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Teyton, Luc
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Teyton, Luc

Faculty Member
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Positions

  • 2017 - Professor, Immunology and Microbiology , Scripps Research
  • 1994 - Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
  • 2013 - 2017 Professor, Immunology and Microbial Science (IMS) , Scripps Research
Dr. Luc Teyton crystallizes and solves the structures of TCR/pMHC complexes in order to elucidate the molecular mechanisms by which the ligation of the T cell receptor to its ligand, an MHC-peptide complex, activates T cells.

Contact

  • lteyton@scripps.edu

Websites

  • Luc Teyton, M.D., Ph.D.
  • Laboratory Website
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Publications

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    • Gumperz, J., Kronenberg, M., Teyton, L. Editorial introduction Molecular Immunology  2019 114:269-269  DOI:10.1016/j.molimm.2019.08.001  PMID:31398666
    • Gioia, L., Holt, M., Costanzo, A., Sharma, S., Abe, B., Kain, L., Nakayama, M., Wan, X., Su, A., Mathews, C., Chen, Y. G., Unanue, E., et al. Position β57 of I-Ag7 controls early anti-insulin responses in NOD mice, linking an MHC susceptibility allele to type 1 diabetes onset Science Immunology  2019 4  DOI:10.1126/sciimmunol.aaw6329  PMID:31471352
    • Sharma, S., Pettus, J., Gottschalk, M., Abe, B., Gottlieb, P., Teyton, L. Single-cell analysis of CD4 T cells in type 1 diabetes: from mouse to man, how to perform mechanistic studies Diabetes  2019 68:1886-1891  DOI:10.2337/dbi18-0064  PMID:31540941
    • Holt, M., Costanzo, A., Gioia, L., Abe, B., Su, A. I., Teyton, L. Gene profiling and T cell receptor sequencing from antigen-specific CD4 T cells Methods in Molecular Biology  2018 1712:217-238  DOI:10.1007/978-1-4939-7514-3_14  PMID:29224077
    • Gavin, A. L., Huang, D., Huber, C., Martensson, A., Tardif, V., Skog, P. D., Blane, T. R., Thinnes, T. C., Osborn, K., Chong, H. S., Kargaran, F., Kimm, P., et al. PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing Nature Immunology  2018 19:942-953  DOI:10.1038/s41590-018-0179-y  PMID:30111894  PMCID:PMC6105523
    • Ito, Y., Ashenberg, O., Pyrdol, J., Luoma, A. M., Rozenblatt-Rosen, O., Hofree, M., Christian, E., de Andrade, L. F., Tay, R. E., Teyton, L., Regev, A., Dougan, S. K., et al. Rapid CLIP dissociation from MHC II promotes an unusual antigen presentation pathway in autoimmunity Journal of Experimental Medicine  2018 215:2617-2635  DOI:10.1084/jem.20180300  PMID:30185635  PMCID:PMC6170167
    • Fahl, S. P., Coffey, F., Kain, L., Zarin, P., Dunbrack, Jr., R. L., Teyton, L., Zuniga-Pflucker, J. C., Kappes, D. J., Wiest, D. L. Role of a selecting ligand in shaping the murine γδ-TCR repertoire Proceedings of the National Academy of Sciences of the United States of America  2018 115:1889-1894  DOI:10.1073/pnas.1718328115  PMID:29432160  PMCID:PMC5828614
    • Teyton, L. Role of lipid transfer proteins in loading CD1 antigen-presenting molecules Journal of Lipid Research  2018 59:1367-1373  DOI:10.1194/jlr.R083212  PMID:29559523  PMCID:PMC6071766
    • Sharma, S., Gioia, L., Abe, B., Holt, M., Costanzo, A., Kain, L., Su, A., Teyton, L. Using single cell analysis for translational studies in immune mediated diseases: Opportunities and challenges Molecular Immunology  2018 103:191-199  DOI:10.1016/j.molimm.2018.09.020  PMID:30300798  PMCID:PMC6258053
    • Montenegro-Burke, J. R., Aisporna, A. E., Benton, H. P., Rinehart, D., Fang, M., Huan, T., Warth, B., Forsberg, E., Abe, B. T., Iyanisevic, J., Wolan, D. W., Teyton, L., et al. Data streaming for metabolomics: accelerating data processing and analysis from days to minutes Analytical Chemistry  2017 89:1254-1259  DOI:10.1021/acs.analchem.6b03890  PMID:27983788  PMCID:PMC5244434
    • Teyton, L. New directions for natural killer T cells in the immunotherapy of cancer Frontiers in Immunology  2017 8  DOI:10.3389/fimmu.2017.01480
    • Deng, S., Kain, L., Pereira, C. S., Mata, S., Macedo, M. F., Bendelac, A., Teyton, L., Savage, P. B. Psychosine variants as antigens for natural killer T cells Chemical Science  2017 8:2204-2208  DOI:10.1039/c6sc04218j
    • Polonskaya, Z., Deng, S., Sarkar, A., Kain, L., Comellas-Aragones, M., McKay, C. S., Kaczanowska, K., Holt, M., McBride, R., Palomo, V., Self, K. M., Taylor, S., et al. T cells control the generation of nanomolar-affinity anti-glycan antibodies Journal of Clinical Investigation  2017 127:1491-1504  DOI:10.1172/jci91192  PMID:28287405  PMCID:PMC5373877
    • Boudinot, P., Mondot, S., Jouneau, L., Teyton, L., Lefranc, M. P., Lantz, O. Restricting nonclassical MHC genes coevolve with TRAV genes used by innate-like T cells in mammals Proceedings of the National Academy of Sciences of the United States of America  2016 113:E2983-E2992  DOI:10.1073/pnas.1600674113  PMID:27170188  PMCID:PMC4889381
    • Vartabedian, V. F., Savage, P. B., Teyton, L. The processing and presentation of lipids and glycolipids to the immune system Immunological Reviews  2016 272:109-119  DOI:10.1111/imr.12431  PMID:27319346  PMCID:PMC4916853
    • Kain, L., Costanzo, A., Webb, B., Holt, M., Bendelac, A., Savage, P. B., Teyton, L. Endogenous ligands of natural killer T cells are alpha-linked glycosylceramides Molecular Immunology  2015 68:94-97  DOI:10.1016/j.molimm.2015.06.009  PMID:26141240  PMCID:PMC4624034
    • Deng, S., Bai, L., Reboulet, R., Matthew, R., Engler, D. A., Teyton, L., Bendelac, A., Savage, P. B. A peptide-free, liposome-based oligosaccharide vaccine, adjuvanted with a natural killer T cell antigen, generates robust antibody responses Chemical Science  2014 5:1437-1441  DOI:10.1039/c3sc53471e  PMID:24683450  PMCID:PMC3966715
    • Tefit, J. N., Crabe, S., Orlandini, B., Nell, H., Bendelac, A., Deng, S., Savage, P. B., Teyton, L., Serra, V. Efficacy of ABX196, a new NKT agonist, in prophylactic human vaccination Vaccine  2014 32:6138-6145  DOI:10.1016/j.vaccine.2014.08.070  PMID:25218293  PMCID:PMC4233108
