recent publications
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academic article
- Bodrug, T., Wilson-Kubalek, E. M., Nithianantham, S., Thompson, A. F., Alfieri, A., Gaska, I., Major, J., Debs, G., Inagaki, S., Gutierrez, P., Gheber, L., McKenney, R. J., et al. The kinesin-5 tail domain directly modulates the mechanochemical cycle of the motor domain for anti-parallel microtubule sliding Elife 2020 9 DOI:10.7554/eLife.51131 PMID:31958056 PMCID:PMC7015671
- Jiang, S., Mani, N., Wilson-Kubalek, E. M., Ku, P. I., Milligan, R. A., Subramanian, R. Interplay between the kinesin and tubulin mechanochemical cycles underlies microtubule tip tracking by the non-motile ciliary kinesin Kif7 Developmental Cell 2019 49:711-730 DOI:10.1016/j.devcel.2019.04.001 PMID:31031197 PMCID:PMC6550315
- Kern, D. M., Monda, J. K., Su, K. C., Wilson-Kubalek, E. M., Cheeseman, I. M. Astrin-SKAP complex reconstitution reveals its kinetochore interaction with microtubule-bound Ndc80 Elife 2017 6 DOI:10.7554/eLife.26866
- Monda, J. K., Whitney, I. P., Tarasovetc, E. V., Wilson-Kubalek, E., Milligan, R. A., Grishchuk, E. L., Cheeseman, I. M. Microtubule tip tracking by the spindle and kinetochore protein Ska1 requires diverse tubulin-interacting surfaces Current Biology 2017 27:3666-3675 DOI:10.1016/j.cub.2017.10.018 PMID:29153323 PMCID:PMC5726585
- Wilson-Kubalek, E. M., Cheeseman, I. M., Milligan, R. A. Structural comparison of the Caenorhabditis elegans and human Ndc80 complexes bound to microtubules reveals distinct binding behavior Molecular Biology of the Cell 2016 27:1197-1203 DOI:10.1091/mbc.E15-12-0858 PMID:26941333 PMCID:PMC4831874
- Garnham, C. P., Vemu, A., Wilson-Kubalek, E. M., Yu, I., Szyk, A., Lander, G. C., Milligan, R. A., Roll-Mecak, A. Multivalent microtubule recognition by tubulin tyrosine ligase-like family glutamylases Cell 2015 161:1112-1123 DOI:10.1016/j.cell.2015.04.003 PMID:25959773 PMCID:PMC4465277
- Hsia, K. C., Wilson-Kubalek, E. M., Dottore, A., Hao, Q., Tsai, K. L., Forth, S., Shimamoto, Y., Milligan, R. A., Kapoor, T. M. Reconstitution of the augmin complex provides insights into its architecture and function Nature Cell Biology 2014 16:852-863 DOI:10.1038/ncb3030 PMID:25173975 PMCID:PMC4244909
- Hotze, E. M., Wilson-Kubalek, E., Farrand, A. J., Bentsen, L., Parker, M. W., Johnson, A. E., Tweten, R. K. Monomer-monomer interactions propagate structural transitions necessary for pore formation by the cholesterol-dependent cytolysins Journal of Biological Chemistry 2012 287:24534-24543 DOI:10.1074/jbc.M112.380139 PMID:22645132 PMCID:PMC3397878
- Moeller, A., Zhao, C. X., Fried, M. G., Wilson-Kubalek, E. M., Carragher, B., Whiteheart, S. W. Nucleotide-dependent conformational changes in the n-ethylmaleimide sensitive factor (nsf) and their potential role in snare complex disassembly Journal of Structural Biology 2012 177:335-343 DOI:10.1016/j.jsb.2011.12.018 PMID:22245547 PMCID:PMC3382979
- Schmidt, J. C., Arthanari, H., Boeszoermenyi, A., Dashkevich, N. M., Wilson-Kubalek, E. M., Monnier, N., Markus, M., Oberer, M., Milligan, R. A., Bathe, M., Wagner, G., Grishchuk, E. L., et al. The kinetochore-bound Ska1 complex tracks depolymerizing microtubules and binds to curved protofilaments Developmental Cell 2012 23:968-980 DOI:10.1016/j.devcel.2012.09.012 PMID:23085020 PMCID:PMC3500403
- Vadia, S., Arnett, E., Haghighat, A. C., Wilson-Kubalek, E. M., Tweten, R. K., Seveau, S. The pore-forming toxin listeriolysin O mediates a novel entry pathway of L. monocytogenes into human hepatocytes PLoS Pathogens 2011 7 DOI:10.1371/journal.ppat.1002356 PMID:22072970 PMCID:PMC3207921
