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Ward, Andrew
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Ward, Andrew

Faculty Member
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Positions

  • 2017 - Professor, Integrative Structural and Computational Biology (ISCB) , Scripps Research
  • 2010 - Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
  • 2015 - 2017 Associate Professor, Integrative Structural and Computational Biology (ISCB) , Scripps Research
  • 2013 - 2015 Assistant Professor, Integrative Structural and Computational Biology (ISCB) , Scripps Research
  • 2010 - 2012 Assistant Professor, Molecular Biology , Scripps Research
  • 2008 - 2010 Research Associate with Dr. Geoffrey Chang, Molecular Biology , Scripps Research

Contact

  • andrew@scripps.edu

Websites

  • Andrew Ward, Ph.D.
  • Doctoral Dissertation
  • Laboratory Website
  • Twitter @WardLab1
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Publications

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  • 81

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    • Guthmiller, J. J., Han, J. L. N., Utset, H. A., Li, L., Lan, Ldyl, Henry, C., Stamper, C. T., McMahon, M., O'Dell, G., Fernandez-Quintero, M. L., Freyn, A. W., Amanat, F., et al. Broadly neutralizing antibodies target a haemagglutinin anchor epitope Nature  2022  DOI:10.1038/s41586-021-04356-8  PMID:34942633  PMCID:PMC8828479
    • Antanasijevic, A., Bowman, C. A., Kirchdoerfer, R. N., Cottrell, C. A., Ozorowski, G., Upadhyay, A. A., Cirelli, K. M., Carnathan, D. G., Enemuo, C. A., Sewall, L. M., Nogal, B., Zhao, F., et al. From structure to sequence: Antibody discovery using cryoEM Science Advances  2022 8  DOI:10.1126/sciadv.abk2039  PMID:35044813  PMCID:PMC8769551
    • van Schooten, J., van Haaren, M. M., Li, H., McCoy, L. E., Havenar-Daughton, C., Cottrell, C. A., Burger, J. A., van der Woude, P., Helgers, L. C., Tomris, I., Labranche, C. C., Montefiori, D. C., et al. Antibody responses induced by SHIV infection are more focused than those induced by soluble native HIV-1 envelope trimers in non-human primates PLoS Pathogens  2021 17  DOI:10.1371/journal.ppat.1009736  PMID:34432859  PMCID:PMC8423243
    • Antanasijevic, A., Sewall, L. M., Cottrell, C. A., Carnathan, D. G., Jimenez, L. E., Ngo, J. T., Silverman, J. B., Groschel, B., Georgeson, E., Bhiman, J., Bastidas, R., LaBranche, C., et al. Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM Nature Communications  2021 12  DOI:10.1038/s41467-021-25087-4  PMID:34376662  PMCID:PMC8355326
    • Turner, H. L., Andrabi, R., Cottrell, C. A., Richey, S. T., Song, G., Callaghan, S., Anzanello, F., Moyer, T. J., Abraham, W., Melo, M., Silva, M., Scaringi, N., et al. Disassembly of HIV envelope glycoprotein trimer immunogens is driven by antibodies elicited via immunization Science Advances  2021 7  DOI:10.1126/sciadv.abh2791  PMID:34321200  PMCID:PMC8318364
    • Amanat, F., Strohmeier, S., Lee, W. H., Bangaru, S., Ward, A. B., Coughlan, L., Krammer, F. Murine Monoclonal Antibodies against the Receptor Binding Domain of SARS-CoV-2 Neutralize Authentic Wild-Type SARS-CoV-2 as Well as B.1.1.7 and B.1.351 Viruses and Protect In Vivo in a Mouse Model in a Neutralization-Dependent Manner mBio  2021 12  DOI:10.1128/mBio.01002-21  PMID:34311574  PMCID:PMC8406178
    • Kumar, S., Lin, X., Ngo, T., Shapero, B., Sou, C., Allen, J. D., Copps, J., Zhang, L., Ozorowski, G., He, L. L., Crispin, M., Ward, A. B., et al. Neutralizing Antibodies Induced by First-Generation gp41-Stabilized HIV-1 Envelope Trimers and Nanoparticles mBio  2021 12  DOI:10.1128/mBio.00429-21  PMID:34156262  PMCID:PMC8262854
    • Guthmiller, Jenna J., Han, Julianna and Li, Lei, Freyn, Alec W., Liu, Sean T. H., Stovicek, Olivia, Stamper, Christopher T., Dugan, Haley L., Tepora, Micah E., Utset, Henry A., Bitar, Dalia J., Hamel, Natalie J., Changrob, Siriruk and Zheng, Nai-Ying, et al. First exposure to the pandemic H1N1 virus induced broadly neutralizing antibodies targeting hemagglutinin head epitopes Science Translational Medicine  2021 13  DOI:10.1126/scitranslmed.abg4535  PMID:34078743
    • Rossignol, Evan D., Dugast, Anne-Sophie and Compere, Hacheming, Cottrell, Christopher A., Copps, Jeffrey and Lin, Shu, Cizmeci, Deniz, Seaman, Michael S., Ackerman, Margaret E., Ward, A., Alter, Galit and Julg, Boris Mining HIV controllers for broad and functional antibodies to recognize and eliminate HIV-infected cells Cell Reports  2021 35  DOI:10.1016/j.celrep.2021.109167  PMID:34038720  PMCID:PMC8196545
