recent publications
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academic article
- Wilkinson, O. J., Latypov, V., Tubbs, J. L., Millington, C. L., Morita, R., Blackburn, H., Marriott, A., McGown, G., Thorncroft, M., Watson, A. J., Connolly, B. A., Grasby, J. A., et al. Alkyltransferase-like protein (atl1) distinguishes alkylated guanines for DNA repair using cation-pi interactions Proceedings of the National Academy of Sciences of the United States of America 2012 109:18755-18760 DOI:10.1073/pnas.1209451109 PMID:23112169 PMCID:PMC3503161
- Latypov, V. F., Tubbs, J. L., Watson, A. J., Marriott, A. S., McGown, G., Thorncroft, M., Wilkinson, O. J., Senthong, P., Butt, A., Arvai, A. S., Millington, C. L., Povey, A. C., et al. Atl1 regulates choice between global genome and transcription-coupled repair of o-6-alkylguanines Molecular Cell 2012 47:50-60 DOI:10.1016/j.molcel.2012.04.028 PMID:22658721 PMCID:PMC3398191
- Tubbs, J. L., Tainer, J. A. P53 conformational switching for selectivity may reveal a general solution for specific DNA binding EMBO Journal 2011 30:2099-2100 DOI:10.1038/emboj.2011.133 PMID:21629273 PMCID:PMC3117650
- Tubbs, J. L., Tainer, J. A. Alkyltransferase-like proteins: Molecular switches between DNA repair pathways Cellular and Molecular Life Sciences 2010 67:3749-3762 DOI:10.1007/s00018-010-0405-8 PMID:20502938 PMCID:PMC3088651
- Fang, Q. M., Kanugula, S., Tubbs, J. L., Tainer, J. A., Pegg, A. E. Repair of o(4)-alkylthymine by o(6)-alkylguanine-DNA alkyltransferases Journal of Biological Chemistry 2010 285:8185-8195 DOI:10.1074/jbc.M109.045518 PMID:20026607 PMCID:PMC2832970
- Aramini, J. M., Tubbs, J. L., Kanugula, S., Rossi, P., Ertekin, A., Maglaqui, M., Hamilton, K., Ciccosanti, C. T., Jiang, M., Xiao, R., Soong, T. T., Rost, B., et al. Structural basis of o(6)-alkylguanine recognition by a bacterial alkyltransferase-like DNA repair protein Journal of Biological Chemistry 2010 285:13736-13741 DOI:10.1074/jbc.M109.093591 PMID:20212037 PMCID:PMC2859536
- Tubbs, J. L., Latypov, V., Kanugula, S., Butt, A., Melikishvili, M., Kraehenbuehl, R., Fleck, O., Marriott, A., Watson, A. J., Verbeek, B., McGown, G., Thorncroft, M., et al. Flipping of alkylated DNA damage bridges base and nucleotide excision repair Nature 2009 459:808-813 DOI:10.1038/nature08076 PMID:19516334 PMCID:PMC2729916
- Fang, Q. M., Noronha, A. M., Murphy, S. P., Wilds, C. J., Tubbs, J. L., Tainer, J. A., Chowdhury, G., Guengerich, F. P., Pegg, A. E. Repair of o(6)-g-alkyl-o(6)-g interstrand cross-links by human o(6)-alkylguanine-DNA alkyltransferase Biochemistry 2008 47:10892-10903 DOI:10.1021/bi8008664 PMID:18803403 PMCID:PMC2632579
- Tubbs, J. L., Pegg, A. E., Tainer, J. A. DNA binding, nucleotide flipping, and the helix-turn-helix motif in base repair by o-6-alkylguanine-DNA alkyltransferase and its implications for cancer chemotherapy DNA Repair 2007 6:1100-1115 DOI:10.1016/j.dnarep.2007.03.011 PMID:17485252 PMCID:PMC1993358
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Tubbs, J. L., Tainer, J. A., Getzoff, E. D.
Crystallographic structures of Discosoma red fluorescent protein with immature and mature chromophores: Linking peptide bond trans-cis isomerization and acylimine formation in chromophore maturation
Biochemistry
2005
44:9833-9840
DOI:10.1021/bi0472907
PMID:16026155
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chapter
- Tubbs, J. L. DNA damage: alkylation Encyclopedia of biological chemistry. 9-15. 2013