recent publications
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academic article
- Raffeiner, P., Hart, J. R., Garcia-Caballero, D., Bar-Peled, L., Weinberg, M. S., Vogt, P. K. An MXD1-derived repressor peptide identifies noncoding mediators of MYC-driven cell proliferation Proceedings of the National Academy of Sciences of the United States of America 2020 117:6571-6579 DOI:10.1073/pnas.1921786117 PMID:32156728 PMCID:PMC7104257
- Pinto, D. O., Scott, T. A., DeMarino, C., Pleet, M. L., Vo, T. T., Saifuddin, M., Kovalskyy, D., Erickson, J., Cowen, M., Barclay, R. A., Zeng, C., Weinberg, M. S., et al. Effect of transcription inhibition and generation of suppressive viral non-coding RNAs Retrovirology 2019 16 DOI:10.1186/s12977-019-0475-0 PMID:31036006
- Zhou, J., Lazar, D., Li, H., Xia, X., Satheesan, S., Charlins, P., O'Mealy, D., Akkina, R., Saayman, S., Weinberg, M. S., Rossi, J. J., Morris, K. V. Receptor-targeted aptamer-siRNA conjugate-directed transcriptional regulation of HIV-1 Theranostics 2018 8:1575-1590 DOI:10.7150/thno.23085 PMID:29556342 PMCID:PMC5858168
- Shrivastava, S., Charlins, P., Ackley, A., Embree, H., Dropulic, B., Akkina, R., Weinberg, M. S., Morris, K. V. Stable transcriptional repression and parasitism of HIV-1 Molecular Therapy-Nucleic Acids 2018 12:12-18 DOI:10.1016/j.omtn.2018.04.011 PMID:30195752 PMCID:PMC6019856
- Dhar, N., Weinberg, M. S., Michod, R. E., Durand, P. M. Molecular trade-offs in RNA ligases affected the modular emergence of complex ribozymes at the origin of life Royal Society Open Science 2017 4 DOI:10.1098/rsos.170376 PMID:28989747 PMCID:PMC5627087
- van den Berg, F. T., Rossi, J. J., Arbuthnot, P., Weinberg, M. S. Design of effective primary microRNA mimics with different basal stem conformations Molecular Therapy-Nucleic Acids 2016 5 DOI:10.1038/mtna.2015.53 PMID:26756196 PMCID:PMC5012551
- Saayman, S. M., Ackley, A., Burdach, J., Clemson, M., Gruenert, D. C., Tachikawa, K., Chivukula, P., Weinberg, M. S., Morris, K. V. Long non-coding RNA BGas regulates the cystic fibrosis transmembrane conductance regulator Molecular Therapy 2016 24:1351-1357 DOI:10.1038/mt.2016.112 PMID:27434588 PMCID:PMC5023374
- Hart, J. R., Weinberg, M. S., Morris, K. V., Roberts, T. C., Janda, K. D., Garner, A. L., Vogt, P. K. MINCR is not a MYC-induced lncRNA Proceedings of the National Academy of Sciences of the United States of America 2016 113:E496-E497 DOI:10.1073/pnas.1519903113 PMID:26811502 PMCID:PMC4747730
- Saayman, S. M., Lazar, D. C., Scott, T. A., Hart, J. R., Takahashi, M., Burnett, J. C., Planelles, V., Morris, K. V., Weinberg, M. S. Potent and targeted activation of latent HIV-1 using the CRISPR/dCas9 activator complex Molecular Therapy 2016 24:488-498 DOI:10.1038/mt.2015.202 PMID:26581162 PMCID:PMC4786915
- Weinberg, M. S., Morris, K. V. Transcriptional gene silencing in humans Nucleic Acids Research 2016 44:6505-6517 DOI:10.1093/nar/gkw139 PMID:27060137
- Weinberg, M. S., Hart, J. R., Vogt, P. K. A brave new MYC-amplified world Aging 2015 7:459-460 PMID:26186937 PMCID:PMC4543031
