Ward, Andrew

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- Gilchuk, P., Murin, C. D., Milligan, J. C., Cross, R. W., Mire, C. E., Ilinykh, P. A., Huang, K., Kuzmina, N., Altman, P. X., Hui, S., Gunn, B. M., Bryan, A. L., et al. Analysis of a therapeutic antibody cocktail reveals determinants for cooperative and broad ebolavirus neutralization Immunity 2020 52:388-403 DOI:10.1016/j.immuni.2020.01.001 PMID:32023489
- Moyer, T. J., Kato, Y., Abraham, W., Chang, J. Y. H., Kulp, D. W., Watson, N., Turner, H. L., Menis, S., Abbott, R. K., Bhiman, J. N., Melo, M. B., Simon, H. A., et al. Engineered immunogen binding to alum adjuvant enhances humoral immunity Nature Medicine 2020 26:430-440 DOI:10.1038/s41591-020-0753-3 PMID:32066977
- Ringe, R. P., Portillo, V. M. C., Dosenovic, P., Ketas, T. J., Ozorowski, G., Nogal, B., Perez, L., LaBranche, C. C., Lim, J., Francomano, E., Wilson, I. A., Sanders, R. W., et al. Neutralizing antibody induction by HIV-1 envelope glycoprotein SOSIP trimers on iron oxide nanoparticles may be impaired by mannose binding lectin Journal of Virology 2020 94 DOI:10.1128/jvi.01883-19 PMID:31852794
- Ringe, R. P., Colin, P., Torres, J. L., Yasmeen, A., Lee, W. H., Cupo, A., Ward, A. B., Klasse, P. J., Moore, J. P. SOS and IP modifications predominantly affect the yield but not other properties of SOSIP.664 HIV-1 Env glycoprotein trimers Journal of Virology 2020 94:e01521-19 DOI:10.1128/jvi.01521-19 PMID:31619555 PMCID:PMC6912111
- Steichen, J. M., Lin, Y. C., Havenar-Daughton, C., Pecetta, S., Ozorowski, G., Willis, J. R., Toy, L., Sok, D., Liguori, A., Kratochvil, S., Torres, J. L., Kalyuzhniy, O., et al. A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses Science 2019 366 DOI:10.1126/science.aax4380 PMID:31672916
- Bangaru, S., Lang, S., Schotsaert, M., Vanderven, H. A., Zhu, X., Kose, N., Bombardi, R., Finn, J. A., Kent, S. J., Gilchuk, P., Gilchuk, I., Turner, H. L., et al. A site of vulnerability on the influenza virus hemagglutinin head domain trimer interface Cell 2019 177:1136-1152 DOI:10.1016/j.cell.2019.04.011 PMID:31100268
- Zhang, L., Irimia, A., He, L., Landais, E., Rantalainen, K., Leaman, D. P., Vollbrecht, T., Stano, A., Sands, D. I., Kim, A. S., Poignard, P., Burton, D. R., et al. An MPER antibody neutralizes HIV-1 using germline features shared among donors Nature Communications 2019 10 DOI:10.1038/s41467-019-12973-1 PMID:31772165 PMCID:PMC6879610
- Murin, C. D., Wilson, I. A., Ward, A. B. Antibody responses to viral infections: a structural perspective across three different enveloped viruses Nature Microbiology 2019 4:734-747 DOI:10.1038/s41564-019-0392-y PMID:30886356
- Winarski, K. L., Tang, J., Klenow, L., Lee, J., Coyle, E. M., Manischewitz, J., Turner, H. L., Takeda, K., Ward, A. B., Golding, H., Khurana, S. Antibody-dependent enhancement of influenza disease promoted by increase in hemagglutinin stem flexibility and virus fusion kinetics Proceedings of the National Academy of Sciences of the United States of America 2019 116:15194-15199 DOI:10.1073/pnas.1821317116 PMID:31296560 PMCID:PMC6660725
