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Speers, Anna

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  • Chang, J. W., Zuhl, A. M., Speers, A. E., Niessen, S., Brown, S. J., Mulvihill, M. M., Fan, Y. C., Spicer, T. P., Southern, M., Scampavia, L., Fernandez-Vega, V., Dix, M. M., et al. Selective inhibitor of platelet-activating factor acetylhydrolases 1b2 and 1b3 that impairs cancer cell survival ACS Chemical Biology  2015 10:925-932  DOI:10.1021/cb500893q  PMID:25602368  PMCID:PMC4402257
  • Zhao, N., Darby, C. M., Small, J., Bachovchin, D. A., Jiang, X., Burns-Huang, K. E., Botella, H., Ehrt, S., Boger, D. L., Anderson, E. D., Cravatt, B. F., Speers, A. E., et al. Target-based screen against a periplasmic serine protease that regulates intrabacterial pH homeostasis in Mycobacterium tuberculosis ACS Chemical Biology  2015 10:364-371  DOI:10.1021/cb500746z  PMID:25457457  PMCID:PMC4340348
  • Ward, J., Spath, S. N., Pabst, B., Carpino, P. A., Ruggeri, R. B., Xing, G., Speers, A. E., Cravatt, B. F., Ahn, K. Mechanistic characterization of a 2-thioxanthine myeloperoxidase inhibitor and selectivity assessment utilizing click chemistry-activity-based protein profiling Biochemistry  2013 52:9187-9201  DOI:10.1021/bi401354d  PMID:24320749
  • Hsu, K. L., Tsuboi, K., Whitby, L. R., Speers, A. E., Pugh, H., Inloes, J., Cravatt, B. F. Development and optimization of piperidyl-1,2,3-triazole ureas as selective chemical probes of endocannabinoid biosynthesis Journal of Medicinal Chemistry  2013 56:8257-8269  DOI:10.1021/jm400898x  PMID:24152245  PMCID:PMC3984011
  • Hsu, K. L., Tsuboi, K., Chang, J. W., Whitby, L. R., Speers, A. E., Pugh, H., Cravatt, B. F. Discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of α/β-hydrolase domain containing 6 (ABHD6) Journal of Medicinal Chemistry  2013 56:8270-8279  DOI:10.1021/jm400899c  PMID:24152295  PMCID:PMC3987869
  • Nagano, J. M. G., Hsu, K. L., Whitby, L. R., Niphakis, M. J., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Hodder, P., Srinivasan, P., Gonzalez, T. D., et al. Selective inhibitors and tailored activity probes for lipoprotein-associated phospholipase A(2) Bioorganic & Medicinal Chemistry Letters  2013 23:839-843  DOI:10.1016/j.bmcl.2012.11.061  PMID:23260346  PMCID:PMC3549684
  • Liu, X. D., Dix, M., Speers, A. E., Bachovchin, D. A., Zuhl, A. M., Cravatt, B. F., Kodadek, T. J. Rapid development of a potent photo-triggered inhibitor of the serine hydrolase RBBP9 ChemBioChem  2012 13:2082-2093  DOI:10.1002/cbic.201200445  PMID:22907802  PMCID:PMC3777423
  • Adibekian, A., Martin, B. R., Chang, J. W., Hsu, K. L., Tsuboi, K., Bachovchin, D. A., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Hodder, P. S., et al. Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probes Journal of the American Chemical Society  2012 134:10345-10348  DOI:10.1021/ja303400u  PMID:22690931  PMCID:PMC3392194
  • Saario, S. M., McKinney, M. K., Speers, A. E., Wang, C., Cravatt, B. F. Clickable, photoreactive inhibitors to probe the active site microenvironment of fatty acid amide hydrolase Chemical Science  2012 3:77-83  DOI:10.1039/c1sc00336d  PMID:22737400  PMCID:PMC3378062
  • Rowland, M. M., Bostic, H. E., Gong, D. H., Speers, A. E., Lucas, N., Cho, W. H., Cravatt, B. F., Best, M. D. Phosphatidylinositol 3,4,5-trisphosphate activity probes for the labeling and proteomic characterization of protein binding partners Biochemistry  2011 50:11143-11161  DOI:10.1021/bi201636s  PMID:22074223  PMCID:PMC3649876
  • Tsuboi, K., Bachovchin, D. A., Speers, A. E., Spicer, T. P., Fernandez-Vega, V., Hodder, P., Rosen, H., Cravatt, B. F. Potent and selective inhibitors of glutathione S-transferase omega 1 that impair cancer drug resistance Journal of the American Chemical Society  2011 133:16605-16616  DOI:10.1021/ja2066972  PMID:21899313  PMCID:PMC3226709