    • Yuan, M., Huang, D. L., Lee, C. C. D., Wu, N. C., Jackson, A. M., Zhu, X. Y., Liu, H. J., Peng, L. (141479, Van Gils, M. J., Sanders, R. W., Burton, D. R., Reincke, S. M., et al. Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants Science  2021 373:818-+  DOI:10.1126/science.abh1139  PMID:34016740  PMCID:PMC8284396
    • Song, G., He, Wan-ting and Callaghan, Sean, Anzanello, Fabio and Huang, Deli, Ricketts, James, Torres, Jonathan L., Beutler, N., Peng, L., Vargas, Sirena and Cassell, Jon, Parren, Mara and Yang, Linlin, Ignacio, Caroline, Smith, Davey M., Voss, J. E., et al. Cross-reactive serum and memory B-cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infection Nature Communications  2021 12  DOI:10.1038/s41467-021-23074-3  PMID:34011939  PMCID:PMC8134462
    • He, Linling and Chaudhary, Anshul, Lin, X., Sou, Cindy, Alkutkar, T., Kumar, Sonu and Ngo, Timothy, Kosviner, Ezra and Ozorowski, Gabriel, Stanfield, R. L., Ward, A. B., Wilson, I. A., Zhu, J. Single-component multilayered self-assembling nanoparticles presenting rationally designed glycoprotein trimers as Ebola virus vaccines Nature Communications  2021 12  DOI:10.1038/s41467-021-22867-w  PMID:33976149  PMCID:PMC8113551
    • Liu, H. J., Yuan, M., Huang, D. L., Bangaru, S., Zhao, F., Lee, C. C. D., Peng, L., Barman, S., Zhu, X. Y., Nemazee, D., Burton, D. R., van Gils, M. J., et al. A combination of cross-neutralizing antibodies synergizes to prevent SARS-CoV-2 and SARS-CoV pseudovirus infection Cell Host & Microbe  2021 29:806-818  DOI:10.1016/j.chom.2021.04.005  PMID:33894127  PMCID:PMC8049401
    • Murin, C. D., Gilchuk, P., Ilinykh, P. A., Huang, K., Kuzmina, N., Shen, X. L., Bruhn, J. F., Bryan, A. L., Davidson, E., Doranz, B. J., Williamson, L. E., Copps, J., et al. Convergence of a common solution for broad ebolavirus neutralization by glycan cap-directed human antibodies Cell Reports  2021 35  DOI:10.1016/j.celrep.2021.108984  PMID:33852862  PMCID:PMC8133395
    • Kumar, R., Deshpande, S., Sewall, L. M., Ozorowski, G., Cottrell, C. A., Lee, W. H., Holden, L. G., Richey, S. T., Chandrawacar, A. S., Dhiman, K., Ashish, F., Kumar, V., et al. Elicitation of potent serum neutralizing antibody responses in rabbits by immunization with an HIV-1 clade C trimeric Env derived from an Indian elite neutralizer PLoS Pathogens  2021 17  DOI:10.1371/journal.ppat.1008977  PMID:33826683  PMCID:PMC8055034
    • Derking, R., Allen, J. D., Cottrell, C. A., Sliepen, K., Seabright, G. E., Lee, W. H., Aldon, Y., Rantalainen, K., Antanasijevic, A., Copps, J., Yasmeen, A., Cupo, A., et al. Enhancing glycan occupancy of soluble HIV-1 envelope trimers to mimic the native viral spike Cell Reports  2021 35  DOI:10.1016/j.celrep.2021.108933  PMID:33826885
    • Lee, C. C. D., Watanabe, Y., Wu, N. C., Han, J., Kumar, S., Pholcharee, T., Seabright, G. E., Allen, J. D., Lin, C. W., Yang, J. R., Liu, M. T., Wu, C. Y., et al. A cross-neutralizing antibody between HIV-1 and influenza virus PLoS Pathogens  2021 17  DOI:10.1371/journal.ppat.1009407  PMID:33750987  PMCID:PMC8016226
    • Andreano, E., Nicastri, E., Paciello, I., Pileri, P., Manganaro, N., Piccini, G., Manenti, A., Pantano, E., Kabanova, A., Troisi, M., Vacca, F., Cardamone, D., et al. Extremely potent human monoclonal antibodies from COVID-19 convalescent patients Cell  2021 184:1821-1835  DOI:10.1016/j.cell.2021.02.035  PMID:33667349  PMCID:PMC7901298
    • Freyn, A. W., Han, J. L. N., Guthmiller, J. J., Bailey, M. J., Neu, K., Turner, H. L., Rosado, V. C., Chromikova, V., Huang, M., Strohmeier, S., Liu, S. T. H., Simon, V., et al. Influenza hemagglutinin-specific IgA Fc-effector functionality is restricted to stalk epitopes Proceedings of the National Academy of Sciences of the United States of America  2021 118  DOI:10.1073/pnas.2018102118  PMID:33593910  PMCID:PMC7923359
    • Brouwer, P. J. M., Antanasijevic, A., de Gast, M., Allen, J. D., Bijl, T. P. L., Yasmeen, A., Ravichandran, R., Burger, J. A., Ozorowski, G., Torres, J. L., LaBranche, C., Montefiori, D. C., et al. Immunofocusing and enhancing autologous Tier-2 HIV-1 neutralization by displaying Env trimers on two-component protein nanoparticles NPJ Vaccines  2021 6  DOI:10.1038/s41541-021-00285-9  PMID:33563983  PMCID:PMC7873233
    • Bouwman, K. M., Tomris, I., Turner, H. L., van der Woude, R., Shamorkina, T. M., Bosman, G. P., Rockx, B., Herfst, S., Snijder, J., Haagmans, B. L., Ward, A. B., Boons, G. J., et al. Multimerization- and glycosylation-dependent receptor binding of SARS-CoV-2 spike proteins PLoS Pathogens  2021 17  DOI:10.1371/journal.ppat.1009282  PMID:33556147  PMCID:PMC7895411