- Wilson-Kubalek, E. M., Chappie, J. S., Arthur, C. P. Helical crystallization of soluble and membrane binding proteins Methods in Enzymology 2010 481:45-62 DOI:10.1016/s0076-6879(10)81002-x PMID:20887852
- Subramanian, R., Wilson-Kubalek, E. M., Arthur, C. P., Bick, M. J., Campbell, E. A., Darst, S. A., Milligan, R. A., Kapoor, T. M. Insights into antiparallel microtubule crosslinking by PRC1, a conserved nonmotor microtubule binding protein Cell 2010 142:433-443 DOI:10.1016/j.cell.2010.07.012 PMID:20691902 PMCID:PMC2966277
- Welburn, J. P. I., Grishchuk, E. L., Backer, C. B., Wilson-Kubalek, E. M., Yates, J. R., Cheeseman, I. M. The human kinetochore Ska1 complex facilitates microtubule depolymerization-coupled motility Developmental Cell 2009 16:374-385 DOI:10.1016/j.devcel.2009.01.011 PMID:19289083 PMCID:PMC2746561
- Wilson-Kubalek, E. M., Cheeseman, I. M., Yoshioka, C., Desai, A., Milligan, R. A. Orientation and structure of the Ndc80 complex on the microtubule lattice Journal of Cell Biology 2008 182:1055-1061 DOI:10.1083/jcb.200804170 PMID:18794333 PMCID:PMC2542468
- Carter, A. P., Garbarino, J. E., Wilson-Kubalek, E. M., Shipley, W. E., Cho, C., Milligan, R. A., Vale, R. D., Gibbons, I. R. Structure and functional role of dynein's microtubule-binding domain Science 2008 322:1691-1695 DOI:10.1126/science.1164424 PMID:19074350 PMCID:PMC2663340
- Suzuki, S., Wilson-Kubalek, E. M., Wert, D., Tsao, T. S., Lee, D. H. The oligomeric structure of high molecular weight adiponectin FEBS Letters 2007 581:809-814 DOI:10.1016/j.febslet.2007.01.046 PMID:17292892 PMCID:PMC1865574
- Kazmierczak, P., Sakaguchi, H., Tokita, J., Wilson-Kubalek, E. M., Milligan, R. A., Muller, U., Kachar, B. Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cells Nature 2007 449:87-91 DOI:10.1038/nature06091 PMID:17805295
- Cheeseman, I. M., Chappie, J. S., Wilson-Kubalek, E. M., Desai, A. The conserved KMN network constitutes the core microtubule-binding site of the kinetochore Cell 2006 127:983-997 DOI:10.1016/j.cell.2006.09.039 PMID:17129783
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Schuerch, D. W., Wilson-Kubalek, E. M., Tweten, R. K.
Molecular basis of listeriolysin O pH dependence
Proceedings of the National Academy of Sciences of the United States of America
2005
102:12537-12542
DOI:10.1073/pnas.0500558102
PMID:16105950
PMCID:PMC1194900
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Dang, T. X., Hotze, E. M., Rouiller, I., Tweten, R. K., Wilson-Kubalek, E. M.
Prepore to pore transition of a cholesterol-dependent cytolysin visualized by electron microscopy
Journal of Structural Biology
2005
150:100-108
DOI:10.1016/j.jsb.2005.02.003
PMID:15797734
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Dang, T. X., Farah, S. J., Gast, A., Robertson, C., Carragher, B., Egelman, E., Wilson-Kubalek, E. M.
Helical crystallization on lipid nanotubes: Streptavidin as a model protein
Journal of Structural Biology
2005
150:90-99
DOI:10.1016/j.jsb.2005.02.002
PMID:15797733
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Dang, T. X., Milligan, R. A., Tweten, R. K., Wilson-Kubalek, E. M.
Helical crystallization on nickel–lipid nanotubes: Perfringolysin O as a model protein
Journal of Structural Biology
2005
152:129-139
DOI:10.1016/j.jsb.2005.07.010
PMID:16242343
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Rouiller, I., DeLaBarre, B., May, A. P., Weis, W. I., Brunger, A. T., Milligan, R. A., Wilson-Kubalek, E. M.
