recent publications
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academic article
- Teijaro, J. R., Farber, D. L. COVID-19 vaccines: modes of immune activation and future challenges Nature Reviews Immunology 2021 21:195-197 DOI:10.1038/s41577-021-00526-x PMID:33674759 PMCID:PMC7934118
- Huang, Z., Kang, S. G., Li, Y. Q., Zak, J., Shaabani, N., Deng, K. Y., Shepherd, J., Bhargava, R., Teijaro, J. R., Xiao, C. IFNAR1 signaling in NK cells promotes persistent virus infection Science Advances 2021 7 DOI:10.1126/sciadv.abb8087 PMID:33771858 PMCID:PMC7997497
- Han, Z., Thuy-Boun, P. S., Pfeiffer, W., Vartabedian, V. F., Torkamani, A., Teijaro, J. R., Wolan, D. W. Identification of an N-acetylneuraminic acid-presenting bacteria isolated from a human microbiome Scientific Reports 2021 11 DOI:10.1038/s41598-021-83875-w PMID:33637779 PMCID:PMC7910532
- Lang, F. M., Lee, K. M. C., Teijaro, J. R., Becher, B., Hamilton, J. A. GM-CSF-based treatments in COVID-19: reconciling opposing therapeutic approaches Nature Reviews Immunology 2020 DOI:10.1038/s41577-020-0357-7 PMID:32576980 PMCID:PMC7309428
- Grodeland, G., Baranowska-Hustad, M., Abadejos, J., Blane, T. R., Teijaro, J., Nemazee, D., Bogen, B. Induction of cross-reactive and protective antibody responses after DNA vaccination with MHCII-targeted stem domain from influenza hemagglutinin Frontiers in Immunology 2020 11 DOI:10.3389/fimmu.2020.00431 PMID:32269566 PMCID:PMC7112135
- Vinogradova, E. V., Zhang, X. Y., Remillard, D., Lazar, D. C., Suciu, R. M., Wang, Y. J., Bianco, G., Yamashita, Y., Crowley, V. M., Schafroth, M. A., Yokoyama, M., Konrad, D. B., et al. An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells Cell 2020 182:1009-1026 DOI:10.1016/j.cell.2020.07.001 PMID:32730809
- Chin, E. N., Yu, C. G., Vartabedian, V. F., Jia, Y., Kumar, M., Gamo, A. M., Vernier, W., Ali, S. H., Kissai, M., Lazar, D. C., Nguyen, N., Pereira, L. E., et al. Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic Science 2020 369:993-999 DOI:10.1126/science.abb4255 PMID:32820126
- Liu, Z., Li, J. P., Chen, M., Wu, M., Shi, Y., Li, W., Teijaro, J. R., Wu, P. Detecting Tumor Antigen-Specific T Cells via Interaction-Dependent Fucosyl-Biotinylation Cell 2020 183:1117-1133 DOI:10.1016/j.cell.2020.09.048 PMID:33096019 PMCID:PMC7669731
- Rogers, T. F., Zhao, F., Huang, D. L., Beutler, N., Burns, A., He, W. T., Limbo, O., Smith, C., Song, G., Woehl, J., Yang, L. L., Abbott, R. K., et al. Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model Science 2020 369:956-963 DOI:10.1126/science.abc7520 PMID:32540903 PMCID:PMC7299280
- Marro, B. S., Zak, J., Zavareh, R. B., Teijaro, J. R., Lairson, L. L., Oldstone, M. B. A. Discovery of small molecules for the reversal of T cell exhaustion Cell Reports 2019 29:3293-3302 DOI:10.1016/j.celrep.2019.10.119 PMID:31801090 PMCID:PMC6931400
- Huang, Z., Zak, J., Pratumchai, I., Shaabani, N., Vartabedian, V. F., Nguyen, N., Wu, T., Xiao, C., Teijaro, J. R. IL-27 promotes the expansion of self-renewing CD8+ T cells in persistent viral infection Journal of Experimental Medicine 2019 216:1791-1808 DOI:10.1084/jem.20190173 PMID:31164392 PMCID:PMC6683984
