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Teijaro, John R.
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Teijaro, John R.

Faculty Member
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Positions

  • 2017 - Assistant Professor, Immunology and Microbiology , Scripps Research
  • 2014 - Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
  • 2016 - 2017 Assistant Professor, Immunology and Microbial Science (IMS) , Scripps Research
  • 2014 - 2016 Assistant Professor of IMS, Immunology and Microbial Science (IMS) , Scripps Research
  • 2009 - 2014 Research Associate, Immunology and Microbial Science (IMS) , Scripps Research

Contact

  • teijaro@scripps.edu

Websites

  • John Teijaro, Ph.D.
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Publications

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  • academic article

    • Lang, F. M., Lee, K. M. C., Teijaro, J. R., Becher, B., Hamilton, J. A. GM-CSF-based treatments in COVID-19: reconciling opposing therapeutic approaches Nature Reviews Immunology  2020  DOI:10.1038/s41577-020-0357-7  PMID:32576980  PMCID:PMC7309428
    • Grodeland, G., Baranowska-Hustad, M., Abadejos, J., Blane, T. R., Teijaro, J., Nemazee, D., Bogen, B. Induction of cross-reactive and protective antibody responses after DNA vaccination with MHCII-targeted stem domain from influenza hemagglutinin Frontiers in Immunology  2020 11  DOI:10.3389/fimmu.2020.00431  PMID:32269566  PMCID:PMC7112135
    • Vinogradova, E. V., Zhang, X. Y., Remillard, D., Lazar, D. C., Suciu, R. M., Wang, Y. J., Bianco, G., Yamashita, Y., Crowley, V. M., Schafroth, M. A., Yokoyama, M., Konrad, D. B., et al. An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells Cell  2020 182:1009-1026  DOI:10.1016/j.cell.2020.07.001  PMID:32730809
    • Chin, E. N., Yu, C. G., Vartabedian, V. F., Jia, Y., Kumar, M., Gamo, A. M., Vernier, W., Ali, S. H., Kissai, M., Lazar, D. C., Nguyen, N., Pereira, L. E., et al. Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic Science  2020 369:993-999  DOI:10.1126/science.abb4255  PMID:32820126
    • Liu, Z., Li, J. P., Chen, M., Wu, M., Shi, Y., Li, W., Teijaro, J. R., Wu, P. Detecting Tumor Antigen-Specific T Cells via Interaction-Dependent Fucosyl-Biotinylation Cell  2020 183:1117-1133  DOI:10.1016/j.cell.2020.09.048  PMID:33096019  PMCID:PMC7669731
    • Rogers, T. F., Zhao, F., Huang, D. L., Beutler, N., Burns, A., He, W. T., Limbo, O., Smith, C., Song, G., Woehl, J., Yang, L. L., Abbott, R. K., et al. Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model Science  2020 369:956-963  DOI:10.1126/science.abc7520  PMID:32540903  PMCID:PMC7299280
    • Marro, B. S., Zak, J., Zavareh, R. B., Teijaro, J. R., Lairson, L. L., Oldstone, M. B. A. Discovery of small molecules for the reversal of T cell exhaustion Cell Reports  2019 29:3293-3302  DOI:10.1016/j.celrep.2019.10.119  PMID:31801090  PMCID:PMC6931400
    • Huang, Z., Zak, J., Pratumchai, I., Shaabani, N., Vartabedian, V. F., Nguyen, N., Wu, T., Xiao, C., Teijaro, J. R. IL-27 promotes the expansion of self-renewing CD8+ T cells in persistent viral infection Journal of Experimental Medicine  2019 216:1791-1808  DOI:10.1084/jem.20190173  PMID:31164392  PMCID:PMC6683984
