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Taffe, Michael
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Taffe, Michael

Faculty Member Adjunct
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Positions

  • 2019 - Professor Adjunct , Neuroscience , Scripps Research
  • 2017 - 2018 Associate Professor, Neuroscience , Scripps Research
  • 2007 - 2017 Associate Professor, Committee on the Neurobiology of Addictive Disorders (CNAD) , Scripps Research
  • 2005 - 2007 Assistant Professor, Molecular and Integrative Neurosciences (MIND) , Scripps Research
  • 2000 - 2005 Assistant Professor, Neuropharmacology , Scripps Research
  • 1996 - 2000 Postdoctoral Fellow, Neuropharmacology , Scripps Research
  • 1995 - 1996 Postdoctoral Fellow, University of California, San Diego
  • 1990 - 1995 Predoctoral Fellow, University of California, San Diego
Dr. Michael Taffe investigates the behavioral and physiological impact of exposure to stimulant (MDMA, methamphetamine, MDPV, methylone), prescription opioid (Oxycontin) and cannabinoid (THC, cannabidiol) drugs in rodent and nonhuman primate models.

Research Areas research areas

  • Alzheimer (UMLS)

Contact

  • mtaffe@scripps.edu

Websites

  • Michael Taffe, Ph.D.
  • Laboratory Website
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Publications

