Ward, Andrew

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- van der Woude, R., Turner, H. L., Tomris, I., Bouwman, K. M., Ward, A. B., de Vries, R. P. Drivers of recombinant soluble influenza A virus hemagglutinin and neuraminidase expression in mammalian cells Protein Science 2020 29:1975-1982 DOI:10.1002/pro.3918 PMID:32710576 PMCID:PMC7454420
- Brouwer, P. J. M., Caniels, T. G., van der Straten, K., Snitselaar, J. L., Aldon, Y., Bangaru, S., Torres, J. L., Okba, N. M. A., Claireaux, M., Kerster, G., Bentlage, A. E. H., van Haaren, M. M., et al. Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability Science 2020 369:643-650 DOI:10.1126/science.abc5902 PMID:32540902 PMCID:PMC7299281
- Martin, J. T., Cottrell, C. A., Antanasijevic, A., Carnathan, D. G., Cossette, B. J., Enemuo, C. A., Gebru, E. H., Choe, Y., Viviano, F., Fischinger, S., Tokatlian, T., Cirelli, K. M., et al. Targeting HIV Env immunogens to B cell follicles in nonhuman primates through immune complex or protein nanoparticle formulations NPJ Vaccines 2020 5 DOI:10.1038/s41541-020-00223-1 PMID:32802411 PMCID:PMC7406516
- Seabright, G. E., Cottrell, C. A., van Gils, M. J., D'Addabbo, A., Harvey, D. J., Behrens, A. J., Allen, J. D., Watanabe, Y., Scaringi, N., Polveroni, T. M., Maker, A., Vasiljevic, S., et al. Networks of HIV-1 Envelope Glycans Maintain Antibody Epitopes in the Face of Glycan Additions and Deletions Structure 2020 28:897-906 DOI:10.1016/j.str.2020.04.022 PMID:32433992 PMCID:PMC7416112
- Ueda, G., Antanasijevic, A., Fallas, J. A., Sheffler, W., Copps, J., Ellis, D., Hutchinson, G. B., Moyer, A., Yasmeen, A., Tsybovsky, Y., Park, Y. J., Bick, M. J., et al. Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens eLife 2020 9 DOI:10.7554/eLife.57659 PMID:32748788 PMCID:PMC7402677
- Ellebedy, A. H., Nachbagauer, R., Jackson, K. J. L., Dai, Y. N., Han, J., Alsoussi, W. B., Davis, C. W., Stadlbauer, D., Rouphael, N., Chromikova, V., McCausland, M., Chang, C. Y., et al. Adjuvanted H5N1 influenza vaccine enhances both cross-reactive memory B cell and strain-specific naive B cell responses in humans Proceedings of the National Academy of Sciences of the United States of America 2020 117:17957-17964 DOI:10.1073/pnas.1906613117 PMID:32661157 PMCID:PMC7395544
- Carnathan, D. G., Kaushik, K., Ellebedy, A. H., Enemuo, C. A., Gebru, E. H., Dhadvai, P., Rasheed, M. A. U., Pauthner, M. G., Ozorowski, G., Ahmed, R., Burton, D. R., Ward, A. B., et al. Harnessing Activin A Adjuvanticity to Promote Antibody Responses to BG505 HIV Envelope Trimers Frontiers in Immunology 2020 11 DOI:10.3389/fimmu.2020.01213 PMID:32612608 PMCID:PMC7308430
- Nogal, B., McCoy, L. E., van Gils, M. J., Cottrell, C. A., Voss, J. E., Andrabi, R., Pauthner, M., Liang, C. H., Messmer, T., Nedellec, R., Shin, M., Turner, H. L., et al. HIV envelope trimer-elicited autologous neutralizing antibodies bind a region overlapping the N332 glycan supersite Science Advances 2020 6 DOI:10.1126/sciadv.aba0512 PMID:32548265 PMCID:PMC7274786
- Rantalainen, K., Berndsen, Z. T., Antanasijevic, A., Schiffner, T., Zhang, X., Lee, W. H., Torres, J. L., Zhang, L., Irimia, A., Copps, J., Zhou, K. H., Kwon, Y. D., et al. HIV-1 Envelope and MPER Antibody Structures in Lipid Assemblies Cell Reports 2020 31 DOI:10.1016/j.celrep.2020.107583 PMID:32348769 PMCID:PMC7196886
- Yang, Y. H. R., McCoy, L. E., van Gils, M. J., Andrabi, R., Turner, H. L., Yuan, M., Cottrell, C. A., Ozorowski, G., Voss, J., Pauthner, M., Polveroni, T. M., Messmer, T., et al. Autologous antibody responses to an HIV envelope glycan hole are not easily broadened in rabbits Journal of Virology 2020 94 DOI:10.1128/jvi.01861-19 PMID:31941772 PMCID:PMC7081899
- Ringe, R. P., Portillo, V. M. C., Dosenovic, P., Ketas, T. J., Ozorowski, G., Nogal, B., Perez, L., LaBranche, C. C., Lim, J., Francomano, E., Wilson, I. A., Sanders, R. W., et al. Neutralizing antibody induction by HIV-1 envelope glycoprotein SOSIP trimers on iron oxide nanoparticles may be impaired by mannose binding lectin Journal of Virology 2020 94 DOI:10.1128/jvi.01883-19 PMID:31852794
- Oyen, D., Torres, J. L., Aoto, P. C., Flores-Garcia, Y., Binter, S., Pholcharee, T., Carroll, S., Reponen, S., Wash, R., Liang, Q., King, C. R., Emerling, D., et al. Structure and mechanism of monoclonal antibody binding to the junctional epitope of Plasmodium falciparum circumsporozoite protein Plos Pathogens 2020 16 DOI:10.1371/journal.ppat.1008373 PMID:32150583 PMCID:PMC7082059