- Kumar, S., Sarkar, A., Pugach, P., Sanders, R. W., Moore, J. P., Ward, A. B., Wilson, I. A. Capturing the inherent structural dynamics of the HIV-1 envelope glycoprotein fusion peptide Nature Communications 2019 10 DOI:10.1038/s41467-019-08738-5 PMID:30770829 PMCID:PMC6377653
- Ringe, R. P., Pugach, P., Cottrell, C. A., LaBranche, C. C., Seabright, G. E., Ketas, T. J., Ozorowski, G., Kumar, S., Schorcht, A., van Gils, M. J., Crispin, M., Montefiori, D. C., et al. Closing and opening holes in the glycan shield of HIV-1 envelope glycoprotein SOSIP trimers can redirect the neutralizing antibody response to the newly unmasked epitopes Journal of Virology 2019 93:e01656-18 DOI:10.1128/jvi.01656-18 PMID:30487280 PMCID:PMC6363999
- Yuan, M.*, Cottrell, C. A.*, Ozorowski, G., van Gils, M. J., Kumar, S., Wu, N. C., Sarkar, A., Torres, J. L., de Val, N., Copps, J., Moore, J. P., Sanders, R. W., et al. Conformational plasticity in the HIV-1 fusion peptide facilitates recognition by broadly neutralizing antibodies Cell Host & Microbe 2019 25:873-883 DOI:10.1016/j.chom.2019.04.011 PMID:31194940 (* = equal contribution)
- Kirchdoerfer, R. N., Saphire, E. O., Ward, A. B. Cryo-EM structure of the Ebola virus nucleoprotein-RNA complex Acta Crystallographica Section F-Structural Biology Communications 2019 75:340-347 DOI:10.1107/s2053230x19004424 PMID:31045563 PMCID:PMC6497097
- Whitaker, N., Hickey, J. M., Kaur, K., Xiong, J., Sawant, N., Cupo, A., Lee, W. H., Ozorowski, G., Medina-Ramirez, M., Ward, A. B., Sanders, R. W., Moore, J. P., et al. Developability assessment of physicochemical properties and stability profiles of HIV-1 BG505 SOSIP.664 and BG505 SOSIP.v4.1-GT1.1 gp140 envelope glycoprotein trimers as candidate vaccine antigens Journal of Pharmaceutical Sciences 2019 108:2264-2277 DOI:10.1016/j.xphs.2019.01.033 PMID:30776383 PMCID:PMC6595180
- von Bredow, B., Andrabi, R., Grunst, M., Grandea, A. G., Le, K., Song, G., Berndsen, Z. T., Porter, K., Pallesen, J., Ward, A. B., Burton, D. R., Evans, D. T. Differences in the binding affinity of an HIV-1 V2 apex-specific antibody for the SIVsmm/mac envelope glycoprotein uncouple antibody-dependent cellular cytotoxicity from neutralization Mbio 2019 10:e01255-19 DOI:10.1128/mBio.01255-19 PMID:31266872 PMCID:PMC6606807
- Brouwer, P. J. M., Antanasijevic, A., Berndsen, Z., Yasmeen, A., Fiala, B., Bijl, T. P., Bontjer, I., Bale, J. B., Sheffler, W., Allen, J. D., Schorcht, A., Burgers, J. A., et al. Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle Nature Communications 2019 10 DOI:10.1038/s41467-019-12080-1 PMID:31537780 PMCID:PMC6753213
- Meuser, M. E., Rashad, A. A., Ozorowski, G., Dick, A., Ward, A. B., Cocklin, S. Field-based affinity optimization of a novel azabicyclohexane scaffold HIV-1 entry inhibitor Molecules 2019 24 DOI:10.3390/molecules24081581 PMID:31013646 PMCID:PMC6514670
- Nemanichvili, N., Tomris, I., Turner, H. L., McBride, R., Grant, O. C., van der Woude, R., Aldosari, M. H., Pieters, R. J., Woods, R. J., Paulson, J. C., Boons, G. J., Ward, A. B., et al. Fluorescent trimeric hemagglutinins reveal multivalent receptor binding properties Journal of Molecular Biology 2019 431:842-856 DOI:10.1016/j.jmb.2018.12.014 PMID:30597163 PMCID:PMC6397626