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    • Gutierrez, A., Nguyen, J. D., Creehan, K. M., Javadi-Paydar, M., Grant, Y., Taffe, M. A. Effects of combined THC and heroin vapor inhalation in rats Psychopharmacology  2021  DOI:10.1007/s00213-021-05904-w  PMID:34160641  PMCID:PMC8219787
    • Nguyen, Jacques D., Grant, Yanabel, Taffe, M. A. Paradoxical changes in brain reward status during oxycodone self-administration in a novel test of the negative reinforcement hypothesis British Journal of Pharmacology  2021 178:3797-3812  DOI:10.1111/bph.15520  PMID:33948939  PMCID:PMC8387405
    • Taffe, M. A., Nguyen, J. D., Vandewater, S. A., Grant, Y., Dickerson, T. J. Effects of α-pyrrolidino-phenone cathinone stimulants on locomotor behavior in female rats Drug and Alcohol Dependence  2021 227  DOI:10.1016/j.drugalcdep.2021.108910  PMID:34332176
    • Khom, S., Nguyen, J. D., Vandewater, S. A., Grant, Y., Roberto, M., Taffe, M. A. Self-Administration of Entactogen Psychostimulants Dysregulates Gamma-Aminobutyric Acid (GABA) and Kappa Opioid Receptor Signaling in the Central Nucleus of the Amygdala of Female Wistar Rats Frontiers in Behavioral Neuroscience  2021 15  DOI:10.3389/fnbeh.2021.780500  PMID:34975428  PMCID:PMC8716434
    • Gutierrez, Arnold, Nguyen, Jacques D., Creehan, Kevin M., Taffe, M. Female rats self-administer heroin by vapor inhalation Pharmacology Biochemistry and Behavior  2020 199  DOI:10.1016/j.pbb.2020.173061  PMID:33164848  PMCID:PMC7725943
    • Nguyen, J. D., Creehan, K. M., Grant, Y., Vandewater, S. A., Kerr, T. M., Taffe, M. A. Explication of CB 1 receptor contributions to the hypothermic effects of Δ 9-tetrahydrocannabinol (THC) when delivered by vapor inhalation or parenteral injection in rats Drug and Alcohol Dependence  2020 214  DOI:10.1016/j.drugalcdep.2020.108166  PMID:32717503  PMCID:PMC7423642
    • Taffe, M. A., Creehan, K. M., Vandewater, S. A., Kerr, T. M., Cole, M. Effects of Δ⁹-tetrahydrocannabinol (THC) vapor inhalation in Sprague-Dawley and Wistar rats Experimental and Clinical Psychopharmacology  2020 29:1-13  DOI:10.1037/pha0000373  PMID:32297788  PMCID:PMC8376092
    • Nguyen, J. D., Creehan, K. M., Kerr, T. M., Taffe, M. A. Lasting effects of repeated ∆9 -tetrahydrocannabinol vapour inhalation during adolescence in male and female rats British Journal of Pharmacology  2020  DOI:10.1111/bph.14856  PMID:31478558
    • Javadi-Paydar, M., Creehan, K. M., Kerr, T. M., Taffe, M. A. Vapor inhalation of cannabidiol (CBD) in rats Pharmacology Biochemistry and Behavior  2019 184  DOI:10.1016/j.pbb.2019.172741  PMID:31336109  PMCID:PMC6746317
    • Nguyen, J. D., Grant, Y., Creehan, K. M., Hwang, C. S., Vandewater, S. A., Janda, K. D., Cole, M., Taffe, M. A. Δ9-tetrahydrocannabinol attenuates oxycodone self-administration under extended access conditions Neuropharmacology  2019 151:127-135  DOI:10.1016/j.neuropharm.2019.04.010  PMID:30980837  PMCID:PMC6510273
    • Javadi-Paydar, M., Kerr, T. M., Harvey, E. L., Cole, M., Taffe, M. A. Effects of nicotine and THC vapor inhalation administered by an electronic nicotine delivery system (ENDS) in male rats Drug and Alcohol Dependence  2019 198:54-62  DOI:10.1016/j.drugalcdep.2019.01.027  PMID:30878767  PMCID:PMC6467722
    • Javadi-Paydar, M., Nguyen, J. D., Kerr, T. M., Grant, Y., Vandewater, S. A., Cole, M., Taffe, M. A. Effects of Δ9-THC and cannabidiol vapor inhalation in male and female rats Psychopharmacology  2018 235:2541-2557  DOI:10.1007/s00213-018-4946-0  PMID:29907926
    • Nguyen, J. D., Grant, Y., Kerr, T. M., Gutierrez, A., Cole, M., Taffe, M. A. Tolerance to hypothermic and antinoceptive effects of ∆9-tetrahydrocannabinol (THC) vapor inhalation in rats Pharmacology Biochemistry and Behavior  2018 172:33-38  DOI:10.1016/j.pbb.2018.07.007  PMID:30031028
    • Javadi-Paydar, M., Harvey, E. L., Grant, Y., Vandewater, S. A., Creehan, K. M., Nguyen, J. D., Dickerson, T. J., Taffe, M. A. Binge-like acquisition of α-pyrrolidinopentiophenone (α-PVP) self-administration in female rats Psychopharmacology  2018 235:2447-2457  DOI:10.1007/s00213-018-4943-3  PMID:29909425