    • Kain, L., Webb, B., Anderson, B. L., Deng, S., Holt, M., Costanzo, A., Zhao, M., Self, K., Teyton, A., Everett, C., Kronenberg, M., Zajonc, D. M., et al. The identification of the endogenous ligands of natural killer T cells reveals the presence of mammalian α-linked glycosylceramides Immunity  2014 41:543-554  DOI:10.1016/j.immuni.2014.08.017  PMID:25367571  PMCID:PMC4220304
    • Presa, M., Ortiz, A. Z., Garabatos, N., Izquierdo, C., Rivas, E. I., Teyton, L., Mora, C., Serreze, D., Stratmann, T. Cholera toxin subunit B peptide fusion proteins reveal impaired oral tolerance induction in diabetes-prone but not in diabetes-resistant mice European Journal of Immunology  2013 43:2969-2979  DOI:10.1002/eji.201343633  PMID:23925934  PMCID:PMC3856580
    • Bai, L., Deng, S., Reboulet, R., Mathew, R., Teyton, L., Savage, P. B., Bendelac, A. Natural killer T (NKT)-B-cell interactions promote prolonged antibody responses and long-term memory to pneumococcal capsular polysaccharides Proceedings of the National Academy of Sciences of the United States of America  2013 110:16097-16102  DOI:10.1073/pnas.1303218110  PMID:24043771  PMCID:PMC3791701
    • Anderson, B. L., Teyton, L., Bendelac, A., Savage, P. B. Stimulation of natural killer T cells by glycolipids Molecules  2013 18:15662-15688  DOI:10.3390/molecules181215662  PMID:24352021  PMCID:PMC4018217
    • Freigang, S., Kain, L., Teyton, L. Transport and uptake of immunogenic lipids Molecular Immunology  2013 55:179-181  DOI:10.1016/j.molimm.2012.10.016  PMID:23174352  PMCID:PMC3612381
    • Komori, H. K., Witherden, D. A., Kelly, R., Sendaydiego, K., Jameson, J. M., Teyton, L., Havran, W. L. Cutting edge: dendritic epidermal gamma delta T cell ligands are rapidly and locally expressed by keratinocytes following cutaneous wounding Journal of Immunology  2012 188:2972-2976  DOI:10.4049/jimmunol.1100887  PMID:22393149  PMCID:PMC3311739
    • Bai, L., Constantinides, M. G., Thomas, S. Y., Reboulet, R., Meng, F. Y., Koentgen, F., Teyton, L., Savage, P. B., Bendelac, A. Distinct APCs explain the cytokine bias of alpha-galactosylceramide variants in vivo Journal of Immunology  2012 188:3053-3061  DOI:10.4049/jimmunol.1102414  PMID:22393151  PMCID:PMC3311697
    • Freigang, S., Landais, E., Zadorozhny, V., Kain, L., Yoshida, K., Liu, Y., Deng, S. L., Palinski, W., Savage, P. B., Bendelac, A., Teyton, L. Scavenger receptors target glycolipids for natural killer T cell activation Journal of Clinical Investigation  2012 122:3943-3954  DOI:10.1172/jci62267  PMID:23064364  PMCID:PMC3484437
    • Witherden, D. A., Watanabe, M., Garijo, O., Rieder, S. E., Sarkisyan, G., Cronin, S. J. F., Verdino, P., Wilson, I. A., Kumanogoh, A., Kikutani, H., Teyton, L., Fischer, W. H., et al. The CD100 receptor interacts with its plexin B2 ligand to regulate epidermal gamma delta T cell function Immunity  2012 37:314-325  DOI:10.1016/j.immuni.2012.05.026  PMID:22902232  PMCID:PMC3430606
    • Deng, S. L., Mattner, J., Zang, Z., Bai, L., Teyton, L., Bendelac, A., Savage, P. B. Impact of sugar stereochemistry on natural killer T cell stimulation by bacterial glycolipids Organic & Biomolecular Chemistry  2011 9:7659-7662  DOI:10.1039/c1ob06276j  PMID:21927724  PMCID:PMC3308336
    • Disse, J., Petersen, H. H., Larsen, K. S., Persson, E., Esmon, N., Esmon, C. T., Teyton, L., Petersen, L. C., Ruf, W. The endothelial protein C receptor supports tissue factor ternary coagulation initiation complex signaling through protease-activated receptors Journal of Biological Chemistry  2011 286:5756-5767  DOI:10.1074/jbc.M110.201228  PMID:21149441  PMCID:PMC3037688
    • Freigang, S., Zadorozhny, V., McKinney, M. K., Krebs, P., Herro, R., Pawlak, J., Kain, L., Schrantz, N., Masuda, K., Liu, Y., Savage, P. B., Bendelac, A., et al. Fatty acid amide hydrolase shapes NKT cell responses by influencing the serum transport of lipid antigen in mice Journal of Clinical Investigation  2010 120:1873-1884  DOI:10.1172/jci40451  PMID:20484813  PMCID:PMC2877940
    • Garcia, K. C., Degano, M., Stanfield, R. L., Brunmark, A., Jackson, M. R., Peterson, P. A., Teyton, L., Wilson, I. A. Pillars article: An alpha beta T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex (Science, 1996, 274:209-219) Journal of Immunology  2010 185:6402-6412  PMID:21084669
    • Yoshida, K., Corper, A. L., Herro, R., Jabri, B., Wilson, I. A., Teyton, L. The diabetogenic mouse MHC class II molecule I-A(g7) is endowed with a switch that modulates TCR affinity Journal of Clinical Investigation  2010 120:1578-1590  DOI:10.1172/jci41502  PMID:20407212  PMCID:PMC2860908
    • Witherden, D. A., Verdino, P., Rieder, S. E., Garijo, O., Mills, R. E., Teyton, L., Fischer, W. H., Wilson, I. A., Havran, W. L. The junctional adhesion molecule JAML is a costimulatory receptor for epithelial gamma delta T cell activation Science  2010 329:1205-1210  DOI:10.1126/science.1192698  PMID:20813954  PMCID:PMC2943937
    • Yin, N., Long, X., Goff, R. D., Zhou, D., Cantu, C., 3rd, Mattner, J., Mezard, P. S., Teyton, L., Bendelac, A., Savage, P. B. Alpha anomers of iGb3 and Gb3 stimulate cytokine production by natural killer T cells ACS Chemical Biology  2009 4:199-208  DOI:10.1021/cb800277n  PMID:19175331  PMCID:PMC2843501
    • Bai, L., Sagiv, Y., Liu, Y., Freigang, S., Yu, K. O. A., Teyton, L., Porcelli, S. A., Savage, P. B., Bendelac, A. Lysosomal recycling terminates CD1d-mediated presentation of short and polyunsaturated variants of the NKT cell lipid antigen alpha GalCer Proceedings of the National Academy of Sciences of the United States of America  2009 106:10254-10259  DOI:10.1073/pnas.0901228106  PMID:19506241  PMCID:PMC2693181
    • Landais, E., Romagnoli, P. A., Corper, A. L., Shires, J., Altman, J. D., Wilson, I. A., Garcia, K. C., Teyton, L. New design of MHC class II tetramers to accommodate fundamental principles of antigen presentation Journal of Immunology  2009 183:7949-7957  DOI:10.4049/jimmunol.0902493  PMID:19923463  PMCID:PMC2795019
    • Levin, D., DiPaolo, R. J., Brinster, C., Revilleza, M. J. R., Boyd, L. F., Teyton, L., Natarajan, K., Mage, M. G., Shevach, E. M., Margulies, D. H. Availability of autoantigenic epitopes controls phenotype, severity, and penetrance in TCR Tg autoimmune gastritis European Journal of Immunology  2008 38:3339-3353  DOI:10.1002/eji.200838584  PMID:19039784  PMCID:PMC2712832