- Zaro, B. W., Vinogradova, E. V., Lazar, D. C., Blewett, M. M., Suciu, R. M., Takaya, J., Studer, S., de la Torre, J. C., Casanova, J. L., Cravatt, B. F., Teijaro, J. R. Development of dimethyl fumarate disrupts human innate immune signaling by targeting the IRAK4-MyD88 complexa terpene feedstock-based oxidative synthetic approach to the illicium sesquiterpenes Journal of Immunology 2019 202:2737-2746 DOI:10.4049/jimmunol.1801627 PMID:30885957 PMCID:PMC6478521
- de la Torre, J. C., Teijaro, J. Editorial overview: Viral immunology Current Opinion in Virology 2019 34:vii-viii DOI:10.1016/j.coviro.2019.03.003 PMID:31006423
- Ogasawara, D., Ichu, T. A., Vartabedian, V. F., Benthuysen, J., Jing, H., Reed, A., Ulanovskaya, O. A., Hulce, J. J., Roberts, A., Brown, S., Rosen, H., Teijaro, J. R., et al. Selective blockade of the lyso-PS lipase ABHD12 stimulates immune responses in vivo Nature Chemical Biology 2018 14:1099-1108 DOI:10.1038/s41589-018-0155-8 PMID:30420694 PMCID:PMC6263940
- Gavin, A. L., Huang, D., Huber, C., Martensson, A., Tardif, V., Skog, P. D., Blane, T. R., Thinnes, T. C., Osborn, K., Chong, H. S., Kargaran, F., Kimm, P., et al. PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing Nature Immunology 2018 19:942-953 DOI:10.1038/s41590-018-0179-y PMID:30111894 PMCID:PMC6105523
- Shaabani, N., Honke, N., Nguyen, N., Huang, Z., Arimoto, K. I., Lazar, D., Loe, T. K., Lang, K. S., Prinz, M., Knobeloch, K. P., Zhang, D. E., Teijaro, J. R. The probacterial effect of type I interferon signaling requires its own negative regulator USP18 Science Immunology 2018 3 DOI:10.1126/sciimmunol.aau2125 PMID:30266866
- Teijaro, J. R., Burton, D. R. Taking down defenses to improve vaccines Science 2018 359:277-278 DOI:10.1126/science.aar5421 PMID:29348225
- Smelkinson, M. G., Guichard, A., Teijaro, J. R., Malur, M., Loureiro, M. E., Jain, P., Ganesan, S., Zuniga, E. I., Krug, R. M., Oldstone, M. B., Bier, E. Influenza NS1 directly modulates Hedgehog signaling during infection PLoS Pathogens 2017 13 DOI:10.1371/journal.ppat.1006588 PMID:28837667
- Teijaro, J. R. Cytokine storms in infectious diseases Seminars in Immunopathology 2017 39:501-503 DOI:10.1007/s00281-017-0640-2 PMID:28674818
- Warth, B., Levin, N., Rinehart, D., Teijaro, J., Benton, H. P., Siuzdak, G. Metabolizing data in the cloud Trends in Biotechnology 2017 35:481-483 DOI:10.1016/j.tibtech.2016.12.010 PMID:28117091
- Honke, N., Shaabani, N., Teijaro, J. R., Christen, U., Hardt, C., Bezgovsek, J., Lang, P. A., Lang, K. S. Presentation of autoantigen in peripheral lymph nodes is sufficient for priming autoreactive CD8(+) T cells Frontiers in Immunology 2017 8 DOI:10.3389/fimmu.2017.00113 PMID:28239381 PMCID:PMC5301005
- Maine, C. J., Teijaro, J. R., Marquardt, K., Sherman, L. A. PTPN22 contributes to exhaustion of T lymphocytes during chronic viral infection Proceedings of the National Academy of Sciences of the United States of America 2016 113:E7231-E7239 DOI:10.1073/pnas.1603738113 PMID:27799548 PMCID:PMC5135306
