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Telenti, Amalio
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Telenti, Amalio

Faculty Member Adjunct
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Positions

  • 2019 - Professor Adjunct, Integrative Structural and Computational Biology (ISCB) , Scripps Research
  • 2017 - Chief Data Scientist, Translational Institute , Scripps Research
  • 2015 - Health Sciences Clinical Professor Adjunct, Skaggs School of Pharmceutical Sciences, Department of Medicine, University of California, San Diego
  • 2017 - 2019 Professor of Genomics, Integrative Structural and Computational Biology (ISCB) , Scripps Research
  • 2016 - 2017 Chief Data Scientist/Chief Scientific Officer, Human Longevity
  • 2014 - 2016 Head, Genomics, Human Longevity
  • 2014 - 2016 Head, Functional Biology, Human Longevity
  • 2007 - 2014 Director, Institute of Microbiology, University Hospital Center, University of Lausanne
  • 2003 - 2014 Professor of Medical Virology, University of Lausanne
  • 2003 - 2007 Head, Medical Virology, Co-Director, Institute of Microbiology, University of Lausanne
  • 2002 - 2003 Associate Professor of Infectious Diseases, University of Lausanne
  • 1997 - 2003 Chief, HIV Unit, Division of Infectious Diseases, Lausanne University Hospital, University of Lausanne
  • 1995 - 1997 Assistant Professor, University of Bern, Switzerland
Amalio Telenti works on large scale analysis of human whole genome sequences. He led the analysis of the first 10,000 deep whole genome sequences. His current research focuses on advancing the understanding on the 98% of the human genome that is dedicated to regulation of the remaining 2% (protein coding genome) and to the analysis of the features of human genes essential for life.

Contact

  • atelenti@scripps.edu

Websites

  • Amalio Telenti, M.D., Ph.D.
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Publications

