recent publications
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academic article
- Cao, L. W., Pauthner, M., Andrabi, R., Rantalainen, K., Berndsen, Z., Diedrich, J. K., Menis, S., Sok, D., Bastidas, R., Park, S. K. R., Delahunty, C. M., He, L., et al. Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer Nature Communications 2018 9 DOI:10.1038/s41467-018-06121-4 PMID:30209313 PMCID:PMC6135743
- He, L., Kumar, S., Allen, J. D., Huang, D. L., Lin, X., Mann, C. J., Saye-Francisco, K. L., Copps, J., Sarkar, A., Blizard, G. S., Ozorowski, G., Sok, D., et al. HIV-1 vaccine design through minimizing envelope metastability Science Advances 2018 4 DOI:10.1126/sciadv.aau6769 PMID:30474059 PMCID:PMC6248932
- Sok, D., Burton, D. R. Recent progress in broadly neutralizing antibodies to HIV Nature Immunology 2018 19:1179-1188 DOI:10.1038/s41590-018-0235-7 PMID:30333615
- Khan, S. N., Sok, D., Tran, K., Movsesyan, A., Dubrovskaya, V., Burton, D. R., Wyatt, R. T. Targeting the HIV-1 spike and coreceptor with bi- and trispecific antibodies for single-component broad inhibition of entry Journal of Virology 2018 92:e00384-18 DOI:10.1128/jvi.00384-18 PMID:29976677
- Lee, J. H., Andrabi, R., Su, C. Y., Yasmeen, A., Julien, J. P., Kong, L., Wu, N. C., McBride, R., Sok, D., Pauthner, M., Cottrell, C. A., Nieusma, T., et al. A broadly neutralizing antibody targets the dynamic HIV envelope trimer apex via a long, rigidified, and anionic β-hairpin structure Immunity 2017 46:690-702 DOI:10.1016/j.immuni.2017.03.017 PMID:28423342 PMCID:PMC5400778
- Julg, B., Tartaglia, L. J., Keele, B. F., Wagh, K., Pegu, A., Sok, D., Abbink, P., Schmidt, S. D., Wang, K., Chen, X., Joyce, M. G., Georgiev, I. S., et al. Broadly neutralizing antibodies targeting the HIV-1 envelope V2 apex confer protection against a clade C SHIV challenge Science Translational Medicine 2017 9 DOI:10.1126/scitranslmed.aal1321 PMID:28878010
- Freund, N. T., Wang, H., Scharf, L., Nogueira, L., Horwitz, J. A., Bar-On, Y., Golijanin, J., Sievers, S. A., Sok, D., Cai, H., Lorenzi, J. C. C., Halper-Stromberg, A., et al. Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller Science Translational Medicine 2017 9 DOI:10.1126/scitranslmed.aal2144 PMID:28100831
- Morris, C. D., Azadnia, P., de Val, N., Vora, N., Honda, A., Giang, E., Saye-Francisco, K., Cheng, Y. S., Lin, X., Mann, C. J., Tang, J., Sok, D., et al. Differential antibody responses to conserved HIV-1 neutralizing epitopes in the context of multivalent scaffolds and native-like gp140 trimers mBio 2017 8:e00036-17 DOI:10.1128/mBio.00036-17 PMID:28246356 PMCID:PMC5347340
- Voss, J. E., Andrabi, R., McCoy, L. E., de Val, N., Fuller, R. P., Messmer, T., Su, C. Y., Sok, D., Khan, S. N., Garces, F., Pritchard, L. K., Wyatt, R. T., et al. Elicitation of neutralizing antibodies targeting the V2 apex of the HIV Envelope trimer in a wild-type animal model Cell Reports 2017 21:222-235 DOI:10.1016/j.celrep.2017.09.024 PMID:28978475 PMCID:PMC5640805