- Wang, R. S. E., Wang, Y., Zhang, Y., Gabrelow, C., Zhang, Y., Chi, V., Fu, Q., Luo, X., Wang, D., Joseph, S., Johnson, K., Chatterjee, A. K., et al. Rational design of a Kv1.3 channel-blocking antibody as a selective immunosuppressant Proceedings of the National Academy of Sciences of the United States of America 2016 113:11501-11506 DOI:10.1073/pnas.1612803113 PMID:27663736 PMCID:PMC5068325
- Blewett, M. M., Xie, J., Zaro, B. W., Backus, K. M., Altman, A., Teijaro, J. R., Cravatt, B. F. Chemical proteomic map of dimethyl fumarate-sensitive cysteines in primary human T cells Science Signaling 2016 9 DOI:10.1126/scisignal.aaf7694 PMID:27625306 PMCID:PMC5068918
- Cravatt, B. F., Blewett, M. M., Teijaro, J. R., VanHook, A. M. Science Signaling Podcast for 13 September 2016: DMF and the immune system Science Signaling 2016 9 DOI:10.1126/scisignal.aai8956
- Barnett, B. E., Staupe, R. P., Odorizzi, P. M., Palko, O., Tomov, V. T., Mahan, A. E., Gunn, B., Chen, D., Paley, M. A., Alter, G., Reiner, S. L., Lauer, G. M., et al. Cutting edge: B cell-intrinsic T-bet expression is required to control chronic viral infection Journal of Immunology 2016 197:1017-1022 DOI:10.4049/jimmunol.1500368 PMID:27430722 PMCID:PMC4975981
- Backus, K. M., Correia, B. E., Lum, K. M., Forli, S., Horning, B. D., Gonzalez-Paez, G. E., Chatterjee, S., Lanning, B. R., Teijaro, J. R., Olson, A. J., Wolan, D. W., Cravatt, B. F. Proteome-wide covalent ligand discovery in native biological systems Nature 2016 534:570-574 DOI:10.1038/nature18002 PMID:27309814 PMCID:PMC4919207
- Teijaro, J. R., Studer, S., Leaf, N., Kiosses, W. B., Nguyen, N., Matsuki, K., Negishi, H., Taniguchi, T., Oldstone, M. B. A., Rosen, H. S1PR1-mediated IFNAR1 degradation modulates plasmacytoid dendritic cell interferon-alpha autoamplification Proceedings of the National Academy of Sciences of the United States of America 2016 113:1351-1356 DOI:10.1073/pnas.1525356113 PMID:26787880 PMCID:PMC4747766
- Teijaro, J. R. Too much of a good thing: Sustained type 1 interferon signaling limits humoral responses to secondary viral infection European Journal of Immunology 2016 46:300-302 DOI:10.1002/eji.201546224 PMID:26783074
- Teijaro, J. R. Type I interferons in viral control and immune regulation Current Opinion in Virology 2016 16:31-40 DOI:10.1016/j.coviro.2016.01.001 PMID:26812607 PMCID:PMC4821698
- Teijaro, J. R. Pleiotropic roles of type 1 interferons in antiviral immune responses Advances in Immunology 2016 132:135-158 DOI:10.1016/bs.ai.2016.08.001 PMID:27769506
- Iwasaki, M., Ngo, N., Cubitt, B., Teijaro, J. R., de la Torre, J. C. General molecular strategy for development of arenavirus live-attenuated vaccines Journal of Virology 2015 89:12166-12177 DOI:10.1128/jvi.02075-15 PMID:26401045 PMCID:PMC4645318
- Ng, C. T., Sullivan, B. M., Teijaro, J. R., Lee, A. M., Welch, M., Rice, S., Sheehan, K. C. F., Schreiber, R. D., Oldstone, M. B. A. Blockade of interferon Beta, but not interferon alpha, signaling controls persistent viral infection Cell Host & Microbe 2015 17:653-661 DOI:10.1016/j.chom.2015.04.005 PMID:25974304 PMCID:PMC4432251
