recent publications
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academic article
- Mediouni, S., Chinthalapudi, K., Ekka, M. K., Usui, I., Jablonski, J. A., Clementz, M. A., Mousseau, G., Nowak, J., Macherla, V. R., Beverage, J. N., Esquenazi, E., Baran, P., et al. Didehydro-cortistatin A inhibits HIV-1 by specifically binding to the unstructured basic region of Tat MBio 2019 10:e02662-18 DOI:10.1128/mBio.02662-18 PMID:30723126 PMCID:PMC6368365
- Takata, H., Kessing, C., Sy, A., Lima, N., Sciumbata, J., Mori, L., Jones, R. B., Chomont, N., Michael, N. L., Valente, S., Trautmann, L. Modeling HIV-1 latency using primary CD4(+) T cells from virally suppressed HIV-1-infected individuals on antiretroviral therapy Journal of Virology 2019 93:e02248-18 DOI:10.1128/jvi.02248-18 PMID:30918072
- Mousseau, G., Aneja, R., Clementz, M. A., Mediouni, S., Lima, N. S., Haregot, A., Kessing, C. F., Jablonski, J. A., Thenin-Houssier, S., Nagarsheth, N., Trautmann, L., Valente, S. T. Resistance to the Tat inhibitor didehydro-cortistatin a is mediated by heightened basal HIV-1 transcription MBio 2019 10:e01750-18 DOI:10.1128/mBio.01750-18 PMID:31266880 PMCID:PMC6606815
- Li, C., Mousseau, G., Valente, S. T. Tat inhibition by didehydro-Cortistatin A promotes heterochromatin formation at the HIV-1 long terminal repeat Epigenetics & Chromatin 2019 12 DOI:10.1186/s13072-019-0267-8 PMID:30992052 PMCID:PMC6466689
- Mediouni, S., Kessing, C. F., Jablonski, J. A., Thenin-Houssier, S., Clementz, M., Kovach, M. D., Mousseau, G., de Vera, I. M. S., Li, C., Kojetin, D. J., Evans, D. T., Valente, S. T. The Tat inhibitor didehydro-cortistatin A suppresses SIV replication and reactivation FASEB Journal 2019 33:8280-8293 DOI:10.1096/fj.201801165R PMID:31021670 PMCID:PMC6593873
- Mediouni, S., Jablonski, J. A., Tsuda, S., Richard, A., Kessing, C., Andrade, M. V., Biswas, A., Even, Y., Tellinghuisen, T., Choe, H., Cameron, M., Stevenson, M., et al. Potent suppression of HIV-1 cell attachment by Kudzu root extract Retrovirology 2018 15 DOI:10.1186/s12977-018-0446-x PMID:30236131 PMCID:PMC6149077
- Kessing, C. F., Nixon, C. C., Li, C., Tsai, P., Takata, H., Mousseau, G., Ho, P. T., Honeycutt, J. B., Fallahi, M., Trautmann, L., Garcia, J. V., Valente, S. T. In vivo suppression of HIV rebound by didehydro-Cortistatin A, a "block-and-lock'' strategy for HIV-1 treatment Cell Reports 2017 21:600-611 DOI:10.1016/j.celrep.2017.09.080 PMID:29045830 PMCID:PMC5653276
- Mousseau, G., Valente, S. T. Role of host factors on the regulation of Tat-mediated HIV-1 transcription Current Pharmaceutical Design 2017 23:4079-4090 DOI:10.2174/1381612823666170622104355 PMID:28641539
- Wu, H., Mousseau, G., Mediouni, S., Valente, S. T., Kodadek, T. Cell-permeable peptides containing cycloalanine residues Angewandte Chemie-International Edition 2016 55:12637-12642 DOI:10.1002/anie.201605745 PMID:27529332
- Mousseau, G., Valente, S. T. Didehydro-Cortistatin A: a new player in HIV-therapy? Expert Review of Anti-Infective Therapy 2016 14:145-148 DOI:10.1586/14787210.2016.1122525 PMID:26581953 PMCID:PMC4793404
- Thenin-Houssier, S., de Vera, I. M. S., Pedro-Rosa, L., Brady, A., Richard, A., Konnick, B., Opp, S., Buffone, C., Fuhrmann, J., Kota, S., Billack, B., Pietka-Ottlik, M., et al. Ebselen, a small-molecule capsid inhibitor of HIV-1 replication Antimicrobial Agents and Chemotherapy 2016 60:2195-2208 DOI:10.1128/aac.02574-15 PMID:26810656 PMCID:PMC4808204
- Thenin-Houssier, S., Valente, S. T. HIV-1 capsid inhibitors as antiretroviral agents Current HIV Research 2016 14:270-282 DOI:10.2174/1570162x14999160224103555 PMID:26957201 PMCID:PMC4785820
- Deeks, S. G., Lewin, S. R., Ross, A. L., Ananworanich, J., Benkirane, M., Cannon, P., Chomont, N., Douek, D., Lifson, J. D., Lo, Y. R., Kuritzkes, D., Margolis, D., et al. International AIDS Society global scientific strategy: towards an HIV cure 2016 Nature Medicine 2016 22:839-850 DOI:10.1038/nm.4108 PMID:27400264
- Mediouni, S., Jablonski, J., Paris, J. J., Clementz, M. A., Thenin-Houssier, S., McLaughlin, J. P., Valente, S. T. Didehydro-cortistatin A inhibits HIV-1 Tat mediated neuroinflammation and prevents potentiation of cocaine reward in Tat transgenic mice Current HIV Research 2015 13:64-79 DOI:10.2174/1570162x13666150121111548 PMID:25613133 PMCID:PMC4416414