- Pauthner, M., Havenar-Daughton, C., Sok, D., Nkolola, J. P., Bastidas, R., Boopathy, A. V., Carnathan, D. G., Chandrashekar, A., Cirelli, K. M., Cottrell, C. A., Eroshkin, A. M., Guenaga, J., et al. Elicitation of robust tier 2 neutralizing antibody responses in nonhuman primates by HIV envelope trimer immunization using optimized approaches Immunity 2017 46:1073-1088 DOI:10.1016/j.immuni.2017.05.007 PMID:28636956 PMCID:PMC5483234
- Cao, L., Diedrich, J. K., Kulp, D. W., Pauthner, M., He, L., Park, S. K. R., Sok, D., Su, C. Y., Delahunty, C. M., Menis, S., Andrabi, R., Guenaga, J., et al. Global site-specific N-glycosylation analysis of HIV envelope glycoprotein Nature Communications 2017 8 DOI:10.1038/ncomms14954 PMID:28348411
- He, L., Lin, X., de Val, N., Saye-Francisco, K. L., Mann, C. J., Augst, R., Morris, C. D., Azadnia, P., Zhou, B., Sok, D., Ozorowski, G., Ward, A. B., et al. Hidden lineage complexity of glycan-dependent HIV-1 broadly neutralizing antibodies uncovered by digital panning and native-like gp140 trimer Frontiers in Immunology 2017 8 DOI:10.3389/fimmu.2017.01025
- Xie, J., Sok, D., Wu, N. C., Zheng, T., Zhang, W., Burton, D. R., Lerner, R. A. Immunochemical engineering of cell surfaces to generate virus resistance Proceedings of the National Academy of Sciences of the United States of America 2017 114:4655-4660 DOI:10.1073/pnas.1702764114 PMID:28396429 PMCID:PMC5422804
- Irimia, A., Serra, A. M., Sarkar, A., Jacak, R., Kalyuzhniy, O., Sok, D., Saye-Francisco, K. L., Schiffner, T., Tingle, R., Kubitz, M., Adachi, Y., Stanfield, R. L., et al. Lipid interactions and angle of approach to the HIV-1 viral membrane of broadly neutralizing antibody 10E8: Insights for vaccine and therapeutic design PLoS Pathogens 2017 13 DOI:10.1371/journal.ppat.1006212 PMID:28225819 PMCID:PMC5338832
- Magnani, D. M., Rogers, T. F., Beutler, N., Ricciardi, M. J., Bailey, V. K., Gonzalez-Nieto, L., Briney, B., Sok, D., Le, K., Strubel, A., Gutman, M. J., Pedreno-Lopez, N., et al. Neutralizing human monoclonal antibodies prevent Zika virus infection in macaques Science Translational Medicine 2017 9 DOI:10.1126/scitranslmed.aan8184 PMID:28978754
- Julg, B., Sok, D., Schmidt, S. D., Abbink, P., Newman, R. M., Broge, T., Linde, C., Nkolola, J., Le, K., Su, D., Torabi, J., Pack, M., et al. Protective efficacy of broadly neutralizing antibodies with incomplete neutralization activity against simian-human immunodeficiency virus in rhesus monkeys Journal of Virology 2017 91:e01187-17 DOI:10.1128/jvi.01187-17 PMID:28768869 PMCID:PMC5625479
- Sok, D., Le, K. M., Vadnais, M. L., Saye-Francisco, K. L., Jardine, J. G., Torres, J. L., Berndsen, Z. T., Kong, L., Tanfield, R. S., Ruiz, J., Ramos, A., Liang, C. H., et al. Rapid elicitation of broadly neutralizing antibodies to HIV by immunization in cows Nature 2017 548:108-111 DOI:10.1038/nature23301 PMID:28726771
- Rogers, T. F., Goodwin, E. C., Briney, B., Sok, D., Beutler, N., Strubel, A., Nedellec, R., Le, K., Brown, M. E., Burton, D. R., Walker, L. M. Zika virus activates de novo and cross-reactive memory B cell responses in dengue-experienced donors Science Immunology 2017 2 DOI:10.1126/sciimmunol.aan6809 PMID:28821561 PMCID:PMC5892203