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  • 51

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    • Telenti, A., di Iulio, J. Regulatory genome variants in human susceptibility to infection Human Genetics  2020  DOI:10.1007/s00439-019-02091-9  PMID:31807864
    • Telenti, A., Jiang, X. Q. Treating medical data as a durable asset Nature Genetics  2020 52:1005-1010  DOI:10.1038/s41588-020-0698-y  PMID:32929286
    • Telenti, A. Machine learning to decode genomics Clinical Chemistry  2020 66:45-47  DOI:10.1373/clinchem.2019.308296  PMID:31601562
    • Dall'Agnese, A., Caputo, L., Nicoletti, C., di Iulio, J., Schmitt, A., Gatto, S., Diao, Y., Ye, Z., Forcato, M., Perera, R., Bicciato, S., Telenti, A., et al. Transcription factor-directed re-wiring of chromatin architecture for somatic cell nuclear reprogramming toward trans-differentiation Molecular Cell  2019 76:453-+  DOI:10.1016/j.molcel.2019.07.036  PMID:31519520  PMCID:PMC6842445
    • Hicks, M., Bartha, I., di Iulio, J., Venter, J. C., Telenti, A. Functional characterization of 3D protein structures informed by human genetic diversity Proceedings of the National Academy of Sciences of the United States of America  2019 116:8960-8965  DOI:10.1073/pnas.1820813116  PMID:30988206  PMCID:PMC6500140
    • Dobrowolski, C., Valadkhan, S., Graham, A. C., Shukla, M., Ciuffi, A., Telenti, A., Karn, J. Entry of polarized effector cells into quiescence forces HIV latency MBio  2019 10:e00337-19  DOI:10.1128/mBio.00337-19  PMID:30914509  PMCID:PMC6437053
    • Cirulli, E. T., Guo, L., Swisher, C. L., Shah, N., Huang, L., Napier, L. A., Kirkness, E. F., Spector, T. D., Caskey, C. T., Thorens, B., Venter, J. C., Telenti, A. Profound perturbation of the metabolome in obesity is associated with health risk Cell Metabolism  2019 29:488-500  DOI:10.1016/j.cmet.2018.09.022  PMID:30318341  PMCID:PMC6370944
    • Zou, J., Huss, M., Abid, A., Mohammadi, P., Torkamani, A., Telenti, A. A primer on deep learning in genomics Nature Genetics  2019 51:12-18  DOI:10.1038/s41588-018-0295-5  PMID:30478442
    • Iranmehr, A., Stobdan, T., Zhou, D., Poulsen, O., Strohl, K. P., Aldashev, A., Telenti, A., Wong, E. H. M., Kirkness, E. F., Venter, J. C., Bafna, V., Haddad, G. G. Novel insight into the genetic basis of high-altitude pulmonary hypertension in Kyrgyz highlanders European Journal of Human Genetics  2019 27:150-159  DOI:10.1038/s41431-018-0270-8  PMID:30254217  PMCID:PMC6303266
    • Telenti, A. Integrating metabolomics with genomics Pharmacogenomics  2018 19:1377-1381  DOI:10.2217/pgs-2018-0155  PMID:30398072
    • Telenti, A., Lippert, C., Chang, P. C., DePristo, M. Deep learning of genomic variation and regulatory network data Human Molecular Genetics  2018 27:R63-R71  DOI:10.1093/hmg/ddy115  PMID:29648622
    • Telenti, A., Steinhubl, S. R., Topol, E. J. Rethinking the medical record Lancet  2018 391:1013-1013  PMID:29565009
    • di Iulio, J., Bartha, I., Wong, E. H. M., Yu, H. C., Lavrenko, V., Yang, D. C., Jung, I., Hicks, M. A., Shah, N., Kirkness, E. F., Fabani, M. M., Biggs, W. H., et al. The human noncoding genome defined by genetic diversity Nature Genetics  2018 50:333-337  DOI:10.1038/s41588-018-0062-7  PMID:29483654
    • Choi, Y., Chan, A. P., Kirkness, E., Telenti, A., Schork, N. J. Comparison of phasing strategies for whole human genomes PLoS Genetics  2018 14  DOI:10.1371/journal.pgen.1007308  PMID:29621242  PMCID:PMC5903673
    • Bartha, I., di Iulio, J., Venter, J. C., Telenti, A. Human gene essentiality Nature Reviews Genetics  2018 19:51-62  DOI:10.1038/nrg.2017.75  PMID:29082913
    • Stobdan, T., Akbari, A., Azad, P., Zhou, D., Poulsen, O., Appenzeller, O., Gonzales, G. F., Telenti, A., Wong, E. H. M., Saini, S., Kirkness, E. F., Venter, J. C., et al. New insights into the genetic basis of Monge's disease and adaptation to high-altitude Molecular Biology and Evolution  2017 34:3154-3168  DOI:10.1093/molbev/msx239  PMID:29029226
    • Martinez-Picado, J., McLaren, P. J., Telenti, A., Izquierdo-Useros, N. Retroviruses as myeloid cell riders: what natural human Siglec-1 "knockouts" tell us about pathogenesis Frontiers in Immunology  2017 8  DOI:10.3389/fimmu.2017.01593  PMID:29209326  PMCID:PMC5702442
    • Tang, H., Kirkness, E. F., Lippert, C., Biggs, W. H., Fabani, M., Guzman, E., Ramakrishnan, S., Lavrenko, V., Kakaradov, B., Hou, C., Hicks, B., Heckerman, D., et al. Profiling of short-tandem-repeat disease alleles in 12,632 human whole genome American Journal of Human Genetics  2017 101:700-715  DOI:10.1016/j.ajhg.2017.09.013  PMID:29100084  PMCID:PMC5673627