    • Zaro, B. W., Vinogradova, E. V., Lazar, D. C., Blewett, M. M., Suciu, R. M., Takaya, J., Studer, S., de la Torre, J. C., Casanova, J. L., Cravatt, B. F., Teijaro, J. R. Development of dimethyl fumarate disrupts human innate immune signaling by targeting the IRAK4-MyD88 complexa terpene feedstock-based oxidative synthetic approach to the illicium sesquiterpenes Journal of Immunology  2019 202:2737-2746  DOI:10.4049/jimmunol.1801627  PMID:30885957  PMCID:PMC6478521
    • de la Torre, J. C., Teijaro, J. Editorial overview: Viral immunology Current Opinion in Virology  2019 34:vii-viii  DOI:10.1016/j.coviro.2019.03.003  PMID:31006423
    • Ogasawara, D., Ichu, T. A., Vartabedian, V. F., Benthuysen, J., Jing, H., Reed, A., Ulanovskaya, O. A., Hulce, J. J., Roberts, A., Brown, S., Rosen, H., Teijaro, J. R., et al. Selective blockade of the lyso-PS lipase ABHD12 stimulates immune responses in vivo Nature Chemical Biology  2018 14:1099-1108  DOI:10.1038/s41589-018-0155-8  PMID:30420694  PMCID:PMC6263940
    • Gavin, A. L., Huang, D., Huber, C., Martensson, A., Tardif, V., Skog, P. D., Blane, T. R., Thinnes, T. C., Osborn, K., Chong, H. S., Kargaran, F., Kimm, P., et al. PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing Nature Immunology  2018 19:942-953  DOI:10.1038/s41590-018-0179-y  PMID:30111894  PMCID:PMC6105523
    • Shaabani, N., Honke, N., Nguyen, N., Huang, Z., Arimoto, K. I., Lazar, D., Loe, T. K., Lang, K. S., Prinz, M., Knobeloch, K. P., Zhang, D. E., Teijaro, J. R. The probacterial effect of type I interferon signaling requires its own negative regulator USP18 Science Immunology  2018 3  DOI:10.1126/sciimmunol.aau2125  PMID:30266866
    • Teijaro, J. R., Burton, D. R. Taking down defenses to improve vaccines Science  2018 359:277-278  DOI:10.1126/science.aar5421  PMID:29348225
    • Smelkinson, M. G., Guichard, A., Teijaro, J. R., Malur, M., Loureiro, M. E., Jain, P., Ganesan, S., Zuniga, E. I., Krug, R. M., Oldstone, M. B., Bier, E. Influenza NS1 directly modulates Hedgehog signaling during infection PLoS Pathogens  2017 13  DOI:10.1371/journal.ppat.1006588  PMID:28837667
    • Teijaro, J. R. Cytokine storms in infectious diseases Seminars in Immunopathology  2017 39:501-503  DOI:10.1007/s00281-017-0640-2  PMID:28674818
    • Warth, B., Levin, N., Rinehart, D., Teijaro, J., Benton, H. P., Siuzdak, G. Metabolizing data in the cloud Trends in Biotechnology  2017 35:481-483  DOI:10.1016/j.tibtech.2016.12.010  PMID:28117091
    • Honke, N., Shaabani, N., Teijaro, J. R., Christen, U., Hardt, C., Bezgovsek, J., Lang, P. A., Lang, K. S. Presentation of autoantigen in peripheral lymph nodes is sufficient for priming autoreactive CD8(+) T cells Frontiers in Immunology  2017 8  DOI:10.3389/fimmu.2017.00113  PMID:28239381  PMCID:PMC5301005
    • Maine, C. J., Teijaro, J. R., Marquardt, K., Sherman, L. A. PTPN22 contributes to exhaustion of T lymphocytes during chronic viral infection Proceedings of the National Academy of Sciences of the United States of America  2016 113:E7231-E7239  DOI:10.1073/pnas.1603738113  PMID:27799548  PMCID:PMC5135306
    • Wang, R. S. E., Wang, Y., Zhang, Y., Gabrelow, C., Zhang, Y., Chi, V., Fu, Q., Luo, X., Wang, D., Joseph, S., Johnson, K., Chatterjee, A. K., et al. Rational design of a Kv1.3 channel-blocking antibody as a selective immunosuppressant Proceedings of the National Academy of Sciences of the United States of America  2016 113:11501-11506  DOI:10.1073/pnas.1612803113  PMID:27663736  PMCID:PMC5068325
