Ward, Andrew

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- Guthmiller, J. J., Han, J. L. N., Utset, H. A., Li, L., Lan, Ldyl, Henry, C., Stamper, C. T., McMahon, M., O'Dell, G., Fernandez-Quintero, M. L., Freyn, A. W., Amanat, F., et al. Broadly neutralizing antibodies target a haemagglutinin anchor epitope Nature 2022 DOI:10.1038/s41586-021-04356-8 PMID:34942633 PMCID:PMC8828479
- Antanasijevic, A., Bowman, C. A., Kirchdoerfer, R. N., Cottrell, C. A., Ozorowski, G., Upadhyay, A. A., Cirelli, K. M., Carnathan, D. G., Enemuo, C. A., Sewall, L. M., Nogal, B., Zhao, F., et al. From structure to sequence: Antibody discovery using cryoEM Science Advances 2022 8 DOI:10.1126/sciadv.abk2039 PMID:35044813 PMCID:PMC8769551
- van Schooten, J., van Haaren, M. M., Li, H., McCoy, L. E., Havenar-Daughton, C., Cottrell, C. A., Burger, J. A., van der Woude, P., Helgers, L. C., Tomris, I., Labranche, C. C., Montefiori, D. C., et al. Antibody responses induced by SHIV infection are more focused than those induced by soluble native HIV-1 envelope trimers in non-human primates PLoS Pathogens 2021 17 DOI:10.1371/journal.ppat.1009736 PMID:34432859 PMCID:PMC8423243
- Antanasijevic, A., Sewall, L. M., Cottrell, C. A., Carnathan, D. G., Jimenez, L. E., Ngo, J. T., Silverman, J. B., Groschel, B., Georgeson, E., Bhiman, J., Bastidas, R., LaBranche, C., et al. Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM Nature Communications 2021 12 DOI:10.1038/s41467-021-25087-4 PMID:34376662 PMCID:PMC8355326
- Turner, H. L., Andrabi, R., Cottrell, C. A., Richey, S. T., Song, G., Callaghan, S., Anzanello, F., Moyer, T. J., Abraham, W., Melo, M., Silva, M., Scaringi, N., et al. Disassembly of HIV envelope glycoprotein trimer immunogens is driven by antibodies elicited via immunization Science Advances 2021 7 DOI:10.1126/sciadv.abh2791 PMID:34321200 PMCID:PMC8318364
- Amanat, F., Strohmeier, S., Lee, W. H., Bangaru, S., Ward, A. B., Coughlan, L., Krammer, F. Murine Monoclonal Antibodies against the Receptor Binding Domain of SARS-CoV-2 Neutralize Authentic Wild-Type SARS-CoV-2 as Well as B.1.1.7 and B.1.351 Viruses and Protect In Vivo in a Mouse Model in a Neutralization-Dependent Manner mBio 2021 12 DOI:10.1128/mBio.01002-21 PMID:34311574 PMCID:PMC8406178
- Kumar, S., Lin, X., Ngo, T., Shapero, B., Sou, C., Allen, J. D., Copps, J., Zhang, L., Ozorowski, G., He, L. L., Crispin, M., Ward, A. B., et al. Neutralizing Antibodies Induced by First-Generation gp41-Stabilized HIV-1 Envelope Trimers and Nanoparticles mBio 2021 12 DOI:10.1128/mBio.00429-21 PMID:34156262 PMCID:PMC8262854
- Guthmiller, Jenna J., Han, Julianna and Li, Lei, Freyn, Alec W., Liu, Sean T. H., Stovicek, Olivia, Stamper, Christopher T., Dugan, Haley L., Tepora, Micah E., Utset, Henry A., Bitar, Dalia J., Hamel, Natalie J., Changrob, Siriruk and Zheng, Nai-Ying, et al. First exposure to the pandemic H1N1 virus induced broadly neutralizing antibodies targeting hemagglutinin head epitopes Science Translational Medicine 2021 13 DOI:10.1126/scitranslmed.abg4535 PMID:34078743
