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Srinivasan, Supriya
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Srinivasan, Supriya

Faculty Member
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Positions

  • 2018 - Associate Professor Tenure (Joint Appointment), Neuroscience , Scripps Research
  • 2018 - Associate Professor Tenure, Molecular Medicine , Scripps Research
  • 2010 - Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
  • 2010 - Assistant Professor (Joint Appointment), Dorris Neuroscience Center , Scripps Research
  • 2017 - 2018 Assistant Professor (Joint Appointment), Neuroscience , Scripps Research
  • 2017 - 2018 Assistant Professor, Molecular Medicine , Scripps Research
  • 2013 - 2017 Assistant Professor (Joint Appointment), Molecular and Cellular Neuroscience (MCN) , Scripps Research
  • 2010 - 2017 Assistant Professor (Joint Appointment), Molecular and Experimental Medicine (MEM) , Scripps Research
  • 2010 - 2017 Assistant Professor , Chemical Physiology , Scripps Research
  • 2005 - 2009 Postdoctoral Fellow with Dr. Kaveh Ashrafi and Dr. Keith Yamamoto, University of California, San Francisco
  • 2001 - 2005 Postdoctoral Fellow with Dr. Bruce Conklin, The Gladstone Institute of Cardiovascular Disease , Gladstone Institutes
Dr. Supriya Srinivasan studies the relative contributions of genetic, behavioral and environmental influences to adaptive homeostatic properties such as energy balance; she uses C. elegans as a model system to perform large-scale screens followed by characterization of molecular, genetic and neuroendocrine networks to identify new strategies for the management of human disorders including metabolic syndrome, obesity and accelerated aging.

Research Areas research areas

  • Aging (UMLS)
  • Mental Illness (UMLS)

Contact

  • supriya@scripps.edu

Websites

  • Supriya Srinivasan, Ph.D.
  • Laboratory Website
  • Publications
  • Research
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Publications

recent publications
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  • academic article