- Zhou, J., Satheesan, S., Li, H., Weinberg, M. S., Morris, K. V., Burnett, J. C., Rossi, J. J. Cell-specific RNA aptamer against human CCR5 specifically targets HIV-1 susceptible cells and inhibits HIV-1 infectivity Chemistry & Biology 2015 22:379-390 DOI:10.1016/j.chembiol.2015.01.005 PMID:25754473 PMCID:PMC4369413
- Saayman, S., Roberts, T. C., Morris, K. V., Weinberg, M. S. HIV latency and the noncoding RNA therapeutic landscape Advances in Experimental Medicine and Biology 2015 848:169-189 DOI:10.1007/978-1-4939-2432-5_9 PMID:25757621
- Fok, E. T., Penny, C. B., Mhlanga, M. M., Weinberg, M. S. Multiplexed CRISPR/Cas9 genome editing increases the efficacy of homologous-dependent repair of donor sequences in mammalian cells South African Journal of Science 2015 111:60-66
- Roberts, T. C., Hart, J. R., Kaikkonen, M. U., Weinberg, M. S., Vogt, P. K., Morris, K. V. Quantification of nascent transcription by bromouridine immunocapture nuclear run-on RT-qPCR Nature Protocols 2015 10:1198-1211 DOI:10.1038/nprot.2015.076 PMID:26182239 PMCID:PMC4790731
- Saayman, S., Ali, S. A., Morris, K. V., Weinberg, M. S. The therapeutic application of CRISPR/Cas9 technologies for HIV Expert Opinion on Biological Therapy 2015 15:819-830 DOI:10.1517/14712598.2015.1036736 PMID:25865334 PMCID:PMC4581584
- Weinberg, M. S., Morris, K. V. A new world order: tailored gene targeting and regulation using CRISPR Molecular Therapy 2014 22:893-893 DOI:10.1038/mt.2014.54 PMID:24787973 PMCID:PMC4015226
- Hart, J. R., Roberts, T. C., Weinberg, M. S., Morris, K. V., Vogt, P. K. MYC regulates the non-coding transcriptome Oncotarget 2014 5:12543-12554 DOI:10.18632/oncotarget.3033 PMID:25587025 PMCID:PMC4350361
- Roberts, T. C., Morris, K. V., Weinberg, M. S. Perspectives on the mechanism of transcriptional regulation by long non-coding RNAs Epigenetics 2014 9:13-20 DOI:10.4161/epi.26700 PMID:24149621 PMCID:PMC3928176
- Da Costa Dias, B., Jovanovic, K., Gonsalves, D., Moodley, K., Reusch, U., Knackmuss, S., Weinberg, M. S., Little, M., Weiss, S. F. T. The 37kDa/67kDa laminin receptor acts as a receptor for Aβ42 internalization Scientific Reports 2014 4:5556 DOI:10.1038/srep05556 PMID:24990253 PMCID:PMC4080222
- Weinberg, M. S. Therapeutic aptamers march on Molecular Therapy-Nucleic Acids 2014 3:e194 DOI:10.1038/mtna.2014.46 PMID:25226163 PMCID:PMC4222651
- Jovanovic, K., Gonsalves, D., Da Costa Dias, B., Moodley, K., Reusch, U., Knackmuss, S., Penny, C., Weinberg, M. S., Little, M., Weiss, S. F. T. Anti-LRP/LR specific antibodies and shRNAs impede amyloid beta shedding in Alzheimer's disease Scientific Reports 2013 3:2699 DOI:10.1038/srep02699 PMID:24048412 PMCID:PMC3776966
- Da Costa Dias, B., Jovanovic, K., Gonsalves, D., Moodley, K., Reusch, U., Knackmuss, S., Penny, C., Weinberg, M. S., Little, M., Weiss, S. F. T. Anti-LRP/LR specific antibody IgG1-iS18 and knock-down of LRP/LR by shRNAs rescue cells from A beta(42) induced cytotoxicity Scientific Reports 2013 3:2702 DOI:10.1038/srep02702 PMID:24048171 PMCID:PMC3776967
- Da Costa Dias, B., Jovanovic, K., Gonsalves, D., Moodley, K., Reusch, U., Knackmuss, S., Penny, C., Weinberg, M. S., Little, M., Weiss, S. F. T. Anti-LRP/LR specific antibody IgG1-iS18 and knock-down of LRP/LR by shRNAs rescue cells from Aβ42 induced cytotoxicity Scientific Reports 2013 3:2702 DOI:10.1038/srep02702 PMID:24048171 PMCID:PMC3776967
