recent publications
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academic article
- Fanning, S., Haque, A., Imberdis, T., Baru, V., Barrasa, M. I., Nuber, S., Termine, D., Ramalingam, N., Ho, G. P. H., Noble, T., Sandoe, J., Lou, Y., et al. Lipidomic analysis of α-synuclein neurotoxicity identifies stearoyl CoA desaturase as a target for parkinson treatment Molecular Cell 2019 73:1001-1014 DOI:10.1016/j.molcel.2018.11.028 PMID:30527540 PMCID:PMC6408259
- Kok, B. P., Galmozzi, A., Littlejohn, N. K., Albert, V., Godio, C., Kim, W., Kim, S. M., Bland, J. S., Grayson, N., Fang, M. L., Meyerhof, W., Siuzdak, G., et al. Intestinal bitter taste receptor activation alters hormone secretion and imparts metabolic benefits Molecular Metabolism 2018 16:76-87 DOI:10.1016/j.molmet.2018.07.013 PMID:30120064 PMCID:PMC6158035
- Hussey, R., Littlejohn, N. K., Witham, E., Vanstrum, E., Mesgarzadeh, J., Ratanpal, H., Srinivasan, S. Oxygen-sensing neurons reciprocally regulate peripheral lipid metabolism via neuropeptide signaling in Caenorhabditis elegans PLoS Genetics 2018 14 DOI:10.1371/journal.pgen.1007305 PMID:29579048
- Palamiuc, L., Noble, T., Witham, E., Ratanpal, H., Vaughan, M., Srinivasan, S. A tachykinin-like neuroendocrine signalling axis couples central serotonin action and nutrient sensing with peripheral lipid metabolism Nature Communications 2017 8 DOI:10.1038/ncomms14237 PMID:28128367 PMCID:PMC5290170
- Hussey, R., Stieglitz, J., Mesgarzadeh, J., Locke, T. T., Zhang, Y. K., Schroeder, F. C., Srinivasan, S. Pheromone-sensing neurons regulate peripheral lipid metabolism in Caenorhabditis elegans PLoS Genetics 2017 13 DOI:10.1371/journal.pgen.1006806 PMID:28545126 PMCID:PMC5456406
- Witham, E., Comunian, C., Ratanpal, H., Skora, S., Zimmer, M., Srinivasan, S. C-elegans body cavity neurons are homeostatic sensors that integrate fluctuations in oxygen availability and internal nutrient reserves Cell Reports 2016 14:1641-1654 DOI:10.1016/j.celrep.2016.01.052 PMID:26876168 PMCID:PMC4767172
- Auerbach, S., Filer, D., Reif, D., Walker, V., Holloway, A. C., Schlezinger, J., Srinivasan, S., Svoboda, D., Judson, R., Bucher, J. R., Thayer, K. A. Prioritizing environmental chemicals for obesity and diabetes outcomes research: a screening approach using ToxCast™ high-throughput data Environmental Health Perspectives 2016 124:1141-1154 DOI:10.1289/ehp.1510456 PMID:26978842 PMCID:PMC4977057
- Srinivasan, S. Regulation of body fat in Caenorhabditis elegans Annual Review of Physiology 2015 77:161-178 DOI:10.1146/annurev-physiol-021014-071704 PMID:25340962 PMCID:PMC4766980
- Noble, T., Stieglitz, J., Srinivasan, S. An integrated serotonin and octopamine neuronal circuit directs the release of an endocrine signal to control C. elegans body fat Cell Metabolism 2013 18:672-684 DOI:10.1016/j.cmet.2013.09.007 PMID:24120942 PMCID:PMC3882029
- Behl, M., Rao, D., Aagaard, K., Davidson, T. L., Levin, E. D., Slotkin, T. A., Srinivasan, S., Wallinga, D., White, M. F., Walker, V. R., Thayer, K. A., Holloway, A. C. Evaluation of the association between maternal smoking, childhood obesity, and metabolic disorders: a national toxicology program workshop review Environmental Health Perspectives 2013 121:170-180 DOI:10.1289/ehp.1205404 PMID:23232494 PMCID:PMC3569686
- Cunningham, K. A., Hua, Z. L., Srinivasan, S., Liu, J., Lee, B. H., Edwards, R. H., Ashrafi, K. Amp-activated kinase links serotonergic signaling to glutamate release for regulation of feeding behavior in c. Elegans Cell Metabolism 2012 16:113-121 DOI:10.1016/j.cmet.2012.05.014 PMID:22768843 PMCID:PMC3413480