- Sok, D., Pauthner, M., Briney, B., Lee, J. H., Saye-Francisco, K. L., Hsueh, J., Ramos, A., Le, K. M., Jones, M., Jardine, J. G., Bastidas, R., Sarkar, A., et al. A prominent site of antibody vulnerability on HIV envelope incorporates a motif associated with CCR5 binding and its camouflaging glycans Immunity 2016 45:31-45 DOI:10.1016/j.immuni.2016.06.026 PMID:27438765 PMCID:PMC4990068
- van Gils, M. J., van den Kerkhof, T. L., Ozorowski, G., Cottrell, C. A., Sok, D., Pauthner, M., Pallesen, J., de Val, N., Yasmeen, A., de Taeye, S. W., Schorcht, A., Gumbs, S., et al. An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability Nature Microbiology 2016 2 DOI:10.1038/nmicrobiol.2016.199 PMID:27841852 PMCID:PMC5372380
- Liu, J., Ghneim, K., Sok, D., Bosche, W. J., Li, Y., Chipriano, E., Berkemeier, B., Oswald, K., Borducchi, E., Cabral, C., Peter, L., Brinkman, A., et al. Antibody-mediated protection against SHIV challenge includes systemic clearance of distal virus Science 2016 353:1045-1049 DOI:10.1126/science.aag0491 PMID:27540005
- Havenar-Daughton, C., Carnathan, D. G., Torrents de la Peña, A., Pauthner, M., Briney, B., Reiss, S. M., Wood, J. S., Kaushik, K., van Gils, M. J., Rosales, S. L., van der Woude, P., Locci, M., et al. Direct probing of germinal center responses reveals immunological features and bottlenecks for neutralizing antibody responses to HIV Env trimer Cell Reports 2016 17:2195-2209 DOI:10.1016/j.celrep.2016.10.085 PMID:27880897 PMCID:PMC5142765
- Sok, D., Burton, D. R. HIV broadly neutralizing antibodies: taking good care of the 98% Immunity 2016 45:958-960 DOI:10.1016/j.immuni.2016.10.033 PMID:27851923
- Jardine, J. G., Kulp, D. W., Havenar-Daughton, C., Sarkar, A., Briney, B., Sok, D., Sesterhenn, F., Ereno-Orbea, J., Kalyuzhniy, O., Deresa, I., Hu, X., Spencer, S., et al. HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogene Science 2016 351:1458-1463 DOI:10.1126/science.aad9195 PMID:27013733 PMCID:PMC4872700
- McCoy, L. E., van Gils, M. J., Ozorowski, G., Messmer, T., Briney, B., Voss, J. E., Kulp, D. W., Macauley, M. S., Sok, D., Pauthner, M., Menis, S., Cottrell, C. A., et al. Holes in the glycan shield of the native HIV Envelope are a target of trimer-elicited neutralizing antibodies Cell Reports 2016 16:2327-2338 DOI:10.1016/j.celrep.2016.07.074 PMID:27545891 PMCID:PMC5007210
- Bornholdt, Z. A., Turner, H. L., Murin, C. D., Li, W., Sok, D., Souders, C. A., Piper, A. E., Goff, A., Shamblin, J. D., Wollen, S. E., Sprague, T. R., Fusco, M. L., et al. Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak Science 2016 351:1078-1083 DOI:10.1126/science.aad5788 PMID:26912366 PMCID:PMC4900763
- Jardine, J. G., Sok, D., Julien, J. P., Briney, B., Sarkar, A., Liang, C. H., Scherer, E. A., Henry Dunand, C. J., Adachi, Y., Diwanji, D., Hsueh, J., Jones, M., et al. Minimally mutated HIV-1 broadly neutralizing antibodies to guide reductionist vaccine design PLoS Pathogens 2016 12 DOI:10.1371/journal.ppat.1005815 PMID:27560183 PMCID:PMC4999182