    • Wang, S., Jiang, X., Tang, H., Wang, X., Bu, D. Y., Carey, K., Dyke, S. O. M., Fox, D., Jiang, C., Lauter, K., Malin, B., Sofia, H., et al. A community effort to protect genomic data sharing, collaboration and outsourcing NPJ Genomic Medicine  2017 2  DOI:10.1038/s41525-017-0036-1  PMID:29263842  PMCID:PMC5677972
    • Pan, X., Wang, Y., Wong, E. H. M., Telenti, A., Venter, J. C., Jin, L. Fine population structure analysis method for genomes of many Scientific Reports  2017 7  DOI:10.1038/s41598-017-12319-1  PMID:28974706  PMCID:PMC5626719
    • Rato, S., Rausell, A., Munoz, M., Telenti, A., Ciuffi, A. Single-cell analysis identifies cellular markers of the HIV permissive cell PLoS Pathogens  2017 13  DOI:10.1371/journal.ppat.1006678  PMID:29073251  PMCID:PMC5658171
    • Asgari, S., Schlapbach, L. J., Anchisi, S., Hammer, C., Bartha, I., Junier, T., Mottet-Osman, G., Posfay-Barbe, K. M., Longchamp, D., Stocker, M., Cordey, S., Kaiser, L., et al. Severe viral respiratory infections in children with IFIH1 loss-of-function mutations Proceedings of the National Academy of Sciences of the United States of America  2017 114:8342-8347  DOI:10.1073/pnas.1704259114  PMID:28716935  PMCID:PMC5547624
    • Xie, C., Yeo, Z. X., Wong, M., Piper, J., Long, T., Kirkness, E. F., Biggs, W. H., Bloom, K., Spellman, S., Vierra-Green, C., Brady, C., Scheuermann, R. H., et al. Fast and accurate HLA typing from short-read next-generation sequence data with xHLA Proceedings of the National Academy of Sciences of the United States of America  2017 114:8059-8064  DOI:10.1073/pnas.1707945114  PMID:28674023  PMCID:PMC5544337
    • Rato, S., Golumbeanu, M., Telenti, A., Ciuffi, A. Exploring viral infection using single-cell sequencing Virus Research  2017 239:55-68  DOI:10.1016/j.virusres.2016.10.016  PMID:27816430
    • Rajagopala, S. V., Vashee, S., Oldfield, L. M., Suzuki, Y., Venter, J. C., Telenti, A., Nelson, K. E. The human microbiome and cancer Cancer Prevention Research  2017 10:226-234  DOI:10.1158/1940-6207.capr-16-0249  PMID:28096237
    • Long, T., Hicks, M., Yu, H. C., Biggs, W. H., Kirkness, E. F., Menni, C., Zierer, J., Small, K. S., Mangino, M., Messier, H., Brewerton, S., Turpaz, Y., et al. Whole-genome sequencing identifies common-to-rare variants associated with human blood metabolites Nature Genetics  2017 49:568-578  DOI:10.1038/ng.3809  PMID:28263315
    • Chen, F., Wang, S., Jiang, X., Ding, S., Lu, Y., Kim, J., Sahinalp, S. C., Shimizu, C., Burns, J. C., Wright, V. J., Png, E., Hibberd, M. L., et al. PRINCESS: Privacy-protecting Rare disease International Network Collaboration via Encryption through Software guard extensionS Bioinformatics  2017 33:871-878  DOI:10.1093/bioinformatics/btw758  PMID:28065902
    • Moustafa, A., Xie, C., Kirkness, E., Biggs, W., Wong, E., Turpaz, Y., Bloom, K., Delwart, E., Nelson, K. E., Venter, J. C., Telenti, A. The blood DNA virome in 8,000 humans PLoS Pathogens  2017 13  DOI:10.1371/journal.ppat.1006292  PMID:28328962  PMCID:PMC5378407
    • Bartha, I., McLaren, P. J., Brumme, C., Harrigan, R., Telenti, A., Fellay, J. Estimating the respective contributions of human and viral genetic variation to HIV control PLoS Computational Biology  2017 13  DOI:10.1371/journal.pcbi.1005339  PMID:28182649  PMCID:PMC5300119
    • Humbert, M., Ayday, E., Hubaux, J. P., Telenti, A. Quantifying interdependent risks in genomic privacy ACM Transactions on Privacy and Security  2017 20  DOI:10.1145/3035538
    • Lippert, C., Sabatini, R., Maher, M. C., Kang, E. Y., Lee, S., Arikan, O., Harley, A., Bernal, A., Garst, P., Lavrenko, V., Yocum, K., Wong, T., et al. Identification of individuals by trait prediction using whole-genome sequencing data Proceedings of the National Academy of Sciences of the United States of America  2017 114:10166-10171  DOI:10.1073/pnas.1711125114  PMID:28874526  PMCID:PMC5617305
    • Gustafson, K., Duncan, J. L., Biswas, P., Soto-Hermida, A., Matsui, H., Jakubosky, D., Suk, J., Telenti, A., Frazer, K. A., Ayyagari, R. Whole genome sequencing revealed mutations in two independent genes as the underlying cause of retinal degeneration in an Ashkenazi Jewish pedigree Genes  2017 8  DOI:10.3390/genes8090210  PMID:28837078  PMCID:PMC5615344
