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Stowers, Lisa
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Stowers, Lisa

Faculty Member
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Positions

  • 2017 - Professor, Neuroscience , Scripps Research
  • 2016 - Associate Professor (tenured) (Joint Appointment), Dorris Neuroscience Center , Scripps Research
  • 2007 - Member, The Skaggs Institute for Chemical Biology , Scripps Research
  • 2002 - Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
  • 2016 - 2017 Professor, Molecular and Cellular Neuroscience (MCN) , Scripps Research
  • 2016 Associate Professor (tenured), Molecular and Cellular Neuroscience (MCN) , Scripps Research
  • 2013 - 2016 Associate Professor, Molecular and Cellular Neuroscience (MCN) , Scripps Research
  • 2002 - 2016 Associate Professor (Joint Appointment), Dorris Neuroscience Center , Scripps Research
  • 2002 - 2012 Associate Professor, Cell Biology , Scripps Research
Dr. Lisa Stowers studies the ligands, neurons, and brain nuclei that initiate social behavior using molecular genetics and genomics; her work is determining the rules that generate the information coding of neuronal networks.

Research Areas research areas

  • Mental Illness (UMLS)

Contact

  • stowers@scripps.edu

Websites

  • Lisa Stowers, Ph.D.
  • Laboratory Website
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Publications

recent publications
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  • Publications without PubMed PMIDs