    • Costantino, V., Fattorusso, E., Imperatore, C., Mangoni, A., Freigang, S., Teyton, L. Corrugoside, a new immunostimulatory alpha-galactoglycosphingolipid from the marine sponge Axinella corrugata Bioorganic & Medicinal Chemistry  2008 16:2077-2085  DOI:10.1016/j.bmc.2007.10.098  PMID:18037298
    • Zajonc, D. M., Savage, P. B., Bendelac, A., Wilson, I. A., Teyton, L. Crystal structures of mouse CD1d-iGb3 complex and its cognate v alpha 14 T cell receptor suggest a model for dual recognition of foreign and self glycolipids Journal of Molecular Biology  2008 377:1104-1116  DOI:10.1016/j.jmb.2008.01.061  PMID:18295796  PMCID:PMC2579742
    • Mattner, J., Savage, P. B., Leung, P., Oertelt, S. S., Wang, V., Trivedi, O., Scanlon, S. T., Pendem, K., Teyton, L., Hart, J., Ridgway, W. M., Wicker, L. S., et al. Liver autoimmunity triggered by microbial activation of natural killer T cells Cell Host & Microbe  2008 3:304-315  DOI:10.1016/j.chom.2008.03.009  PMID:18474357  PMCID:PMC2453520
    • Liu, Y., Deng, S., Bai, L., Freigang, S., Mattner, J., Teyton, L., Bendelac, A., Savage, P. B. Synthesis of diglycosylceramides and evaluation of their iNKT cell stimulatory properties Bioorganic & Medicinal Chemistry Letters  2008 18:3052-3055  DOI:10.1016/j.bmcl.2007.12.067  PMID:18206371  PMCID:PMC2846726
    • Shore, D. A., Issafras, H., Landais, E., Teyton, L., Wilson, I. A. The crystal structure of CD8 in complex with YTS156.7.7 Fab and interaction with other CD8 antibodies define the binding mode of CD8 alphabeta to MHC class I Journal of Molecular Biology  2008 384:1190-1202  DOI:10.1016/j.jmb.2008.09.069  PMID:18929574  PMCID:PMC2631232
    • Hovhannisyan, Z., Weiss, A., Martin, A., Wiesner, M., Tollefsen, S., Yoshida, K., Ciszewski, C., Curran, S. A., Murray, J. A., David, C. S., Sollid, L. M., Koning, F., et al. The role of HLA-DQ8 beta 57 polymorphism in the anti-gluten T-cell response in coeliac disease Nature  2008 456:534-538  DOI:10.1038/nature07524  PMID:19037317  PMCID:PMC3784325
    • Sagiv, Y., Bai, L., Wei, D. G., Agami, R., Savage, P. B., Teyton, L., Bendelac, A. A distal effect of microsomal triglyceride transfer protein deficiency on the lysosomal recycling of CD1d Journal of Experimental Medicine  2007 204:921-928  DOI:10.1084/jem.20061568  PMID:17403933  PMCID:PMC2118556
    • Scherer, E. M., Zwick, M. B., Teyton, L., Burton, D. R. Difficulties in eliciting broadly neutralizing anti-HIV antibodies are not explained by cardiolipin autoreactivity AIDS  2007 21:2131-2139  DOI:10.1097/QAD.0b013e3282a4a632  PMID:18090039
    • Homann, D., Lewicki, H., Brooks, D., Eberlein, J., Mallet-Designe, V., Teyton, L., Oldstone, M. B. A. Mapping and restriction of a dominant viral CD4(+) T cell core epitope by both MHC class I and MHC class II Virology  2007 363:113-123  DOI:10.1016/j.virol.2006.12.025  PMID:17320138  PMCID:PMC1976554
    • Novak, J., Beaudoin, L., Park, S., Griseri, T., Teyton, L., Bendelac, A., Lehuen, A. Prevention of type 1 diabetes by invariant NKT cells is independent of peripheral CD1d expression Journal of Immunology  2007 178:1332-1340  PMID:17237379
    • Long, X. T., Deng, S., Mattner, J. C., Zang, Z., Zhou, D., McNary, N., Goff, R. D., Teyton, L., Bendelac, A., Savage, P. B. Synthesis and evaluation of stimulatory properties of Sphingomonadaceae glycolipids Nature Chemical Biology  2007 3:559-564  DOI:10.1038/nchembio.2007.19  PMID:17660835
    • Schrantz, N., Sagiv, Y., Liu, Y., Savage, P. B., Bendelac, A., Teyton, L. The Niemann-Pick type C2 protein loads isoglobotrihexosylceramide onto CD1d molecules and contributes to the thymic selection of NKT cells Journal of Experimental Medicine  2007 204:841-852  DOI:10.1084/jem.20061562  PMID:17389239  PMCID:PMC2118543
    • Bendelac, A., Savage, P. B., Teyton, L. The biology of NKT cells Annual Review of Immunology  2007 25:297-336  DOI:10.1146/annurev.immunol.25.022106.141711  PMID:17150027
    • Teyton, L. The saga of MHC-bound peptides: a renaissance for antigen presentation? Journal of Clinical Investigation  2007 117:3164-3166  DOI:10.1172/jci33997  PMID:17975658  PMCID:PMC2045625
    • Liu, Y., Goff, R. D., Zhou, D. P., Mattner, J., Sullivan, B. A., Khurana, A., Cantu, C., Ravkov, E. V., Lbegbu, C. C., Altman, J. D., Teyton, L., BendelaC, A., et al. A modified alpha-galactosyl ceramide for staining and stimulating natural killer T cells Journal of Immunological Methods  2006 312:34-39  DOI:10.1016/j.jim.2006.02.009  PMID:16647712
    • Shore, D. A., Teyton, L., Dwek, R. A., Rudd, P. M., Wilson, I. A. Crystal structure of the TCR co-receptor CD8 alpha alpha in complex with monoclonal antibody YTS 105.18 Fab fragment at 2.88 A resolution Journal of Molecular Biology  2006 358:347-354  DOI:10.1016/j.jmb.2006.02.016  PMID:16530222
    • Sagiv, Y., Hudspeth, K., Mattner, J., Schrantz, N., Stern, R. K., Zhou, D. P., Savage, P. B., Teyton, L., Bendelac, A. Cutting edge: Impaired glycosphingolipid trafficking and NKT cell development in mice lacking Niemann-Pick type C1 protein Journal of Immunology  2006 177:26-30  PMID:16785493
    • Savage, P. B., Teyton, L., Bendelac, A. Glycolipids for natural killer T cells Chemical Society Reviews  2006 35:771-779  DOI:10.1039/b510638a  PMID:16936925
    • Brooks, D. G., Trifilo, M. J., Edelmann, K. H., Teyton, L., McGavern, D. B., Oldstone, M. B. A. Interleukin-10 determines viral clearance or persistence in vivo Nature Medicine  2006 12:1301-1309  DOI:10.1038/nm1492  PMID:17041596  PMCID:PMC2535582
    • Wei, D. G., Curran, S. A., Savage, P. B., Teyton, L., Bendelac, A. Mechanisms imposing the V beta bias of V alpha 14 natural killer T cells and consequences for microbial glycolipid recognition Journal of Experimental Medicine  2006 203:1197-1207  DOI:10.1084/jem.20060418  PMID:16651387  PMCID:PMC2121203
    • Benlagha, K., Wei, D. G., Veiga, J., Teyton, L., Bendelac, A. Characterization of the early stages of thymic NKT cell development Journal of Experimental Medicine  2005 202:485-492  DOI:10.1084/jem.20050456  PMID:16087715  PMCID:PMC2212852