- Rossignol, Evan D., Dugast, Anne-Sophie and Compere, Hacheming, Cottrell, Christopher A., Copps, Jeffrey and Lin, Shu, Cizmeci, Deniz, Seaman, Michael S., Ackerman, Margaret E., Ward, A., Alter, Galit and Julg, Boris Mining HIV controllers for broad and functional antibodies to recognize and eliminate HIV-infected cells Cell Reports 2021 35 DOI:10.1016/j.celrep.2021.109167 PMID:34038720 PMCID:PMC8196545
- Yuan, M., Huang, D. L., Lee, C. C. D., Wu, N. C., Jackson, A. M., Zhu, X. Y., Liu, H. J., Peng, L. (141479, Van Gils, M. J., Sanders, R. W., Burton, D. R., Reincke, S. M., et al. Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants Science 2021 373:818-+ DOI:10.1126/science.abh1139 PMID:34016740 PMCID:PMC8284396
- Song, G., He, Wan-ting and Callaghan, Sean, Anzanello, Fabio and Huang, Deli, Ricketts, James, Torres, Jonathan L., Beutler, N., Peng, L., Vargas, Sirena and Cassell, Jon, Parren, Mara and Yang, Linlin, Ignacio, Caroline, Smith, Davey M., Voss, J. E., et al. Cross-reactive serum and memory B-cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infection Nature Communications 2021 12 DOI:10.1038/s41467-021-23074-3 PMID:34011939 PMCID:PMC8134462
- He, Linling and Chaudhary, Anshul, Lin, X., Sou, Cindy, Alkutkar, T., Kumar, Sonu and Ngo, Timothy, Kosviner, Ezra and Ozorowski, Gabriel, Stanfield, R. L., Ward, A. B., Wilson, I. A., Zhu, J. Single-component multilayered self-assembling nanoparticles presenting rationally designed glycoprotein trimers as Ebola virus vaccines Nature Communications 2021 12 DOI:10.1038/s41467-021-22867-w PMID:33976149 PMCID:PMC8113551
- Liu, H. J., Yuan, M., Huang, D. L., Bangaru, S., Zhao, F., Lee, C. C. D., Peng, L., Barman, S., Zhu, X. Y., Nemazee, D., Burton, D. R., van Gils, M. J., et al. A combination of cross-neutralizing antibodies synergizes to prevent SARS-CoV-2 and SARS-CoV pseudovirus infection Cell Host & Microbe 2021 29:806-818 DOI:10.1016/j.chom.2021.04.005 PMID:33894127 PMCID:PMC8049401
- Murin, C. D., Gilchuk, P., Ilinykh, P. A., Huang, K., Kuzmina, N., Shen, X. L., Bruhn, J. F., Bryan, A. L., Davidson, E., Doranz, B. J., Williamson, L. E., Copps, J., et al. Convergence of a common solution for broad ebolavirus neutralization by glycan cap-directed human antibodies Cell Reports 2021 35 DOI:10.1016/j.celrep.2021.108984 PMID:33852862 PMCID:PMC8133395
- Kumar, R., Deshpande, S., Sewall, L. M., Ozorowski, G., Cottrell, C. A., Lee, W. H., Holden, L. G., Richey, S. T., Chandrawacar, A. S., Dhiman, K., Ashish, F., Kumar, V., et al. Elicitation of potent serum neutralizing antibody responses in rabbits by immunization with an HIV-1 clade C trimeric Env derived from an Indian elite neutralizer PLoS Pathogens 2021 17 DOI:10.1371/journal.ppat.1008977 PMID:33826683 PMCID:PMC8055034
- Derking, R., Allen, J. D., Cottrell, C. A., Sliepen, K., Seabright, G. E., Lee, W. H., Aldon, Y., Rantalainen, K., Antanasijevic, A., Copps, J., Yasmeen, A., Cupo, A., et al. Enhancing glycan occupancy of soluble HIV-1 envelope trimers to mimic the native viral spike Cell Reports 2021 35 DOI:10.1016/j.celrep.2021.108933 PMID:33826885
- Lee, C. C. D., Watanabe, Y., Wu, N. C., Han, J., Kumar, S., Pholcharee, T., Seabright, G. E., Allen, J. D., Lin, C. W., Yang, J. R., Liu, M. T., Wu, C. Y., et al. A cross-neutralizing antibody between HIV-1 and influenza virus PLoS Pathogens 2021 17 DOI:10.1371/journal.ppat.1009407 PMID:33750987 PMCID:PMC8016226
