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Tabarean, Iustin
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Tabarean, Iustin

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Positions

  • 2015 - 2016 Assistant Professor of Neuroscience, Molecular and Cellular Neuroscience (MCN) , Scripps Research
  • 2013 - 2015 Assistant Professor, Molecular and Cellular Neuroscience (MCN) , Scripps Research
  • 2007 - 2012 Assistant Professor, Molecular and Integrative Neurosciences (MIND) , Scripps Research
  • 2002 - 2006 Research Associate, Molecular and Integrative Neurosciences (MIND) , Scripps Research
  • 1998 - 2002 Postdoctoral Research Fellow, Ottawa Hospital Research Institute , The Ottawa Hospital

Research Areas research areas

  • Diabetes (UMLS)
  • Obesity (UMLS)
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Publications

recent publications

  • academic article

    • Tabarean, I. V. Histamine receptor signaling in energy homeostasis Neuropharmacology  2016 106:13-19  DOI:10.1016/j.neuropharm.2015.04.011  PMID:26107117  PMCID:PMC4686377
    • Tabarean, I. V. Histamine receptor signaling in energy homeostasis Neuropharmacology  2016 106:13-19  DOI:10.1016/j.neuropharm.2015.04.011  PMID:26107117  PMCID:PMC4686377
    • Tabarean, I. V. Electrical remodeling of preoptic GABAergic neurons involves the Kv1.5 subunit PLoS One  2014 9:e96643  DOI:10.1371/journal.pone.0096643  PMID:24797243  PMCID:PMC4010509
    • Tabarean, I. V. Functional pharmacology of H-1 histamine receptors expressed in mouse preoptic/anterior hypothalamic neurons British Journal of Pharmacology  2013 170:415-425  DOI:10.1111/bph.12286  PMID:23808378  PMCID:PMC3834764
    • Tabarean, I. V. Persistent histamine excitation of glutamatergic preoptic neurons PLoS One  2012 7:e47700  DOI:10.1371/journal.pone.0047700  PMID:23082195  PMCID:PMC3474751
    • Sethi, J., Sanchez-Alavez, M., Tabarean, I. V. Loss of histaminergic modulation of thermoregulation and energy homeostasis in obese mice Neuroscience  2012 217:84-95  DOI:10.1016/j.neuroscience.2012.04.068  PMID:22579982  PMCID:PMC3383442
    • Tabarean, I. V., Sanchez-Alavez, M., Sethi, J. Mechanism of H₂ histamine receptor dependent modulation of body temperature and neuronall activity in the medial preoptic nucleus Neuropharmacology  2012 63:171-180  DOI:10.1016/j.neuropharm.2012.02.006  PMID:22366077  PMCID:PMC3372691
    • Sethi, J., Sanchez-Alavez, M., Tabarean, I. V. Kv4.2 mediates histamine modulation of preoptic neuron activity and body temperature PLoS One  2011 6:e29134  DOI:10.1371/journal.pone.0029134  PMID:22220205  PMCID:PMC3248414
    • Klein, I., Sanchez-Alavez, M., Tabarean, I., Schaefer, J., Holmberg, K. H., Klaus, J., Xia, F. C., Marcondes, M. C. G., Dubins, J. S., Morrison, B., Zhukov, V., Sanchez-Gonzalez, A., et al. AdipoR1 and 2 are expressed on warm sensitive neurons of the hypothalamic preoptic area and contribute to central hyperthermic effects of adiponectin Brain Research  2011 1423:1-9  DOI:10.1016/j.brainres.2011.09.019  PMID:22000082  PMCID:PMC3215583
    • Sanchez-Alavez, M., Osborn, O., Tabarean, I. V., Holmberg, K. H., Eberwine, J., Kahn, C. R., Bartfai, T. Insulin-like growth factor 1-mediated hyperthermia involves anterior hypothalamic insulin receptors Journal of Biological Chemistry  2011 286:14983-14990  DOI:10.1074/jbc.M110.188540  PMID:21330367  PMCID:PMC3083203
    • Scott, D. A., Tabarean, I., Tang, Y., Cartier, A., Masliah, E., Roy, S. A pathologic cascade leading to synaptic dysfunction in alpha-synuclein-induced neurodegeneration Journal of Neuroscience  2010 30:8083-8095  DOI:10.1523/jneurosci.1091-10.2010  PMID:20554859  PMCID:PMC2901533
    • Lundius, E. G., Sanchez-Alavez, M., Ghochani, Y., Klaus, J., Tabarean, I. V. Histamine influences body temperature by acting at h1 and h3 receptors on distinct populations of preoptic neurons Journal of Neuroscience  2010 30:4369-4381  DOI:10.1523/jneurosci.0378-10.2010  PMID:20335473  PMCID:PMC2853029
    • Tabarean, I., Morrison, B., Marcondes, M. C., Bartfai, T., Conti, B. Hypothalamic and dietary control of temperature-mediated longevity Ageing Research Reviews  2010 9:41-50  DOI:10.1016/j.arr.2009.07.004  PMID:19631766  PMCID:PMC2818054