    • Mattner, J., DeBord, K. L., Ismail, N., Goff, R. D., Cantu, C., Zhou, D. P., Saint-Mezard, P., Wang, V., Gao, Y., Yin, N., Hoebe, K., Schneewind, O., et al. Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections Nature  2005 434:525-529  DOI:10.1038/nature03408  PMID:15791258
    • Wei, D. G., Lee, H., Park, S. H., Beaudoin, L., Teyton, L., Lehuen, A., Bendelac, A. Expansion and long-range differentiation of the NKT cell lineage in mice expressing CD1d exclusively on cortical thymocytes Journal of Experimental Medicine  2005 202:239-248  DOI:10.1084/jem.20050413  PMID:16027237  PMCID:PMC2213013
    • Brooks, D. G., Teyton, L., Oldstone, M. B. A., McGavern, D. B. Intrinsic functional dysregulation of CD4 T cells occurs rapidly following persistent viral infection Journal of Virology  2005 79:10514-10527  DOI:10.1128/jvi.79.16.10514-10527.2005  PMID:16051844  PMCID:PMC1182641
    • Zajonc, D. M., Cantu, C., Mattner, J., Zhou, D. P., Savage, P. B., Bendelac, A., Wilson, I. A., Teyton, L. Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor Nature Immunology  2005 6:810-818  DOI:10.1038/ni1224  PMID:16007091  PMCID:PMC2045075
    • Malherbe, L., Hausl, C., Teyton, L., McHeyzer-Williams, M. G. Clonal selection of helper T cells is determined by an affinity threshold with no further skewing of TCR binding properties Immunity  2004 21:669-679  DOI:10.1016/j.immuni.2004.09.008  PMID:15539153
    • Kelker, M. S., Foss, T. R., Peti, W., Teyton, L., Kelly, J. W., Wuthrich, K., Wilson, I. A. Crystal structure of human triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.47 A Journal of Molecular Biology  2004 342:1237-1248  DOI:10.1016/j.jmb.2004.07.089  PMID:15351648
    • Reiser, J. B., Teyton, L., Wilson, I. A. Crystal structure of the Drosophila peptidoglycan recognition protein (PGRP)-SA at 1.56 A resolution Journal of Molecular Biology  2004 340:909-917  DOI:10.1016/j.jmb.2004.04.077  PMID:15223330
    • Zhou, D. P., Cantu, C., Sagiv, Y., Schrantz, N., Kulkarni, A. B., Qi, X. Y., Mahuran, D. J., Morales, C. R., Grabowski, G. A., Benlagha, K., Savage, P., Bendelac, A., et al. Editing of CD1d-bound lipid antigens by endosomal lipid transfer proteins Science  2004 303:523-527  DOI:10.1126/science.1092009  PMID:14684827  PMCID:PMC2918537
    • Goff, R. D., Gao, Y., Mattner, J., Zhou, D. P., Yin, N., Cantu, C., Teyton, L., Bendelac, A., Savage, P. B. Effects of lipid chain lengths in alpha-galactosylceramides on cytokine release by natural killer T cells Journal of the American Chemical Society  2004 126:13602-13603  DOI:10.1021/ja045385q  PMID:15493902
    • Cantu 3rd, C., Teyton, L. Linking lipid metabolism to immunity: the role of lipid transfer proteins in the selection of iNKT cells Discovery Medicine  2004 4:115-117  PMID:20705005
    • Zhou, D. P., Mattner, J., Cantu, C., Schrantz, N., Yin, N., Gao, Y., Sagiv, Y., Hudspeth, K., Wu, Y. P., Yamashita, T., Teneberg, S., Wang, D. C., et al. Lysosomal glycosphingolipid recognition by NKT cells Science  2004 306:1786-1789  DOI:10.1126/science/1103440  PMID:15539565
    • Ranheim, E. A., Tarbell, K. V., Krogsgaard, M., Mallet-Designe, V., Teyton, L., McDevitt, H. O., Weissman, I. L. Selection of aberrant class II restricted CD8(+) T cells in NOD mice expressing a glutamic acid decarboxylase (GAD) 65-specific T cell receptor transgene Autoimmunity  2004 37:555-567  DOI:10.1080/08916930400020545  PMID:15763918
    • Mitra, A. K., Celia, H., Ren, G., Luz, J. G., Wilson, I. A., Teyton, L. Supine orientation of a murine MHC class I molecule on the membrane bilayer Current Biology  2004 14:718-724  DOI:10.1016/j.cub.2004.04.004  PMID:15084288
    • Robey, I. F., Peterson, M., Horwitz, M. S., Kono, D. H., Stratmann, T., Theofilopoulos, A. N., Sarvetnick, N., Teyton, L., Feeney, A. J. Terminal deoxynucleotidyltransferase deficiency decreases autoimmune disease in diabetes-prone nonobese diabetic mice and lupus-prone MRL-Fas(lpr) mice Journal of Immunology  2004 172:4624-4629  PMID:15034081
    • Zajonc, D. M., Elsliger, M. A., Teyton, L., Wilson, I. A. Crystal structure of CD1a in complex with a sulfatide self antigen at a resolution of 2.15 A Nature Immunology  2003 4:808-815  DOI:10.1038/ni948  PMID:12833155
    • Zhu, Y. R., Rudensky, A. Y., Corper, A. L., Teyton, L., Wilson, I. A. Crystal structure of MHC class II I-Ab in complex with a human CLIP peptide: prediction of an I-Ab peptide-binding motif Journal of Molecular Biology  2003 326:1157-1174  DOI:10.1016/s0022-2836(02)01437-7  PMID:12589760
    • Mallet-Designe, V. I., Stratmann, T., Homann, D., Carbone, F., Oldstone, M. B. A., Teyton, L. Detection of low-avidity CD4(+) T cells using recombinant artificial APC: following the antiovalbumin immune response Journal of Immunology  2003 170:123-131  PMID:12496391
    • Stratmann, T., Martin-Orozco, N., Mallet-Designe, V., Poirot, L., McGavern, D., Losyev, G., Dobbs, C. M., Oldstone, M. B. A., Yoshida, K., Kikutani, H., Mathis, D., Benoist, C., et al. Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity Journal of Clinical Investigation  2003 112:902-914  DOI:10.1172/jci200318337  PMID:12975475  PMCID:PMC193666
    • Forestier, C., Park, S. H., Wei, D. S., Benlagha, K., Teyton, L., Bendelac, A. T cell development in mice expressing CD1d directed by a classical MHC class II promoter Journal of Immunology  2003 171:4096-4104  PMID:14530331
    • Cantu, C., Benlagha, K., Savage, P. B., Bendelac, A., Teyton, L. The paradox of immune molecular recognition of alpha-galactosylceramide: low affinity, low specificity for CD1d, high affinity for alpha beta TCRs Journal of Immunology  2003 170:4673-4682  PMID:12707346
    • Benlagha, K., Kyin, T., Beavis, A., Teyton, L., Bendelac, A. A thymic precursor to the NK T cell lineage Science  2002 296:553-555  DOI:10.1126/science.1069017  PMID:11968185
    • Tarbell, K. V., Lee, M., Ranheim, E., Chao, C. C., Sanna, M., Kim, S. K., Dickie, P., Teyton, L., Davis, M., McDevitt, H. CD4(+) T cells from glutamic acid decarboxylase (GAD)65-specific T cell receptor transgenic mice are not diabetogenic and can delay diabetes transfer Journal of Experimental Medicine  2002 196:481-492  DOI:10.1084/jem.20011845  PMID:12186840  PMCID:PMC2196059