- Gilchuk, P., Murin, C. D., Milligan, J. C., Cross, R. W., Mire, C. E., Ilinykh, P. A., Huang, K., Kuzmina, N., Altman, P. X., Hui, S., Gunn, B. M., Bryan, A. L., et al. Analysis of a therapeutic antibody cocktail reveals determinants for cooperative and broad ebolavirus neutralization Immunity 2020 52:388-403 DOI:10.1016/j.immuni.2020.01.001 PMID:32023489
- Moyer, T. J., Kato, Y., Abraham, W., Chang, J. Y. H., Kulp, D. W., Watson, N., Turner, H. L., Menis, S., Abbott, R. K., Bhiman, J. N., Melo, M. B., Simon, H. A., et al. Engineered immunogen binding to alum adjuvant enhances humoral immunity Nature Medicine 2020 26:430-440 DOI:10.1038/s41591-020-0753-3 PMID:32066977 PMCID:PMC7069805
- Phoicharee, T., Oyen, D., Torres, J. L., Flores-Garcia, Y., Martin, G. M., Gonzalez-Paez, G. E., Emerling, D., Volkmuth, W., Locke, E., King, C. R., Zavala, F., Ward, A. B., et al. Diverse antibody responses to conserved structural motifs in plasmodium falciparum circumsporozoite protein Journal of Molecular Biology 2020 432:1048-1063 DOI:10.1016/j.jmb.2019.12.029 PMID:31883801 PMCID:PMC7057269
- Ozorowski, G., Torres, J. L., Santos-Martins, D., Forli, S., Ward, A. B. A Strain-Specific Inhibitor of Receptor-Bound HIV-1 Targets a Pocket near the Fusion Peptide Cell Reports 2020 33 DOI:10.1016/j.celrep.2020.108428 PMID:33238117 PMCID:PMC7701285
- Thrane, S., Aves, K. L., Uddback, I. E. M., Janitzek, C. M., Han, J., Yang, Y. R., Ward, A. B., Theander, T. G., Nielsen, M. A., Salanti, A., Thomsen, A. R., Christensen, J. P., et al. A Vaccine Displaying a Trimeric Influenza-A HA Stem Protein on Capsid-Like Particles Elicits Potent and Long-Lasting Protection in Mice Vaccines 2020 8 DOI:10.3390/vaccines8030389 PMID:32679905 PMCID:PMC7564254
- Wu, N. C., Yuan, M., Liu, H., Lee, C. C. D., Zhu, X., Bangaru, S., Torres, J. L., Caniels, T. G., Brouwer, P. J. M., van Gils, M. J., Sanders, R. W., Ward, A. B., et al. An Alternative Binding Mode of IGHV3-53 Antibodies to the SARS-CoV-2 Receptor Binding Domain Cell Reports 2020 33 DOI:10.1016/j.celrep.2020.108274 PMID:33027617 PMCID:PMC7522650
- Dong, J. H., Gilchuk, I., Li, S., Irving, R., Goff, M. T., Turner, H. L., Ward, A. B., Carnahan, R. H., Crowe, J. E. Anti-influenza H7 human antibody targets antigenic site in hemagglutinin head domain interface Journal of Clinical Investigation 2020 130:4734-4739 DOI:10.1172/jci136032 PMID:32749241 PMCID:PMC7456233
- Liu, H. J., Wu, N. C., Yuan, M., Bangaru, S., Torres, J. L., Caniels, T. G., van Schooten, J., Zhu, X. Y., Lee, C. C. D., Brouwer, P. J. M., van Gils, M. J., Sanders, R. W., et al. Cross-Neutralization of a SARS-CoV-2 Antibody to a Functionally Conserved Site Is Mediated by Avidity Immunity 2020 53:1272-1280 DOI:10.1016/j.immuni.2020.10.023 PMID:33242394 PMCID:PMC7687367
- Kefauver, J. M., Ward, A. B., Patapoutian, A. Discoveries in structure and physiology of mechanically activated ion channels Nature 2020 587:567-576 DOI:10.1038/s41586-020-2933-1 PMID:33239794
- Turner, J. S., Zhou, J. Q., Han, J., Schmitz, A. J., Rizk, A. A., Alsoussi, W. B., Lei, T. T., Amor, M., McIntire, K. M., Meade, P., Strohmeier, S., Brent, R. I., et al. Human germinal centres engage memory and naive B cells after influenza vaccination Nature 2020 586:127-132 DOI:10.1038/s41586-020-2711-0 PMID:32866963
- Ward, A. B., Wilson, I. A. Innovations in structure-based antigen design and immune monitoring for next generation vaccines Current Opinion in Immunology 2020 65:50-56 DOI:10.1016/j.coi.2020.03.013 PMID:32387642 PMCID:PMC7174181
- Zhao, F., Joyce, C., Burns, A., Nogal, B., Cottrell, C. A., Ramos, A., Biddle, T., Pauthner, M., Nedellec, R., Qureshi, H., Mason, R., Landais, E., et al. Mapping Neutralizing Antibody Epitope Specificities to an HIV Env Trimer in Immunized and in Infected Rhesus Macaques Cell Reports 2020 32 DOI:10.1016/j.celrep.2020.108122 PMID:32905766 PMCID:PMC7487785
- Cottrell, C. A., van Schooten, J., Bowman, C. A., Yuan, M., Oyen, D., Shin, M., Morpurgo, R., van der Woude, P., van Breemen, M., Torres, J. L., Patel, R., Gross, J., et al. Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates PLoS Pathogens 2020 16 DOI:10.1371/journal.ppat.1008753 PMID:32866207 PMCID:PMC7485981