- Quiroz, J. A., Malonis, R. J., Thackray, L. B., Cohen, C. A., Pallesen, J., Jangra, R. K., Brown, R. S., Hofmann, D., Holtsberg, F. W., Shulenin, S., Nyakatura, E. K., Durnell, L. A., et al. Human monoclonal antibodies against chikungunya virus target multiple distinct epitopes in the E1 and E2 glycoproteins PLoS Pathogens 2019 15 DOI:10.1371/journal.ppat.1008061 PMID:31697791 PMCID:PMC6837291
- Gilchuk, I. M., Bangaru, S., Gilchuk, P., Irving, R. P., Kose, N., Bombardi, R. G., Thornburg, N. J., Creech, C. B., Edwards, K. M., Li, S., Turner, H. L., Yu, W., et al. Influenza H7N9 virus neuraminidase-specific human monoclonal antibodies inhibit viral egress and protect from lethal influenza infection in mice Cell Host & Microbe 2019 26:715-728 DOI:10.1016/j.chom.2019.10.003 PMID:31757769 PMCID:PMC6941661
- Ward, A. B. Playing Chess with HIV Immunity 2019 50:283-285 DOI:10.1016/j.immuni.2019.01.011 PMID:30784575
- Turner, H. L., Pallesen, J., Lang, S., Bangaru, S., Urata, S., Li, S., Cottrell, C. A., Bowman, C. A., Crowe, J. E., Wilson, I. A., Ward, A. B. Potent anti-influenza H7 human monoclonal antibody induces separation of hemagglutinin receptor-binding head domains PLoS Biology 2019 17 DOI:10.1371/journal.pbio.3000139 PMID:30716060 PMCID:PMC6375650
- Torrents de la Pena, A., Rantalainen, K., Cottrell, C. A., Allen, J. D., van Gils, M. J., Torres, J. L., Crispin, M., Sanders, R. W., Ward, A. B. Similarities and differences between native HIV-1 envelope glycoprotein trimers and stabilized soluble trimer mimetics PLoS Pathogens 2019 15 DOI:10.1371/journal.ppat.1007920 PMID:31306470 PMCID:PMC6658011
- Cirelli, K. M., Carnathan, D. G., Nogal, B., Martin, J. T., Rodriguez, O. L., Upadhyay, A. A., Enemuo, C. A., Gebru, E. H., Choe, Y., Viviano, F., Nakao, C., Pauthner, M. G., et al. Slow delivery immunization enhances HIV neutralizing antibody and germinal center responses via modulation of immunodominance Cell 2019 177:1153-1171 DOI:10.1016/j.cell.2019.04.012 PMID:31080066
- de Taeye, S. W., Go, E. P., Sliepen, K., de la Pena, A. T., Badal, K., Medina-Ramirez, M., Lee, W. H., Desaire, H., Wilson, I. A., Moore, J. P., Ward, A. B., Sanders, R. W. Stabilization of the V2 loop improves the presentation of V2 loop-associated broadly neutralizing antibody epitopes on HIV-1 envelope trimers Journal of Biological Chemistry 2019 294:5616-5631 DOI:10.1074/jbc.RA118.005396 PMID:30728245 PMCID:PMC6462529
- Zhu, X., Turner, H. L., Lang, S., McBride, R., Bangaru, S., Gilchuk, I. M., Yu, W., Paulson, J. C., Crowe, J. E., Ward, A. B., Wilson, I. A. Structural basis of protection against H7N9 influenza virus by human anti-N9 neuraminidase antibodies Cell Host & Microbe 2019 26:729-738 DOI:10.1016/j.chom.2019.10.002 PMID:31757767 PMCID:PMC6908751
- Wang, N., Rosen, O., Wang, L., Turner, H. L., Stevens, L. J., Corbett, K. S., Bowman, C. A., Pallesen, J., Shi, W., Zhang, Y., Leung, K., Kirchdoerfer, R. N., et al. Structural definition of a neutralization-sensitive epitope on the MERS-CoV S1-NTD Cell Reports 2019 28:3395-3405 DOI:10.1016/j.celrep.2019.08.052 PMID:31553909