    • Blewett, M. M., Xie, J., Zaro, B. W., Backus, K. M., Altman, A., Teijaro, J. R., Cravatt, B. F. Chemical proteomic map of dimethyl fumarate-sensitive cysteines in primary human T cells Science Signaling  2016 9  DOI:10.1126/scisignal.aaf7694  PMID:27625306  PMCID:PMC5068918
    • Cravatt, B. F., Blewett, M. M., Teijaro, J. R., VanHook, A. M. Science Signaling Podcast for 13 September 2016: DMF and the immune system Science Signaling  2016 9  DOI:10.1126/scisignal.aai8956
    • Barnett, B. E., Staupe, R. P., Odorizzi, P. M., Palko, O., Tomov, V. T., Mahan, A. E., Gunn, B., Chen, D., Paley, M. A., Alter, G., Reiner, S. L., Lauer, G. M., et al. Cutting edge: B cell-intrinsic T-bet expression is required to control chronic viral infection Journal of Immunology  2016 197:1017-1022  DOI:10.4049/jimmunol.1500368  PMID:27430722  PMCID:PMC4975981
    • Backus, K. M., Correia, B. E., Lum, K. M., Forli, S., Horning, B. D., Gonzalez-Paez, G. E., Chatterjee, S., Lanning, B. R., Teijaro, J. R., Olson, A. J., Wolan, D. W., Cravatt, B. F. Proteome-wide covalent ligand discovery in native biological systems Nature  2016 534:570-574  DOI:10.1038/nature18002  PMID:27309814  PMCID:PMC4919207
    • Teijaro, J. R., Studer, S., Leaf, N., Kiosses, W. B., Nguyen, N., Matsuki, K., Negishi, H., Taniguchi, T., Oldstone, M. B. A., Rosen, H. S1PR1-mediated IFNAR1 degradation modulates plasmacytoid dendritic cell interferon-alpha autoamplification Proceedings of the National Academy of Sciences of the United States of America  2016 113:1351-1356  DOI:10.1073/pnas.1525356113  PMID:26787880  PMCID:PMC4747766
    • Teijaro, J. R. Too much of a good thing: Sustained type 1 interferon signaling limits humoral responses to secondary viral infection European Journal of Immunology  2016 46:300-302  DOI:10.1002/eji.201546224  PMID:26783074
    • Teijaro, J. R. Type I interferons in viral control and immune regulation Current Opinion in Virology  2016 16:31-40  DOI:10.1016/j.coviro.2016.01.001  PMID:26812607  PMCID:PMC4821698
    • Teijaro, J. R. Pleiotropic roles of type 1 interferons in antiviral immune responses Advances in Immunology  2016 132:135-158  DOI:10.1016/bs.ai.2016.08.001  PMID:27769506
    • Iwasaki, M., Ngo, N., Cubitt, B., Teijaro, J. R., de la Torre, J. C. General molecular strategy for development of arenavirus live-attenuated vaccines Journal of Virology  2015 89:12166-12177  DOI:10.1128/jvi.02075-15  PMID:26401045  PMCID:PMC4645318
    • Ng, C. T., Sullivan, B. M., Teijaro, J. R., Lee, A. M., Welch, M., Rice, S., Sheehan, K. C. F., Schreiber, R. D., Oldstone, M. B. A. Blockade of interferon Beta, but not interferon alpha, signaling controls persistent viral infection Cell Host & Microbe  2015 17:653-661  DOI:10.1016/j.chom.2015.04.005  PMID:25974304  PMCID:PMC4432251
    • Sullivan, B. M., Teijaro, J. R., de la Torre, J. C., Oldstone, M. B. A. Early virus-host interactions dictate the course of a persistent infection PLoS Pathogens  2015 11  DOI:10.1371/journal.ppat.1004588  PMID:25569216  PMCID:PMC4287607
    • Teijaro, J. R. The role of cytokine responses during influenza virus pathogenesis and potential therapeutic options Current Topics in Microbiology and Immunology  2015 386:3-22  DOI:10.1007/82_2014_411  PMID:25267464