    • Nguyen, J. D., Hwang, C. S., Grant, Y., Janda, K. D., Taffe, M. A. Prophylactic vaccination protects against the development of oxycodone self-administration Neuropharmacology  2018 138:292-303  DOI:10.1016/j.neuropharm.2018.06.026  PMID:29936242
    • Dutta, R. R., Taffe, M. A., Mandyam, C. D. Chronic administration of amphetamines disturbs development of neural progenitor cells in young adult nonhuman primates Progress in Neuro-Psychopharmacology & Biological Psychiatry  2018 85:46-53  DOI:10.1016/j.pnpbp.2018.03.023  PMID:29601895  PMCID:PMC5962428
    • Taffe, M. A., Olive, M. F. Designer drugs - A continuing chemical (R)evolution Neuropharmacology  2018 134:1-3  DOI:10.1016/j.neuropharm.2018.03.037  PMID:29605651
    • Javadi-Paydar, M., Nguyen, J. D., Vandewater, S. A., Dickerson, T. J., Taffe, M. A. Locomotor and reinforcing effects of pentedrone, pentylone and methylone in rats Neuropharmacology  2018 134:57-64  DOI:10.1016/j.neuropharm.2017.09.002  PMID:28882561  PMCID:PMC5835165
    • Vendruscolo, J. C. M., Tunstall, B. J., Carmack, S. A., Schmeichel, B. E., Lowery-Gionta, E. G., Cole, M., George, O., Vandewater, S. A., Taffe, M. A., Koob, G. F., Vendruscolo, L. F. Compulsive-like sufentanil vapor self-administration in rats Neuropsychopharmacology  2018 43:801-809  DOI:10.1038/npp.2017.172  PMID:28812595  PMCID:PMC5809787
    • Boggs, D. L., Nguyen, J. D., Morgenson, D., Taffe, M. A., Ranganathan, M. Clinical and preclinical evidence for functional interactions of cannabidiol and Δ9-tetrahydrocannabinol Neuropsychopharmacology  2018 43:142-154  DOI:10.1038/npp.2017.209  PMID:28875990  PMCID:PMC5719112
    • Aarde, S. M., Huang, P. K., Taffe, M. A. High ambient temperature facilitates the acquisition of 3,4-methylenedioxymethamphetamine (MDMA) self-administration Pharmacology Biochemistry and Behavior  2017 163:38-49  DOI:10.1016/j.pbb.2017.10.008  PMID:29054819
    • Nguyen, J. D., Grant, Y., Creehan, K. M., Vandewater, S. A., Taffe, M. A. Escalation of intravenous self-administration of methylone and mephedrone under extended access conditions Addiction Biology  2017 22:1160-1168  DOI:10.1111/adb.12398  PMID:27046454  PMCID:PMC5052089
    • Nguyen, J. D., Bremer, P. T., Hwang, C. S., Vandewater, S. A., Collins, K. C., Creehan, K. M., Janda, K. D., Taffe, M. A. Effective active vaccination against methamphetamine in female rats Drug and Alcohol Dependence  2017 175:179-186  DOI:10.1016/j.drugalcdep.2017.03.005  PMID:28437722
    • Nguyen, J. D., Bremer, P. T., Ducime, A., Creehan, K. M., Kisby, B. R., Taffe, M. A., Janda, K. D. Active vaccination attenuates the psychostimulant effects of α-PVP and MDPV in rats Neuropharmacology  2016 116:1-8  DOI:10.1016/j.neuropharm.2016.12.005  PMID:27956054  PMCID:PMC5385148
    • Nguyen, J. D., Aarde, S. M., Vandewater, S. A., Grant, Y., Stouffer, D. G., Parsons, L. H., Cole, M., Taffe, M. A. Inhaled delivery of Δ(9)-tetrahydrocannabinol (THC) to rats by e-cigarette vapor technology Neuropharmacology  2016 109:112-120  DOI:10.1016/j.neuropharm.2016.05.021  PMID:27256501  PMCID:PMC4970926
    • Nguyen, J. D., Aarde, S. M., Cole, M., Vandewater, S. A., Grant, Y., Taffe, M. A. Locomotor Stimulant and Rewarding Effects of Inhaling Methamphetamine, MDPV, and Mephedrone via Electronic Cigarette-Type Technology Neuropsychopharmacology  2016 41:2759-2771  DOI:10.1038/npp.2016.88  PMID:27277119  PMCID:PMC5026745
    • Taffe, M. A., Nguyen, J. D., Bremer, P. T., Vandewater, S. A., Creehan, K. M., Janda, K. D. Active anti-methamphetamine vaccination attenuates the effects of methamphetamine The FASEB Journal  2016 30
    • Vandewater, S. A., Creehan, K. M., Taffe, M. A. Intravenous self-administration of entactogen-class stimulants in male rats Neuropharmacology  2015 99:538-545  DOI:10.1016/j.neuropharm.2015.08.030  PMID:26302654  PMCID:PMC4655153
