.*, Hendrix, M.*, Manning, D. D., Rosenbohm, C., Greenberg, W. A. A library approach to the discovery of small molecules that recognize rna: Use of a 1,3-hydroxyamine motif as core Journal of the American Chemical Society 1998 120:8319-8327 DOI:10.1021/ja980826p (* = equal contribution)
- Kamitakahara, H., Suzuki, T., Nishigori, N., Suzuki, Y., Kanie, O., Wong, C. H. A lysoganglioside poly-l-glutamic acid conjugate as a picomolar inhibitor of influenza hemagglutinin Angewandte Chemie-International Edition 1998 37:1524-1528 DOI:10.1002/(sici)1521-3773(19980619)37:11<1524::aid-anie1524>3.3.co;2-4
- Witte, K., Skolnick, J., Wong, C. H. A synthetic retrotransition (backward reading) sequence of the right-handed three-helix bundle domain (10-53) of protein a shows similarity in conformation as predicted by computation Journal of the American Chemical Society 1998 120:13042-13045 DOI:10.1021/ja982203h
- Chung, S. J., Takayama, S., Wong, C. H. Acceptor substrate-based selective inhibition of galactosyltransferases Bioorganic & Medicinal Chemistry Letters 1998 8:3359-3364 DOI:10.1016/s0960-894x(98)00618-0 PMID:9873734
- Lee, T., Laco, G. S., Torbett, B. E., Fox, H. S., Lerner, D. L., Elder, J. H., Wong, C. H. Analysis of the S3 and S3' subsite specificities of feline immunodeficiency virus (FIV) protease: development of a broad-based protease inhibitor efficacious against FIV, SIV, and HIV in vitro and ex vivo Proceedings of the National Academy of Sciences of the United States of America 1998 95:939-944 DOI:10.1073/pnas.95.3.939 PMID:9448264 PMCID:PMC18632
- Wong, C. H., Ye, X. S., Zhang, Z. Y. Assembly of oligosaccharide libraries with a designed building block and an efficient orthogonal protection-deprotection strategy Journal of the American Chemical Society 1998 120:7137-7138 DOI:10.1021/ja9813616
- Wischnat, R., Martin, R., Takayama, S., Wong, C. H. Chemoenzymatic synthesis of iminocyclitol derivatives: A useful library strategy for the development of selective fucosyltransfer enzymes inhibitors Bioorganic & Medicinal Chemistry Letters 1998 8:3353-3358 DOI:10.1016/s0960-894x(98)00617-9 PMID:9873733
- Kanie, Y., Kirsch, A., Kanie, O., Wong, C. H. Enzymatic assay of galactosyltransferase by capillary electrophoresis Analytical Biochemistry 1998 263:240-245 DOI:10.1006/abio.1998.2762 PMID:9799537
- Vassilev, V. P., Simanek, E. E., Wood, M. R., Wong, C. H. Enzymatic synthesis of a chiral gelator with remarkably low molecular weight Chemical Communications 1998 1865-1866 DOI:10.1039/a803230k
- Sears, P., Wong, C. H. Enzyme action in glycoprotein synthesis Cellular and Molecular Life Sciences 1998 54:223-252 DOI:10.1007/s000180050146 PMID:9575336
- Simanek, E. E., Huang, D. H., Pasternack, L., Machajewski, T. D., Seitz, O., Millar, D. S., Dyson, H. J., Wong, C. H. Glycosylation of threonine of the repeating unit of RNA polymerase II with beta-linked N-acetylglucosame leads to a turnlike structure Journal of the American Chemical Society 1998 120:11567-11575 DOI:10.1021/ja982312w
- Wittmann, V., Takayama, S., Gong, K. W., Weitz-Schmidt, G., Wong, C. H. Ligand recognition by E- and P-selectin: Chemoenzymatic synthesis and inhibitory activity of bivalent sialyl Lewis x derivatives and sialyl Lewis x carboxylic acids Journal of Organic Chemistry 1998 63:5137-5143 DOI:10.1021/jo980350s
- Sears, P., Wong, C. H. Mechanism-based inhibition of carbohydrate-mediated biological recognitions Chemical Communications 1998 1161-1170 DOI:10.1039/a800838h
- Lampe, T. F. J., Weitz-Schmidt, G., Wong, C. H. Parallel synthesis of sialyl lewis x mimetics on a solid phase: Access to a library of fucopeptides Angewandte Chemie-International Edition 1998 37:1707-1711 DOI:10.1002/(sici)1521-3773(19980703)37:12<1707::aid-anie1707>3.3.co;2-m
- Hogg, J. H., Ollmann, I. R., Wetterholm, A., Andberg, M. B., Haeggstrom, J., Samuelsson, B., Wong, C. H. Probing the activities and mechanisms of leukotriene a(4) hydrolase with synthetic inhibitors Chemistry-a European Journal 1998 4:1698-1713 DOI:10.1002/(sici)1521-3765(19980904)4:9<1698::aid-chem1698>3.3.co;2-a
- Alper, P. B., Hendrix, M., Sears, P., Wong, C. H. Probing the specificity of aminoglycoside ribosomal rna interactions with designed synthetic analogs Journal of the American Chemical Society 1998 120:1965-1978 DOI:10.1021/ja972599h
- Kanemitsu, T., Kanie, O., Wong, C. H. Quantitative monitoring of solid-phase synthesis using gated decoupling c-13 NMR spectroscopy with a c-13-enriched protecting group and an internal standard in the synthesis of sialyl lewis(x) tetrasaccharide Angewandte Chemie-International Edition 1998 37:3415-3418 DOI:10.1002/(sici)1521-3773(19981231)37:24<3415::aid-anie3415>3.0.co;2-8
- Simanek, E. E., McGarvey, G. J., Jablonowski, J. A., Wong, C. H. Selectin-carbohydrate interactions: From natural ligands to designed mimics Chemical Reviews 1998 98:833-862 DOI:10.1021/cr940226i PMID:11848916
- Witte, K., Seitz, O., Wong, C. H. Solution- and solid-phase synthesis of n-protected glycopeptide esters of the benzyl type as substrates for subtilisin-catalyzed glycopeptide couplings Journal of the American Chemical Society 1998 120:1979-1989 DOI:10.1021/ja9736727
- Wong, C. H.*, Hendrix, M.*, Priestley, E. S., Greenberg, W. A. Specificity of aminoglycoside antibiotics for the a-site of the decoding region of ribosomal rna Chemistry & Biology 1998 5:397-406 DOI:10.1016/s1074-5521(98)90073-4 PMID:9662506 (* = equal contribution)
- Rosenthal, P. B., Zhang, X. D., Formanowski, F., Fitz, W., Wong, C. H., Meier-Ewert, H., Skehel, J. J., Wiley, D. C. Structure of the haemagglutinin-esterase-fusion glycoprotein of influenza c virus Nature 1998 396:92-96 PMID:9817207
- Miura, T., Kajimoto, T., Jimbo, M., Yamagishi, K., Inokuchi, J. C., Wong, C. H. Synthesis and evaluation of morpholino- and pyrrolidinosphingolipids as inhibitors of glucosylceramide synthase Bioorganic & Medicinal Chemistry 1998 6:1481-1489 DOI:10.1016/s0968-0896(98)00077-7 PMID:9801819
- Wischnat, R., Martin, R., Wong, C. H. Synthesis of a new class of n-linked lewis and lacnac analogues as potential inhibitors of human fucosyltransferases: A general method for the incorporation of an iminocyclitol as a transition-state mimetic of the donor sugar to the acceptor Journal of Organic Chemistry 1998 63:8361-8365 DOI:10.1021/jo981245l
- Hiruma, K., Kanie, O., Wong, C. H. Synthesis of analogs of 1,1-linked galactosyl mannoside as mimetics of sialyl lewis x tetrasaccharide Tetrahedron 1998 54:15781-15792 DOI:10.1016/s0040-4020(98)00990-9
- Tsai, C. Y., Park, W. K. C., Weitz-Schmidt, G., Ernst, B., Wong, C. H. Synthesis of sialyl lewis x mimetics using the ugi four-component reaction Bioorganic & Medicinal Chemistry Letters 1998 8:2333-2338 DOI:10.1016/s0960-894x(98)00422-3 PMID:9873537
- Guo, C. T., Wong, C. H., Kajimoto, T., Miura, T., Ida, Y., Juneja, L. R., Kim, M. J., Masuda, H., Suzuki, T., Suzuki, Y. Synthetic sialylphosphatidylethanolamine derivatives bind to human influenza a viruses and inhibit viral infection Glycoconjugate Journal 1998 15:1099-1108 DOI:10.1023/a:1006961912465 PMID:10386895
- Anderson, C. M., Mandell, A. J., Selz, K. A., Terry, L. M., Wong, C. H., Robinson, S. R., Robertson, S. S., Smotherman, W. P. The development of nuchal atonia associated with active (rem) sleep in fetal sheep: Presence of recurrent fractal organization Brain Research 1998 787:351-357 DOI:10.1016/s0006-8993(98)00008-0 PMID:9518691
- Martin, R., Witte, K. L., Wong, C. H. The synthesis and enzymatic incorporation of sialic acid derivatives for use as tools to study the structure, activity, and inhibition of glycoproteins and other glycoconjugates Bioorganic & Medicinal Chemistry 1998 6:1283-1292 DOI:10.1016/s0968-0896(98)00121-7 PMID:9784869
- Wittmann, V., Wong, C. H. 1H-tetrazole as catalyst in phosphomorpholidate coupling reactions: efficient synthesis of GDP-fucose, GDP-mannose, and UDP-galactose Journal of Organic Chemistry 1997 62:2144-2147 DOI:10.1021/jo9620066 PMID:11671520
- Wong, C. H. A chemo-enzymatic approach to the study of carbohydrate-based biological recognitions Pure and Applied Chemistry 1997 69:419-422 DOI:10.1351/pac199769030419