- Schorcht, Anna, van den Kerkhof, Tom L. G. M., Cottrell, C., Allen, Joel D., Torres, Jonathan L., Behrens, Anna-Janina, Schermer, Edith E., Burger, Judith A., de Taeye, Steven W., de la Pena, Alba Torrents and Bontjer, Ilja, Gumbs, Stephanie and Ozorowski, Gabriel, LaBranche, Celia C., et al. Neutralizing Antibody Responses Induced by HIV-1 Envelope Glycoprotein SOSIP Trimers Derived from Elite Neutralizers Journal of Virology 2020 94 DOI:10.1128/jvi.01214-20 PMID:32999024 PMCID:PMC7925178
- Guthmiller, J. J., Lan, Ldyl, Fernandez-Quintero, M. L., Han, J., Utset, H. A., Bitar, D. J., Hamel, N. J., Stovicek, O., Li, L., Tepora, M., Henry, C., Neu, K. E., et al. Polyreactive Broadly Neutralizing B cells Are Selected to Provide Defense against Pandemic Threat Influenza Viruses Immunity 2020 53:1230-1244 DOI:10.1016/j.immuni.2020.10.005 PMID:33096040 PMCID:PMC7772752
- Chakraborty, S., Berndsen, Z. T., Hengartner, N. W., Korber, B. T., Ward, A. B., Gnanakaran, S. Quantification of the Resilience and Vulnerability of HIV-1 Native Glycan Shield at Atomistic Detail iScience 2020 23 DOI:10.1016/j.isci.2020.101836 PMID:33319171 PMCID:PMC7724196
- Clausen, T. M., Sandoval, D. R., Spliid, C. B., Pihl, J., Perrett, H. R., Painter, C. D., Narayanan, A., Majowicz, S. A., Kwong, E. M., McVicar, R. N., Thacker, B. E., Glass, C. A., et al. SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2 Cell 2020 183:1043-1057 DOI:10.1016/j.cell.2020.09.033 PMID:32970989 PMCID:PMC7489987
- Bangaru, S., Ozorowski, G., Turner, H. L., Antanasijevic, A., Huang, D. L., Wang, X. N., Torres, J. L., Diedrich, J. K., Tian, J. H., Portnoff, A. D., Patel, N., Massare, M. J., et al. Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate Science 2020 370:1089-1094 DOI:10.1126/science.abe1502 PMID:33082295 PMCID:PMC7857404
- Antanasijevic, A., Ueda, G., Brouwer, P. J. M., Copps, J., Huang, D. L., Allen, J. D., Cottrell, C. A., Yasmeen, A., Sewall, L. M., Bontjer, I., Ketas, T. J., Turner, H. L., et al. Structural and functional evaluation ofde novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens PLoS Pathogens 2020 16 DOI:10.1371/journal.ppat.1008665 PMID:32780770 PMCID:PMC7418955
- Berndsen, Z. T., Chakraborty, S., Wang, X. N., Cottrell, C. A., Torres, J. L., Diedrich, J. K., Lopez, C. A., Yates III, J. R., van Gils, M. J., Paulson, J. C., Gnanakaran, S., Ward, A. B. Visualization of the HIV-1 Env glycan shield across scales Proceedings of the National Academy of Sciences of the United States of America 2020 117:28014-28025 DOI:10.1073/pnas.2000260117 PMID:33093196 PMCID:PMC7668054
- Ringe, R. P., Colin, P., Torres, J. L., Yasmeen, A., Lee, W. H., Cupo, A., Ward, A. B., Klasse, P. J., Moore, J. P. SOS and IP modifications predominantly affect the yield but not other properties of SOSIP.664 HIV-1 Env glycoprotein trimers Journal of Virology 2020 94:e01521-19 DOI:10.1128/jvi.01521-19 PMID:31619555 PMCID:PMC6912111
- Gilchuk, I. M., Bangaru, S., Gilchuk, P., Irving, R. P., Kose, N., Bombardi, R. G., Thornburg, N. J., Creech, C. B., Edwards, K. M., Li, S., Turner, H. L., Yu, W., et al. Influenza H7N9 virus neuraminidase-specific human monoclonal antibodies inhibit viral egress and protect from lethal influenza infection in mice Cell Host & Microbe 2019 26:715-728 DOI:10.1016/j.chom.2019.10.003 PMID:31757769 PMCID:PMC6941661
- Zhu, X., Turner, H. L., Lang, S., McBride, R., Bangaru, S., Gilchuk, I. M., Yu, W., Paulson, J. C., Crowe, J. E., Ward, A. B., Wilson, I. A. Structural basis of protection against H7N9 influenza virus by human anti-N9 neuraminidase antibodies Cell Host & Microbe 2019 26:729-738 DOI:10.1016/j.chom.2019.10.002 PMID:31757767 PMCID:PMC6908751
- Steichen, J. M., Lin, Y. C., Havenar-Daughton, C., Pecetta, S., Ozorowski, G., Willis, J. R., Toy, L., Sok, D., Liguori, A., Kratochvil, S., Torres, J. L., Kalyuzhniy, O., et al. A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses Science 2019 366 DOI:10.1126/science.aax4380 PMID:31672916
- Zhang, L., Irimia, A., He, L., Landais, E., Rantalainen, K., Leaman, D. P., Vollbrecht, T., Stano, A., Sands, D. I., Kim, A. S., Poignard, P., Burton, D. R., et al. An MPER antibody neutralizes HIV-1 using germline features shared among donors Nature Communications 2019 10 DOI:10.1038/s41467-019-12973-1 PMID:31772165 PMCID:PMC6879610