    • Miller, M. L., Aarde, S. M., Moreno, A. Y., Creehan, K. M., Janda, K. D., Taffe, M. A. Effects of active anti-methamphetamine vaccination on intravenous self-administration in rats Drug and Alcohol Dependence  2015 153:29-36  DOI:10.1016/j.drugalcdep.2015.06.014  PMID:26118833  PMCID:PMC4509945
    • Aarde, S. M., Creehan, K. M., Vandewater, S. A., Dickerson, T. J., Taffe, M. A. In vivo potency and efficacy of the novel cathinone α-pyrrolidinopentiophenone and 3,4-methylenedioxypyrovalerone: self-administration and locomotor stimulation in male rats Psychopharmacology  2015 232:3045-3055  DOI:10.1007/s00213-015-3944-8  PMID:25925780  PMCID:PMC4515201
    • Aarde, S. M., Huang, P. K., Dickerson, T. J., Taffe, M. Binge-like acquisition of 3,4-methylenedioxypyrovalerone (MDPV) self-administration and wheel activity in rats Psychopharmacology  2015 232:1867-1877  DOI:10.1007/s00213-014-3819-4  PMID:25424056  PMCID:PMC4426253
    • Aarde, S. M., Miller, M. L., Creehan, K. M., Vandewater, S. A., Taffe, M. A. One day access to a running wheel reduces self-administration of d-methamphetamine, MDMA and methylone Drug and Alcohol Dependence  2015 151:151-158  DOI:10.1016/j.drugalcdep.2015.03.016  PMID:25863714  PMCID:PMC4447594
    • Creehan, K. M., Vandewater, S. A., Taffe, M. A. Intravenous self-administration of mephedrone, methylone and MDMA in female rats Neuropharmacology  2015 92:90-97  DOI:10.1016/j.neuropharm.2015.01.003  PMID:25600245  PMCID:PMC4346510
    • Taffe, M. A., Creehan, K. M., Vandewater, S. A. Cannabidiol fails to reverse hypothermia or locomotor suppression induced by Δ(9)-tetrahydrocannabinol in Sprague-Dawley rats British Journal of Pharmacology  2015 172:1783-1791  DOI:10.1111/bph.13024  PMID:25425111  PMCID:PMC4376456
    • Wright Jr., M. J., Taffe, M. A. Chronic periadolescent alcohol consumption produces persistent cognitive deficits in rhesus macaques Neuropharmacology  2014 86:78-87  DOI:10.1016/j.neuropharm.2014.07.003  PMID:25018042  PMCID:PMC4188799
    • Aarde, S. M., Huang, P. K., Creehan, K. M., Dickerson, T. J., Taffe, M. A. The novel recreational drug 3,4-methylenedioxypyrovalerone (MDPV) is a potent psychomotor stimulant: Self-administration and locomotor activity in rats Neuropharmacology  2013 71:130-140  DOI:10.1016/j.neuropharm.2013.04.003  PMID:23597511  PMCID:PMC3681807
    • Wright, M. J., Vandewater, S. A., Taffe, M. A. The influence of acute and chronic alcohol consumption on response time distribution in adolescent rhesus macaques Neuropharmacology  2013 70:12-18  DOI:10.1016/j.neuropharm.2013.01.003  PMID:23321688  PMCID:PMC3636163
    • Wright, M. J., Glavis-Bloom, C., Taffe, M. A. Acute ethanol reduces reversal cost in discrimination learning by reducing perseverance in adolescent rhesus macaques Alcoholism-Clinical and Experimental Research  2013 37:952-960  DOI:10.1111/acer.12050  PMID:23298170  PMCID:PMC4455938
    • Miller, M. L., Moreno, A. Y., Aarde, S. M., Creehan, K. M., Vandewater, S. A., Vaillancourt, B. D., Wright, M. J., Jr., Janda, K. D., Taffe, M. A. A methamphetamine vaccine attenuates methamphetamine-induced disruptions in thermoregulation and activity in rats Biological Psychiatry  2013 73:721-8  DOI:10.1016/j.biopsych.2012.09.010  PMID:23098894  PMCID:PMC3561477
    • Wright, M. J., Vandewater, S. A., Parsons, L. H., Taffe, M. A. delta(9)Tetrahydrocannabinol impairs reversal learning but not extra-dimensional shifts in rhesus macaques Neuroscience  2013 235:51-58  DOI:10.1016/j.neuroscience.2013.01.018  PMID:23333671  PMCID:PMC3595391
    • Wright Jr, M. J., Vandewater, S. A., Taffe, M. A. Cannabidiol attenuates deficits of visuo-spatial associative memory induced by Δ9 tetrahydrocannabinol British Journal of Pharmacology  2013  DOI:10.1111/bph.12199  PMID:23550724  PMCID:PMC3838683
    • Miller, M. L., Creehan, K. M., Angrish, D., Barlow, D. J., Houseknecht, K. L., Dickerson, T. J., Taffe, M. A. Changes in ambient temperature differentially alter the thermoregulatory, cardiac and locomotor stimulant effects of 4-methylmethcathinone (mephedrone) Drug and Alcohol Dependence  2013 127:248-253  DOI:10.1016/j.drugalcdep.2012.07.003  PMID:22832282  PMCID:PMC3491086