- Andreano, E., Nicastri, E., Paciello, I., Pileri, P., Manganaro, N., Piccini, G., Manenti, A., Pantano, E., Kabanova, A., Troisi, M., Vacca, F., Cardamone, D., et al. Extremely potent human monoclonal antibodies from COVID-19 convalescent patients Cell 2021 184:1821-1835 DOI:10.1016/j.cell.2021.02.035 PMID:33667349 PMCID:PMC7901298
- Freyn, A. W., Han, J. L. N., Guthmiller, J. J., Bailey, M. J., Neu, K., Turner, H. L., Rosado, V. C., Chromikova, V., Huang, M., Strohmeier, S., Liu, S. T. H., Simon, V., et al. Influenza hemagglutinin-specific IgA Fc-effector functionality is restricted to stalk epitopes Proceedings of the National Academy of Sciences of the United States of America 2021 118 DOI:10.1073/pnas.2018102118 PMID:33593910 PMCID:PMC7923359
- Brouwer, P. J. M., Antanasijevic, A., de Gast, M., Allen, J. D., Bijl, T. P. L., Yasmeen, A., Ravichandran, R., Burger, J. A., Ozorowski, G., Torres, J. L., LaBranche, C., Montefiori, D. C., et al. Immunofocusing and enhancing autologous Tier-2 HIV-1 neutralization by displaying Env trimers on two-component protein nanoparticles NPJ Vaccines 2021 6 DOI:10.1038/s41541-021-00285-9 PMID:33563983 PMCID:PMC7873233
- Bouwman, K. M., Tomris, I., Turner, H. L., van der Woude, R., Shamorkina, T. M., Bosman, G. P., Rockx, B., Herfst, S., Snijder, J., Haagmans, B. L., Ward, A. B., Boons, G. J., et al. Multimerization- and glycosylation-dependent receptor binding of SARS-CoV-2 spike proteins PLoS Pathogens 2021 17 DOI:10.1371/journal.ppat.1009282 PMID:33556147 PMCID:PMC7895411
- Charles, T. P., Burton, S. L., Arunachalam, P. S., Cottrell, C. A., Sewall, L. M., Bollimpelli, V. S., Gangadhara, S., Dey, A. K., Ward, A. B., Shaw, G. M., Hunter, E., Amara, R. R., et al. The C3/465 glycan hole cluster in BG505 HIV-1 envelope is the major neutralizing target involved in preventing mucosal SHIV infection PLoS Pathogens 2021 17 DOI:10.1371/journal.ppat.1009257 PMID:33556148 PMCID:PMC7895394
- Wang, Y. M., Howell, K. A., Brannan, J., Agans, K. N., Turner, H. L., Wirchnianski, A. S., Kailasan, S., Fusco, M., Galkin, A., Chiang, C. I., Zhao, X. L., Saphire, E. O., et al. Prominent Neutralizing Antibody Response Targeting the Ebolavirus Glycoprotein Subunit Interface Elicited by Immunization Journal of Virology 2021 95 DOI:10.1128/jvi.01907-20 PMID:33536172 PMCID:PMC8103683
- Han, J., Schmitz, A. J., Richey, S. T., Dai, Y. N., Turner, H. L., Mohammed, B. M., Fremont, D. H., Ellebedy, A. H., Ward, A. B. Polyclonal epitope mapping reveals temporal dynamics and diversity of human antibody responses to H5N1 vaccination Cell Reports 2021 34 DOI:10.1016/j.celrep.2020.108682 PMID:33503432 PMCID:PMC7888560
- Brouwer, P. J. M., Brinkkemper, M., Maisonnasse, P., Dereuddre-Bosquet, N., Grobben, M., Claireaux, M., de Gast, M., Marlin, R., Chesnais, V., Diry, S., Allen, J. D., Watanabe, Y., et al. Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection Cell 2021 184:1188-1200 DOI:10.1016/j.cell.2021.01.035 PMID:33577765 PMCID:PMC7834972
- Dingens, A. S., Pratap, P., Malone, K., Hilton, S. K., Ketas, T., Cottrell, C. A., Overbaugh, J., Moore, J. P., Klasse, P. J., Ward, A. B., Bloom, J. D. High-resolution mapping of the neutralizing and binding specificities of polyclonal sera post-HIV Env trimer vaccination eLife 2021 10 DOI:10.7554/eLife.64281 PMID:33438580 PMCID:PMC7864656