    • Baccala, R., Welch, M. J., Gonzalez-Quintial, R., Walsh, K. B., Teijaro, J. R., Nguyen, A., Ng, C. T., Sullivan, B. M., Zarpellon, A., Ruggeri, Z. M., de la Torre, J. C., Theofilopoulos, A. N., et al. Type I interferon is a therapeutic target for virus-induced lethal vascular damage Proceedings of the National Academy of Sciences of the United States of America  2014 111:8925-8930  DOI:10.1073/pnas.1408148111  PMID:24889626  PMCID:PMC4066519
    • Walsh, K. B., Teijaro, J. R., Brock, L. G., Fremgen, D. M., Collins, P. L., Rosen, H., Oldstone, M. B. A. Animal model of respiratory syncytial virus: CD8(+) T cells cause a cytokine storm that is chemically tractable by sphingosine-1-phosphate 1 receptor agonist therapy Journal of Virology  2014 88:6281-6293  DOI:10.1128/jvi.00464-14  PMID:24672024
    • Teijaro, J. R., Walsh, K. B., Rice, S., Rosen, H., Oldstone, M. B. A. Mapping the innate signaling cascade essential for cytokine storm during influenza virus infection Proceedings of the National Academy of Sciences of the United States of America  2014 111:3799-3804  DOI:10.1073/pnas.1400593111  PMID:24572573  PMCID:PMC3956176
    • Teijaro, J. R., Walsh, K. B., Long, J. P., Tordoff, K. P., Stark, G. V., Eisfeld, A. J., Kawaoka, Y., Rosen, H., Oldstone, M. B. A. Protection of ferrets from pulmonary injury due to H1N1 2009 influenza virus infection: immunopathology tractable by sphingosine-1-phosphate 1 receptor agonist therapy Virology  2014 452:152-157  DOI:10.1016/j.virol.2014.01.003  PMID:24606692  PMCID:PMC3954990
    • Kang, S. G., Liu, W. H., Lu, P., Jin, H. Y., Lim, H. W., Shepherd, J., Fremgen, D., Verdin, E., Oldstone, M. B. A., Qi, H., Teijaro, J. R., Xiao, C. MicroRNAs of the miR-17 similar to 92 family are critical regulators of T-FH differentiation Nature Immunology  2013 14:849-857  DOI:10.1038/ni.2648  PMID:23812097  PMCID:PMC3740954
    • Teijaro, J. R., Ng, C., Lee, A. M., Sullivan, B. M., Sheehan, K. C. F., Welch, M., Schreiber, R. D., de la Torre, J. C., Oldstone, M. B. A. Persistent LCMV infection is controlled by blockade of type I interferon signaling Science  2013 340:207-211  DOI:10.1126/science.1235214  PMID:23580529  PMCID:PMC3640797
    • Matheu, M. P., Teijaro, J. R., Walsh, K. B., Greenberg, M. L., Marsolais, D., Parker, I., Rosen, H., Oldstone, M. B. A., Cahalan, M. D. Three phases of CD8 T cell response in the lung following H1N1 influenza infection and sphingosine 1 phosphate agonist therapy PLoS One  2013 8:e58033  DOI:10.1371/journal.pone.0058033  PMID:23533579  PMCID:PMC3606384
    • Oldstone, M. B. A., Teijaro, J. R., Walsh, K. B., Rosen, H. Dissecting influenza virus pathogenesis uncovers a novel chemical approach to combat the infection Virology  2013 435:92-101  DOI:10.1016/j.virol.2012.09.039  PMID:23217619  PMCID:PMC3523270
    • Welch, M. J., Teijaro, J. R., Lewicki, H. A., Colonna, M., Oldstone, M. B. A. CD8 T cell defect of TNF-α and IL-2 in DNAM-1 deficient mice delays clearance in vivo of a persistent virus infection. Virology  2012 429:163-170  DOI:10.1016/j.virol.2012.04.006  PMID:22579352  PMCID:PMC3571684
    • Walsh, K. B., Teijaro, J. R., Zuniga, E. I., Welch, M. J., Fremgen, D. M., Blackburn, S. D., von Tiehl, K. F., Wherry, E. J., Flavell, R. A., Oldstone, M. B. A. Toll-like receptor 7 is required for effective adaptive immune responses that prevent persistent virus infection Cell Host & Microbe  2012 11:643-653  DOI:10.1016/j.chom.2012.04.016  PMID:22704624  PMCID:PMC3377981