    • Aarde, S. M., Angrish, D., Barlow, D. J., Wright, M. J., Vandewater, S. A., Creehan, K. M., Houseknecht, K. L., Dickerson, T. J., Taffe, M. A. Mephedrone (4-methylmethcathinone) supports intravenous self-administration in Sprague-Dawley and Wistar rats Addiction Biology  2013 18:786-799  DOI:10.1111/adb.12038  PMID:23363010  PMCID:PMC3641159
    • Aarde, S. M., Angrish, D., Barlow, D. J., Wright Jr, M. J., Vandewater, S. A., Creehan, K. M., Houseknecht, K. L., Dickerson, T. J., Taffe, M. A. Mephedrone (4-methylmethcathinone) supports intravenous self-administration in sprague-dawley and wistar rats Addiction Biology  2013  DOI:10.1111/adb.12038  PMID:23363010  PMCID:PMC3641159
    • Huang, P. K., Aarde, S. M., Angrish, D., Houseknecht, K. L., Dickerson, T. J., Taffe, M. A. Contrasting effects of d-methamphetamine, 3,4-methylenedioxymethamphetamine, 3,4-methylenedioxypyrovalerone, and 4-methylmethcathinone on wheel activity in rats Drug and Alcohol Dependence  2012 126:168-175  DOI:10.1016/j.drugalcdep.2012.05.011  PMID:22664136  PMCID:PMC3439532
    • Taffe, M. A. Delta(9)tetrahydrocannabinol impairs visuo-spatial associative learning and spatial working memory in rhesus macaques Journal of Psychopharmacology  2012 26:1299-1306  DOI:10.1177/0269881112443743  PMID:22526684  PMCID:PMC3560534
    • Wright, M. J., Angrish, D., Aarde, S. M., Barlow, D. J., Buczynski, M. W., Creehan, K. M., Vandewater, S. A., Parsons, L. H., Houseknecht, K. L., Dickerson, T. J., Taffe, M. A. Effect of ambient temperature on the thermoregulatory and locomotor stimulant effects of 4-methylmethcathinone in Wistar and Sprague-Dawley rats PLoS One  2012 7:e44652  DOI:10.1371/journal.pone.0044652  PMID:22952999  PMCID:PMC3432134
    • Miller, M. L., Vaillancourt, B. D., Wright, M. J., Aarde, S. M., Vandewater, S. A., Creehan, K. M., Taffe, M. A. Reciprocal inhibitory effects of intravenous d-methamphetamine self-administration and wheel activity in rats Drug and Alcohol Dependence  2012 121:90-96  DOI:10.1016/j.drugalcdep.2011.08.013  PMID:21899959  PMCID:PMC3235246
    • Taffe, M. A. Delta(9)-tetrahydrocannabinol attenuates mdma-induced hyperthermia in rhesus monkeys Neuroscience  2012 201:125-133  DOI:10.1016/j.neuroscience.2011.11.040  PMID:22138434  PMCID:PMC3258357
    • Wright, M. J., Vandewater, S. A., Angrish, D., Dickerson, T. J., Taffe, M. A. Mephedrone (4-methylmethcathinone) and d-methamphetamine improve visuospatial associative memory, but not spatial working memory, in rhesus macaques British Journal of Pharmacology  2012 167:1342-1352  DOI:10.1111/j.1476-5381.2012.02091.x  PMID:22748013  PMCID:PMC3504998
    • Taffe, M. A., Taffe, W. J. Rhesus monkeys employ a procedural strategy to reduce working memory load in a self-ordered spatial search task Brain Research  2011 1413:43-50  DOI:10.1016/j.brainres.2011.07.048  PMID:21840507  PMCID:PMC3167000
    • Gilpin, N. W., Wright, M. J., Dickinson, G., Vandewater, S. A., Price, J. U., Taffe, M. A. Influences of activity wheel access on the body temperature response to mdma and methamphetamine Pharmacology, Biochemistry and Behavior  2011 99:295-300  DOI:10.1016/j.pbb.2011.05.006  PMID:21605589  PMCID:PMC3129476
    • Taffe, M. A. A comparison of intraperitoneal and subcutaneous temperature in freely moving rhesus macaques Physiology & Behavior  2011 103:440-444  DOI:10.1016/j.physbeh.2011.03.023  PMID:21443893  PMCID:PMC3107936
    • Crean, R. D., Vandewater, S. A., Katner, S. N., Huitron-Resendiz, S., Taffe, M. A. Chronic alcohol consumption impairs visuo-spatial associative memory in periadolescent rhesus monkeys Drug and Alcohol Dependence  2011 114:31-40  DOI:10.1016/j.drugalcdep.2010.09.002  PMID:20951512  PMCID:PMC3024459
    • Taffe, M. A., Kotzebue, R. W., Crean, R. D., Crawford, E. F., Edwards, S., Mandyam, C. D. Long-lasting reduction in hippocampal neurogenesis by alcohol consumption in adolescent nonhuman primates Proceedings of the National Academy of Sciences of the United States of America  2010 107:11104-11109  DOI:10.1073/pnas.0912810107  PMID:20534463  PMCID:PMC2890755