- Sliepen, K., Han, B. W., Bontjer, I., Mooij, P., Garces, F., Behrens, A. J., Rantalainen, K., Kumar, S., Sarkar, A., Brouwer, P. J. M., Hua, Y., Tolazzi, M., et al. Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence Nature Communications 2019 10 DOI:10.1038/s41467-019-10262-5 PMID:31142746 PMCID:PMC6541627
- Kirchdoerfer, R. N., Ward, A. B. Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors Nature Communications 2019 10 DOI:10.1038/s41467-019-10280-3 PMID:31138817 PMCID:PMC6538669
- Saotome, K., Teng, B., Tsui, C. C., Lee, W. H., Tu, Y. H., Kaplan, J. P., Sansom, M. S. P., Liman, E. R., Ward, A. B. Structures of the otopetrin proton channels Otop1 and Otop3 Nature Structural & Molecular Biology 2019 26:518-525 DOI:10.1038/s41594-019-0235-9 PMID:31160780 PMCID:PMC6564688
- Lei, L., Yang, Y. H. R., Tran, K., Wang, Y. M., Chiang, C. I., Ozorowski, G., Xiao, Y., Ward, A. B., Wyatt, R. T., Li, Y. The HIV-1 Envelope glycoprotein C3/V4 region defines a prevalent neutralization epitope following immunization Cell Reports 2019 27:586-598 DOI:10.1016/j.celrep.2019.03.039 PMID:30970260 PMCID:PMC6458978
- Andrabi, R., Pallesen, J., Allen, J. D., Song, G., Zhang, J., de Val, N., Gegg, G., Porter, K., Su, C., Pauthner, M., Newman, A., Bouton-Verville, H., et al. The chimpanzee SIV envelope trimer: structure and deployment as an HIV vaccine template Cell Reports 2019 27:2426-2441 DOI:10.1016/j.celrep.2019.04.082 PMID:31116986 PMCID:PMC6533203
- Pauthner, M. G., Nkolola, J. P., Havenar-Daughton, C., Murrell, B., Reiss, S. M., Bastidas, R., Prevost, J., Nedellec, R., von Bredow, B., Abbink, P., Cottrell, C. A., Kulp, D. W., et al. Vaccine-induced protection from homologous tier 2 SHIV challenge in nonhuman primates depends on serum-neutralizing antibody titers Immunity 2019 50:241-252 DOI:10.1016/j.immuni.2018.11.011 PMID:30552025 PMCID:PMC6335502
- Bangaru, S., Zhang, H., Gilchuk, I. M., Voss, T. G., Irving, R. P., Gilchuk, P., Matta, P., Zhu, X., Lang, S., Nieusma, T., Richt, J. A., Albrecht, R. A., et al. A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA Nature Communications 2018 9 DOI:10.1038/s41467-018-04704-9 PMID:29991715 PMCID:PMC6039445
- Flyak, A. I., Kuzmina, N., Murin, C. D., Bryan, C., Davidson, E., Gilchuk, P., Gulka, C. P., Ilinykh, P. A., Shen, X. L., Huang, K., Ramanathan, P., Turner, H., et al. Broadly neutralizing antibodies from human survivors target a conserved site in the Ebola virus glycoprotein HR2-MPER region Nature Microbiology 2018 3:670-677 DOI:10.1038/s41564-018-0157-z PMID:29736037
- Bale, S., Martine, A., Wilson, R., Behrens, A. J., Le Fourn, V., de Val, N., Sharma, S. K., Tran, K., Torres, J. L., Girod, P. A., Ward, A. B., Crispin, M., et al. Cleavage -Independent HIV-1 Trimers From CHO Cell Lines Elicit Robust Autologous Tier 2 Neutralizing Antibodies Frontiers in Immunology 2018 9 DOI:10.3389/fimmu.2018.01116 PMID:29881382 PMCID:PMC5976746
- Rantalainen, K., Berndsen, Z. T., Murrell, S., Cao, L., Omorodion, O., Torres, J. L., Wu, M., Umotoy, J., Copps, J., Poignard, P., Landais, E., Paulson, J. C., et al. Co-evolution of HIV envelope and apex-targeting neutralizing antibody lineage provides benchmarks for vaccine design Cell Reports 2018 23:3249-3261 DOI:10.1016/j.celrep.2018.05.046 PMID:29898396 PMCID:PMC6019700