    • Charles, T. P., Burton, S. L., Arunachalam, P. S., Cottrell, C. A., Sewall, L. M., Bollimpelli, V. S., Gangadhara, S., Dey, A. K., Ward, A. B., Shaw, G. M., Hunter, E., Amara, R. R., et al. The C3/465 glycan hole cluster in BG505 HIV-1 envelope is the major neutralizing target involved in preventing mucosal SHIV infection PLoS Pathogens  2021 17  DOI:10.1371/journal.ppat.1009257  PMID:33556148  PMCID:PMC7895394
    • Wang, Y. M., Howell, K. A., Brannan, J., Agans, K. N., Turner, H. L., Wirchnianski, A. S., Kailasan, S., Fusco, M., Galkin, A., Chiang, C. I., Zhao, X. L., Saphire, E. O., et al. Prominent Neutralizing Antibody Response Targeting the Ebolavirus Glycoprotein Subunit Interface Elicited by Immunization Journal of Virology  2021 95  DOI:10.1128/jvi.01907-20  PMID:33536172  PMCID:PMC8103683
    • Han, J., Schmitz, A. J., Richey, S. T., Dai, Y. N., Turner, H. L., Mohammed, B. M., Fremont, D. H., Ellebedy, A. H., Ward, A. B. Polyclonal epitope mapping reveals temporal dynamics and diversity of human antibody responses to H5N1 vaccination Cell Reports  2021 34  DOI:10.1016/j.celrep.2020.108682  PMID:33503432  PMCID:PMC7888560
    • Brouwer, P. J. M., Brinkkemper, M., Maisonnasse, P., Dereuddre-Bosquet, N., Grobben, M., Claireaux, M., de Gast, M., Marlin, R., Chesnais, V., Diry, S., Allen, J. D., Watanabe, Y., et al. Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection Cell  2021 184:1188-1200  DOI:10.1016/j.cell.2021.01.035  PMID:33577765  PMCID:PMC7834972
    • Dingens, A. S., Pratap, P., Malone, K., Hilton, S. K., Ketas, T., Cottrell, C. A., Overbaugh, J., Moore, J. P., Klasse, P. J., Ward, A. B., Bloom, J. D. High-resolution mapping of the neutralizing and binding specificities of polyclonal sera post-HIV Env trimer vaccination eLife  2021 10  DOI:10.7554/eLife.64281  PMID:33438580  PMCID:PMC7864656
    • van Haaren, M. M., McCoy, L. E., Torres, J. L., Lee, W., Cottrell, C. A., Copps, J. L., van der Woude, P., Yasmeen, A., de Taeye, S. W., de la Pena, A. T., Moore, J. P., Burton, D. R., et al. Antibodies from Rabbits Immunized with HIV-1 Clade B SOSIP Trimers Can Neutralize Multiple Clade B Viruses by Destabilizing the Envelope Glycoprotein Journal of Virology  2021 95  DOI:10.1128/JVI.00094-21.2June2021  PMID:34076487  PMCID:PMC8354326
    • Cho, H., Gonzales-Wartz, K. K., Huang, D. L., Yuan, M., Peterson, M., Liang, J., Beutler, N., Torres, J. L., Cong, Y., Postnikova, E., Bangaru, S., Talana, C. A., et al. Bispecific antibodies targeting distinct regions of the spike protein potently neutralize SARS-CoV-2 variants of concern Science Translational Medicine  2021 13  DOI:10.1126/scitranslmed.abj5413  PMID:34519517  PMCID:PMC8651051
    • Gilchuk, I. M., Bangaru, S., Kose, N., Bombardi, R. G., Trivette, A., Li, S., Turner, H. L., Carnahan, R. H., Ward, A. B., Crowe, J. E. Human antibody recognition of H7N9 influenza virus HA following natural infection JCI Insight  2021 6  DOI:10.1172/jci.insight.152403  PMID:34437301  PMCID:PMC8525637
    • Gu, M. G., Torres, J. L., Li, Y. J., Van Ry, A., Greenhouse, J., Wallace, S., Chiang, C. I., Pessaint, L., Jackson, A. M., Porto, M., Kar, S., Li, Y. X., et al. One dose of COVID-19 nanoparticle vaccine REVC-128 protects against SARS-CoV-2 challenge at two weeks post-immunization Emerging Microbes & Infections  2021 10:2016-2029  DOI:10.1080/22221751.2021.1994354  PMID:34651563  PMCID:PMC8567933
    • Cottrell, C. A., Manne, K., Kong, R., Wang, S. S., Zhou, T. Q., Chuang, G. Y., Edwards, R. J., Henderson, R., Janowska, K., Kopp, M., Lin, B. C., Louder, M. K., et al. Structural basis of glycan276-dependent recognition by HIV-1 broadly neutralizing antibodies Cell Reports  2021 37  DOI:10.1016/j.celrep.2021.109922  PMID:34731616
    • Kirchdoerfer, R. N., Bhandari, M., Martini, O., Sewall, L. M., Bangaru, S., Yoon, K. J., Ward, A. B. Structure and immune recognition of the porcine epidemic diarrhea virus spike protein Structure  2020 29:385-392  DOI:10.1016/j.str.2020.12.003  PMID:33378641  PMCID:PMC7962898
    • Liu, H. J., Wu, N. C., Yuan, M., Bangaru, S., Torres, J. L., Caniels, T. G., van Schooten, J., Zhu, X. Y., Lee, C. C. D., Brouwer, P. J. M., van Gils, M. J., Sanders, R. W., et al. Cross-Neutralization of a SARS-CoV-2 Antibody to a Functionally Conserved Site Is Mediated by Avidity Immunity  2020 53:1272-1280  DOI:10.1016/j.immuni.2020.10.023  PMID:33242394  PMCID:PMC7687367