    • Marcondes, M. C. G., Watry, D., Zandonatti, M., Flynn, C., Taffe, M. A., Fox, H. Chronic alcohol consumption generates a vulnerable immune environment during early SIV infection in rhesus macaques Alcoholism-Clinical and Experimental Research  2008 32:1583-1592  DOI:10.1111/j.1530-0277.2008.00730.x  PMID:18616669  PMCID:PMC2579901
    • Katner, S. N., Von Huben, S. N., Davis, S. A., Lay, C. C., Crean, R. D., Roberts, A. J., Fox, H. S., Taffe, M. A. Robust and stable drinking behavior following long-term oral alcohol intake in rhesus macaques Drug and Alcohol Dependence  2007 91:236-243  DOI:10.1016/j.drugalcdep.2007.06.002  PMID:17628350  PMCID:PMC2231844
    • Crean, R. D., Davis, S. A., Taffe, M. A. Oral administration of (+/-)3,4-methylenedioxymethamphetamine and (+)methamphetamine alters temperature and activity in rhesus macaques Pharmacology, Biochemistry and Behavior  2007 87:11-19  DOI:10.1016/j.pbb.2007.03.015  PMID:17475314  PMCID:PMC1975960
    • Von Huben, S. N., Lay, C. C., D Crean, R., Davis, S. A., Katner, S. N., Taffe, M. A. Impact of ambient temperature on hyperthermia induced by (+/-)3,4-methylenedioxymethamphetamine in rhesus macaques Neuropsychopharmacology  2007 32:673-681  DOI:10.1038/sj.npp.1301078  PMID:16641942  PMCID:PMC2080863
    • Von Huben, S. N., Davis, S. A., Lay, C. C., Katner, S. N., Crean, R. D., Taffe, M. A. Differential contributions of dopaminergic d-1- and d-2-like receptors to cognitive function in rhesus monkeys Psychopharmacology  2006 188:586-596  DOI:10.1007/s00213-006-0347-x  PMID:16538469  PMCID:PMC2099258
    • Crean, R. D., Davis, S. A., Von Huben, S. N., Lay, C. C., Katner, S. N., Taffe, M. A. Effects of (+/-)3,4-methylenedioxymethamphetamine, (+/-)3,4-methylenedioxyamphetamine and methamphetamine on temperature and activity in rhesus macaques Neuroscience  2006 142:515-525  DOI:10.1016/j.neuroscience.2006.06.033  PMID:16876329  PMCID:PMC1853374
    • Taffe, M. A., Lay, C. C., Von Huben, S. N., Davis, S. A., Crean, R. D., Katner, S. N. Hyperthermia induced by 3,4-methylenedioxymethamphetamine in unrestrained rhesus monkeys Drug and Alcohol Dependence  2006 82:276-281  DOI:10.1016/j.drugalcdep.2005.09.013  PMID:16289931  PMCID:PMC1551973
    • Roberts, E. S., Huitron-Rosendiz, S., Taffe, M. A., Marcondes, M. C. G., Flynn, C. T., Lanigan, C. M., Hammond, J. A., Head, S. R., Henriksen, S. J., Fox, H. S. Host response and dysfunction in the CNS during chronic simian immunodeficiency virus infection Journal of Neuroscience  2006 26:4577-4585  DOI:10.1523/jneurosci.4504-05.2006  PMID:16641237
    • Burdo, T. H., Katner, S. N., Taffe, M. A., Fox, H. S. Neuroimmunity, drugs of abuse, and neuroaids Journal of Neuroimmune Pharmacology  2006 1:41-49  DOI:10.1007/s11481-005-9001-3  PMID:18040790
    • Roberts, E. S., Burudi, E. M. E., Flynn, C., Madden, L. J., Roinick, K. L., Watry, D. D., Zandonatti, M. A., Taffe, M. A., Fox, H. S. Acute SIV infection of the brain leads to upregulation of IL6 ad interferon-regulated genes: expression patterns throughout disease progression and impact on neuroAIDS Journal of Neuroimmunology  2004 157:81-92  DOI:10.1016/j.jneuroim.2004.08.030  PMID:15579284
    • Katner, S. N., Davis, S. A., Kirsten, A. J., Taffe, M. A. Effects of nicotine and mecamylamine on cognition in rhesus monkeys Psychopharmacology  2004 175:225-240  DOI:10.1007/s00213-004-1804-z  PMID:15112030  PMCID:PMC2121304
    • Katner, S. N., Flynn, C. T., Von Huben, S. N., Kirsten, A. J., Davis, S. A., Lay, C. C., Cole, M., Roberts, A. J., Fox, H. S., Taffe, M. A. Controlled and behaviorally relevant levels of oral ethanol intake in rhesus macaques using a flavorant-fade procedure Alcoholism-Clinical and Experimental Research  2004 28:873-883  DOI:10.1097/01.alc.0000128895.99379.8c  PMID:15201630