- Hayashi, T., Murray, B. W., Wang, R., Wong, C. H. A chemoenzymatic synthesis of UDP-(2-deoxy-2-fluoro)-galactose and evaluation of its interaction with galactosyltransferase Bioorganic & Medicinal Chemistry 1997 5:497-500 DOI:10.1016/s0968-0896(96)00263-5 PMID:9113327
- Burkart, M. D., Zhang, Z. Y., Hung, S. C., Wong, C. H. A new method for the synthesis of fluoro-carbohydrates and glycosides using selectfluor Journal of the American Chemical Society 1997 119:11743-11746 DOI:10.1021/ja9723904
- Wang, R., Steensma, D. H., Takaoka, Y., Yun, J. W., Kajimoto, T., Wong, C. H. A search for pyrophosphate mimics for the development of substrates and inhibitors of glycosyltransferases Bioorganic & Medicinal Chemistry 1997 5:661-672 DOI:10.1016/s0968-0896(97)00005-9 PMID:9158864
- Janda, K. D., Lo, L. C., Lo, C. H. L., Sim, M. M., Wang, R., Wong, C. H., Lerner, R. A. Chemical selection for catalysis in combinatorial antibody libraries Science 1997 275:945-948 DOI:10.1126/science.275.5302.945 PMID:9020070
- McGarvey, G. J., Wong, C. H. Chemical, enzymatic and structural studies in molecular glycobiology Liebigs Annalen-Recueil 1997 1059-1074
- Takayama, S., Wong, C. H. Chemo-enzymatic approach to carbohydrate recognition Current Organic Chemistry 1997 1:109-126
- Takayama, S., Martin, R., Wu, J., Laslo, K., Siuzdak, G., Wong, C. H. Chemoenzymatic preparation of novel cyclic imine sugars and rapid biological activity evaluation using electrospray mass spectrometry and kinetic analysis Journal of the American Chemical Society 1997 119:8146-8151 DOI:10.1021/ja971695f
- Seitz, O., Wong, C. H. Chemoenzymatic solution- and solid-phase synthesis of o-glycopeptides of the mucin domain of madcam-1. A general route to o-lacnac, o-sialyl-lacnac, and o-sialyl-lewis-x peptides Journal of the American Chemical Society 1997 119:8766-8776 DOI:10.1021/ja971383c
- Ikeda, T., Kajimoto, T., Kondo, H., Wong, C. H. Design and synthesis of an alpha-mannosyl terpenoid as selective inhibitor of p-selectin Bioorganic & Medicinal Chemistry Letters 1997 7:2485-2490 DOI:10.1016/s0960-894x(97)10022-1
- Hendrix, M., Priestley, E. S., Joyce, G. F., Wong, C. H. Direct observation of aminoglycoside-RNA interactions by surface plasmon resonance Journal of the American Chemical Society 1997 119:3641-3648 DOI:10.1021/ja964290o PMID:11540136
- Witte, K., Sears, P., Martin, R., Wong, C. H. Enzymatic glycoprotein synthesis: Preparation of ribonuclease glycoforms via enzymatic glycopeptide condensation and glycosylation Journal of the American Chemical Society 1997 119:2114-2118 DOI:10.1021/ja961846z
- Kim, M. J., Lim, I. T., Kim, H. J., Wong, C. H. Enzymatic single aldol reactions of remote dialdehydes Tetrahedron-Asymmetry 1997 8:1507-1509 DOI:10.1016/s0957-4166(97)00139-0
- Kimura, T., Vassilev, V. P., Shen, G. J., Wong, C. H. Enzymatic synthesis of beta-hydroxy-alpha-amino acids based on recombinant d- and l-threonine aldolases Journal of the American Chemical Society 1997 119:11734-11742 DOI:10.1021/ja9720422
- Takayama, S., McGarvey, G. J., Wong, C. H. Enzymes in organic synthesis: Recent developments in aldol reactions and glycosylations Chemical Society Reviews 1997 26:407-415 DOI:10.1039/cs9972600407
- Moree, W. J., Sears, P., Kawashiro, K., Witte, K., Wong, C. H. Exploitation of subtilisin bpn' as catalyst for the synthesis of peptides containing noncoded amino acids, peptide mimetics and peptide conjugates Journal of the American Chemical Society 1997 119:3942-3947 DOI:10.1021/ja964399w
- Hendrix, M., Alper, P. B., Priestley, E. S., Wong, C. H. Hydroxyamines as a new motif for the molecular recognition of phosphodiesters: Implications for aminoglycoside-rna interactions Angewandte Chemie-International Edition 1997 36:95-98 DOI:10.1002/anie.199700951
- Murray, B. W., Wittmann, V., Burkart, M. D., Hung, S. C., Wong, C. H. Mechanism of human alpha-1,3-fucosyltransferase v: Glycosidic cleavage occurs prior to nucleophilic attack Biochemistry 1997 36:823-831 DOI:10.1021/bi962284z PMID:9020780
- Takayama, S., McGarvey, G. J., Wong, C. H. Microbial aldolases and transketolases: New biocatalytic approaches to simple and complex sugars Annual Review of Microbiology 1997 51:285-310 DOI:10.1146/annurev.micro.51.1.285 PMID:9343352
- Hung, S. C., Lin, C. C., Wong, C. H. One-pot synthesis of 1-allyl- and 1-allenyl-6-O-acetyl-2,3,4-tri-O-benzyl-α-D-glycosides from methyl tetra-O-benzyl-α-D-glycosides Tetrahedron Letters 1997 38:5419-5422 DOI:10.1016/s0040-4039(97)01204-5
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- Sears, P., Wong, C. H. Engineering enzymes for bioorganic synthesis: Peptide bond formation Biotechnology Progress 1996 12:423-433 DOI:10.1021/bp9500730
- Takayama, S., Moree, W. J., Wong, C. H. Enzymatic resolution of amines and amino alcohols using pent-4-enoyl derivatives Tetrahedron Letters 1996 37:6287-6290 DOI:10.1016/0040-4039(96)01378-0
- MorisVaras, F., Qian, X. H., Wong, C. H. Enzymatic/chemical synthesis and biological evaluation of seven-membered iminocyclitols Journal of the American Chemical Society 1996 118:7647-7652 DOI:10.1021/ja960975c
- Orsat, B., Alper, P. B., Moree, W., Mak, C. P., Wong, C. H. Homocarbonates as substrates for the enantioselective enzymatic protection of amines Journal of the American Chemical Society 1996 118:712-713 DOI:10.1021/ja9533048
- Patterson, J. E., Ollmann, I. R., Cravatt, B. F., Boger, D. L., Wong, C. H., Lerner, R. A. Inhibition of oleamide hydrolase catalyzed hydrolysis of the endogenous sleep-inducing lipid cis-9-octadecenamide Journal of the American Chemical Society 1996 118:5938-5945 DOI:10.1021/ja954064z
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- Shibata, K., Shingu, K., Vassilev, V. P., Nishide, K., Fujita, T., Node, M., Kajimoto, T., Wong, C. H. Kinetic and thermodynamic control of l-threonine aldolase catalyzed reaction and its application to the synthesis of mycestericin d Tetrahedron Letters 1996 37:2791-2794 DOI:10.1016/0040-4039(96)00430-3
- Lin, C. C., Kimura, T., Wu, S. H., WeitzSchmidt, G., Wong, C. H. Liposome-like fucopeptides as sialyl Lewis X mimetics Bioorganic & Medicinal Chemistry Letters 1996 6:2755-2760 DOI:10.1016/s0960-894x(96)00509-4
- Murray, B. W., Takayama, S., Schultz, J., Wong, C. H. Mechanism and specificity of human α-1,3-fucosyltransferase V Biochemistry 1996 35:11183-11195 DOI:10.1021/bi961065a PMID:8780523
- Alper, P. B., Hung, S. C., Wong, C. H. Metal catalyzed diazo transfer for the synthesis of azides from amines Tetrahedron Letters 1996 37:6029-6032 DOI:10.1016/0040-4039(96)01307-x
- DeLuca, C., Lansing, M., Crescenzi, F., Martini, I., Shen, G. J., Oregan, M., Wong, C. H. Overexpression, one-step purification and characterization of udp-glucose dehydrogenase and udp-n-acetylglucosamine pyrophosphorylase Bioorganic & Medicinal Chemistry 1996 4:131-141 DOI:10.1016/0968-0896(95)00159-x PMID:8689233
- Park, W. K. C., Auer, M., Jaksche, H., Wong, C. H. Rapid combinatorial synthesis of aminoglycoside antibiotic mimetics: Use of a polyethylene glycol-linked amine and a neamine-derived aldehyde in multiple component condensation as a strategy for the discovery of new inhibitors of the hiv rna rev responsive element Journal of the American Chemical Society 1996 118:10150-10155 DOI:10.1021/ja9612817
- Hiruma, K., Kajimoto, T., WeitzSchmidt, G., Ollmann, I., Wong, C. H. Rational design and synthesis of a 1,1-linked disaccharide that is 5 times as active as sialyl lewis x in binding to e-selectin Journal of the American Chemical Society 1996 118:9265-9270 DOI:10.1021/ja9611093
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- Hung, S. C., Wong, C. H. Samarium diiodide mediated coupling of glycosyl phosphates with carbon radical or anion acceptors - synthesis of c-glycosides Angewandte Chemie-International Edition 1996 35:2671-2674 DOI:10.1002/anie.199626711
- Qiao, L., Murray, B. W., Shimazaki, M., Schultz, J., Wong, C. H. Synergistic inhibition of human alpha-1,3-fucosyltransferase v Journal of the American Chemical Society 1996 118:7653-7662 DOI:10.1021/ja960274f
