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Tiefenbrunn Sample, Theresa
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Tiefenbrunn Sample, Theresa

Graduate Student
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Positions

  • 2018 - Assistant Director, Patents, Ionis Pharmaceuticals

Websites

  • Doctoral Dissertation
  • Publications
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Publications

recent publications
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  • academic article

    • Deng, N., Forli, S., He, P., Perryman, A., Wickstrom, L., Vijayan, R. S. K., Tiefenbrunn, T., Stout, D., Gallicchio, E., Olson, A. J., Levy, R. M. Distinguishing binders from false positives by free energy calculations: fragment screening against the flap site of HIV protease Journal of Physical Chemistry B  2015 119:976-988  DOI:10.1021/jp506376z  PMID:25189630  PMCID:PMC4306491
    • Tiefenbrunn, T., Stout, C. D. Towards novel therapeutics for HIV through fragment-based screening and drug design Progress in Biophysics & Molecular Biology  2014 116:124-140  DOI:10.1016/j.pbiomolbio.2014.09.009  PMID:25455312
    • Tiefenbrunn, T., Forli, S., Happer, M., Gonzalez, A., Tsai, Y., Soltis, M., Elder, J. H., Olson, A. J., Stout, C. D. Crystallographic fragment-based drug discovery: use of a brominated fragment library targeting HIV protease Chemical Biology and Drug Design  2014 83:141-148  DOI:10.1111/cbdd.12227  PMID:23998903  PMCID:PMC3898673
    • Tiefenbrunn, T., Forli, S., Baksh, M. M., Chang, M. W., Happer, M., Lin, Y. C., Perryman, A. L., Rhee, J. K., Torbett, B. E., Olson, A. J., Elder, J. H., Finn, M. G., et al. Small molecule regulation of protein conformation by binding in the flap of HIV protease ACS Chemical Biology  2013 1223-1231  DOI:10.1021/cb300611p  PMID:23540839  PMCID:PMC3769432
    • Tsai, Y., McPhillips, S. E., Gonzalez, A., McPhillips, T. M., Zinn, D., Cohen, A. E., Feese, M. D., Bushnell, D., Tiefenbrunn, T., Stout, C. D., Ludaescher, B., Hedman, B., et al. AutoDrug: fully automated macromolecular crystallography workflows for fragment-based drug discovery Acta Crystallographica Section D-Biological Crystallography  2013 69:796-803  DOI:10.1107/s0907444913001984  PMID:23633588  PMCID:PMC3640469
    • Tiefenbrunn, T., Liu, W., Chen, Y., Katritch, V., Stout, C. D., Fee, J. A., Cherezov, V. High resolution structure of the ba3 cytochrome c oxidase from thermus thermophilus in a lipidic environment PLoS One  2011 6:e22348  DOI:10.1371/journal.pone.0022348  PMID:21814577  PMCID:PMC3141039
    • degree-related publication Tiefenbrunn, T. K., Blanco-Canosa, J., Dawson, P. E. Alternative chemistries for the synthesis of thrombospondin-1 type 1 repeats Biopolymers  2010 94:405-413  DOI:10.1002/bip.21486  PMID:20593462  PMCID:PMC2906232
    • degree-related publication Tiefenbrunn, T. K., Dawson, P. E. Chemoselective ligation techniques: modern applications of time-honored chemistry Biopolymers  2010 94:95-106  DOI:10.1002/bip.21337  PMID:20091876
    • degree-related publication Tiefenbrunn, T. K., Dawson, P. E. Chemical synthesis and biotinylation of the thrombospondin domain TSR2 Protein Science  2009 18:970-979  DOI:10.1002/pro.107  PMID:19384999  PMCID:PMC2771299
    • degree-related publication Yegneswaran, S., Tiefenbrunn, T. K., Fernandez, J. A., Dawson, P. E. Manipulation of thrombin exosite I, by ligand-directed covalent modification Journal of Thrombosis and Haemostasis  2007 5:2062-2069  DOI:10.1111/j.1538-7836.2007.02712.x  PMID:17883702
    • degree-related publication Clapp, A. R., Pons, T., Medintz, I. L., Delehanty, J. B., Melinger, J. S., Tiefenbrunn, T., Dawson, P. E., Fisher, B. R., O'Rourke, B., Mattoussi, H. Two-photon excitation of quantum-dot-based fluorescence resonance energy transfer and its applications Advanced Materials  2007 19:1921-1926  DOI:10.1002/adma.200602036
    • degree-related publication Medintz, I. L., Clapp, A. R., Brunel, F. M., Tiefenbrunn, T., Uyeda, H. T., Chang, E. L., Deschamps, J. R., Dawson, P. E., Mattoussi, H. Proteolytic activity monitored by fluorescence resonance energy transfer through quantum-dot-peptide conjugates Nature Materials  2006 5:581-589  DOI:10.1038/nmat1676  PMID:16799548
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Background

education and training

  • Ph.D. in Chemical Biology, Scripps Research 2004 - 2009
  • B.S. in Biology, California Institute of Technology 2000 - 2004

advisee of

  • graduate advising relationship

    • Dawson, Philip, Ph.D.  candidacy, 2005 - 2009
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Contact

full name

  • Theresa K Tiefenbrunn Sample

geographic location

  • Scripps California 

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