- Fanucchi, S., Shibayama, Y., Burd, S., Weinberg, M. S., Mhlanga, M. M. Chromosomal contact permits transcription between coregulated genes Cell 2013 155:606-620 DOI:10.1016/j.cell.2013.09.051 PMID:24243018
- Weinberg, M. S., Morris, K. V. Long non-coding RNA targeting and transcriptional de-repression Nucleic Acid Therapeutics 2013 23:9-14 DOI:10.1089/nat.2012.0412 PMID:23391414 PMCID:PMC3569965
- Li, J., Weinberg, M. S., Zerbini, L., Prince, S. The oncogenic TBX3 is a downstream target and mediator of the TGF-β1 signaling pathway Molecular Biology of the Cell 2013 24:3569-3576 DOI:10.1091/mbc.E13-05-0273 PMID:24025717 PMCID:PMC3826994
- Taylor, S. H., Harmse, J., Arbuthnot, P., Van den Berg, F., Weinberg, M. S., Rey, M. E. C. Construction of effective inverted repeat silencing constructs using sodium bisulfite treatment coupled with strand-specific PCR Biotechniques 2012 52:254-262 DOI:10.2144/0000113839 PMID:22482441
- Green, V. A., Arbuthnot, P., Weinberg, M. S. Impact of sustained RNAi-mediated suppression of cellular cofactor Tat-SF1 on HIV-1 replication in CD4+T cells Virology Journal 2012 9:272 DOI:10.1186/1743-422x-9-272 PMID:23153325 PMCID:PMC3511259
- Scott, T., Paweska, J. T., Arbuthnot, P., Weinberg, M. S. Pathogenic effects of Rift Valley fever virus NSs gene are alleviated in cultured cells by expressed antiviral short hairpin RNAs Antiviral Therapy 2012 17:643-656 DOI:10.3851/imp2073 PMID:22345363
- Sibley, C. R., Seow, Y., Curtis, H., Weinberg, M. S., Wood, M. J. A. Silencing of Parkinson's disease-associated genes with artificial mirtron mimics of miR-1224 Nucleic Acids Research 2012 40:9863-9875 DOI:10.1093/nar/gks712 PMID:22848108 PMCID:PMC3479180
- Sibley, C. R., Seow, Y., Saayman, S., Dijkstra, K. K., El Andaloussi, S., Weinberg, M. S., Wood, M. J. A. The biogenesis and characterization of mammalian microRNAs of mirtron origin Nucleic Acids Research 2012 40:438-448 DOI:10.1093/nar/gkr722 PMID:21914725 PMCID:PMC3245937
- Green, V. A., Weinberg, M. S. Small RNA-induced transcriptional gene regulation in mammals mechanisms, therapeutic applications, and scope within the genome Progress in Molecular Biology and Translational Science 2011 102:11-46 DOI:10.1016/b978-0-12-415795-8.00005-2 PMID:21846568
- Saayman, S., Arbuthnot, P., Weinberg, M. S. Deriving four functional anti-HIV siRNAs from a single Pol III-generated transcript comprising two adjacent long hairpin RNA precursors Nucleic Acids Research 2010 38:6652-6663 DOI:10.1093/nar/gkq460 PMID:20525791 PMCID:PMC2965221
- Saayman, S. M., Arbuthnot, P., Weinberg, M. S. Effective Pol III-expressed long hairpin RNAs targeted to multiple unique sites of HIV-1 Methods in Molecular Biology 2010 629:159-174 DOI:10.1007/978-1-60761-657-3_11 PMID:20387149
- Hean, J., Crowther, C., Ely, A., Ul Islam, R., Barichievy, S., Bloom, K., Weinberg, M. S., van Otterlo, W. A., de Koning, C. B., Salazar, F., Marion, P., Roesch, E. B., et al. Inhibition of hepatitis B virus replication in vivo using lipoplexes containing altritol-modified antiviral siRNAs Artificial DNA, PNA & XNA 2010 1:17-26 DOI:10.4161/adna.1.1.11981 PMID:21687523 PMCID:PMC3109439
