Tse, Winston

Graduate Student

Positions

2019 - Senior Director, Vir Biotechnology
2003 - 2018 Senior Scientist, Gilead Sciences

Websites

Doctoral Dissertation

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academic article
- Yant, S. R., Mulato, A., Hansen, D., Tse, W. C., Niedziela-Majka, A., Zhang, J. R., Stepan, G. J., Jin, D., Wong, M. H., Perreira, J. M., Singer, E., Papalia, G. A., et al. A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model Nature Medicine 2019 25:1377-1384 DOI:10.1038/s41591-019-0560-x PMID:31501601
- Lad, L., Clancy, S., Koditek, D., Wong, M. H., Jin, D. B., Niedziela-Majka, A., Papalia, G. A., Hung, M., Yant, S., Somoza, J. R., Hu, E., Chou, C., et al. Functional label-free assays for characterizing the in vitro mechanism of action of small molecule modulators of capsid assembly Biochemistry 2015 54:2240-2248 DOI:10.1021/acs.biochem.5b00151 PMID:25774576
- Shih, I. H., Vliegen, I., Peng, B., Yang, H., Hebner, C., Paeshuyse, J., Purstinger, G., Fenaux, M., Tian, Y., Mabery, E., Qi, X., Bahador, G., et al. Mechanistic characterization of GS-9190 (Tegobuvir), a novel nonnucleoside inhibitor of hepatitis C virus NS5B polymerase Antimicrobial Agents and Chemotherapy 2011 55:4196-4203 DOI:10.1128/aac.00307-11 PMID:21746939 PMCID:PMC3165336
- Tse, W. C., Boger, D. L. A fluorescent intercalator displacement assay for establishing DNA binding selectivity and affinity Accounts of Chemical Research 2004 37:61-69 DOI:10.1021/ar030113y PMID:14730995
- Tse, W. C., Boger, D. L. Sequence-selective DNA recognition: natural products and nature's lessons Chemistry & Biology 2004 11:1607-1617 DOI:10.1016/j.chembiol.2003.08.012 PMID:15610844
- Tse, W. C., Ishii, T., Boger, D. L. Comprehensive high-resolution analysis of hairpin polyamides utilizing a fluorescent intercalator displacement (FID) assay Bioorganic & Medicinal Chemistry 2003 11:4479-4486 DOI:10.1016/s0968-0896(03)00455-3 PMID:13129584
- Yeung, B. K. S., Tse, W. C., Boger, D. L. Determination of binding affinities of triplex forming oligonucleotides using a fluorescent intercalator displacement (FID) assay Bioorganic & Medicinal Chemistry Letters 2003 13:3801-3804 DOI:10.1016/j.bmcl.2003.07.005 PMID:14552783
- Ham, Y. W., Tse, W. C., Boger, D. L. High-resolution assessment of protein DNA binding affinity and selectivity utilizing a fluorescent intercalator displacement (FID) assay Bioorganic & Medicinal Chemistry Letters 2003 13:3805-3807 DOI:10.1016/j.bmcl.2003.06.002 PMID:14552784
- Boger, D. L., Fink, B. E., Brunette, S. R., Tse, W. C., Hedrick, M. P. A simple, high-resolution method for establishing DNA binding affinity and sequence selectivity Journal of the American Chemical Society 2001 123:5878-5891 DOI:10.1021/ja010041a PMID:11414820
- Boger, D. L.*, Tse, W. C.* Thiazole orange as the fluorescent intercalator in a high resolution fid assay for determining DNA binding affinity and sequence selectivity of small molecules Bioorganic & Medicinal Chemistry 2001 9:2511-2518 DOI:10.1016/s0968-0896(01)00243-7 PMID:11553493 (* = equal contribution)
- Boger, D. L., Ichikawa, S., Tse, W. C., Hedrick, M. P., Jin, Q. Total syntheses of thiocoraline and be-22179 and assessment of their DNA binding and biological properties Journal of the American Chemical Society 2001 123:561-568 DOI:10.1021/ja003602r PMID:11456568
- Boger, D. L., Searcey, M., Tse, W. C., Jin, Q. Bifunctional alkylating agents derived from duocarmycin SA: Potent antitumor activity with altered sequence selectivity Bioorganic & Medicinal Chemistry Letters 2000 10:495-498 DOI:10.1016/s0960-894x(00)00042-1 PMID:10743956
- Boger, D. L., Aquila, B. M., Tse, W. C., Searcey, M. Synthesis and evaluation of a novel bleomycin A(2) analogue: Continuing assessment of the linker domain Tetrahedron Letters 2000 41:9493-9498 DOI:10.1016/s0040-4039(00)01633-6
- Lambert, J. B., Zhao, Y., Wu, H., Tse, W. C., Kuhlmann, B. The allyl leaving group approach to tricoordinate silyl, germyl, and stannyl cations Journal of the American Chemical Society 1999 121:5001-5008 DOI:10.1021/ja990389u
- Lambert, J. B., Stern, C. L., Zhao, Y., Tse, W. C., Shawl, C. E., Lentz, K. T., Kania, L. Torsional distortions in trimesitylsilanes and trimesitylgermanes Journal of Organometallic Chemistry 1998 568:21-31 DOI:10.1016/s0022-328x(98)00754-2