- Fitz, W., Rosenthal, P. B., Wong, C. H. Synthesis and inhibitory properties of a thiomethylmercuric sialic acid with application to the x-ray structure determination of 9-o-acetylsialic acid esterase from influenza c virus Bioorganic & Medicinal Chemistry 1996 4:1349-1353 DOI:10.1016/0968-0896(96)00123-x PMID:8879557
- Qian, X. H., MorisVaras, F., Wong, C. H. Synthesis of c-2-symmetrical polyhydroxyazepanes as inhibitors of glycosidases Bioorganic & Medicinal Chemistry Letters 1996 6:1117-1122
- Wu, S. H., Shimazaki, M., Lin, C. C., Qiao, L., Moree, W. J., WeitzSchmidt, G., Wong, C. H. Synthesis of fucopeptides as sialyl lewis X mimetics Angewandte Chemie-International Edition 1996 35:88-90 DOI:10.1002/anie.199600881
- Hung, S. C., Wong, C. H. Synthesis of glycosyl chlorides with acid-labile protecting groups Tetrahedron Letters 1996 37:4903-4906 DOI:10.1016/0040-4039(96)01006-4
- Takayama, S., Shimazaki, M., Qiao, L., Wong, C. H. Synthesis of lactosamine derivatives using beta-d-galactosidase from bacillus circulans Bioorganic & Medicinal Chemistry Letters 1996 6:1123-1126 DOI:10.1016/0960-894x(96)00184-9
- Lin, C. C., Shimazaki, M., Heck, M. P., Aoki, S., Wang, R., Kimura, T., Ritzen, H., Takayama, S., Wu, S. H., WeitzSchmidt, G., Wong, C. H. Synthesis of sialyl Lewis X mimetics and related structures using the glycosyl phosphite methodology and evaluation of E-selectin inhibition Journal of the American Chemical Society 1996 118:6826-6840 DOI:10.1021/ja952265x
- Wang, R., Wong, C. H. Synthesis of sialyl Lewis X mimetics: Use of O-α-fucosyl-(1R, 2R)-2-aminocyclohexanol as core structure Tetrahedron Letters 1996 37:5427-5430 DOI:10.1016/0040-4039(96)01114-8
- Takayama, S., Livingston, P. O., Wong, C. H. Synthesis of the melanoma-associated ganglioside 9-O-acetyl GD3 through regioselective enzymatic acetylation of GD3 using subtilisin Tetrahedron Letters 1996 37:9271-9274 DOI:10.1016/s0040-4039(97)82939-5
- Cappi, M. W., Moree, W. J., Qiao, L., Marron, T. G., WeitzSchmidt, G., Wong, C. H. The synthesis of novel 6-amido-6-deoxy-l-galactose derivatives as potent sialyl lewis(x) mimetics Angewandte Chemie-International Edition 1996 35:2346-2348 DOI:10.1002/anie.199623461
- Garciajunceda, E., Shen, G. J., Sugai, T., Wong, C. H. A new strategy for the cloning, overexpression and one-step purification of 3 dhap-dependent aldolases - rhamnulose-1-phosphate aldolase, fuculose-1-phosphate aldolase and tagatose-1,6-diphosphate aldolase Bioorganic & Medicinal Chemistry 1995 3:945-953 DOI:10.1016/0968-0896(95)00077-t PMID:7582972
- Alajarin, R., Garciajunceda, E., Wong, C. H. A short enzymatic-synthesis of l-glucose from dihydroxyacetone phosphate and l-glyceraldehyde Journal of Organic Chemistry 1995 60:4294-4295 DOI:10.1021/jo00118a058
- Fitz, W., Schwark, J. R., Wong, C. H. Aldotetroses and c(3)-modified aldohexoses as substrates for n-acetylneuraminic acid aldolase - a model for the explanation of the normal and the inversed stereoselectivity Journal of Organic Chemistry 1995 60:3663-3670 DOI:10.1021/jo00117a016
- Hogg, J. H., Ollmann, I. R., Haeggstrom, J. Z., Wetterholm, A., Samuelsson, B., Wong, C. H. Amino hydroxamic acids as potent inhibitors of leukotriene A4 hydrolase Bioorganic & Medicinal Chemistry 1995 3:1405-1415 DOI:10.1016/0968-0896(95)00128-4 PMID:8564408
- Vassilev, V. P., Uchiyama, T., Kajimoto, T., Wong, C. H. An efficient chemoenzymatic synthesis of alpha-amino-beta-hydroxy-gamma-butyrolactone Tetrahedron Letters 1995 36:5063-5064 DOI:10.1016/00404-0399(50)09242-
- Sugai, T., Lin, C. H., Shen, G. J., Wong, C. H. CMP-KDO synthetase: overproduction and application to the synthesis of CMP-KDO and analogs Bioorganic & Medicinal Chemistry 1995 3:313-320 DOI:10.1016/0968-0896(95)00023-a PMID:7606392
- Garciajunceda, E., Shen, G. J., Alajarin, R., Wong, C. H. Cloning and overexpression of rhamnose isomerase and fucose isomerase Bioorganic & Medicinal Chemistry 1995 3:1349-1355 DOI:10.1016/0968-0896(95)00119-2 PMID:8564401
- Stura, E. A., Ghosh, S., Garciajunceda, E., Chen, L. R., Wong, C. H., Wilson, I. A. Crystallization and preliminary crystallographic data for class-i deoxyribose-5-phosphate aldolase from escherichia-coli - an application of reverse screening Proteins-Structure Function and Genetics 1995 22:67-72 DOI:10.1002/prot.340220110 PMID:7675789
- Uchiyama, T., Vassilev, V. P., Kajimoto, T., Wong, W. C., Huang, H. M., Lin, C. C., Wong, C. H. Design and synthesis of sialyl-Lewis X mimetics Journal of the American Chemical Society 1995 117:5395-5396 DOI:10.1021/ja00124a037
- Wong, C. H. Enzymatic and chemoenzymatic synthesis of carbohydrates Pure and Applied Chemistry 1995 67:1609-1616 DOI:10.1351/pac199567101609
- Lin, C. H., Shimazaki, M., Wong, C. H., Koketsu, M., Juneja, L. R., Kim, M. Enzymatic synthesis of a sialyl Lewis X dimer from egg yolk as an inhibitor of E-selectin Bioorganic & Medicinal Chemistry 1995 3:1625-1630 DOI:10.1016/0968-0896(95)00150-6 PMID:8770386
- Lin, C. H., Shen, G. J., Garciajunceda, E., Wong, C. H. Enzymatic-synthesis and regeneration of 3'-phosphoadenosine 5'-phosphosulfate (PAPS) for regioselective sulfation of oligosaccharides Journal of the American Chemical Society 1995 117:8031-8032 DOI:10.1021/ja00135a028
- Deluca, C., Lansing, M., Martini, I., Crescenzi, F., Shen, G. J., Oregan, M., Wong, C. H. Enzymatic-synthesis of hyaluronic-acid with regeneration of sugar nucleotides Journal of the American Chemical Society 1995 117:5869-5870 DOI:10.1021/ja00126a034
- Wong, C. H., Alajarin, R., Morisvaras, F., Blanco, O., Garciajunceda, E. Enzymatic-synthesis of l-fucose and analogs Journal of Organic Chemistry 1995 60:7360-7363 DOI:10.1021/jo00127a052
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- Vassilev, V. P., Uchiyama, T., Kajimoto, T., Wong, C. H. L-threonine aldolase in organic-synthesis - preparation of novel beta-hydroxy-alpha-amino acids Tetrahedron Letters 1995 36:4081-4084 DOI:10.1016/0040-4039(95)00720-w
- Defrees, S. A., Kosch, W., Way, W., Paulson, J. C., Sabesan, S., Halcomb, R. L., Huang, D. H., Ichikawa, Y., Wong, C. H. Ligand recognition by e-selectin - synthesis, inhibitory activity, and conformational-analysis of bivalent sialyl-lewis-x analogs Journal of the American Chemical Society 1995 117:66-79 DOI:10.1021/ja00106a008
- Wang, P. G., Fitz, W., Wong, C. H. Making complex carbohydrates via enzymatic routes ChemTech 1995 25:22-32
- Wetterholm, A., Haeggstrom, J. Z., Samuelsson, B., Yuan, W., Munoz, B., Wong, C. H. Potent and selective inhibitors of leukotriene a(4) hydrolase - effects on purified enzyme and human polymorphonuclear leukocytes Journal of Pharmacology and Experimental Therapeutics 1995 275:31-37 PMID:7562564
- Ikeda, T., Kajimoto, T., Nohara, T., Kinjo, J., Wong, C. H. Preparation of a neoglycolipid carrying the oligosaccharide component of saponin from albizzia julibrissin Tetrahedron Letters 1995 36:1509-1510 DOI:10.1016/0040-4039(95)00072-k
- Wong, C. H., Garciajunceda, E., Chen, L. R., Blanco, O., Gijsen, H. J. M., Steensma, D. H. Recombinant 2-deoxyribose-5-phosphate aldolase in organic-synthesis - use of sequential 2-substrate and 3-substrate aldol reactions Journal of the American Chemical Society 1995 117:3333-3339 DOI:10.1021/ja00117a003
- Slee, D. H., Laslo, K. L., Elder, J. H., Ollmann, I. R., Gustchina, A., Kervinen, J., Zdanov, A., Wlodawer, A., Wong, C. H. Selectivity in the inhibition of HIV and FIV protease - inhibitory and mechanistic studies of pyrrolidine-containing alpha-keto amide and hydroxyethylamine core structures Journal of the American Chemical Society 1995 117:11867-11878 DOI:10.1021/ja00153a008
- Gijsen, H. J. M., Wong, C. H. Sequential 3-substrate and 4-substrate aldol reactions catalyzed by aldolases Journal of the American Chemical Society 1995 117:7585-7591 DOI:10.1021/ja00134a001
- Gijsen, H. J. M., Wong, C. H. Sequential one-pot aldol reactions catalyzed by 2-deoxyribose-5-phosphate aldolase and fructose-1,6-diphosphate aldolase Journal of the American Chemical Society 1995 117:2947-2948 DOI:10.1021/ja00115a038
- Wong, C. H., Provencher, L., Porco, J. A., Jung, S. H., Wang, Y. F., Chen, L. R., Wang, R., Steensma, D. H. Synthesis and evaluation of homoaza sugars as glycosidase inhibitors Journal of Organic Chemistry 1995 60:1492-1501 DOI:10.1021/jo00111a007
