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Weinberg, Marc
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Weinberg, Marc

Faculty Member Adjunct
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Positions

  • 2017 - Assistant Professor Adjunct, Molecular Medicine , Scripps Research
  • 2010 - Associate Professor, Department of Molecular Medicine and Haematology, University of the Witwatersrand
  • 2016 - 2017 Assistant Professor Adjunct, Molecular and Experimental Medicine (MEM) , Scripps Research
  • 2015 - 2016 Assistant Professor of Molecular Therapeutics, Molecular and Experimental Medicine (MEM) , Scripps Research
  • 2012 - 2015 Senior Staff Scientist, Molecular and Experimental Medicine (MEM) , Scripps Research
  • 2008 - 2012 Visiting Lecturer, Department of Physiology, Anatomy and Genetics, University of Oxford
  • 2006 - 2010 Senior Lecturer, Department of Molecular Medicine and Haematology, University of the Witwatersrand
  • 2002 - 2006 Lecturer, Department of Molecular Medicine and Haematology, University of the Witwatersrand
  • 2003 - 2005 James Gear Postdoctoral Fellow, Beckman Research Institute, City of Hope
  • 1999 - 2002 Associate Lecturer, Department of Molecular Medicine and Haematology, University of the Witwatersrand

Contact

  • marcow@scripps.edu

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Publications

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  • academic article

    • Raffeiner, P., Hart, J. R., Garcia-Caballero, D., Bar-Peled, L., Weinberg, M. S., Vogt, P. K. An MXD1-derived repressor peptide identifies noncoding mediators of MYC-driven cell proliferation Proceedings of the National Academy of Sciences of the United States of America  2020 117:6571-6579  DOI:10.1073/pnas.1921786117  PMID:32156728  PMCID:PMC7104257
    • Pinto, D. O., Scott, T. A., DeMarino, C., Pleet, M. L., Vo, T. T., Saifuddin, M., Kovalskyy, D., Erickson, J., Cowen, M., Barclay, R. A., Zeng, C., Weinberg, M. S., et al. Effect of transcription inhibition and generation of suppressive viral non-coding RNAs Retrovirology  2019 16  DOI:10.1186/s12977-019-0475-0  PMID:31036006
    • Shrivastava, S., Charlins, P., Ackley, A., Embree, H., Dropulic, B., Akkina, R., Weinberg, M. S., Morris, K. V. Stable transcriptional repression and parasitism of HIV-1 Molecular Therapy-Nucleic Acids  2018 12:12-18  DOI:10.1016/j.omtn.2018.04.011  PMID:30195752  PMCID:PMC6019856
    • Zhou, J., Lazar, D., Li, H., Xia, X., Satheesan, S., Charlins, P., O'Mealy, D., Akkina, R., Saayman, S., Weinberg, M. S., Rossi, J. J., Morris, K. V. Receptor-targeted aptamer-siRNA conjugate-directed transcriptional regulation of HIV-1 Theranostics  2018 8:1575-1590  DOI:10.7150/thno.23085  PMID:29556342  PMCID:PMC5858168
    • Dhar, N., Weinberg, M. S., Michod, R. E., Durand, P. M. Molecular trade-offs in RNA ligases affected the modular emergence of complex ribozymes at the origin of life Royal Society Open Science  2017 4  DOI:10.1098/rsos.170376  PMID:28989747  PMCID:PMC5627087
    • Weinberg, M. S., Morris, K. V. Transcriptional gene silencing in humans Nucleic Acids Research  2016 44:6505-6517  DOI:10.1093/nar/gkw139  PMID:27060137
    • Saayman, S. M., Ackley, A., Burdach, J., Clemson, M., Gruenert, D. C., Tachikawa, K., Chivukula, P., Weinberg, M. S., Morris, K. V. Long non-coding RNA BGas regulates the cystic fibrosis transmembrane conductance regulator Molecular Therapy  2016 24:1351-1357  DOI:10.1038/mt.2016.112  PMID:27434588  PMCID:PMC5023374