    • Apostolopoulos, V., Yu, M. M., Corper, A. L., Li, W. J., McKenzie, I. F. C., Teyton, L., Wilson, I. A. Crystal structure of a non-canonical high affinity peptide complexed with MHC class I: a novel use of alternative anchors Journal of Molecular Biology  2002 318:1307-1316  DOI:10.1016/s0022-2836(02)00198-5  PMID:12083519
    • Apostolopoulos, V., Yu, M. M., Corper, A. L., Teyton, L., Pietersz, G. A., McKenzie, I. F. C., Wilson, I. A. Crystal structure of a non-canonical low-affinity peptide complexed with MHC class I: a new approach for vaccine design Journal of Molecular Biology  2002 318:1293-1305  DOI:10.1016/s0022-2836(02)00196-1  PMID:12083518
    • Lee, P. T., Benlagha, K., Teyton, L., Bendelac, A. Distinct functional lineages of human V(alpha)24 natural killer T cells Journal of Experimental Medicine  2002 195:637-641  DOI:10.1084/jem.20011908  PMID:11877486  PMCID:PMC2193771
    • Procopio, D. O., Almeida, I. C., Torrecilhas, A. C. T., Cardoso, J. E., Teyton, L., Travassos, L. R., Bendelac, A., Gazzinelli, R. T. Glycosylphosphatidylinositol-anchored mucin-like glycoproteins from Trypanosoma cruzi bind to CD1d but do not elicit dominant innate or adaptive immune responses via the CD1d/NKT cell pathway Journal of Immunology  2002 169:3926-3933  PMID:12244192
    • Bendelac, A., Teyton, L., Savage, P. B. Lipid presentation by CDI: the short and the long lipid story Nature Immunology  2002 3:421-422  DOI:10.1038/ni0502-421  PMID:11976717
    • Chiu, Y. H., Park, S. H., Benlagha, K., Forestier, C., Jayawardena-Wolf, J., Savage, P. B., Teyton, L., Bendelac, A. Multiple defects in antigen presentation and T cell development by mice expressing cytoplasmic tail-truncated CD1d Nature Immunology  2002 3:55-60  DOI:10.1038/ni740  PMID:11731798
    • Stetson, D. B., Mohrs, M., Mallet-Designe, V., Teyton, L., Locksley, R. M. Rapid expansion and IL-4 expression by Leishmania-specific naive helper T cells in vivo Immunity  2002 17:191-200  DOI:10.1016/s1074-7613(02)00363-1  PMID:12196290
    • Luz, J. G., Huang, M. D., Garcia, C., Rudolph, M. G., Apostolopoulos, V., Teyton, L., Wilson, I. A. Structural comparison of allogeneic and syngeneic T cell receptor-peptide-major histocompatibility complex complexes: a buried alloreactive mutation subtly alters peptide presentation substantially increasing V(beta) Interactions Journal of Experimental Medicine  2002 195:1175-1186  DOI:10.1084/jem.20011644  PMID:11994422  PMCID:PMC2193710
    • Zhou, X. T., Forestier, C., Goff, R. D., Li, C. H., Teyton, L., Bendelac, A., Savage, P. B. Synthesis and NKT cell stimulating properties of fluorophore- and biotin-appended 6 ''-amino-6 ''-deoxy-galactosylceramides Organic Letters  2002 4:1267-1270  DOI:10.1021/ol025565+  PMID:11950339
    • Lee, P. T., Putnam, A., Benlagha, K., Teyton, L., Gottlieb, P. A., Bendelac, A. Testing the NKT cell hypothesis of human IDDM pathogenesis Journal of Clinical Investigation  2002 110:793-800  DOI:10.1172/jci200215832  PMID:12235110  PMCID:PMC151131
    • Honey, K., Benlagha, K., Beers, C., Forbush, K., Teyton, L., Kleijmeer, M. J., Rudensky, A. Y., Bendelac, A. Thymocyte expression of cathepsin L is essential for NKT cell development Nature Immunology  2002 3:1069-1074  DOI:10.1038/ni844  PMID:12368909
    • Rudolph, M. G., Huang, M. D., Teyton, L., Wilson, I. A. Crystal structure of an isolated V(alpha) domain of the 2C T-cell receptor Journal of Molecular Biology  2001 314:1-8  DOI:10.1006/jmbi.2001.5113  PMID:11724527
    • Wolan, D. W., Teyton, L., Rudolph, M. G., Villmow, B., Bauer, S., Busch, D. H., Wilson, I. A. Crystal structure of the murine NK cell-activating receptor NKG2D at 1.95 A Nature Immunology  2001 2:248-254  DOI:10.1038/85311  PMID:11224525
    • Homann, D., Teyton, L., Oldstone, M. B. A. Differential regulation of antiviral T-cell immunity results in stable CD8(+) but declining CD4(+) T-cell memory Nature Medicine  2001 7:913-919  DOI:10.1038/90950  PMID:11479623
    • Rudolph, M. G., Speir, J. A., Brunmark, A., Mattsson, N., Jackson, M. R., Peterson, P. A., Teyton, L., Wilson, I. A. The crystal structures of K(bm1) and K(bm8) reveal that subtle changes in the peptide environment impact thermostability and alloreactivity Immunity  2001 14:231-242  DOI:10.1016/s1074-7613(01)00105-4  PMID:11290333
    • Park, S. H., Weiss, A., Benlagha, K., Kyin, T., Teyton, L., Bendelac, A. The mouse CD1d-restricted repertoire is dominated by a few autoreactive T cell receptor families Journal of Experimental Medicine  2001 193:893-904  DOI:10.1084/jem.193.8.893  PMID:11304550  PMCID:PMC2193401
    • Degano, M., Garcia, K. C., Apostolopoulos, V., Rudolph, M. G., Teyton, L., Wilson, I. A. A functional hot spot for antigen recognition in a superagonist TCR/MHC complex Immunity  2000 12:251-261  DOI:10.1016/s1074-7613(00)80178-8  PMID:10755612
    • Crowley, M. P., Fahrer, A. M., Baumgarth, N., Hampl, J., Gutgemann, I., Teyton, L., Chien, Y. H. A population of murine gamma delta T cells that recognize an inducible MHC class Ib molecule Science  2000 287:314-316  DOI:10.1126/science.287.5451.314  PMID:10634788
    • Corper, A. L., Stratmann, T., Apostolopoulos, V., Scott, C. A., Garcia, K. C., Kang, A. S., Wilson, I. A., Teyton, L. A structural framework for deciphering the link between I-A(g7) and autoimmune diabetes Science  2000 288:505-511  DOI:10.1126/science.288.5465.505  PMID:10775108
    • Teyton, L., Apostolopoulos, V., Cantu, C., Celia, H., Mallet-Designe, V., Stefanko, R., Stratmann, T., Wallace, M. Function and dysfunction of T cell receptor: structural studies Immunologic Research  2000 21:325-330  DOI:10.1385/ir:21:2-3:325  PMID:10852133
    • Benlagha, K., Weiss, A., Beavis, A., Teyton, L., Bendelac, A. In vivo identification of glycolipid antigen-specific T cells using fluorescent CD1d tetramers Journal of Experimental Medicine  2000 191:1895-1903  PMID:10839805  PMCID:PMC2213523