    • Teijaro, J. R., Turner, D., Pham, Q., Wherry, E. J., Lefrancois, L., Farber, D. L. Cutting edge: Tissue-retentive lung memory CD4 T cells mediate optimal protection to respiratory virus infection Journal of Immunology  2011 187:5510-5514  DOI:10.4049/jimmunol.1102243  PMID:22058417  PMCID:PMC3221837
    • Walsh, K. B., Teijaro, J. R., Rosen, H., Oldstone, M. B. A. Quelling the storm: Utilization of sphingosine-1-phosphate receptor signaling to ameliorate influenza virus-induced cytokine storm Immunologic Research  2011 51:15-25  DOI:10.1007/s12026-011-8240-z  PMID:21901448
    • Teijaro, J. R., Walsh, K. B., Cahalan, S., Fremgen, D. M., Roberts, E., Scott, F., Martinborough, E., Peach, R., Oldstone, M. B. A., Rosen, H. Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection Cell  2011 146:979-990  DOI:10.1016/j.cell.2011.08.015  PMID:21925319  PMCID:PMC3176439
    • Popkin, D. L., Teijaro, J. R., Lee, A. M., Lewicki, H., Emonet, S., de la Torre, J. C., Oldstone, M. Expanded potential for recombinant trisegmented lymphocytic choriomeningitis viruses: Protein production, antibody production, and in vivo assessment of biological function of genes of interest Journal of Virology  2011 85:7928-7932  DOI:10.1128/jvi.00486-11  PMID:21613399  PMCID:PMC3147893
    • Walsh, K. B., Teijaro, J. R., Wilker, P. R., Jatzek, A., Fremgen, D. M., Das, S. C., Watanabe, T., Hatta, M., Shinya, K., Suresh, M., Kawaoka, Y., Rosen, H., et al. Suppression of cytokine storm with a sphingosine analog provides protection against pathogenic influenza virus Proceedings of the National Academy of Sciences of the United States of America  2011 108:12018-12023  DOI:10.1073/pnas.1107024108  PMID:21715659  PMCID:PMC3142000
    • Hemmers, S., Teijaro, J. R., Arandjelovic, S., Mowen, K. A. PAD4-mediated neutrophil extracellular trap formation is not required for immunity against influenza infection PLoS One  2011 6:e22043  DOI:10.1371/journal.pone.0022043  PMID:21779371  PMCID:PMC3133614
    • Ayala, V. I., Teijaro, J. R., Farber, D. L., Dorsey, S. G., Carbonetti, N. H. Bordetella pertussis infection exacerbates influenza virus infection through pertussis toxin-mediated suppression of innate immunity PLoS One  2011 6:e19016  DOI:10.1371/journal.pone.0019016  PMID:21533103  PMCID:PMC3080395
    • Popkin, D. L., Teijaro, J. R., Sullivan, B. M., Urata, S., Rutschmann, S., de la Torre, J. C., Kunz, S., Beutler, B., Oldstone, M. Hypomorphic mutation in the site-1 protease Mbtps1 endows resistance to persistent viral infection in a cell-specific manner Cell Host & Microbe  2011 9:212-222  DOI:10.1016/j.chom.2011.02.006  PMID:21402360  PMCID:PMC3058147
    • Shirey, K. A., Nhu, Q. M., Yim, K. C., Roberts, Z. J., Teijaro, J. R., Farber, D. L., Blanco, J. C., Vogel, S. N. The anti-tumor agent, 5,6-dimethylxanthenone-4-acetic acid (DMXAA), induces IFN-beta-mediated antiviral activity in vitro and in vivo Journal of Leukocyte Biology  2011 89:351-357  DOI:10.1189/jlb.0410216  PMID:21084628  PMCID:PMC3040469