- Hiranuma, S., Shimizu, T., Nakata, T., Kajimoto, T., Wong, C. H. Synthesis and inhibition analysis of 5-membered homoazasugars from d-arabinofuranose via an sn2 reaction of the chloromethylsulfonate Tetrahedron Letters 1995 36:8247-8250 DOI:10.1016/0040-4039(95)01769-e
- Gijsen, H. J. M., Wong, C. H. Synthesis of a cyclitol via a tandem enzymatic aldol - intramolecular horner-wadsworth-emmons reaction Tetrahedron Letters 1995 36:7057-7060 DOI:10.1016/0040-4039(95)01483-x
- Huang, H. M., Wong, C. H. Synthesis of biologically-active sialyl-lewis-x mimetics Journal of Organic Chemistry 1995 60:3100-3106 DOI:10.1021/jo00115a027
- Chou, W. C., Fotsch, C., Wong, C. H. Synthesis of nitrocyclitols based on enzymatic aldol reaction and intramolecular nitroaldol reaction Journal of Organic Chemistry 1995 60:2916-2917 DOI:10.1021/jo00114a051
- Hiranuma, S., Kajimoto, T., Wong, C. H. A facile synthesis of 1-thiopentofuranoside Tetrahedron Letters 1994 35:5257-5260 DOI:10.1016/s0040-4039(00)77078-x
- Chou, W. C., Chen, L. H., Fang, J. M., Wong, C. H. A new route to deoxythiosugars based on aldolases Journal of the American Chemical Society 1994 116:6191-6194 DOI:10.1021/ja00093a018
- Jung, S. H., Jeong, J. H., Miller, P., Wong, C. H. An efficient multigram-scale preparation of dihydroxyacetone phosphate Journal of Organic Chemistry 1994 59:7182-7184 DOI:10.1021/jo00102a060
- Henderson, I., Laslo, K., Wong, C. H. Chemoenzymatic synthesis of homoazasugars Tetrahedron Letters 1994 35:359-362 DOI:10.1016/0040-4039(94)85053-4
- Fitz, W., Wong, C. H. Combined use of subtilisin and n-acetylneuraminic acid aldolase for the synthesis of a fluorescent sialic-acid Journal of Organic Chemistry 1994 59:8279-8280 DOI:10.1021/jo00105a057
- Sears, P., Schuster, M., Wang, P., Witte, K., Wong, C. H. Engineering subtilisin for peptide coupling - studies on the effects of counterions and site-specific modifications on the stability and specificity of the enzyme Journal of the American Chemical Society 1994 116:6521-6530 DOI:10.1021/ja00094a005
- Halcomb, R. L., Fitz, W., Wong, C. H. Enzymatic-synthesis of 7-deoxy-n-acetylneuraminic acid and 7-o-methyl-n-acetylneuraminic acid Tetrahedron-Asymmetry 1994 5:2437-2442 DOI:10.1016/s0957-4166(00)80390-0
- Fang, J. M., Wong, C. H. Enzymes in organic-synthesis - alteration of reversible-reactions to irreversible-processes Synlett 1994 393-402
- Siuzdak, G., Zheng, Z. L., Rhamphal, J. Y., Ichikawa, Y., Nicolaou, K. C., Gaeta, F. C. A., Chatman, K. S., Wong, C. H. Examination of the sialyl-lewis-x calcium complex by electrospray mass-spectrometry Bioorganic & Medicinal Chemistry Letters 1994 4:2863-2866 DOI:10.1016/s0960-894x(01)80829-5
- Aoki, S., Kondo, H., Wong, C. H. Glycosyl phosphites as glycosylation reagents Neoglycoconjugates, Pt B 1994 247:193-211 PMID:7898353
- Kondo, H., Aoki, S., Ichikawa, Y., Halcomb, R. L., Ritzen, H., Wong, C. H. Glycosyl phosphites as glycosylation reagents - scope and mechanism Journal of Organic Chemistry 1994 59:864-877 DOI:10.1021/jo00083a032
- Marquardt, J. L., Brown, E. D., Lane, W. S., Haley, T. M., Ichikawa, Y., Wong, C. H., Walsh, C. T. Kinetics, stoichiometry, and identification of the reactive thiolate in the inactivation of udp-glcnac enolpyruvoyl transferase by the antibiotic fosfomycin Biochemistry 1994 33:10646-10651 DOI:10.1021/bi00201a011 PMID:8075065
- Herrmann, G. F., Wang, P., Shen, G. J., Garciajunceda, E., Khan, S. H., Matta, K. L., Wong, C. H. Large-scale production of recombinant alpha-1,2-mannosyltransferase from escherichia-coli for the study of acceptor specificity and use of the recombinant whole cells in synthesis Journal of Organic Chemistry 1994 59:6356-6362 DOI:10.1021/jo00100a043
- Herrmann, G. F., Wang, P., Shen, G. J., Wong, C. H. Recombinant whole cells as catalysts for the enzymatic-synthesis of oligosaccharides and glycopeptides Angewandte Chemie-International Edition 1994 33:1241-1242 DOI:10.1002/anie.199412411
- Ichikawa, Y., Wang, R., Wong, C. H. Regeneration of sugar nucleotide for enzymatic oligosaccharide synthesis Neoglycoconjugates, Pt B 1994 247:107-127 PMID:7898347
- Wang, Y. F., Takaoka, Y., Wong, C. H. Remarkable stereoselectivity in the inhibition of alpha-galactosidase from coffee bean by a new polyhydroxypyrrolidine inhibitor Angewandte Chemie-International Edition 1994 33:1242-1244 DOI:10.1002/anie.199412421
- Schuster, M., Wang, P., Paulson, J. C., Wong, C. H. Solid-phase chemical-enzymatic synthesis of glycopeptides and oligosaccharides Journal of the American Chemical Society 1994 116:1135-1136 DOI:10.1021/ja00082a047
- Halcomb, R. L., Huang, H. M., Wong, C. H. Solution-phase and solid-phase synthesis of inhibitors of helicobacter-pylori attachment and e-selectin-mediated leukocyte adhesion Journal of the American Chemical Society 1994 116:11315-11322 DOI:10.1021/ja00104a011
- Ichikawa, Y., Halcomb, R. L., Wong, C. H. Sticky solutions Chemistry in Britain 1994 30:117-118, 120
- Fotsch, C. H., Wong, C. H. Synthesis of a guanidino-sugar as a glycosyl cation mimic Tetrahedron Letters 1994 35:3481-3484 DOI:10.1016/s0040-4039(00)73215-1
- Henderson, I., Sharpless, K. B., Wong, C. H. Synthesis of carbohydrates via tandem use of the osmium-catalyzed asymmetric dihydroxylation and enzyme-catalyzed aldol addition-reactions Journal of the American Chemical Society 1994 116:558-561 DOI:10.1021/ja00081a016
- Yuasa, H., Kajimoto, T., Wong, C. H. Synthesis of iminothiasugar as a potential transition-state analog inhibitor of glycosyltransfer reactions Tetrahedron Letters 1994 35:8243-8246 DOI:10.1016/0040-4039(94)88293-2
- Gijsen, H. J. M., Wong, C. H. Unprecedented asymmetric aldol reactions with 3 aldehyde substrates catalyzed by 2-deoxyribose-5-phosphate aldolase Journal of the American Chemical Society 1994 116:8422-8423 DOI:10.1021/ja00097a082
- Look, G. C., Ichikawa, Y., Shen, G. J., Cheng, P. W., Wong, C. H. A combined chemical and enzymatic strategy for the construction of carbohydrate-containing antigen core units Journal of Organic Chemistry 1993 58:4326-4330 DOI:10.1021/jo00068a030
- Herrmann, G. F., Ichikawa, Y., Wandrey, C., Gaeta, F. C. A., Paulson, J. C., Wong, C. H. A new multienzyme system for a one-pot synthesis of sialyl oligosaccharides - combined use of beta-galactosidase and alpha(2,6)-sialyltransferase coupled with regeneration insitu of cmp-sialic acid Tetrahedron Letters 1993 34:3091-3094 DOI:10.1016/s0040-4039(00)93387-2
- Wang, Y. F., Dumas, D. P., Wong, C. H. Chemoenzymatic synthesis of 5-membered azasugars as inhibitors of fucosidase and fucosyl-transferase - an issue regarding the stereochemistry discrimination at transition-states Tetrahedron Letters 1993 34:403-406
- Wong, C. H. Development of enzymes for chemoenzymatic synthesis Chimia 1993 47:127-132
- Wei, Y. A., Munoz, B., Wong, C. H., Haeggstrom, J. Z., Wetterholm, A., Samuelsson, B. Development of selective tight-binding inhibitors of leukotriene-a4 hydrolase Journal of Medicinal Chemistry 1993 36:211-220 PMID:8423594
- Wong, C. H., Schuster, M., Wang, P., Sears, P. Enzymatic-synthesis of N-linked and O-linked glycopeptides Journal of the American Chemical Society 1993 115:5893-5901 DOI:10.1021/ja00067a001
- Look, G. C., Fotsch, C. H., Wong, C. H. Enzyme-catalyzed organic-synthesis - practical routes to aza sugars and their analogs for use as glycoprocessing inhibitors Accounts of Chemical Research 1993 26:182-190 DOI:10.1021/ar00028a008
- Wong, C. H., Liu, K. K. C., Kajimoto, T., Chen, L., Zhong, Z., Dumas, D. P., Liu, J. L. C., Ichikawa, Y. Enzymes for carbohydrate and peptide syntheses Indian Journal of Chemistry Section B-Organic Chemistry Including Medicinal Chemistry 1993 32:135-139
- Wang, P., Shen, G. J., Wang, Y. F., Ichikawa, Y., Wong, C. H. Enzymes in oligosaccharide synthesis - active-domain overproduction, specificity study, and synthetic use of an alpha-1,2-mannosyltransferase with regeneration of gdp-man Journal of Organic Chemistry 1993 58:3985-3990 DOI:10.1021/jo00067a035
- Siuzdak, G., Ichikawa, Y., Caulfield, T. J., Munoz, B., Wong, C. H., Nicolaou, K. C. Evidence of ca2+-dependent carbohydrate association through ion spray mass-spectrometry Journal of the American Chemical Society 1993 115:2877-2881 DOI:10.1021/ja00060a040