- Oyen, D., Torres, J. L., Cottrell, C. A., King, C. R., Wilson, I. A., Ward, A. B. Cryo-EM structure of P. falciparum circumsporozoite protein with a vaccine-elicited antibody is stabilized by somatically mutated inter-Fab contacts Science Advances 2018 4 DOI:10.1126/sciadv.aau8529 PMID:30324137 PMCID:PMC6179375
- Jojoa-Cruz, S., Saotome, K., Murthy, S. E., Tsui, C. C. A., Sansom, M. S. P., Patapoutian, A., Ward, A. B. Cryo-EM structure of the mechanically activated ion channel OSCA1.2 Elife 2018 7 DOI:10.7554/eLife.41845 PMID:30382939 PMCID:PMC6235563
- Wu, N. C., Ward, A. B. Deception through mimicry: a cellular antiviral strategy Cell 2018 175:1728-1729 DOI:10.1016/j.cell.2018.11.033 PMID:30550784
- Pascal, K. E., Dudgeon, D., Trefry, J. C., Anantpadma, M., Sakurai, Y., Murin, C. D., Turner, H. L., Fairhurst, J., Torres, M., Rafique, A., Yan, Y., Badithe, A., et al. Development of clinical-stage human monoclonal antibodies that treat advanced Ebola virus disease in nonhuman primates Journal of Infectious Diseases 2018 218:S612-S626 DOI:10.1093/infdis/jiy285 PMID:29860496 PMCID:PMC6249601
- Cao, L. W., Pauthner, M., Andrabi, R., Rantalainen, K., Berndsen, Z., Diedrich, J. K., Menis, S., Sok, D., Bastidas, R., Park, S. K. R., Delahunty, C. M., He, L., et al. Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer Nature Communications 2018 9 DOI:10.1038/s41467-018-06121-4 PMID:30209313 PMCID:PMC6135743
- Ozorowski, G., Cupo, A., Golabek, M., LoPiccolo, M., Ketas, T. A., Cavallary, M., Cottrell, C. A., Klasse, P. J., Ward, A. B., Moore, J. P. Effects of adjuvants on HIV-1 envelope glycoprotein SOSIP trimers in vitro Journal of Virology 2018 92 DOI:10.1128/jvi.00381-18 PMID:29669838 PMCID:PMC6002727
- Bianchi, M., Turner, H. L., Nogal, B., Cottrell, C. A., Oyen, D., Pauthner, M., Bastidas, R., Nedellec, R., McCoy, L. E., Wilson, I. A., Burton, D. R., Ward, A. B., et al. Electron-microscopy-based epitope mapping defines specificities of polyclonal antibodies elicited during HIV-1 BG505 envelope trimer immunization Immunity 2018 49:288-300 DOI:10.1016/j.immuni.2018.07.009 PMID:30097292 PMCID:PMC6104742
- Shrivastava, T., Samal, S., Tyagi, A. K., Goswami, S., Kumar, N., Ozorowski, G., Ward, A. B., Chakrabarti, B. K. Envelope proteins of two HIV-1 clades induced different epitope-specific antibody response Vaccine 2018 36:1627-1636 DOI:10.1016/j.vaccine.2018.01.081 PMID:29429810
- Klasse, P. J., Ketas, T. J., Cottrell, C. A., Ozorowski, G., Debnath, G., Camara, D., Francomano, E., Pugach, P., Ringe, R. P., LaBranche, C. C., van Gils, M. J., Bricault, C. A., et al. Epitopes for neutralizing antibodies induced by HIV-1 envelope glycoprotein BG505 SOSIP trimers in rabbits and macaques PLoS Pathogens 2018 14 DOI:10.1371/journal.ppat.1006913 PMID:29474444 PMCID:PMC5841823
- Maurer, M. A., Meyer, L., Bianchi, M., Turner, H. L., Le, N. P. L., Steck, M., Wyrzucki, A., Orlowski, V., Ward, A. B., Crispin, M., Hangartner, L. Glycosylation of human IgA directly inhibits influenza A and other sialic-acid-binding viruses Cell Reports 2018 23:90-99 DOI:10.1016/j.celrep.2018.03.027 PMID:29617676