- van Haaren, M. M., McCoy, L. E., Torres, J. L., Lee, W., Cottrell, C. A., Copps, J. L., van der Woude, P., Yasmeen, A., de Taeye, S. W., de la Pena, A. T., Moore, J. P., Burton, D. R., et al. Antibodies from Rabbits Immunized with HIV-1 Clade B SOSIP Trimers Can Neutralize Multiple Clade B Viruses by Destabilizing the Envelope Glycoprotein Journal of Virology 2021 95 DOI:10.1128/JVI.00094-21.2June2021 PMID:34076487 PMCID:PMC8354326
- Cho, H., Gonzales-Wartz, K. K., Huang, D. L., Yuan, M., Peterson, M., Liang, J., Beutler, N., Torres, J. L., Cong, Y., Postnikova, E., Bangaru, S., Talana, C. A., et al. Bispecific antibodies targeting distinct regions of the spike protein potently neutralize SARS-CoV-2 variants of concern Science Translational Medicine 2021 13 DOI:10.1126/scitranslmed.abj5413 PMID:34519517 PMCID:PMC8651051
- Gilchuk, I. M., Bangaru, S., Kose, N., Bombardi, R. G., Trivette, A., Li, S., Turner, H. L., Carnahan, R. H., Ward, A. B., Crowe, J. E. Human antibody recognition of H7N9 influenza virus HA following natural infection JCI Insight 2021 6 DOI:10.1172/jci.insight.152403 PMID:34437301 PMCID:PMC8525637
- Gu, M. G., Torres, J. L., Li, Y. J., Van Ry, A., Greenhouse, J., Wallace, S., Chiang, C. I., Pessaint, L., Jackson, A. M., Porto, M., Kar, S., Li, Y. X., et al. One dose of COVID-19 nanoparticle vaccine REVC-128 protects against SARS-CoV-2 challenge at two weeks post-immunization Emerging Microbes & Infections 2021 10:2016-2029 DOI:10.1080/22221751.2021.1994354 PMID:34651563 PMCID:PMC8567933
- Cottrell, C. A., Manne, K., Kong, R., Wang, S. S., Zhou, T. Q., Chuang, G. Y., Edwards, R. J., Henderson, R., Janowska, K., Kopp, M., Lin, B. C., Louder, M. K., et al. Structural basis of glycan276-dependent recognition by HIV-1 broadly neutralizing antibodies Cell Reports 2021 37 DOI:10.1016/j.celrep.2021.109922 PMID:34731616
- Kirchdoerfer, R. N., Bhandari, M., Martini, O., Sewall, L. M., Bangaru, S., Yoon, K. J., Ward, A. B. Structure and immune recognition of the porcine epidemic diarrhea virus spike protein Structure 2020 29:385-392 DOI:10.1016/j.str.2020.12.003 PMID:33378641 PMCID:PMC7962898
- Liu, H. J., Wu, N. C., Yuan, M., Bangaru, S., Torres, J. L., Caniels, T. G., van Schooten, J., Zhu, X. Y., Lee, C. C. D., Brouwer, P. J. M., van Gils, M. J., Sanders, R. W., et al. Cross-Neutralization of a SARS-CoV-2 Antibody to a Functionally Conserved Site Is Mediated by Avidity Immunity 2020 53:1272-1280 DOI:10.1016/j.immuni.2020.10.023 PMID:33242394 PMCID:PMC7687367
- Kefauver, J. M., Ward, A. B., Patapoutian, A. Discoveries in structure and physiology of mechanically activated ion channels Nature 2020 587:567-576 DOI:10.1038/s41586-020-2933-1 PMID:33239794
- Ozorowski, G., Torres, J. L., Santos-Martins, D., Forli, S., Ward, A. B. A Strain-Specific Inhibitor of Receptor-Bound HIV-1 Targets a Pocket near the Fusion Peptide Cell Reports 2020 33 DOI:10.1016/j.celrep.2020.108428 PMID:33238117 PMCID:PMC7701285