- Lee, B. H., Liu, J., Wong, D., Srinivasan, S., Ashrafi, K. Hyperactive neuroendocrine secretion causes size, feeding, and metabolic defects of c. Elegans bardet-biedl syndrome mutants PLoS Biology 2011 9:e1001219 DOI:10.1371/journal.pbio.1001219 PMID:22180729 PMCID:PMC3236739
- Conklin, B. R., Hsiao, E. C., Claeysen, S., Dumuis, A., Srinivasan, S., Forsayeth, J. R., Guettier, J. M., Chang, W. C., Pei, Y., McCarthy, K. D., Nissenson, R. A., Wess, J., et al. Engineering GPCR signaling pathways with RASSLs Nature Methods 2008 5:673-678 DOI:10.1038/nmeth.1232 PMID:18668035 PMCID:PMC2703467
- Srinivasan, S., Sadegh, L., Elle, I. C., Christensen, A. G. L., Faergeman, N. J., Ashrafi, K. Serotonin regulates c-elegans fat and feeding through independent molecular mechanisms Cell Metabolism 2008 7:533-544 DOI:10.1016/j.cmet.2008.04.012 PMID:18522834 PMCID:PMC2495008
- Srinivasan, S., Santiago, P., Lubrano, C., Vaisse, C., Conklin, B. R. Engineering the melanocortin-4 receptor to control constitutive and ligand-mediated g(s) signaling in vivo PLoS One 2007 2:e668 DOI:10.1371/journal.pone.0000668 PMID:17668051 PMCID:PMC1930153
- Govaerts, C., Srinivasan, S., Shapiro, A., Zhang, S. M., Picard, F., Clement, K., Lubrano-Berthelier, C., Vaisse, C. Obesity-associated mutations in the melanocortin 4 receptor provide novel insights into its function Peptides 2005 26:1909-1919 DOI:10.1016/j.peptides.2004.11.042 PMID:16083993
- Srinivasan, S., Lubrano-Berthelier, C., Govaerts, C., Picard, F., Santiago, P., Conklin, B. R., Vaisse, C. Constitutive activity of the melanocortin-4 receptor is maintained by its n-terminal domain and plays a role in energy homeostasis in humans Journal of Clinical Investigation 2004 114:1158-1164 DOI:10.1172/jci200421927 PMID:15489963
- Srinivasan, S., Vaisse, C., Conklin, B. R. Engineering the melanocortin-4 receptor to control G(s) signaling in vivo Annals of the New York Academy of Sciences 2003 994:225-232 PMID:12851320
- Alexander, S., Srinivasan, S., Alexander, H. Proteomics opens doors to the mechanisms of developmentally regulated secretion Molecular & Cellular Proteomics 2003 2:1156-1163 DOI:10.1074/mcp.R300011-MCP200 PMID:14504294
- Srinivasan, S., Traini, M., Herbert, B., Sexton, D., Harry, J., Alexander, H., Williams, K. L., Alexander, S. Proteomic analysis of a developmentally regulated secretory vesicle Proteomics 2001 1:1119-1127 DOI:10.1002/1615-9861(200109)1:9<1119::aid-prot1119>3.3.co;2-o PMID:11990506
- Srinivasan, S., Alexander, H., Alexander, S. Crossing the finish line of development: regulated secretion of Dictyostelium proteins Trends in Cell Biology 2000 10:215-219 DOI:10.1016/s0962-8924(00)01758-x PMID:10802536
- Mreyen, M., Champion, A., Srinivasan, S., Karuso, P., Williams, K. L., Packer, N. H. Multiple o-glycoforms on the spore coat protein sp96 in dictyostelium discoideum - fuc(alpha 1-3)glcnac-alpha-1-p-ser is the major modification Journal of Biological Chemistry 2000 275:12164-12174 DOI:10.1074/jbc.275.16.12164 PMID:10766852
- Srinivasan, S., Alexander, H., Alexander, S. The Dictyostelium fruiting body - a structure of cells and cellulose Trends in Cell Biology 2000 10:315-315 DOI:10.1016/s0962-8924(00)01775-x
- Srinivasan, S., Griffiths, K. R., McGuire, V., Champion, A., Williams, K. L., Alexander, S. The cellulose-binding activity of the PsB multiprotein complex is required for proper assembly of the spore coat and spore viability in Dictyostelium discoideum Microbiology 2000 146:1829-1839 PMID:10931888
- Srinivasan, S., Alexander, H., Alexander, S. The prespore vesicles of dictyostelium discoideum - purification, characterization, and developmental regulation Journal of Biological Chemistry 1999 274:35823-35831 DOI:10.1074/jbc.274.50.35823 PMID:10585466