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Tomchik, Seth
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Tomchik, Seth

Faculty Member
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Positions

  • 2018 - Associate Professor, Neuroscience , Scripps Research
  • 2012 - Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
  • 2012 - 2018 Assistant Professor, Neuroscience , Scripps Research
  • 2009 - 2012 Senior Research Associate with Dr. Ronald L. Davis, Neuroscience , Scripps Research
  • 2007 - 2009 W.M. Keck Center BMDTP Fellow with Dr. Ronald L. Davis, Baylor College of Medicine
  • 2006 - 2007 Postdoctoral Fellow with Dr. Stephen D. Roper, Miller School of Medicine, University of Miami

Contact

  • stomchik@scripps.edu

Websites

  • Seth Tomchik, Ph.D.
  • Laboratory Website
  • Publications
  • Research
  • Teaching
  • Background
  • Contact
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Publications

recent publications
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  • academic article

    • King, L. B., Boto, T., Botero, V., Aviles, A. M., Jomsky, B. M., Joseph, C., Walker, J. A., Tomchik, S. M. Developmental loss of neurofibromin across distributed neuronal circuits drives excessive grooming inDrosophila PLoS Genetics  2020 16  DOI:10.1371/journal.pgen.1008920  PMID:32697780  PMCID:PMC7398555
    • Boto, T., Stahl, A., Tomchik, S. M. Cellular and circuit mechanisms of olfactory associative learning in Drosophila Journal of Neurogenetics  2020 34:36-46  DOI:10.1080/01677063.2020.1715971  PMID:32043414  PMCID:PMC7147969
    • Boto, T., Stahl, A., Zhang, X., Louis, T., Tomchik, S. M. Independent contributions of discrete dopaminergic circuits to cellular plasticity, memory strength, and valence in Drosophila Cell Reports  2019 27:2014-2021  DOI:10.1016/j.celrep.2019.04.069  PMID:31091441
    • Boto, T., Tomchik, S. M. The excitatory, the inhibitory, and the modulatory: mapping chemical neurotransmission in the brain Neuron  2019 101:763-765  DOI:10.1016/j.neuron.2019.02.021
    • Yu, D., Tan, Y., Chakraborty, M., Tomchik, S., Davis, R. L. Elongator complex is required for long-term olfactory memory formation in Drosophila Learning & Memory  2018 25:183-196  DOI:10.1101/lm.046557.117  PMID:29545390  PMCID:PMC5855525
    • Louis, T., Stahl, A., Boto, T., Tomchik, S. M. Cyclic AMP-dependent plasticity underlies rapid changes in odor coding associated with reward learning Proceedings of the National Academy of Sciences of the United States of America  2018 115:E448-E457  DOI:10.1073/pnas.1709037115  PMID:29284750  PMCID:PMC5776964
    • Murphy, K. R., Deshpande, S. A., Yurgel, M. E., Quinn, J. P., Weissbach, J. L., Keene, A. C., Dawson-Scully, K., Huber, R., Tomchik, S. M., Ja, W. W. Postprandial sleep mechanics in Drosophila Elife  2016 5  DOI:10.7554/eLife.19334  PMID:27873574  PMCID:PMC5119887
    • King, L. B., Koch, M., Murphy, K., Velazquez, Y., Ja, W. W., Tomchik, S. M. Neurofibromin loss of function drives excessive grooming in Drosophila G3-Genes Genomes Genetics  2016 6:1083-1093  DOI:10.1534/g3.115.026484  PMID:26896440  PMCID:PMC4825643
    • Louis, T., Tomchik, S. M. Neurons and behavior: ex uno, plures Cell  2014 159:713-714  DOI:10.1016/j.cell.2014.10.030  PMID:25417147
    • Boto, T., Louis, T., Jindachomthong, K., Jalink, K., Tomchik, S. M. Dopaminergic modulation of cAMP drives nonlinear plasticity across the Drosophila mushroom body lobes Current Biology  2014 24:822-831  DOI:10.1016/j.cub.2014.03.021  PMID:24684937  PMCID:PMC4019670
    • Tomchik, S. M. Dopaminergic neurons encode a distributed, asymmetric representation of temperature in drosophila Journal of Neuroscience  2013 33:2166-2176A  DOI:10.1523/jneurosci.3933-12.2013  PMID:23365252
    • Tomchik, S. M., Davis, R. L. Dynamics of learning-related cAMP signaling and stimulus integration in the Drosophila olfactory pathway Neuron  2009 64:510-521  DOI:10.1016/j.neuron.2009.09.029  PMID:19945393  PMCID:PMC4080329
    • Tomchik, S. M., Davis, R. L. Behavioural neuroscience: Out of sight, but not out of mind Nature  2008 453:1192-1194  DOI:10.1038/4531192a  PMID:18580936
    • Tomchik, S. M., Davis, R. L. Cyclic AMP imaging sheds light on PDF signaling in circadian clock neurons Neuron  2008 58:161-163  DOI:10.1016/j.neuron.2008.04.008  PMID:18439399
    • Dvoryanchikov, G., Tomchik, S. M., Chaudharv, N. Biogenic amine synthesis and uptake in rodent taste buds Journal of Comparative Neurology  2007 505:302-313  DOI:10.1002/cne.21494  PMID:17879273
    • Tomchik, S. M., Berg, S., Kim, J. W., Chaudhari, N., Roper, S. D. Breadth of tuning and taste coding in mammalian taste buds Journal of Neuroscience  2007 27:10840-10848  DOI:10.1523/jneurosci.1863-07.2007  PMID:17913917
    • Tomchik, S. M., Lu, Z. M. Modulation of auditory signal-to-noise ratios by efferent stimulation Journal of Neurophysiology  2006 95:3562-3570  DOI:10.1152/jn.00063.2006  PMID:16554519
    • Tomchik, S. M. Appetite for destruction: neuron ablations, prey capture, and sensorimotor integration in larval zebrafish Journal of Neuroscience  2006 26:1329-1330  DOI:10.1523/jneurosci.4401-05.2006  PMID:16452655
    • Tomchik, S. M., Lu, Z. M. Auditory physiology and anatomy of octavolateral efferent neurons in a teleost fish Journal of Comparative Physiology a-Neuroethology Sensory Neural and Behavioral Physiology  2006 192:51-67  DOI:10.1007/s00359-005-0050-0  PMID:16180037
    • Tomchik, S. M., Lu, Z. M. Octavolateral projections and organization in the medulla of a teleost fish, the sleeper goby (Dormitator latifrons) Journal of Comparative Neurology  2005 481:96-117  DOI:10.1002/cne.20363  PMID:15558734
    • Lu, Z., Tomchik, S. M. Effects of a red-tide toxin on fish hearing Journal of Comparative Physiology a-Neuroethology Sensory Neural and Behavioral Physiology  2002 188:807-813  DOI:10.1007/s00359-002-0369-8  PMID:12466956
  • thesis