- Schorcht, Anna, van den Kerkhof, Tom L. G. M., Cottrell, C., Allen, Joel D., Torres, Jonathan L., Behrens, Anna-Janina, Schermer, Edith E., Burger, Judith A., de Taeye, Steven W., de la Pena, Alba Torrents and Bontjer, Ilja, Gumbs, Stephanie and Ozorowski, Gabriel, LaBranche, Celia C., et al. Neutralizing Antibody Responses Induced by HIV-1 Envelope Glycoprotein SOSIP Trimers Derived from Elite Neutralizers Journal of Virology 2020 94 DOI:10.1128/jvi.01214-20 PMID:32999024 PMCID:PMC7925178
- Chakraborty, S., Berndsen, Z. T., Hengartner, N. W., Korber, B. T., Ward, A. B., Gnanakaran, S. Quantification of the Resilience and Vulnerability of HIV-1 Native Glycan Shield at Atomistic Detail iScience 2020 23 DOI:10.1016/j.isci.2020.101836 PMID:33319171 PMCID:PMC7724196
- Guthmiller, J. J., Lan, Ldyl, Fernandez-Quintero, M. L., Han, J., Utset, H. A., Bitar, D. J., Hamel, N. J., Stovicek, O., Li, L., Tepora, M., Henry, C., Neu, K. E., et al. Polyreactive Broadly Neutralizing B cells Are Selected to Provide Defense against Pandemic Threat Influenza Viruses Immunity 2020 53:1230-1244 DOI:10.1016/j.immuni.2020.10.005 PMID:33096040 PMCID:PMC7772752
- Berndsen, Z. T., Chakraborty, S., Wang, X. N., Cottrell, C. A., Torres, J. L., Diedrich, J. K., Lopez, C. A., Yates III, J. R., van Gils, M. J., Paulson, J. C., Gnanakaran, S., Ward, A. B. Visualization of the HIV-1 Env glycan shield across scales Proceedings of the National Academy of Sciences of the United States of America 2020 117:28014-28025 DOI:10.1073/pnas.2000260117 PMID:33093196 PMCID:PMC7668054
- Bangaru, S., Ozorowski, G., Turner, H. L., Antanasijevic, A., Huang, D. L., Wang, X. N., Torres, J. L., Diedrich, J. K., Tian, J. H., Portnoff, A. D., Patel, N., Massare, M. J., et al. Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate Science 2020 370:1089-1094 DOI:10.1126/science.abe1502 PMID:33082295 PMCID:PMC7857404
- Wu, N. C., Yuan, M., Liu, H., Lee, C. C. D., Zhu, X., Bangaru, S., Torres, J. L., Caniels, T. G., Brouwer, P. J. M., van Gils, M. J., Sanders, R. W., Ward, A. B., et al. An Alternative Binding Mode of IGHV3-53 Antibodies to the SARS-CoV-2 Receptor Binding Domain Cell Reports 2020 33 DOI:10.1016/j.celrep.2020.108274 PMID:33027617 PMCID:PMC7522650
- Clausen, T. M., Sandoval, D. R., Spliid, C. B., Pihl, J., Perrett, H. R., Painter, C. D., Narayanan, A., Majowicz, S. A., Kwong, E. M., McVicar, R. N., Thacker, B. E., Glass, C. A., et al. SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2 Cell 2020 183:1043-1057 DOI:10.1016/j.cell.2020.09.033 PMID:32970989 PMCID:PMC7489987
- Zhao, F., Joyce, C., Burns, A., Nogal, B., Cottrell, C. A., Ramos, A., Biddle, T., Pauthner, M., Nedellec, R., Qureshi, H., Mason, R., Landais, E., et al. Mapping Neutralizing Antibody Epitope Specificities to an HIV Env Trimer in Immunized and in Infected Rhesus Macaques Cell Reports 2020 32 DOI:10.1016/j.celrep.2020.108122 PMID:32905766 PMCID:PMC7487785
- Dong, J. H., Gilchuk, I., Li, S., Irving, R., Goff, M. T., Turner, H. L., Ward, A. B., Carnahan, R. H., Crowe, J. E. Anti-influenza H7 human antibody targets antigenic site in hemagglutinin head domain interface Journal of Clinical Investigation 2020 130:4734-4739 DOI:10.1172/jci136032 PMID:32749241 PMCID:PMC7456233
- van der Woude, R., Turner, H. L., Tomris, I., Bouwman, K. M., Ward, A. B., de Vries, R. P. Drivers of recombinant soluble influenza A virus hemagglutinin and neuraminidase expression in mammalian cells Protein Science 2020 29:1975-1982 DOI:10.1002/pro.3918 PMID:32710576 PMCID:PMC7454420