    • Branham, K., Matsui, H., Biswas, P., Guru, A. A., Hicks, M., Suk, J. J., Li, H., Jakubosky, D., Long, T., Telenti, A., Nariai, N., Heckenlively, J. R., et al. Establishing the involvement of the novel gene AGBL5 in retinitis pigmentosa by whole genome sequencing Physiological Genomics  2016 48:922-927  DOI:10.1152/physiolgenomics.00101.2016  PMID:27764769  PMCID:PMC5206392
    • Telenti, A., Pierce, L. C. T., Biggs, W. H., di Iulio, J., Wong, E. H. M., Fabani, M. M., Kirkness, E. F., Moustafa, A., Shah, N., Xie, C., Brewerton, S. C., Bulsara, N., et al. Deep sequencing of 10,000 human genomes Proceedings of the National Academy of Sciences of the United States of America  2016 113:11901-11906  DOI:10.1073/pnas.1613365113  PMID:27702888  PMCID:PMC5081584
    • Tang, H., Jiang, X., Wang, X., Wang, S., Sofia, H., Fox, D., Lauter, K., Malin, B., Telenti, A., Xiong, L., Ohno-Machado, L. Protecting genomic data analytics in the cloud: state of the art and opportunities BMC Medical Genomics  2016 9  DOI:10.1186/s12920-016-0224-3  PMID:27733153  PMCID:PMC5062944
    • Martinez-Picado, J., McLaren, P. J., Erkizia, I., Martin, M. P., Benet, S., Rotger, M., Dalmau, J., Ouchi, D., Wolinsky, S. M., Penugonda, S., Gunthard, H. F., Fellay, J., et al. Identification of Siglec-1 null individuals infected with HIV-1 Nature Communications  2016 7  DOI:10.1038/ncomms12412  PMID:27510803  PMCID:PMC4987525
    • McLaren, P. J., Raisaro, J. L., Aouri, M., Rotger, M., Ayday, E., Bartha, I., Delgado, M. B., Vallet, Y., Gunthard, H. F., Cavassini, M., Furrer, H., Doco-Lecompte, T., et al. Privacy-preserving genomic testing in the clinic: a model using HIV treatment Genetics in Medicine  2016 18:814-822  DOI:10.1038/gim.2015.167  PMID:26765343  PMCID:PMC4985613
    • Rausell, A., Munoz, M., Martinez, R., Roger, T., Telenti, A., Ciuffi, A. Innate immune defects in HIV permissive cell lines Retrovirology  2016 13  DOI:10.1186/s12977-016-0275-8  PMID:27350062  PMCID:PMC4924258
    • Telenti, A., Perkins, B. A., Venter, J. C. Dynamics of an aging genome Cell Metabolism  2016 23:949-950  DOI:10.1016/j.cmet.2016.06.002  PMID:27304490
    • Ciuffi, A., Rato, S., Telenti, A. Single-cell genomics for virology Viruses  2016 8  DOI:10.3390/v8050123  PMID:27153082  PMCID:PMC4885078
    • Krapp, C., Hotter, D., Gawanbacht, A., McLaren, P. J., Kluge, S. F., Sturzel, C. M., Mack, K., Reith, E., Engelhart, S., Ciuffi, A., Hornung, V., Sauter, D., et al. Guanylate binding protein (GBP) 5 is an interferon-inducible inhibitor of HIV-1 infectivity Cell Host & Microbe  2016 19:504-514  DOI:10.1016/j.chom.2016.02.019  PMID:26996307
    • Aouri, M., Barcelo, C., Ternon, B., Cavassini, M., Anagnostopoulos, A., Yerly, S., Hugues, H., Vernazza, P., Gunthard, H. F., Buclin, T., Telenti, A., Rotger, M., et al. In vivo profiling and distribution of known and novel phase I and phase II metabolites of efavirenz in plasma, urine, and cerebrospinal fluid Drug Metabolism and Disposition  2016 44:151-161  DOI:10.1124/dmd.115.065839  PMID:26553012
    • Alcala, N., Jensen, J. D., Telenti, A., Vuilleumier, S. The genomic signature of population reconnection following Isolation: from theory to HIV G3-Genes Genomes Genetics  2016 6:107-120  DOI:10.1534/g3.115.024208  PMID:26546308  PMCID:PMC4704709
    • Bartha, I., Rausell, A., McLaren, P. J., Mohammadi, P., Tardaguila, M., Chaturvedi, N., Fellay, J., Telenti, A. The characteristics of heterozygous protein truncating variants in the human genome PLoS Computational Biology  2015 11  DOI:10.1371/journal.pcbi.1004647  PMID:26642228  PMCID:PMC4671652
    • McLaren, P. J., Coulonges, C., Bartha, I., Lenz, T. L., Deutsch, A. J., Bashirova, A., Buchbinder, S., Carrington, M. N., Cossarizza, A., Dalmau, J., De Luca, A., Goedert, J. J., et al. Polymorphisms of large effect explain the majority of the host genetic contribution to variation of HIV-1 virus load Proceedings of the National Academy of Sciences of the United States of America  2015 112:14658-14663  DOI:10.1073/pnas.1514867112  PMID:26553974  PMCID:PMC4664299
    • Julia, M., Telenti, A., Rausell, A. Sincell: an R/Bioconductor package for statistical assessment of cell-state hierarchies from single-cell RNA-seq Bioinformatics  2015 31:3377-3379  DOI:10.1093/bioinformatics/btv368  PMID:26099264  PMCID:PMC4595899
    • Perkins, M. R., Bartha, I., Timmer, J. K., Liebner, J. C., Wollinsky, D., Gunthard, H. F., Hauser, C., Bernasconi, E., Hoffmann, M., Calmy, A., Battegay, M., Telenti, A., et al. The interplay between host genetic variation, viral replication, and microbial translocation in untreated HIV-infected individuals Journal of Infectious Diseases  2015 212:578-584  DOI:10.1093/infdis/jiv089  PMID:25701868  PMCID:PMC4539895