- He, L., Kumar, S., Allen, J. D., Huang, D. L., Lin, X., Mann, C. J., Saye-Francisco, K. L., Copps, J., Sarkar, A., Blizard, G. S., Ozorowski, G., Sok, D., et al. HIV-1 vaccine design through minimizing envelope metastability Science Advances 2018 4 DOI:10.1126/sciadv.aau6769 PMID:30474059 PMCID:PMC6248932
- Behrens, A. J., Kumar, A., Medina-Ramirez, M., Cupo, A., Marshall, K., Portillo, V. M. C., Harvey, D. J., Ozorowski, G., Zitzmann, N., Wilson, I. A., Ward, A. B., Struwe, W. B., et al. Integrity of glycosylation processing of a glycan-depleted trimeric HIV-1 immunogen targeting key B-cell lineages Journal of Proteome Research 2018 17:987-999 DOI:10.1021/acs.jproteome.7b00639 PMID:29420040 PMCID:PMC5846105
- Gilchuk, P., Kuzmina, N., Ilinykh, P. A., Huang, K., Gunn, B. M., Bryan, A., Davidson, E., Doranz, B. J., Turner, H. L., Fusco, M. L., Bramble, M. S., Hoff, N. A., et al. Multifunctional pan-ebolavirus antibody recognizes a site of broad vulnerability on the ebolavirus glycoprotein Immunity 2018 49:363-374 DOI:10.1016/j.immuni.2018.06.018 PMID:30029854 PMCID:PMC6104738
- Murthy, S. E., Dubin, A. E., Whitwam, T., Jojoa-Cruz, S., Cahalan, S. M., Mousavi, S. A. R., Ward, A. B., Patapoutian, A. OSCA/TMEM63 are an evolutionarily conserved family of mechanically activated ion channels Elife 2018 7 DOI:10.7554/eLife.41844 PMID:30382938 PMCID:PMC6235560
- Aldon, Y., McKay, P. F., Allen, J., Ozorowski, G., Levai, R. F., Tolazzi, M., Rogers, P., He, L., de Val, N., Fabian, K., Scarlatti, G., Zhu, J., et al. Rational design of DNA-expressed stabilized native-like HIV-1 envelope trimers Cell Reports 2018 24:3324-3338 DOI:10.1016/j.celrep.2018.08.051 PMID:30232012 PMCID:PMC6167709
- Steinhardt, J. J., Guenaga, J., Turner, H. L., McKee, K., Louder, M. K., O'Dell, S., Chiang, C. I., Lei, L., Galkin, A., Andrianov, A. K., Doria-Rose, N. A., Bailer, R. T., et al. Rational design of a trispecific antibody targeting the HIV-1 Env with elevated anti-viral activity Nature Communications 2018 9 DOI:10.1038/s41467-018-03335-4 PMID:29491415 PMCID:PMC5830440
- de Taeye, S. W., de la Pena, A. T., Vecchione, A., Scutigliani, E., Sliepen, K., Burger, J. A., van der Woude, P., Schorcht, A., Schermer, E. E., van Gils, M. J., LaBranche, C. C., Montefiori, D. C., et al. Stabilization of the gp120 V3 loop through hydrophobic interactions reduces the immunodominant V3-directed non-neutralizing response to HIV-1 envelope trimers Journal of Biological Chemistry 2018 293:1688-1701 DOI:10.1074/jbc.RA117.000709 PMID:29222332 PMCID:PMC5798299
- Kirchdoerfer, R. N., Wang, N., Pallesen, J., Wrapp, D., Turner, H. L., Cottrell, C. A., Corbett, K. S., Graham, B. S., McLellan, J. S., Ward, A. B. Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis Scientific Reports 2018 8 DOI:10.1038/s41598-018-34171-7 PMID:30356097 PMCID:PMC6200764
- Schiffner, T., Pallesen, J., Russell, R. A., Dodd, J., de Val, N., LaBranche, C. C., Montefiori, D., Tomaras, G. D., Shen, X., Harris, S. L., Moghaddam, A. E., Kalyuzhniy, O., et al. Structural and immunologic correlates of chemically stabilized HIV-1 envelope glycoproteins PLoS Pathogens 2018 14 DOI:10.1371/journal.ppat.1006986 PMID:29746590 PMCID:PMC5944921