    • Stratmann, T., Apostolopoulos, V., Mallet-Designe, V., Corper, A. L., Scott, C. A., Wilson, I. A., Kang, A. S., Teyton, L. The I-Ag7 MHC class II molecule linked to murine diabetes is a promiscuous peptide binder Journal of Immunology  2000 165:3214-3225  PMID:10975837
    • Manning, T. C., Parke, E. A., Teyton, L., Kranz, D. M. Effects of complementarity determining region mutations on the affinity of an alpha/beta T cell receptor: measuring the energy associated with CD4/CD8 repertoire skewing Journal of Experimental Medicine  1999 189:461-470  DOI:10.1084/jem.189.3.461  PMID:9927508  PMCID:PMC2192906
    • Kieke, M. C., Shusta, E. V., Boder, E. T., Teyton, L., Wittrup, K. D., Kranz, D. M. Selection of functional T cell receptor mutants from a yeast surface-display library Proceedings of the National Academy of Sciences of the United States of America  1999 96:5651-5656  DOI:10.1073/pnas.96.10.5651  PMID:10318939  PMCID:PMC21915
    • Garcia, K. C., Teyton, L., Wilson, L. A. Structural basis of T cell recognition Annual Review of Immunology  1999 17:369-397  DOI:10.1146/annurev.immunol.17.1.369  PMID:10358763
    • Celia, H., Wilson-Kubalek, E., Milligan, R. A., Teyton, L. Structure and function of a membrane-bound murine MHC class I molecule Proceedings of the National Academy of Sciences of the United States of America  1999 96:5634-5639  DOI:10.1073/pnas.96.10.5634  PMID:10318936  PMCID:PMC21912
    • Manning, T. C., Schlueter, C. J., Brodnicki, T. C., Parke, E. A., Speir, J. A., Garcia, K. C., Teyton, L., Wilson, I. A., Kranz, D. M. Alanine scanning mutagenesis of an alpha beta T cell receptor: mapping the energy of antigen recognition Immunity  1998 8:413-425  DOI:10.1016/s1074-7613(00)80547-6  PMID:9586632
    • Liljedahl, M., Winqvist, O., Surh, C. D., Wong, P., Ngo, K., Teyton, L., Peterson, P. A., Brunmark, A., Rudensky, A. Y., Fung-Leung, W. P., Karlsson, L. Altered antigen presentation in mice lacking H2-O Immunity  1998 8:233-243  DOI:10.1016/s1074-7613(00)80475-6  PMID:9492004
    • Luxembourg, A. T., Borrow, P., Teyton, L., Brunmark, A. B., Peterson, P. A., Jackson, M. R. Biomagnetic isolation of antigen-specific CD8(+) T cells usable in immunotherapy Nature Biotechnology  1998 16:281-285  DOI:10.1038/nbt0398-281  PMID:9528010
    • Scott, C. A., Peterson, P. A., Teyton, L., Wilson, I. A. Crystal structures of two I-A(d)-peptide complexes reveal that high affinity can be achieved without large anchor residues Immunity  1998 8:319-329  DOI:10.1016/s1074-7613(00)80537-3  PMID:9529149
    • Scott, C. A., Garcia, K. C., Stura, E. A., Peterson, P. A., Wilson, I. A., Teyton, L. Engineering protein for X-ray crystallography: the murine major histocompatibility complex class II molecule I-A(d) Protein Science  1998 7:413-418  DOI:10.1002/pro.5560070222  PMID:9521118  PMCID:PMC2143914
    • Cai, Z. L., Brunmark, A. B., Luxembourg, A. T., Garcia, K. C., Degano, M., Teyton, L., Wilson, I., Peterson, P. A., Sprent, J., Jackson, M. R. Probing the activation requirements for naive CD8(+) T cells with Drosophila cell transfectants as antigen presenting cells Immunological Reviews  1998 165:249-265  DOI:10.1111/j.1600-065X.1998.tb01243.x  PMID:9850865
    • Speir, J. A., Garcia, K. C., Brunmark, A., Degano, M., Peterson, P. A., Teyton, L., Wilson, I. A. Structural basis of 2C TCR allorecognition of H-2L(d) peptide complexes Immunity  1998 8:553-562  DOI:10.1016/s1074-7613(00)80560-9  PMID:9620676
    • Garcia, K. C., Degano, M., Pease, L. R., Huang, M. D., Peterson, P. A., Teyton, L., Wilson, I. A. Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen Science  1998 279:1166-1172  DOI:10.1126/science.279.5354.1166  PMID:9469799
    • Garcia, K. C., Teyton, L. T-cell receptor peptide-MHC interactions: biological lessons from structural studies Current Opinion in Biotechnology  1998 9:338-343  DOI:10.1016/s0958-1669(98)80004-9  PMID:9720260
    • Aichinger, G., Karlsson, L., Jackson, M. R., Vestberg, M., Vaughan, J. H., Teyton, L., Lechler, R. I., Peterson, P. A. Major histocompatibility complex class II-dependent unfolding, transport, and degradation of endogenous proteins Journal of Biological Chemistry  1997 272:29127-29136  DOI:10.1074/jbc.272.46.29127  PMID:9360989
    • Smirnov, A. V., English, D. S., Rich, R. L., Lane, J., Teyton, L., Schwabacher, A. W., Luo, S., Thornburg, R. W., Petrich, J. W. Photophysics and biological applications of 7-azaindole and its analogs Journal of Physical Chemistry B  1997 101:2758-2769  DOI:10.1021/jp9630232
    • Garcia, K. C., Tallquist, M. D., Pease, L. R., Brunmark, A., Scott, C. A., Degano, M., Stura, E. A., Peterson, P. A., Wilson, I. A., Teyton, L. αβ T cell receptor interactions with syngeneic and allogeneic ligands: affinity measurements and crystallization Proceedings of the National Academy of Sciences of the United States of America  1997 94:13838-13843  DOI:10.1073/pnas.94.25.13838  PMID:9391114  PMCID:PMC28394
    • Eastman, S., Deftos, M., DeRoos, P. C., Hsu, D. H., Teyton, L., Braunstein, N. S., Hackett, C. J., Rudensky, A. A study of complexes of class II invariant chain peptide: major histocompatibility complex class II molecules using a new complex-specific monoclonal antibody European Journal of Immunology  1996 26:385-393  DOI:10.1002/eji.1830260218  PMID:8617308
    • Huang, J. F., Teyton, L., Harper, J. F. Activation of a Ca(2+)-dependent protein kinase involves intramolecular binding of a calmodulin-like regulatory domain Biochemistry  1996 35:13222-13230  DOI:10.1021/bi960498a  PMID:8855961
    • Garcia, K. C., Degano, M., Stanfield, R. L., Brunmark, A., Jackson, M. R., Peterson, P. A., Teyton, L., Wilson, I. A. An alpha beta T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex Science  1996 274:209-219  DOI:10.1126/science.274.5285.209  PMID:8824178
    • Lang, J., Jackson, M., Teyton, L., Brunmark, A., Kane, K., Nemazee, D. B cells are exquisitely sensitive to central tolerance and receptor editing induced by ultralow affinity, membrane-bound antigen Journal of Experimental Medicine  1996 184:1685-1697  DOI:10.1084/jem.184.5.1685  PMID:8920858  PMCID:PMC2192881