    • Cummins, N. W., Neuhaus, J., Chu, H., Neaton, J., Wyen, C., Rockstroh, J. K., Skiest, D. J., Boyd, M. A., Khoo, S., Rotger, M., Telenti, A., Weinshilboum, R., et al. Investigation of Efavirenz discontinuation in multi-ethnic populations of HIV-positive individuals by genetic analysis EBiomedicine  2015 2:706-712  DOI:10.1016/j.ebiom.2015.05.012  PMID:26288843  PMCID:PMC4534686
    • McLaren, P. J., Gawanbacht, A., Pyndiah, N., Krapp, C., Hotter, D., Kluge, S. F., Gotz, N., Heilmann, J., Mack, K., Sauter, D., Thompson, D., Perreaud, J., et al. Identification of potential HIV restriction factors by combining evolutionary genomic signatures with functional analyses Retrovirology  2015 12  DOI:10.1186/s12977-015-0165-5  PMID:25980612  PMCID:PMC4434878
    • Pino, M., Erkizia, I., Benet, S., Erikson, E., Fernandez-Figueras, M. T., Guerrero, D., Dalmau, J., Ouchi, D., Rausell, A., Ciuffi, A., Keppler, O. T., Telenti, A., et al. HIV-1 immune activation induces Siglec-1 expression and enhances viral trans-infection in blood and tissue myeloid cells Retrovirology  2015 12  DOI:10.1186/s12977-015-0160-x  PMID:25947229  PMCID:PMC4423124
    • Zirafi, O., Kim, K. A., Standker, L., Mohr, K. B., Sauter, D., Heigele, A., Kluge, S. F., Wiercinska, E., Chudziak, D., Richter, R., Moepps, B., Gierschik, P., et al. Discovery and characterization of an endogenous CXCR4 antagonist Cell Reports  2015 11:737-747  DOI:10.1016/j.celrep.2015.03.061  PMID:25921529
    • Ciuffi, A., Mohammadi, P., Golumbeanu, M., di Iulio, J., Telenti, A. Bioinformatics and HIV latency Current HIV/AIDS Reports  2015 12:97-106  DOI:10.1007/s11904-014-0240-x  PMID:25586146  PMCID:PMC4369283
    • Pyndiah, N., Telenti, A., Rausell, A. Evolutionary genomics and HIV restriction factors Current Opinion in HIV and AIDS  2015 10:79-83  DOI:10.1097/coh.0000000000000138  PMID:25594315
    • Telenti, A. Genomics of HIV infection Current Opinion in HIV and AIDS  2015 10:77-78  DOI:10.1097/coh.0000000000000140  PMID:25612323
    • Guidi, M., Foletti, G., McLaren, P., Cavassini, M., Rauch, A., Tarr, P. E., Lamy, O., Panchaud, A., Telenti, A., Csajka, C., Rotger, M. Vitamin D time profile based on the contribution of non-genetic and genetic factors in HIV-infected individuals of European ancestry Antiviral Therapy  2015 20:261-269  DOI:10.3851/imp2823  PMID:25032819
    • Rausell, A., Telenti, A. Genomics of host-pathogen interactions Current Opinion in Immunology  2014 30:32-38  DOI:10.1016/j.coi.2014.06.001  PMID:24972384
    • Buzon, M. J., Martin-Gayo, E., Pereyra, F., Ouyang, Z., Sun, H., Li, J. Z., Piovoso, M., Shaw, A., Dalmau, J., Zangger, N., Martinez-Picado, J., Zurakowski, R., et al. Long-term antiretroviral treatment initiated at primary HIV-1 infection affects the size, composition, and decay kinetics of the reservoir of HIV-1-infected CD4 T cells Journal of Virology  2014 88:10056-10065  DOI:10.1128/jvi.01046-14  PMID:24965451  PMCID:PMC4136362
    • Telenti, A. HIV: The mixed blessing of interferon Nature  2014 511:537-538  DOI:10.1038/nature13517  PMID:25043060
    • Gunthard, H. F., Aberg, J. A., Eron, J. J., Hoy, J. F., Telenti, A., Benson, C. A., Burger, D. M., Cahn, P., Gallant, J. E., Glesby, M. J., Reiss, P., Saag, M. S., et al. Antiretroviral treatment of adult HIV infection: 2014 recommendations of the International Antiviral Society-USA Panel JAMA-Journal of the American Medical Association  2014 312:410-425  DOI:10.1001/jama.2014.8722  PMID:25038359
    • Rausell, A., Mohammadi, P., McLaren, P. J., Bartha, I., Xenarios, I., Fellay, J., Telenti, A. Analysis of stop-gain and frameshift variants in human innate immunity genes PLoS Computational Biology  2014 10  DOI:10.1371/journal.pcbi.1003757  PMID:25058640  PMCID:PMC4110073
    • Izquierdo-Useros, N., Lorizate, M., McLaren, P. J., Telenti, A., Krausslich, H. G., Martinez-Picado, J. HIV-1 capture and transmission by dendritic cells: the role of viral glycolipids and the cellular receptor Siglec-1 PLoS Pathogens  2014 10  DOI:10.1371/journal.ppat.1004146  PMID:25033082  PMCID:PMC4102576
    • Dalmau, J., Rotger, M., Erkizia, I., Rauch, A., Reche, P., Pino, M., Esteve, A., Palou, E., Brander, C., Paredes, R., Phung, P., Clotet, B., et al. Highly pathogenic adapted HIV-1 strains limit host immunity and dictate rapid disease progression AIDS  2014 28:1261-1272  DOI:10.1097/qad.0000000000000293  PMID:24732774