- Takaoka, Y., Kajimoto, T., Wong, C. H. Inhibition of n-acetylglucosaminyltransfer enzymes - chemical-enzymatic synthesis of new 5-membered acetamido azasugars Journal of Organic Chemistry 1993 58:4809-4812 DOI:10.1021/jo00070a013
- Defrees, S. A., Gaeta, F. C. A., Lin, Y. C., Ichikawa, Y., Wong, C. H. Ligand recognition by e-selectin - analysis of conformation and activity of synthetic monomeric and bivalent sialyl lewis-x analogs Journal of the American Chemical Society 1993 115:7549-7550 DOI:10.1021/ja00069a083
- Schuster, M., Munoz, B., Yuan, W., Wong, C. H. Papain-catalyzed synthesis of peptide isosteres Tetrahedron Letters 1993 34:1247-1250 DOI:10.1016/s0040-4039(00)91765-9
- Wong, C. H., Ichikawa, Y., Kajimoto, T., Liu, K. K. C., Shen, G. J., Lin, C. H., Wang, Y. F., Dumas, D. P., Lin, Y. C., Wang, R., Look, G. C. Practical synthesis of carbohydrates based on aldolases and glycosyl transferases Pure and Applied Chemistry 1993 65:803-808 DOI:10.1351/pac199365040803
- Sim, M. M., Kondo, H., Wong, C. H. Synthesis and use of glycosyl phosphites - an effective route to glycosyl phosphates, sugar nucleotides, and glycosides Journal of the American Chemical Society 1993 115:2260-2267 DOI:10.1021/ja00059a023
- Sugai, T., Shen, G. J., Ichikawa, Y., Wong, C. H. Synthesis of 3-deoxy-d-manno-2-octulosonic acid (kdo) and its analogs based on kdo aldolase-catalyzed reactions Journal of the American Chemical Society 1993 115:413-421 DOI:10.1021/ja00055a008
- Halcomb, R. L., Wong, C. H. Synthesis of oligosaccharides, glycopeptides, and glycolipids Current Opinion in Structural Biology 1993 3:694-700 DOI:10.1016/0959-440x(93)90052-m
- Wang, P., Schuster, M., Wang, Y. F., Wong, C. H. Synthesis of phospholipid inhibitor conjugates by enzymatic transphosphatidylation with phospholipase-d Journal of the American Chemical Society 1993 115:10487-10491 DOI:10.1021/ja00076a004
- Sugai, T., Ritzen, H., Wong, C. H. Towards the chemoenzymatic synthesis of lipid-a Tetrahedron-Asymmetry 1993 4:1051-1058 DOI:10.1016/s0957-4166(00)80153-6
- Wong, C. H.*, Wang, R.*, Ichikawa, Y. Regeneration of sugar nucleotide for enzymic oligosaccharide synthesis: use of Gal-1-phosphate uridyltransferase in the regeneration of UDP-galactose, UDP-2-deoxygalactose, and UDP-galactosamine Journal of Organic Chemistry 1992 57:4343-4344 DOI:10.1021/jo00042a008 (* = equal contribution)
- Look, G. C., Wong, C. H. A facile enzymatic-synthesis of gal-beta-1,3glucal - a key intermediate for the synthesis of le(a) and sialyl le(a) Tetrahedron Letters 1992 33:4253-4256 DOI:10.1016/s0040-4039(00)74231-6
- Liu, K. K. C., Wong, C. H. A new strategy for the synthesis of nucleoside analogs based on enzyme-catalyzed aldol reactions Journal of Organic Chemistry 1992 57:4789-4791 DOI:10.1021/jo00044a005
- Bradshaw, C. W., Fu, H., Shen, G. J., Wong, C. H. A pseudomonas sp alcohol-dehydrogenase with broad substrate-specificity and unusual stereospecificity for organic-synthesis Journal of Organic Chemistry 1992 57:1526-1532 DOI:10.1021/jo00031a036
- Dumas, D. P., Kajimoto, T., Liu, K. K. C., Wong, C. H., Berkowitz, D. B., Danishefsky, S. J. Azasugar and glycal inhibitors of alpha-l-fucosidase Bioorganic & Medicinal Chemistry Letters 1992 2:33-36 DOI:10.1016/s0960-894x(00)80649-6
- Kondo, H., Ichikawa, Y., Wong, C. H. Beta-sialyl phosphite and phosphoramidite - synthesis and application to the chemoenzymatic synthesis of cmp-sialic acid and sialyl oligosaccharides Journal of the American Chemical Society 1992 114:8748-8750 DOI:10.1021/ja00048a085
- Ichikawa, Y., Lin, Y. C., Dumas, D. P., Shen, G. J., Garciajunceda, E., Williams, M. A., Bayer, R., Ketcham, C., Walker, L. E., Paulson, J. C., Wong, C. H. Chemical-enzymatic synthesis and conformational-analysis of sialyl lewis-x and derivatives Journal of the American Chemical Society 1992 114:9283-9298 DOI:10.1021/ja00050a007
- Fu, H., Kondo, H., Ichikawa, Y., Look, G. C., Wong, C. H. Chloroperoxidase-catalyzed asymmetric-synthesis - enantioselective reactions of chiral hydroperoxides with sulfides and bromohydration of glycals Journal of Organic Chemistry 1992 57:7265-7270 DOI:10.1021/jo00052a048
- Lin, Y. C., Hummel, C. W., Huang, D. H., Ichikawa, Y., Nicolaou, K. C., Wong, C. H. Conformational studies of sialyl lewis-x in aqueous-solution Journal of the American Chemical Society 1992 114:5452-5454 DOI:10.1021/ja00039a082
- Chen, L. R., Dumas, D. P., Wong, C. H. Deoxyribose-5-phosphate aldolase as a catalyst in asymmetric aldol condensation Journal of the American Chemical Society 1992 114:741-748 DOI:10.1021/ja00028a050
- Wong, C. H., Liu, K. K. C., Kajimoto, T., Chen, L. R., Zhong, Z. Y., Ichikawa, Y., Shen, G. J. Developing better enzymes for organic-synthesis Annals of the New York Academy of Sciences 1992 672:343-351 DOI:10.1111/j.1749-6632.1992.tb35644.x PMID:1476380
- Ichikawa, Y., Sim, M. M., Wong, C. H. Efficient chemical synthesis of gdp-fucose Journal of Organic Chemistry 1992 57:2943-2946 DOI:10.1021/jo00036a036
- Liu, K. K. C., Wong, C. H. Enzymatic halohydration of glycals Journal of Organic Chemistry 1992 57:3748-3750 DOI:10.1021/jo00039a050
- Bradshaw, C. W., Lalonde, J. J., Wong, C. H. Enzymatic-synthesis of (r) and (s) 1-deuterohexanol Applied Biochemistry and Biotechnology 1992 33:15-24 DOI:10.1007/bf02922180 PMID:1416953
- Ichikawa, Y., Look, G. C., Wong, C. H. Enzyme-catalyzed oligosaccharide synthesis Analytical Biochemistry 1992 202:215-238 DOI:10.1016/0003-2697(92)90099-s PMID:1519746
- Wong, C. H., Liu, K. K. C., Kajimoto, T., Chen, L. H., Zhong, Z. Y., Dumas, D. P., Liu, J. L. C., Ichikawa, Y. Enzymes for carbohydrate and peptide syntheses Pure and Applied Chemistry 1992 64:1197-1202 DOI:10.1351/pac199264081197
- Bradshaw, C. W., Hummel, W., Wong, C. H. Lactobacillus-kefir alcohol-dehydrogenase - a useful catalyst for synthesis Journal of Organic Chemistry 1992 57:1532-1536 DOI:10.1021/jo00031a037
- Yuan, W., Wong, C. H., Haeggstrom, J. Z., Wetterholm, A., Samuelsson, B. Novel tight-binding inhibitors of leukotriene-a(4) hydrolase Journal of the American Chemical Society 1992 114:6552-6553 DOI:10.1021/ja00042a041
- Liu, J. L. C., Shen, G. J., Ichikawa, Y., Rutan, J. F., Zapata, G., Vann, W. F., Wong, C. H. Overproduction of cmp-sialic acid synthetase for organic-synthesis Journal of the American Chemical Society 1992 114:3901-3910 DOI:10.1021/ja00036a044
- Danishefsky, S. J., Gervay, J., Peterson, J. M., McDonald, F. E., Koseki, K., Oriyama, T., Griffith, D. A., Wong, C. H., Dumas, D. P. Remarkable regioselectivity in the chemical glycosylation of glycal acceptors - a concise solution to the synthesis of sialyl-lewis-x glycal Journal of the American Chemical Society 1992 114:8329-8331 DOI:10.1021/ja00047a077
- Fernholz, E., Schloeder, D., Liu, K. K. C., Bradshaw, C. W., Huang, H. M., Janda, K., Lerner, R. A., Wong, C. H. Specificity of antibody-catalyzed transesterifications using enol esters - a comparison with lipase reactions Journal of Organic Chemistry 1992 57:4756-4761 DOI:10.1021/jo00043a042
- Wong, C. H., Dumas, D. P., Ichikawa, Y., Koseki, K., Danishefsky, S. J., Weston, B. W., Lowe, J. B. Specificity, inhibition, and synthetic utility of a recombinant human alpha-1,3-fucosyl-transferase Journal of the American Chemical Society 1992 114:7321-7322 DOI:10.1021/ja00044a068
- Ichikawa, Y., Look, G. C., Wong, C. H., Kajimoto, T. Synthesis of oligosaccharides using glycosyltransferases Journal of Synthetic Organic Chemistry Japan 1992 50:441-450
- Lin, C. H., Sugai, T., Halcomb, R. L., Ichikawa, Y., Wong, C. H. Unusual stereoselectivity in sialic-acid aldolase-catalyzed aldol condensations - synthesis of both enantiomers of high-carbon monosaccharides Journal of the American Chemical Society 1992 114:10138-10145 DOI:10.1021/ja00052a008
- Gautheronlenarvor, C., Ichikawa, Y., Wong, C. H. A complete change of stereoselectivity in sialic-acid aldolase reactions - a novel synthetic route to the kdo type of 9-carbon-l sugars Journal of the American Chemical Society 1991 113:7816-7818 DOI:10.1021/ja00020a084