- Quiroz, J. A., Malonis, R. J., Thackray, L. B., Cohen, C. A., Pallesen, J., Jangra, R. K., Brown, R. S., Hofmann, D., Holtsberg, F. W., Shulenin, S., Nyakatura, E. K., Durnell, L. A., et al. Human monoclonal antibodies against chikungunya virus target multiple distinct epitopes in the E1 and E2 glycoproteins PLoS Pathogens 2019 15 DOI:10.1371/journal.ppat.1008061 PMID:31697791 PMCID:PMC6837291
- Wang, N., Rosen, O., Wang, L., Turner, H. L., Stevens, L. J., Corbett, K. S., Bowman, C. A., Pallesen, J., Shi, W., Zhang, Y., Leung, K., Kirchdoerfer, R. N., et al. Structural definition of a neutralization-sensitive epitope on the MERS-CoV S1-NTD Cell Reports 2019 28:3395-3405 DOI:10.1016/j.celrep.2019.08.052 PMID:31553909
- Brouwer, P. J. M., Antanasijevic, A., Berndsen, Z., Yasmeen, A., Fiala, B., Bijl, T. P., Bontjer, I., Bale, J. B., Sheffler, W., Allen, J. D., Schorcht, A., Burgers, J. A., et al. Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle Nature Communications 2019 10 DOI:10.1038/s41467-019-12080-1 PMID:31537780 PMCID:PMC6753213
- Winarski, K. L., Tang, J., Klenow, L., Lee, J., Coyle, E. M., Manischewitz, J., Turner, H. L., Takeda, K., Ward, A. B., Golding, H., Khurana, S. Antibody-dependent enhancement of influenza disease promoted by increase in hemagglutinin stem flexibility and virus fusion kinetics Proceedings of the National Academy of Sciences of the United States of America 2019 116:15194-15199 DOI:10.1073/pnas.1821317116 PMID:31296560 PMCID:PMC6660725
- Whitaker, N., Hickey, J. M., Kaur, K., Xiong, J., Sawant, N., Cupo, A., Lee, W. H., Ozorowski, G., Medina-Ramirez, M., Ward, A. B., Sanders, R. W., Moore, J. P., et al. Developability assessment of physicochemical properties and stability profiles of HIV-1 BG505 SOSIP.664 and BG505 SOSIP.v4.1-GT1.1 gp140 envelope glycoprotein trimers as candidate vaccine antigens Journal of Pharmaceutical Sciences 2019 108:2264-2277 DOI:10.1016/j.xphs.2019.01.033 PMID:30776383 PMCID:PMC6595180
- von Bredow, B., Andrabi, R., Grunst, M., Grandea, A. G., Le, K., Song, G., Berndsen, Z. T., Porter, K., Pallesen, J., Ward, A. B., Burton, D. R., Evans, D. T. Differences in the binding affinity of an HIV-1 V2 apex-specific antibody for the SIVsmm/mac envelope glycoprotein uncouple antibody-dependent cellular cytotoxicity from neutralization Mbio 2019 10:e01255-19 DOI:10.1128/mBio.01255-19 PMID:31266872 PMCID:PMC6606807
- Torrents de la Pena, A., Rantalainen, K., Cottrell, C. A., Allen, J. D., van Gils, M. J., Torres, J. L., Crispin, M., Sanders, R. W., Ward, A. B. Similarities and differences between native HIV-1 envelope glycoprotein trimers and stabilized soluble trimer mimetics PLoS Pathogens 2019 15 DOI:10.1371/journal.ppat.1007920 PMID:31306470 PMCID:PMC6658011
- Yuan, M.*, Cottrell, C. A.*, Ozorowski, G., van Gils, M. J., Kumar, S., Wu, N. C., Sarkar, A., Torres, J. L., de Val, N., Copps, J., Moore, J. P., Sanders, R. W., et al. Conformational plasticity in the HIV-1 fusion peptide facilitates recognition by broadly neutralizing antibodies Cell Host & Microbe 2019 25:873-883 DOI:10.1016/j.chom.2019.04.011 PMID:31194940 (* = equal contribution)
- Saotome, K., Teng, B., Tsui, C. C., Lee, W. H., Tu, Y. H., Kaplan, J. P., Sansom, M. S. P., Liman, E. R., Ward, A. B. Structures of the otopetrin proton channels Otop1 and Otop3 Nature Structural & Molecular Biology 2019 26:518-525 DOI:10.1038/s41594-019-0235-9 PMID:31160780 PMCID:PMC6564688
- Sliepen, K., Han, B. W., Bontjer, I., Mooij, P., Garces, F., Behrens, A. J., Rantalainen, K., Kumar, S., Sarkar, A., Brouwer, P. J. M., Hua, Y., Tolazzi, M., et al. Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence Nature Communications 2019 10 DOI:10.1038/s41467-019-10262-5 PMID:31142746 PMCID:PMC6541627
- Kirchdoerfer, R. N., Ward, A. B. Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors Nature Communications 2019 10 DOI:10.1038/s41467-019-10280-3 PMID:31138817 PMCID:PMC6538669
- Andrabi, R., Pallesen, J., Allen, J. D., Song, G., Zhang, J., de Val, N., Gegg, G., Porter, K., Su, C., Pauthner, M., Newman, A., Bouton-Verville, H., et al. The chimpanzee SIV envelope trimer: structure and deployment as an HIV vaccine template Cell Reports 2019 27:2426-2441 DOI:10.1016/j.celrep.2019.04.082 PMID:31116986 PMCID:PMC6533203