    • Fanning, S., Haque, A., Imberdis, T., Baru, V., Barrasa, M. I., Nuber, S., Termine, D., Ramalingam, N., Ho, G. P. H., Noble, T., Sandoe, J., Lou, Y., et al. Lipidomic analysis of α-synuclein neurotoxicity identifies stearoyl CoA desaturase as a target for parkinson treatment Molecular Cell  2019 73:1001-1014  DOI:10.1016/j.molcel.2018.11.028  PMID:30527540  PMCID:PMC6408259
    • Kok, B. P., Galmozzi, A., Littlejohn, N. K., Albert, V., Godio, C., Kim, W., Kim, S. M., Bland, J. S., Grayson, N., Fang, M. L., Meyerhof, W., Siuzdak, G., et al. Intestinal bitter taste receptor activation alters hormone secretion and imparts metabolic benefits Molecular Metabolism  2018 16:76-87  DOI:10.1016/j.molmet.2018.07.013  PMID:30120064  PMCID:PMC6158035
    • Hussey, R., Littlejohn, N. K., Witham, E., Vanstrum, E., Mesgarzadeh, J., Ratanpal, H., Srinivasan, S. Oxygen-sensing neurons reciprocally regulate peripheral lipid metabolism via neuropeptide signaling in Caenorhabditis elegans PLoS Genetics  2018 14  DOI:10.1371/journal.pgen.1007305  PMID:29579048
    • Palamiuc, L., Noble, T., Witham, E., Ratanpal, H., Vaughan, M., Srinivasan, S. A tachykinin-like neuroendocrine signalling axis couples central serotonin action and nutrient sensing with peripheral lipid metabolism Nature Communications  2017 8  DOI:10.1038/ncomms14237  PMID:28128367  PMCID:PMC5290170
    • Hussey, R., Stieglitz, J., Mesgarzadeh, J., Locke, T. T., Zhang, Y. K., Schroeder, F. C., Srinivasan, S. Pheromone-sensing neurons regulate peripheral lipid metabolism in Caenorhabditis elegans PLoS Genetics  2017 13  DOI:10.1371/journal.pgen.1006806  PMID:28545126  PMCID:PMC5456406
    • Witham, E., Comunian, C., Ratanpal, H., Skora, S., Zimmer, M., Srinivasan, S. C-elegans body cavity neurons are homeostatic sensors that integrate fluctuations in oxygen availability and internal nutrient reserves Cell Reports  2016 14:1641-1654  DOI:10.1016/j.celrep.2016.01.052  PMID:26876168  PMCID:PMC4767172
    • Auerbach, S., Filer, D., Reif, D., Walker, V., Holloway, A. C., Schlezinger, J., Srinivasan, S., Svoboda, D., Judson, R., Bucher, J. R., Thayer, K. A. Prioritizing environmental chemicals for obesity and diabetes outcomes research: a screening approach using ToxCast™ high-throughput data Environmental Health Perspectives  2016 124:1141-1154  DOI:10.1289/ehp.1510456  PMID:26978842  PMCID:PMC4977057
    • Srinivasan, S. Regulation of body fat in Caenorhabditis elegans Annual Review of Physiology  2015 77:161-178  DOI:10.1146/annurev-physiol-021014-071704  PMID:25340962  PMCID:PMC4766980
    • Noble, T., Stieglitz, J., Srinivasan, S. An integrated serotonin and octopamine neuronal circuit directs the release of an endocrine signal to control C. elegans body fat Cell Metabolism  2013 18:672-684  DOI:10.1016/j.cmet.2013.09.007  PMID:24120942  PMCID:PMC3882029
    • Behl, M., Rao, D., Aagaard, K., Davidson, T. L., Levin, E. D., Slotkin, T. A., Srinivasan, S., Wallinga, D., White, M. F., Walker, V. R., Thayer, K. A., Holloway, A. C. Evaluation of the association between maternal smoking, childhood obesity, and metabolic disorders: a national toxicology program workshop review Environmental Health Perspectives  2013 121:170-180  DOI:10.1289/ehp.1205404  PMID:23232494  PMCID:PMC3569686
    • Cunningham, K. A., Hua, Z. L., Srinivasan, S., Liu, J., Lee, B. H., Edwards, R. H., Ashrafi, K. Amp-activated kinase links serotonergic signaling to glutamate release for regulation of feeding behavior in c. Elegans Cell Metabolism  2012 16:113-121  DOI:10.1016/j.cmet.2012.05.014  PMID:22768843  PMCID:PMC3413480
    • Lee, B. H., Liu, J., Wong, D., Srinivasan, S., Ashrafi, K. Hyperactive neuroendocrine secretion causes size, feeding, and metabolic defects of c. Elegans bardet-biedl syndrome mutants PLoS Biology  2011 9:e1001219  DOI:10.1371/journal.pbio.1001219  PMID:22180729  PMCID:PMC3236739
    • Conklin, B. R., Hsiao, E. C., Claeysen, S., Dumuis, A., Srinivasan, S., Forsayeth, J. R., Guettier, J. M., Chang, W. C., Pei, Y., McCarthy, K. D., Nissenson, R. A., Wess, J., et al. Engineering GPCR signaling pathways with RASSLs Nature Methods  2008 5:673-678  DOI:10.1038/nmeth.1232  PMID:18668035  PMCID:PMC2703467
    • Srinivasan, S., Sadegh, L., Elle, I. C., Christensen, A. G. L., Faergeman, N. J., Ashrafi, K. Serotonin regulates c-elegans fat and feeding through independent molecular mechanisms Cell Metabolism  2008 7:533-544  DOI:10.1016/j.cmet.2008.04.012  PMID:18522834  PMCID:PMC2495008
    • Srinivasan, S., Santiago, P., Lubrano, C., Vaisse, C., Conklin, B. R. Engineering the melanocortin-4 receptor to control constitutive and ligand-mediated g(s) signaling in vivo PLoS One  2007 2:e668  DOI:10.1371/journal.pone.0000668  PMID:17668051  PMCID:PMC1930153
    • Govaerts, C., Srinivasan, S., Shapiro, A., Zhang, S. M., Picard, F., Clement, K., Lubrano-Berthelier, C., Vaisse, C. Obesity-associated mutations in the melanocortin 4 receptor provide novel insights into its function Peptides  2005 26:1909-1919  DOI:10.1016/j.peptides.2004.11.042  PMID:16083993
    • Srinivasan, S., Lubrano-Berthelier, C., Govaerts, C., Picard, F., Santiago, P., Conklin, B. R., Vaisse, C. Constitutive activity of the melanocortin-4 receptor is maintained by its n-terminal domain and plays a role in energy homeostasis in humans Journal of Clinical Investigation  2004 114:1158-1164  DOI:10.1172/jci200421927  PMID:15489963
    • Srinivasan, S., Vaisse, C., Conklin, B. R. Engineering the melanocortin-4 receptor to control G(s) signaling in vivo Annals of the New York Academy of Sciences  2003 994:225-232  PMID:12851320
    • Alexander, S., Srinivasan, S., Alexander, H. Proteomics opens doors to the mechanisms of developmentally regulated secretion Molecular & Cellular Proteomics  2003 2:1156-1163  DOI:10.1074/mcp.R300011-MCP200  PMID:14504294
    • Srinivasan, S., Traini, M., Herbert, B., Sexton, D., Harry, J., Alexander, H., Williams, K. L., Alexander, S. Proteomic analysis of a developmentally regulated secretory vesicle Proteomics  2001 1:1119-1127  DOI:10.1002/1615-9861(200109)1:9<1119::aid-prot1119>3.3.co;2-o  PMID:11990506
    • Srinivasan, S., Alexander, H., Alexander, S. Crossing the finish line of development: regulated secretion of Dictyostelium proteins Trends in Cell Biology  2000 10:215-219  DOI:10.1016/s0962-8924(00)01758-x  PMID:10802536
    • Mreyen, M., Champion, A., Srinivasan, S., Karuso, P., Williams, K. L., Packer, N. H. Multiple o-glycoforms on the spore coat protein sp96 in dictyostelium discoideum - fuc(alpha 1-3)glcnac-alpha-1-p-ser is the major modification Journal of Biological Chemistry  2000 275:12164-12174  DOI:10.1074/jbc.275.16.12164  PMID:10766852
    • Srinivasan, S., Alexander, H., Alexander, S. The Dictyostelium fruiting body - a structure of cells and cellulose Trends in Cell Biology  2000 10:315-315  DOI:10.1016/s0962-8924(00)01775-x
    • Srinivasan, S., Griffiths, K. R., McGuire, V., Champion, A., Williams, K. L., Alexander, S. The cellulose-binding activity of the PsB multiprotein complex is required for proper assembly of the spore coat and spore viability in Dictyostelium discoideum Microbiology  2000 146:1829-1839  PMID:10931888
    • Srinivasan, S., Alexander, H., Alexander, S. The prespore vesicles of dictyostelium discoideum - purification, characterization, and developmental regulation Journal of Biological Chemistry  1999 274:35823-35831  DOI:10.1074/jbc.274.50.35823  PMID:10585466