    • Kefauver, J. M., Ward, A. B., Patapoutian, A. Discoveries in structure and physiology of mechanically activated ion channels Nature  2020 587:567-576  DOI:10.1038/s41586-020-2933-1  PMID:33239794
    • Ozorowski, G., Torres, J. L., Santos-Martins, D., Forli, S., Ward, A. B. A Strain-Specific Inhibitor of Receptor-Bound HIV-1 Targets a Pocket near the Fusion Peptide Cell Reports  2020 33  DOI:10.1016/j.celrep.2020.108428  PMID:33238117  PMCID:PMC7701285
    • Schorcht, Anna, van den Kerkhof, Tom L. G. M., Cottrell, C., Allen, Joel D., Torres, Jonathan L., Behrens, Anna-Janina, Schermer, Edith E., Burger, Judith A., de Taeye, Steven W., de la Pena, Alba Torrents and Bontjer, Ilja, Gumbs, Stephanie and Ozorowski, Gabriel, LaBranche, Celia C., et al. Neutralizing Antibody Responses Induced by HIV-1 Envelope Glycoprotein SOSIP Trimers Derived from Elite Neutralizers Journal of Virology  2020 94  DOI:10.1128/jvi.01214-20  PMID:32999024  PMCID:PMC7925178
    • Chakraborty, S., Berndsen, Z. T., Hengartner, N. W., Korber, B. T., Ward, A. B., Gnanakaran, S. Quantification of the Resilience and Vulnerability of HIV-1 Native Glycan Shield at Atomistic Detail iScience  2020 23  DOI:10.1016/j.isci.2020.101836  PMID:33319171  PMCID:PMC7724196
    • Guthmiller, J. J., Lan, Ldyl, Fernandez-Quintero, M. L., Han, J., Utset, H. A., Bitar, D. J., Hamel, N. J., Stovicek, O., Li, L., Tepora, M., Henry, C., Neu, K. E., et al. Polyreactive Broadly Neutralizing B cells Are Selected to Provide Defense against Pandemic Threat Influenza Viruses Immunity  2020 53:1230-1244  DOI:10.1016/j.immuni.2020.10.005  PMID:33096040  PMCID:PMC7772752
    • Berndsen, Z. T., Chakraborty, S., Wang, X. N., Cottrell, C. A., Torres, J. L., Diedrich, J. K., Lopez, C. A., Yates III, J. R., van Gils, M. J., Paulson, J. C., Gnanakaran, S., Ward, A. B. Visualization of the HIV-1 Env glycan shield across scales Proceedings of the National Academy of Sciences of the United States of America  2020 117:28014-28025  DOI:10.1073/pnas.2000260117  PMID:33093196  PMCID:PMC7668054
    • Bangaru, S., Ozorowski, G., Turner, H. L., Antanasijevic, A., Huang, D. L., Wang, X. N., Torres, J. L., Diedrich, J. K., Tian, J. H., Portnoff, A. D., Patel, N., Massare, M. J., et al. Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate Science  2020 370:1089-1094  DOI:10.1126/science.abe1502  PMID:33082295  PMCID:PMC7857404
    • Wu, N. C., Yuan, M., Liu, H., Lee, C. C. D., Zhu, X., Bangaru, S., Torres, J. L., Caniels, T. G., Brouwer, P. J. M., van Gils, M. J., Sanders, R. W., Ward, A. B., et al. An Alternative Binding Mode of IGHV3-53 Antibodies to the SARS-CoV-2 Receptor Binding Domain Cell Reports  2020 33  DOI:10.1016/j.celrep.2020.108274  PMID:33027617  PMCID:PMC7522650
    • Clausen, T. M., Sandoval, D. R., Spliid, C. B., Pihl, J., Perrett, H. R., Painter, C. D., Narayanan, A., Majowicz, S. A., Kwong, E. M., McVicar, R. N., Thacker, B. E., Glass, C. A., et al. SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2 Cell  2020 183:1043-1057  DOI:10.1016/j.cell.2020.09.033  PMID:32970989  PMCID:PMC7489987
    • Zhao, F., Joyce, C., Burns, A., Nogal, B., Cottrell, C. A., Ramos, A., Biddle, T., Pauthner, M., Nedellec, R., Qureshi, H., Mason, R., Landais, E., et al. Mapping Neutralizing Antibody Epitope Specificities to an HIV Env Trimer in Immunized and in Infected Rhesus Macaques Cell Reports  2020 32  DOI:10.1016/j.celrep.2020.108122  PMID:32905766  PMCID:PMC7487785
    • Dong, J. H., Gilchuk, I., Li, S., Irving, R., Goff, M. T., Turner, H. L., Ward, A. B., Carnahan, R. H., Crowe, J. E. Anti-influenza H7 human antibody targets antigenic site in hemagglutinin head domain interface Journal of Clinical Investigation  2020 130:4734-4739  DOI:10.1172/jci136032  PMID:32749241  PMCID:PMC7456233
    • van der Woude, R., Turner, H. L., Tomris, I., Bouwman, K. M., Ward, A. B., de Vries, R. P. Drivers of recombinant soluble influenza A virus hemagglutinin and neuraminidase expression in mammalian cells Protein Science  2020 29:1975-1982  DOI:10.1002/pro.3918  PMID:32710576  PMCID:PMC7454420
    • Turner, J. S., Zhou, J. Q., Han, J., Schmitz, A. J., Rizk, A. A., Alsoussi, W. B., Lei, T. T., Amor, M., McIntire, K. M., Meade, P., Strohmeier, S., Brent, R. I., et al. Human germinal centres engage memory and naive B cells after influenza vaccination Nature  2020 586:127-132  DOI:10.1038/s41586-020-2711-0  PMID:32866963
    • Cottrell, C. A., van Schooten, J., Bowman, C. A., Yuan, M., Oyen, D., Shin, M., Morpurgo, R., van der Woude, P., van Breemen, M., Torres, J. L., Patel, R., Gross, J., et al. Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates PLoS Pathogens  2020 16  DOI:10.1371/journal.ppat.1008753  PMID:32866207  PMCID:PMC7485981