- Bangaru, S., Lang, S., Schotsaert, M., Vanderven, H. A., Zhu, X., Kose, N., Bombardi, R., Finn, J. A., Kent, S. J., Gilchuk, P., Gilchuk, I., Turner, H. L., et al. A site of vulnerability on the influenza virus hemagglutinin head domain trimer interface Cell 2019 177:1136-1152 DOI:10.1016/j.cell.2019.04.011 PMID:31100268
- Cirelli, K. M., Carnathan, D. G., Nogal, B., Martin, J. T., Rodriguez, O. L., Upadhyay, A. A., Enemuo, C. A., Gebru, E. H., Choe, Y., Viviano, F., Nakao, C., Pauthner, M. G., et al. Slow delivery immunization enhances HIV neutralizing antibody and germinal center responses via modulation of immunodominance Cell 2019 177:1153-1171 DOI:10.1016/j.cell.2019.04.012 PMID:31080066
- Murin, C. D., Wilson, I. A., Ward, A. B. Antibody responses to viral infections: a structural perspective across three different enveloped viruses Nature Microbiology 2019 4:734-747 DOI:10.1038/s41564-019-0392-y PMID:30886356
- Kirchdoerfer, R. N., Saphire, E. O., Ward, A. B. Cryo-EM structure of the Ebola virus nucleoprotein-RNA complex Acta Crystallographica Section F-Structural Biology Communications 2019 75:340-347 DOI:10.1107/s2053230x19004424 PMID:31045563 PMCID:PMC6497097
- Lei, L., Yang, Y. H. R., Tran, K., Wang, Y. M., Chiang, C. I., Ozorowski, G., Xiao, Y., Ward, A. B., Wyatt, R. T., Li, Y. The HIV-1 Envelope glycoprotein C3/V4 region defines a prevalent neutralization epitope following immunization Cell Reports 2019 27:586-598 DOI:10.1016/j.celrep.2019.03.039 PMID:30970260 PMCID:PMC6458978
- de Taeye, S. W., Go, E. P., Sliepen, K., de la Pena, A. T., Badal, K., Medina-Ramirez, M., Lee, W. H., Desaire, H., Wilson, I. A., Moore, J. P., Ward, A. B., Sanders, R. W. Stabilization of the V2 loop improves the presentation of V2 loop-associated broadly neutralizing antibody epitopes on HIV-1 envelope trimers Journal of Biological Chemistry 2019 294:5616-5631 DOI:10.1074/jbc.RA118.005396 PMID:30728245 PMCID:PMC6462529
- Meuser, M. E., Rashad, A. A., Ozorowski, G., Dick, A., Ward, A. B., Cocklin, S. Field-based affinity optimization of a novel azabicyclohexane scaffold HIV-1 entry inhibitor Molecules 2019 24 DOI:10.3390/molecules24081581 PMID:31013646 PMCID:PMC6514670
- Ward, A. B. Playing Chess with HIV Immunity 2019 50:283-285 DOI:10.1016/j.immuni.2019.01.011 PMID:30784575
- Kumar, S., Sarkar, A., Pugach, P., Sanders, R. W., Moore, J. P., Ward, A. B., Wilson, I. A. Capturing the inherent structural dynamics of the HIV-1 envelope glycoprotein fusion peptide Nature Communications 2019 10 DOI:10.1038/s41467-019-08738-5 PMID:30770829 PMCID:PMC6377653
- Nemanichvili, N., Tomris, I., Turner, H. L., McBride, R., Grant, O. C., van der Woude, R., Aldosari, M. H., Pieters, R. J., Woods, R. J., Paulson, J. C., Boons, G. J., Ward, A. B., et al. Fluorescent trimeric hemagglutinins reveal multivalent receptor binding properties Journal of Molecular Biology 2019 431:842-856 DOI:10.1016/j.jmb.2018.12.014 PMID:30597163 PMCID:PMC6397626
- Ringe, R. P., Pugach, P., Cottrell, C. A., LaBranche, C. C., Seabright, G. E., Ketas, T. J., Ozorowski, G., Kumar, S., Schorcht, A., van Gils, M. J., Crispin, M., Montefiori, D. C., et al. Closing and opening holes in the glycan shield of HIV-1 envelope glycoprotein SOSIP trimers can redirect the neutralizing antibody response to the newly unmasked epitopes Journal of Virology 2019 93:e01656-18 DOI:10.1128/jvi.01656-18 PMID:30487280 PMCID:PMC6363999
- Turner, H. L., Pallesen, J., Lang, S., Bangaru, S., Urata, S., Li, S., Cottrell, C. A., Bowman, C. A., Crowe, J. E., Wilson, I. A., Ward, A. B. Potent anti-influenza H7 human monoclonal antibody induces separation of hemagglutinin receptor-binding head domains PLoS Biology 2019 17 DOI:10.1371/journal.pbio.3000139 PMID:30716060 PMCID:PMC6375650
- Pauthner, M. G., Nkolola, J. P., Havenar-Daughton, C., Murrell, B., Reiss, S. M., Bastidas, R., Prevost, J., Nedellec, R., von Bredow, B., Abbink, P., Cottrell, C. A., Kulp, D. W., et al. Vaccine-induced protection from homologous tier 2 SHIV challenge in nonhuman primates depends on serum-neutralizing antibody titers Immunity 2019 50:241-252 DOI:10.1016/j.immuni.2018.11.011 PMID:30552025 PMCID:PMC6335502