- He, L., de Val, N., Morris, C. D., Vora, N., Thinnes, T. C., Kong, L., Azadnia, P., Sok, D., Zhou, B., Burton, D. R., Wilson, I. A., Nemazee, D., et al. Presenting native-like trimeric HIV-1 antigens with self-assembling nanoparticles Nature Communications 2016 7 DOI:10.1038/ncomms12041 PMID:27349934 PMCID:PMC4931238
- Sok, D., Briney, B., Jardine, J. G., Kulp, D. W., Menis, S., Pauthner, M., Wood, A., Lee, E. C., Le, K. M., Jones, M., Ramos, A., Kalyuzhniy, O., et al. Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic mice Science 2016 353:1557-1560 DOI:10.1126/science.aah3945 PMID:27608668 PMCID:PMC5404394
- Escolano, A., Steichen, J. M., Dosenovic, P., Kulp, D. W., Golijanin, J., Sok, D., Freund, N. T., Gitlin, A. D., Oliveira, T., Araki, T., Lowe, S., Chen, S. T., et al. Sequential immunization elicits broadly neutralizing anti-HIV-1 antibodies in Ig knockin mice Cell 2016 166:1445-1458 DOI:10.1016/j.cell.2016.07.030 PMID:27610569 PMCID:PMC5019122
- Briney, B., Sok, D., Jardine, J. G., Kulp, D. W., Skog, P., Menis, S., Jacak, R., Kalyuzhniy, O., de Val, N., Sesterhenn, F., Le, K. M., Ramos, A., et al. Tailored immunogens direct affinity maturation toward HIV neutralizing antibodies Cell 2016 166:1459-1470 DOI:10.1016/j.cell.2016.08.005 PMID:27610570 PMCID:PMC5018249
- Kong, L., He, L., de Val, N., Vora, N., Morris, C. D., Azadnia, P., Sok, D., Zhou, B., Burton, D. R., Ward, A. B., Wilson, I. A., Zhu, J. Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability Nature Communications 2016 7 DOI:10.1038/ncomms12040 PMID:27349805 PMCID:PMC4931249
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Sanders, R. W., van Gils, M. J., Derking, R., Sok, D., Ketas, T. J., Burger, J. A., Ozorowski, G., Cupo, A., Simonich, C., Goo, L., Arendt, H., Kim, H. J., et al.
HIV-1 neutralizing antibodies induced by native-like envelope trimers
Science
2015
349:aac4223
DOI:10.1126/science.aac4223
PMID:26089353
PMCID:PMC4498988
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McCoy, L. E., Falkowska, E., Doores, K. J., Le, K., Sok, D., van Gils, M. J., Euler, Z., Burger, J. A., Seaman, M. S., Sanders, R. W., Schuitemaker, H., Poignard, P., et al.
Incomplete neutralization and deviation from sigmoidal neutralization curves for HIV broadly neutralizing monoclonal antibodies
PLoS Pathogens
2015
11:e1005110
DOI:10.1371/journal.ppat.1005110
PMID:26267277
PMCID:PMC4534392
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Asmal, M., Luedemann, C., Lavine, C. L., Mach, L. V., Balachandran, H., Brinkley, C., Denny, T. N., Lewis, M. G., Anderson, H., Pal, R., Sok, D., Le, K., et al.
Infection of monkeys by simian-human immunodeficiency viruses with transmitted/founder clade C HIV-1 envelopes
Virology
2015
475:37-45
DOI:10.1016/j.virol.2014.10.032
PMID:25462344
PMCID:PMC4280322
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Hu, J. K., Crampton, J. C., Cupo, A., Ketas, T., van Gils, M. J., Sliepen, K., de Taeye, S. W., Sok, D., Ozorowski, G., Deresa, I., Stanfield, R., Ward, A. B., et al.