- Sullivan, B. M., Teijaro, J. R., de la Torre, J. C., Oldstone, M. B. A. Early virus-host interactions dictate the course of a persistent infection PLoS Pathogens 2015 11 DOI:10.1371/journal.ppat.1004588 PMID:25569216 PMCID:PMC4287607
- Teijaro, J. R. The role of cytokine responses during influenza virus pathogenesis and potential therapeutic options Current Topics in Microbiology and Immunology 2015 386:3-22 DOI:10.1007/82_2014_411 PMID:25267464
- Baccala, R., Welch, M. J., Gonzalez-Quintial, R., Walsh, K. B., Teijaro, J. R., Nguyen, A., Ng, C. T., Sullivan, B. M., Zarpellon, A., Ruggeri, Z. M., de la Torre, J. C., Theofilopoulos, A. N., et al. Type I interferon is a therapeutic target for virus-induced lethal vascular damage Proceedings of the National Academy of Sciences of the United States of America 2014 111:8925-8930 DOI:10.1073/pnas.1408148111 PMID:24889626 PMCID:PMC4066519
- Walsh, K. B., Teijaro, J. R., Brock, L. G., Fremgen, D. M., Collins, P. L., Rosen, H., Oldstone, M. B. A. Animal model of respiratory syncytial virus: CD8(+) T cells cause a cytokine storm that is chemically tractable by sphingosine-1-phosphate 1 receptor agonist therapy Journal of Virology 2014 88:6281-6293 DOI:10.1128/jvi.00464-14 PMID:24672024
- Teijaro, J. R., Walsh, K. B., Rice, S., Rosen, H., Oldstone, M. B. A. Mapping the innate signaling cascade essential for cytokine storm during influenza virus infection Proceedings of the National Academy of Sciences of the United States of America 2014 111:3799-3804 DOI:10.1073/pnas.1400593111 PMID:24572573 PMCID:PMC3956176
- Teijaro, J. R., Walsh, K. B., Long, J. P., Tordoff, K. P., Stark, G. V., Eisfeld, A. J., Kawaoka, Y., Rosen, H., Oldstone, M. B. A. Protection of ferrets from pulmonary injury due to H1N1 2009 influenza virus infection: immunopathology tractable by sphingosine-1-phosphate 1 receptor agonist therapy Virology 2014 452:152-157 DOI:10.1016/j.virol.2014.01.003 PMID:24606692 PMCID:PMC3954990
- Kang, S. G., Liu, W. H., Lu, P., Jin, H. Y., Lim, H. W., Shepherd, J., Fremgen, D., Verdin, E., Oldstone, M. B. A., Qi, H., Teijaro, J. R., Xiao, C. MicroRNAs of the miR-17 similar to 92 family are critical regulators of T-FH differentiation Nature Immunology 2013 14:849-857 DOI:10.1038/ni.2648 PMID:23812097 PMCID:PMC3740954
- Teijaro, J. R., Ng, C., Lee, A. M., Sullivan, B. M., Sheehan, K. C. F., Welch, M., Schreiber, R. D., de la Torre, J. C., Oldstone, M. B. A. Persistent LCMV infection is controlled by blockade of type I interferon signaling Science 2013 340:207-211 DOI:10.1126/science.1235214 PMID:23580529 PMCID:PMC3640797
- Matheu, M. P., Teijaro, J. R., Walsh, K. B., Greenberg, M. L., Marsolais, D., Parker, I., Rosen, H., Oldstone, M. B. A., Cahalan, M. D. Three phases of CD8 T cell response in the lung following H1N1 influenza infection and sphingosine 1 phosphate agonist therapy PLoS One 2013 8:e58033 DOI:10.1371/journal.pone.0058033 PMID:23533579 PMCID:PMC3606384
- Oldstone, M. B. A., Teijaro, J. R., Walsh, K. B., Rosen, H. Dissecting influenza virus pathogenesis uncovers a novel chemical approach to combat the infection Virology 2013 435:92-101 DOI:10.1016/j.virol.2012.09.039 PMID:23217619 PMCID:PMC3523270