    • Antanasijevic, A., Ueda, G., Brouwer, P. J. M., Copps, J., Huang, D. L., Allen, J. D., Cottrell, C. A., Yasmeen, A., Sewall, L. M., Bontjer, I., Ketas, T. J., Turner, H. L., et al. Structural and functional evaluation ofde novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens PLoS Pathogens  2020 16  DOI:10.1371/journal.ppat.1008665  PMID:32780770  PMCID:PMC7418955
    • Brouwer, P. J. M., Caniels, T. G., van der Straten, K., Snitselaar, J. L., Aldon, Y., Bangaru, S., Torres, J. L., Okba, N. M. A., Claireaux, M., Kerster, G., Bentlage, A. E. H., van Haaren, M. M., et al. Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability Science  2020 369:643-650  DOI:10.1126/science.abc5902  PMID:32540902  PMCID:PMC7299281
    • Martin, J. T., Cottrell, C. A., Antanasijevic, A., Carnathan, D. G., Cossette, B. J., Enemuo, C. A., Gebru, E. H., Choe, Y., Viviano, F., Fischinger, S., Tokatlian, T., Cirelli, K. M., et al. Targeting HIV Env immunogens to B cell follicles in nonhuman primates through immune complex or protein nanoparticle formulations NPJ Vaccines  2020 5  DOI:10.1038/s41541-020-00223-1  PMID:32802411  PMCID:PMC7406516
    • Seabright, G. E., Cottrell, C. A., van Gils, M. J., D'Addabbo, A., Harvey, D. J., Behrens, A. J., Allen, J. D., Watanabe, Y., Scaringi, N., Polveroni, T. M., Maker, A., Vasiljevic, S., et al. Networks of HIV-1 Envelope Glycans Maintain Antibody Epitopes in the Face of Glycan Additions and Deletions Structure  2020 28:897-906  DOI:10.1016/j.str.2020.04.022  PMID:32433992  PMCID:PMC7416112
    • Ueda, G., Antanasijevic, A., Fallas, J. A., Sheffler, W., Copps, J., Ellis, D., Hutchinson, G. B., Moyer, A., Yasmeen, A., Tsybovsky, Y., Park, Y. J., Bick, M. J., et al. Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens eLife  2020 9  DOI:10.7554/eLife.57659  PMID:32748788  PMCID:PMC7402677
    • Ellebedy, A. H., Nachbagauer, R., Jackson, K. J. L., Dai, Y. N., Han, J., Alsoussi, W. B., Davis, C. W., Stadlbauer, D., Rouphael, N., Chromikova, V., McCausland, M., Chang, C. Y., et al. Adjuvanted H5N1 influenza vaccine enhances both cross-reactive memory B cell and strain-specific naive B cell responses in humans Proceedings of the National Academy of Sciences of the United States of America  2020 117:17957-17964  DOI:10.1073/pnas.1906613117  PMID:32661157  PMCID:PMC7395544
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    • Ringe, R. P., Sanders, R. W., Yasmeen, A., Kim, H. J., Lee, J. H., Cupo, A., Korzun, J., Derking, R., van Montfort, T., Julien, J. P., Wilson, I. A., Klasse, P. J., et al. Cleavage strongly influences whether soluble HIV-1 envelope glycoprotein trimers adopt a native-like conformation Proceedings of the National Academy of Sciences of the United States of America  2013 110:18256-18261  DOI:10.1073/pnas.1314351110  PMID:24145402  PMCID:PMC3831437
    • Hong, M., Lee, P. S., Hoffman, R. M. B., Zhu, X., Krause, J. C., Laursen, N. S., Yoon, S. I., Song, L., Tussey, L., Crowe, J. E., Ward, A. B., Wilson, I. A. Antibody recognition of the pandemic H1N1 Influenza virus hemagglutinin receptor binding site Journal of Virology  2013 87:12471-12480  DOI:10.1128/jvi.01388-13  PMID:24027321  PMCID:PMC3807900
    • Julien, J. P., Sok, D., Khayat, R., Lee, J. H., Doores, K. J., Walker, L. M., Ramos, A., Diwanji, D. C., Pejchal, R., Cupo, A., Katpally, U., Depetris, R. S., et al. Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans PLoS Pathogens  2013 9:e1003342  DOI:10.1371/journal.ppat.1003342  PMID:23658524  PMCID:PMC3642082
    • Klasse, P. J., Depetris, R. S., Pejchal, R., Julien, J. P., Khayat, R., Lee, J. H., Marozsan, A. J., Cupo, A., Cocco, N., Korzun, J., Yasmeen, A., Ward, A. B., et al. Influences on Trimerization and Aggregation of Soluble, Cleaved HIV-1 SOSIP Envelope Glycoprotein Journal of Virology  2013 87:9873-9885  DOI:10.1128/jvi.01226-13  PMID:23824824  PMCID:PMC3754145
    • Khayat, R., Lee, J. H., Julien, J. P., Cupo, A., Klasse, P. J., Sanders, R. W., Moore, J. P., Wilson, I. A., Ward, A. B. Structural characterization of cleaved, soluble HIV-1 envelope glycoprotein trimers Journal of Virology  2013 87:9865-9872  DOI:10.1128/jvi.01222-13  PMID:23824817  PMCID:PMC3754114
    • Ward, A. B., Szewczyk, P., Grimard, V., Lee, C. W., Martinez, L., Doshi, R., Caya, A., Villaluz, M., Pardon, E., Cregger, C., Swartz, D. J., Falson, P. G., et al. Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain Proceedings of the National Academy of Sciences of the United States of America  2013 110:13386-13391  DOI:10.1073/pnas.1309275110  PMID:23901103  PMCID:PMC3746859