    • Teijaro, J. R., Verhoeven, D., Page, C. A., Turner, D., Farber, D. L. Memory CD4 T cells direct protective responses to influenza virus in the lungs through helper-independent mechanisms Journal of Virology  2010 84:9217-9226  DOI:10.1128/jvi.01069-10  PMID:20592069  PMCID:PMC2937635
    • Nhu, Q. M., Shirey, K., Teijaro, J. R., Farber, D. L., Netzel-Arnett, S., Antalis, T. M., Fasano, A., Vogel, S. N. Novel signaling interactions between proteinase-activated receptor 2 and Toll-like receptors in vitro and in vivo Mucosal Immunol  2010 3:29-39  DOI:10.1038/mi.2009.120  PMID:19865078  PMCID:PMC2851245
    • Chandran, S. S., Verhoeven, D., Teijaro, J. R., Fenton, M. J., Farber, D. L. TLR2 engagement on dendritic cells promotes high frequency effector and memory CD4 T cell responses Journal of Immunology  2009 183:7832-7841  DOI:10.4049/jimmunol.0901683  PMID:19933854
    • Verhoeven, D., Teijaro, J. R., Farber, D. L. Pulse-oximetry accurately predicts lung pathology and the immune response during influenza infection Virology  2009 390:151-156  DOI:10.1016/j.virol.2009.05.004  PMID:19493556  PMCID:PMC2776688
    • Teijaro, J. R., Njau, M. N., Verhoeven, D., Chandran, S., Nadler, S. G., Hasday, J., Farber, D. L. Costimulation modulation uncouples protection from immunopathology in memory T cell responses to influenza virus Journal of Immunology  2009 182:6834-6843  DOI:10.4049/jimmunol.0803860  PMID:19454679
    • Tang, A. L., Teijaro, J. R., Njau, M. N., Chandran, S. S., Azimzadeh, A., Nadler, S. G., Rothstein, D. M., Farber, D. L. CTLA4 expression is an indicator and regulator of steady-state CD4(+)FoxP3(+) T cell homeostasis Journal of Immunology  2008 181:1806-1813  DOI:10.4049/jimmunol.181.3.1806  PMID:18641318  PMCID:PMC2683757
    • Casares, S., Lin, M., Zhang, N., Teijaro, J. R., Stoica, C., McEvoy, R., Farber, D. L., Bona, C., Brumeanu, T. D. A peptide-major histocompatibility complex II chimera favors survival of pancreatic beta-islets grafted in type 1 diabetic mice Transplantation  2008 85:1717-1725  DOI:10.1097/TP.0b013e31817752cc  PMID:18580462
    • Verhoeven, D., Teijaro, J. R., Farber, D. L. Heterogeneous memory T cells in antiviral immunity and immunopathology Viral Immunology  2008 21:99-113  DOI:10.1089/vim.2007.0002  PMID:18476772  PMCID:PMC2996251
    • Ndejembi, M. P., Teijaro, J. R., Patke, D. S., Bingaman, A. W., Chandok, M. R., Azimzadeh, A., Nadler, S. G., Farber, D. L. Control of memory CD4 T cell recall by the CD28/B7 costimulatory pathway Journal of Immunology  2006 177:7698-7706  DOI:10.4049/jimmunol.177.11.7698  PMID:17114440
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Teaching

advisees

  • graduate advising relationship

    • Gazaniga, Nathalia Romanio, Ph.D.  candidate, 2019 -
    • Keating, Celina Louise, Ph.D.  candidate, 2019 -
    • Lazar, Daniel, Ph.D.  candidate, 2018 -
    • Vartabedian, Vincent, Ph.D.  candidate, 2016 -
    • Zak, Jerry, Ph.D.  candidate, 2012 - 2017
  • postdoc or fellow advising relationship

    • Zak, Jerry, Ph.D.  candidate, 2017 -
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Background

education and training

  • Ph.D. in Microbiology and Immunology, University of Maryland, Baltimore , School of Medicine 2004 - 2009
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Contact

full name

  • John R. Teijaro

geographic location

  • Scripps California 

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