    • Garcia, K. C., Scott, C. A., Brunmark, A., Carbone, F. R., Peterson, P. A., Wilson, I. A., Teyton, L. CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes Nature  1996 384:577-581  DOI:10.1038/384577a0  PMID:8955273
    • Scott, C. A., Garcia, K. C., Carbone, F. R., Wilson, I. A., Teyton, L. Role of chain pairing for the production of functional soluble IA major histocompatibility complex class II molecules Journal of Experimental Medicine  1996 183:2087-2095  DOI:10.1084/jem.183.5.2087  PMID:8642319  PMCID:PMC2192579
    • Pond, L., Kuhn, L. A., Teyton, L., Schutze, M. P., Tainer, J. A., Jackson, M. R., Peterson, P. A. A role for acidic residues in di-leucine motif-based targeting to the endocytic pathway Journal of Biological Chemistry  1995 270:19989-19997  PMID:7650016
    • Jackson, M. R., Fruh, K., Karlsson, L., Teyton, L., Yang, Y., Peterson, P. A. Assembly and intracellular transport of MHC class I and class II molecules Cold Spring Harbor Symposia on Quantitative Biology  1995 60:249-261  DOI:10.1101/SQB.1995.060.01.029  PMID:8824398
    • Teyton, L. Assembly and transport of major histocompatibility complex molecules Nouvelle Revue Francaise d Hematologie  1994 36:S33-S36  PMID:7909942
    • Teyton, L., Peterson, P. A. Assembly and transport of MHC class II molecules New Biologist  1992 4:441-447  PMID:1515409
    • Teyton, L., Peterson, P. A. Invariant chain: a regulator of antigen presentation Trends in Cell Biology  1992 2:52-56  DOI:10.1016/0962-8924(92)90163-H  PMID:14731527
    • Temime, N., Joliviere, A., Lando, D., Teyton, L., Charron, D. Autocrine stimulation of interleukin 1 in human adherent synovial lining cells: down regulation by interferon gamma Human Immunology  1991 31:261-270  DOI:10.1016/0198-8859(91)90098-t  PMID:1917593
    • Lotteau, V., Teyton, L., Peleraux, A., Nilsson, T., Karlsson, L., Schmid, S. L., Quaranta, V., Peterson, P. A. Intracellular transport of class II MHC molecules directed by invariant chain Nature  1990 348:600-605  DOI:10.1038/348600a0  PMID:2250716
    • Teyton, L., Osullivan, D., Dickson, P. W., Lotteau, V., Sette, A., Fink, P., Peterson, P. A. Invariant chain distinguishes between the exogenous and endogenous antigen presentation pathways Nature  1990 348:39-44  DOI:10.1038/348039a0  PMID:2234057
    • Lotteau, V., Sands, J., Teyton, L., Turmel, P., Charron, D., Strominger, J. L. Modulation of HLA class II antigen expression by transfection of sense and antisense DR alpha cDNA Journal of Experimental Medicine  1989 169:351-356  DOI:10.1084/jem.169.1.351  PMID:2462612  PMCID:PMC2189193
    • Mauviel, A., Teyton, L., Bhatnagar, R., Penfornis, H., Laurent, M., Hartmann, D., Bonaventure, J., Loyau, G., Saklatvala, J., Pujol, J. P. Interleukin-1 alpha modulates collagen gene expression in cultured synovial cells Biochemical Journal  1988 252:247-255  PMID:2844146  PMCID:PMC1149130
    • Lotteau, V., Teyton, L., Burroughs, D., Charron, D. A novel HLA class II molecule (DR alpha-DQ beta) created by mismatched isotype pairing Nature  1987 329:339-341  DOI:10.1038/329339a0  PMID:3306409
    • Lotteau, V., Teyton, L., Tongio, M. M., Soulier, A., Thomsen, M., Sasportes, M., Charron, D. Biochemical polymorphism of the HLA-DP heavy chain Immunogenetics  1987 25:403-407  DOI:10.1007/bf00396107  PMID:3596675
    • Teyton, L., Lotteau, V., Brandely, M., Turmel, P., Viguier, M., Pujol, J. P., Loyau, G., Charron, D. J. Effects of cyclosporine A (cy A) on IFN-gamma induction of Ia antigens on adherent synovial lining cells (ASLC) International Congress Series  1987 718:159-163
    • Teyton, L., Lotteau, V., Turmel, P., Arenzanaseisdedos, F., Virelizier, J. L., Pujol, J. P., Loyau, G., Piatiertonneau, D., Auffray, C., Charron, D. J. HLA DR, DQ, and DP antigen expression in rheumatoid synovial cells: a biochemical and quantitative study Journal of Immunology  1987 138:1730-1738  PMID:3102596
    • Arenzana-Seisdedos, F., Teyton, L., Virelizier, J. L. Immunoregulatory mediators in the pathogenesis of rheumatoid arthritis Scandinavian Journal of Rheumatology  1987 16:13-17  PMID:3131870
    • Teyton, L., Lotteau, V., Boyer, B., Charron, D. J. A quantitative dot immunobinding assay for human HLA class II antigens using nitrocellulose membrane filters Journal of Immunological Methods  1986 89:73-79  DOI:10.1016/0022-1759(86)90033-5  PMID:3517174
    • Charron, D. J., Haziot, A., Lotteau, V., Neel, D., Merlu, B., Teyton, L. Biochemical diversity of the human MHC class II antigens Experimental Biology and Medicine  1986 13:61-72  DOI:10.1007/978-1-4612-5014-2_6
    • Charron, D. J., Lotteau, V., Haziot, A., Teyton, L., Merlu, B., Neel, D. Molecular diversity of the human Ia system Immune Intervention  1986 2:1-12
    • Teyton, L., Pouletty, P. [Le lupus erythemateux dissemine: physiopathologie, diagnostic, evolution et pronostic] Concours Medical  1985 107:3311
    • Teyton, L., Mora, J. J., Loyau, G., Mahoudeau, J., L'Hirondel, J. L., Lebrun, E., Dumas, M., Ollivier, D. [Cleidocranial dysostosis. Contribution to its study apropos of 2 personal cases (an isolated and a familial form)] Revue de Medecine Interne  1984 5:76-82  PMID:6718841
    • Guaydier-Souquieres, G., Teyton, L., Loyau, G., L'Hirondel, J. L. [Metastase synoviale revelatrice d'un adenocarcinome] LARC Medical  1983 3:300
    • Teyton, L., Loyau, G., Freymuth, F. [Rheumatoid arthritis: current ideas about pathogenesis and the possible role of the Epstein-Barr virus] Revue De Medecine  1983 24:13-17
    • Teyton, L., Mora, J. J., Loyau, G. [Scanner et bilan d'un abces pottique] LARC Medical  1983 3:309
    • Mora, J. J., Teyton, L., Loyau, G., Ollivier, D. [Tuberculosis complicating the course of acute systemic lupus erythematosus] LARC Medical  1983 3:417-418  PMID:6888110
    • Mora, J. J., Teyton, L., Souquieres, G., L'Hirondel, J. L., Loyau, G. [Metastase synoviale revelatrice d'un adenocarcinome] Rhumatologie  1982 34:499
    • Teyton, L. [Traitement des brucelloses osteo-articulaires] NPM Medecine  1981 10:729
    • Freymuth, F., Langeard, M. M., Daon, F., Teyton, L., Guihard, P., L'Hirondel, J. L., Venezia, R. [Infections a virus respiratoire syncitial] Revue de l Institut Pasteur de Lyon  1980 13:111
  • thesis