    • Saayman, S. M., Lazar, D. C., Scott, T. A., Hart, J. R., Takahashi, M., Burnett, J. C., Planelles, V., Morris, K. V., Weinberg, M. S. Potent and targeted activation of latent HIV-1 using the CRISPR/dCas9 activator complex Molecular Therapy  2016 24:488-498  DOI:10.1038/mt.2015.202  PMID:26581162  PMCID:PMC4786915
    • Hart, J. R., Weinberg, M. S., Morris, K. V., Roberts, T. C., Janda, K. D., Garner, A. L., Vogt, P. K. MINCR is not a MYC-induced lncRNA Proceedings of the National Academy of Sciences of the United States of America  2016 113:E496-E497  DOI:10.1073/pnas.1519903113  PMID:26811502  PMCID:PMC4747730
    • van den Berg, F. T., Rossi, J. J., Arbuthnot, P., Weinberg, M. S. Design of effective primary microRNA mimics with different basal stem conformations Molecular Therapy-Nucleic Acids  2016 5  DOI:10.1038/mtna.2015.53  PMID:26756196  PMCID:PMC5012551
    • Roberts, T. C., Hart, J. R., Kaikkonen, M. U., Weinberg, M. S., Vogt, P. K., Morris, K. V. Quantification of nascent transcription by bromouridine immunocapture nuclear run-on RT-qPCR Nature Protocols  2015 10:1198-1211  DOI:10.1038/nprot.2015.076  PMID:26182239  PMCID:PMC4790731
    • Weinberg, M. S., Hart, J. R., Vogt, P. K. A brave new MYC-amplified world Aging  2015 7:459-460  PMID:26186937  PMCID:PMC4543031
    • Fok, E. T., Penny, C. B., Mhlanga, M. M., Weinberg, M. S. Multiplexed CRISPR/Cas9 genome editing increases the efficacy of homologous-dependent repair of donor sequences in mammalian cells South African Journal of Science  2015 111:60-66
    • Saayman, S., Ali, S. A., Morris, K. V., Weinberg, M. S. The therapeutic application of CRISPR/Cas9 technologies for HIV Expert Opinion on Biological Therapy  2015 15:819-830  DOI:10.1517/14712598.2015.1036736  PMID:25865334  PMCID:PMC4581584
    • Zhou, J., Satheesan, S., Li, H., Weinberg, M. S., Morris, K. V., Burnett, J. C., Rossi, J. J. Cell-specific RNA aptamer against human CCR5 specifically targets HIV-1 susceptible cells and inhibits HIV-1 infectivity Chemistry & Biology  2015 22:379-390  DOI:10.1016/j.chembiol.2015.01.005  PMID:25754473  PMCID:PMC4369413
    • Saayman, S., Roberts, T. C., Morris, K. V., Weinberg, M. S. HIV latency and the noncoding RNA therapeutic landscape Advances in Experimental Medicine and Biology  2015 848:169-189  DOI:10.1007/978-1-4939-2432-5_9  PMID:25757621
    • Hart, J. R., Roberts, T. C., Weinberg, M. S., Morris, K. V., Vogt, P. K. MYC regulates the non-coding transcriptome Oncotarget  2014 5:12543-12554  DOI:10.18632/oncotarget.3033  PMID:25587025  PMCID:PMC4350361
    • Weinberg, M. S. Therapeutic aptamers march on Molecular Therapy-Nucleic Acids  2014 3:e194  DOI:10.1038/mtna.2014.46  PMID:25226163  PMCID:PMC4222651
    • Weinberg, M. S., Morris, K. V. A new world order: tailored gene targeting and regulation using CRISPR Molecular Therapy  2014 22:893-893  DOI:10.1038/mt.2014.54  PMID:24787973  PMCID:PMC4015226
    • Roberts, T. C., Morris, K. V., Weinberg, M. S. Perspectives on the mechanism of transcriptional regulation by long non-coding RNAs Epigenetics  2014 9:13-20  DOI:10.4161/epi.26700  PMID:24149621  PMCID:PMC3928176
    • Da Costa Dias, B., Jovanovic, K., Gonsalves, D., Moodley, K., Reusch, U., Knackmuss, S., Weinberg, M. S., Little, M., Weiss, S. F. T. The 37kDa/67kDa laminin receptor acts as a receptor for Aβ42 internalization Scientific Reports  2014 4:5556  DOI:10.1038/srep05556  PMID:24990253  PMCID:PMC4080222
    • Li, J., Weinberg, M. S., Zerbini, L., Prince, S. The oncogenic TBX3 is a downstream target and mediator of the TGF-β1 signaling pathway Molecular Biology of the Cell  2013 24:3569-3576  DOI:10.1091/mbc.E13-05-0273  PMID:24025717  PMCID:PMC3826994