    • Taffe, M. A., Weed, M. R., Gutierrez, T., Davis, S. A., Gold, L. H. Modeling a task that is sensitive to dementia of the Alzheimer's type: individual differences in acquisition of a visuo-spatial paired-associate learning task in rhesus monkeys Behavioural Brain Research  2004 149:123-133  DOI:10.1016/s0166-4328(03)00214-6  PMID:15129776
    • Madden, L. J., Zandonatti, M. A., Flynn, C. T., Taffe, M. A., Marcondes, M. C. G., Schmitz, J. E., Reimann, K. A., Henriksen, S. J., Fox, H. S. CD8+ cell depletion amplifies the acute retroviral syndrome Journal of Neurovirology  2004 10:58-66  DOI:10.1080/13550280490268269  PMID:14982741
    • Taffe, M. A. Effects of parametric feeding manipulations on behavioral performance in macaques Physiology & Behavior  2004 81:59-70  DOI:10.1016/j.physbeh.2003.12.011  PMID:15059685
    • Weed, M. R., Gold, L. H., Polis, I., Koob, G. F., Fox, H. S., Taffe, M. A. Impaired performance on a rhesus monkey neuropsychological testing battery following simian immunodeficiency virus infection AIDS Research and Human Retroviruses  2004 20:77-89  DOI:10.1089/088922204322749521  PMID:15000701
    • Taffe, M. A., Huitron-Resendiz, S., Schroeder, R., Parsons, L. H., Henriksen, S. J., Gold, L. H. MDMA exposure alters cognitive and electrophysiological sensitivity to rapid tryptophan depletion in rhesus monkeys Pharmacology, Biochemistry and Behavior  2003 76:141-152  DOI:10.1016/s0091-3057(03)00217-x  PMID:13679227
    • Roberts, E. S., Zandonatti, M. A., Watry, D. D., Madden, L. J., Henriksen, S. J., Taffe, M. A., Fox, H. S. Induction of pathogenic sets of genes in macrophages and neurons in neuroAIDS American Journal of Pathology  2003 162:2041-2057  DOI:10.1016/s0002-9440(10)64336-2  PMID:12759259  PMCID:PMC1868118
    • Taffe, M. A., Davis, S. A., Yuan, J., Schroeder, R., Hatzidimitriou, G., Parsons, L. H., Ricaurte, G. A., Gold, L. H. Cognitive performance of MDMA-treated rhesus monkeys: sensitivity to serotonergic challenge Neuropsychopharmacology  2002 27:993-1005  DOI:10.1016/s0893-133x(02)00380-9  PMID:12464456
    • Burudi, E. M. E., Marcondes, M. C. G., Watry, D. D., Zandonatti, M., Taffe, M. A., Fox, H. S. Regulation of indoleamine 2,3-dioxygenase expression in simian immunodeficiency virus-infected monkey brains Journal of Virology  2002 76:12233-12241  DOI:10.1128/jvi.76.23.12233-12241.2002  PMID:12414962  PMCID:PMC136861
    • Taffe, M. A., Davis, S. A., Gutierrez, T., Gold, L. H. Ketamine impairs multiple cognitive domains in rhesus monkeys Drug and Alcohol Dependence  2002 68:175-187  DOI:10.1016/s0376-8716(02)00194-1  PMID:12234647
    • Taffe, M. A., Weed, M. R., Gutierrez, T., Davis, S. A., Gold, L. H. Differential muscarinic and NMDA contributions to visuo-spatial paired-associate learning in rhesus monkeys Psychopharmacology  2002 160:253-262  DOI:10.1007/s00213-001-0954-5  PMID:11889494  PMCID:PMC4077277
    • Taffe, M. A., Weed, M. R., Davis, S., Huitron-Resendiz, S., Schroeder, R., Parsons, L. H., Henriksen, S. J., Gold, L. H. Functional consequences of repeated (+/-)3,4-methylenedioxymethamphetamine (MDMA) treatment in rhesus monkeys Neuropsychopharmacology  2001 24:230-239  DOI:10.1016/s0893-133x(00)00185-8  PMID:11166514
    • Weed, M. R., Taffe, M. A., Polis, I., Roberts, A. C., Robbins, T. W., Koob, G. F., Bloom, F. E., Gold, L. H. Performance norms for a rhesus monkey neuropsychological testing battery: acquisition and long-term performance Cognitive Brain Research  1999 8:185-201  DOI:10.1016/s0926-6410(99)00020-8  PMID:10556598
    • Taffe, M. A., Weed, M. R., Gold, L. H. Scopolamine alters rhesus monkey performance on a novel neuropsychological test battery Cognitive Brain Research  1999 8:203-212  DOI:10.1016/s0926-6410(99)00021-x  PMID:10556599
    • Gold, L. H., Fox, H. S., Henriksen, S. J., Buchmeier, M. J., Weed, M. R., Taffe, M. A., Huitron-Resendiz, S., Horn, T. F. W., Bloom, F. E. Longitudinal analysis of behavioral, neurophysiological, viral and immunological effects of SIV infection in rhesus monkeys Journal of Medical Primatology  1998 27:104-112  DOI:10.1111/j.1600-0684.1998.tb00234.x  PMID:9747951