- Welch, M. J., Teijaro, J. R., Lewicki, H. A., Colonna, M., Oldstone, M. B. A. CD8 T cell defect of TNF-α and IL-2 in DNAM-1 deficient mice delays clearance in vivo of a persistent virus infection. Virology 2012 429:163-170 DOI:10.1016/j.virol.2012.04.006 PMID:22579352 PMCID:PMC3571684
- Walsh, K. B., Teijaro, J. R., Zuniga, E. I., Welch, M. J., Fremgen, D. M., Blackburn, S. D., von Tiehl, K. F., Wherry, E. J., Flavell, R. A., Oldstone, M. B. A. Toll-like receptor 7 is required for effective adaptive immune responses that prevent persistent virus infection Cell Host & Microbe 2012 11:643-653 DOI:10.1016/j.chom.2012.04.016 PMID:22704624 PMCID:PMC3377981
- Teijaro, J. R., Turner, D., Pham, Q., Wherry, E. J., Lefrancois, L., Farber, D. L. Cutting edge: Tissue-retentive lung memory CD4 T cells mediate optimal protection to respiratory virus infection Journal of Immunology 2011 187:5510-5514 DOI:10.4049/jimmunol.1102243 PMID:22058417 PMCID:PMC3221837
- Walsh, K. B., Teijaro, J. R., Rosen, H., Oldstone, M. B. A. Quelling the storm: Utilization of sphingosine-1-phosphate receptor signaling to ameliorate influenza virus-induced cytokine storm Immunologic Research 2011 51:15-25 DOI:10.1007/s12026-011-8240-z PMID:21901448
- Teijaro, J. R., Walsh, K. B., Cahalan, S., Fremgen, D. M., Roberts, E., Scott, F., Martinborough, E., Peach, R., Oldstone, M. B. A., Rosen, H. Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection Cell 2011 146:979-990 DOI:10.1016/j.cell.2011.08.015 PMID:21925319 PMCID:PMC3176439
- Popkin, D. L., Teijaro, J. R., Lee, A. M., Lewicki, H., Emonet, S., de la Torre, J. C., Oldstone, M. Expanded potential for recombinant trisegmented lymphocytic choriomeningitis viruses: Protein production, antibody production, and in vivo assessment of biological function of genes of interest Journal of Virology 2011 85:7928-7932 DOI:10.1128/jvi.00486-11 PMID:21613399 PMCID:PMC3147893
- Walsh, K. B., Teijaro, J. R., Wilker, P. R., Jatzek, A., Fremgen, D. M., Das, S. C., Watanabe, T., Hatta, M., Shinya, K., Suresh, M., Kawaoka, Y., Rosen, H., et al. Suppression of cytokine storm with a sphingosine analog provides protection against pathogenic influenza virus Proceedings of the National Academy of Sciences of the United States of America 2011 108:12018-12023 DOI:10.1073/pnas.1107024108 PMID:21715659 PMCID:PMC3142000
- Hemmers, S., Teijaro, J. R., Arandjelovic, S., Mowen, K. A. PAD4-mediated neutrophil extracellular trap formation is not required for immunity against influenza infection PLoS One 2011 6:e22043 DOI:10.1371/journal.pone.0022043 PMID:21779371 PMCID:PMC3133614
- Ayala, V. I., Teijaro, J. R., Farber, D. L., Dorsey, S. G., Carbonetti, N. H. Bordetella pertussis infection exacerbates influenza virus infection through pertussis toxin-mediated suppression of innate immunity PLoS One 2011 6:e19016 DOI:10.1371/journal.pone.0019016 PMID:21533103 PMCID:PMC3080395