  • Lone, A. M., Bachovchin, D. A., Westwood, D. B., Speers, A. E., Spicer, T. P., Fernandez-Vega, V., Chase, P., Hodder, P. S., Rosen, H., Cravatt, B. F., Saghatelian, A. A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors Journal of the American Chemical Society  2011 133:11665-11674  DOI:10.1021/ja2036095  PMID:21692504  PMCID:PMC3145007
  • Bachovchin, D. A., Zuhl, A. M., Speers, A. E., Wolfe, M. R., Weerapana, E., Brown, S. J., Rosen, H., Cravatt, B. F. Discovery and optimization of sulfonyl acrylonitriles as selective, covalent inhibitors of protein phosphatase methylesterase-1 Journal of Medicinal Chemistry  2011 54:5229-5236  DOI:10.1021/jm200502u  PMID:21639134  PMCID:PMC3144155
  • Bachovchin, D. A., Mohr, J. T., Speers, A. E., Wang, C., Berlin, J. M., Spicer, T. P., Fernandez-Vega, V., Chase, P., Hodder, P. S., Schurer, S. C., Nomura, D. K., Rosen, H., et al. Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors Proceedings of the National Academy of Sciences of the United States of America  2011 108:6811-6816  DOI:10.1073/pnas.1015248108  PMID:21398589  PMCID:PMC3084096
  • Speers, A. E., Cravatt, B. F. Ligands in crystal structures that aid in functional characterization Acta Crystallographica Section F-Structural Biology and Crystallization Communications  2010 66:1306-1308  DOI:10.1107/s1744309110035748  PMID:20944226  PMCID:PMC2954220
  • Speers, A. E., Cravatt, B. F. Activity-based protein profiling (ABPP) and click chemistry (CC)-ABPP by MudPIT mass spectrometry Current Protocols in Chemical Biology  2009 1:29-41  DOI:10.1002/9780470559277.ch090138  PMID:21701697  PMCID:PMC3119539
  • Blackler, A. R., Speers, A. E., Wu, C. C. Chromatographic benefits of elevated temperature for the proteomic analysis of membrane proteins Proteomics  2008 8:3956-3964  DOI:10.1002/pmic.200800210  PMID:18780350  PMCID:PMC2765112
  • Blackler, A. R., Speers, A. E., Ladinsky, M. S., Wu, C. C. A shotgun proteomic method for the identification of membrane-embedded proteins and peptides Journal of Proteome Research  2008 7:3028-3034  DOI:10.1021/pr700795f  PMID:18537282  PMCID:PMC2765231
  • Speers, A. E., Wu, C. C. Proteomics of integral membrane proteins-theory and application Chemical Reviews  2007 107:3687-3714  DOI:10.1021/cr068286z  PMID:17683161
  • Speers, A. E., Blackler, A. R., Wu, C. C. Shotgun analysis of integral membrane proteins facilitated by elevated temperature Analytical Chemistry  2007 79:4613-4620  DOI:10.1021/ac0700225  PMID:17500534
  • Weerapana, E., Speers, A. E., Cravatt, B. F. Tandem orthogonal proteolysis-activity-based protein profiling (TOP-ABPP) - a general method for mapping sites of probe modification in proteomes Nature Protocols  2007 2:1414-1425  DOI:10.1038/nprot.2007.194  PMID:17545978
  • Speers, A. E., Cravatt, B. F. A tandem orthogonal proteolysis strategy for high-content chemical proteomics Journal of the American Chemical Society  2005 127:10018-10019  DOI:10.1021/ja0532842  PMID:16011363  PMCID:PMC1538546
  • Speers, A. E., Cravatt, B. F. Profiling enzyme activities in vivo using click chemistry methods Chemistry & Biology  2004 11:535-546  DOI:10.1016/j.chembiol.2004.03.012  PMID:15123248
  • Speers, A. E., Cravatt, B. F. Chemical strategies for activity-based proteomics ChemBioChem  2004 5:41-47  DOI:10.1002/cbic.200300721  PMID:14695510
  • Speers, A. E., Adam, G. C., Cravatt, B. F. Activity-based protein profiling in vivo using a copper(i)-catalyzed azide-alkyne 3+2 cycloaddition Journal of the American Chemical Society  2003 125:4686-4687  DOI:10.1021/ja034490h  PMID:12696868