    • [Expression des antigenes HLA de classe II sur les cellules synoviales humaines normales et rhumatoides] 1987

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research overview

  • Structural Studies of T Cell Functions and Dysfunction

    My laboratory is trying to elucidate the molecular mechanisms by which the ligation of the T cell receptor to its ligand, an MHC-peptide complex, activates T cells. To this aim we have crystallized and solved the structure of two TCR/pMHC complexes. No conformational changes were evidenced in these complexes. We are trying now to reconstruct a larger TCR complex including CD3 dimers and CD4/CD8 molecules. Similar studies are carried out on TCR/pMHC pairs involved in autoimmune diseases with two additional goals. First, identify self-peptides involved in autoimmunity. Secondly, measure the affinity of self MHC-self pMHC complexes and determine if pathogenic T cells arise from escaping negative selection or breakage of peripheral tolerance. The corollary question is to determine if autoimmunity is a deviance of a normal immune response or the innate property of a T cell response against a self antigen. The answers to these questions will be determinant in choosing new therapeutic strategies.
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Teaching

advisees

  • graduate advising relationship

    • Clarke, Don, Ph.D.  candidate, 2018 -
    • Sharma, Siddhartha Mohan, Ph.D.  candidate, 2016 -
    • Vartabedian, Vincent, Ph.D.  candidate, 2016 -
    • Polonskaya, Zinaida M, Ph.D.  candidate, 2009 - 2014
  • postdoc or fellow advising relationship

    • Polonskaya, Zinaida M, Ph.D.  candidate, 2015 -
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Background

education and training

  • Ph.D. in Immunology, University of Paris Diderot (Paris VII) , with special Honors from the Jury 1987
  • M.D. in Medicine, University of Caen Lower Normandy , School of Medicine, with special Honors from the Jury 1980
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Contact

full name

  • Luc Teyton

geographic location

  • Scripps California 
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Identity

ORCID iD

  • ORCID iD http://orcid.org/0000-0002-4049-1583

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