  • academic article

    • Mukhopadhyay, S., Stowers, L. Choosing to urinate. Circuits and mechanisms underlying voluntary urination Current Opinion in Neurobiology  2020 60:129-135  DOI:10.1016/j.conb.2019.11.004  PMID:31875530  PMCID:PMC7055485
    • Marshall, K. L., Saade, D., Ghitani, N., Coombs, A. M., Szczot, M., Keller, J., Ogata, T., Daou, I., Stowers, L., Bonnemann, C. G., Chesler, A. T., Patapoutian, A. PIEZO2 in sensory neurons and urothelial cells coordinates urination Nature  2020  DOI:10.1038/s41586-020-2830-7  PMID:33057202
    • Carvalho, V. M. D., Nakahara, T. S., Souza, M. A. D., Cardozo, L. M., Trintinalia, G. Z., Pissinato, L. G., Venancio, J. O., Stowers, L., Papes, F. Representation of Olfactory Information in Organized Active Neural Ensembles in the Hypothalamus Cell Reports  2020 32  DOI:10.1016/j.celrep.2020.108061  PMID:32846119
    • Koblesky, N., Stowers, L. Animal behavior: honesty can kill Current Biology  2019 29:R259-R261  DOI:10.1016/j.cub.2019.02.002  PMID:30939312
    • Keller, J. A., Chen, J., Simpson, S., Wang, E. H. J., Lilascharoen, V., George, O., Lim, B. K., Stowers, L. Voluntary urination control by brainstem neurons that relax the urethral sphincter Nature Neuroscience  2018 21:1229-1238  DOI:10.1038/s41593-018-0204-3  PMID:30104734  PMCID:PMC6119086
    • Mukhopadhyay, S., Stowers, L. Social behavior: how the brain thinks like a mom Current Biology  2018 28:R746-R749  DOI:10.1016/j.cub.2018.05.049  PMID:29990458
    • Schoeller, E. L., Clark, D. D., Dey, S., Cao, N. V., Semaan, S. J., Chao, L. W., Kauffman, A. S., Stowers, L., Mellon, P. L. Bmal1 is required for normal reproductive behaviors in male mice Endocrinology  2016 157:4914-4929  DOI:10.1210/en.2016-1620  PMID:27704948  PMCID:PMC5133342
    • Dey, S., Stowers, L. Think You Know How Smell Works? Sniff Again Cell  2016 165:1566-1567  DOI:10.1016/j.cell.2016.06.006  PMID:27315472
    • Stowers, L., Liberles, S. D. State-dependent responses to sex pheromones in mouse Current Opinion in Neurobiology  2016 38:74-79  DOI:10.1016/j.conb.2016.04.001  PMID:27093585  PMCID:PMC4921285
    • Stowers, L., Kuo, T. H. Mammalian pheromones: emerging properties and mechanisms of detection Current Opinion in Neurobiology  2015 34:103-109  DOI:10.1016/j.conb.2015.02.005  PMID:25747731  PMCID:PMC4561034
    • Dey, S., Chamero, P., Pru, J. K., Chien, M. S., Ibarra-Soria, X., Spencer, K. R., Logan, D. W., Matsunami, H., Peluso, J. J., Stowers, L. Cyclic regulation of sensory perception by a female hormone alters behavior Cell  2015 161:1334-1344  DOI:10.1016/j.cell.2015.04.052  PMID:26046438  PMCID:PMC4501503
    • Kaur, A. W., Ackels, T., Kuo, T. H., Cichy, A., Dey, S., Hays, C., Kateri, M., Logan, D. W., Marton, T. F., Spehr, M., Stowers, L. Murine pheromone proteins constitute a context-dependent combinatorial code governing multiple social behaviors Cell  2014 157:676-688  DOI:10.1016/j.cell.2014.02.025  PMID:24766811  PMCID:PMC4051225
    • Stowers, L., Cameron, P., Keller, J. A. Ominous odors: olfactory control of instinctive fear and aggression in mice Current Opinion in Neurobiology  2013 23:339-345  DOI:10.1016/j.conb.2013.01.007  PMID:23415829  PMCID:PMC3661762
    • Li, Q., Korzan, W. J., Ferrero, D. M., Chang, R. B., Roy, D. S., Buchi, M., Lemon, J. K., Kaur, A. W., Stowers, L., Fendt, M., Liberles, S. D. Synchronous evolution of an odor biosynthesis pathway and behavioral response Current Biology  2013 23:11-20  DOI:10.1016/j.cub.2012.10.047  PMID:23177478  PMCID:PMC3543494
    • Kaur, A., Dey, S., Stowers, L. Live cell calcium imaging of dissociated vomeronasal neurons Methods in Molecular Biology  2013 1068:189-200  DOI:10.1007/978-1-62703-619-1_13  PMID:24014362
    • Logan, D. W., Brunet, L. J., Webb, W. R., Cutforth, T., Ngai, J., Stowers, L. Learned recognition of maternal signature odors mediates the first suckling episode in mice Current Biology  2012 22:1998-2007  DOI:10.1016/j.cub.2012.08.041  PMID:23041191  PMCID:PMC3494771
    • Flanagan, K. A., Webb, W., Stowers, L. Analysis of male pheromones that accelerate female reproductive organ development PLoS One  2011 6:e16660  DOI:10.1371/journal.pone.0016660  PMID:21347429  PMCID:PMC3035649
    • Stowers, L., Logan, D. W. Sexual dimorphism in olfactory signaling Current Opinion in Neurobiology  2010 20:770-775  DOI:10.1016/j.conb.2010.08.015  PMID:20833534  PMCID:PMC3005963
    • Stowers, L., Logan, D. W. Olfactory mechanisms of stereotyped behavior: On the scent of specialized circuits Current Opinion in Neurobiology  2010 20:274-280  DOI:10.1016/j.conb.2010.02.013  PMID:20338743  PMCID:PMC2883022
    • Papes, F., Logan, D. W., Stowers, L. The vomeronasal organ mediates interspecies defensive behaviors through detection of protein pheromone homologs Cell  2010 141:692-703  DOI:10.1016/j.cell.2010.03.037  PMID:20478258  PMCID:PMC2873972
    • Barros, C. S., Calabrese, B., Chamero, P., Roberts, A. J., Korzus, E., Lloyd, K., Stowers, L., Mayford, M., Halpain, S., Muller, U. Impaired maturation of dendritic spines without disorganization of cortical cell layers in mice lacking NRG1/ErbB signaling in the central nervous system Proceedings of the National Academy of Sciences of the United States of America  2009 106:4507-4512  DOI:10.1073/pnas.0900355106  PMID:19240213  PMCID:PMC2657442
    • Wilson, D. A., Baker, H., Brunjes, P., Gilbertson, T. A., Hermer, L., Hill, D. L., Matsunami, H., Meredith, M., Mistretta, C. M., Smeets, M. A. M., Stowers, L., Zhuang, H. Y. Chemoreception scientists gather under the florida sun: The 31st annual association for chemoreception sciences meeting Annals of the New York Academy of Sciences  2009 1170:1-11  DOI:10.1111/j.1749-6632.2009.05047.x  PMID:19712224  PMCID:PMC2873611
    • Logan, D. W., Marton, T. F., Stowers, L. Species specificity in major urinary proteins by parallel evolution PLoS One  2008 3:e3280  DOI:10.1371/journal.pone.0003280  PMID:18815613  PMCID:PMC2533699
    • Chamero, P., Marton, T. F., Logan, D. W., Flanagan, K., Cruz, J. R., Saghatelian, A., Cravatt, B. F., Stowers, L. Identification of protein pheromones that promote aggressive behaviour Nature  2007 450:899-902  DOI:10.1038/nature05997  PMID:18064011
    • Stowers, L., Marton, T. F. What is a pheromone? Mammalian pheromones reconsidered. Neuron  2005 46:699-702  DOI:10.1016/j.neuron.2005.04.032  PMID:15924856
    • Loconto, J., Papes, F., Chang, E., Stowers, L., Jones, E. P., Takada, T., Kumanovics, A., Lindahl, K. F., Dulac, C. Functional expression of murine v213 pheromone receptors involves selective association with the m10 and m1 families of mhc class ib molecules Cell  2003 112:607-618  DOI:10.1016/s0092-8674(03)00153-3  PMID:12628182
    • Stowers, L., Holy, T. E., Meister, M., Dulac, C., Koentges, G. Loss of sex discrimination and male-male aggression in mice deficient for trp2 Science  2002 295:1493-1500  DOI:10.1126/science.1069259  PMID:11823606
    • Lamarche, N., Tapon, N., Stowers, L., Burbelo, P. D., Aspenstrom, P., Bridges, T., Chant, J., Hall, A. Rac and cdc42 induce actin polymerization and g1 cell cycle progression independently of p65(pak) and the jnk/sapk map kinase cascade Cell  1996 87:519-529  DOI:10.1016/s0092-8674(00)81371-9  PMID:8898204
    • Brown, J. L., Stowers, L., Baer, M., Trejo, J., Coughlin, S., Chant, J. Human ste20 homologue hpak1 links gtpases to the jnk map kinase pathway Current Biology  1996 6:598-605  DOI:10.1016/s0960-9822(02)00546-8  PMID:8805275
    • Stowers, L., Yelon, D., Berg, L. J., Chant, J. Regulation of the polarization of t-cells toward antigen-presenting cells by ras-related gtpase cdc42 Proceedings of the National Academy of Sciences of the United States of America  1995 92:5027-5031  DOI:10.1073/pnas.92.11.5027  PMID:7761442
    • Chant, J., Stowers, L. GTPase cascades choreographing cellular behavior: movement, morphogenesis, and more Cell  1995 81:1-4  DOI:10.1016/0092-8674(95)90363-1  PMID:7720065
    • Stowers, L., Herrnstadt, C., Grothe, A., Pease, E., Osterlund, M., Cable, P., Brolaski, M., Gautsch, J. Rapid isolation of plasmid DNA American Biotechnology Laboratory  1992 10:48-48