    • Kong, L., Lee, J. H., Doores, K. J., Murin, C. D., Julien, J. P., McBride, R., Liu, Y., Marozsan, A., Cupo, A., Klasse, P. J., Hoffenberg, S., Caulfield, M., et al. Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120 Nature Structural & Molecular Biology  2013 20:796-803  DOI:10.1038/nsmb.2594  PMID:23708606  PMCID:PMC3823233
    • Jardine, J., Julien, J. P., Menis, S., Ota, T., Kalyuzhniy, O., McGuire, A., Sok, D., Huang, P. S., MacPherson, S., Jones, M., Nieusma, T., Mathison, J., et al. Rational HIV immunogen design to target specific germline B cell receptors Science  2013 340:711-716  DOI:10.1126/science.1234150  PMID:23539181  PMCID:PMC3689846
    • Lee, S. C., Bennett, B. C., Hong, W. X., Fu, Y., Baker, K. A., Marcoux, J., Robinson, C. V., Ward, A. B., Halpert, J. R., Stevens, R. C., Stout, C. D., Yeager, M. J., et al. Steroid-based facial amphiphiles for stabilization and crystallization of membrane proteins Proceedings of the National Academy of Sciences of the United States of America  2013 110:E1203-11  DOI:10.1073/pnas.1221442110  PMID:23479627  PMCID:PMC3612649
    • Julien, J. P., Lee, J. H., Cupo, A., Murin, C. D., Derking, R., Hoffenberg, S., Caulfield, M. J., King, C. R., Marozsan, A. J., Klasse, P. J., Sanders, R. W., Moore, J. P., et al. Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9 Proceedings of the National Academy of Sciences of the United States of America  2013 110:213-218  DOI:10.1073/pnas.1217537110  PMID:23426631  PMCID:PMC3600498
    • Sanders, R. W., Derking, R., Cupo, A., Julien, J. P., Yasmeen, A., de Val, N., Kim, H. J., Blattner, C., de la Pena, A. T., Korzun, J., Golabek, M., de los Reyes, K., et al. A next-generation cleaved, soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies PLoS Pathogens  2013 9:e1003618  DOI:10.1371/journal.ppat.1003618  PMID:24068931  PMCID:PMC3777863
    • Ward, A. B., Sali, A., Wilson, I. A. Biochemistry. Integrative structural biology Science  2013 339:913-915  DOI:10.1126/science.1228565  PMID:23430643  PMCID:PMC3633482
    • Thornburg, N. J., Nannemann, D. P., Blum, D. L., Belser, J. A., Tumpey, T. M., Deshpande, S., Fritz, G. A., Sapparapu, G., Krause, J. C., Lee, J. H., Ward, A. B., Lee, D. E., et al. Human antibodies that neutralize respiratory droplet transmissible H5N1 influenza viruses Journal of Clinical Investigation  2013 123:4405-4409  DOI:10.1172/jci69377  PMID:23999429  PMCID:PMC3784541
    • Burton, D. R., Ahmed, R., Barouch, D. H., Butera, S. T., Crotty, S., Godzik, A., Kaufmann, D. E., McElrath, M. J., Nussenzweig, M. C., Pulendran, B., Scanlan, C. N., Schief, W. R., et al. A blueprint for HIV vaccine discovery Cell Host & Microbe  2012 12:396-407  DOI:10.1016/j.chom.2012.09.008  PMID:23084910  PMCID:PMC3513329
    • Ekiert, D. C., Kashyap, A. K., Steel, J., Rubrum, A., Bhabha, G., Khayat, R., Lee, J. H., Dillon, M. A., O'Neil, R. E., Faynboym, A. M., Horowitz, M., Horowitz, L., et al. Cross-neutralization of influenza a viruses mediated by a single antibody loop Nature  2012 489:526-32  DOI:10.1038/nature11414  PMID:22982990  PMCID:PMC3538848
    • Dreyfus, C., Laursen, N. S., Kwaks, T., Zuijdgeest, D., Khayat, R., Ekiert, D. C., Lee, J. H., Metlagel, Z., Bujny, M. V., Jongeneelen, M., van der Vlugt, R., Lamrani, M., et al. Highly conserved protective epitopes on influenza B viruses Science  2012 337:1343-1348  DOI:10.1126/science.1222908  PMID:22878502  PMCID:PMC3538841
    • degree-related publication Ward, A. B., Guvench, O., Hills, R. D. Coarse grain lipid-protein molecular interactions and diffusion with MsbA flippase Proteins-Structure Function and Bioinformatics  2012 80:2178-2190  DOI:10.1002/prot.24108  PMID:22552999
    • Depetris, R. S., Julien, J. P., Khayat, R., Lee, J. H., Pejchal, R., Katpally, U., Cocco, N., Kachare, M., Massi, E., David, K. B., Cupo, A., Marozsan, A. J., et al. Partial enzymatic deglycosylation preserves the structure of cleaved recombinant HIV-1 envelope glycoprotein trimers Journal of Biological Chemistry  2012 287:24239-24254  DOI:10.1074/jbc.M112.371898  PMID:22645128  PMCID:PMC3397850
    • McLellan, J. S., Pancera, M., Carrico, C., Gorman, J., Julien, J. P., Khayat, R., Louder, R., Pejchal, R., Sastry, M., Dai, K. F., O'Dell, S., Patel, N., et al. Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9 Nature  2011 480:336-343  DOI:10.1038/nature10696  PMID:22113616  PMCID:PMC3406929