- Pascal, K. E., Dudgeon, D., Trefry, J. C., Anantpadma, M., Sakurai, Y., Murin, C. D., Turner, H. L., Fairhurst, J., Torres, M., Rafique, A., Yan, Y., Badithe, A., et al. Development of clinical-stage human monoclonal antibodies that treat advanced Ebola virus disease in nonhuman primates Journal of Infectious Diseases 2018 218:S612-S626 DOI:10.1093/infdis/jiy285 PMID:29860496 PMCID:PMC6249601
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- Friesen, R. H. E., Lee, P. S., Stoop, E. J. M., Hoffman, R. M. B., Ekiert, D. C., Bhabha, G., Yu, W., Juraszek, J., Koudstaal, W., Jongeneelen, M., Korse, H. J. W. M., Ophorst, C., et al. A common solution to group 2 influenza virus neutralization Proceedings of the National Academy of Sciences of the United States of America 2014 111:445-450 DOI:10.1073/pnas.1319058110 PMID:24335589 PMCID:PMC3890827
- Tran, K., Poulsen, C., Guenaga, J., de Val, N., Wilson, R., Sundling, C., Li, Y., Stanfield, R. L., Wilson, I. A., Ward, A. B., Hedestam, G. B. K., Wyatt, R. T. Vaccine-elicited primate antibodies use a distinct approach to the HIV-1 primary receptor binding site informing vaccine redesign Proceedings of the National Academy of Sciences of the United States of America 2014 111:E738-E747 DOI:10.1073/pnas.1319512111 PMID:24550318 PMCID:PMC3932900
- Lyumkis, D., Julien, J. P., de Val, N., Cupo, A., Potter, C. S., Klasse, P. J., Burton, D. R., Sanders, R. W., Moore, J. P., Carragher, B., Wilson, I. A., Ward, A. B. Cryo-EM structure of a fully glycosylated soluble cleaved HIV-1 envelope trimer Science 2013 342:1484-1490 DOI:10.1126/science.1245627 PMID:24179160 PMCID:PMC3954647
- Julien, J. P., Cupo, A., Sok, D., Stanfield, R. L., Lyumkis, D., Deller, M. C., Klasse, P. J., Burton, D. R., Sanders, R. W., Moore, J. P., Ward, A. B., Wilson, I. A. Crystal structure of a soluble cleaved HIV-1 envelope trimer Science 2013 342:1477-1483 DOI:10.1126/science.1245625 PMID:24179159 PMCID:PMC3886632
- Wu, Y., West, A. P., Kim, H. J., Thornton, M. E., Ward, A. B., Bjorkman, P. J. Structural basis for enhanced HIV-1 neutralization by a dimeric immunoglobulin G form of the glycan-recognizing antibody 2G12 Cell Reports 2013 5:1443-1455 DOI:10.1016/j.celrep.2013.11.015 PMID:24316082 PMCID:PMC3919625
- Kong, L., Giang, E., Nieusma, T., Kadam, R. U., Cogburn, K. E., Hua, Y., Dai, X., Stanfield, R. L., Burton, D. R., Ward, A. B., Wilson, I. A., Law, M. Hepatitis C virus E2 envelope glycoprotein core structure Science 2013 342:1090-1094 DOI:10.1126/science.1243876 PMID:24288331 PMCID:PMC3954638
- Ringe, R. P., Sanders, R. W., Yasmeen, A., Kim, H. J., Lee, J. H., Cupo, A., Korzun, J., Derking, R., van Montfort, T., Julien, J. P., Wilson, I. A., Klasse, P. J., et al. Cleavage strongly influences whether soluble HIV-1 envelope glycoprotein trimers adopt a native-like conformation Proceedings of the National Academy of Sciences of the United States of America 2013 110:18256-18261 DOI:10.1073/pnas.1314351110 PMID:24145402 PMCID:PMC3831437
- Hong, M., Lee, P. S., Hoffman, R. M. B., Zhu, X., Krause, J. C., Laursen, N. S., Yoon, S. I., Song, L., Tussey, L., Crowe, J. E., Ward, A. B., Wilson, I. A. Antibody recognition of the pandemic H1N1 Influenza virus hemagglutinin receptor binding site Journal of Virology 2013 87:12471-12480 DOI:10.1128/jvi.01388-13 PMID:24027321 PMCID:PMC3807900
- Julien, J. P., Sok, D., Khayat, R., Lee, J. H., Doores, K. J., Walker, L. M., Ramos, A., Diwanji, D. C., Pejchal, R., Cupo, A., Katpally, U., Depetris, R. S., et al. Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans PLoS Pathogens 2013 9:e1003342 DOI:10.1371/journal.ppat.1003342 PMID:23658524 PMCID:PMC3642082
- Klasse, P. J., Depetris, R. S., Pejchal, R., Julien, J. P., Khayat, R., Lee, J. H., Marozsan, A. J., Cupo, A., Cocco, N., Korzun, J., Yasmeen, A., Ward, A. B., et al. Influences on Trimerization and Aggregation of Soluble, Cleaved HIV-1 SOSIP Envelope Glycoprotein Journal of Virology 2013 87:9873-9885 DOI:10.1128/jvi.01226-13 PMID:23824824 PMCID:PMC3754145
- Khayat, R., Lee, J. H., Julien, J. P., Cupo, A., Klasse, P. J., Sanders, R. W., Moore, J. P., Wilson, I. A., Ward, A. B. Structural characterization of cleaved, soluble HIV-1 envelope glycoprotein trimers Journal of Virology 2013 87:9865-9872 DOI:10.1128/jvi.01222-13 PMID:23824817 PMCID:PMC3754114