    • Sanchez-Alavez, M., Tabarean, I. V., Osborn, O., Mitsukawa, K., Schaefer, J., Dubins, J., Holmberg, K. H., Klein, I., Klaus, J., Gomez, L. F., Kolb, H., Secrest, J., et al. Insulin causes hyperthermia by direct inhibition of warm-sensitive neurons Diabetes  2010 59:43-50  DOI:10.2337/db09-1128  PMID:19846801  PMCID:PMC2797943
    • Conti, B., Tabarean, I., Sanchez-Alavez, M., Davis, C., Brownell, S., Behrens, M., Bartfai, T. Cytokine receptors in the brain Neuroimmune Biology  2008 6:19-28  DOI:10.1016/S1567-7443(07)10002-8
    • Sanchez-Alavez, M., Klein, I., Brownell, S. E., Tabarean, I. V., Davis, C. N., Conti, B., Bartfai, T. Night eating and obesity in the EP3R-deficient mouse Proceedings of the National Academy of Sciences of the United States of America  2007 104:3009-3014  DOI:10.1073/pnas.0611209104  PMID:17307874  PMCID:PMC1800735
    • Calabrese, B., Shaked, G. M., Tabarean, I. V., Braga, J., Koo, E. H., Halpain, S. Rapid, concurrent alterations in pre- and postsynaptic structure induced by naturally-secreted amyloid-beta protein Molecular and Cellular Neuroscience  2007 35:183-193  DOI:10.1016/j.mcn.2007.02.006  PMID:17368908  PMCID:PMC2268524
    • Davis, C. N., Tabarean, I., Gaidarova, S., Behrens, M. M., Bartfai, T. IL-1β induces a MyD88-dependent and ceramide-mediated activation of Src in anterior hypothalamic neurons Journal of Neurochemistry  2006 98:1379-1389  DOI:10.1111/j.1471-4159.2006.03951.x  PMID:16771830
    • Sanchez-Alavez, M., Tabarean, I. V., Behrens, M. M., Bartfai, T. Ceramide mediates the rapid phase of febrile response to IL-1β Proceedings of the National Academy of Sciences of the United States of America  2006 103:2904-2908  DOI:10.1073/pnas.0510960103  PMID:16477014  PMCID:PMC1413811
    • Kinney, J. W., Davis, C. N., Tabarean, I., Conti, B., Bartfai, T., Behrens, M. M. A specific role for NR2A-containing NMDA receptors in the maintenance of parvalbumin and GAD67 immunoreactivity in cultured interneurons Journal of Neuroscience  2006 26:1604-1615  DOI:10.1523/jneurosci.4722-05.2006  PMID:16452684
    • Tabarean, I. V., Korn, H., Bartfai, T. Interleukin-1 beta induces hyperpolarization and modulates synaptic inhibition in preoptic and anterior hypothalamic neurons Neuroscience  2006 141:1685-1695  DOI:10.1016/j.neuroscience.2006.05.007  PMID:16777343
    • Tabarean, I. V., Conti, B., Behrens, M., Korn, H., Bartfai, T. Electrophysiological properties and thermosensitivity of mouse preoptic and anterior hypothalamic neurons in culture Neuroscience  2005 135:433-449  DOI:10.1016/j.neuroscience.2005.06.053  PMID:16112471
    • Conti, B., Tabarean, I., Andrei, C., Bartfai, T. Cytokines and fever Frontiers in Bioscience  2004 9:1433-1449  DOI:10.2741/1341  PMID:14977558
    • Tabarean, I. V., Behrens, M. M., Bartfai, T., Korn, H. Prostaglandin E2-increased thermosensitivity of anterior hypothalamic neurons is associated with depressed inhibition Proceedings of the National Academy of Sciences of the United States of America  2004 101:2590-2595  DOI:10.1073/pnas.0308718101  PMID:14983053  PMCID:PMC356994
    • Calabrese, B., Tabarean, I. V., Juranka, P., Morris, C. E. Mechanosensitivity of n-type calcium channel currents Biophysical Journal  2002 83:2560-2574  DOI:10.1016/S0006-3495(02)75267-3  PMID:12414690  PMCID:PMC1302342
    • Tabarean, I. V., Morris, C. E. Membrane stretch accelerates activation and slow inactivation in shaker channels with s3-s4 linker deletions Biophysical Journal  2002 82:2982-2994  DOI:10.1016/S0006-3495(02)75639-7  PMID:12023221  PMCID:PMC1302086
    • Tabarean, I. V., Narahashi, T. Kinetics of modulation of tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels by tetramethrin and deltamethrin Journal of Pharmacology and Experimental Therapeutics  2001 299:988-997  PMID:11714887
    • Tabarean, I. V., Juranka, P., Morris, C. E. Membrane stretch affects gating modes of a skeletal muscle sodium channel Biophysical Journal  1999 77:758-774  DOI:10.1016/S0006-3495(99)76930-4  PMID:10423424  PMCID:PMC1300370
    • Mellor, I. R., Miller, B. A., Petrov, A. G., Tabarean, I., Usherwood, P. N. R. Mechanosensitive potassium channels in locust muscle membrane European Biophysics Journal with Biophysics Letters  1999 28:346-350  DOI:10.1007/s002490050217
    • Tabarean, I. V., Narahashi, T. Potent modulation of tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels by the type ii pyrethroid deltamethrin Journal of Pharmacology and Experimental Therapeutics  1998 284:958-965  PMID:9495855