    • degree-related publication Fisher, L. S., Ward, A., Milligan, R. A., Unwin, N., Potter, C. S., Carragher, B. A helical processing pipeline for EM structure determination of membrane proteins Methods  2011 55:350-362  DOI:10.1016/j.ymeth.2011.09.013  PMID:21964395  PMCID:PMC3262078
    • Pejchal, R., Doores, K. J., Walker, L. M., Khayat, R., Huang, P. S., Wang, S. K., Stanfield, R. L., Julien, J. P., Ramos, A., Crispin, M., Depetris, R., Katpally, U., et al. A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield Science  2011 334:1097-1103  DOI:10.1126/science.1213256  PMID:21998254  PMCID:PMC3280215
    • Bai, J. P., Swartz, D. J., Protasevich, II, Brouillette, C. G., Harrell, P. M., Hildebrandt, E., Gasser, B., Mattanovich, D., Ward, A., Chang, G., Urbatsch, I. L. A gene optimization strategy that enhances production of fully functional p-glycoprotein in pichia pastoris PLoS One  2011 6:e22577  DOI:10.1371/journal.pone.0022577  PMID:21826197  PMCID:PMC3149604
    • degree-related publication Perz-Edwards, R. J., Irving, T. C., Baumann, B. A. J., Gore, D., Hutchinson, D. C., Krzic, U., Porter, R. L., Ward, A. B., Reedy, M. K. X-ray diffraction evidence for myosin-troponin connections and tropomyosin movement during stretch activation of insect flight muscle Proceedings of the National Academy of Sciences of the United States of America  2011 108:120-125  DOI:10.1073/pnas.1014599107  PMID:21148419  PMCID:PMC3017141
    • degree-related publication Glaves, J. P., Fisher, L., Ward, A., Young, H. S. Helical crystallization of two example membrane proteins MsbA and the Ca(2+)-ATPase Methods in Enzymology  2010 483:143-159  DOI:10.1016/s0076-6879(10)83007-1  PMID:20888473
    • Gutmann, D. A. P., Ward, A., Urbatsch, I. L., Chang, G., van Veen, H. W. Understanding polyspecificity of multidrug ABC transporters: closing in on the gaps in ABCB1 Trends in Biochemical Sciences  2010 35:36-42  DOI:10.1016/j.tibs.2009.07.009  PMID:19819701  PMCID:PMC4608440
    • Aller, S. G., Yu, J., Ward, A., Weng, Y., Chittaboina, S., Zhuo, R. P., Harrell, P. M., Trinh, Y. T., Zhang, Q. H., Urbatsch, I. L., Chang, G. Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding Science  2009 323:1718-1722  DOI:10.1126/science.1168750  PMID:19325113  PMCID:PMC2720052
    • degree-related publication Ward, A., Mulligan, S., Carragher, B., Chang, G., Milligan, R. A. Nucleotide dependent packing differences in helical crystals of the ABC transporter MsbA Journal of Structural Biology  2009 165:169-175  DOI:10.1016/j.jsb.2008.11.006  PMID:19114108  PMCID:PMC2703300
    • degree-related publication Littlefield, K. P., Ward, A. B., Chappie, J. S., Reedy, M. K., Bernstein, S. I., Milligan, R. A., Reedy, M. C. Similarities and differences between frozen-hydrated, rigor acto-S1 complexes of insect flight and chicken skeletal muscles Journal of Molecular Biology  2008 381:519-528  DOI:10.1016/j.jmb.2008.06.029  PMID:18588896  PMCID:PMC2567842
    • degree-related publication Bekyarova, T. I., Reedy, M. C., Baumann, B. A. J., Tregear, R. T., Ward, A., Krzic, U., Prince, K. M., Perz-Edwards, R. J., Reconditi, M., Gore, D., Irving, T. C., Reedy, M. K. Reverse actin sliding triggers strong myosin binding that moves tropomyosin Proceedings of the National Academy of Sciences of the United States of America  2008 105:10372-10377  DOI:10.1073/pnas.0709877105  PMID:18658238  PMCID:PMC2492518
    • degree-related publication Ward, A., Reyes, C. L., Yu, J., Roth, C. B., Chang, G. Flexibility in the ABC transporter MsbA: Alternating access with a twist Proceedings of the National Academy of Sciences of the United States of America  2007 104:19005-19010  DOI:10.1073/pnas.0709388104  PMID:18024585  PMCID:PMC2141898
    • degree-related publication Zhang, Q. H., Ma, X. Q., Ward, A., Hong, W. X., Jaakola, V. P., Stevens, R. C., Finn, M. G., Chang, G. Designing facial amphiphiles for the stabilization of integral membrane proteins Angewandte Chemie-International Edition  2007 46:7023-7025  DOI:10.1002/anie.200701556  PMID:17691085
    • degree-related publication Reyes, C. L., Ward, A., Yu, J., Chang, G. The structures of MsbA: Insight into ABC transporter-mediated multidrug efflux FEBS Letters  2006 580:1042-1048  DOI:10.1016/j.febslet.2005.11.033  PMID:16337944
    • degree-related publication Ward, A., Moody, M. F., Sheehan, B., Milligan, R. A., Carragher, B. Windex: A toolset for indexing helices Journal of Structural Biology  2003 144:172-183  DOI:10.1016/j.jsb.2003.10.008  PMID:14643220