- Weinberg, M. S., Arbuthnot, P. Progress in the use of RNA interference as a therapy for chronic hepatitis B virus infection Genome Medicine 2010 2:28 DOI:10.1186/gm149 PMID:20429960 PMCID:PMC2873806
- Weinberg, M.S., van den Berg, F. RNAi-based therapies for the treatment of HIV European Pharmaceutical Review 2010 15:33-37
- Dyer, V., Ely, A., Bloom, K., Weinberg, M., Arbuthnot, P. tRNA(LYs3) promoter cassettes that efficiently express RNAi-activating antihepatitis B virus short hairpin RNAs Biochemical and Biophysical Research Communications 2010 398:640-646 DOI:10.1016/j.bbrc.2010.06.122 PMID:20599752
- Scholefield, J., Greenberg, L. J., Weinberg, M. S., Arbuthnot, P. B., Abdelgany, A., Wood, M. J. A. Design of RNAi hairpins for mutation-specific silencing of ataxin-7 and correction of a SCA7 phenotype PLoS One 2009 4 DOI:10.1371/journal.pone.0007232 PMID:19789634 PMCID:PMC2747278
- Arbuthnot, P., Ely, A., Weinberg, M. S. Hepatic delivery of RNA interference activators for therapeutic application Current Gene Therapy 2009 9:91-103 PMID:19355867
- Chattopadhyay, S., Ely, A., Bloom, K., Weinberg, M. S., Arbuthnot, P. Inhibition of hepatitis B virus replication with linear DNA sequences expressing antiviral micro-RNA shuttles Biochemical and Biophysical Research Communications 2009 389:484-489 DOI:10.1016/j.bbrc.2009.09.004 PMID:19733548
- Barichievy, S., Saayman, S., Arbuthnot, P., Weinberg, M. S. RNA interference-based gene expression strategies aimed at sustained therapeutic inhibition of HIV Current Topics in Medicinal Chemistry 2009 9:1065-1078 PMID:19860707
- Weinberg, M. S., Wood, M. J. Short non-coding RNA biology and neurodegenerative disorders: novel disease targets and therapeutics Human Molecular Genetics 2009 18:R27-R39 DOI:10.1093/hmg/ddp070 PMID:19297399 PMCID:PMC2657944
- Saayman, S., Barichievy, S., Capovilla, A., Morris, K. V., Arbuthnot, P., Weinberg, M. S. The efficacy of generating three independent anti-HIV-1 siRNAs from a single U6 RNA Pol III-expressed long hairpin RNA PLoS One 2008 3:e2602 DOI:10.1371/journal.pone.0002602 PMID:18596982 PMCID:PMC2434202
- Weinberg, M. S., Barichievy, S., Schaffer, L., Han, J., Morris, K. V. An RNA targeted to the HIV-1 LTR promoter modulates indiscriminate off-target gene activation Nucleic Acids Research 2007 35:7303-7312 DOI:10.1093/nar/gkm847 PMID:17959645 PMCID:PMC2175361
- Weinberg, M. S., Ely, A., Passman, M., Mufamadi, S. M., Arbuthnot, P. Effective anti-hepatitis B virus hammerhead ribozymes derived from multimeric precursors Oligonucleotides 2007 17:104-112 DOI:10.1089/oli.2006.0049 PMID:17461767
- Arbuthnot, P., Longshaw, V., Naidoo, T., Weinberg, M. S. Opportunities for treating chronic hepatitis B and C virus infection using RNA interference Journal of Viral Hepatitis 2007 14:447-459 DOI:10.1111/j.1365-2893.2006.00818.x PMID:17576386
- Scherer, L., Rossi, J. J., Weinberg, M. S. Progress and prospects: RNA-based therapies for treatment of HIV infection Gene Therapy 2007 14:1057-1064 DOI:10.1038/sj.gt.3302977 PMID:17607313