    • Fanucchi, S., Shibayama, Y., Burd, S., Weinberg, M. S., Mhlanga, M. M. Chromosomal contact permits transcription between coregulated genes Cell  2013 155:606-620  DOI:10.1016/j.cell.2013.09.051  PMID:24243018
    • Jovanovic, K., Gonsalves, D., Da Costa Dias, B., Moodley, K., Reusch, U., Knackmuss, S., Penny, C., Weinberg, M. S., Little, M., Weiss, S. F. T. Anti-LRP/LR specific antibodies and shRNAs impede amyloid beta shedding in Alzheimer's disease Scientific Reports  2013 3:2699  DOI:10.1038/srep02699  PMID:24048412  PMCID:PMC3776966
    • Weinberg, M. S., Morris, K. V. Long non-coding RNA targeting and transcriptional de-repression Nucleic Acid Therapeutics  2013 23:9-14  DOI:10.1089/nat.2012.0412  PMID:23391414  PMCID:PMC3569965
    • Da Costa Dias, B., Jovanovic, K., Gonsalves, D., Moodley, K., Reusch, U., Knackmuss, S., Penny, C., Weinberg, M. S., Little, M., Weiss, S. F. T. Anti-LRP/LR specific antibody IgG1-iS18 and knock-down of LRP/LR by shRNAs rescue cells from A beta(42) induced cytotoxicity Scientific Reports  2013 3:2702  DOI:10.1038/srep02702  PMID:24048171  PMCID:PMC3776967
    • Da Costa Dias, B., Jovanovic, K., Gonsalves, D., Moodley, K., Reusch, U., Knackmuss, S., Penny, C., Weinberg, M. S., Little, M., Weiss, S. F. T. Anti-LRP/LR specific antibody IgG1-iS18 and knock-down of LRP/LR by shRNAs rescue cells from Aβ42 induced cytotoxicity Scientific Reports  2013 3:2702  DOI:10.1038/srep02702  PMID:24048171  PMCID:PMC3776967
    • Green, V. A., Arbuthnot, P., Weinberg, M. S. Impact of sustained RNAi-mediated suppression of cellular cofactor Tat-SF1 on HIV-1 replication in CD4+T cells Virology Journal  2012 9:272  DOI:10.1186/1743-422x-9-272  PMID:23153325  PMCID:PMC3511259
    • Sibley, C. R., Seow, Y., Curtis, H., Weinberg, M. S., Wood, M. J. A. Silencing of Parkinson's disease-associated genes with artificial mirtron mimics of miR-1224 Nucleic Acids Research  2012 40:9863-9875  DOI:10.1093/nar/gks712  PMID:22848108  PMCID:PMC3479180
    • Taylor, S. H., Harmse, J., Arbuthnot, P., Van den Berg, F., Weinberg, M. S., Rey, M. E. C. Construction of effective inverted repeat silencing constructs using sodium bisulfite treatment coupled with strand-specific PCR Biotechniques  2012 52:254-262  DOI:10.2144/0000113839  PMID:22482441
    • Scott, T., Paweska, J. T., Arbuthnot, P., Weinberg, M. S. Pathogenic effects of Rift Valley fever virus NSs gene are alleviated in cultured cells by expressed antiviral short hairpin RNAs Antiviral Therapy  2012 17:643-656  DOI:10.3851/imp2073  PMID:22345363
    • Sibley, C. R., Seow, Y., Saayman, S., Dijkstra, K. K., El Andaloussi, S., Weinberg, M. S., Wood, M. J. A. The biogenesis and characterization of mammalian microRNAs of mirtron origin Nucleic Acids Research  2012 40:438-448  DOI:10.1093/nar/gkr722  PMID:21914725  PMCID:PMC3245937
    • Green, V. A., Weinberg, M. S. Small RNA-induced transcriptional gene regulation in mammals mechanisms, therapeutic applications, and scope within the genome Progress in Molecular Biology and Translational Science  2011 102:11-46  DOI:10.1016/b978-0-12-415795-8.00005-2  PMID:21846568
    • Saayman, S., Arbuthnot, P., Weinberg, M. S. Deriving four functional anti-HIV siRNAs from a single Pol III-generated transcript comprising two adjacent long hairpin RNA precursors Nucleic Acids Research  2010 38:6652-6663  DOI:10.1093/nar/gkq460  PMID:20525791  PMCID:PMC2965221
    • Dyer, V., Ely, A., Bloom, K., Weinberg, M., Arbuthnot, P. tRNA(LYs3) promoter cassettes that efficiently express RNAi-activating antihepatitis B virus short hairpin RNAs Biochemical and Biophysical Research Communications  2010 398:640-646  DOI:10.1016/j.bbrc.2010.06.122  PMID:20599752