- Turner, J. S., Zhou, J. Q., Han, J., Schmitz, A. J., Rizk, A. A., Alsoussi, W. B., Lei, T. T., Amor, M., McIntire, K. M., Meade, P., Strohmeier, S., Brent, R. I., et al. Human germinal centres engage memory and naive B cells after influenza vaccination Nature 2020 586:127-132 DOI:10.1038/s41586-020-2711-0 PMID:32866963
- Cottrell, C. A., van Schooten, J., Bowman, C. A., Yuan, M., Oyen, D., Shin, M., Morpurgo, R., van der Woude, P., van Breemen, M., Torres, J. L., Patel, R., Gross, J., et al. Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates PLoS Pathogens 2020 16 DOI:10.1371/journal.ppat.1008753 PMID:32866207 PMCID:PMC7485981
- Antanasijevic, A., Ueda, G., Brouwer, P. J. M., Copps, J., Huang, D. L., Allen, J. D., Cottrell, C. A., Yasmeen, A., Sewall, L. M., Bontjer, I., Ketas, T. J., Turner, H. L., et al. Structural and functional evaluation ofde novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens PLoS Pathogens 2020 16 DOI:10.1371/journal.ppat.1008665 PMID:32780770 PMCID:PMC7418955
- Brouwer, P. J. M., Caniels, T. G., van der Straten, K., Snitselaar, J. L., Aldon, Y., Bangaru, S., Torres, J. L., Okba, N. M. A., Claireaux, M., Kerster, G., Bentlage, A. E. H., van Haaren, M. M., et al. Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability Science 2020 369:643-650 DOI:10.1126/science.abc5902 PMID:32540902 PMCID:PMC7299281
- Martin, J. T., Cottrell, C. A., Antanasijevic, A., Carnathan, D. G., Cossette, B. J., Enemuo, C. A., Gebru, E. H., Choe, Y., Viviano, F., Fischinger, S., Tokatlian, T., Cirelli, K. M., et al. Targeting HIV Env immunogens to B cell follicles in nonhuman primates through immune complex or protein nanoparticle formulations NPJ Vaccines 2020 5 DOI:10.1038/s41541-020-00223-1 PMID:32802411 PMCID:PMC7406516
- Seabright, G. E., Cottrell, C. A., van Gils, M. J., D'Addabbo, A., Harvey, D. J., Behrens, A. J., Allen, J. D., Watanabe, Y., Scaringi, N., Polveroni, T. M., Maker, A., Vasiljevic, S., et al. Networks of HIV-1 Envelope Glycans Maintain Antibody Epitopes in the Face of Glycan Additions and Deletions Structure 2020 28:897-906 DOI:10.1016/j.str.2020.04.022 PMID:32433992 PMCID:PMC7416112
- Ueda, G., Antanasijevic, A., Fallas, J. A., Sheffler, W., Copps, J., Ellis, D., Hutchinson, G. B., Moyer, A., Yasmeen, A., Tsybovsky, Y., Park, Y. J., Bick, M. J., et al. Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens eLife 2020 9 DOI:10.7554/eLife.57659 PMID:32748788 PMCID:PMC7402677
- Ellebedy, A. H., Nachbagauer, R., Jackson, K. J. L., Dai, Y. N., Han, J., Alsoussi, W. B., Davis, C. W., Stadlbauer, D., Rouphael, N., Chromikova, V., McCausland, M., Chang, C. Y., et al. Adjuvanted H5N1 influenza vaccine enhances both cross-reactive memory B cell and strain-specific naive B cell responses in humans Proceedings of the National Academy of Sciences of the United States of America 2020 117:17957-17964 DOI:10.1073/pnas.1906613117 PMID:32661157 PMCID:PMC7395544
- Thrane, S., Aves, K. L., Uddback, I. E. M., Janitzek, C. M., Han, J., Yang, Y. R., Ward, A. B., Theander, T. G., Nielsen, M. A., Salanti, A., Thomsen, A. R., Christensen, J. P., et al. A Vaccine Displaying a Trimeric Influenza-A HA Stem Protein on Capsid-Like Particles Elicits Potent and Long-Lasting Protection in Mice Vaccines 2020 8 DOI:10.3390/vaccines8030389 PMID:32679905 PMCID:PMC7564254