- Popkin, D. L., Teijaro, J. R., Sullivan, B. M., Urata, S., Rutschmann, S., de la Torre, J. C., Kunz, S., Beutler, B., Oldstone, M. Hypomorphic mutation in the site-1 protease Mbtps1 endows resistance to persistent viral infection in a cell-specific manner Cell Host & Microbe 2011 9:212-222 DOI:10.1016/j.chom.2011.02.006 PMID:21402360 PMCID:PMC3058147
- Shirey, K. A., Nhu, Q. M., Yim, K. C., Roberts, Z. J., Teijaro, J. R., Farber, D. L., Blanco, J. C., Vogel, S. N. The anti-tumor agent, 5,6-dimethylxanthenone-4-acetic acid (DMXAA), induces IFN-beta-mediated antiviral activity in vitro and in vivo Journal of Leukocyte Biology 2011 89:351-357 DOI:10.1189/jlb.0410216 PMID:21084628 PMCID:PMC3040469
- Teijaro, J. R., Verhoeven, D., Page, C. A., Turner, D., Farber, D. L. Memory CD4 T cells direct protective responses to influenza virus in the lungs through helper-independent mechanisms Journal of Virology 2010 84:9217-9226 DOI:10.1128/jvi.01069-10 PMID:20592069 PMCID:PMC2937635
- Nhu, Q. M., Shirey, K., Teijaro, J. R., Farber, D. L., Netzel-Arnett, S., Antalis, T. M., Fasano, A., Vogel, S. N. Novel signaling interactions between proteinase-activated receptor 2 and Toll-like receptors in vitro and in vivo Mucosal Immunol 2010 3:29-39 DOI:10.1038/mi.2009.120 PMID:19865078 PMCID:PMC2851245
- Chandran, S. S., Verhoeven, D., Teijaro, J. R., Fenton, M. J., Farber, D. L. TLR2 engagement on dendritic cells promotes high frequency effector and memory CD4 T cell responses Journal of Immunology 2009 183:7832-7841 DOI:10.4049/jimmunol.0901683 PMID:19933854
- Verhoeven, D., Teijaro, J. R., Farber, D. L. Pulse-oximetry accurately predicts lung pathology and the immune response during influenza infection Virology 2009 390:151-156 DOI:10.1016/j.virol.2009.05.004 PMID:19493556 PMCID:PMC2776688
- Teijaro, J. R., Njau, M. N., Verhoeven, D., Chandran, S., Nadler, S. G., Hasday, J., Farber, D. L. Costimulation modulation uncouples protection from immunopathology in memory T cell responses to influenza virus Journal of Immunology 2009 182:6834-6843 DOI:10.4049/jimmunol.0803860 PMID:19454679
- Tang, A. L., Teijaro, J. R., Njau, M. N., Chandran, S. S., Azimzadeh, A., Nadler, S. G., Rothstein, D. M., Farber, D. L. CTLA4 expression is an indicator and regulator of steady-state CD4(+)FoxP3(+) T cell homeostasis Journal of Immunology 2008 181:1806-1813 DOI:10.4049/jimmunol.181.3.1806 PMID:18641318 PMCID:PMC2683757
- Casares, S., Lin, M., Zhang, N., Teijaro, J. R., Stoica, C., McEvoy, R., Farber, D. L., Bona, C., Brumeanu, T. D. A peptide-major histocompatibility complex II chimera favors survival of pancreatic beta-islets grafted in type 1 diabetic mice Transplantation 2008 85:1717-1725 DOI:10.1097/TP.0b013e31817752cc PMID:18580462
- Verhoeven, D., Teijaro, J. R., Farber, D. L. Heterogeneous memory T cells in antiviral immunity and immunopathology Viral Immunology 2008 21:99-113 DOI:10.1089/vim.2007.0002 PMID:18476772 PMCID:PMC2996251
- Ndejembi, M. P., Teijaro, J. R., Patke, D. S., Bingaman, A. W., Chandok, M. R., Azimzadeh, A., Nadler, S. G., Farber, D. L. Control of memory CD4 T cell recall by the CD28/B7 costimulatory pathway Journal of Immunology 2006 177:7698-7706 DOI:10.4049/jimmunol.177.11.7698 PMID:17114440