    • Saayman, S. M., Arbuthnot, P., Weinberg, M. S. Effective Pol III-expressed long hairpin RNAs targeted to multiple unique sites of HIV-1 Methods in Molecular Biology  2010 629:159-174  DOI:10.1007/978-1-60761-657-3_11  PMID:20387149
    • Hean, J., Crowther, C., Ely, A., Ul Islam, R., Barichievy, S., Bloom, K., Weinberg, M. S., van Otterlo, W. A., de Koning, C. B., Salazar, F., Marion, P., Roesch, E. B., et al. Inhibition of hepatitis B virus replication in vivo using lipoplexes containing altritol-modified antiviral siRNAs Artificial DNA, PNA & XNA  2010 1:17-26  DOI:10.4161/adna.1.1.11981  PMID:21687523  PMCID:PMC3109439
    • Weinberg, M. S., Arbuthnot, P. Progress in the use of RNA interference as a therapy for chronic hepatitis B virus infection Genome Medicine  2010 2:28  DOI:10.1186/gm149  PMID:20429960  PMCID:PMC2873806
    • Weinberg, M.S., van den Berg, F. RNAi-based therapies for the treatment of HIV European Pharmaceutical Review  2010 15:33-37
    • Chattopadhyay, S., Ely, A., Bloom, K., Weinberg, M. S., Arbuthnot, P. Inhibition of hepatitis B virus replication with linear DNA sequences expressing antiviral micro-RNA shuttles Biochemical and Biophysical Research Communications  2009 389:484-489  DOI:10.1016/j.bbrc.2009.09.004  PMID:19733548
    • Scholefield, J., Greenberg, L. J., Weinberg, M. S., Arbuthnot, P. B., Abdelgany, A., Wood, M. J. A. Design of RNAi hairpins for mutation-specific silencing of ataxin-7 and correction of a SCA7 phenotype PLoS One  2009 4  DOI:10.1371/journal.pone.0007232  PMID:19789634  PMCID:PMC2747278
    • Barichievy, S., Saayman, S., Arbuthnot, P., Weinberg, M. S. RNA interference-based gene expression strategies aimed at sustained therapeutic inhibition of HIV Current Topics in Medicinal Chemistry  2009 9:1065-1078  PMID:19860707
    • Weinberg, M. S., Wood, M. J. Short non-coding RNA biology and neurodegenerative disorders: novel disease targets and therapeutics Human Molecular Genetics  2009 18:R27-R39  DOI:10.1093/hmg/ddp070  PMID:19297399  PMCID:PMC2657944
    • Arbuthnot, P., Ely, A., Weinberg, M. S. Hepatic delivery of RNA interference activators for therapeutic application Current Gene Therapy  2009 9:91-103  PMID:19355867
    • Saayman, S., Barichievy, S., Capovilla, A., Morris, K. V., Arbuthnot, P., Weinberg, M. S. The efficacy of generating three independent anti-HIV-1 siRNAs from a single U6 RNA Pol III-expressed long hairpin RNA PLoS One  2008 3:e2602  DOI:10.1371/journal.pone.0002602  PMID:18596982  PMCID:PMC2434202
    • Weinberg, M. S., Barichievy, S., Schaffer, L., Han, J., Morris, K. V. An RNA targeted to the HIV-1 LTR promoter modulates indiscriminate off-target gene activation Nucleic Acids Research  2007 35:7303-7312  DOI:10.1093/nar/gkm847  PMID:17959645  PMCID:PMC2175361
    • Barichievy, S., Saayman, S., Von Eije, K. J., Morris, K. V., Arbuthnot, P., Weinberg, M. S. The inhibitory efficacy of RNA POL III-Expressed long hairpin RNAs targeted to untranslated regions of the HIV-1 5' long terminal repeat Oligonucleotides  2007 17:419-431  DOI:10.1089/oli.2007.0095  PMID:17896874
    • Arbuthnot, P., Longshaw, V., Naidoo, T., Weinberg, M. S. Opportunities for treating chronic hepatitis B and C virus infection using RNA interference Journal of Viral Hepatitis  2007 14:447-459  DOI:10.1111/j.1365-2893.2006.00818.x  PMID:17576386
    • Scherer, L., Rossi, J. J., Weinberg, M. S. Progress and prospects: RNA-based therapies for treatment of HIV infection Gene Therapy  2007 14:1057-1064  DOI:10.1038/sj.gt.3302977  PMID:17607313