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Research

research overview

  • Laboratory of Molecular Physiology and Chemical Genetics

    Our laboratory is interested in understanding emergent properties of complex biological networks at a molecular level. Specifically, we are interested in determining how adaptive homeostatic or allostatic properties such as energy balance and metabolic set points arise in complex multicellular animals, and in the multitude of extrinsic and intrinsic parameters that influence such properties during the lifespan of an animal. Implicit in our studies is the goal of finding new preventive and therapeutic strategies for human diseases of allostatic dysregulation such as obesity and accelerated aging.

    We employ the nematode C. elegans for our studies, an ideal model for systems-level analyses of energy balance networks and metabolic set-point regulation. We utilize a multidisciplinary approach using chemical biology, molecular genetics, proteomics and lipid profiling, pharmacology and neuroscience. The power of the C. elegans system allows the rapid discovery of new pathways that connect sensory function in the nervous system and other tissues, to metabolic actions in the periphery. Novel and conserved molecular candidates emerging from these studies will be tested in mammalian models. Our long-term goal is to understand the relative contributions of genetic, behavioral and environmental influences on complex physiological phenotypes.

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Teaching

advisees

  • graduate advising relationship

    • Vaughan, Megan, Ph.D.  candidate, 2015 -
    • Zhang, Yorke, Ph.D.  candidate, 2013 -
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Background

education and training

  • Ph.D. in Genetics, University of Missouri-Columbia , Division of Biological Sciences, with Dr. Stephen Alexander 1996 - 2000
  • B.Sc. (Hons) Bachelor of Science in Biology, Macquarie University 1996

awards and honors

  • National Institutes of Health
  • American Heart Association
  • Ellison Medical Foundation/American Federation for Aging Research
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Contact

full name

  • Supriya Srinivasan

geographic location

  • Scripps California 

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