    • Auditory role of the octavolateral efferent system in a teleost fish 2005

featured in

  • In Mapping Feat, Scripps Florida Scientists Pinpoint Neurons Where Select Memories Grow  News Release
  • Scripps Research Institute Appoints Memory Researcher to Faculty  News Release
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Research

research overview

  • The Tomchik Laboratory’s research focuses on how neuronal circuits encode and process sensory information, and how these representations of sensory stimuli are modified during the learning process. By studying the fundamental processes of learning in both normal animals and in models of human disease, our goal is to decipher how neurological disorders alter brain function and ultimately, behavior.

    Our research involves imaging brain function in near real time in the common fruit fly, Drosophila melanogaster. This animal has a tractable number of neurons, yet possesses olfactory circuits with remarkably similar architecture to those in other animals and humans. Our experiments involve imaging the brains of live flies while they are learning, revealing the firing patterns of neurons, as well as the spatial and temporal patterns of the activation of signaling molecules within the neurons. Simultaneously, manipulation of the activity of precise subsets of neurons is performed in order to study their roles in sensory perception and learning. Similar experiments are performed in animals with genetic mutations that mimic underlying brain disorders in humans.

    Ultimately, this research will shed light on how the brain functions in normal conditions, as well as how normal functions are disrupted in diseases. This knowledge is a fundamental requirement to develop directed treatments for brain disorders.
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Teaching

advisees

  • graduate advising relationship

    • Botero, Valentina, Ph.D.  candidate, 2019 -
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Background

education and training

  • Ph.D. in Biology, University of Miami , Robert E. Maytag Fellow; with Dr. Zhongmin Liu 2005
  • B.A. in Psychology, University of Miami , Honors Program cum laude 2001
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Contact

full name

  • Seth M. Tomchik

geographic location

  • Scripps Florida 

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