- Murin, C. D., Bruhn, J. F., Bornholdt, Z. A., Copps, J., Stanfield, R., Ward, A. B. Structural basis of pan-Ebolavirus neutralization by an antibody targeting the glycoprotein fusion loop Cell Reports 2018 24:2723-2732.e4 DOI:10.1016/j.celrep.2018.08.009 PMID:30184505
- Crispin, M., Ward, A. B., Wilson, I. A. Structure and immune recognition of the HIV glycan shield Annual Review of Biophysics 2018 47:499-523 DOI:10.1146/annurev-biophys-060414-034156 PMID:29595997
- Sarkar, A., Bale, S., Behrens, A. J., Kumar, S., Sharma, S. K., de Val, N., Pallesen, J., Irimia, A., Diwanji, D. C., Stanfield, R. L., Ward, A. B., Crispin, M., et al. Structure of a cleavage-independent HIV Env recapitulates the glycoprotein architecture of the native cleaved trimer Nature Communications 2018 9 DOI:10.1038/s41467-018-04272-y PMID:29769533 PMCID:PMC5955915
- Kefauver, J. M., Saotome, K., Dubin, A. E., Pallesen, J., Cottrell, C. A., Cahalan, S. M., Qiu, Z., Hong, G., Crowley, C. S., Whitwam, T., Lee, W. H., Ward, A. B., et al. Structure of the human volume regulated anion channel Elife 2018 7 DOI:10.7554/eLife.38461 PMID:30095067 PMCID:PMC6086657
- Saotome, K., Murthy, S. E., Kefauver, J. M., Whitwam, T., Patapoutian, A., Ward, A. B. Structure of the mechanically activated ion channel Piezo1 Nature 2018 554:481-486 DOI:10.1038/nature25453 PMID:29261642
- Saphire, E. O., Schendel, S. L., Fusco, M. L., Gangavarapu, K., Gunn, B. M., Wec, A. Z., Halfmann, P. J., Brannan, J. M., Herbert, A. S., Qiu, X. G., Wagh, K., He, S., et al. Systematic analysis of monoclonal antibodies against Ebola virus GP defines features that contribute to protection Cell 2018 174:938-952 DOI:10.1016/j.cell.2018.07.033 PMID:30096313 PMCID:PMC6102396
- Laursen, N. S., Friesen, R. H. E., Zhu, X., Jongeneelen, M., Blokland, S., Vermond, J., van Eijgen, A., Tang, C., van Diepen, H., Obmolova, G., Kolfschoten, M. V., Zuijdgeest, D., et al. Universal protection against influenza infection by a multidomain antibody to influenza hemagglutinin Science 2018 362:598-602 DOI:10.1126/science.aaq0620 PMID:30385580 PMCID:PMC6241527
- Dey, A. K., Cupo, A., Ozorowski, G., Sharma, V. K., Behrens, A. J., Go, E. P., Ketas, T. J., Yasmeen, A., Klasse, P. J., Sayeed, E., Desaire, H., Crispin, M., et al. cGMP production and analysis of BG505 SOSIP.664, an extensively glycosylated, trimeric HIV-1 envelope glycoprotein vaccine candidate Biotechnology and Bioengineering 2018 115:885-899 DOI:10.1002/bit.26498 PMID:29150937 PMCID:PMC5852640
- Lee, J. H., Andrabi, R., Su, C. Y., Yasmeen, A., Julien, J. P., Kong, L., Wu, N. C., McBride, R., Sok, D., Pauthner, M., Cottrell, C. A., Nieusma, T., et al. A broadly neutralizing antibody targets the dynamic HIV envelope trimer apex via a long, rigidified, and anionic β-hairpin structure Immunity 2017 46:690-702 DOI:10.1016/j.immuni.2017.03.017 PMID:28423342 PMCID:PMC5400778