Conformational changes of the multifunction p97 AAA ATPase during its ATPase cycle
Nature Structural Biology
2002
9:950-957
DOI:10.1038/nsb872
PMID:12434150
- Hotze, E. M., Wilson-Kubalek, E. M., Rossjohn, J., Parker, M. W., Johnson, A. E., Tweten, R. K. Arresting pore formation of a cholesterol-dependent cytolysin by disulfide trapping synchronizes the insertion of the transmembrane ss-sheet from a prepore intermediate Journal of Biological Chemistry 2001 276:8261-8268 DOI:10.1074/jbc.M009865200 PMID:11102453
- Avila-Sakar, A. J., Misaghi, S., Wilson-Kubalek, E. M., Downing, K. H., Zgurskaya, H., Nikaido, H., Nogales, E. Lipid-layer crystallization and preliminary three-dimensional structural analysis of AcrA, the periplasmic component of a bacterial multidrug efflux pump Journal of Structural Biology 2001 136:81-88 DOI:10.1006/jsbi.2001.4418 PMID:11858709
- Rouiller, I., Pulokas, J., Butel, V. M., Milligan, R. A., Wilson-Kubalek, E. M., Potter, C. S., Carragher, B. O. Automated image acquisition for single-particle reconstruction using p97 as the biological sample Journal of Structural Biology 2001 133:102-107 DOI:10.1006/jsbi.2001.4367 PMID:11472082
- Wilson-Kubalek, E. M. Preparation of functionalized lipid tubules for electron crystallography of macromolecules Methods in Enzymology 2000 312:515-519 DOI:10.1016/S0076-6879(00)12936-2 PMID:11070899
- Rouiller, I., Butel, V. M., Latterich, M., Milligan, R. A., Wilson-Kubalek, E. M. A major conformational change in p97 aaa atpase upon atp binding Molecular Cell 2000 6:1485-1490 DOI:10.1016/s1097-2765(00)00144-1 PMID:11163220
- Rice, S., Lin, A. W., Safer, D., Hart, C. L., Naber, N., Carragher, B. O., Cain, S. M., Pechatnikova, E., Wilson-Kubalek, E. M., Whittaker, M., Pate, E., Cooke, R., et al. A structural change in the kinesin motor protein that drives motility Nature 1999 402:778-784 DOI:10.1038/45483 PMID:10617199
- Celia, H., Wilson-Kubalek, E., Milligan, R. A., Teyton, L. Structure and function of a membrane-bound murine MHC class I molecule Proceedings of the National Academy of Sciences of the United States of America 1999 96:5634-5639 DOI:10.1073/pnas.96.10.5634 PMID:10318936 PMCID:PMC21912
- Wilson-Kubalek, E. M., Brown, R. E., Celia, H., Milligan, R. A. Lipid nanotubes as substrates for helical crystallization of macromolecules Proceedings of the National Academy of Sciences of the United States of America 1998 95:8040-8045 DOI:10.1073/pnas.95.14.8040 PMID:9653136
- Yeager, M., Wilson-Kubalek, E. M., Weiner, S. G., Brown, P. O., Rein, A. Supramolecular organization of immature and mature murine leukemia virus revealed by electron cryo-microscopy: implications for retroviral assembly mechanisms Proceedings of the National Academy of Sciences of the United States of America 1998 95:7299-7304 DOI:10.1073/pnas.95.13.7299 PMID:9636143 PMCID:PMC22596
- Sosa, H., Dias, D. P., Hoenger, A., Whittaker, M., Wilson-Kubalek, E., Sablin, E., Fletterick, R. J., Vale, R. D., Milligan, R. A. A model for the microtubule-Ncd motor protein complex obtained by cryo-electron microscopy and image analysis Cell 1997 90:217-224 DOI:10.1016/s0092-8674(00)80330-x PMID:9244296
- Jontes, J. D., Wilson-Kubalek, E. M., Milligan, R. A. A 32 degree tail swing in brush border myosin I on ADP release Nature 1995 378:751-753 DOI:10.1038/378751a0 PMID:7501027
- Whittaker, M., Wilson-Kubalek, E. M., Smith, J. E., Faust, L., Milligan, R. A., Sweeney, H. L. A 35-A movement of smooth muscle myosin on ADP release Nature 1995 378:748-751 DOI:10.1038/378748a0 PMID:7501026