- Mousseau, G., Kessing, C., Fromentin, R., Trautmann, L., Chomont, N., Valente, S. T. The Tat inhibitor didehydro-Cortistatin A prevents HIV-1 reactivation from latency MBio 2015 3:e00465 DOI:10.1128/mBio.00465-15 PMID:26152583 PMCID:PMC4495168
- Mousseau, G., Kessing, C. F., Fromentin, R., Trautmann, L., Chomont, N., Valente, S. T. The Tat inhibitor didehydro-cortistatin a prevents HIV-1 reactivation from latency MBio 2015 6:e00465-15 DOI:10.1128/mBio.00465-15 PMID:26152583 PMCID:PMC4495168
- Mediouni, S., Marcondes, M. C. G., Miller, C., McLaughlin, J. P., Valente, S. T. The cross-talk of HIV-1 Tat and methamphetamine in HIV-associated neurocognitive disorders Frontiers in Microbiology 2015 6:1164 DOI:10.3389/fmicb.2015.01164 PMID:26557111 PMCID:PMC4615951
- Jablonski, J., Clementz, M., Ryan, K., Valente, S. T. Analysis of RNA processing reactions using cell free systems: 3' end cleavage of pre-mRNA substrates in vitro Journal of Visualized Experiments : JoVE 2014 e51309 DOI:10.3791/51309 PMID:24835792 PMCID:PMC4030693
- Mousseau, G., Clementz, M. A., Bakeman, W. N., Nagarsheth, N., Cameron, M., Shi, J., Baran, P., Fromentin, R., Chomont, N., Valente, S. T. An analog of the natural steroidal alkaloid cortistatin A potently suppresses Tat-dependent HIV transcription Cell Host & Microbe 2012 12:97-108 DOI:10.1016/j.chom.2012.05.016 PMID:22817991 PMCID:PMC3403716
- Mousseau, G., Valente, S. Strategies to block HIV transcription: Focus on small molecule Tat inhibitors Biology 2012 1:668-697 DOI:doi:10.3390/biology1030668 PMID:24832514 PMCID:PMC4009808
- Valente, S. T., Gilmartin, G. M., Venkatarama, K., Arriagada, G., Goff, S. P. HIV-1 mRNA 3' end processing is distinctively regulated by elF3f, CDK11, and splice factor 9G8 Molecular Cell 2009 36:279-289 DOI:10.1016/j.molcel.2009.10.004 PMID:19854136 PMCID:PMC3068534
- Valente, S. T., Gilmartin, G. M., Mott, C., Falkard, B., Goff, S. P. Inhibition of HIV-1 replication by elF3f Proceedings of the National Academy of Sciences of the United States of America 2009 106:4071-4078 DOI:10.1073/pnas.0900557106 PMID:19237569 PMCID:PMC2646627
- Valente, S. T., Goff, S. P. Somatic cell genetic analyses to identify HIV-1 host restriction factors Methods in Molecular Biology 2009 485:235-255 DOI:10.1007/978-1-59745-170-3_17 PMID:19020830 PMCID:PMC3804074
- Naghavi, M. H., Valente, S., Hatziioannou, T., de los Santos, K., Wen, Y., Mott, C., Gundersen, G. G., Goff, S. P. Moesin regulates stable microtubule formation and limits retroviral infection in cultured cells EMBO Journal 2007 26:41-52 DOI:10.1038/sj.emboj.7601475 PMID:17170707 PMCID:PMC1782362
- Valente, S. T., Goff, S. P. Inhibition of HIV-1 gene expression by a fragment of hnRNP U Molecular Cell 2006 23:597-605 DOI:10.1016/j.molcel.2006.07.021 PMID:16916646
- Hazan, U., Romero, I. A., Cancello, R., Valente, S., Perrin, V., Mariot, V., Dumonceaux, J., Gerhardt, C. C., Strosberg, A. D., Couraud, P. O., Pietri-Rouxel, F. Human adipose cells express CD4, CXCR4, and CCR5 receptors: a new target cell type for the immunodeficiency virus-1 FASEB Journal 2002 16:1254-1256 DOI:10.1096/fj.01-0947fje PMID:12153994
- Valente, S. T., Chanel, C., Dumonceaux, J., Olivier, R., Marullo, S., Briand, P., Hazan, U. CXCR4 is down-regulated in cells infected with the CD4-independent X4 human immunodeficiency virus type 1 isolate m7NDK Journal of Virology 2001 75:439-447 DOI:10.1128/jvi.75.1.439-447.2001 PMID:11119612 PMCID:PMC113936
- Dumonceaux, J., Chanel, C., Valente, S., Quivet, L., Briand, P., Hazan, U. Mutations in the env gene of human immunodeficiency virus type 1 NDK isolates and the use of African green monkey CXCR4 as a co-receptor in COS-7 cells Journal of General Virology 1999 80:1975-1982 PMID:10466793
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chapter
- Mousseau, G., Mediouni, S., Valente, S. T. Targeting HIV transcription: the quest for a functional cure Future of HIV-1 therapeutics: resistance is futile?. 121-145. 2015 DOI:10.1007/82_2015_435 PMID:25731772 PMCID:PMC4409574