- Carnathan, D. G., Kaushik, K., Ellebedy, A. H., Enemuo, C. A., Gebru, E. H., Dhadvai, P., Rasheed, M. A. U., Pauthner, M. G., Ozorowski, G., Ahmed, R., Burton, D. R., Ward, A. B., et al. Harnessing Activin A Adjuvanticity to Promote Antibody Responses to BG505 HIV Envelope Trimers Frontiers in Immunology 2020 11 DOI:10.3389/fimmu.2020.01213 PMID:32612608 PMCID:PMC7308430
- Nogal, B., McCoy, L. E., van Gils, M. J., Cottrell, C. A., Voss, J. E., Andrabi, R., Pauthner, M., Liang, C. H., Messmer, T., Nedellec, R., Shin, M., Turner, H. L., et al. HIV envelope trimer-elicited autologous neutralizing antibodies bind a region overlapping the N332 glycan supersite Science Advances 2020 6 DOI:10.1126/sciadv.aba0512 PMID:32548265 PMCID:PMC7274786
- Rantalainen, K., Berndsen, Z. T., Antanasijevic, A., Schiffner, T., Zhang, X., Lee, W. H., Torres, J. L., Zhang, L., Irimia, A., Copps, J., Zhou, K. H., Kwon, Y. D., et al. HIV-1 Envelope and MPER Antibody Structures in Lipid Assemblies Cell Reports 2020 31 DOI:10.1016/j.celrep.2020.107583 PMID:32348769 PMCID:PMC7196886
- Ward, A. B., Wilson, I. A. Innovations in structure-based antigen design and immune monitoring for next generation vaccines Current Opinion in Immunology 2020 65:50-56 DOI:10.1016/j.coi.2020.03.013 PMID:32387642 PMCID:PMC7174181
- Yang, Y. H. R., McCoy, L. E., van Gils, M. J., Andrabi, R., Turner, H. L., Yuan, M., Cottrell, C. A., Ozorowski, G., Voss, J., Pauthner, M., Polveroni, T. M., Messmer, T., et al. Autologous antibody responses to an HIV envelope glycan hole are not easily broadened in rabbits Journal of Virology 2020 94 DOI:10.1128/jvi.01861-19 PMID:31941772 PMCID:PMC7081899
- Ringe, R. P., Portillo, V. M. C., Dosenovic, P., Ketas, T. J., Ozorowski, G., Nogal, B., Perez, L., LaBranche, C. C., Lim, J., Francomano, E., Wilson, I. A., Sanders, R. W., et al. Neutralizing antibody induction by HIV-1 envelope glycoprotein SOSIP trimers on iron oxide nanoparticles may be impaired by mannose binding lectin Journal of Virology 2020 94 DOI:10.1128/jvi.01883-19 PMID:31852794
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- Fisher, L. S., Ward, A., Milligan, R. A., Unwin, N., Potter, C. S., Carragher, B. A helical processing pipeline for EM structure determination of membrane proteins Methods 2011 55:350-362 DOI:10.1016/j.ymeth.2011.09.013 PMID:21964395 PMCID:PMC3262078
- Pejchal, R., Doores, K. J., Walker, L. M., Khayat, R., Huang, P. S., Wang, S. K., Stanfield, R. L., Julien, J. P., Ramos, A., Crispin, M., Depetris, R., Katpally, U., et al. A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield Science 2011 334:1097-1103 DOI:10.1126/science.1213256 PMID:21998254 PMCID:PMC3280215
- Bai, J. P., Swartz, D. J., Protasevich, II, Brouillette, C. G., Harrell, P. M., Hildebrandt, E., Gasser, B., Mattanovich, D., Ward, A., Chang, G., Urbatsch, I. L. A gene optimization strategy that enhances production of fully functional p-glycoprotein in pichia pastoris PLoS One 2011 6:e22577 DOI:10.1371/journal.pone.0022577 PMID:21826197 PMCID:PMC3149604