featured in

  • Scripps Research Scientists Find New Link Between Insulin and Core Body Temperature  News Release
  • Scripps Research Team Discovers a Chemical Pathway that Causes Mice to Overeat and Gain Weight  News Release
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Research

research overview

  • The main theme of my research is defining the cellular and molecular signaling mechanisms involved in the central regulation of thermoregulation, fever and energy expenditure. In mammals, the hypothalamus has long been thought to represent the site of a neural integration that controls the characteristic physiologic changes seen during normal thermoregulation or during fever. However, the precise identity of the hypothalamic neurons involved has been unknown. Studies will characterize the neurons involved in these networks and explore the modes of neural signaling responsible for the generation of the physiological changes seen in normal thermoregulation and during fever. We use electrophysiological and optical techniques to measure ion currents and to record changes in intracellular calcium within single neurons, as well as immunocytochemistry and single cell RT/PCR. Current research efforts focus on histamine signaling in the preoptic area/ anterior hypothalamus and its role in thermoregulation and energy expenditure. Histamine exerts an important modulating action on these functions. Lowered hypothalamic histamine concentrations result in lower core body temperature and obesity. Conversely, pharmacological agents that increase hypothalamic histamine concentrations  are beneficial in animal models of diabetes, obesity and an increase body temperature. Other goals of my research are to identify the mechanisms underlying thermosensitive firing activity in anterior hypothalamic neurons and to study cryogen (substances that lower core body temperature) signaling in the hypothalamus.
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Contact

full name

  • Iustin V. Tabarean

geographic location

  • Scripps California 

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