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Teaching

teaching activities

  • Biophysics - STBIO510 Course Director

advisees

  • graduate advising relationship

    • Alkutkar, Tanwee P, Ph.D.  candidate, 2018 -
    • Cottrell, Christopher, Ph.D.  candidate, 2015 -
    • Jojoa Cruz, Sebastian, Ph.D.  candidate, 2017 -
    • Leon, Andre Nicolas, Ph.D.  candidate, 2019 -
    • Nogal, Bartek, Ph.D.  candidate, 2015 -
    • Pratap, Payal Priyanka, Ph.D.  candidate, 2019 -
    • Kefauver, Jennifer, Ph.D.  candidate, 2013 - 2018
    • Lee, Jeong Hyun, Ph.D.  candidate, 2012 - 2016
    • Murin, Charles Daniel, Ph.D.  candidate, 2012 - 2016
  • postdoc or fellow advising relationship

    • Murin, Charles Daniel, Ph.D.  candidate, 2016 -
    • Kirchdoerfer, Robert, Ph.D.  candidate, 2015 - 2019
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Background

education and training

  • Ph.D. in Biology, Scripps Research 2003 - 2008
  • B.S. in Biology, Duke University 2001

advisee of

  • graduate advising relationship

    • Chang, Geoffrey, Ph.D.  candidacy, 2004 - 2008
    • Milligan, Ronald, Ph.B.  candidacy, 2004 - 2008
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Contact

full name

  • Andrew B. Ward

geographic location

  • Scripps California 
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Identity

ORCID iD

  • ORCID iD http://orcid.org/0000-0001-7153-3769

ResearcherID (Thomson Reuters)

  • F-9203-2014

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