- Ward, A. B., Szewczyk, P., Grimard, V., Lee, C. W., Martinez, L., Doshi, R., Caya, A., Villaluz, M., Pardon, E., Cregger, C., Swartz, D. J., Falson, P. G., et al. Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain Proceedings of the National Academy of Sciences of the United States of America 2013 110:13386-13391 DOI:10.1073/pnas.1309275110 PMID:23901103 PMCID:PMC3746859
- Kong, L., Lee, J. H., Doores, K. J., Murin, C. D., Julien, J. P., McBride, R., Liu, Y., Marozsan, A., Cupo, A., Klasse, P. J., Hoffenberg, S., Caulfield, M., et al. Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120 Nature Structural & Molecular Biology 2013 20:796-803 DOI:10.1038/nsmb.2594 PMID:23708606 PMCID:PMC3823233
- Jardine, J., Julien, J. P., Menis, S., Ota, T., Kalyuzhniy, O., McGuire, A., Sok, D., Huang, P. S., MacPherson, S., Jones, M., Nieusma, T., Mathison, J., et al. Rational HIV immunogen design to target specific germline B cell receptors Science 2013 340:711-716 DOI:10.1126/science.1234150 PMID:23539181 PMCID:PMC3689846
- Lee, S. C., Bennett, B. C., Hong, W. X., Fu, Y., Baker, K. A., Marcoux, J., Robinson, C. V., Ward, A. B., Halpert, J. R., Stevens, R. C., Stout, C. D., Yeager, M. J., et al. Steroid-based facial amphiphiles for stabilization and crystallization of membrane proteins Proceedings of the National Academy of Sciences of the United States of America 2013 110:E1203-11 DOI:10.1073/pnas.1221442110 PMID:23479627 PMCID:PMC3612649
- Julien, J. P., Lee, J. H., Cupo, A., Murin, C. D., Derking, R., Hoffenberg, S., Caulfield, M. J., King, C. R., Marozsan, A. J., Klasse, P. J., Sanders, R. W., Moore, J. P., et al. Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9 Proceedings of the National Academy of Sciences of the United States of America 2013 110:213-218 DOI:10.1073/pnas.1217537110 PMID:23426631 PMCID:PMC3600498
- Sanders, R. W., Derking, R., Cupo, A., Julien, J. P., Yasmeen, A., de Val, N., Kim, H. J., Blattner, C., de la Pena, A. T., Korzun, J., Golabek, M., de los Reyes, K., et al. A next-generation cleaved, soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies PLoS Pathogens 2013 9:e1003618 DOI:10.1371/journal.ppat.1003618 PMID:24068931 PMCID:PMC3777863
- Ward, A. B., Sali, A., Wilson, I. A. Biochemistry. Integrative structural biology Science 2013 339:913-915 DOI:10.1126/science.1228565 PMID:23430643 PMCID:PMC3633482
- Thornburg, N. J., Nannemann, D. P., Blum, D. L., Belser, J. A., Tumpey, T. M., Deshpande, S., Fritz, G. A., Sapparapu, G., Krause, J. C., Lee, J. H., Ward, A. B., Lee, D. E., et al. Human antibodies that neutralize respiratory droplet transmissible H5N1 influenza viruses Journal of Clinical Investigation 2013 123:4405-4409 DOI:10.1172/jci69377 PMID:23999429 PMCID:PMC3784541
- Burton, D. R., Ahmed, R., Barouch, D. H., Butera, S. T., Crotty, S., Godzik, A., Kaufmann, D. E., McElrath, M. J., Nussenzweig, M. C., Pulendran, B., Scanlan, C. N., Schief, W. R., et al. A blueprint for HIV vaccine discovery Cell Host & Microbe 2012 12:396-407 DOI:10.1016/j.chom.2012.09.008 PMID:23084910 PMCID:PMC3513329
- Ekiert, D. C., Kashyap, A. K., Steel, J., Rubrum, A., Bhabha, G., Khayat, R., Lee, J. H., Dillon, M. A., O'Neil, R. E., Faynboym, A. M., Horowitz, M., Horowitz, L., et al. Cross-neutralization of influenza a viruses mediated by a single antibody loop Nature 2012 489:526-32 DOI:10.1038/nature11414 PMID:22982990 PMCID:PMC3538848
- Dreyfus, C., Laursen, N. S., Kwaks, T., Zuijdgeest, D., Khayat, R., Ekiert, D. C., Lee, J. H., Metlagel, Z., Bujny, M. V., Jongeneelen, M., van der Vlugt, R., Lamrani, M., et al. Highly conserved protective epitopes on influenza B viruses Science 2012 337:1343-1348 DOI:10.1126/science.1222908 PMID:22878502 PMCID:PMC3538841
- Ward, A. B., Guvench, O., Hills, R. D. Coarse grain lipid-protein molecular interactions and diffusion with MsbA flippase Proteins-Structure Function and Bioinformatics 2012 80:2178-2190 DOI:10.1002/prot.24108 PMID:22552999
- Depetris, R. S., Julien, J. P., Khayat, R., Lee, J. H., Pejchal, R., Katpally, U., Cocco, N., Kachare, M., Massi, E., David, K. B., Cupo, A., Marozsan, A. J., et al. Partial enzymatic deglycosylation preserves the structure of cleaved recombinant HIV-1 envelope glycoprotein trimers Journal of Biological Chemistry 2012 287:24239-24254 DOI:10.1074/jbc.M112.371898 PMID:22645128 PMCID:PMC3397850
- McLellan, J. S., Pancera, M., Carrico, C., Gorman, J., Julien, J. P., Khayat, R., Louder, R., Pejchal, R., Sastry, M., Dai, K. F., O'Dell, S., Patel, N., et al. Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9 Nature 2011 480:336-343 DOI:10.1038/nature10696 PMID:22113616 PMCID:PMC3406929