- Perz-Edwards, R. J., Irving, T. C., Baumann, B. A. J., Gore, D., Hutchinson, D. C., Krzic, U., Porter, R. L., Ward, A. B., Reedy, M. K. X-ray diffraction evidence for myosin-troponin connections and tropomyosin movement during stretch activation of insect flight muscle Proceedings of the National Academy of Sciences of the United States of America 2011 108:120-125 DOI:10.1073/pnas.1014599107 PMID:21148419 PMCID:PMC3017141
- Glaves, J. P., Fisher, L., Ward, A., Young, H. S. Helical crystallization of two example membrane proteins MsbA and the Ca(2+)-ATPase Methods in Enzymology 2010 483:143-159 DOI:10.1016/s0076-6879(10)83007-1 PMID:20888473
- Gutmann, D. A. P., Ward, A., Urbatsch, I. L., Chang, G., van Veen, H. W. Understanding polyspecificity of multidrug ABC transporters: closing in on the gaps in ABCB1 Trends in Biochemical Sciences 2010 35:36-42 DOI:10.1016/j.tibs.2009.07.009 PMID:19819701 PMCID:PMC4608440
- Aller, S. G., Yu, J., Ward, A., Weng, Y., Chittaboina, S., Zhuo, R. P., Harrell, P. M., Trinh, Y. T., Zhang, Q. H., Urbatsch, I. L., Chang, G. Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding Science 2009 323:1718-1722 DOI:10.1126/science.1168750 PMID:19325113 PMCID:PMC2720052
- Ward, A., Mulligan, S., Carragher, B., Chang, G., Milligan, R. A. Nucleotide dependent packing differences in helical crystals of the ABC transporter MsbA Journal of Structural Biology 2009 165:169-175 DOI:10.1016/j.jsb.2008.11.006 PMID:19114108 PMCID:PMC2703300
- Littlefield, K. P., Ward, A. B., Chappie, J. S., Reedy, M. K., Bernstein, S. I., Milligan, R. A., Reedy, M. C. Similarities and differences between frozen-hydrated, rigor acto-S1 complexes of insect flight and chicken skeletal muscles Journal of Molecular Biology 2008 381:519-528 DOI:10.1016/j.jmb.2008.06.029 PMID:18588896 PMCID:PMC2567842
- Bekyarova, T. I., Reedy, M. C., Baumann, B. A. J., Tregear, R. T., Ward, A., Krzic, U., Prince, K. M., Perz-Edwards, R. J., Reconditi, M., Gore, D., Irving, T. C., Reedy, M. K. Reverse actin sliding triggers strong myosin binding that moves tropomyosin Proceedings of the National Academy of Sciences of the United States of America 2008 105:10372-10377 DOI:10.1073/pnas.0709877105 PMID:18658238 PMCID:PMC2492518
- Ward, A., Reyes, C. L., Yu, J., Roth, C. B., Chang, G. Flexibility in the ABC transporter MsbA: Alternating access with a twist Proceedings of the National Academy of Sciences of the United States of America 2007 104:19005-19010 DOI:10.1073/pnas.0709388104 PMID:18024585 PMCID:PMC2141898
- Zhang, Q. H., Ma, X. Q., Ward, A., Hong, W. X., Jaakola, V. P., Stevens, R. C., Finn, M. G., Chang, G. Designing facial amphiphiles for the stabilization of integral membrane proteins Angewandte Chemie-International Edition 2007 46:7023-7025 DOI:10.1002/anie.200701556 PMID:17691085
- Reyes, C. L., Ward, A., Yu, J., Chang, G. The structures of MsbA: Insight into ABC transporter-mediated multidrug efflux FEBS Letters 2006 580:1042-1048 DOI:10.1016/j.febslet.2005.11.033 PMID:16337944
- Ward, A., Moody, M. F., Sheehan, B., Milligan, R. A., Carragher, B. Windex: A toolset for indexing helices Journal of Structural Biology 2003 144:172-183 DOI:10.1016/j.jsb.2003.10.008 PMID:14643220

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