featured in

  • Scripps Research Team Wins $4 Million Grant to Study Effects of Chronic Marijuana Use  News Release
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Research

research overview

  • Substance Abuse Therapy

    Methamphetamine: Addiction to d-methamphetamine (METH) interferes with many aspects of personal health, vocational performance, interpersonal relationships and financial well being. Behavioral consequences of METH abuse and the METH trade also strain legal and emergency medical resources throughout the US. Current therapeutic approaches for METH addiction are less than completely effective and no approved pharmacotherapies for METH addiction exist. Recent successes in early clinical trials using immunotherapeutic approaches for cocaine and nicotine addiction have motivated interest in creating similar approaches for methamphetamine addiction. The studies currently underway will create candidate active vaccines specific for METH (MCV) and evaluate the most promising candidates in a cascade of in vivo models.

    Neuropharmacology of Drug Addiction

    Substituted Cathinone "Bath Salts": A diverse array of new stimulant drugs based on the cathinone core structure emerged on worldwide markets starting around 2008-2009. Early entities included drugs such as 4-methylmethcathinone (4-MMC, mephedrone), 3,4-methylenedioxypyrovalerone (MDPV) and 3,4-methylenedioxymethcathinone (methylone). Some exhibit neuropharmacological actions similar to MDMA, some are more similar to cocaine and some are more similar to traditional amphetamine stimulants such as methamphetamine. There are now over a dozen cathinone entities which have been placed under Schedule I control by the US DEA, and more of them may follow in an attempt to evade legal control. Our goal with the cathinone project is to determine how the pharmacological differences between these entities confer different risks for compulsive use and for thermoregulatory disruption of a life-threatening nature.

    Cognitive Effects of Exposure to Abused Drugs

    Individuals who ingest recreational drugs have been shown to exhibit a number of cognitive or behavioral impairments. Conclusive linking of such behavioral problems to a specific drug or pattern of chronic use is complicated by the fact that most drug users have substantial rates of exposure to multiple drugs concurrently and across time. In particular, exposure to alcohol, delta-9-tetrahydrocannabinol (THC) and nicotine is common in users of most other drugs. Furthermore, it is impossible to demonstrate that cognitive performance levels in recreational users are not merely a reflection of pre-existing group differences. Thus animal models are necessary to demonstrate a causal relationship between a specific pattern of drug exposure and the observed behavioral or cognitive impairment.

principal investigator on

  • R01 DA024705
  • R01 DA035281
  • R01 DA035482
  • R01 DA042211

investigator on

  • R44 DA042595
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Background

education and training

  • Ph.D. in Psychology, University of California, San Diego 1990 - 1995
  • M.A. in Psychology, University of California, San Diego 1992
  • B.A. in Psychology, Colorado College 1990
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Contact

full name

  • Michael A. Taffe

geographic location

  • Scripps California 
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Identity

ORCID iD

  • ORCID iD http://orcid.org/0000-0001-9827-1738

Scopus ID

  • 6603378605

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