    • Mohammadi, P., di Iulio, J., Munoz, M., Martinez, R., Bartha, I., Cavassini, M., Thorball, C., Fellay, J., Beerenwinkel, N., Ciuffi, A., Telenti, A. Dynamics of HIV latency and reactivation in a primary CD4+ T cell model. PLoS Pathogens  2014 10  DOI:10.1371/journal.ppat.1004156  PMID:24875931  PMCID:PMC4038609
    • Clifford, R., Louis, T., Robbe, P., Ackroyd, S., Burns, A., Timbs, A. T., Colopy, G. W., Dreau, H., Sigaux, F., Judde, J. G., Rotger, M., Telenti, A., et al. SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage Blood  2014 123:1021-1031  DOI:10.1182/blood-2013-04-490847  PMID:24335234  PMCID:PMC3924925
    • Regoes, R. R., McLaren, P. J., Battegay, M., Bernasconi, E., Calmy, A., Gunthard, H. F., Hoffmann, M., Rauch, A., Telenti, A., Fellay, J. Disentangling human tolerance and resistance against HIV PLoS Biology  2014 12  DOI:10.1371/journal.pbio.1001951  PMID:25226169  PMCID:PMC4165755
    • Bartha, I., McLaren, P. J., Ciuffi, A., Fellay, J., Telenti, A. GuavaH: a compendium of host genomic data in HIV biology and disease Retrovirology  2014 11  DOI:10.1186/1742-4690-11-6  PMID:24428872  PMCID:PMC3937115
    • Bashirova, A. A., Martin-Gayo, E., Jones, D. C., Qi, Y., Apps, R., Gao, X., Burke, P. S., Taylor, C. J., Rogich, J., Wolinsky, S., Bream, J. H., Duggal, P., et al. LILRB2 interaction with HLA class I correlates with control of HIV-1 infection PLoS Genetics  2014 10  DOI:10.1371/journal.pgen.1004196  PMID:24603468  PMCID:PMC3945438
    • Bartha, I., Carlson, J. M., Brumme, C. J., McLaren, P. J., Brumme, Z. L., John, M., Haas, D. W., Martinez-Picado, J., Dalmau, J., Lopez-Galindez, C., Casado, C., Rauch, A., et al. A genome-to-genome analysis of associations between human genetic variation, HIV-1 sequence diversity, and viral control Elife  2013 2  DOI:10.7554/eLife.01123  PMID:24171102  PMCID:PMC3807812
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    • Thomas, R., Apps, R., Qi, Y., Gao, X., Male, V., O'HUigin, C., O'Connor, G., Ge, D., Fellay, J., Martin, J. N., Margolick, J., Goedert, J. J., et al. HLA-C cell surface expression and control of HIV/AIDS correlate with a variant upstream of HLA-C Nature Genetics  2009 41:1290-1294  DOI:10.1038/ng.486  PMID:19935663  PMCID:PMC2887091
    • Urban, T. J., Weintrob, A. C., Fellay, J., Colombo, S., Shianna, K. V., Gumbs, C., Rotger, M., Pelak, K., Dang, K. K., Detels, R., Martinson, J. J., O'Brien, S. J., et al. CCL3L1 and HIV/AIDS susceptibility Nature Medicine  2009 15:1110-1112  DOI:10.1038/nm1009-1110  PMID:19812560  PMCID:PMC2821825
    • di Iulio, J., Fayet, A., Arab-Alameddine, M., Rotger, M., Lubomirov, R., Cavassini, M., Furrer, H., Gunthard, H. F., Colombo, S., Csajka, C., Eap, C. B., Decosterd, L. A., et al. In vivo analysis of efavirenz metabolism in individuals with impaired CYP2A6 function Pharmacogenetics and Genomics  2009 19:300-309  DOI:10.1097/FPC.0b013e328328d577  PMID:19238117
    • Martin, O., Valsesia, A., Telenti, A., Xenarios, I., Stevenson, B. J. AssociationViewer: a scalable and integrated software tool for visualization of large-scale variation data in genomic context Bioinformatics  2009 25:662-663  DOI:10.1093/bioinformatics/btp017  PMID:19168913  PMCID:PMC2647839
    • Telenti, A. Safety concerns about CCR5 as an antiviral target Current Opinion in HIV and AIDS  2009 4:131-135  DOI:10.1097/COH.0b013e3283223d76  PMID:19339952
    • Kazadi, K., Loeuillet, C., Deutsch, S., Ciuffi, A., Munoz, M., Beckmann, J. S., Moradpour, D., Antonarakis, S. E., Telenti, A. Genomic determinants of the efficiency of internal ribosomal entry sites of viral and cellular origin Nucleic Acids Research  2008 36:6918-6925  DOI:10.1093/nar/gkn812  PMID:18978018  PMCID:PMC2588522
    • Fayet, A., Beguin, A., de Tejada, B. M., Colombo, S., Cavassini, M., Gerber, S., Eap, C. B., Telenti, A., Buclin, T., Biollaz, J., Decosterd, L. A. Determination of unbound antiretroviral drug concentrations by a modified ultrafiltration method reveals high variability in the free fraction Therapeutic Drug Monitoring  2008 30:511-522  PMID:18641538
    • Rauch, A., Nolan, D., Furrer, H., McKinnon, E., John, M., Mallal, S., Gaudieri, S., Gunthard, H. F., Schmid, P., Battegay, M., Hirschel, B., Telenti, A., et al. HLA-Bw4 homozygosity is associated with an impaired CD4 T cell recovery after initiation of antiretroviral therapy Clinical Infectious Diseases  2008 46:1921-1925  DOI:10.1086/588479  PMID:18466093