- Ichikawa, Y., Liu, J. L. C., Shen, G. J., Wong, C. H. A highly efficient multienzyme system for the one-step synthesis of a sialyl trisaccharide - insitu generation of sialic-acid and n-acetyllactosamine coupled with regeneration of udp-glucose, udp-galactose, and cmp-sialic acid Journal of the American Chemical Society 1991 113:6300-6302 DOI:10.1021/ja00016a073
- Bradshaw, C. W., Shen, G. J., Wong, C. H. A new alcohol-dehydrogenase with unique stereospecificity from pseudomonas sp Bioorganic Chemistry 1991 19:398-417 DOI:10.1016/0045-2068(91)90022-h
- Zhong, Z., Bibbs, J. A., Yuan, W., Wong, C. H. Active-site-directed modification of subtilisin Journal of the American Chemical Society 1991 113:2259-2263 DOI:10.1021/ja00006a052
- Wong, C. H. Aldolases in synthesis of fluorosugars ACS Symposium Series 1991 456:156-162 DOI:10.1021/bk-1991-0456.ch010
- Pederson, R. L., Esker, J., Wong, C. H. An improved synthesis of dihydroxyacetone phosphate Tetrahedron 1991 47:2643-2648 DOI:10.1016/s0040-4020(01)81796-8
- Fu, H., Shen, G. J., Wong, C. H. Asymmetric epoxidation of allyl alcohol derivatives by omega-hydroxylase from Pseudomonas oleovorans Recueil des Travaux Chimiques des Pays-Bas 1991 110:167-170 DOI:10.1002/recl.19911100506
- Zhong, Z. Y., Wong, C. H. Development of new enzymatic catalysts for peptide-synthesis in aqueous and organic-solvents Biomedica Biochimica Acta 1991 50:S9-S14 PMID:1820067
- Zhong, Z. Y., Liu, J. L. C., Dinterman, L. M., Finkelman, M. A. J., Mueller, W. T., Rollence, M. L., Whitlow, M., Wong, C. H. Engineering subtilisin for reaction in dimethylformamide Journal of the American Chemical Society 1991 113:683-684 DOI:10.1021/ja00002a051
- Wong, C. H., Shen, G. J., Pederson, R. L., Wang, Y. F., Hennen, W. J. Enzymatic catalysis in organic-synthesis Methods in Enzymology 1991 202:591-620 DOI:10.1016/0076-6879(91)02028-8 PMID:1784190
- Dumas, D. P., Ichikawa, Y., Wong, C. H., Lowe, J. B., Nair, R. P. Enzymatic-synthesis of sialyl lex and derivatives based on a recombinant fucosyl-transferase Bioorganic & Medicinal Chemistry Letters 1991 1:425-428 DOI:10.1016/s0960-894x(00)80270-x
- Drueckhammer, D. G., Hennen, W. J., Pederson, R. L., Barbas, C. F., Gautheron, C. M., Krach, T., Wong, C. H. Enzyme catalysis in synthetic carbohydrate-chemistry Synthesis-Stuttgart 1991 499-525
- Kajimoto, T., Liu, K. K. C., Pederson, R. L., Zhong, Z. Y., Ichikawa, Y., Porco, J. A., Wong, C. H. Enzyme-catalyzed aldol condensation for asymmetric-synthesis of azasugars - synthesis, evaluation, and modeling of glycosidase inhibitors Journal of the American Chemical Society 1991 113:6187-6196 DOI:10.1021/ja00016a039
- Bradshaw, C. W., Wong, C. H., Hummel, W., Kula, M. R. Enzyme-catalyzed asymmetric-synthesis of (s)-2-amino-4-phenylbutanoic acid and (r)-2-hydroxy-4-phenylbutanoic acid Bioorganic Chemistry 1991 19:29-39 DOI:10.1016/0045-2068(91)90041-m
- Ichikawa, Y., Shen, G. J., Wong, C. H. Enzyme-catalyzed synthesis of sialyl oligosaccharide with insitu regeneration of cmp-sialic acid Journal of the American Chemical Society 1991 113:4698-4700 DOI:10.1021/ja00012a058
- Liu, K. K. C., Pederson, R. L., Wong, C. H. Fructose 1,6-diphosphate aldolase-catalyzed stereoselective c-c bond formation Journal of the Chemical Society-Perkin Transactions 1 1991 2669-2673 DOI:10.1039/p19910002669
- Gautheronlenarvor, C., Wong, C. H. Glycosyltransferase-catalyzed stereoselective glycosidation of monosaccharide-based glycosidase inhibitors - a new approach to the synthesis of sequence-specific glycosidase inhibitors Journal of the Chemical Society-Chemical Communications 1991 1130-1131 DOI:10.1039/c39910001130
- Wong, C. H. Microbial aldolases in carbohydrate synthesis ACS Symposium Series 1991 466:23-37 DOI:10.1021/bk-1991-0466.ch002
- Wong, C. H., Wang, K. T. New developments in enzymatic peptide-synthesis Experientia 1991 47:1123-1129 DOI:10.1007/bf01918376 PMID:1765124
- Barbas, C. F., Wong, C. H. Overexpression and substrate-specificity studies of phosphodeoxyribomutase and thymidine phosphorylase Bioorganic Chemistry 1991 19:261-269 DOI:10.1016/0045-2068(91)90051-p
- Kajimoto, T., Chen, L. R., Liu, K. K. C., Wong, C. H. Palladium-mediated stereocontrolled reductive amination of azido sugars prepared from enzymatic aldol condensation - a general-approach to the synthesis of deoxy aza sugars Journal of the American Chemical Society 1991 113:6678-6680 DOI:10.1021/ja00017a052
- Wong, C. H., Ichikawa, Y., Krach, T., Gautheronlenarvor, C., Dumas, D. P., Look, G. C. Probing the acceptor specificity of beta-1,4-galactosyltransferase for the development of enzymatic-synthesis of novel oligosaccharides Journal of the American Chemical Society 1991 113:8137-8145 DOI:10.1021/ja00021a045
- Yuan, W., Zhong, Z., Wong, C. H. Probing the inhibition of leukotriene-a4 hydrolase based on its aminopeptidase activity Bioorganic & Medicinal Chemistry Letters 1991 1:551-556 DOI:10.1016/s0960-894x(01)80464-9
- Fu, H., Newcomb, M., Wong, C. H. Pseudomonas-oleovorans monooxygenase catalyzed asymmetric epoxidation of allyl alcohol derivatives and hydroxylation of a hypersensitive radical probe with the radical ring-opening rate exceeding the oxygen rebound rate Journal of the American Chemical Society 1991 113:5878-5880 DOI:10.1021/ja00015a061
- Nicolaou, K. C., Hummel, C. W., Bockovich, N. J., Wong, C. H. Stereocontrolled synthesis of sialyl lex, the oligosaccharide binding ligand to elam-1 (sialyl = n-acetylneuramin) Journal of the Chemical Society-Chemical Communications 1991 870-872 DOI:10.1039/c39910000870
- Wong, C. H., Krach, T., Gautheronlenarvor, C., Ichikawa, Y., Look, G. C., Gaeta, F., Thompson, D., Nicolaou, K. C. Synthesis of novel disaccharides based on glycosyltransferases - beta-1,4galactosyltransferase Tetrahedron Letters 1991 32:4867-4870 DOI:10.1016/s0040-4039(00)93482-8
- Liu, K. K. C., Kajimoto, T., Chen, L. R., Zhong, Z. Y., Ichikawa, Y., Wong, C. H. Use of dihydroxyacetone phosphate dependent aldolases in the synthesis of deoxyazasugars Journal of Organic Chemistry 1991 56:6280-6289 DOI:10.1021/jo00022a013
- Shen, G. J., Wang, Y. F., Bradshaw, C., Wong, C. H. A new nad-dependent alcohol-dehydrogenase with opposite facial selectivity useful for asymmetric reduction and cofactor regeneration Journal of the Chemical Society-Chemical Communications 1990 677-679 DOI:10.1039/c39900000677
- Barbas, C. F., Wang, Y. F., Wong, C. H. Deoxyribose-5-phosphate aldolase as a synthetic catalyst Journal of the American Chemical Society 1990 112:2013-2014 DOI:10.1021/ja00161a064
- West, J. B., Hennen, W. J., Lalonde, J. L., Bibbs, J. A., Zhong, Z. Y., Meyer, E. F., Wong, C. H. Enzymes as synthetic catalysts - mechanistic and active-site considerations of natural and modified chymotrypsin Journal of the American Chemical Society 1990 112:5313-5320 DOI:10.1021/ja00169a043
- Wong, C. H., Chen, S. T., Hennen, W. J., Bibbs, J. A., Wang, Y. F., Liu, J. L. C., Pantoliano, M. W., Whitlow, M., Bryan, P. N. Enzymes in organic synthesis: use of subtilisin and a highly stable mutant derived from multiple site-specific mutations Journal of the American Chemical Society 1990 112:945-953 DOI:10.1021/ja00159a006
- Pederson, R. L., Liu, K. K. C., Rutan, J. F., Chen, L., Wong, C. H. Enzymes in organic-synthesis - synthesis of highly enantiomerically pure 1,2-epoxy aldehydes, epoxy alcohols, thiirane, aziridine, and glyceraldehyde-3-phosphate Journal of Organic Chemistry 1990 55:4897-4901 DOI:10.1021/jo00303a026
- Babiak, K. A., Ng, J. S., Dygos, J. H., Weyker, C. L., Wang, Y. F., Wong, C. H. Lipase-catalyzed irreversible transesterification using enol esters - resolution of prostaglandin synthons 4-hydroxy-2-alkyl-2-cyclopentenones and inversion of the 4s enantiomer to the 4r enantiomer Journal of Organic Chemistry 1990 55:3377-3381 DOI:10.1021/jo00297a073
- Hsu, S. H., Wu, S. S., Wang, Y. F., Wong, C. H. Lipase-catalyzed irreversible transesterification using enol esters - xad-8 immobilized lipoprotein lipase-catalyzed resolution of secondary alcohols Tetrahedron Letters 1990 31:6403-6406 DOI:10.1016/s0040-4039(00)97076-x