• report

  • Hulce, J. J., Joslyn, C., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Cravatt, B. F., Hodder, P., Rosen, H. An in vivo active carbamate-based dual inhibitor of lysophospholipase 1 (LYPLA1) and lysophospholipase 2 (LYPLA2) Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:25506974
  • Zuhl, A. M., Mohr, J. T., Speers, A. E., Bachovchin, D. A., Berlin, J. M., Spicer, T., Fernandez-Vega, V., Brown, S. J., Ferguson, J., Fu, G. C., Cravatt, B. F., Hodder, P., et al. Probe development efforts to identify novel inhibitors of ABHD10 Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:23762952
  • Adibekian, A., Martin, B. R., Chang, J. W., Hsu, K. L., Tsuboi, K., Bachovchin, D. A., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Cravatt, B. F., et al. Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 2 (LYPLA2) Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:24624468
  • Adibekian, A., Martin, B. R., Chang, J. W., Hsu, K. L., Tsuboi, K., Bachovchin, D. A., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Cravatt, B. F., et al. Characterization of a selective, reversible inhibitor of lysophospholipase 1 (LYPLA1) Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:24624465
  • Nagano, J. M. G., Hsu, K. L., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Bahnson, B. J., Cravatt, B. F., Hodder, P., Rosen, H. Optimization and characterization of a carbamate inhibitor for plasma platelet-activating factor acetylhydrolase (pPAFAH) Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:23658952
  • Dreyton, C. J., Jones, J. E., Knuckley, B. A., Subramanian, V., Anderson, E. D., Brown, S. J., Fernandez-Vega, V., Eberhart, C., Spicer, T., Zuhl, A. M., Ferguson, J., Speers, A. E., et al. Optimization and characterization of a pan protein arginine deiminase (PAD) inhibitor Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:23833800
  • Adibekian, A., Martin, B. R., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Cravatt, B. F., Hodder, P., Rosen, H. Optimization and characterization of a triazole urea dual inhibitor for lysophospholipase 1 (LYPLA1) and lysophospholipase 2 (LYPLA2) Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:23658947
  • Adibekian, A., Hsu, K. L., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Cravatt, B. F., Hodder, P., Rosen, H. Optimization and characterization of a triazole urea inhibitor for alpha/beta hydrolase domain-containing protein 11 (ABHD11): anti-probe for LYPLA1/LYPLA2 dual inhibitor ML211 Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:23658953
  • Hsu, K. L., Tsuboi, K., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Cravatt, B. F., Hodder, P., Rosen, H. Optimization and characterization of a triazole urea inhibitor for diacylglycerol lipase beta (DAGL-beta) Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:23658950
  • Adibekian, A., Hsu, K. L., Speers, A. E., Monillas, E. S., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Bahnson, B. J., Cravatt, B. F., Hodder, P., Rosen, H. Optimization and characterization of a triazole urea inhibitor for platelet-activating factor acetylhydrolase type 2 (PAFAH2) Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:23658960
  • Tsuboi, K., Bachovchin, D. A., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Cravatt, B. F., Hodder, P., Rosen, H. Optimization and characterization of an inhibitor for glutathione S-tranferase omega 1 (GSTO1) Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:22834034
  • Hsu, K. L., Tsuboi, K., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Cravatt, B. F., Hodder, P., Rosen, H. Optimization and characterization of triazole urea inhibitors for abhydrolase domain containing protein 6 (ABHD6) Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:23762934
  • Bachovchin, D. A., Speers, A. E., Brown, S. J., Spicer, T. P., Fernandez, Vega, Ferguson, J., Mohr, J. T., Murphy, J., Fu, G. C., Cravatt, B. F., Hodder, P. S., Rosen, H. Probe development efforts to identify novel inhibitors of protein phosphatase methylesterase-1 (PME-1) Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:22834039
  • Bachovchin, D. A., Speers, A. E., Zuhl, A. M., Brown, S. J., Cravatt, B. F., Fernandez, Vega, Spicer, T., Mercer, B. A., Ferguson, J., Hodder, P., Rosen, H. R. Probe report for PME-1 inhibitors Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:21433379
  • Bachovchin, D. A., Speers, A. E., Brown, S. J., Cravatt, B. F., Spicer, T., Mercer, B. A., Ferguson, J., Hodder, P., Rosen, H. R. Probe report for RBBP9 inhibitors - Probe 2 Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:21433382

Background

education and training

• Ph.D. in Chemistry, Scripps Research 2000 - 2005
• B.A. in Chemistry, Amherst College 1996 - 2000

advisee of

• graduate advising relationship

  • Cravatt, Benjamin, Ph.D.  candidacy, 2001 - 2005

Contact

full name

• Anna Elizabeth Speers

geographic location

• Scripps California