recent publications
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academic article
- Deng, N., Forli, S., He, P., Perryman, A., Wickstrom, L., Vijayan, R. S. K., Tiefenbrunn, T., Stout, D., Gallicchio, E., Olson, A. J., Levy, R. M. Distinguishing binders from false positives by free energy calculations: fragment screening against the flap site of HIV protease Journal of Physical Chemistry B 2015 119:976-988 DOI:10.1021/jp506376z PMID:25189630 PMCID:PMC4306491
- Tiefenbrunn, T., Stout, C. D. Towards novel therapeutics for HIV through fragment-based screening and drug design Progress in Biophysics & Molecular Biology 2014 116:124-140 DOI:10.1016/j.pbiomolbio.2014.09.009 PMID:25455312
- Tiefenbrunn, T., Forli, S., Happer, M., Gonzalez, A., Tsai, Y., Soltis, M., Elder, J. H., Olson, A. J., Stout, C. D. Crystallographic fragment-based drug discovery: use of a brominated fragment library targeting HIV protease Chemical Biology and Drug Design 2014 83:141-148 DOI:10.1111/cbdd.12227 PMID:23998903 PMCID:PMC3898673
- Tiefenbrunn, T., Forli, S., Baksh, M. M., Chang, M. W., Happer, M., Lin, Y. C., Perryman, A. L., Rhee, J. K., Torbett, B. E., Olson, A. J., Elder, J. H., Finn, M. G., et al. Small molecule regulation of protein conformation by binding in the flap of HIV protease ACS Chemical Biology 2013 1223-1231 DOI:10.1021/cb300611p PMID:23540839 PMCID:PMC3769432
- Tsai, Y., McPhillips, S. E., Gonzalez, A., McPhillips, T. M., Zinn, D., Cohen, A. E., Feese, M. D., Bushnell, D., Tiefenbrunn, T., Stout, C. D., Ludaescher, B., Hedman, B., et al. AutoDrug: fully automated macromolecular crystallography workflows for fragment-based drug discovery Acta Crystallographica Section D-Biological Crystallography 2013 69:796-803 DOI:10.1107/s0907444913001984 PMID:23633588 PMCID:PMC3640469
- Tiefenbrunn, T., Liu, W., Chen, Y., Katritch, V., Stout, C. D., Fee, J. A., Cherezov, V. High resolution structure of the ba3 cytochrome c oxidase from thermus thermophilus in a lipidic environment PLoS One 2011 6:e22348 DOI:10.1371/journal.pone.0022348 PMID:21814577 PMCID:PMC3141039
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Tiefenbrunn, T. K., Blanco-Canosa, J., Dawson, P. E.
Alternative chemistries for the synthesis of thrombospondin-1 type 1 repeats
Biopolymers
2010
94:405-413
DOI:10.1002/bip.21486
PMID:20593462
PMCID:PMC2906232
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Tiefenbrunn, T. K., Dawson, P. E.
Chemoselective ligation techniques: modern applications of time-honored chemistry
Biopolymers
2010
94:95-106
DOI:10.1002/bip.21337
PMID:20091876
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Tiefenbrunn, T. K., Dawson, P. E.
Chemical synthesis and biotinylation of the thrombospondin domain TSR2
Protein Science
2009
18:970-979
DOI:10.1002/pro.107
PMID:19384999
PMCID:PMC2771299
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Yegneswaran, S., Tiefenbrunn, T. K., Fernandez, J. A., Dawson, P. E.
Manipulation of thrombin exosite I, by ligand-directed covalent modification
Journal of Thrombosis and Haemostasis
2007
5:2062-2069
DOI:10.1111/j.1538-7836.2007.02712.x
PMID:17883702
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Clapp, A. R., Pons, T., Medintz, I. L., Delehanty, J. B., Melinger, J. S., Tiefenbrunn, T., Dawson, P. E., Fisher, B. R., O'Rourke, B., Mattoussi, H.
Two-photon excitation of quantum-dot-based fluorescence resonance energy transfer and its applications
Advanced Materials
2007
19:1921-1926
DOI:10.1002/adma.200602036
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Medintz, I. L., Clapp, A. R., Brunel, F. M., Tiefenbrunn, T., Uyeda, H. T., Chang, E. L., Deschamps, J. R., Dawson, P. E., Mattoussi, H.
Proteolytic activity monitored by fluorescence resonance energy transfer through quantum-dot-peptide conjugates
Nature Materials
2006
5:581-589
DOI:10.1038/nmat1676
PMID:16799548