- Vonderosten, C. H., Gioannetti, C., Barbas, C., Pederson, R. L., Wang, Y. F., Wong, C. H., Ozaki, A., Toone, E., Whitesides, G. M., Sinskey, A. J. Molecular-cloning of aldolases for synthetic applications Annals of the New York Academy of Sciences 1990 613:771-775 PMID:2076016
- Hennen, W. J., Wong, C. H. A new method for the enzymatic-synthesis of nucleosides using purine nucleoside phosphorylase Journal of Organic Chemistry 1989 54:4692-4695 DOI:10.1021/jo00280a046
- Wang, Y. F., Wong, C. H. Enantioselective syntheses of platelet-activating factor and a phospholipase-a2 inhibitor from chiral synthons prepared enzymatically Journal of the Chinese Chemical Society 1989 36:463-468
- Pederson, R. L., Wong, C. H. Enzymatic aldol condensation as a route to heterocycles: synthesis of 1,4-dideoxy-1,4-imino-D-arabinitol, fagomine, 1-deoxynojirimycin and 1-deoxymannojirimycin Heterocycles 1989 28:477-480 DOI:10.3987/COM-88-S99
- Wong, C. H. Enzymatic catalysts in organic-synthesis Science 1989 244:1145-1152 DOI:10.1126/science.2658059 PMID:2658059
- Wong, C. H., Drueckhammer, D. G., Durrwachter, J. R., Lacher, B., Chauvet, C. J., Wang, Y. F., Sweers, H. M., Smith, G. L., Yang, L. J. S., Hennen, W. J. Enzyme-catalyzed synthesis of carbohydrates ACS Symposium Series 1989 386:317-335 DOI:10.1021/bk-1989-0386.ch018
- Wang, Y. F., Chen, S. T., Liu, K. K. C., Wong, C. H. Lipase-catalyzed irreversible trans-esterification using enol esters - resolution of cyanohydrins and syntheses of ethyl (r)-2-hydroxy-4-phenylbutyrate and (s)-propranolol Tetrahedron Letters 1989 30:1917-1920 DOI:10.1016/s0040-4039(00)99613-8
- Vonderosten, C. H., Barbas, C. F., Wong, C. H., Sinskey, A. J. Molecular-cloning, nucleotide-sequence and fine-structural analysis of the corynebacterium-glutamicum fda gene - structural comparison of corynebacterium-glutamicum fructose-1,6-biphosphate aldolase to class-i and class-ii aldolases Molecular Microbiology 1989 3:1625-1637 PMID:2615658
- Drueckhammer, D. G., Durrwachter, J. R., Pederson, R. L., Crans, D. C., Daniels, L., Wong, C. H. Reversible and insitu formation of organic arsenates and vanadates as organic phosphate mimics in enzymatic-reactions - mechanistic investigation of aldol reactions and synthetic applications Journal of Organic Chemistry 1989 54:70-77 DOI:10.1021/jo00262a021
- Chen, S. T., Wong, C. H. Studies on angiotensin-converting enzyme-inhibitors - protease catalyzed resolution of aryl 3-mercapto-2-methylpropionic ester Journal of the Chinese Chemical Society 1989 36:451-458
- Vonderosten, C. H., Sinskey, A. J., Barbas, C. F., Pederson, R. L., Wang, Y. F., Wong, C. H. Use of a recombinant bacterial fructose-1,6-diphosphate aldolase in aldol reactions - preparative syntheses of 1-deoxynojirimycin, 1-deoxymannojirimycin, 1,4-dideoxy-1,4-imino-d-arabinitol, and fagomine Journal of the American Chemical Society 1989 111:3924-3927 DOI:10.1021/ja00193a025
- Pederson, R. L., Kim, M. J., Wong, C. H. A combined chemical and enzymatic procedure for the synthesis of 1-deoxynojirimycin and 1-deoxymannojirimycin Tetrahedron Letters 1988 29:4645-4648 DOI:10.1016/s0040-4039(00)80570-5
- Barbas, C. F., Matos, J. R., West, J. B., Wong, C. H. A search for peptide ligase: cosolvent-mediated conversion of proteases to esterases for irreversible synthesis of peptides Journal of the American Chemical Society 1988 110:5162-5166 DOI:10.1021/ja00223a042
- Wong, C. H., Dreckhammer, D. G., Sweers, H. M. Chemoenzymatic synthesis of fluorosugars ACS Symposium Series 1988 374:29-42 DOI:10.1021/bk-1988-0374.ch003
- Drueckhammer, D. G., Barbas, C. F., Nozaki, K., Wong, C. H., Wood, C. Y., Ciufolini, M. A. Chemoenzymic synthesis of chiral furan-derivatives - useful building-blocks for optically-active structures Journal of Organic Chemistry 1988 53:1607-1611 DOI:10.1021/jo00243a003
- Lalonde, J. J., Bergbreiter, D. E., Wong, C. H. Enzymatic kinetic resolution of alpha-nitro alpha-methyl carboxylic-acids Journal of Organic Chemistry 1988 53:2323-2327 DOI:10.1021/jo00245a036
- Hennen, W. J., Sweers, H. M., Wang, Y. F., Wong, C. H. Enzymes in carbohydrate synthesis - lipase-catalyzed selective acylation and deacylation of furanose and pyranose derivatives Journal of Organic Chemistry 1988 53:4939-4945 DOI:10.1021/jo00256a008
- Kim, M. J., Hennen, W. J., Sweers, H. M., Wong, C. H. Enzymes in carbohydrate synthesis - n-acetylneuraminic acid aldolase catalyzed-reactions and preparation of n-acetyl-2-deoxy-d-neuraminic acid-derivatives Journal of the American Chemical Society 1988 110:6481-6486 DOI:10.1021/ja00227a031
- Durrwachter, J. R., Wong, C. H. Fructose 1,6-diphosphate aldolase catalyzed stereoselective synthesis of c-alkyl and n-containing sugars - thermodynamically controlled c-c bond formations Journal of Organic Chemistry 1988 53:4175-4181 DOI:10.1021/jo00253a004
- Wang, Y. F., Lalonde, J. J., Momongan, M., Bergbreiter, D. E., Wong, C. H. Lipase-catalyzed irreversible transesterifications using enol esters as acylating reagents - preparative enantioselective and regioselective syntheses of alcohols, glycerol derivatives, sugars, and organometallics Journal of the American Chemical Society 1988 110:7200-7205 DOI:10.1021/ja00229a041
- West, J. B., Scholten, J., Stolowich, N. J., Hogg, J. L., Scott, A. I., Wong, C. H. Modification of proteases to esterases for peptide-synthesis - methylchymotrypsin Journal of the American Chemical Society 1988 110:3709-3710 DOI:10.1021/ja00219a083
- Barbas, C. F., Wong, C. H. One-pot tripeptide syntheses from 3 single amino-acid derivatives catalyzed by papain Tetrahedron Letters 1988 29:2907-2910 DOI:10.1016/0040-4039(88)85044-5
- Drueckhammer, D. G., Sadozai, S. K., Wong, C. H., Roberts, S. M. Biphasic one-pot synthesis of two useful and separable compounds using nicotinamide cofactor-requiring enzymes: syntheses of (S)-4-hydroxyhexanoate and its lactone Enzyme and Microbial Technology 1987 9:564-570 DOI:10.1016/0141-0229(87)90089-5
- Crans, D. C., Kazlauskas, R. J., Hirschbein, B. L., Wong, C. H., Abril, O., Whitesides, G. M. Enzymatic regeneration of adenosine 5'-triphosphate: acetyl phosphate, phosphoenolpyruvate, methoxycarbonyl phosphate, dihydroxyacetone phosphate, 5-phospho-alpha-D-ribosyl pyrophosphate, uridine-5'-diphosphoglucose Methods in Enzymology 1987 136:263-280 DOI:10.1016/S0076-6879(87)36027-6 PMID:2446104
- Matos, J. R., West, J. B., Wong, C. H. Lipase catalyzed synthesis of peptides - preparation of a penicillin-g precursor and other peptides Biotechnology Letters 1987 9:233-236 DOI:10.1007/bf01027155
- Barbas, C. F., Wong, C. H. Papain catalyzed peptide-synthesis - control of amidase activity and the introduction of unusual amino-acids Journal of the Chemical Society-Chemical Communications 1987 533-534 DOI:10.1039/c39870000533
- Matos, J. R., Wong, C. H. S-adenosylmethionine - stability and stabilization Bioorganic Chemistry 1987 15:71-80 DOI:10.1016/0045-2068(87)90008-3
- Matos, J. R., Raushel, F. M., Wong, C. H. S-adenosylmethionine - studies on chemical and enzymatic-synthesis Biotechnology and Applied Biochemistry 1987 9:39-52 PMID:3566918
- West, J. B., Wong, C. H. Use of nonproteases in peptide-synthesis Tetrahedron Letters 1987 28:1629-1632 DOI:10.1016/s0040-4039(00)95377-2
- Matos, J. R., Wong, C. H. Biphasic one-pot synthesis of 2 useful and separable compounds using cofactor-requiring enzymatic-reactions - glutamate-dehydrogenase catalyzed synthesis of l-alpha-aminoadipate coupled with alcohol-dehydrogenase catalyzed synthesis of a chiral lactone Journal of Organic Chemistry 1986 51:2388-2389 DOI:10.1021/jo00362a045
- Chen, S. T., Wang, K. T., Wong, C. H. Chirally selective hydrolysis of d,l-amino acid-esters by alkaline protease Journal of the Chemical Society-Chemical Communications 1986 1514-1516 DOI:10.1039/c39860001514
- Durrwachter, J. R., Drueckhammer, D. G., Nozaki, K., Sweers, H. M., Wong, C. H. Enzymatic aldol condensation isomerization as a route to unusual sugar-derivatives Journal of the American Chemical Society 1986 108:7812-7818 DOI:10.1021/ja00284a053 PMID:22283291
- Durrwachter, J. R., Sweers, H. M., Nozaki, K., Wong, C. H. Enzymatic aldol reaction isomerization as a route to unusual sugars Tetrahedron Letters 1986 27:1261-1264 DOI:10.1016/s0040-4039(00)84233-1