    • Rotger, M., Telenti, A. Optimizing efavirenz treatment: CYP2B6 genotyping or therapeutic drug monitoring? European Journal of Clinical Pharmacology  2008 64:335-336  DOI:10.1007/s00228-007-0440-z  PMID:18188549
    • Ge, D., Zhang, K., Need, A. C., Martin, O., Fellay, J., Urban, T. J., Telenti, A., Goldstein, D. B. WGAViewer: software for genomic annotation of whole genome association studies Genome Research  2008 18:640-643  DOI:10.1101/gr.071571.107  PMID:18256235  PMCID:PMC2279251
    • Loeuillet, C., Deutsch, S., Ciuffi, A., Robyr, D., Taffe, P., Munoz, M., Beckmann, J. S., Antonarakis, S. E., Telenti, A. In vitro whole-genome analysis identifies a susceptibility locus for HIV-1 PLoS Biology  2008 6:319-327  DOI:10.1371/journal.pbio.0060032  PMID:18288889  PMCID:PMC2245987
    • Colombo, S., Rauch, A., Rotger, M., Fellay, J., Martinez, R., Fux, C., Thurnheer, C., Gunthard, H. F., Goldstein, D. B., Furrer, H., Telenti, A. The HCP5 single-nucleotide polymorphism: a simple screening tool for prediction of hypersensitivity reaction to abacavir Journal of Infectious Diseases  2008 198:864-867  DOI:10.1086/591184  PMID:18684101
    • Telenti, A., Carrington, M. Host factors associated with outcome from primary human immunodeficiency virus-1 infection Current Opinion in HIV and AIDS  2008 3:28-35  DOI:10.1097/COH.0b013e3282f18ac0  PMID:19372941
    • Loeuillet, C., Weale, M., Deutsch, S., Rotger, M., Soranzo, N., Wyniger, J., Lettre, G., Dupre, Y., Thuillard, D., Beckmann, J. S., Antonarakis, S. E., Goldstein, D. B., et al. Promoter polymorphisms and allelic imbalance in ABCB1 expression Pharmacogenetics and Genomics  2007 17:951-959  DOI:10.1097/FPC.0b013e3282eff934  PMID:18075465
    • Rotger, M., Saumoy, M., Zhang, K. L., Flepp, M., Sahli, R., Decosterd, L., Telenti, A. Partial deletion of CYP2B6 owing to unequal crossover with CYP2B7 Pharmacogenetics and Genomics  2007 17:885-890  DOI:10.1097/FPC.0b013e3282ef5cd1  PMID:17885627
    • Von Wyl, V., Yerly, S., Boni, J., Burgisser, P., Klimkait, T., Battegay, M., Furrer, H., Telenti, A., Hirschel, B., Vernazza, P. L., Bernasconi, E., Rickenbach, M., et al. Emergence of HIV-1 drug resistance in previously untreated patients initiating combination antiretroviral treatment: a comparison of different regimen types Archives of Internal Medicine  2007 167:1782-1790  DOI:10.1001/archinte.167.16.1782  PMID:17846398
    • Arnedo, M., Taffe, P., Sahli, R., Furrer, H., Hirschel, B., Elzi, L., Weber, R., Vernazza, P., Bernasconi, E., Darioli, R., Bergmann, S., Beckmann, J. S., et al. Contribution of 20 single nucleotide polymorphisms of 13 genes to dyslipidemia associated with antiretroviral therapy Pharmacogenetics and Genomics  2007 17:755-764  DOI:10.1097/FPC.0b013e32814db8b7  PMID:17700364
    • Fellay, J., Shianna, K. V., Ge, D., Colombo, S., Ledergerber, B., Weale, M., Zhang, K., Gumbs, C., Castagna, A., Cossarizza, A., Cozzi-Lepri, A., De Luca, A., et al. A whole-genome association study of major determinants for host control of HIV-1 Science  2007 317:944-947  DOI:10.1126/science.1143767  PMID:17641165  PMCID:PMC1991296
    • Bochud, P. Y., Bochud, M., Telenti, A., Calandra, T. Innate immunogenetics: a tool for exploring new frontiers of host defence Lancet Infectious Diseases  2007 7:531-542  DOI:10.1016/s1473-3099(07)70185-8  PMID:17646026
    • Este, J. A., Telenti, A. HIV entry inhibitors Lancet  2007 370:81-88  DOI:10.1016/s0140-6736(07)61052-6  PMID:17617275
    • Lubomirov, R., Csajka, C., Telenti, A. ADME pathway approach for pharmacogenetic studies of anti-HIV therapy Pharmacogenomics  2007 8:623-633  DOI:10.2217/14622416.8.6.623  PMID:17559351
    • Martin, M. P., Qi, Y., Gao, X., Yamada, E., Martin, J. N., Pereyra, F., Colombo, S., Brown, E. E., Shupert, W. L., Phair, J., Goedert, J. J., Buchbinder, S., et al. Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1 Nature Genetics  2007 39:733-740  DOI:10.1038/ng2035  PMID:17496894  PMCID:PMC4135476
    • Zhang, K. L., Mangeat, B., Ortiz, M., Zoete, V., Trono, D., Telenti, A., Michielin, O. Model structure of human APOBEC3G PLoS One  2007 2  DOI:10.1371/journal.pone.0000378  PMID:17440614  PMCID:PMC1849894
    • Bochud, P. Y., Hersberger, M., Taffe, P., Bochud, M., Stein, C. M., Rodrigues, S. D., Calandra, T., Francioli, P., Telenti, A., Speck, R. F., Aderem, A. Polymorphisms in Toll-like receptor 9 influence the clinical course of HIV-1 infection AIDS  2007 21:441-446  DOI:10.1097/QAD.0b013e328012b8ac  PMID:17301562