featured in

  • Scripps Research Institute Dedicates Dorris Neuroscience Center  News Release
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Research

research overview

  • How Neurons Detect and Respond to Pheromones

    We are using a molecular approach to identify how neurons function to generate complex mammalian behavior.

    A male mouse listens and sniffs as an animal enters his territory. His sensory systems reveal that it is another mouse, but what is the appropriate behavioral response? He should be defensive only if the intruder is male. Over the past year, we have determined that pheromone cues released from the other mouse act through the vomeronasal organ (VNO) to ensure that appropriate social interactions, including territorial aggression and mating behaviors, are executed without error. Interestingly, the odd confluence of phenotypes we have observed in pheromone response mutants is remarkably similar to human Kluver-Bucy syndrome. This suggests that the central nervous system encodes behavioral information similarly in both humans and mice.

    How does the brain recognize environmental stimuli and initiate an appropriate response? What molecules generate these impulses? Which neuronal circuits activate social behavior? We are using mouse molecular genetic techniques, histological, electrophysiological, and behavioral analysis to address these questions and are uncovering surprising information about neuronal coding.

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Teaching

advisees

  • graduate advising relationship

    • Chen, Jingyi, Ph.D.  candidate, 2016 -
    • Mukhopadhyay, Sourish, Ph.D.  candidate, 2017 -
    • Kaur, Angeldeep, Ph.D.  candidate, 2008 - 2012
    • Flanagan, Kelly, Ph.D.  candidate, 2005 - 2010
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Background

education and training

  • Ph.D. in Molecular & Cellular Biology, Harvard University 1997
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Contact

full name

  • Lisa Stowers

geographic location

  • Scripps California 

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