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- Perz-Edwards, R. J., Irving, T. C., Baumann, B. A. J., Gore, D., Hutchinson, D. C., Krzic, U., Porter, R. L., Ward, A. B., Reedy, M. K. X-ray diffraction evidence for myosin-troponin connections and tropomyosin movement during stretch activation of insect flight muscle Proceedings of the National Academy of Sciences of the United States of America 2011 108:120-125 DOI:10.1073/pnas.1014599107 PMID:21148419 PMCID:PMC3017141
- Glaves, J. P., Fisher, L., Ward, A., Young, H. S. Helical crystallization of two example membrane proteins MsbA and the Ca(2+)-ATPase Methods in Enzymology 2010 483:143-159 DOI:10.1016/s0076-6879(10)83007-1 PMID:20888473
- Gutmann, D. A. P., Ward, A., Urbatsch, I. L., Chang, G., van Veen, H. W. Understanding polyspecificity of multidrug ABC transporters: closing in on the gaps in ABCB1 Trends in Biochemical Sciences 2010 35:36-42 DOI:10.1016/j.tibs.2009.07.009 PMID:19819701 PMCID:PMC4608440
- Ward, A., Mulligan, S., Carragher, B., Chang, G., Milligan, R. A. Nucleotide dependent packing differences in helical crystals of the ABC transporter MsbA Journal of Structural Biology 2009 165:169-175 DOI:10.1016/j.jsb.2008.11.006 PMID:19114108 PMCID:PMC2703300
- Aller, S. G., Yu, J., Ward, A., Weng, Y., Chittaboina, S., Zhuo, R. P., Harrell, P. M., Trinh, Y. T., Zhang, Q. H., Urbatsch, I. L., Chang, G. Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding Science 2009 323:1718-1722 DOI:10.1126/science.1168750 PMID:19325113 PMCID:PMC2720052
- Bekyarova, T. I., Reedy, M. C., Baumann, B. A. J., Tregear, R. T., Ward, A., Krzic, U., Prince, K. M., Perz-Edwards, R. J., Reconditi, M., Gore, D., Irving, T. C., Reedy, M. K. Reverse actin sliding triggers strong myosin binding that moves tropomyosin Proceedings of the National Academy of Sciences of the United States of America 2008 105:10372-10377 DOI:10.1073/pnas.0709877105 PMID:18658238 PMCID:PMC2492518
- Littlefield, K. P., Ward, A. B., Chappie, J. S., Reedy, M. K., Bernstein, S. I., Milligan, R. A., Reedy, M. C. Similarities and differences between frozen-hydrated, rigor acto-S1 complexes of insect flight and chicken skeletal muscles Journal of Molecular Biology 2008 381:519-528 DOI:10.1016/j.jmb.2008.06.029 PMID:18588896 PMCID:PMC2567842
- Zhang, Q. H., Ma, X. Q., Ward, A., Hong, W. X., Jaakola, V. P., Stevens, R. C., Finn, M. G., Chang, G. Designing facial amphiphiles for the stabilization of integral membrane proteins Angewandte Chemie-International Edition 2007 46:7023-7025 DOI:10.1002/anie.200701556 PMID:17691085
- Ward, A., Reyes, C. L., Yu, J., Roth, C. B., Chang, G. Flexibility in the ABC transporter MsbA: Alternating access with a twist Proceedings of the National Academy of Sciences of the United States of America 2007 104:19005-19010 DOI:10.1073/pnas.0709388104 PMID:18024585 PMCID:PMC2141898
- Reyes, C. L., Ward, A., Yu, J., Chang, G. The structures of MsbA: Insight into ABC transporter-mediated multidrug efflux FEBS Letters 2006 580:1042-1048 DOI:10.1016/j.febslet.2005.11.033 PMID:16337944
- Ward, A., Moody, M. F., Sheehan, B., Milligan, R. A., Carragher, B. Windex: A toolset for indexing helices Journal of Structural Biology 2003 144:172-183 DOI:10.1016/j.jsb.2003.10.008 PMID:14643220

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