- West, J. B., Wong, C. H. Enzyme-catalyzed irreversible formation of peptides containing d-amino acids Journal of Organic Chemistry 1986 51:2728-2735 DOI:10.1021/jo00364a021
- Sweers, H. M., Wong, C. H. Enzyme-catalyzed regioselective deacylation of protected sugars in carbohydrate synthesis Journal of the American Chemical Society 1986 108:6421-6422 DOI:10.1021/ja00280a068
- West, J. B., Wong, C. H. Enzyme-catalyzed synthesis of peptides containing d-amino acids Journal of the Chemical Society-Chemical Communications 1986 417-418 DOI:10.1039/c39860000417
- Wong, C. H., Matos, J. R. Enantioselective oxidation of 1,2-diols to l-alpha-hydroxy acids using coimmobilized alcohol and aldehyde dehydrogenases as catalysts Journal of Organic Chemistry 1985 50:1992-1994 DOI:10.1021/jo00211a046
- Matos, J. R., Smith, M. B., Wong, C. H. Enantioselectivity of alcohol dehydrogenase-catalyzed oxidation of 1,2-diols and aminoalcohols Bioorganic Chemistry 1985 13:121-130 DOI:10.1016/0045-2068(85)90014-8
- Wong, C. H., Drueckhammer, D. G. Enzymatic synthesis of chiral hydroxy compounds using immobilized glucose dehydrogenase from Bacillus cereus for NAD(P)H regeneration Bio-Technology 1985 3:649-651 DOI:10.1038/nbt0785-649
- Wong, C. H., Drueckhammer, D. G., Sweers, H. M. Enzymatic vs fermentative synthesis - thermostable glucose-dehydrogenase catalyzed regeneration of nad(p)h for use in enzymatic-synthesis Journal of the American Chemical Society 1985 107:4028-4031 DOI:10.1021/ja00299a044
- Root, R. L., Durrwachter, J. R., Wong, C. H. Enzymatic-synthesis of unusual sugars - galactose-oxidase catalyzed stereospecific oxidation of polyols Journal of the American Chemical Society 1985 107:2997-2999 DOI:10.1021/ja00296a041
- Whitesides, G. M., Wong, C. H. Enzymes as catalysts in synthetic organic-chemistry Angewandte Chemie-International Edition 1985 24:617-638 DOI:10.1002/anie.198506173
- Drueckhammer, D. G., Riddle, V. W., Wong, C. H. Fmn reductase catalyzed regeneration of nad(p) for use in enzymatic-synthesis Journal of Organic Chemistry 1985 50:5387-5389 DOI:10.1021/jo00225a080
- Wong, C. H., Mazenod, F. P., Whitesides, G. M. Chemical and enzymatic syntheses of 6-deoxyhexoses - conversion to 2,5-dimethyl-4-hydroxy-2,3-dihydrofuran-3-one (furaneol) and analogs Journal of Organic Chemistry 1983 48:3493-3497 DOI:10.1021/jo00168a023
- Wong, C. H., Whitesides, G. M. Enzyme-catalyzed organic-synthesis - regeneration of deuterated nicotinamide cofactors for use in large-scale enzymatic-synthesis of deuterated substances Journal of the American Chemical Society 1983 105:5012-5014 DOI:10.1021/ja00353a026
- Wong, C. H., Haynie, S. L., Whitesides, G. M. Preparation of a mixture of nucleoside triphosphates from yeast rna - use in enzymatic-synthesis requiring nucleoside triphosphate regeneration and conversion to nucleoside diphosphate sugars Journal of the American Chemical Society 1983 105:115-117 DOI:10.1021/ja00339a021
- Wong, C. H., Whitesides, G. M. Synthesis of sugars by aldolase-catalyzed condensation-reactions Journal of Organic Chemistry 1983 48:3199-3205 DOI:10.1021/jo00167a012
- Whitesides, G. M., Wong, C. H., Pollak, A. Asymmetric synthesis using cofactor-requiring enzymes ACS Symposium Series 1982 185:205-218 DOI:10.1021/bk-1982-0185.ch015
- Wong, C. H., Haynie, S. L., Whitesides, G. M. Enzyme-catalyzed synthesis of n-acetyllactosamine with insitu regeneration of uridine 5'-diphosphate glucose and uridine 5'-diphosphate galactose Journal of Organic Chemistry 1982 47:5416-5418 DOI:10.1021/jo00148a045
- Wong, C. H., Whitesides, G. M. Enzyme-catalyzed transhydrogenation between nicotinamide cofactors and its application in organic-synthesis Journal of the American Chemical Society 1982 104:3542-3544 DOI:10.1021/ja00376a067
- Wong, C. H., Pollak, A., McCurry, S. D., Sue, J. M., Knowles, J. R., Whitesides, G. M. Synthesis of ribulose 1,5-bisphosphate - routes from glucose-6-phosphate (via 6-phosphogluconate) and from adenosine-monophosphate (via ribose 5-phosphate) Methods in Enzymology 1982 89:108-121 PMID:7144568
- Dicosimo, R., Wong, C. H., Daniels, L., Whitesides, G. M. Enzyme-catalyzed organic synthesis: electrochemical regeneration of NAD(P)H from NAD(P) using methyl viologen and flavoenzymes Journal of Organic Chemistry 1981 46:4622-4623 DOI:10.1021/jo00335a078
- Wong, C. H., Whitesides, G. M. Enzyme-catalyzed organic-synthesis - nad(p)h cofactor regeneration by using glucose-6-phosphate and the glucose-6-phosphate-dehydrogenase from leuconostoc-mesenteroides Journal of the American Chemical Society 1981 103:4890-4899 DOI:10.1021/ja00406a037
- Wong, C. H., Daniels, L., Ormejohnson, W. H., Whitesides, G. M. Enzyme-catalyzed organic-synthesis - nad(p)h regeneration using dihydrogen and the hydrogenase from methanobacterium-thermoautotrophicum Journal of the American Chemical Society 1981 103:6227-6228 DOI:10.1021/ja00410a049
- Wong, C. H., Gordon, J., Cooney, C. L., Whitesides, G. M. Regeneration of nad(p)h using glucose 6-sulfate and glucose-6-phosphate-dehydrogenase Journal of Organic Chemistry 1981 46:4676-4679 DOI:10.1021/jo00336a009
- Wong, C. H., McCurry, S. D., Whitesides, G. M. Practical enzymatic syntheses of ribulose 1,5-bisphosphate and ribose 5-phosphate Journal of the American Chemical Society 1980 102:7938-7939 DOI:10.1021/ja00547a023
- Chou, S. H., Wong, C. H., Chen, S. T., Wang, K. T. Enzymatic-synthesis of oligopeptide .2. Synthesis of bis-(n-protected amino-acid) hydrazides by papain Journal of the Chinese Chemical Society 1979 26:11-15
- Wong, C. H., Chen, S. T., Wang, K. T. Enzymic-synthesis of opioid peptides Biochimica et Biophysica Acta 1979 576:247-249 DOI:10.1016/0005-2795(79)90500-2 PMID:760808
- Wong, C. H. Resolution of rs-mandelic acid Journal of the Chinese Chemical Society 1979 26:75-78
- Wong, C. H., Wang, K. T. Electrochemistry in organic-synthesis .1. Large-scale preparation of cysteine from cystine Journal of the Chinese Chemical Society 1978 25:149-151
- Chou, S. H., Chen, S. T., Wong, C. H., Wang, K. T. Enzymatic-synthesis of oligopeptide .1. Papain-catalyzed synthesis of dipeptide, tripeptide and tetrapeptide Journal of the Chinese Chemical Society 1978 25:215-218
- Wong, C. H., Wang, K. T. Mutual resolution of (+)-ephedrine and z-dl-amino acid-induced by seeding chiral salt Tetrahedron Letters 1978 3813-3816
- Wong, C. H., Wang, K. T. Mutual resolution of dl-ephedrine and n-benzyloxycarbonyl-dl-amino acids Journal of the Chinese Chemical Society 1978 25:209-214
- Wong, C. H., Ho, M. F., Wang, K. T. Preparation of optically pure n-tert-butyloxycarbonyl-o-benzyl-l-serine and its antipode Journal of Organic Chemistry 1978 43:3604-3604 DOI:10.1021/jo00412a042
- Wong, C. H., Ho, C. L., Wang, K. T. Purification of synthetic cardiotoxin by affinity chromatography Journal of Chromatography 1978 154:25-32 PMID:670366
- Wong, C. H., Chen, Y. H., Hung, M. C., Wang, K. T., Ho, C. L., Lo, T. B. Renaturation of a reduced taiwan cobra cardiotoxin Biochimica et Biophysica Acta 1978 533:105-111 DOI:10.1016/0005-2795(78)90553-6 PMID:76481
- Wong, C. H., Chen, S. T., Ho, C. L., Wang, K. T. Synthesis of a fully active snake-venom cardiotoxin by fragment condensation on solid polymer Biochimica et Biophysica Acta 1978 536:376-389 DOI:10.1016/0005-2795(78)90496-8 PMID:81691
- Wong, C. H., Chen, S. T., Wang, K. T. Resolution of amino-acids by enzymes .1. Proteolytic-enzyme bromelain for hydrolysis of l-amino-acid methyl-esters Journal of the Chinese Chemical Society 1977 24:129-133
- Kong, F. T., Lin, T. C., Wong, C. H., Wang, K. T. Synthesis of taiwan cobra venom cardiotoxin .2. Synthesis of protected hexapeptide, sequence 44-49 and protected tripeptide, sequence 50-52 Journal of the Chinese Chemical Society 1976 23:155-164
chapter
- Calarese, D., Scanlan, C., Lee, H. K., Rudd, P., Dwek, R. Toward a carbohydrate-based HIV-1 vaccine ACS Symposium Series. 161-185. 2006 DOI:10.1021/bk-2006-0932.ch007

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Wong, Chi-Huey

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education and training

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