- Weinberg, M. S., Ely, A., Barichievy, S., Crowther, C., Mufamadi, S., Carmona, S., Arbuthnot, P. Specific inhibition of HBV replication in vitro and in vivo with expressed long hairpin RNA Molecular Therapy 2007 15:534-541 DOI:10.1038/sj.mt.6300077 PMID:17213835
- Barichievy, S., Saayman, S., Von Eije, K. J., Morris, K. V., Arbuthnot, P., Weinberg, M. S. The inhibitory efficacy of RNA POL III-Expressed long hairpin RNAs targeted to untranslated regions of the HIV-1 5' long terminal repeat Oligonucleotides 2007 17:419-431 DOI:10.1089/oli.2007.0095 PMID:17896874
- Weinberg, M. S., Morris, K. V. Are viral-encoded microRNAs mediating latent HIV-1 infection? DNA and Cell Biology 2006 25:223-231 DOI:10.1089/dna.2006.25.223 PMID:16629595 PMCID:PMC2861419
- Weinberg, M. S., Morris, K. V. Are viral-encoded microRNAs mediating latent HIV-1 infection? DNA and Cell Biology 2006 25:223-231 DOI:10.1089/dna.2006.25.223 PMID:16629595 PMCID:PMC2861419
- Carmona, S., Ely, A., Crowther, C., Moolla, N., Salazar, F. H., Marion, P. L., Ferry, N., Weinberg, M. S., Arbuthnot, P. Effective inhibition of HBV replication in vivo by anti-HBx short hairpin RNAs Molecular Therapy 2006 13:411-421 DOI:10.1016/j.ymthe.2005.10.013 PMID:16337206
- Cave, E., Weinberg, M. S., Cilliers, T., Carmona, S., Morris, L., Arbuthnot, P. Silencing of HIV-1 subtype C primary isolates by expressed small hairpin RNAs targeted to gag AIDS Research and Human Retroviruses 2006 22:401-410 DOI:10.1089/aid.2006.22.401 PMID:16706616
- Weinberg, M. S., Villeneuve, L. M., Ehsani, A., Amarzguioui, M., Aagaard, L., Chen, Z. X., Riggs, A. D., Rossi, J. J., Morris, K. V. The antisense strand of small interfering RNAs directs histone methylation and transcriptional gene silencing in human cells RNA-a Publication of the RNA Society 2006 12:256-262 DOI:10.1261/rna.2235106 PMID:16373483 PMCID:PMC1370905
- Weinberg, M. S., Rossi, J. J. Comparative single-turnover kinetic analyses of trans-cleaving hammerhead ribozymes with naturally derived non-conserved sequence motifs FEBS Letters 2005 579:1619-1624 DOI:10.1016/j.febslet.2005.02.016 PMID:15757651
- Weinberg, M., Passman, M., Kew, M., Arbuthnot, P. Hammerhead ribozyme-mediated inhibition of hepatitis B virus X gene expression in cultured cells Journal of Hepatology 2000 33:142-151 DOI:10.1016/s0168-8278(00)80171-3 PMID:10905598
- Passman, M., Weinberg, M., Kew, M., Arbuthnot, P. In situ demonstration of inhibitory effects of hammerhead ribozymes that are targeted to the hepatitis Bx sequence in cultured cells Biochemical and Biophysical Research Communications 2000 268:728-733 DOI:10.1006/bbrc.2000.2209 PMID:10679273
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book
- Berkhout, B., Ertl, H. C. J., Weinberg, M. S. Gene therapy for HIV and chronic infections Advances in Experimental Medicine and Biology Ed. Berkhout, B.. Springer. 2015
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chapter
- Green, V. A., Weinberg, M. S. Small RNA-induced transcriptional gene regulation in mammals mechanisms, therapeutic applications, and scope within the genome Cellular RNA interference mechanisms. 11-46. 2011 DOI:10.1016/b978-0-12-415795-8.00005-2