- Fisher, L. S., Ward, A., Milligan, R. A., Unwin, N., Potter, C. S., Carragher, B. A helical processing pipeline for EM structure determination of membrane proteins Methods 2011 55:350-362 DOI:10.1016/j.ymeth.2011.09.013 PMID:21964395 PMCID:PMC3262078
- Pejchal, R., Doores, K. J., Walker, L. M., Khayat, R., Huang, P. S., Wang, S. K., Stanfield, R. L., Julien, J. P., Ramos, A., Crispin, M., Depetris, R., Katpally, U., et al. A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield Science 2011 334:1097-1103 DOI:10.1126/science.1213256 PMID:21998254 PMCID:PMC3280215
- Bai, J. P., Swartz, D. J., Protasevich, II, Brouillette, C. G., Harrell, P. M., Hildebrandt, E., Gasser, B., Mattanovich, D., Ward, A., Chang, G., Urbatsch, I. L. A gene optimization strategy that enhances production of fully functional p-glycoprotein in pichia pastoris PLoS One 2011 6:e22577 DOI:10.1371/journal.pone.0022577 PMID:21826197 PMCID:PMC3149604
- Perz-Edwards, R. J., Irving, T. C., Baumann, B. A. J., Gore, D., Hutchinson, D. C., Krzic, U., Porter, R. L., Ward, A. B., Reedy, M. K. X-ray diffraction evidence for myosin-troponin connections and tropomyosin movement during stretch activation of insect flight muscle Proceedings of the National Academy of Sciences of the United States of America 2011 108:120-125 DOI:10.1073/pnas.1014599107 PMID:21148419 PMCID:PMC3017141
- Glaves, J. P., Fisher, L., Ward, A., Young, H. S. Helical crystallization of two example membrane proteins MsbA and the Ca(2+)-ATPase Methods in Enzymology 2010 483:143-159 DOI:10.1016/s0076-6879(10)83007-1 PMID:20888473
- Gutmann, D. A. P., Ward, A., Urbatsch, I. L., Chang, G., van Veen, H. W. Understanding polyspecificity of multidrug ABC transporters: closing in on the gaps in ABCB1 Trends in Biochemical Sciences 2010 35:36-42 DOI:10.1016/j.tibs.2009.07.009 PMID:19819701 PMCID:PMC4608440
- Aller, S. G., Yu, J., Ward, A., Weng, Y., Chittaboina, S., Zhuo, R. P., Harrell, P. M., Trinh, Y. T., Zhang, Q. H., Urbatsch, I. L., Chang, G. Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding Science 2009 323:1718-1722 DOI:10.1126/science.1168750 PMID:19325113 PMCID:PMC2720052
- Ward, A., Mulligan, S., Carragher, B., Chang, G., Milligan, R. A. Nucleotide dependent packing differences in helical crystals of the ABC transporter MsbA Journal of Structural Biology 2009 165:169-175 DOI:10.1016/j.jsb.2008.11.006 PMID:19114108 PMCID:PMC2703300
- Littlefield, K. P., Ward, A. B., Chappie, J. S., Reedy, M. K., Bernstein, S. I., Milligan, R. A., Reedy, M. C. Similarities and differences between frozen-hydrated, rigor acto-S1 complexes of insect flight and chicken skeletal muscles Journal of Molecular Biology 2008 381:519-528 DOI:10.1016/j.jmb.2008.06.029 PMID:18588896 PMCID:PMC2567842
- Bekyarova, T. I., Reedy, M. C., Baumann, B. A. J., Tregear, R. T., Ward, A., Krzic, U., Prince, K. M., Perz-Edwards, R. J., Reconditi, M., Gore, D., Irving, T. C., Reedy, M. K. Reverse actin sliding triggers strong myosin binding that moves tropomyosin Proceedings of the National Academy of Sciences of the United States of America 2008 105:10372-10377 DOI:10.1073/pnas.0709877105 PMID:18658238 PMCID:PMC2492518
- Ward, A., Reyes, C. L., Yu, J., Roth, C. B., Chang, G. Flexibility in the ABC transporter MsbA: Alternating access with a twist Proceedings of the National Academy of Sciences of the United States of America 2007 104:19005-19010 DOI:10.1073/pnas.0709388104 PMID:18024585 PMCID:PMC2141898
- Zhang, Q. H., Ma, X. Q., Ward, A., Hong, W. X., Jaakola, V. P., Stevens, R. C., Finn, M. G., Chang, G. Designing facial amphiphiles for the stabilization of integral membrane proteins Angewandte Chemie-International Edition 2007 46:7023-7025 DOI:10.1002/anie.200701556 PMID:17691085
- Reyes, C. L., Ward, A., Yu, J., Chang, G. The structures of MsbA: Insight into ABC transporter-mediated multidrug efflux FEBS Letters 2006 580:1042-1048 DOI:10.1016/j.febslet.2005.11.033 PMID:16337944
- Ward, A., Moody, M. F., Sheehan, B., Milligan, R. A., Carragher, B. Windex: A toolset for indexing helices Journal of Structural Biology 2003 144:172-183 DOI:10.1016/j.jsb.2003.10.008 PMID:14643220

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