    • Weinberg, M. S., Ely, A., Barichievy, S., Crowther, C., Mufamadi, S., Carmona, S., Arbuthnot, P. Specific inhibition of HBV replication in vitro and in vivo with expressed long hairpin RNA Molecular Therapy  2007 15:534-541  DOI:10.1038/sj.mt.6300077  PMID:17213835
    • Weinberg, M. S., Ely, A., Passman, M., Mufamadi, S. M., Arbuthnot, P. Effective anti-hepatitis B virus hammerhead ribozymes derived from multimeric precursors Oligonucleotides  2007 17:104-112  DOI:10.1089/oli.2006.0049  PMID:17461767
    • Cave, E., Weinberg, M. S., Cilliers, T., Carmona, S., Morris, L., Arbuthnot, P. Silencing of HIV-1 subtype C primary isolates by expressed small hairpin RNAs targeted to gag AIDS Research and Human Retroviruses  2006 22:401-410  DOI:10.1089/aid.2006.22.401  PMID:16706616
    • Weinberg, M. S., Morris, K. V. Are viral-encoded microRNAs mediating latent HIV-1 infection? DNA and Cell Biology  2006 25:223-231  DOI:10.1089/dna.2006.25.223  PMID:16629595  PMCID:PMC2861419
    • Weinberg, M. S., Morris, K. V. Are viral-encoded microRNAs mediating latent HIV-1 infection? DNA and Cell Biology  2006 25:223-231  DOI:10.1089/dna.2006.25.223  PMID:16629595  PMCID:PMC2861419
    • Carmona, S., Ely, A., Crowther, C., Moolla, N., Salazar, F. H., Marion, P. L., Ferry, N., Weinberg, M. S., Arbuthnot, P. Effective inhibition of HBV replication in vivo by anti-HBx short hairpin RNAs Molecular Therapy  2006 13:411-421  DOI:10.1016/j.ymthe.2005.10.013  PMID:16337206
    • Weinberg, M. S., Villeneuve, L. M., Ehsani, A., Amarzguioui, M., Aagaard, L., Chen, Z. X., Riggs, A. D., Rossi, J. J., Morris, K. V. The antisense strand of small interfering RNAs directs histone methylation and transcriptional gene silencing in human cells RNA-a Publication of the RNA Society  2006 12:256-262  DOI:10.1261/rna.2235106  PMID:16373483  PMCID:PMC1370905
    • Weinberg, M. S., Rossi, J. J. Comparative single-turnover kinetic analyses of trans-cleaving hammerhead ribozymes with naturally derived non-conserved sequence motifs FEBS Letters  2005 579:1619-1624  DOI:10.1016/j.febslet.2005.02.016  PMID:15757651
    • Weinberg, M., Passman, M., Kew, M., Arbuthnot, P. Hammerhead ribozyme-mediated inhibition of hepatitis B virus X gene expression in cultured cells Journal of Hepatology  2000 33:142-151  DOI:10.1016/s0168-8278(00)80171-3  PMID:10905598
    • Passman, M., Weinberg, M., Kew, M., Arbuthnot, P. In situ demonstration of inhibitory effects of hammerhead ribozymes that are targeted to the hepatitis Bx sequence in cultured cells Biochemical and Biophysical Research Communications  2000 268:728-733  DOI:10.1006/bbrc.2000.2209  PMID:10679273
  • book

    • Berkhout, B., Ertl, H. C. J., Weinberg, M. S. Gene therapy for HIV and chronic infections Advances in Experimental Medicine and Biology Ed. Berkhout, B..  Springer. 2015
  • chapter

    • Green, V. A., Weinberg, M. S. Small RNA-induced transcriptional gene regulation in mammals mechanisms, therapeutic applications, and scope within the genome Cellular RNA interference mechanisms. 11-46. 2011  DOI:10.1016/b978-0-12-415795-8.00005-2
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Background

education and training

  • Ph.D. in Molecular Biology, University of the Witwatersrand 1997 - 2002
  • B.Sc. in Biochemistry, University of the Witwatersrand , B.Sc. Hons. awarded in 1996 1993 - 1995
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Contact

full name

  • Marc S. Weinberg

geographic location

  • Scripps California 
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Identity

ORCID iD

  • ORCID iD http://orcid.org/0000-0002-1997-2171

ResearcherID (Thomson Reuters)

  • B-4669-2009

Scopus ID

  • 35303792500

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