    • Butticaz, C., Michielin, O., Wyniger, J., Telenti, A., Rothenberger, S. Silencing of both β-TrCP1 and HOS (β-TrCP2) is required to suppress human immunodeficiency virus type 1 Vpu-mediated CD4 down-modulation Journal of Virology  2007 81:1502-1505  DOI:10.1128/jvi.01711-06  PMID:17121803  PMCID:PMC1797504
    • Keiser, O., Fellay, J., Opravil, M., Hirsch, H. H., Hirschel, B., Bernasconi, E., Vernazza, P. L., Rickenbach, M., Telenti, A., Furrer, H. Adverse events to antiretrovirals in the Swiss HIV Cohort Study: Effect on mortality and treatment modification Antiviral Therapy  2007 12:1157-1164  PMID:18240856
    • Rotger, M., Colombo, S., Furrer, H., Decosterd, L., Buclin, T., Telenti, A. Does tenofovir influence efavirenz pharmacokinetics? Antiviral Therapy  2007 12:115-118  PMID:17503755
    • Telenti, A., Egger, M. Identifying safety concerns from genetic data: lessons from the development of CCR5 inhibitors Antiviral Therapy  2007 12:147-148  PMID:17503656
    • Gaudieri, S., Rauch, A., Park, L. P., Freitas, E., Herrmann, S., Jeffrey, G., Cheng, W., Pfafferott, K., Naidoo, K., Chapman, R., Battegay, M., Weber, R., et al. Evidence of viral adaptation to HLA class I-restricted immune pressure in chronic hepatitis C virus infection Journal of Virology  2006 80:11094-11104  DOI:10.1128/jvi.00912-06  PMID:17071929  PMCID:PMC1642167
    • Telenti, A., Goldstein, D. B. Genomics meets HIV-1 Nature Reviews Microbiology  2006 4:865-873  DOI:10.1038/nrmicro1532  PMID:17041633  PMCID:PMC2043131
    • Colombo, S., Buclin, T., Cavassini, M., Decosterd, L. A., Telenti, A., Biollaz, J., Csajka, C. Population pharmacokinetics of atazanavir in patients with human immunodeficiency virus infection Antimicrobial Agents and Chemotherapy  2006 50:3801-3808  DOI:10.1128/aac.00098-06  PMID:16940065  PMCID:PMC1635184
    • Colombo, S., Buclin, T., Decosterd, L. A., Telenti, A., Furrer, H., Lee, B. L., Biollaz, J., Eap, C. B. Orosomucoid (α1-acid glycoprotein) plasma concentration and genetic variants: Effects on human immunodeficiency virus protease inhibitor clearance and cellular accumulation Clinical Pharmacology & Therapeutics  2006 80:307-318  DOI:10.1016/j.clpt.2006.06.006  PMID:17015049
    • Goldschmidt, V., Bleiber, G., May, M., Martinez, R., Ortiz, M., Telenti, A. Role of common human TRIM5α variants in HIV-1 disease progression Retrovirology  2006 3  DOI:10.1186/1742-4690-3-54  PMID:16925802  PMCID:PMC1560158
    • Ariumi, Y., Serhan, F., Turelli, P., Telenti, A., Trono, D. The integrase interactor I (INII) proteins facilitate Tat-mediated human immunodeficiency virus type I transcription Retrovirology  2006 3  DOI:10.1186/1742-4690-3-47  PMID:16889668  PMCID:PMC1557532
    • Telenti, A. Host polymorphism in steps of the HIV-1 lifecycle after entry and other genetic variants influencing HIV-1 pathogenesis Current Opinion in HIV and AIDS  2006 1:232-240  DOI:10.1097/01.coh.0000221598.79906.12  PMID:19372815
    • Ortiz, M., Bleiber, G., Martinez, R., Kaessmann, H., Telenti, A. Patterns of evolution of host proteins involved in retroviral pathogenesis Retrovirology  2006 3  DOI:10.1186/1742-4690-3-11  PMID:16460575  PMCID:PMC1409793
    • Telenti, A., Bleiber, G. Host genetics of HIV-1 susceptibility Future Virology  2006 1:55-70  DOI:10.2217/17460794.1.1.55
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Background

education and training

  • Ph.D. in Microbial Genetics, University of Zaragoza, Spain 2000
  • University of Bern, Switzerland , Microbiology Fellowship 1994
  • Mayo Clinic , Mayo Graduate School, Infectious Diseases 1990
  • Mayo Clinic , Mayo Graduate School, Internal Medicine 1987
  • M.D., University of Oviedo, Spain 1982

credentials

  • American Board of Infectious Diseases, 1990
  • American Board of Internal Medicine, 1987

awards and honors

  • Elected member of the Swiss Academy of Medical Sciences , 2012
  • Swiss Society for Infectious Diseases Basic Research Award, 2008
  • Member of Honour, conferred by Royal Academy of Medicine of Asturias, Spain, 2005
  • Cloetta Award, conferred by Cloetta Foundation, 2004
  • European Society of Clinical Microbiology and Infectious Diseases Award for Research, 1997
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Contact

full name

  • Amalio Telenti
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Identity

eRA Commons ID

  • atelenti

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