Murine antibody responses to cleaved soluble HIV-1 envelope trimers are highly restricted in specificity
Journal of Virology
2015
89:10383-10398
DOI:10.1128/jvi.01653-15
PMID:26246566
PMCID:PMC4580201
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Jardine, J. G., Ota, T., Sok, D., Pauthner, M., Kulp, D. W., Kalyuzhniy, O., Skog, P. D., Thinnes, T. C., Bhullar, D., Briney, B., Menis, S., Jones, M., et al.
Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen
Science
2015
349:156-161
DOI:10.1126/science.aac5894
PMID:26089355
PMCID:PMC4669217
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Doores, K. J., Kong, L., Krumm, S. A., Le, K. M., Sok, D., Laserson, U., Garces, F., Poignard, P., Wilson, I. A., Burton, D. R.
Two classes of broadly neutralizing antibodies within a single lineage directed to the high-mannose patch of HIV envelope
Journal of Virology
2015
89:1105-1118
DOI:10.1128/jvi02905-14
PMID:25378488
PMCID:PMC4300629
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Almagro, J. C., Gilliland, G. L., Breden, F., Scott, J. K., Sok, D., Pauthner, M., Reichert, J. M., Helguera, G., Andrabi, R., Mabry, R., Blery, M., Voss, J. E., et al.
Antibody engineering and therapeutics, The Annual Meeting of the Antibody Society: December 8-12, 2013, Huntington Beach, CA
MAbs
2014
6:577-618
DOI:10.4161/mabs.28421
PMID:24589717
PMCID:PMC4011904
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Sok, D., Doores, K. J., Briney, B., Le, K. M., Saye-Francisco, K. L., Ramos, A., Kulp, D. W., Julien, J. P., Menis, S., Wickramasinghe, L., Seaman, M. S., Schief, W. R., et al.
Promiscuous glycan site recognition by antibodies to the high-mannose patch of gp120 broadens neutralization of HIV
Science Translational Medicine
2014
6:236ra63
DOI:10.1126/scitranslmed.3008104
PMID:24828077
PMCID:PMC4095976
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Sok, D., van Gils, M. J., Pauthner, M., Julien, J. P., Saye-Francisco, K. L., Hsueh, J., Briney, B., Lee, J. H., Le, K. M., Lee, P. S., Hua, Y., Seaman, M. S., et al.
Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex
Proceedings of the National Academy of Sciences of the United States of America
2014
111:17624-17629
DOI:10.1073/pnas.1415789111
PMID:25422458
PMCID:PMC4267403
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Garces, F., Sok, D., Kong, L., McBride, R., Kim, H. J., Saye-Francisco, K. F., Julien, J. P., Hua, Y., Cupo, A., Moore, J. P., Paulson, J. C., Ward, A. B., et al.
Structural evolution of glycan recognition by a family of potent HIV antibodies
Cell
2014
159:69-79
DOI:10.1016/j.cell.2014.09.009
PMID:25259921
PMCID:PMC4278586
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Murin, C. D., Julien, J. P., Sok, D., Stanfield, R. L., Khayat, R., Cupo, A., Moore, J. P., Burton, D. R., Wilson, I. A., Ward, A. B.
Structure of 2G12 Fab2 in complex with soluble and fully glycosylated HIV-1 Env by negative-stain single-particle electron microscopy
Journal of Virology
2014
88:10177-10188
DOI:10.1128/jvi.01229-14
PMID:24965454
PMCID:PMC4136306
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He, L., Sok, D., Azadnia, P., Hsueh, J., Landais, E., Simek, M., Koff, W. C., Poignard, P., Burton, D. R., Zhu, J.
Toward a more accurate view of human B-cell repertoire by next-generation sequencing, unbiased repertoire capture and single-molecule barcoding
Scientific Reports
2014
4:6778
DOI:10.1038/srep06778
PMID:25345460
PMCID:PMC4894419
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Julien, J. P., Sok, D., Khayat, R., Lee, J. H., Doores, K. J., Walker, L. M., Ramos, A., Diwanji, D. C., Pejchal, R., Cupo, A., Katpally, U., Depetris, R. S., et al.
Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans
PLoS Pathogens
2013
9:e1003342
DOI:10.1371/journal.ppat.1003342
PMID:23658524
PMCID:PMC3642082
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Julien, J. P., Cupo, A., Sok, D., Stanfield, R. L., Lyumkis, D., Deller, M. C., Klasse, P. J., Burton, D. R., Sanders, R. W., Moore, J. P., Ward, A. B., Wilson, I. A.
Crystal structure of a soluble cleaved HIV-1 envelope trimer
Science
2013
342:1477-1483
DOI:10.1126/science.1245625
PMID:24179159
PMCID:PMC3886632
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Jardine, J., Julien, J. P., Menis, S., Ota, T., Kalyuzhniy, O., McGuire, A., Sok, D., Huang, P. S., MacPherson, S., Jones, M., Nieusma, T., Mathison, J., et al.
Rational HIV immunogen design to target specific germline B cell receptors
Science
2013
340:711-716
DOI:10.1126/science.1234150
PMID:23539181
PMCID:PMC3689846
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Sok, D., Burton, D. R.
SnapShot: broadly neutralizing antibodies
Cell
2013
155:728
DOI:10.1016/j.cell.2013.10.009
PMID:24243025
PMCID:PMC4070420
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Sok, D., Laserson, U., Laserson, J., Liu, Y., Vigneault, F., Julien, J. P., Briney, B., Ramos, A., Saye, K. F., Le, K., Mahan, A., Wang, S., et al.
The effects of somatic hypermutation on neutralization and binding in the PGT121 family of broadly neutralizing HIV antibodies
PLoS Pathogens
2013
9:e1003754
DOI:10.1371/journal.ppat.1003754
PMID:24278016
PMCID:PMC3836729
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Ota, T., Doyle-Cooper, C., Cooper, A. B., Huber, M., Falkowska, E., Doores, K. J., Hangartner, L., Le, K., Sok, D., Jardine, J., Lifson, J., Wu, X. L., et al.
Anti-HIV B Cell lines as candidate vaccine biosensors
Journal of Immunology
2012
189:4816-4824
DOI:10.4049/jimmunol.1202165
PMID:23066156
PMCID:PMC3626558
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Marrinucci, D., Bethel, K., Kolatkar, A., Luttgen, M. S., Malchiodi, M., Baehring, F., Voigt, K., Lazar, D., Nieva, J., Bazhenova, L., Ko, A. H., Korn, W. M., et al.
Fluid biopsy in patients with metastatic prostate, pancreatic and breast cancers
Physical Biology
2012
9:016003
DOI:10.1088/1478-3975/9/1/016003
PMID:22306768
PMCID:PMC3387996
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Kazane, S. A., Sok, D., Cho, E. H., Uson, M. L., Kuhn, P., Schultz, P. G., Smider, V. V.
Site-specific DNA-antibody conjugates for specific and sensitive immuno-PCR
Proceedings of the National Academy of Sciences of the United States of America
2012
109:3731-3736
DOI:10.1073/pnas.1120682109
PMID:22345566
PMCID:PMC3309776
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Walker, L. M., Sok, D., Nishimura, Y., Donau, O., Sadjadpour, R., Gautam, R., Shingai, M., Pejchal, R., Ramos, A., Simek, M. D., Geng, Y., Wilson, I. A., et al.
Rapid development of glycan-specific, broad, and potent anti-HIV-1 gp120 neutralizing antibodies in an R5 SIV/HIV chimeric virus infected macaque
Proceedings of the National Academy of Sciences of the United States of America
2011
108:20125-20129
DOI:10.1073/pnas.1117531108
PMID:22123961
PMCID:PMC3250170